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Health and Community Sciences

Exeter Test Group

Exeter South Cloisters

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About us

Tests have an increasingly important role in health. The Exeter Test Group is an internationally recognised centre of excellence for test evaluation. Led by Professor Chris Hyde, we have expertise in using research on tests to inform policy and methods of improving the understanding of research on tests. We have particular skills in systematic review, meta-analysis, economic modelling and health technology assessment.

Medical tests have an ever greater impact on health care. They can be anything which provides information which helps diagnose disease, screens for early disease, monitors response to treatment or provides an indication of the outlook for a patient (their prognosis). Good tests are essential for successful stratified medicine approaches, and are critical to delivering the promises of precision medicine. Tests can take a wide variety of forms, but the most common are blood tests, X-rays, scans or questionnaires.

Based in the Faculty of Health and Life Sciences and the University of Exeter Medical School, The Exeter Test Group is an established centre of excellence in test evaluation working collaboratively with many other groups particularly PenTAG, ESMI, PenARC, Health Economics, Health Statistics, Cancer diagnosis (DISCO) and Molecular Genetics. We are a diverse and multi-skilled group of researchers united by our interest in solving the challenges of how to identify which tests make the greatest contribution to health, and which represent the best value for money as many tests are increasingly expensive and consume valuable time to conduct and incorporate into practice.

With backgrounds in psychological assessment, public health, clinical epidemiology, systematic review, realist evaluation, health care modelling and the use of expert elicitation for decision-analytic models, we draw on a wide range of expertise and experience in order to evaluate medical tests for real world applications. As well as evaluation, we have interests in helping improve the interpretation of research on tests by doctors, nurses, professions allied to medicine and patients themselves.

We are closely involved in national policy making on new tests, working closely with the National Screening Committee and NICE. We are headed by Professor Chris Hyde, an expert in health technology assessment of tests.

The aims of this theme are to improve the health of people in the South West and beyond by:

  • producing generalisable research evidence about diagnostic strategies
  • developing and spreading evidence-based diagnostic pathways in the South West Peninsula, and
  • increasing the South West Peninsula’s capacity to deliver world-class research in diagnostics.

These aims recognise that knowledge about individual tests is maximised only when it is translated into evidence about diagnostic strategies that are, in turn, integrated with evidence about patient management in diagnostic pathways. Linkage of evidence is thus important.

Name Position
Chris Hyde Professor of Public Health and Clinical Epidemiology
Jaime Peters Senior Research Fellow
Zhivko Zhelev Research Fellow
Bogdan Grigore Associate Research Fellow

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Key publications


Ferrante di Ruffano L, Harris IM, Zhelev Z, Davenport C, Mallett S, Peters J, Takwoingi Y, Deeks J, Hyde C (2023). Health technology assessment of diagnostic tests: a state of the art review of methods guidance from international organizations. Int J Technol Assess Health Care, 39(1).

Zhelev Z, Peters J, Rogers M, Allen M, Kijauskaite G, Seedat F, Wilkinson E, Hyde C (2023). Test accuracy of artificial intelligence-based grading of fundus images in diabetic retinopathy screening: a systematic review. J Med Screen


Thompson G, Zhelev Z, Hunt H, Hyde C (2022). It was not easy to identify the study design from the title and abstract of articles indexed as diagnostic (test) accuracy studies in EMBASE in 2012 and 2019. J Clin Epidemiol, 144, 102-110.

Ohtake H, Terasawa T, Zhelev Z, Iwata M, Rogers M, Peters JL, Hyde C (2022). Serial high-sensitivity cardiac troponin testing for the diagnosis of myocardial infarction: a scoping review. BMJ Open, 12(11), e066429-e066429.

Taylor-Phillips S, Seedat F, Kijauskaite G, Marshall J, Halligan S, Hyde C, Given-Wilson R, Wilkinson L, Denniston AK, Glocker B, et al (2022). UK National Screening Committee's approach to reviewing evidence on artificial intelligence in breast cancer screening. Lancet Digit Health, 4(7), e558-e565.

Ball S, Hyde C, Hamilton W, Bright CJ, Gildea C, Wong KF, . . . Elliss-Brookes L. (2022) An evaluation of a national mass media campaign to raise public awareness of possible lung cancer symptoms in England in 2016 and 2017. Br J Cancer, 126(2):187-195. doi:10.1038/s41416-021-01573-w

Merriel SWD, Ball S, Bright CJ, Mak V, Gildea C, Paley L, Hyde C, Hamilton W, Elliss-Brookes L. (2022) A prospective evaluation of the fourth national Be Clear on Cancer 'Blood in Pee' campaign in England. Eur J Cancer Care (Engl), 31(5): e13606. doi:10.1111/ecc.13606

Peters JL, Snowsill TM, Griffin E, Robinson S, Hyde CJ. (2022) Variation in Model-Based Economic Evaluations of Low-Dose Computed Tomography Screening for Lung Cancer: A Methodological Review. Value Health, 25(4):656-665. doi:10.1016/j.jval.2021.11.1352


Hajibandeh S, Hajibandeh S, Marshall MJ, Smart NJ, Winyard PG, Hyde C, Shaw AM, Daniels IR (2021). Biomarkers for diagnosis of acute appendicitis in adults. Cochrane Database of Systematic Reviews, 2021(10).

Binney N, Hyde C, Bossuyt PM (2021). On the Origin of Sensitivity and Specificity. Annals of Internal Medicine, 174(3), 401-407.

Kokkinou M, Beishon LC, Smailagic N, Noel-Storr AH, Hyde C, Ukoumunne O, Worrall RE, Hayen A, Desai M, Ashok AH, et al (2021). Plasma and cerebrospinal fluid ABeta42 for the differential diagnosis of Alzheimer's disease dementia in participants diagnosed with any dementia subtype in a specialist care setting. Cochrane Database Syst Rev, 2(2).

Cohen JF, Deeks JJ, Hooft L, Salameh J-P, Korevaar DA, Gatsonis C, Hopewell S, Hunt HA, Hyde CJ, Leeflang MM, et al (2021). Preferred reporting items for journal and conference abstracts of systematic reviews and meta-analyses of diagnostic test accuracy studies (PRISMA-DTA for Abstracts): checklist, explanation, and elaboration. BMJ, 372. 

Yang B, Mallett S, Takwoingi Y, Davenport CF, Hyde CJ, Whiting PF, Deeks JJ, Leeflang MMG (2021). QUADAS-C: a Tool for Assessing Risk of Bias in Comparative Diagnostic Accuracy Studies. Annals of Internal Medicine, 174(11), 1592-1599.

Yang B, Olsen M, Vali Y, Langendam MW, Takwoingi Y, Hyde CJ, Bossuyt PMM, Leeflang MMG (2021). Study designs for comparative diagnostic test accuracy: a methodological review and classification scheme. J Clin Epidemiol, 138, 128-138.

G Thompson, Z Zhelev, J Peters, S Khalid, S Briscoe, L Shaw, M Nunns, S Ludman, C Hyde. Symptom scores in the diagnosis of pediatric cow’s milk protein allergy: A systematic review. Pediatric Allergy and Immunology: 32(7):1497-1507.


Bossuyt PM, Olsen M, Hyde C, Cohen JF (2020). An analysis reveals differences between pragmatic and explanatory diagnostic accuracy studies. J Clin Epidemiol, 117, 29-35.

B Grigore, R Lewis, J Peters, S Robinson, C Hyde. Development, validation and effectiveness of diagnostic prediction tools for colorectal cancer in primary care: a systematic review. BMC Cancer 20:1084

A Medina-Lara, B Grigore, R Lewis, J Peters, S Price, P Lando, S Robinson, R Neal, W Hamilton, A Spencer. Understanding the effectiveness, cost-effectiveness and current use of cancer diagnostic tools to aid decision-making in primary care. HTA Journal 24(66)

S Mallett, AJ Allen, S Garaziado, SA Taylor, NS Sakai, K Green, J Suklan, C Hyde, B Shinkins, Z Zhelev, J Peters, PJ Turner, NW Roberts, L Ferrante di Ruffano, R Wolff, P Whiting, A Winter, G Bhatnagar, BD Nicholson, S Halligan. At what times during infection is SARS-CoV-2 detectable and no longer detectable using RT-PCR-based tests? A systematic review of individual participant data. BMC Medicine 18:346

JL Peters, R Anderson, B Shields, S King, M Hudson, M Shepherd, T McDonald, E Pearson, A Hattersley, C Hyde. Strategies to identify individuals with monogenic diabetes: results of a health economic model. BMJ Open 10:3

Uttley L, Indave BI, Hyde C, White V, Lokuhetty D, Cree I (2020). Invited commentary-WHO Classification of Tumours: How should tumors be classified? Expert consensus, systematic reviews or both?. Int J Cancer, 146(12), 3516-3521.

Griffin E, Hyde C, Long L, Varley-Campbell J, Coelho H, Robinson S, Snowsill T (2020). Lung cancer screening by low-dose computed tomography: a cost-effectiveness analysis of alternative programmes in the UK using a newly developed natural history-based economic model. Diagnostic and Prognostic Research, 4(1).

Takwoingi Y, Partlett C, Riley RD, Hyde C, Deeks JJ (2020). Methods and reporting of systematic reviews of comparative accuracy were deficient: a methodological survey and proposed guidance. J Clin Epidemiol, 121, 1-14.

Salameh JP, Bossuyt PM, McGrath TA, Thombs BD, Hyde CJ, MacAskill P, Deeks JJ, Leeflang M, Korevaar DA, Whiting P, et al (2020). Preferred reporting items for systematic review and meta-analysis of diagnostic test accuracy studies (PRISMA-DTA): Explanation, elaboration, and checklist. The BMJ, 370(12).

Shaw AM, Hyde C, Merrick B, James-Pemberton P, Squires BK, Olkhov RV, Batra R, Patel A, Bisnauthsing K, Nebbia G, et al (2020). Real-world evaluation of a novel technology for quantitative simultaneous antibody detection against multiple SARS-CoV-2 antigens in a cohort of patients presenting with COVID-19 syndrome. Analyst, 145(16), 5638-5646.

McGovern AP, Hogg M, Shields BM, Sattar NA, Holman RR, Pearson ER, Hattersley AT, Jones AG, Dennis JM (2020). Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation. BMJ Open Diabetes Research & Care, 8(1), e001238-e001238.

Yang B, Vali Y, Dehmoobad Sharifabadi A, Harris IM, Beese S, Davenport C, Hyde C, Takwoingi Y, Whiting P, Langendam MW, et al (2020). Risk of bias assessment of test comparisons was uncommon in comparative accuracy systematic reviews: an overview of reviews. J Clin Epidemiol, 127, 167-174.


H Yang, J Varley-Campbell, H Coelho, L Long, S Robinson, T Snowsill, E Griffin, J Peters, C Hyde. Do we know enough about the effect of low dose computed tomography screening for lung cancer on survival to act? A systematic review, meta-analysis and network meta-analysis of randomised controlled trials. Diagnostic and Prognostic Research 3(23).

Hunt H (2019). Improving the accuracy of brief cognitive assessments when used as part of the process for identifying dementia in general practice. PhD thesis Full text.

McCartney M, Fell G, Finnikin S, Hunt H, McHugh M, Gray M. Why 'case finding' is bad science. Journal of the Royal Society of Medicine 113(2):54-58.

McGovern AP, Dennis JM, Shields BM, Hattersley AT, Pearson ER, Jones AG, Henley WE, Lonergan M, Rodgers LR, Hamilton WT, Sattar NA, Holman RR, Angwin C, Cruickshank KJ, Farmer AJ, Gough SCL, Gray AM, Hyde C, Jennison C, Walker M. What to do with diabetes therapies when HbA1c lowering is inadequate: Add, switch, or continue? A MASTERMIND study. BMC Medicine 17(1):79.

Olsen M, Zhelev Z, Hunt H, Peters J, Bossuyt PM, Hyde C (2019) Use of Test Accuracy Study Design Labels in NICE’s Diagnostic Guidance. Diagnostic and Prognostic Research 3:17

Peultier AC, Redekop K, Allen M, Peters J, Omer E, and J Severens (2019) Exploring the cost-effectiveness of mechanical thrombectomy beyond six-hours following advanced imaging in the UK. Stroke 50(11):3220-3227

Reader P, Shaw A, Hyde C, Olkhov R.  A rapid and quantitative technique for assessing IgG monomeric purity, calibrated with the NISTmAb reference material. Analytical and Bioanalytical Chemistry 2019;411:6487–6496.

Varley-Campbell J, Mújica-Mota R, Coelho H, Ocean N, Barnish M, Packman D, Dodman S, Cooper C, Snowsill T, Kay T, Liversedge N, Parr M, Knight L, Hyde C, Shennan A, Hoyle M. Three biomarker tests to help diagnose preterm labour: a systematic review and economic evaluation. Health Technology Assessment 2019;23(13):1-226.

Wolff RF, Moons KGM, Riley RD, Whiting PF, Westwood M, Collins GS, Reitsma JB, Kleijnen J, Mallett S, for the PROBAST group (of which C Hyde was a part).  PROBAST: A Tool to Assess the Risk of Bias and Applicability of Prediction Model Studies.  Ann Intern Med 2019;170(1):51-58.

Z Zhelev, H Ohtake, M Iwata, T Terasawa, M Rogers, J Peters, C Hyde, Diagnostic accuracy of contemporary and high-sensitivity cardiac troponin assays used in serial testing, versus single-sample testing as a comparator, to triage patients suspected of acute non-ST-segment elevation myocardial infarction: a systematic review protocol BMJ Open 2019;9:e026012. doi: 10.1136/bmjopen-2018-026012

Zhelev Z, Walker G, Henschke N, Fridhandler J, Yip S. Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack. Cochrane Database Syst Rev. 2019 Apr 9;4:CD011427. doi: 10.1002/14651858.CD011427.pub2.

Walker G, Zhelev Z, Henschke N, Fridhandler J, Yip S. Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack. Stroke. 2019;50:e285–e286


Shepherd MH, Shields BM, Hudson M, Pearson ER, Hyde C, Ellard S, Hattersley AT, Patel KA. A UK nationwide prospective study of treatment change in MODY: genetic subtype and clinical characteristics predict optimal glycaemic control after discontinuing insulin and metformin. Diabetologia 2018;61(12):2520-2527.

Smailagic N, Lafortune L, Kelly S, Hyde C, Brayne C. F-18-FDG PET for Prediction of Conversion to Alzheimer's Disease Dementia in People with Mild Cognitive Impairment: An Updated Systematic Review of Test Accuracy. J Alzheimers Dis 2018;64(4):1175-1194.

Snowsill T, Yang H, Griffin E, Long L, Varley-Campbell J, Coelho H, Robinson S, Hyde C.  Low-dose computed tomography for lung cancer screening in high-risk populations: A systematic review and economic evaluation. Health Technology Assessment 2018;22(69):1-276.

CONFERENCE ABSTRACT: Thompson AJ, Page O, Runswick E, Hyde C, Payne K. First do no harm. Exploring the interpretation of NICE diagnostic assessments with cost savings and QALY loss. Value in Health 2018;21:S264-S265.

CONFERENCE ABSTRACT: Varley-Campbell J, Dodman S, Coelho H, Cooper C, Barnish M, Mujica-Mota R, Hyde C, Hoyle M. Full texts vs. conference abstract data, how does the message change? HTAi 2018. 01 Jun 2018      

Walker GJ, Moore L, Heerasing N, Hendy P, Perry MH, McDonald TJ, Debenham T, Bethune R, Bewshea C, Hyde C, Heap GA, Singh A, Calvert C, Kennedy NA, Goodhand JR, Ahmad T. Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study. Aliment Pharmacol Ther 2018;47(8):1103-1116.

Hunt H, Pollock A, Campbell P, Estcourt L and Brunton G, 2018. An introduction to overviews of reviews: planning a relevant research question and objective for an overview. Systematic reviews, 7(1), p.39

C Lap Pang, N Pilkington, Y Wei, J Peters, C Roobottom, C Hyde. A methodology review on the incremental prognostic value of computed tomography biomarkers in addition to Framingham risk score in predicting cardiovascular disease: the use of association, discrimination and reclassification. BMC Cardiovascular Disorders 2018 18:39.

McInnes MDF, Moher D, Thombs BD, McGrath TA, Bossuyt PM; the PRISMA-DTA Group, Clifford T, Cohen JF, Deeks JJ, Gatsonis C, Hooft L, Hunt HA, Hyde CJ, Korevaar DA, Leeflang MMG, Macaskill P, Reitsma JB, Rodin R, Rutjes AWS, Salameh JP, Stevens A, Takwoingi Y, Tonelli M, Weeks L, Whiting P, Willis BH. Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies: The PRISMA-DTA Statement. JAMA. 2018 Jan 23;319(4):388-396. doi: 10.1001/jama.2017.19163. PubMed PMID: 29362800 (extension available here:


Coelho H, Jones-Hughes T, Snowsill T, Briscoe S, Huxley N, Frayling IM, Hyde C. A systematic review of test accuracy studies evaluating molecular micro-satellite instability testing for the detection of individuals with lynch syndrome. BMC Cancer 2017;17:836

Ferrante di Ruffano L, Dinnes J, Sitch AJ, Hyde C, Deeks JJ. Test-treatment RCTs are susceptible to bias: A review of the methodological quality of randomized trials that evaluate diagnostic tests. BMC Medical Research Methodology 2017;17(1):24 Feb. DOI: 10.1186/s12874-016-0287-z

Ferrante Di Ruffano L, Dinnes J, Taylor-Phillips S, Davenport C, Hyde C, Deeks JJ. Research waste in diagnostic trials: A methods review evaluating the reporting of test-treatment interventions. BMC Medical Research Methodology 2017;17(1):24 Feb. DOI: 10.1186/s12874-016-0286-0

Hunt HA, Van Kampen S, Takwoingi Y, Llewellyn DJ, Pearson M, Hyde CJ. The comparative diagnostic accuracy of the Mini Mental State Examination (MMSE) and the General Practitioner assessment of Cognition (GPCOG) for identifying dementia in primary care: a systematic review protocol. Diagnostic and Prognostic Research. 2017 Dec;1(1):14

Perazzo H, Pacheco AG, Luz PM, Castro R, Hyde C, Fittipaldi J, Rigolon C, Cardoso SW, Grinsztejn B, Veloso VG.  Age-standardized mortality rates related to viral hepatitis in Brazil. BMC Infect Dis 2017 Jul 31;17(1):527. Epub 2017 Jul 31.

Perazzo H, Jorge MJ, Silva JC, Avellar AM, Silva PS, Romero C, Veloso VG, Mujica-Mota R, Anderson R, Hyde C et al. Micro-costing analysis of guideline-based treatment by direct-acting agents: The real-life case of hepatitis C management in Brazil. BMC Gastroenterology 2017;17(1):23 Nov 2017

Pollock A, Campbell P, Brunton G, Hunt H, Estcourt L. Selecting and implementing overview methods: implications from five exemplar overviews. Systematic reviews. 2017 Dec;6(1):145.

Shields BM, Shepherd M, Hudson M, McDonald TJ, Colclough K, Peters J, Knight B, Hyde C, Ellard S, Pearson ER, Hattersley AT, UNITED study team. Population-based assessment of a biomarker-based screening pathway to aid diagnosis of monogenic diabetes in young-onset patients. Diabetes Care 40(8):1017-1025

Snowsill T, Coelho H, Huxley N, Jones-Hughes T, Briscoe S, Frayling IM, Hyde C. Molecular testing for Lynch syndrome in people with colorectal cancer: Systematic reviews and economic evaluation. Health Technology Assessment 2017;21(51)

Tenant S, Pang CL, Dissanayake P, Vardhanabhuti V, Stuckey C, Gutteridge C, Hyde C, Roobottom C. Intra-patient comparison of reduced-dose model-based iterative reconstruction with standard-dose adaptive statistical iterative reconstruction in the CT diagnosis and follow-up of urolithiasis. European Radiology 2017;13 Mar:1-10. doi:10.1007/s00330-017-4783-2

Ukoumunne OC, Hyde C, Ozolins M, et al. (including Z. Zhelev) A directly comparative two gate case–control diagnostic accuracy study of the pure tone screen and HearCheck screener tests for identifying hearing impairment in school children. BMJ Open 2017;7:e017258. doi:10.1136/bmjopen-2017-017258

van Giessen, J Peters, B Wilcher, C Hyde, C Moons, A de Wit, E Koffijberg. Systematic review of health economic impact evaluations of risk prediction models: stop developing, start evaluating. Value in Health 20(4):718-726

Vardhanabhuti V, Pang CL, Tenant S, Taylor J, Hyde C, Roobottom C. Prospective intra-individual comparison of standard dose versus reduced-dose thoracic CT using hybrid and pure iterative reconstruction in a follow-up cohort of pulmonary nodules—Effect of detectability of pulmonary nodules with lowering dose based on nodule size, type and body mass index. European Journal of Radiology 91:130-141 01 Jun 2017


Fortnum H, Ukoumunne OC, Hyde C, Taylor RS, Ozolins M, Errington S, Zhelev Z, Pritchard C, Benton C, Moody J, Cocking L, Watson J, Roberts S. A programme of studies including assessment of diagnostic accuracy of school hearing screening tests and a cost-effectiveness model of school entry hearing screening programmes. Health Technol Assess 2016;20(36). doi:

Iyengar SS, Morgan-Hughes G, Ukoumunne O, Clayton B, Davies EJ, Nikolaou V, Hyde CJ, Shore AC, Roobottom CA. Diagnostic accuracy of high-definition CT coronary angiography in high-risk patients Clinical Radiology 2016;71(2):151-158. DOI:

CONFERENCE ABSTRACT: Jennison C, Jobling A, Pearson E, Hattersley A, Gray A, Hyde C. Assessing the benefits of a stratified treatment strategy which improves average HbA1c in a proportion of patients with Type 2 diabetes: a MASTERMIND study. Diabetic Medicine 2016;33:23.

Rachuba S, Salmon A, Zhelev Z, Pitt M. Simulating single test rule-out strategies for chest pain patients at emergency departments. In Anagnostou A, Hoad K, Kunc M eds. Proceedings of the Operational Research Society Simulation Workshop 2016 (SW16)

CONFERENCE ABSTRACT: Peters JL, Anderson R, Shields BM, King S, Hudson M, Shepherd M, McDonald TJ, Pearson E, Hattersley AT, Hyde C.  Strategies to identify individuals with MODY: results of a health economic model. Diabetic Medicine 2016;33:158.

Shepherd M, Shields B, Hammersley S, Hudson M, McDonald TJ, Colclough K, Oram RA, Knight B, Hyde C, Cox J et al. Systematic population screening, using biomarkers and genetic testing, identifies 2.5% of the U.K. pediatric diabetes population with monogenic diabetes. Diabetes Care 2016;39(11):1879-1888. DOI:

Zhelev Z, Abbott R, Rogers M, Fleming S, Patterson A, Hamilton WT, Heaton J, Coon JT, Vaidya B, Hyde C. Effectiveness of interventions to reduce ordering of thyroid function tests: A systematic review. BMJ Open  2016;6:e010065  doi:10.1136/bmjopen-2015-010065

CONFERENCE ABSTRACT: Zhelev Z, Patel K, Youngman E, Peters J, Lowe J, Cooper C, Shields B, Hattersley A, Hyde C.  Autoantibody status as a predictor of future insulin deficiency in patients with diabetes: a systematic review. Diabetic Medicine 2016;33:93.


Hunt HA, Stanworth S, Curry N, Wolley T, Cooper C, Ukoumunne O, Zhelev Z, Hyde C. Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) for trauma-induced coagulopathy in adult trauma patients with bleeding. Cochrane Database of Systematic Reviews 2015, (2). doi:10.1002/14651858.CD010438.pub2

Marshall MJ, Smart NJ, Hyde C, Winyard PG, Shaw AM, Daniels IR. Biomarkers for diagnosis of acute appendicitis in adults (Protocol). Cochrane Database of Systematic Reviews 2015, Issue 3. Art. No.: CD011592. DOI: 10.1002/14651858.CD011592.

McCleery J, Morgan S, Bradley KM, Noel-Storr AH, Ansorge O, Hyde C. Dopamine transporter imaging for the diagnosis of dementia with Lewy bodies. Cochrane Database of Systematic Reviews 2015, (1). doi:10.1002/14651858.CD010633.pub2

Peters JL, Cooper C, Buchanan J. Evidence used in model-based economic evaluations for evaluating pharmacogenetics and pharmacogenomics tests: a systematic review protocol. BMJ Open 2015 5:e008465 doi:10.1136/bmjopen-2015-008465

Shields BM, Peters JL, Cooper C, Lowe J, Knight BA, Powell RJ, Hyde CJ, Hattersley AT. Can clinical features be used to differentiate Type 1 from Type 2 diabetes? A systematic review of the literature. BMJ Open 2015 5:e009088 doi:10.1136/bmjopen-2015-009088

Smailagic N, Vacante M, Hyde C, Martin S, Ukoumunne O, Sachpekidis C. F-18-FDG PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database of Systematic Reviews 2015;(1). doi:10.1002/14651858.CD010632.pub2

Whiting PF, Davenport C, Jameson C, Burke M, Sterne JAC, Hyde C, Ben-Shlomo Y. How well do health professionals interpret diagnostic information? A systematic review. BMJ Open 2015, 5(7). doi:10.1136/bmjopen-2015-008155

Zhelev Z, Hyde C, Fitzgerald JE, Ukoumunne O, Briscoe S, Chisnell J, Grigore B. Tests for screening for hearing loss in children about to start school (Protocol). Cochrane Database of Systematic Reviews 2015, Issue 11. Art. No.: CD011951. DOI: 10.1002/14651858.CD011951.

Zhelev Z, Hyde C, Youngman E, Rogers M, Fleming S, Slade T, Coelho H, Jones-Hughes T, Nikolaou V. Diagnostic accuracy of single baseline measurement of Elecsys troponin T high-sensitive assay for diagnosis of acute myocardial infarction in emergency department: systematic review and meta-analysis. BMJ 2015; 350:h15. doi:

2014 and prior


Gopalakrishna G, Mustafa RA, Davenport C, Scholten RJPM, Hyde C, Brozek J, Schünemann HJ, Bossuyt PMM, Leeflang MMG, Langendam MW. Applying Grading of Recommendations Assessment, Development and Evaluation (GRADE) to diagnostic tests was challenging but doable. J Clin Epidemiol 2014; 67(7):760-768. doi:10.1016/j.jclinepi.2014.01.006

Hardwick R, Heaton J, Griffiths G, Vaidya B, Child S, Fleming S, Hamilton WT, Tomlinson J, Zhelev Z, Patterson A, Hyde C. Exploring reasons for variation in ordering thyroid function tests in primary care: a qualitative study. Qual Prim Care. 2014;22(6):256-61.

Noel-Storr AH, McCleery JM, Richard E, Ritchie CW, Flicker L, Cullum SJ, Davis D, Quinn TJ, Hyde C, Rutjes AWS, Smailagic N, Marcus S, Black S, Blennow K, Brayne C, Fiorivanti M, Johnson JK, Köpke S, Schneider LS, Simmons A, Mattsson N, Zetterberg H, Bossuyt PMM, Wilcock G, McShane R. Reporting standards for studies of diagnostic test accuracy in dementia: The STARDdem Initiative. Neurology 2014, 83(4), 364-373. doi:10.1212/WNL.0000000000000621

Walker G, Yip S, Zhelev Z, Henschke N. Prehospital stroke scales as screening tools for early identification of stroke and transient ischemic attack (Protocol). Cochrane Database of Systematic Reviews 2014, Issue 12. Art. No.: CD011427. DOI: 10.1002/14651858.CD011427.

Zhang S, Smailagic N, Hyde C, Noel-Storr AH, Takwoingi Y, McShane R, Feng J. 11C-PIB-PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database of Systematic  Reviews 2014;(7) DOI: 10.1002/14651858.CD010386.


Davis DH, Creavin ST, Noel-Storr A, Quinn TJ, Smailagic N, Hyde C, Brayne C, McShane R, Cullum S. Neuropsychological tests for the diagnosis of Alzheimer's disease dementia and other dementias: a generic protocol for cross-sectional and delayed-verification studies. Cochrane Database Syst Rev 2013, (3). doi:10.1002/14651858.CD010460

Hunt HA, Hyde CJ, Stanworth S, Curry N, Perel P, Woolley T, Ukoumunne O. Thromboelastography (TEG) and thromboelastometry (ROTEM) for trauma-induced coagulopathy in adult trauma patients with bleeding [Protocol]. Cochrane Database of Systematic Reviews 2013. doi:10.1002/14651858.CD010438

Hunt HA, Hyde CJ, Pearson M. Realist synthesis – what is it and how could it add value to the diagnosis of dementia in primary care? Poster at Methods for Evaluating Medical Tests and Biomarkers Symposium 2013. University of Birmingham, UK.

Peters JL, Anderson R, Hyde C. Development of an economic evaluation of diagnostic strategies: the case of monogenic diabetes. BMJ Open2013 3:e002905 doi:10.1136/bmjopen-2013-002905

Zhelev Z, Garside R, Hyde C. A qualitative study into the difficulties experienced by healthcare decision makers when reading a Cochrane diagnostic test accuracy review. Syst Rev 2013;2:32. doi:10.1186/2046-4053-2-32


Shields B, Peters J, Cooper C, Powell R, Knight B, Hyde C, Hattersley A. Identifying clinical criteria to predict type 1 diabetes, as defined by absolute insulin deficiency: a systematic review protocol. BMJ Open 2012 2:e002309 doi:10.1136/bmjopen-2012-002309.

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