Professor Nigel Cairns
Professor of Neuropathology
N.J.Cairns@exeter.ac.uk
7603
01392 727603
Living Systems Institute T05.15
Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD
Overview
Professor Cairns joined the College of Medicine and Health and the Living Systems Institute in 2019. For more than two decades he has focused on the neuropathology and pathogenesis of neurological diseases including Alzheimer and Parkinson diseases and a group of disorders called the frontotemporal diseases. He has focused on characterizing the misfolded proteins within inclusion bodies of these diseases. One of these proteins, a DNA-binding protein, called TDP-43 becomes abnormal in most patients with frontotemporal disease and/or motor neuron disease (MND). His lab was the first to discover a defect in the TDP-43 gene, a novel cause of MND. This discovery led to the development of a diagnostic test which is in use in the clinic today. Subsequently, he has investigated small molecules that bind to abnormal TDP-43; firstly, as potential imaging agents and secondly as drugs that may slow down or stop the build-up of misfolded proteins within neurons. At Exeter he plans to validate the usefulness of TDP-43-modulating drugs in cell and animal models and, hopefully, progress these exciting new molecules to clinical trials.
Qualifications
- BA
- BSc
- PhD
- FRCPath
Grants/Funding:
- University of Exeter
Links
Research
Research interests
Professor Cairns has a background in experimental neuropathology and his research career has focused principally on the neuropathology and pathogenesis of neurodegenerative diseases including Alzheimer disease, Parkinson disease and the frontotemporal diseases. Within the University of Exeter Medical School, he leads a team studying the misfolding of proteins that accumulate as inclusion bodies within neurons and glia of several neurodegenerative diseases with the aim of understanding how protein misfolding may lead to loss of function, cell death and clinical disease. His team's research specialisms include the monitoring and assessment of protein misfolding, cell function and viability using cryo-electron microscopy in collaboration with Drs Vicki Gold and Bertram Daum and in vitro approaches including the monitoring and manipulation of misfolded proteins using non-cell- and cell-based assays in collaboration with Professor Noel Morgan.
Research projects
Current Projects:
- Atomic characterization of misfolded proteins in Lewy body and related diseases.
- Modelling and modulating the misfolding of proteins in neurodegenerative disease.
Publications
Journal articles
Creese B (In Press). A Data-Driven Examination of Apathy and Depressive Symptoms in Dementia with Independent Replication. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Martin WRW, Younce JR, Campbell MC, Racette BA, Norris SA, Ushe M, Criswell S, Davis AA, Alfradique-Dunham I, Maiti B, et al (2023). Neocortical Lewy Body Pathology Parallels Parkinson's Dementia, but Not Always. Ann Neurol, 93(1), 184-195. Abstract. Author URL.
Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, et al (2023). Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimers Dement, 19(2), 632-645. Abstract. Author URL.
Ge YJ, Ou YN, Deng YT, Wu BS, Yang L, Zhang YR, Chen SD, Huang YY, Dong Q, Tan L, et al (2023). Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data from Brain and Blood. Biological Psychiatry, 93(9), 770-779. Abstract.
Massett RJ, Maher AS, Imms PE, Amgalan A, Chaudhari NN, Chowdhury NF, Irimia A, Weiner MW, Aisen P, Petersen R, et al (2023). Regional Neuroanatomic Effects on Brain Age Inferred Using Magnetic Resonance Imaging and Ridge Regression. Journals of Gerontology - Series a Biological Sciences and Medical Sciences, 78(6), 872-881. Abstract.
Jiang Y, Zhou X, Wong HY, Ouyang L, Ip FCF, Chau VMN, Lau SF, Wu W, Wong DYK, Seo H, et al (2022). An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease. Nature Aging, 2(7), 616-634. Abstract.
Yan T, Liang J, Gao J, Wang L, Fujioka H, Weiner MW, Schuff N, Rosen HJ, Miller BL, Perry D, et al (2022). Author Correction: FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease (Nature Communications, (2020), 11, 1, (411), 10.1038/s41467-019-13962-0). Nature Communications, 13(1). Abstract.
Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, et al (2022). Autosomal dominant and sporadic late onset Alzheimer's disease share a common in vivo pathophysiology. Brain, 145(10), 3594-3607. Abstract. Author URL.
Duong MT, Das SR, Lyu X, Xie L, Richardson H, Xie SX, Yushkevich PA, Weiner M, Aisen P, Petersen R, et al (2022). Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease. Nature Communications, 13(1). Abstract.
Farrell K, Kim SH, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, et al (2022). Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica, 143(1), 33-53. Abstract.
Jiang J, Sheng C, Chen G, Liu C, Jin S, Li L, Jiang X, Han Y, Weiner MW, Aisen P, et al (2022). Glucose metabolism patterns: a potential index to characterize brain ageing and predict high conversion risk into cognitive impairment. GeroScience, 44(4), 2319-2336. Abstract.
Heath L, Earls JC, Magis AT, Kornilov SA, Lovejoy JC, Funk CC, Rappaport N, Logsdon BA, Mangravite LM, Kunkle BW, et al (2022). Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90. Scientific Reports, 12(1). Abstract.
Miller RL, Dhavale DD, O'Shea JY, Andruska KM, Liu J, Franklin EE, Buddhala C, Loftin SK, Cirrito JR, Perrin RJ, et al (2022). Quantifying regional α-synuclein, amyloid β, and tau accumulation in lewy body dementia. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 9(2), 106-121. Author URL.
Fathian A, Jamali Y, Raoufy MR, Weiner MW, Schuf N, Rosen HJ, Miller BL, Neylan T, Hayes J, Finley S, et al (2022). The trend of disruption in the functional brain network topology of Alzheimer’s disease. Scientific Reports, 12(1). Abstract.
Yang Z, Nasrallah IM, Shou H, Wen J, Doshi J, Habes M, Erus G, Abdulkadir A, Resnick SM, Albert MS, et al (2021). A deep learning framework identifies dimensional representations of Alzheimer’s Disease from brain structure. Nature Communications, 12(1). Abstract.
Gonneaud J, Baria AT, Pichet Binette A, Gordon BA, Chhatwal JP, Cruchaga C, Jucker M, Levin J, Salloway S, Farlow M, et al (2021). Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease. Nature Communications, 12(1). Abstract.
Knopman DS, Lundt ES, Therneau TM, Albertson SM, Gunter JL, Senjem ML, Schwarz CG, Mielke MM, MacHulda MM, Boeve BF, et al (2021). Association of Initial β-Amyloid Levels with Subsequent Flortaucipir Positron Emission Tomography Changes in Persons without Cognitive Impairment. JAMA Neurology, 78(2), 217-228. Abstract.
Vogel JW, Iturria-Medina Y, Strandberg OT, Smith R, Levitis E, Evans AC, Hansson O, Weiner M, Aisen P, Petersen R, et al (2021). Author Correction: Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease (Nature Communications, (2020), 11, 1, (2612), 10.1038/s41467-020-15701-2). Nature Communications, 12(1). Abstract.
Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, et al (2021). Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta Neuropathol, 142(4), 689-706. Abstract. Author URL.
Chung Y, Lee H, Weiner MW, Aisen P, Petersen R, Jack CR, Jagust W, Trojanowki JQ, Toga AW, Beckett L, et al (2021). Correlation between Alzheimer’s disease and type 2 diabetes using non-negative matrix factorization. Scientific Reports, 11(1). Abstract.
Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, et al (2021). Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. J Neuropathol Exp Neurol, 80(2), 102-111. Abstract. Author URL.
Reus LM, Pasaniuc B, Posthuma D, Boltz T, Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JBJ, et al (2021). Gene Expression Imputation Across Multiple Tissue Types Provides Insight into the Genetic Architecture of Frontotemporal Dementia and its Clinical Subtypes. Biological Psychiatry, 89(8), 825-835. Abstract.
Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, et al (2021). Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nat Genet, 53(3), 294-303. Abstract. Author URL.
Arezoumandan S, Cai X, Kalkarni P, Davis SA, Wilson K, Ferris CF, Cairns NJ, Gitcho MA (2021). Hippocampal neurobiology and function in an aged mouse model of TDP-43 proteinopathy in an APP/PSEN1 background. Neurosci Lett, 758 Abstract. Author URL.
Martin WRW, Miles M, Zhong Q, Hartlein J, Racette BA, Norris SA, Ushe M, Maiti B, Criswell S, Davis AA, et al (2021). Is Levodopa Response a Valid Indicator of Parkinson's Disease?. Movement Disorders, 36(4), 948-954. Abstract.
Shen XN, Huang YY, Chen SD, Guo Y, Tan L, Dong Q, Yu JT, Weiner MW, Aisen P, Petersen R, et al (2021). Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer’s amyloid, tau and FDG PET status. Translational Psychiatry, 11(1). Abstract.
Chen SD, Lu JY, Li HQ, Yang YX, Jiang JH, Cui M, Zuo CT, Tan L, Dong Q, Yu JT, et al (2021). Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study. Translational Psychiatry, 11(1). Abstract.
Das SR, Lyu X, Duong MT, Xie L, McCollum L, de Flores R, DiCalogero M, Irwin DJ, Dickerson BC, Nasrallah IM, et al (2021). Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease. Annals of Neurology, 90(5), 751-762. Abstract.
Bieniek KF, Cairns NJ, Crary JF, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel J-P, et al (2021). The Second NINDS/NIBIB Consensus Meeting to Define Neuropathological Criteria for the Diagnosis of Chronic Traumatic Encephalopathy. J Neuropathol Exp Neurol, 80(3), 210-219. Abstract. Author URL.
Squillario M, Abate G, Tomasi F, Tozzo V, Barla A, Uberti D, Weiner MW, Aisen P, Petersen R, Clifford JR, et al (2020). A telescope GWAS analysis strategy, based on SNPs-genes-pathways ensamble and on multivariate algorithms, to characterize late onset Alzheimer’s disease. Scientific Reports, 10(1). Abstract.
Orme T, Hernandez D, Ross OA, Kun-Rodrigues C, Darwent L, Shepherd CE, Parkkinen L, Ansorge O, Clark L, Honig LS, et al (2020). Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta Neuropathologica Communications, 8(1). Abstract.
Chen CD, Holden TR, Gordon BA, Franklin EE, Li Y, Coble DW, Luo H, Bateman RJ, Dominantly Inherited Alzheimer Network (DIAN) and for the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU), Ances BM, et al (2020). Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease. Ann Clin Transl Neurol, 7(12), 2475-2480. Abstract. Author URL.
Park YH, Hodges A, Simmons A, Lovestone S, Weiner MW, Kim SY, Saykin AJ, Nho K, Aisen P, Petersen R, et al (2020). Association of blood-based transcriptional risk scores with biomarkers for Alzheimer disease. Neurology: Genetics, 6(6). Abstract.
Hett K, Ta VT, Catheline G, Tourdias T, Manjón JV, Coupé P, Weiner MW, Aisen P, Petersen R, Jack CR, et al (2020). Author Correction: Multimodal hippocampal subfield grading for Alzheimer’s disease classification (Scientific Reports, (2019), 9, 1, (13845), 10.1038/s41598-019-49970-9). Scientific Reports, 10(1). Abstract.
Shen X, Ma S, Vemuri P, Simon G, Weiner MW, Aisen P, Petersen R, Jack CR, Saykin AJ, Jagust W, et al (2020). Challenges and Opportunities with Causal Discovery Algorithms: Application to Alzheimer’s Pathophysiology. Scientific Reports, 10(1). Abstract.
Morris GM, Holden TR, Weng H, Xiong C, Coble DW, Cairns NJ, Morris JC (2020). Comparative Performance and Neuropathologic Validation of the AD8 Dementia Screening Instrument. Alzheimer Dis Assoc Disord, 34(2), 112-117. Abstract. Author URL.
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, et al (2020). Correction to: a nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathol, 139(5), 959-962. Abstract. Author URL.
Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, et al (2020). Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications, 11(1). Abstract.
Yan T, Liang J, Gao J, Wang L, Fujioka H, Weiner MW, Schuff N, Rosen HJ, Miller BL, Perry D, et al (2020). FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease. Nature Communications, 11(1). Abstract.
Liscic RM, Alberici A, Cairns NJ, Romano M, Buratti E (2020). From basic research to the clinic: Innovative therapies for ALS and FTD in the pipeline. Molecular Neurodegeneration, 15(1). Abstract.
Franzmeier N, Neitzel J, Rubinski A, Smith R, Strandberg O, Ossenkoppele R, Hansson O, Ewers M, Weiner M, Aisen P, et al (2020). Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease. Nature Communications, 11(1). Abstract.
Ibanez L, Bahena JA, Yang C, Dube U, Farias FHG, Budde JP, Bergmann K, Brenner-Webster C, Morris JC, Perrin RJ, et al (2020). Functional genomic analyses uncover APOE-mediated regulation of brain and cerebrospinal fluid beta-amyloid levels in Parkinson disease. Acta Neuropathologica Communications, 8(1). Abstract.
Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (2020). Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways. Brain Communications, 2(2). Abstract.
Franzmeier N, Suárez-Calvet M, Frontzkowski L, Moore A, Hohman TJ, Morenas-Rodriguez E, Nuscher B, Shaw L, Trojanowski JQ, Dichgans M, et al (2020). Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration. Molecular Neurodegeneration, 15(1). Abstract.
Gao Y, Wang T, Yu X, Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JBJ, Dobson-Stone C, et al (2020). Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis. Scientific Reports, 10(1). Abstract.
Chung EJ, Kim SJ, Kim E-J, Ahn JW, Huh GY, Cho HJ, Cairns NJ (2020). Neuropathological findings in a South Korean patient with Perry syndrome. Clin Neuropathol, 39(2), 80-85. Abstract. Author URL.
Campbell MC, Myers PS, Weigand AJ, Foster ER, Cairns NJ, Jackson JJ, Lessov-Schlaggar CN, Perlmutter JS (2020). Parkinson disease clinical subtypes: key features & clinical milestones. Annals of Clinical and Translational Neurology, 7(8), 1272-1283. Abstract.
Vogel JW, Iturria-Medina Y, Strandberg OT, Smith R, Levitis E, Evans AC, Hansson O, Weiner M, Aisen P, Petersen R, et al (2020). Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease. Nature Communications, 11(1). Abstract.
Mock C, Teylan M, Beecham G, Besser L, Cairns NJ, Crary JF, Katsumata Y, Nelson PT, Kukull W (2020). The Utility of the National Alzheimer's Coordinating Center's Database for the Rapid Assessment of Evolving Neuropathologic Conditions. Alzheimer Dis Assoc Disord, 34(2), 105-111. Abstract. Author URL.
Shen X-N, Miao D, Li J-Q, Tan C-C, Cao X-P, Tan L, Yu J-T, Weiner MW, Aisen P, Weiner M, et al (2019). <i>MAPT</i> rs242557 variant is associated with hippocampus tau uptake on <SUP>18</SUP>F-AV-1451 PET in non-demented elders. AGING-US, 11(3), 874-884. Author URL.
Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, et al (2019). A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports, 13(5), 939-955. Abstract. Author URL.
Kundu S, Lukemire J, Wang Y, Guo Y, Weiner MW, Schuff N, Rosen HJ, Miller BL, Neylan T, Hayes J, et al (2019). A Novel Joint Brain Network Analysis Using Longitudinal Alzheimer’s Disease Data. Scientific Reports, 9(1). Abstract.
Ishida T, Tokuda K, Hisaka A, Honma M, Kijima S, Takatoku H, Iwatsubo T, Moritoyo T, Suzuki H, Weiner MW, et al (2019). A Novel Method to Estimate Long-Term Chronological Changes from Fragmented Observations in Disease Progression. CLINICAL PHARMACOLOGY & THERAPEUTICS, 105(2), 436-447. Author URL.
Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, et al (2019). A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiol Aging, 75, 223.e1-223.e10. Abstract. Author URL.
Kuang L, Han X, Chen K, Caselli RJ, Reiman EM, Wang Y, Weiner MW, Aisen P, Weiner M, Petersen R, et al (2019). A concise and persistent feature to study brain resting-state network dynamics: Findings from the Alzheimer's Disease Neuroimaging Initiative. HUMAN BRAIN MAPPING, 40(4), 1062-1081. Author URL.
Nathoo FS, Kong L, Zhu H, Weiner MW, Aisen P, Weiner M, Aisen P, Petersen R, Jack CRJ, Jagust W, et al (2019). A review of statistical methods in imaging genetics. CANADIAN JOURNAL OF STATISTICS-REVUE CANADIENNE DE STATISTIQUE, 47(1), 108-131. Author URL.
Hu Y, Li M, Lu Q, Weng H, Wang J, Zekavat SM, Yu Z, Li B, Gu J, Muchnik S, et al (2019). A statistical framework for cross-tissue transcriptome-wide association analysis. NATURE GENETICS, 51(3), 568-+. Author URL.
Royall DR, Palmer RF, Weiner MW, Aisen P, Weiner M, Petersen R, Jack CRJ, Jagust W, Trojanowki JQ, Toga AW, et al (2019). A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative. JOURNAL OF ALZHEIMERS DISEASE, 67(1), 67-79. Author URL.
De Carli F, Nobili F, Pagani M, Bauckneht M, Massa F, Grazzini M, Jonsson C, Peira E, Morbelli S, Arnaldi D, et al (2019). Accuracy and generalization capability of an automatic method for the detection of typical brain hypometabolism in prodromal Alzheimer disease. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 46(2), 334-347. Author URL.
Palmqvist S, Insel PS, Zetterberg H, Blennow K, Brix B, Stomrud E, Mattsson N, Hansson O, Weiner MW, Aisen P, et al (2019). Accurate risk estimation of β-amyloid positivity to identify prodromal Alzheimer's disease: Cross-validation study of practical algorithms. ALZHEIMERS & DEMENTIA, 15(2), 194-204. Author URL.
MahmoudianDehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G, Louie G, Kueider-Paisley A, Moseley MA, Thompson JW, et al (2019). Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome. ALZHEIMERS & DEMENTIA, 15(1), 76-92. Author URL.
Nho K, Kueider-Paisley A, MahmoudianDehkordi S, Arnold M, Risacher SL, Louie G, Blach C, Baillie R, Han X, Kastenmueller G, et al (2019). Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers. ALZHEIMERS & DEMENTIA, 15(2), 232-244. Author URL.
Avants BB, Hutchison RM, Mikulskis A, Salinas-Valenzuela C, Hargreaves R, Beaver J, Chiao P, Weiner MW, Aisen P, Weiner M, et al (2019). Amyloid beta-positive subjects exhibit longitudinal network-specific reductions in spontaneous brain activity. NEUROBIOLOGY OF AGING, 74, 191-201. Author URL.
Ma Y, Jun GR, Zhang X, Chung J, No AC, Chen Y, Bellenguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, et al (2019). Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype. JAMA NEUROLOGY, 76(9), 1099-1108. Author URL.
Ye X, Zhou W, Zhang J, Weiner MW, Aisen P, Weiner M, Petersen R, Jack CRJ, Jagust W, Trojanowki JQ, et al (2019). Association of CSF CD40 levels and synaptic degeneration across the Alzheimer's disease spectrum. NEUROSCIENCE LETTERS, 694, 41-45. Author URL.
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, et al (2019). Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet, 51(9), 1423-1424. Abstract. Author URL.
Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, et al (2019). Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease. Brain, 142(5), 1429-1440. Abstract.
Armstrong RA, McKee AC, Stein TD, Alvarez VE, Cairns NJ (2019). Cortical degeneration in chronic traumatic encephalopathy and Alzheimer's disease neuropathologic change. Neurol Sci, 40(3), 529-533. Abstract. Author URL.
Kulason S, Tward DJ, Brown T, Sicat CS, Liu C-F, Ratnanather JT, Younes L, Bakker A, Gallagher M, Albert M, et al (2019). Cortical thickness atrophy in the transentorhinal cortex in mild cognitive impairment. NEUROIMAGE-CLINICAL, 21 Author URL.
Ma Y, Jun GR, Chung J, Zhang X, Kunkle BW, Naj AC, White CC, Bennett DA, De Jager PL, Mayeux R, et al (2019). CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease. AGING CELL, 18(4). Author URL.
Zavaliangos-Petropulu A, Nir TM, Thomopoulos SI, Reid RI, Bernstein MA, Borowski B, Jack CRJ, Weiner MW, Jahanshad N, Thompson PM, et al (2019). Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: the Updated Multi-protocol Approach in ADNI3. FRONTIERS IN NEUROINFORMATICS, 13 Author URL.
Venkatraghavan V, Bron EE, Niessen WJ, Klein S, Weiner MW, Aisen P, Weiner M, Petersen R, Jack CRJ, Jagust W, et al (2019). Disease progression timeline estimation for Alzheimer's disease using discriminative event based modeling. NEUROIMAGE, 186, 518-532. Author URL.
Barroeta-Espar I, Weinstock LD, Perez-Nievas BG, Meltzer AC, Siao Tick Chong M, Amaral AC, Murray ME, Moulder KL, Morris JC, Cairns NJ, et al (2019). Distinct cytokine profiles in human brains resilient to Alzheimer's pathology. Neurobiol Dis, 121, 327-337. Abstract. Author URL.
Zhou H, Jiang J, Lu J, Wang M, Zhang H, Zuo C, Weiner MW, Aisen P, Petersen R, Jack CRJ, et al (2019). Dual-Model Radiomic Biomarkers Predict Development of Mild Cognitive Impairment Progression to Alzheimer's Disease. FRONTIERS IN NEUROSCIENCE, 12 Author URL.
Ding X, Charnigo RJ, Schmitt FA, Kryscio RJ, Abner EL, Weiner MW, Aisen P, Weiner M, Petersen R, Jack CRJ, et al (2019). Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI. PLOS ONE, 14(2). Author URL.
Pizzi SD, Punzi M, Sensi SL, Weiner MW, Aisen P, Weiner M, Petersen R, Jack CRJ, Jagust W, Trojanowki JQ, et al (2019). Functional signature of conversion of patients with mild cognitive impairment. NEUROBIOLOGY OF AGING, 74, 21-37. Author URL.
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, et al (2019). Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet, 51(3), 414-430. Abstract. Author URL.
Bonham LW, Steele NZR, Karch CM, Broce I, Geier EG, Wen NL, Momeni P, Hardy J, Miller ZA, Gorno-Tempini ML, et al (2019). Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia. SCIENTIFIC REPORTS, 9 Author URL.
Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, et al (2019). Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol, 137(6), 879-899. Abstract. Author URL.
Guerreiro R, Escott-Price V, Hernandez DG, Kun-Rodrigues C, Ross OA, Orme T, Neto JL, Carmona S, Dehghani N, Eicher JD, et al (2019). Heritability and genetic variance of dementia with Lewy bodies. Neurobiol Dis, 127, 492-501. Abstract. Author URL.
Swarup V, Hinz FI, Rexach JE, Noguchi K-I, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, et al (2019). Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. NATURE MEDICINE, 25(1), 152-+. Author URL.
Munir M, Ursenbach J, Reid M, Sah RG, Wang M, Sitaram A, Aftab A, Tariq S, Zamboni G, Griffanti L, et al (2019). Longitudinal Brain Atrophy Rates in Transient Ischemic Attack and Minor Ischemic Stroke Patients and Cognitive Profiles. FRONTIERS IN NEUROLOGY, 10 Author URL.
Wang X, Ren P, Baran TM, Raizada RDS, Mapstone M, Lin F, Weiner MW, Aisen P, Weiner M, Aisen P, et al (2019). Longitudinal Functional Brain Mapping in Supernormals. CEREBRAL CORTEX, 29(1), 242-252. Author URL.
Dalca AV, Bouman KL, Freeman WT, Rost NS, Sabuncu MR, Golland P, Weiner MW, Aisen P, Weiner M, Aisen P, et al (2019). Medical Image Imputation from Image Collections. IEEE TRANSACTIONS ON MEDICAL IMAGING, 38(2), 504-514. Author URL.
Hett K, Ta VT, Catheline G, Tourdias T, Manjón JV, Coupé P, Weiner MW, Aisen P, Petersen R, Jack CR, et al (2019). Multimodal Hippocampal Subfield Grading for Alzheimer’s Disease Classification. Scientific Reports, 9(1). Abstract.
Bonvicini C, Scassellati C, Benussi L, Di Maria E, Maj C, Ciani M, Fostinelli S, Mega A, Bocchetta M, Lanzi G, et al (2019). Next Generation Sequencing Analysis in Early Onset Dementia Patients. JOURNAL OF ALZHEIMERS DISEASE, 67(1), 243-256. Author URL.
Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N, Giusti-Rodriguez P, et al (2019). Non-coding variability at the <i>APOE</i> locus contributes to the Alzheimer's risk. NATURE COMMUNICATIONS, 10 Author URL.
Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Su BW, Song E-S, Cairns NJ, Kotzbauer PT, Diamond MI (2019). Parkinson's disease and multiple system atrophy have distinct α-synuclein seed characteristics. J Biol Chem, 294(3), 1045-1058. Abstract. Author URL.
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Chen CH, Peng Q, Schork AJ, Lo MT, Fan CC, Wang Y, Desikan RS, Bettella F, Hagler DJ, Westlye LT, et al (2015). Large-scale genomics unveil polygenic architecture of human cortical surface area. Nature Communications, 6 Abstract.
Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, et al (2015). Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's and Dementia Abstract.
Cairns NJ, Perrin RJ, Franklin EE, Carter D, Vincent B, Xie M, Bateman RJ, Benzinger T, Friedrichsen K, Brooks WS, et al (2015). Neuropathologic assessment of participants in two multi-center longitudinal observational studies: the Alzheimer Disease Neuroimaging Initiative (ADNI) and the Dominantly Inherited Alzheimer Network (DIAN). Neuropathology, 35(4), 390-400. Abstract. Author URL.
Hassenstab J, Monsell SE, Mock C, Roe CM, Cairns NJ, Morris JC, Kukull W (2015). Neuropsychological markers of cognitive decline in persons with Alzheimer disease neuropathology. Journal of Neuropathology and Experimental Neurology, 74(11), 1086-1092. Abstract.
Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, et al (2015). PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathol, 129(5), 757-762. Author URL.
Su Y, Blazey TM, Snyder AZ, Raichle ME, Marcus DS, Ances BM, Bateman RJ, Cairns NJ, Aldea P, Cash L, et al (2015). Partial volume correction in quantitative amyloid imaging. Neuroimage, 107, 55-64. Abstract. Author URL.
Shim YS, Yang D-W, Roe CM, Coats MA, Benzinger TL, Xiong C, Galvin JE, Cairns NJ, Morris JC (2015). Pathological correlates of white matter hyperintensities on magnetic resonance imaging. Dement Geriatr Cogn Disord, 39(1-2), 92-104. Abstract. Author URL.
Wang L-S, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JDG, Cannon-Albright L, Baldwin CT, Zetterberg H, et al (2015). Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol, 72(2), 209-216. Abstract. Author URL.
Abner EL, Schmitt FA, Nelson PT, Lou W, Wan L, Gauriglia R, Dodge HH, Woltjer RL, Yu L, Bennett DA, et al (2015). The Statistical Modeling of Aging and Risk of Transition Project: Data Collection and Harmonization Across 11 Longitudinal Cohort Studies of Aging, Cognition, and Dementia. Obs Stud, 1(2015), 56-73. Abstract. Author URL.
McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Dirk Keene C, Litvan I, Perl DP, Stein TD, Vonsattel J-P, Stewart W, et al (2015). The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Acta Neuropathologica, 1-12. Abstract.
Ghoshal N, Perry A, McKeel D, Schmidt RE, Carter D, Norton J, Zou W-Q, Xiao X, Puoti G, Notari S, et al (2015). Variably Protease-sensitive Prionopathy in an Apparent Cognitively Normal 93-Year-Old. Alzheimer Dis Assoc Disord, 29(2), 173-176. Author URL.
Hurth K, Tarawneh R, Ghoshal N, Benzinger TLS, Clifford DB, Geschwind M, Morris JC, Galvin JE, Schmidt RE, Cairns NJ, et al (2015). Whipple's disease masquerades as dementia with Lewy bodies. Alzheimer Dis Assoc Disord, 29(1), 85-89. Author URL.
Armstrong RA, Kotzbauer PT, Perlmutter JS, Campbell MC, Hurth KM, Schmidt RE, Cairns NJ (2014). A quantitative study of α-synuclein pathology in fifteen cases of dementia associated with Parkinson disease. J Neural Transm (Vienna), 121(2), 171-181. Abstract. Author URL.
Sundaram GSM, Garai K, Rath NP, Yan P, Cirrito JR, Cairns NJ, Lee J-M, Sharma V (2014). Characterization of a brain permeant fluorescent molecule and visualization of Aβ parenchymal plaques, using real-time multiphoton imaging in transgenic mice. Org Lett, 16(14), 3640-3643. Abstract. Author URL.
Toledo JB, Cairns NJ, Da X, Chen K, Carter D, Fleisher A, Householder E, Ayutyanont N, Roontiva A, Bauer RJ, et al (2014). Clinical and multimodal biomarker correlates of ADNI neuropathological findings. Acta Neuropathologica Communications, 2(1). Abstract.
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang L-S, et al (2014). Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol, 71(11), 1394-1404. Abstract. Author URL.
Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JBJ, Dobson-Stone C, Brooks WS, Schofield PR, Halliday GM, et al (2014). Frontotemporal dementia and its subtypes: a genome-wide association study. Lancet Neurol, 13(7), 686-699. Abstract. Author URL.
Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, et al (2014). Functional connectivity in autosomal dominant and late-onset Alzheimer disease. JAMA Neurol, 71(9), 1111-1122. Abstract. Author URL.
Bras J, Guerreiro R, Darwent L, Parkkinen L, Ansorge O, Escott-Price V, Hernandez DG, Nalls MA, Clark LN, Honig LS, et al (2014). Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Human molecular genetics, 23(23), 6139-6146. Abstract.
Ringman JM, Goate A, Masters CL, Cairns NJ, Danek A, Graff-Radford N, Ghetti B, Morris JC, Dominantly Inherited Alzheimer Network (2014). Genetic heterogeneity in Alzheimer disease and implications for treatment strategies. Curr Neurol Neurosci Rep, 14(11). Abstract. Author URL.
Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TLS, Ghetti B, Martins RN, Masters CL, Mayeux R, et al (2014). Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Sci Transl Med, 6(226). Abstract. Author URL.
Monsell SE, Mock C, Hassenstab J, Roe CM, Cairns NJ, Morris JC, Kukull W (2014). Neuropsychological changes in asymptomatic persons with Alzheimer disease neuropathology. Neurology, 83(5), 434-440. Abstract.
Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, et al (2014). Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol, 128(6), 755-766. Abstract. Author URL.
Holmes BB, Furman JL, Mahan TE, Yamasaki TR, Mirbaha H, Eades WC, Belaygorod L, Cairns NJ, Holtzman DM, Diamond MI, et al (2014). Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci U S A, 111(41), E4376-E4385. Abstract. Author URL.
Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, et al (2014). Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature, 505(7484), 550-554. Abstract.
Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, et al (2014). TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathol, 127(3), 407-418. Abstract. Author URL.
Esparza TJ, Zhao H, Cirrito JR, Cairns NJ, Bateman RJ, Holtzman DM, Brody DL (2013). Amyloid-β oligomerization in Alzheimer dementia versus high-pathology controls. Ann Neurol, 73(1), 104-119. Abstract. Author URL.
Harms M, Benitez BA, Cairns N, Cooper B, Cooper P, Mayo K, Carrell D, Faber K, Williamson J, Bird T, et al (2013). C9orf72 hexanucleotide repeat expansions in clinical alzheimer disease. JAMA Neurology, 70(6), 736-741. Abstract.
Toledo JB, Cairns NJ, Da X, Chen K, Carter D, Fleisher A, Householder E, Ayutyanont N, Roontiva A, Bauer RJ, et al (2013). Clinical and multimodal biomarker correlates of ADNI neuropathological findings. Acta Neuropathol Commun, 1 Abstract. Author URL.
Monsell SE, Mock C, Roe CM, Ghoshal N, Morris JC, Cairns NJ, Kukull W (2013). Comparison of symptomatic and asymptomatic persons with Alzheimer disease neuropathology. Neurology, 80(23), 2121-2129. Abstract.
Boxer AL, Gold M, Huey E, Gao F-B, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, et al (2013). Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement, 9(2), 176-188. Abstract. Author URL.
Armstrong RA, Hamilton RL, Mackenzie IRA, Hedreen J, Cairns NJ (2013). Laminar distribution of the pathological changes in sporadic frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein of 43 kDa (TDP-43) proteinopathy: a quantitative study using polynomial curve fitting. Neuropathol Appl Neurobiol, 39(4), 335-347. Abstract. Author URL.
Davidson YS, Robinson AC, Hu Q, Mishra M, Baborie A, Jaros E, Perry RH, Cairns NJ, Richardson A, Gerhard A, et al (2013). Nuclear carrier and RNA-binding proteins in frontotemporal lobar degeneration associated with fused in sarcoma (FUS) pathological changes. Neuropathol Appl Neurobiol, 39(2), 157-165. Abstract. Author URL.
Vos SJ, Xiong C, Visser PJ, Jasielec MS, Hassenstab J, Grant EA, Cairns NJ, Morris JC, Holtzman DM, Fagan AM, et al (2013). Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study. Lancet Neurol, 12(10), 957-965. Abstract. Author URL.
Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, et al (2013). Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial (vol 169, pg 737, 2013). REVUE NEUROLOGIQUE, 169(12), 1018-1018. Author URL.
Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, et al (2013). Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Rev Neurol (Paris), 169(10), 737-743. Abstract. Author URL.
Campbell MC, Markham J, Flores H, Hartlein JM, Goate AM, Cairns NJ, Videen TO, Perlmutter JS (2013). Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases. Neurology, 81(6), 520-527. Abstract. Author URL.
Benzinger TLS, Blazey T, Jack CR, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, et al (2013). Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proc Natl Acad Sci U S A, 110(47), E4502-E4509. Abstract. Author URL.
Sun J, Cairns NJ, Perlmutter JS, Mach RH, Xu J (2013). Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience, 248, 112-126. Abstract. Author URL.
Armstrong RA, Cairns NJ (2013). Spatial patterns of the tau pathology in progressive supranuclear palsy. Neurol Sci, 34(3), 337-344. Abstract. Author URL.
Cheng H, Wang M, Li J-L, Cairns NJ, Han X (2013). Specific changes of sulfatide levels in individuals with pre-clinical Alzheimer's disease: an early event in disease pathogenesis. J Neurochem, 127(6), 733-738. Abstract. Author URL.
Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, et al (2013). The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement, 9(5), e111-e194. Abstract. Author URL.
Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao F-B, Burton EA, Chow T, Kao A, et al (2013). The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement, 9(2), 189-198. Abstract. Author URL.
Cash DM, Ridgway GR, Liang Y, Ryan NS, Kinnunen KM, Yeatman T, Malone IB, Benzinger TLS, Jack CR, Thompson PM, et al (2013). The pattern of atrophy in familial Alzheimer disease: volumetric MRI results from the DIAN study. Neurology, 81(16), 1425-1433. Abstract. Author URL.
Klingstedt T, Shirani H, Åslund KOA, Cairns NJ, Sigurdson CJ, Goedert M, Nilsson KPR (2013). The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates. Chemistry, 19(31), 10179-10192. Abstract. Author URL.
Ghoshal N, Cairns NJ (2013). Unravelling the mysteries of frontotemporal dementia. Mo Med, 110(5), 411-416. Abstract. Author URL.
Armstrong RA, Carter D, Cairns NJ (2012). A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP). Neuropathol Appl Neurobiol, 38(1), 25-38. Abstract. Author URL.
Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, et al (2012). Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proc Natl Acad Sci U S A, 109(10), 3985-3990. Abstract. Author URL.
Bateman RJ, Xiong C, Benzinger TLS, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, et al (2012). Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med, 367(9), 795-804. Abstract. Author URL.
Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, et al (2012). Common genetic variants in the <i>CLDN2</i> and <i>PRSS1-PRSS2</i> loci alter risk for alcohol-related and sporadic pancreatitis. NATURE GENETICS, 44(12), 1349-1354. Author URL.
Ghoshal N, Dearborn JT, Wozniak DF, Cairns NJ (2012). Core features of frontotemporal dementia recapitulated in progranulin knockout mice. Neurobiol Dis, 45(1), 395-408. Abstract. Author URL.
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, et al (2012). Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol, 71(5), 362-381. Abstract. Author URL.
Morris JC, Aisen PS, Bateman RJ, Benzinger TLS, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, et al (2012). Developing an international network for Alzheimer research: the Dominantly Inherited Alzheimer Network. Clin Investig (Lond), 2(10), 975-984. Abstract. Author URL.
Armstrong RA, Cairns NJ (2012). Different molecular pathologies result in similar spatial patterns of cellular inclusions in neurodegenerative disease: a comparative study of eight disorders. J Neural Transm (Vienna), 119(12), 1551-1560. Abstract. Author URL.
Sun J, Xu J, Cairns NJ, Perlmutter JS, Mach RH (2012). Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain. PLoS One, 7(11). Abstract. Author URL.
Coppola G, Chinnathambi S, Lee JJY, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, et al (2012). Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics, 21(15), 3500-3512. Abstract.
Halliday G, Bigio EH, Cairns NJ, Neumann M, Mackenzie IRA, Mann DMA (2012). Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects. Acta Neuropathol, 124(3), 373-382. Abstract. Author URL.
Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, et al (2012). National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement, 8(1), 1-13. Abstract. Author URL.
Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, et al (2012). National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol, 123(1), 1-11. Abstract. Author URL.
Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, et al (2012). Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology, 79(3), 221-228. Abstract. Author URL.
Kotzbauer PT, Cairns NJ, Campbell MC, Willis AW, Racette BA, Tabbal SD, Perlmutter JS (2012). Pathologic accumulation of α-synuclein and Aβ in Parkinson disease patients with dementia. Arch Neurol, 69(10), 1326-1331. Abstract. Author URL.
Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Green RC, Harvey D, Jack CR, Jagust W, Liu E, et al (2012). The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception. Alzheimers Dement, 8(1 Suppl), S1-68. Abstract. Author URL.
McDonald JM, Cairns NJ, Taylor-Reinwald L, Holtzman D, Walsh DM (2012). The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain. Brain Res, 1450, 138-147. Abstract. Author URL.
Armstrong RA, Cairns NJ (2011). A morphometric study of the spatial patterns of TDP-43 immunoreactive neuronal inclusions in frontotemporal lobar degeneration (FTLD) with progranulin (GRN) mutation. Histol Histopathol, 26(2), 185-190. Abstract. Author URL.
Naj AC, Jun G, Beecham GW, Wang L-S, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, et al (2011). Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet, 43(5), 436-441. Abstract. Author URL.
Mackenzie IRA, Munoz DG, Kusaka H, Yokota O, Ishihara K, Roeber S, Kretzschmar HA, Cairns NJ, Neumann M (2011). Distinct pathological subtypes of FTLD-FUS. Acta Neuropathol, 121(2), 207-218. Abstract. Author URL.
Page T, Gitcho MA, Mosaheb S, Carter D, Chakraverty S, Perry RH, Bigio EH, Gearing M, Ferrer I, Goate AM, et al (2011). FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy. J Mol Neurosci, 45(3), 409-421. Abstract. Author URL.
Chen-Plotkin AS, Martinez-Lage M, Sleiman PMA, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, et al (2011). Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Arch Neurol, 68(4), 488-497. Abstract. Author URL.
Dequen F, Cairns NJ, Bigio EH, Julien J-P (2011). Gigaxonin mutation analysis in patients with NIFID. Neurobiol Aging, 32(8), 1528-1529. Abstract. Author URL.
Rademakers R, Baker M, Nicholson AM, Rutherford NJ, Finch N, Soto-Ortolaza A, Lash J, Wider C, Wojtas A, DeJesus-Hernandez M, et al (2011). Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nat Genet, 44(2), 200-205. Abstract. Author URL.
Mackenzie IRA, Neumann M, Cairns NJ, Munoz DG, Isaacs AM (2011). Novel types of frontotemporal lobar degeneration: beyond tau and TDP-43. J Mol Neurosci, 45(3), 402-408. Abstract. Author URL.
Zhu L, Cairns NJ, Tabbal SD, Racette BA (2011). Pregnancy in multiple system atrophy: a case report. J Med Case Rep, 5 Abstract. Author URL.
Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mackenzie IRA, Perry RH, Skullerud K, Yokoo H, Cairns NJ, et al (2011). Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID). J Neural Transm (Vienna), 118(11), 1651-1657. Abstract. Author URL.
Armstrong RA, Cairns NJ (2011). Spatial patterns of TDP-43 neuronal cytoplasmic inclusions (NCI) in fifteen cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP). Neurol Sci, 32(4), 653-659. Abstract. Author URL.
Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mackenzie IRA, Perry RH, Skullerud K, Yokoo H, Cairns NJ, et al (2011). The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease. Acta Neuropathol, 121(2), 219-228. Abstract. Author URL.
Tarawneh R, D'Angelo G, Macy E, Xiong C, Carter D, Cairns NJ, Fagan AM, Head D, Mintun MA, Ladenson JH, et al (2011). Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease. Ann Neurol, 70(2), 274-285. Abstract. Author URL.
Foster ER, Campbell MC, Burack MA, Hartlein J, Flores HP, Cairns NJ, Hershey T, Perlmutter JS (2010). Amyloid imaging of Lewy body-associated disorders. Mov Disord, 25(15), 2516-2523. Abstract. Author URL.
Armstrong RA, Cairns NJ (2010). Analysis of beta-amyloid (Abeta) deposition in the temporal lobe in Alzheimer's disease using Fourier (spectral) analysis. Neuropathol Appl Neurobiol, 36(3), 248-257. Abstract. Author URL.
Cairns NJ, Taylor-Reinwald L, Morris JC, Alzheimer's Disease Neuroimaging Initiative (2010). Autopsy consent, brain collection, and standardized neuropathologic assessment of ADNI participants: the essential role of the neuropathology core. Alzheimers Dement, 6(3), 274-279. Abstract. Author URL.
Van Deerlin VM, Sleiman PMA, Martinez-Lage M, Chen-Plotkin A, Wang L-S, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, et al (2010). Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet, 42(3), 234-239. Abstract. Author URL.
Cairns NJ, Ghoshal N (2010). FUS: a new actor on the frontotemporal lobar degeneration stage. Neurology, 74(5), 354-356. Author URL.
Burack MA, Hartlein J, Flores HP, Taylor-Reinwald L, Perlmutter JS, Cairns NJ (2010). In vivo amyloid imaging in autopsy-confirmed Parkinson disease with dementia. Neurology, 74(1), 77-84. Abstract. Author URL.
Armstrong RA, Ellis W, Hamilton RL, Mackenzie IRA, Hedreen J, Gearing M, Montine T, Vonsattel J-P, Head E, Lieberman AP, et al (2010). Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. J Neural Transm (Vienna), 117(2), 227-239. Abstract. Author URL.
Mackenzie IRA, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, et al (2010). Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol, 119(1), 1-4. Author URL.
Cairns NJ, Perrin RJ, Schmidt RE, Gru A, Green KG, Carter D, Taylor-Reinwald L, Morris JC, Gitcho MA, Baloh RH, et al (2010). TDP-43 proteinopathy in familial motor neurone disease with TARDBP A315T mutation: a case report. Neuropathol Appl Neurobiol, 36(7), 673-679. Author URL.
Weiner MW, Aisen PS, Jack CR, Jagust WJ, Trojanowski JQ, Shaw L, Saykin AJ, Morris JC, Cairns N, Beckett LA, et al (2010). The Alzheimer's Disease Neuroimaging Initiative: Progress report and future plans. Alzheimer's and Dementia, 6(3). Abstract.
Cairns NJ, Morris JC (2010). The Challenge and Public Health Implications of Alzheimer Overdiagnosis in the Oldest Old <i>Reply</i>. ARCHIVES OF NEUROLOGY, 67(7), 900-901. Author URL.
Zou W-Q, Puoti G, Xiao X, Yuan J, Qing L, Cali I, Shimoji M, Langeveld JPM, Castellani R, Notari S, et al (2010). Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein. Ann Neurol, 68(2), 162-172. Abstract. Author URL.
Craig-Schapiro R, Perrin RJ, Roe CM, Xiong C, Carter D, Cairns NJ, Mintun MA, Peskind ER, Li G, Galasko DR, et al (2010). YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease. Biol Psychiatry, 68(10), 903-912. Abstract. Author URL.
Armstrong RA, Ironside JW, Lantos PL, Cairns NJ (2009). A quantitative study of the pathological changes in the cerebellum in 15 cases of variant Creutzfeldt-Jakob disease (vCJD). Neuropathol Appl Neurobiol, 35(1), 36-45. Abstract. Author URL.
Cairns NJ, Ikonomovic MD, Benzinger T, Storandt M, Fagan AM, Shah AR, Reinwald LT, Carter D, Felton A, Holtzman DM, et al (2009). Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report. Arch Neurol, 66(12), 1557-1562. Abstract. Author URL.
Armstrong RA, Cairns NJ (2009). Clustering and spatial correlations of the neuronal cytoplasmic inclusions, astrocytic plaques and ballooned neurons in corticobasal degeneration. J Neural Transm (Vienna), 116(9), 1103-1110. Abstract. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2009). Hippocampal pathology in progressive supranuclear palsy (PSP): a quantitative study of 8 cases. Clin Neuropathol, 28(1), 46-53. Abstract. Author URL.
Armstrong RA, Cairns NJ (2009). Laminar distribution of the pathological changes in frontal and temporal cortex in 8 patients with progressive supranuclear palsy. Clin Neuropathol, 28(5), 350-357. Abstract. Author URL.
Mackenzie IRA, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, et al (2009). Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathol, 117(1), 15-18. Author URL.
Norton JB, Cairns NJ, Chakraverty S, Wang J, Levitch D, Galvin JE, Goate A (2009). Presenilin1 G217R mutation linked to Alzheimer disease with cotton wool plaques. Neurology, 73(6), 480-482. Author URL.
Armstrong RA, Cairns NJ (2009). Size frequency distribution of the beta-amyloid (abeta) deposits in dementia with Lewy bodies with associated Alzheimer's disease pathology. Neurol Sci, 30(6), 471-477. Abstract. Author URL.
Gitcho MA, Bigio EH, Mishra M, Johnson N, Weintraub S, Mesulam M, Rademakers R, Chakraverty S, Cruchaga C, Morris JC, et al (2009). TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy. Acta Neuropathol, 118(5), 633-645. Abstract. Author URL.
Wegorzewska I, Bell S, Cairns NJ, Miller TM, Baloh RH (2009). TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc Natl Acad Sci U S A, 106(44), 18809-18814. Abstract. Author URL.
Rollinson S, Rizzu P, Sikkink S, Baker M, Halliwell N, Snowden J, Traynor BJ, Ruano D, Cairns N, Rohrer JD, et al (2009). Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration. Neurobiology of Aging, 30(4), 656-665. Abstract.
Gitcho MA, Strider J, Carter D, Taylor-Reinwald L, Forman MS, Goate AM, Cairns NJ (2009). VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death. J Biol Chem, 284(18), 12384-12398. Abstract. Author URL.
Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CLIII, Bigio EH, Caselli R, et al (2008). <i>TDP-43</i> A315T mutation in familial motor neuron disease. ANNALS OF NEUROLOGY, 63(4), 535-538. Author URL.
Liscic RM, Grinberg LT, Zidar J, Gitcho MA, Cairns NJ (2008). ALS and FTLD: two faces of TDP-43 proteinopathy. EUROPEAN JOURNAL OF NEUROLOGY, 15(8), 772-780. Author URL.
Li Y, Grupe A, Rowland C, Holmans P, Segurado R, Abraham R, Jones L, Catanese J, Ross D, Mayo K, et al (2008). Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Hum Mol Genet, 17(5), 759-767. Abstract. Author URL.
Thorpe JR, Tang H, Atherton J, Cairns NJ (2008). Fine structural analysis of the neuronal inclusions of frontotemporal lobar degeneration with TDP-43 proteinopathy. J Neural Transm (Vienna), 115(12), 1661-1671. Abstract. Author URL.
Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JSK, Norton J, Levitch D, Bigio EH, et al (2008). Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. HUMAN MUTATION, 29(4), 512-521. Author URL.
Cairns NJ (2008). Neuronal intermediate filament inclusion disease. Handb Clin Neurol, 89, 443-448. Author URL.
Wippold FJ, Cairns N, Vo K, Holtzman DM, Morris JC (2008). Neuropathology for the neuroradiologist: Plaques and tangles. American Journal of Neuroradiology, 29(1), 18-22. Abstract.
Hatanpaa KJ, Bigio EH, Cairns NJ, Womack KB, Weintraub S, Morris JC, Foong C, Xiao G, Hladik C, Mantanona TY, et al (2008). TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a Midwest-Southwest Consortium for FTLD study. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 67(4), 271-279. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2008). What determines the molecular composition of abnormal protein aggregates in neurodegenerative disease?. NEUROPATHOLOGY, 28(4), 351-365. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2007). A quantitative study of the pathological changes in white matter in multiple system atrophy. NEUROPATHOLOGY, 27(3), 221-227. Author URL.
Liscic RM, Storandt M, Cairns NJ, Morris JC (2007). Clinical and psychometric distinction of frontotemporal and Alzheimer dementias. ARCHIVES OF NEUROLOGY, 64(4), 535-540. Author URL.
Hu Y, Kauwe JSK, Gross J, Cairns NJ, Goate AM, Fagan AM, Townsend RR, Holtzman DM (2007). Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease. PROTEOMICS CLINICAL APPLICATIONS, 1(11), 1373-1384. Author URL.
Cairns NJ, Bigio EH, Mackenzie IRA, Neumann M, Lee VM-Y, Hatanpaa KJ, White CLIII, Schneider JA, Grinberg LT, Halliday G, et al (2007). Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. ACTA NEUROPATHOLOGICA, 114(1), 5-22. Author URL.
Behrens MI, Mukherjee O, Tu P-H, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor-Reinwald L, Gitcho M, Norton JB, et al (2007). Neuropathologic heterogeneity in HDDD1:: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and <i>progranulin</i> mutation. ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 21(1), 1-7. Author URL.
Mackenzie IRA, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, et al (2007). Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with <i>SOD1</i> mutations. ANNALS OF NEUROLOGY, 61(5), 427-434. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2007). Progressive supranuclear palsy (PSP): a quantitative study of the pathological changes in cortical and subcortical regions of eight cases. JOURNAL OF NEURAL TRANSMISSION, 114(12), 1569-1577. Author URL.
Armstrong RA, Cairns NJ (2007). Spatial patterns of the pathological changes in neuronal intermediate filament inclusion disease (NIFID):: an α-internexin immunohistochemical study. JOURNAL OF NEURAL TRANSMISSION, 114(4), 451-456. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2007). Spatial topography of the neurofibrillary tangles in cortical and subcortical regions in progressive supranuclear palsy. PARKINSONISM & RELATED DISORDERS, 13(1), 50-54. Author URL.
Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CLIII, Schneider JA, Kretzschmar HA, et al (2007). TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. AMERICAN JOURNAL OF PATHOLOGY, 171(1), 227-240. Author URL.
Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS, et al (2007). TDP-43 in the ubiquitin pathology of frontotemporal dementia with <i>VCP</i> gene mutations. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 66(2), 152-157. Author URL.
Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chio A, et al (2006). Analysis of <i>IFT74</i> as a candidate gene for chromosome 9p-linked ALS-FTD. BMC NEUROLOGY, 6 Author URL.
Lumbreras M, Baamonde C, Martínez-Cué C, Lubec G, Cairns N, Sallés J, Dierssen M, Flórez J (2006). Brain G protein-dependent signaling pathways in Down syndrome and Alzheimer's disease. Amino Acids, 31(4), 449-456. Abstract.
Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JSK, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, et al (2006). HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. ANNALS OF NEUROLOGY, 60(3), 314-322. Author URL.
Armstrong RA, Cairns NJ (2006). Laminar degeneration of the frontal and temporal cortex in neuronal intermediate filament inclusion disease (NIFID): a study using a-internexin immunohistochemistry. CLINICAL NEUROPATHOLOGY, 25(5), 209-215. Author URL.
Cairns NJ, Bigio EH, Mackenzie IR (2006). Letter to the editor. J Neuropathol Exp Neurol, 65(1). Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2006). Multiple system atrophy (MSA): Topographic distribution of the α-synuclein-associated pathological changes. Parkinsonism and Related Disorders, 12(6), 356-362. Abstract.
Armstrong RA, Cairns NJ, Lantos PL (2006). Multiple system atrophy (MSA):: Topographic distribution of the α-synuclein-associated pathological changes. PARKINSONISM & RELATED DISORDERS, 12(6), 356-362. Author URL.
Momeni P, Cairns NJ, Perry RH, Bigio EH, Gearing M, Singleton AB, Hardy J (2006). Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID). Neurobiol Aging, 27(5), 778.e1-778.e6. Abstract. Author URL.
Armstrong RA, Kerty E, Skullerud K, Cairns NJ (2006). Neuropathological changes in ten cases of neuronal intermediate filament inclusion disease (NIFID):: a study using α-internexin immunohistochemistry and principal components analysis (PCA). JOURNAL OF NEURAL TRANSMISSION, 113(9), 1207-1215. Author URL.
Forman MS, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri BS, Karlawish JH, Pestronk A, Smith TW, et al (2006). Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol, 65(6), 571-581. Abstract. Author URL.
Hashemzadeh-Bonehi L, Phillips RG, Cairns NJ, Mosaheb S, Thorpe JR (2006). Pin1 protein associates with neuronal lipofuscin: Potential consequences in age-related neurodegeneration. EXPERIMENTAL NEUROLOGY, 199(2), 328-338. Author URL.
Armstrong RA, Cairns NJ, Ironside JW (2006). Size frequency distributions of the florid prion protein aggregates in variant Creutzfeldt-Jakob disease follow a power-law function. NEUROLOGICAL SCIENCES, 27(2), 104-109. Author URL.
Armstrong RA, Cairns NJ (2006). Topography of <i>α</i>-internexin-positive neuronal aggregates in 10 patients with neuronal intermediate filament inclusion disease. EUROPEAN JOURNAL OF NEUROLOGY, 13(5), 528-532. Author URL.
Sudo S, Shiozawa M, Cairns NJ, Wada Y (2005). Aberrant accentuation of neurofibrillary degeneration in the hippocampus of Alzheimer's disease with amyloid precursor protein 717 and presenilin-1 gene mutations. J Neurol Sci, 234(1-2), 55-65. Abstract. Author URL.
Cook LJ, Ho LW, Wang L, Terrenoire E, Brayne C, Evans JG, Xuereb J, Cairns NJ, Turic D, Hollingworth P, et al (2005). Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. Am J Med Genet B Neuropsychiatr Genet, 132B(1), 5-8. Abstract. Author URL.
Jamieson SE, White JK, Howson JMM, Pask R, Smith AN, Brayne C, Evans JG, Xuereb J, Cairns NJ, Rubinsztein DC, et al (2005). Candidate gene association study of solute carrier family 11a members 1 (SLC11A1) and 2 (SLC11A2) genes in Alzheimer's disease. Neurosci Lett, 374(2), 124-128. Abstract. Author URL.
Rezaie P, Pontikis CC, Hudson L, Cairns NJ, Lantos PL (2005). Expression of cellular prion protein in the frontal and occipital lobe in Alzheimer's disease, diffuse Lewy body disease, and in normal brain: an immunohistochemical study. J Histochem Cytochem, 53(8), 929-940. Abstract. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2005). Multiple system atrophy: laminar distribution of the pathological changes in frontal and temporal neocortex--a study in ten patients. Clin Neuropathol, 24(5), 230-235. Abstract. Author URL.
Mosaheb S, Thorpe JR, Hashemzadeh-Bonehi L, Bigio EH, Gearing M, Cairns NJ (2005). Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion disease. Acta Neuropathol, 110(4), 360-368. Abstract. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2005). Overlap between neurodegenerative disorders. Neuropathology, 25(2), 111-124. Abstract. Author URL.
Blomqvist ME-L, Chalmers K, Andreasen N, Bogdanovic N, Wilcock GK, Cairns NJ, Feuk L, Brookes AJ, Love S, Blennow K, et al (2005). Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain. Neurobiol Aging, 26(6), 795-802. Abstract. Author URL.
Armstrong RA, Cairns NJ, Ironside JW, Lantos PL (2005). Size frequency distribution of prion protein (PrP) aggregates in variant Creutzfeldt-Jakob disease (vCJD). J Neural Transm (Vienna), 112(11), 1565-1573. Abstract. Author URL.
Cairns NJ, Armstrong RA (2005). Spatial correlations between the neuronal inclusions, swollen achromatic neurons, and glial cells in neuronal intermediate filament inclusion disease (NIFID). J Neural Transm (Vienna), 112(4), 473-480. Abstract. Author URL.
Cairns NJ, Armstrong RA (2005). Spatial patterns of the pathological changes in the temporal lobe of patients with neuronal intermediate filament inclusion disease. Neuropathology, 25(4), 298-303. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2004). A quantitative study of the pathological changes in ten patients with multiple system atrophy (MSA). J Neural Transm (Vienna), 111(4), 485-495. Abstract. Author URL.
Preece P, Virley DJ, Costandi M, Coombes R, Moss SJ, Mudge AW, Jazin E, Cairns NJ (2004). Amyloid precursor protein mRNA levels in Alzheimer's disease brain. Brain Res Mol Brain Res, 122(1), 1-9. Abstract. Author URL.
Cook LJ, Ho LW, Taylor AE, Brayne C, Evans JG, Xuereb J, Cairns NJ, Pritchard A, Lemmon H, Mann D, et al (2004). Candidate gene association studies of the α4 (CHRNA4) and β2 (CHRNB2) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease. NEUROSCIENCE LETTERS, 358(2), 142-146. Author URL.
Cairns NJ, Grossman M, Arnold SE, Burn DJ, Jaros E, Perry RH, Duyckaerts C, Stankoff B, Pillon B, Skullerud K, et al (2004). Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease. Neurology, 63(8), 1376-1384. Abstract. Author URL.
Kehoe PG, Katzov H, Andreasen N, Gatz M, Wilcock GK, Cairns NJ, Palmgren J, de Faire U, Brookes AJ, Pedersen NL, et al (2004). Common variants of ACE contribute to variable age-at-onset of Alzheimer's disease. Hum Genet, 114(5), 478-483. Abstract. Author URL.
Katzov H, Chalmers K, Palmgren J, Andreasen N, Johansson B, Cairns NJ, Gatz M, Wilcock GK, Love S, Pedersen NL, et al (2004). Genetic variants of <i>ABCA1</i> modify Alzheimer disease risk and quantitative traits related to β-amyloid metabolism. HUMAN MUTATION, 23(4), 358-367. Author URL.
Schuessel K, Leutner S, Cairns NJ, Müller WE, Eckert A (2004). Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer's disease brain. J Neural Transm (Vienna), 111(9), 1167-1182. Abstract. Author URL.
Cairns NJ, Jaros E, Perry RH, Amstrong RA (2004). Laminar distribution of neurofilament inclusions and swollen achromatic neurons in neurofilament inclusion disease (NID). NEUROSCIENCE RESEARCH COMMUNICATIONS, 34(2), 104-111. Author URL.
Cairns NJ, Armstrong RA (2004). Quantification of the pathological changes in the temporal lobe of patients with a novel neurofilamentopathy: neurofilament inclusion disease (NID). Clin Neuropathol, 23(3), 107-112. Abstract. Author URL.
Cairns N (2004). Separate course for psychiatric nursing needed. Nursing New Zealand (Wellington, N.Z. : 1995), 10(1).
Thorpe JR, Mosaheb S, Hashemzadeh-Bonehi L, Cairns NJ, Kay JE, Morley SJ, Rulten SL (2004). Shortfalls in the peptidyl-prolyl cis-trans isomerase protein Pin1 in neurons are associated with frontotemporal dementias. Neurobiol Dis, 17(2), 237-249. Abstract. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2004). Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophy. Mov Disord, 19(1), 109-112. Abstract. Author URL.
Cairns NJ, Jaros E, Perry RH, Armstrong RA (2004). Temporal lobe pathology of human patients with neurofilament inclusion disease. Neurosci Lett, 354(3), 245-247. Abstract. Author URL.
Cairns NJ, Lee VM-Y, Trojanowski JQ (2004). The cytoskeleton in neurodegenerative diseases. J Pathol, 204(4), 438-449. Abstract. Author URL.
Cairns NJ, Zhukareva V, Uryu K, Zhang B, Bigio E, Mackenzie IRA, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, et al (2004). alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. Am J Pathol, 164(6), 2153-2161. Abstract. Author URL.
Cairns NJ, Uryu K, Bigio EH, Mackenzie IRA, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, et al (2004). α-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. ACTA NEUROPATHOLOGICA, 108(3), 213-223. Author URL.
Cairns NJ, Uryu K, Bigio EH, Mackenzie IRA, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, et al (2004). α-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Acta Neuropathologica, 108(3), 213-223. Abstract.
Armstrong RA, Lantos PL, Cairns NJ (2003). A quantitative study of the pathological changes in cortical neurons in sporadic Creutzfeldt-Jakob disease. Neuropathology, 23(3), 181-187. Abstract. Author URL.
Krapfenbauer K, Engidawork E, Cairns N, Fountoulakis M, Lubec G (2003). Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders. Brain Research, 967(1-2), 152-160. Abstract.
Preece P, Virley DJ, Costandi M, Coombes R, Moss SJ, Mudge AW, Jazin E, Cairns NJ (2003). An optimistic view for quantifying mRNA in post-mortem human brain. MOLECULAR BRAIN RESEARCH, 116(1-2), 7-16. Author URL.
Preece P, Virley DJ, Costandi M, Coombes R, Moss SJ, Mudge AW, Jazin E, Cairns NJ (2003). Beta-secretase (BACE) and GSK-3 mRNA levels in Alzheimer's disease. Brain Res Mol Brain Res, 116(1-2), 155-158. Abstract. Author URL.
Cairns NJ, Armstrong RA (2003). Clustering of neuronal inclusions in "dementia with neurofilament inclusions". Acta Neuropathol, 106(2), 125-128. Abstract. Author URL.
Pollak D, Cairns N, Lubec G (2003). Cytoskeleton derangement in brain of patients with Down Syndrome, Alzheimer's disease and Pick's disease. Journal of Neural Transmission, Supplement(67), 149-158. Abstract.
Armstrong RA, Lantos PL, Ironside JW, Cairns NJ (2003). Differences in the density and spatial distribution of florid and diffuse plaques in variant Creutzfeldt-Jakob disease (vCJD). Clin Neuropathol, 22(5), 209-214. Abstract. Author URL.
Armstrong RA, Cairns NJ, Ironside JW, Lantos PL (2003). Does the neuropathology of human patients with variant Creutzfeldt-Jakob disease reflect haematogenous spread of the disease?. Neurosci Lett, 348(1), 37-40. Abstract. Author URL.
Armstrong RA, Cairns NJ, Ironside JW, Lantos PL (2003). Florid prion protein (PrP) plaques in patients with variant Creutzfeldt-Jakob disease (vCJD) are spatially related to blood vessels. NEUROSCIENCE RESEARCH COMMUNICATIONS, 32(1), 29-36. Author URL.
Shiozawa M, Fukutani Y, Arai N, Cairns NJ, Mizutani T, Isaki K, Lantos PL, Wada Y (2003). Glyceraldehyde 3-phosphate dehydrogenase and endothelin-1 immunoreactivity is associated with cerebral white matter damage in dentatorubral-pallidoluysian atrophy. Neuropathology, 23(1), 36-43. Abstract. Author URL.
Kehoe PG, Katzov H, Feuk L, Bennet AM, Johansson B, Wiman B, de Faire U, Cairns NJ, Wilcock GK, Brookes AJ, et al (2003). Haplotypes extending across ACE are associated with Alzheimer's disease. Hum Mol Genet, 12(8), 859-867. Abstract. Author URL.
Greber-Platzer S, Fleischmann C, Nussbaumer C, Cairns N, Lubec G (2003). Increased RNA levels of the 25 kDa synaptosomal associated protein in brain samples of adult patients with Down Syndrome. Neuroscience Letters, 336(2), 77-80. Abstract.
Cairns NJ, Brännström T, Khan MN, Rossor MN, Lantos PL (2003). Neuronal loss in familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions. Exp Neurol, 181(2), 319-326. Abstract. Author URL.
Kovács T, Papp MI, Cairns NJ, Khan MN, Lantos PL (2003). Olfactory bulb in multiple system atrophy. Mov Disord, 18(8), 938-942. Abstract. Author URL.
Cairns NJ, Perry RH, Jaros E, Burn D, McKeith IG, Lowe JS, Holton J, Rossor MN, Skullerud K, Duyckaerts C, et al (2003). Patients with a novel neurofilamentopathy: dementia with neurofilament inclusions. Neurosci Lett, 341(3), 177-180. Abstract. Author URL.
Preece P, Cairns NJ (2003). Quantifying mRNA in postmortem human brain: influence of gender, age at death, postmortem interval, brain pH, agonal state and inter-lobe mRNA variance. Brain Res Mol Brain Res, 118(1-2), 60-71. Abstract. Author URL.
Teufel M, Saudek V, Ledig J-P, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, et al (2003). Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. J Biol Chem, 278(8), 6521-6531. Abstract. Author URL.
Armstrong RA, Lantos PL, Ironside JW, Cairns NJ (2003). Spatial correlation between the vacuolation, prion protein, deposition and surviving neurons in patients with Creutzfeldt-Jakob disease (vCJD). J Neural Transm (Vienna), 110(11), 1303-1311. Abstract. Author URL.
Armstrong RA, Cairns NJ (2003). Spatial patterns of the pathological changes in the cerebellar cortex in sporadic Creutzfeldt-Jakob disease (sCJD). Folia Neuropathol, 41(4), 183-189. Abstract. Author URL.
Culpan D, MacGowan SH, Ford JM, Nicoll JAR, Griffin WS, Dewar D, Cairns NJ, Hughes A, Kehoe PG, Wilcock GK, et al (2003). Tumour necrosis factor-alpha gene polymorphisms and Alzheimer's disease. Neurosci Lett, 350(1), 61-65. Abstract. Author URL.
Ballard C, Johnson M, Piggott M, Perry R, O'Brien J, Rowan E, Perry E, Lantos P, Cairns N, Holmes C, et al (2002). A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodies. J Affect Disord, 69(1-3), 219-223. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2002). Are pathological lesions in neurodegenerative disorders the cause or the effect of the degeneration?. Neuropathology, 22(3), 133-146. Abstract. Author URL.
Kim SH, Krapfenbauer K, Cheon MS, Fountoulakis M, Cairns NJ, Lubec G (2002). Human brain cytosolic histamine-N-methyltransferase is decreased in Down syndrome and increased in Pick's disease. Neurosci Lett, 321(3), 169-172. Abstract. Author URL.
Kim SH, Fountoulakis M, Cairns NJ, Lubec G (2002). Human brain nucleoside diphosphate kinase activity is decreased in Alzheimer's disease and Down syndrome. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 296(4), 970-975. Author URL.
Emilsson L, Saetre P, Balciuniene J, Castensson A, Cairns N, Jazin EE (2002). Increased monoamine oxidase messenger RNA expression levels in frontal cortex of Alzheimer's disease patients. Neuroscience Letters, 326(1), 56-60. Abstract.
Armstrong RA, Cairns NJ, Ironside JW, Lantos PL (2002). Laminar distribution of the pathological changes in the cerebral cortex in variant Creutzfeldt-Jakob disease (vCJD). Folia Neuropathol, 40(4), 165-171. Abstract. Author URL.
Lantos PL, Cairns NJ, Khan MN, King A, Revesz T, Janssen JC, Morris H, Rossor MN (2002). Neuropathologic variation in frontotemporal dementia due to the intronic tau 10(+16) mutation. Neurology, 58(8), 1169-1175. Abstract. Author URL.
Cook L, Brayne CE, Easton D, Evans JG, Xuereb J, Cairns NJ, Rubinsztein DC (2002). No evidence for an association between Saitohin Q7R polymorphism and Alzheimer's disease. Ann Neurol, 52(5), 690-691. Author URL.
Yoo BC, Krapfenbauer K, Cairns N, Belay G, Bajo M, Lubec G (2002). Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease. Neuroscience Letters, 334(3), 196-200. Abstract.
Armstrong RA, Cairns NJ, Ironside JW, Lantos PL (2002). Quantification of vacuolation ("spongiform change"), surviving neurones and prion protein deposition in eleven cases of variant Creutzfeldt-Jakob disease. Neuropathol Appl Neurobiol, 28(2), 129-135. Abstract. Author URL.
Armstrong RA, Cairns NJ, Ironside JW, Lantos PL (2002). Quantitative variations in the pathology of 11 cases of variant Creutzfeldt-Jakob disease (vCJD). Pathophysiology, 8(4), 235-241. Abstract. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2002). Spatial patterns of the vacuolation in subcortical white matter in sporadic Creutzfeldt-Jakob disease (sCJD). Clin Neuropathol, 21(6), 284-288. Abstract. Author URL.
Valerio A, Ferrario M, Paterlini M, Liberini P, Moretto G, Cairns NJ, Pizzi M, Spano P (2002). Spinal cord mGlu1a receptors: possible target for amyotrophic lateral sclerosis therapy. Pharmacol Biochem Behav, 73(2), 447-454. Abstract. Author URL.
Bond BC, Virley DJ, Cairns NJ, Hunter AJ, Moore GBT, Moss SJ, Mudge AW, Walsh FS, Jazin E, Preece P, et al (2002). The quantification of gene expression in an animal model of brain ischaemia using TaqMan real-time RT-PCR. Brain Res Mol Brain Res, 106(1-2), 101-116. Abstract. Author URL.
Armstrong RA, Cairns NJ, Ironside JW, Lantos PL (2002). The spatial pattern of the vacuolation ('spongiform change') in the cerebral cortex in variant Creutzfeldt-Jakob disease (vCJD). NEUROSCIENCE RESEARCH COMMUNICATIONS, 30(1), 43-50. Author URL.
Armstrong RA, Cairns NJ, Ironside JW, Lantos PL (2002). The spatial patterns of prion protein deposits in cases of variant Creutzfeldt-Jakob disease. Acta Neuropathol, 104(6), 665-669. Abstract. Author URL.
Engidawork E, Gulesserian T, Yoo BC, Cairns N, Lubec G (2001). Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease. Biochemical and Biophysical Research Communications, 281(1), 84-93. Abstract.
Gulesserian T, Engidawork E, Yoo BC, Cairns N, Lubec G (2001). Alteration of caspases and other apoptosis regulatory proteins in Down syndrome. Journal of Neural Transmission, Supplement(61), 163-179. Abstract.
Taylor A, Ezquerra M, Bagri G, Yip A, Goumidi L, Cottel D, Easton D, Evans JG, Xuereb J, Cairns NJ, et al (2001). Alzheimer disease is not associated with polymorphisms in the angiotensinogen and renin genes. Am J Med Genet, 105(8), 761-764. Abstract. Author URL.
Mann DMA, Pickering-Brown SM, Takeuchi A, Iwatsubo T, Arango J, Bird T, Van Broeckhoven C, Brooks W, Brown R, Cairns N, et al (2001). Amyloid angiopathy and variability in amyloid β deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease. American Journal of Pathology, 158(6), 2165-2175. Abstract.
Schuller E, Gulesserian T, Seidl R, Cairns N, Lubec G (2001). Brain t-complex polypeptide 1 (TCP-1) related to its natural substrate β1 tubulin is decreased in Alzheimer's disease. Life Sciences, 69(3), 263-270. Abstract.
Mann DM, Takeuchi A, Sato S, Cairns NJ, Lantos PL, Rossor MN, Haltia M, Kalimo H, Iwatsubo T (2001). Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic beta-amyloid pathology known as 'cotton wool' plaques. Neuropathol Appl Neurobiol, 27(3), 189-196. Abstract. Author URL.
Engidawork E, Gulesserian T, Balic N, Cairns N, Lubec G (2001). Changes in nicotinic acetylcholine receptor subunits expression in brain of patients with Down syndrome and Alzheimer's disease. Journal of Neural Transmission, Supplement(61), 211-222. Abstract.
Yoo BC, Fountoulakis M, Cairns N, Lubec G (2001). Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer's disease and Down syndrome. Electrophoresis, 22(1), 172-179. Abstract.
Armstrong RA, Lantos PL, Cairns NJ (2001). Correlations between the clustering patterns of the pathological changes in sporadic Creutzfeldt-Jakob disease. NEUROSCIENCE RESEARCH COMMUNICATIONS, 29(2), 89-98. Author URL.
Vlkolinský R, Cairns N, Fountoulakis M, Lubec G (2001). Decreased brain levels of 2′,3′-cyclic nucleotide-3′-phosphodiesterase in Down syndrome and Alzheimer's disease. Neurobiology of Aging, 22(4), 547-553. Abstract.
Kim SH, Nairn AC, Cairns N, Lubec G (2001). Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease. Journal of Neural Transmission, Supplement(61), 263-272. Abstract.
Cheon MS, Fountoulakis M, Cairns NJ, Dierssen M, Herkner K, Lubec G (2001). Decreased protein levels of stathmin in adult brains with Down syndrome and Alzheimer's disease. J Neural Transm Suppl(61), 281-288. Abstract. Author URL.
Seidl R, Labudova O, Krapfenbauer K, Henriksson EW, Craft J, Turhani-Schatzmann D, Achsel T, Bidmon B, Pruijn GJM, Cairns N, et al (2001). Deficient brain snRNP70K in patients with Down syndrome. Electrophoresis, 22(1), 43-48. Abstract.
Yoo BC, Kim SH, Cairns N, Fountoulakis M, Lubec G (2001). Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease. Biochemical and Biophysical Research Communications, 280(1), 249-258. Abstract.
Seidl R, Cairns N, Singewald N, Kaehler ST, Lubec G (2001). Differences between GABA levels in Alzheimer's disease and Down syndrome with Alzheimer-like neuropathology. Naunyn-Schmiedeberg's Archives of Pharmacology, 363(2), 139-145. Abstract.
Krapfenbauer K, Yoo BC, Kim SH, Cairns N, Lubec G (2001). Differential display reveals downregulation of the phospholipid transfer protein (PLTP) at the mRNA level in brains of patients with Down syndrome. Life Sciences, 68(18), 2169-2179. Abstract.
Yoo BC, Vlkolinsky R, Engidawork E, Cairns N, Fountoulakis M, Lubec G (2001). Differential expression of molecular chaperones in brain of patients with Down syndrome. Electrophoresis, 22(6), 1233-1241. Abstract.
Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, et al (2001). Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol Aging, 22(3), 367-376. Abstract. Author URL.
Seidl R, Bidmon B, Bajo M, Yoo BC, Lubec G, Cairns N, LaCasse EC (2001). Evidence for apoptosis in the fetal Down syndrome brain. Journal of Child Neurology, 16(6), 438-442. Abstract.
Cheon MS, Bajo M, Gulesserian T, Cairns N, Lubec G (2001). Evidence for the relation of herpes simplex virus type 1 to Down syndrome and Alzheimer's disease. Electrophoresis, 22(3), 445-448. Abstract.
Engidawork E, Gulesserian T, Seidl R, Cairns N, Lubec G (2001). Expression of apoptosis related proteins in brains of patients with Alzheimer's disease. Neuroscience Letters, 303(2), 79-82. Abstract.
Engidawork E, Gulesserian T, Seidl R, Cairns N, Lubec G (2001). Expression of apoptosis related proteins: RAIDD, ZIP kinase, Bim/BOD, p21, Bax, Bcl-2 and NF-κB in brains of patients with Down syndrome. Journal of Neural Transmission, Supplement(61), 181-192. Abstract.
Taylor AE, Yip A, Brayne C, Easton D, Evans JG, Xuereb J, Cairns N, Esiri MM, Rubinsztein DC (2001). Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease. Journal of Medical Genetics, 38(4), 232-233. Abstract.
Balcz B, Kirchner L, Cairns N, Fountoulakis M, Lubec G (2001). Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down Syndrome and Alzheimer's disease. Journal of Neural Transmission, Supplement(61), 193-201. Abstract.
Cairns NJ (2001). Molecular neuropathology of transgenic mouse models of Down syndrome. J Neural Transm Suppl(61), 289-301. Abstract. Author URL.
Bajo M, Yoo BC, Cairns N, Gratzer M, Lubec G (2001). Neurofilament proteins NF-L, NF-M and NF-H in brain of patients with Down syndrome and Alzheimer's disease. Amino Acids, 21(3), 293-301. Abstract.
Kovács T, Cairns NJ, Lantos PL (2001). Olfactory centres in Alzheimer's disease: olfactory bulb is involved in early Braak's stages. Neuroreport, 12(2), 285-288. Abstract. Author URL.
Kim SH, Fountoulakis M, Cairns N, Lubec G (2001). Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down Syndrome. Journal of Neural Transmission, Supplement(61), 223-235. Abstract.
Armstrong RA, Lantos PL, Cairns NJ (2001). Quantification of the pathological changes with laminar depth in the cortex in sporadic Creutzfeldt-Jakob disease. Pathophysiology, 8(2), 99-104. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2001). Quantification of the vacuolation (spongiform change) and prion protein deposition in 11 patients with sporadic Creutzfeldt-Jakob disease. Acta Neuropathol, 102(6), 591-596. Abstract. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2001). Spatial correlations between the vacuolation, prion protein deposits, and surviving neurons in the cerebral cortex in sporadic Creutzfeldt-Jakob disease. Neuropathology, 21(4), 266-271. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2001). Spatial pattern of prion protein deposits in patients with sporadic Creutzfeldt-Jakob disease. Neuropathology, 21(1), 19-24. Abstract. Author URL.
Lambri M, Djurovic V, Kibble M, Cairns N, Al-Sarraj S (2001). Specificity and sensitivity of βAPP in head injury. Clinical Neuropathology, 20(6), 263-271. Abstract.
Gulesserian T, Seidl R, Hardmeier R, Cairns N, Lubec G (2001). Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down Syndrome. Journal of Investigative Medicine, 49(1), 41-46. Abstract.
Yoo BC, Cairns N, Fountoulakis M, Lubec G (2001). Synaptosomal proteins, beta-soluble N-ethylmaleimide-sensitive factor attachment protein (Beta-SNAP), gamma-SNAP and synaptotagmin I in brain of patients with Down syndrome and Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 12(3), 219-225. Abstract.
Murphy T, Yip A, Brayne C, Easton D, Evans JG, Xuereb J, Cairns N, Esiri MM, Rubinsztein DC (2001). The BACE gene: Genomic structure and candidate gene study in late-onset Alzheimer's disease. NeuroReport, 12(3), 631-634. Abstract.
Seidl R, Cairns N, Lubec G (2001). The brain in Down syndrome. Journal of Neural Transmission, Supplement(61), 247-261. Abstract.
Kim SH, Vlkolinsky R, Cairns N, Fountoulakis M, Lubec G (2001). The reduction of NADH - Ubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease. Life Sciences, 68(24), 2741-2750. Abstract.
Armstrong RA, Lantos PL, Cairns NJ (2001). The spatial patterns of pathological brain lesions in 12 patients with corticobasal degeneration. Pathophysiology, 8(1), 47-53. Abstract. Author URL.
Armstrong RA, Lantos PL, Cairns NJ (2001). The spatial patterns of prion protein deposits in Creutzfeldt-Jakob disease: comparison with beta-amyloid deposits in Alzheimer's disease. Neurosci Lett, 298(1), 53-56. Abstract. Author URL.
Court JA, Ballard CG, Piggott MA, Johnson M, O'Brien JT, Holmes C, Cairns N, Lantos P, Perry RH, Jaros E, et al (2001). Visual hallucinations are associated with lower αbungarotoxin binding in dementia with Lewy bodies. Pharmacology Biochemistry and Behavior, 70(4), 571-579. Abstract.
Armstrong RA, Cairns NJ, Lantos PL (2001). What does the study of the spatial patterns of pathological lesions tell us about the pathogenesis of neurodegenerative disorders?. Neuropathology, 21(1), 1-12. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2000). A quantitative study of the pathological lesions in the neocortex and hippocampus of twelve patients with corticobasal degeneration. Exp Neurol, 163(2), 348-356. Abstract. Author URL.
Pickering-Brown SM, Owen F, Isaacs A, Snowden J, Varma A, Neary D, Furlong R, Daniel SE, Cairns NJ, Mann DM, et al (2000). Apolipoprotein E ε4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with Pick- or microvacuolar-type histology. EXPERIMENTAL NEUROLOGY, 163(2), 452-456. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2000). Beta-amyloid deposition in the temporal lobe of patients with dementia with Lewy bodies: Comparison with non-demented cases and Alzheimer's disease. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 11(4), 187-192. Author URL.
Eckert GP, Cairns NJ, Maras A, Gattaz WF, Müller WE (2000). Cholesterol modulates the membrane-disordering effects of beta-amyloid peptides in the hippocampus: specific changes in Alzheimer's disease. Dement Geriatr Cogn Disord, 11(4), 181-186. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (2000). Clustering of Pick bodies in the dentate gyrus in Pick's disease. NEUROPATHOLOGY, 20(3), 170-175. Author URL.
Shiozawa M, Fukutani Y, Sasaki K, Isaki K, Hamano T, Hirayama M, Imamura K, Mukai M, Arai N, Cairns NJ, et al (2000). Corticobasal degeneration: an autopsy case clinically diagnosed as progressive supranuclear palsy. Clin Neuropathol, 19(4), 192-199. Abstract. Author URL.
Kim SH, Vlkolinsky R, Cairns N, Lubec G (2000). Decreased levels of complex III core protein 1 and complex V β chain in brains from patients with Alzheimer's disease and down syndrome. Cellular and Molecular Life Sciences, 57(12), 1810-1816. Abstract.
Ballard C, Piggott M, Johnson M, Cairns N, Perry R, McKeith I, Jaros E, O'Brien J, Holmes C, Perry E, et al (2000). Delusions associated with elevated muscarinic binding in dementia with Lewy bodies. Annals of Neurology, 48(6), 868-876. Abstract.
Bell K, Cairns NJ, Lantos PL, Rossor MN (2000). Immunohistochemistry distinguishes: between Pick's disease and corticobasal degeneration. J Neurol Neurosurg Psychiatry, 69(6), 835-836. Author URL.
Gulesserian T, Engidawork E, Cairns N, Lubec G (2000). Increased protein levels of serotonin transporter in frontal cortex of patients with Down syndrome. Neuroscience Letters, 296(1), 53-57. Abstract.
Arranz MJ, Pons J, Gutierrez B, Mulcrone J, Cairns N, Makoff A, Kerwin R (2000). Investigation of 5-HT2A differential expression and imprinting in schizophrenia. American Journal of Medical Genetics - Neuropsychiatric Genetics, 96(4). Abstract.
Armstrong RA, Lantos PL, Cairns NJ (2000). Laminar distribution of ballooned neurons and tau positive neurons with inclusions in patients with corticobasal degeneration. NEUROSCIENCE RESEARCH COMMUNICATIONS, 27(2), 85-93. Author URL.
Morris HR, Vaughan JR, Datta SR, Bandopadhyay R, Rohan De Silva HA, Schrag A, Cairns NJ, Burn D, Nath U, Lantos PL, et al (2000). Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE. Neurology, 55(12), 1918-1920. Abstract. Author URL.
Kim SH, Yoo BC, Broers JLV, Cairns N, Lubec G (2000). Neuroendocrine-specific protein C, a marker of neuronal differentiation, is reduced in brain of patients with down syndrome and Alzheimer's disease. Biochemical and Biophysical Research Communications, 276(1), 329-334. Abstract.
Fukutani Y, Cairns NJ, Shiozawa M, Sasaki K, Sudo S, Isaki K, Lantos PL (2000). Neuronal loss and neurofibrillary degeneration in the hippocampal cortex in late-onset sporadic Alzheimer's disease. PSYCHIATRY AND CLINICAL NEUROSCIENCES, 54(5), 523-529. Author URL.
Pickering-Brown S, Baker M, Yen SH, Liu WK, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, et al (2000). Pick's disease is associated with mutations in the tau gene. Annals of Neurology, 48(6), 859-867. Abstract.
Eastwood SL, Cairns NJ, Harrison PJ (2000). Synaptophysin gene expression in schizophrenia. Investigation of synaptic pathology in the cerebral cortex. Br J Psychiatry, 176, 236-242. Abstract. Author URL.
Narain Y, Furlong RA, Robinsztein DC, Yip A, Murphy T, Brayne C, Easton D, Evans JG, Xuereb J, Cairns N, et al (2000). The ACE gene and Alzheimer's disease susceptibility. Journal of Medical Genetics, 37(9), 695-697. Abstract.
Armstrong RA, Cairns NJ, Lantos PL (2000). The spatial pattern of the vacuolation in patients with sporadic Creutzfeldt-Jakob disease. Neurosci Lett, 281(2-3), 187-190. Abstract. Author URL.
Dow DJ, Lindsey N, Cairns NJ, Brayne C, Robinson D, Huppert FA, Paykel ES, Xuereb J, Wilcock G, Whittaker JL, et al (1999). Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK. Nat Genet, 22(1), 16-17. Author URL.
Kovács T, Cairns NJ, Lantos PL (1999). Alpha-2-macroglobulin intronic polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease. Neurosci Lett, 273(1), 61-83. Abstract. Author URL.
Kitzmueller E, Labudova O, Rink H, Cairns N, Lubec G (1999). Altered gene expression in fetal Down Syndrome brain as revealed by the gene hunting technique of subtractive hybridization. Journal of Neural Transmission, Supplement(57), 99-124. Abstract.
Seidl R, Fang-Kircher S, Bidmon B, Cairns N, Lubec G (1999). Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome. Neuroscience Letters, 260(1), 9-12. Abstract.
Greber-Platzer S, Balcz B, Cairns N, Lubec G (1999). C-fos expression in brains of patients with Down Syndrome. Journal of Neural Transmission, Supplement(57), 75-85. Abstract.
Fukutani Y, Cairns NJ, Everall IP, Chadwick A, Isaki K, Lantos PL (1999). Cerebellar dentate nucleus in Alzheimer's disease with myoclonus. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 10(2), 81-88. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1999). Clustering of cerebral cortical lesions in patients with corticobasal degeneration. Neurosci Lett, 268(1), 5-8. Abstract. Author URL.
Guan Z, Wang Y, Cairns NJ, Lantos PL, Dallner G, Sindelar PJ (1999). Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease. J Neuropathol Exp Neurol, 58(7), 740-747. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1999). Degeneration of cortical neurons associated with diffuse β-amyloid (Aβ) deposits in Alzheimer's disease. NEUROSCIENCE RESEARCH COMMUNICATIONS, 24(2), 89-97. Author URL.
Rao R, Holmes C, Cairns N (1999). Detecting vascular pathology in vascular dementia [7] (multiple letters). British Journal of Psychiatry, 174(JUN.), 562-563.
Schatzmann-Turhani D, Greber-Platzer S, Cairns N, Lubec G (1999). Determination of the protooncogene ets-2 gene transcript in human brain at the atto-gram-level by the use of competitive RT/PCR. Amino Acids, 16(1), 13-19. Abstract.
Krapfenbauer K, Yoo BC, Cairns N, Lubec G (1999). Differential display reveals deteriorated mRNA levels of NADH3 (complex I) in cerebellum of patients with Down Syndrome. Journal of Neural Transmission, Supplement(57), 211-220. Abstract.
Yeghiazaryan K, Turhani-Schatzmann D, Labudova O, Schuller E, Olson EN, Cairns N, Lubec G (1999). Downregulation of the transcription factor scleraxis in brain of patients with Down Syndrome. Journal of Neural Transmission, Supplement(57), 305-314. Abstract.
Karlsson K, Cairns N, Lubec G, Fountoulakis M (1999). Enrichment of human brain proteins by heparin chromatography. Electrophoresis, 20(14), 2970-2976. Abstract.
Lubec G, Nonaka M, Krapfenbauer K, Gratzer M, Cairns N, Fountoulakis M (1999). Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer's disease brain is downregulated at the mRNA and dysregulated at the protein level. Journal of Neural Transmission, Supplement(57), 161-177. Abstract.
Greber-Platzer S, Schatzmann-Turhani D, Cairns N, Balcz B, Lubec G (1999). Expression of the transcription factor ETS2 in brain of patients with Down Syndrome - Evidence against the overexpression-gene dosage hypothesis. Journal of Neural Transmission, Supplement(57), 269-281. Abstract.
Labudova O, Kitzmueller E, Rink H, Cairns N, Lubec G (1999). Gene expression in fetal Down Syndrome brain as revealed by subtractive hybridization. Journal of Neural Transmission, Supplement(57), 125-136. Abstract.
Yoo BC, Seidl R, Cairns N, Lubec G (1999). Heat-shock protein 70 levels in brain of patients with Down Syndrome and Alzheimer's disease. Journal of Neural Transmission, Supplement(57), 315-322. Abstract.
Labudova O, Cairns N, Kitzmüller E, Lubec G (1999). Impaired brain glucose metabolism in patients with Down Syndrome. Journal of Neural Transmission, Supplement(57), 247-256. Abstract.
Lubec G, Labudova O, Cairns N, Fountoulakis M (1999). Increased glyceraldehyde 3-phosphate dehydrogenase levels in the brain of patients with Down's syndrome. Neuroscience Letters, 260(2), 141-145. Abstract.
Fountoulakis M, Cairns N, Lubec G (1999). Increased levels of 14-3-3 gamma and epsilon proteins in brain of patients with Alzheimer's disease and Down Syndrome. Journal of Neural Transmission, Supplement(57), 323-335. Abstract.
Labudova O, Kitzmueller E, Rink H, Cairns N, Lubec G (1999). Increased phosphoglycerate kinase in the brains of patients with Down's syndrome but not with Alzheimer's disease. Clinical Science, 96(3), 279-285. Abstract.
Fang-Kircher SG, Labudova O, Kitzmueller E, Rink H, Cairns N, Lubec G (1999). Increased steady state mRNA levels of DNA-repair genes XRCC1, ERCC2 and ERCC3 in brain of patients with Down Syndrome. Life Sciences, 64(18), 1689-1699. Abstract.
Armstrong RA, Cairns NJ, Lantos PL (1999). Laminar distribution of pick bodies, pick cells and Alzheimer disease pathology in the frontal and temporal cortex in Pick's disease. Neuropathol Appl Neurobiol, 25(4), 266-271. Abstract. Author URL.
Seidl R, Bajo M, Böhm K, LaCasse EC, MacKenzie AE, Cairns N, Lubec G (1999). Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in brains of adult patients with Down syndrome. Journal of Neural Transmission, Supplement(57), 283-291. Abstract.
Court J, Spurden D, Lloyd S, McKeith I, Ballard C, Cairns N, Kerwin R, Perry R, Perry E (1999). Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: alpha-bungarotoxin and nicotine binding in the thalamus. J Neurochem, 73(4), 1590-1597. Abstract. Author URL.
Cairns NJ (1999). Neuropathology. J Neural Transm Suppl, 57, 61-74. Author URL.
Schatzmann-Turhani D, Labudova O, Yeghiazaryan K, Rink H, Hauser E, Cairns N, Lubec G (1999). Overexpression of DNAse I in brain of patients with Down Syndrome. Journal of Neural Transmission, Supplement(57), 353-362. Abstract.
Eckert GP, Cairns NJ, Müller WE (1999). Piracetam reverses hippocampal membrane alterations in Alzheimer's disease. J Neural Transm (Vienna), 106(7-8), 757-761. Abstract. Author URL.
Ballard C, Holmes C, McKeith I, Neill D, O'Brien J, Cairns N, Lantos P, Perry E, Ince P, Perry R, et al (1999). Psychiatric morbidity in dementia with Lewy bodies: a prospective clinical and neuropathological comparative study with Alzheimer's disease. Am J Psychiatry, 156(7), 1039-1045. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1999). Quantification of pathological lesions in the frontal and temporal lobe of ten patients diagnosed with Pick's disease. ACTA NEUROPATHOLOGICA, 97(5), 456-462. Author URL.
Lubec G, Labudova O, Cairns N, Berndt P, Langen H, Fountoulakis M (1999). Reduced aldehyde dehydrogenase levels in the brain of patients with Down Syndrome. Journal of Neural Transmission, Supplement(57), 21-40. Abstract.
Seidl R, Kaehler ST, Prast H, Singewald N, Cairns N, Gratzer M, Lubec G (1999). Serotonin (5-HT) in brains of adult patients with Down syndrome. Journal of Neural Transmission, Supplement(57), 221-232. Abstract.
Gómez-Isla T, Growdon WB, McNamara MJ, Nochlin D, Bird TD, Arango JC, Lopera F, Kosik KS, Lantos PL, Cairns NJ, et al (1999). The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors. Brain, 122 ( Pt 9), 1709-1719. Abstract. Author URL.
Armstrong R, Cairns N, Lantos P (1999). The spatial patterns of Pick bodies, Pick cells and Alzheimer's disease pathology in Pick's disease. Neuropathology, 19(1), 64-70. Abstract.
Labudova O, Cairns N, Thomas K, Kitzmueller E, Rink H, Lubec G (1999). Thyroid stimulating hormone-receptor overexpression in brain of patients with Down syndrome and Alzheimer's disease. Life Sciences, 64(12), 1037-1044. Abstract.
Holmes C, Cairns N, Lantos P, Mann A (1999). Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies. British Journal of Psychiatry, 174(JAN.), 45-50. Abstract.
Kehoe PG, Russ C, McIlory S, Williams H, Holmans P, Holmes C, Liolitsa D, Vahidassr D, Powell J, McGleenon B, et al (1999). Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nat Genet, 21(1), 71-72. Author URL.
Kovács T, Cairns NJ, Lantos PL (1999). beta-amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Alzheimer's disease. Neuropathol Appl Neurobiol, 25(6), 481-491. Abstract. Author URL.
Kovács T, Cairns NJ, Lantos PL (1999). β-amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Alzheimer's disease. Neuropathology and Applied Neurobiology, 25(6), 481-491. Abstract.
Armstrong RA, Cairns NJ, Lantos PL (1998). A comparison of histological and immunohistochemical methods for quantifying the pathological lesions of Pick's disease. NEUROPATHOLOGY, 18(3), 295-300. Author URL.
Tysoe C, Whittaker J, Xuereb J, Cairns NJ, Cruts M, Van Broeckhoven C, Wilcock G, Rubinsztein DC (1998). A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer disease. Am J Hum Genet, 62(1), 70-76. Abstract. Author URL.
Labudova O, Fang-Kircher S, Cairns N, Moenkemann H, Yeghiazaryan K, Lubec G (1998). Brain vasopressin levels in Down Syndrome and Alzheimer's disease. Brain Research, 806(1), 55-59. Abstract.
Armstrong RA, Cairns NJ, Lantos PL (1998). Clustering of Pick bodies in patients with Pick's disease. NEUROSCIENCE LETTERS, 242(2), 81-84. Author URL.
Labudova O, Krapfenbauer K, Moenkemann H, Rink H, Kitzmüller E, Cairns N, Lubec G (1998). Decreased transcription factor junD in brains of patients with Down syndrome. Neuroscience Letters, 252(3), 159-162. Abstract.
Müller WE, Eckert GP, Scheuer K, Cairns NJ, Maras A, Gattaz WF (1998). Effects of beta-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of a beta 1-42 and a beta 1-43. Amyloid, 5(1), 10-15. Abstract. Author URL.
Hermon M, Cairns N, Egly JM, Fery A, Olga Labudova, Lubec G (1998). Expression of DNA excision-repair-cross-complementing proteins p80 and p89 in brain of patients with Down Syndrome and Alzheimer's disease. Neuroscience Letters, 251(1), 45-48. Abstract.
Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M (1998). Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett, 251(3), 205-208. Abstract. Author URL.
Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St George-Hyslop P, et al (1998). Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes. Am J Pathol, 153(5), 1365-1370. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1998). Lewy body and Alzheimer pathology in temporal lobe in dementia with Lewy bodies. ALZHEIMERS REPORTS, 1(3), 159-163. Author URL.
Rossor M, Alvarez XA, Barker S, Binetti G, Boller F, Bracco L, Breteler M, Brun A, Cacabelos R, Cairns N, et al (1998). Provisional clinical and neuroradiological criteria for the diagnosis of Pick's disease. European Journal of Neurology, 5(5), 519-520.
Armstrong RA, Cairns NJ, Lantos PL (1998). Spatial distribution of diffuse, primitive, and classic amyloid-beta deposits and blood vessels in the upper laminae of the frontal cortex in Alzheimer disease. Alzheimer Dis Assoc Disord, 12(4), 378-383. Abstract. Author URL.
Kehoe PG, Williams H, Holmans P, Wilcock G, Cairns NJ, Neal J, Owen MJ (1998). The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. J Med Genet, 35(12), 1034-1035. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1998). The spatial pattern of ß-amyloid (Aß) deposits in Alzheimer's disease patients is related to apolipoprotein genotype. Neuroscience Research Communications, 22(2), 99-106. Abstract.
Armstrong RA, Cairns NJ, Lantos PL (1998). The spatial pattern of β-amyloid (Aβ) deposits in Alzheimer's disease patients is related to apolipoprotein genotype. NEUROSCIENCE RESEARCH COMMUNICATIONS, 22(2), 99-106. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1998). The spatial patterns of Lewy bodies, senile plaques, and neurofibrillary tangles in dementia with Lewy bodies. Exp Neurol, 150(1), 122-127. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1998). The spatial patterns of β-amyloid (Aβ) deposits in dementia with Lewy bodies and Alzheimer's disease. Alzheimer's Research, 4(1), 5-9. Abstract.
Sawa A, Oyama F, Cairns NJ, Amano N, Matsushita M (1997). Aberrant expression of bcl-2 gene family in Down's syndrome brains. MOLECULAR BRAIN RESEARCH, 48(1), 53-59. Author URL.
Lyras L, Cairns NJ, Jenner A, Jenner P, Halliwell B (1997). An assessment of oxidative damage to proteins, lipids, and DNA in brain from patients with Alzheimer's disease. J Neurochem, 68(5), 2061-2069. Abstract. Author URL.
Cairns NJ, Atkinson PF, Kovacs T, Lees AJ, Daniel SE, Lantos PL (1997). Apolipoprotein E e4 allele frequency in patients with multiple system atrophy. NEUROSCIENCE LETTERS, 221(2-3), 161-164. Author URL.
Cairns NJ, Fukutani Y, Chadwick A, Barnes H, Holmes C, Lantos PL (1997). Apolipoprotein E, β-amyloid (Aβ), phosphorylated tau and apoilpoprotein E genotype in Alzheimer's disease. Alzheimer's Research, 3(3), 109-114. Abstract.
Fukutani Y, Cairns NJ, Rossor MN, Lantos PL (1997). Cerebellar pathology in sporadic and familial Alzheimer's disease including APP 717 (Val->Ile) mutation cases: a morphometric investigation. JOURNAL OF THE NEUROLOGICAL SCIENCES, 149(2), 177-184. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1997). Dementia with Lewy bodies: Clustering of Lewy bodies in human patients. NEUROSCIENCE LETTERS, 224(1), 41-44. Author URL.
Seidl R, Schuller E, Cairns N, Lubec G (1997). Evidence against increased glycoxidation in patients with Alzheimer's disease. Neuroscience Letters, 232(1), 49-52. Abstract.
Seidl R, Greber S, Schuller E, Bernert G, Cairns N, Lubec G (1997). Evidence against increased oxidative DNA-damage in down syndrome. Neuroscience Letters, 235(3), 137-140. Abstract.
Risser D, Lubec G, Cairns N, Herrera-Marschitz M (1997). Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome. Life Sciences, 60(15), 1231-1237. Abstract.
Rezaie P, Cairns NJ, Male DK (1997). Expression of adhesion molecules on human fetal cerebral vessels: relationship to microglial colonisation during development. DEVELOPMENTAL BRAIN RESEARCH, 104(1-2), 175-189. Author URL.
Duberley RM, Johnson IP, Anand P, Leigh PN, Cairns NJ (1997). Immunocytochemical studies of neurotrophins in cerebral motor cortex in Amyotrophic Lateral Sclerosis. Brain Res, 763(2), 259-263. Abstract. Author URL.
Armstrong RA, Cairns NJ, Lantos PL (1997). Laminar distribution of cortical lewy bodies and neurofibrillary tangles in dementia with Lewy bodies. NEUROSCIENCE RESEARCH COMMUNICATIONS, 21(2), 145-152. Author URL.
Fukutani Y, Sasaki K, Mukai M, Matsubara R, Isaki K, Cairns NJ (1997). Neurons and extracellular neurofibrillary tangles in the hippocampal subdivisions in early-onset familial Alzheimer's disease: a case study. PSYCHIATRY AND CLINICAL NEUROSCIENCES, 51(4), 227-231. Author URL.
Sasaki K, Fukutani Y, Mukai M, Cairns NJ, Isaki K (1997). Neurons and neurofibrillary tangles in the hippocampal cortex in familial and sporadic Alzheimer's disease. NEUROPATHOLOGY, 17(4), 301-306. Author URL.
Duberley RM, Johnson IP, Anand P, Leigh PN, Cairns NJ (1997). Neurotrophin-3-like immunoreactivity and Trk C expression in human spinal motoneurones in amyotrophic lateral sclerosis. JOURNAL OF THE NEUROLOGICAL SCIENCES, 148(1), 33-40. Author URL.
Jones AL, Middle F, Guy C, Spurlock G, Cairns NJ, McGuffin P, Craddock N, Owen M, O'Donovan MC (1997). No evidence for expanded polyglutamine sequences in bipolar disorder and schizophrenia. Mol Psychiatry, 2(6), 478-482. Abstract. Author URL.
Alam ZI, Jenner A, Daniel SE, Lees AJ, Cairns N, Marsden CD, Jenner P, Halliwell B (1997). Oxidative DNA damage in the Parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. Journal of Neurochemistry, 69(3), 1196-1203. Abstract.
Tysoe C, Whittaker J, Cairns NJ, Atkinson PF, Harrington CR, Xuereb J, Wilcock G, Rubinsztein DC (1997). Presenilin-1 intron 8 polymorphism is not associated with autopsy-confirmed late-onset Alzheimer's disease. Neurosci Lett, 222(1), 68-69. Abstract. Author URL.
Cairns NJ, Atkinson PF, Hanger DP, Anderton BH, Daniel SE, Lantos PL (1997). Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease. Neurosci Lett, 230(1), 49-52. Abstract. Author URL.
Cairns NJ (1997). The neuropathology of dementia. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 12(12), 1197-1197. Author URL.
Marshall KA, Daniel SE, Cairns N, Jenner P, Halliwell B (1997). Upregulation of the anti-apoptotic protein Bcl-2 may be an early event in neurodegeneration: Studies on Parkinson's and Incidental Lewy Body Disease. Biochemical and Biophysical Research Communications, 240(1), 84-87. Abstract.
Armstrong RA, Cairns NJ, Lantos PL (1997). beta-amyloid (A beta) deposition in the medial temporal lobe of patients with dementia with Lewy bodies. NEUROSCIENCE LETTERS, 227(3), 193-196. Author URL.
Armstrong RA, Cairns NJ, Myers D, Smith CU, Lantos PL, Rossor MN (1996). A comparison of beta-amyloid deposition in the medial temporal lobe in sporadic Alzheimer's disease, Down's syndrome and normal elderly brains. Neurodegeneration, 5(1), 35-41. Abstract. Author URL.
Mann DM, Iwatsubo T, Cairns NJ, Lantos PL, Nochlin D, Sumi SM, Bird TD, Poorkaj P, Hardy J, Hutton M, et al (1996). Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43). Ann Neurol, 40(2), 149-156. Abstract. Author URL.
Cairns NJ, Fukutani Y, Chadwick A, Lantos PL (1996). Apolipoprotein E, phosphorylated tau and beta-amyloid deposition in Alzheimer's disease. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 22(5), 452-452. Author URL.
Cairns NJ, Lantos PL (1996). Brain tissue banks in psychiatric and neurological research. J Clin Pathol, 49(11), 870-873. Author URL.
Fukutani Y, Cairns NJ, Rossor MN, Lantos PL (1996). Cerebellar pathology in sporadic and familial Alzheimer's disease including APP 717 (Val->Ile) mutation cases. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 22(5), 452-452. Author URL.
Scheuer K, Maras A, Gattaz WF, Cairns N, Förstl H, Müller WE (1996). Cortical NMDA receptor properties and membrane fluidity are altered in alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 7(4), 210-214. Abstract.
Bernert G, Nemethova M, Herrera-Marschitz M, Cairns N, Lubec G (1996). Decreased cyclin dependent kinase in brain of patients with Down syndrome. Neuroscience Letters, 216(1), 68-70. Abstract.
Gattaz WF, Cairns NJ, Levy R, Forstl H, Braus DF, Maras A (1996). Decreased phospholipase A(2) activity in the brain and in platelets of patients with Alzheimer's disease. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 246(3), 129-131. Author URL.
Gattaz WF, Levy R, Cairns NJ, Foerstl H, Braus DF, Maras A (1996). Disordered metabolism of membrane phospholipids in Alzheimer's disease. Jornal Brasileiro de Psiquiatria, 45(6), 345-349. Abstract.
Risser D, you ZB, Cairns N, Herrera-Marschitz M, Seidl R, Schneider C, Terenius L, Lubec G (1996). Endogenous opioids in frontal cortex of patients with Down syndrome. Neuroscience Letters, 203(2), 111-114. Abstract.
Muir P, Nicholson F, Spencer GT, Ajetunmobi JF, Starkey WG, Khan M, Archard LC, Cairns NJ, Anderson VE, Leigh PN, et al (1996). Enterovirus infection of the central nervous system of humans: lack of association with chronic neurological disease. J Gen Virol, 77 ( Pt 7), 1469-1476. Abstract. Author URL.
Hayn M, Kremser K, Singewald N, Cairns N, Nemethova M, Lubec B, Lubec G (1996). Evidence against the involvement of reactive oxygen species in the pathogenesis of neuronal death in Down's syndrome and Alzheimer's disease. Life Sciences, 59(7), 537-544. Abstract.
Baran H, Cairns N, Lubec B, Lubec G (1996). Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with Down syndrome. Life Sciences, 58(21), 1891-1899. Abstract.
Rezaie P, Cairns NJ, Chadwick A, Lantos PL (1996). Lewy bodies are located preferentially in limbic areas in diffuse Lewy body disease. Neurosci Lett, 212(2), 111-114. Abstract. Author URL.
Anwar R, Moynihan TP, Ardley H, Brindle N, Coletta PL, Cairns N, Markham AF, Robinson PA (1996). Molecular analysis of the presenilin 1 (S182) gene in "sporadic" cases of Alzheimer's disease: Identification and characterisation of unusual splice variants. Journal of Neurochemistry, 66(4), 1774-1777. Abstract.
Seidl R, Beninati S, Cairns N, Singewald N, Risser D, Bavan H, Nemethova M, Lubec G (1996). Polyamines in frontal cortex of patients with Down syndrome and Alzheimer disease. Neuroscience Letters, 206(2-3), 193-195. Abstract.
Mann DM, Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, Lannfelt L, Winblad B, Maat-Schieman ML, Rossor MN, et al (1996). Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. Am J Pathol, 148(4), 1257-1266. Abstract. Author URL.
Fukutani Y, Cairns NJ, Rossor MN, Lantos PL (1996). Purkinje cell loss and astrocytosis in the cerebellum in familial and sporadic Alzheimer's disease. Neurosci Lett, 214(1), 33-36. Abstract. Author URL.
Armstrong RA, Cairns NJ, Patel R, Lantos PL, Rossor MN (1996). Relationships between beta-amyloid (A beta) deposits and blood vessels in patients with sporadic and familial Alzheimer's disease. NEUROSCIENCE LETTERS, 207(3), 171-174. Author URL.
Cairns NJ, Lantos PL (1996). Surfing for brains on the World Wide Web. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 22(5), 449-449. Author URL.
Gattaz WF, Levy R, Cairns NJ, Förstl H, Braus DF, Maras A (1996). [Relevance of metabolism of membrane phospholipids for Alzheimer dementia]. Fortschr Neurol Psychiatr, 64(1), 8-12. Abstract. Author URL.
GATTAZ WF, MARAS A, CAIRNS NJ, LEVY R, FORSTL H (1995). DECREASED PHOSPHOLIPASE A(2) ACTIVITY IN ALZHEIMER BRAINS. BIOLOGICAL PSYCHIATRY, 37(1), 13-17. Author URL.
Muir P, Nicholson F, Sharief MK, Thompson EJ, Cairns NJ, Lantos P, Spencer GT, Kaminski HJ, Banatvala JE (1995). Evidence for persistent enterovirus infection of the central nervous system in patients with previous paralytic poliomyelitis. Ann N Y Acad Sci, 753, 219-232. Abstract. Author URL.
Anderson VE, Cairns NJ, Leigh PN (1995). Involvement of the amygdala, dentate and hippocampus in motor neuron disease. J Neurol Sci, 129 Suppl, 75-78. Abstract. Author URL.
Fukutani Y, Kobayashi K, Nakamura I, Watanabe K, Isaki K, Cairns NJ (1995). Neurons, intracellular and extracellular neurofibrillary tangles in subdivisions of the hippocampal cortex in normal ageing and Alzheimer's disease. Neurosci Lett, 200(1), 57-60. Abstract. Author URL.
Kingsbury AE, Foster OJF, Nisbet AP, Cairns N, Bray L, Eve DJ, Lees AJ, David Marsden C (1995). Tissue pH as an indicator of mRNA preservation in human post-mortem brain. Molecular Brain Research, 28(2), 311-318. Abstract.
Forstl H, Levy R, Burns A, Luthert P, Cairns N (1994). Disproportionate loss of noradrenergic and cholinergic neurons as cause of depression in Alzheimer's disease - a hypothesis. Pharmacopsychiatry, 27(1), 11-15. Abstract.
Oyama F, Cairns NJ, Shimada H, Oyama R, Titani K, Ihara Y (1994). Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination. J Neurochem, 62(3), 1062-1066. Abstract. Author URL.
Forstl H, Burns A, Levy R, Cairns N (1994). Neuropathological correlates of psychotic phenomena in confirmed Alzheimer's disease. British Journal of Psychiatry, 164(JULY), 53-59. Abstract.
Forstl H, Levy R, Burns A, Luthert P, Cairns N (1994). Pathways and patterns of cell loss in verified Alzheimer's disease: a factor and cluster analysis of clinico-pathological subgroups. Behavioural Neurology, 7(3-4), 175-180. Abstract.
Förstl H, Levy R, Burns A, Luthert P, Cairns N (1994). Pathways and patterns of cell loss in verified Alzheimer’s disease: a factor and cluster analysis of clinico-pathological subgroups. Behavioural Neurology, 7(3-4), 175-180. Abstract.
Cairns NJ, Chadwick A, Lantos PL, Levy R, Rossor MN (1993). Beta A4 protein deposition in familial Alzheimer's disease with the mutation in codon 717 of the beta A4 amyloid precursor protein gene and sporadic Alzheimer's disease. Neurosci Lett, 149(2), 137-140. Abstract. Author URL.
Ghauri FY, Nicholson JK, Sweatman BC, Wood J, Beddell CR, Lindon JC, Cairns NJ (1993). NMR spectroscopy of human post mortem cerebrospinal fluid: distinction of Alzheimer's disease from control using pattern recognition and statistics. NMR Biomed, 6(2), 163-167. Abstract. Author URL.
Förstl H, Burns A, Levy R, Cairns N (1993). Neuropathological basis for drawing disability (constructional apraxia) in Alzheimer's disease. Psychological Medicine, 23(3), 623-629. Abstract.
Forstl H, Burns A, Levy R, Cairns N, Luthert P, Lantos P (1993). Neuropathological correlates of behavioural disturbance in confirmed Alzheimer's disease. British Journal of Psychiatry, 163(SEPT.), 364-368. Abstract.
Forstl H, Burns A, Luthert P, Cairns N, Levy R (1993). The Lewy-body variant of Alzheimer's disease. Clinical and pathological findings. British Journal of Psychiatry, 162(MAR.), 385-392. Abstract.
Cairns NJ, Chadwick A, Luthert PJ, Lantos PL (1992). Astrocytosis, beta A4-protein deposition and paired helical filament formation in Alzheimer's disease. J Neurol Sci, 112(1-2), 68-75. Abstract. Author URL.
Förstl H, Burns A, Cairns N, Luthert P, Levy R (1992). Basal ganglia mineralization in alzheimer's disease: a comparative study of clinical, neuroradiological and neuropathological findings. Behavioural Neurology, 5(1), 53-57. Abstract.
Förstl H, Burns A, Luthert P, Cairns N, Lantos P, Levy R (1992). Clinical and neuropathological correlates of depression in Alzheimer's disease. Psychological Medicine, 22(4), 877-884.
Förstl H, Burns A, Levy R, Cairns N, Luthert P, Lantos P (1992). Neurologic Signs in Alzheimer's Disease: Results of a Prospective Clinical and Neuropathologic Study. Archives of Neurology, 49(10), 1038-1042. Abstract.
Forstl H, Burns A, Cairns N, Luthert P, Lantos P, Levy R (1992). Neuropathological correlates of affective disturbances in Alzheimer's disease. A review and results of a prospective study. Nervenarzt, 63(9), 566-574. Abstract.
Goedert M, Spillantini MG, Cairns NJ, Crowther RA (1992). Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron, 8(1), 159-168. Abstract. Author URL.
Armstrong RA, Myers D, Smith CUM, Cairns N, Luthert PJ (1992). The spatial pattern of senile plaques, neurofibrillary tangles and A4 deposits in Alzheimer's disease. Neuroscience Research Communications, 10(1), 27-33.
Armstrong RA, Myers D, Smith CUM, Cairns N, Luthert PJ (1991). Alzheimer's disease: the relationship between the density of senile plaques, neurofibrillary tangles and A4 protein in human patients. Neuroscience Letters, 123(2), 141-143. Abstract.
Forstl H, Burns A, Luthert P, Cairns N (1991). Dementia and internal medical disorders. Zeitschrift fur Gerontologie, 24(2), 91-93.
Förstl H, Cairns N, Burns A, Luthert P (1991). Medical disorders in Alzheimer's disease and vascular dementia. Postgraduate Medical Journal, 67(790), 742-744. Abstract.
HANGER DP, BRION JP, GALLO JM, CAIRNS NJ, LUTHERT PJ, ANDERTON BH (1991). TAU IN ALZHEIMERS-DISEASE AND DOWNS-SYNDROME IS INSOLUBLE AND ABNORMALLY PHOSPHORYLATED. BIOCHEMICAL JOURNAL, 275, 99-104. Author URL.
Cairns NJ, Chadwick A, Luthert PJ, Lantos PL (1991). beta-Amyloid protein load is relatively uniform throughout neocortex and hippocampus in elderly Alzheimer's disease patients. Neurosci Lett, 129(1), 115-118. Abstract. Author URL.
Cairns NJ, Wonnacott S (1988). [3H](-)nicotine binding sites in fetal human brain. Brain Res, 475(1), 1-7. Abstract. Author URL.
Thomas JE, Abson CP, Cairns NJ (1981). Pulmonary embolism. A hazard of air travel. Cent Afr J Med, 27(5), 85-87. Author URL.
Chapters
Hortobágyi T, Cairns NJ (2014). Amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In (Ed) Neuropathology of Neurodegenerative Diseases: a Practical Guide, 209-248. Abstract.
Cairns NJ (2011). Neuronal Intermediate Filament Inclusion Disease. In (Ed) Neurodegeneration: the Molecular Pathology of Dementia and Movement Disorders: Second Edition, 404-411. Abstract.
Cairns NJ (2009). Alzheimer's disease: Neurodegeneration. In (Ed) Encyclopedia of Neuroscience, 275-281. Abstract.
Greber S, Lubec G, Cairns N, Fountoulakis M (2007). Decreased levels of synaptosomal associated protein 25 in the brain of patients with down syndrome and alzheimer's disease. In (Ed) From Genome to Proteome: Advances in the Practice & Application of Proteomics, 348-354. Abstract.
Langen H, Berndt P, Röder D, Cairns N, Lubec G, Fountoulakis M (2007). Two-dimensional map of human brain proteins. In (Ed) From Genome to Proteome: Advances in the Practice & Application of Proteomics, 327-336. Abstract.
Conferences
Cairns NJ, McKee AC, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel J-P, Stewart W, et al (2019). Consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. Author URL.
Cairns NJ (2019). Neuropathologic heterogeneity in autosomal dominant and late-onset Alzheimer disease. Author URL.
Myers PS, Campbell MC, Weigand AJ, Cairns NJ, Jackson JJ, Lessov-Schlaggar CN, Perlmutter JS (2019). Parkinson Disease Clinical Subtypes Predict Dementia and Mortality Risk. Author URL.
Du L, Liu K, Yao X, Risacher SL, Han J, Guo L, Saykin AJ, Shen L, Weiner M, Aisen P, et al (2018). Fast Multi-Task SCCA Learning with Feature Selection for Multi-Modal Brain Imaging Genetics. Author URL.
Zheng Q, Fan Y, Weiner MW, Aisen P, Aisen P, Petersen R, Jack CRJ, Jagust W, Trojanowki JQ, Toga AW, et al (2018). INTEGRATING SEMI-SUPERVISED LABEL PROPAGATION AND RANDOM FORESTS FOR MULTI-ATLAS BASED HIPPOCAMPUS SEGMENTATION. Author URL.
Liu K, Wang H, Risacher S, Saykin A, Shen L, Weiner M, Aisen P, Petersen R, Jack CRJ, Jagust W, et al (2018). MULTIPLE INCOMPLETE VIEWS CLUSTERING VIA NON-NEGATIVE MATRIX FACTORIZATION WITH ITS APPLICATION IN ALZHEIMER'S DISEASE ANALYSIS. Author URL.
Lu L, Wang H, Yao X, Risacher S, Saykin A, Shen L, Weiner MW, Aisen P, Petersen R, Jack CRJ, et al (2018). PREDICTING PROGRESSIONS OF COGNITIVE OUTCOMES VIA HIGH-ORDER MULTI-MODAL MULTI-TASK FEATURE LEARNING. Author URL.
Yamasaki TR, Holmes BB, Furman JL, Dhavale DD, Cairns NJ, Kotzbauer PT, Diamond MI (2016). Distinct Synuclein Seeds in Parkinson Disease and Multiple System Atrophy. Author URL.
Ferrari R, Hernandez DG, Nalls MA, Rohrer JD, Ramasamy A, Kwok JBJ, Dobson-Stone C, Brooks WS, Eld PRS, Halliday GM, et al (2014). Genetic analysis suggests lysosomal and immune system involvement in frontotemporal dementia. Author URL.
Schofield PR, Bateman RJ, Xiong C, Benzinger TLS, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, et al (2013). CLINICAL AND BIOMARKER CHANGES IN DOMINANTLY INHERITED ALZHEIMER'S DISEASE. Author URL.
Campbell MC, Markham J, Flores H, Hartlein JM, Goate AM, Cairns NJ, Videen TO, Perlmutter JS (2013). Principal component analysis of PiB distribution in Parkinson's and Alzheimer's diseases. Author URL.
Cairns NJ (2012). Mechanisms of Disease in FTLD - TDP-43 loss of function. Author URL.
Rademakers R, Baker M, Nicholson A, Rutherford N, Finch N, Soto-Ortolaza A, Wider C, Wojtas A, DeJesus-Hernandez M, Kouri N, et al (2012). Mutations in the colony stimulating factor 1 receptor (<i>CSF1R</i>) cause hereditary diffuse leukoencephalopathy with spheroids. Author URL.
Campbell MC, Kotzbauer PT, Cairns NJ, Willis AW, Racette BA, Tabbal SD, Perlmutter JS (2012). Pathological Accumulation of α-Synuclein and Aβ in Dementia Associated with Parkinson Disease. Author URL.
Campbell MC, Kotzbauer PT, Cairns NJ, Racette BA, Tabbal SD, Perlmutter JS (2012). Pathological accumulation of α-synuclein and Aβ in Parkinson's disease with dementia. Author URL.
Liscic RM, Behrens MI, Morris JC, Cairns NJ (2009). HDDD with Alzheimer's disease as common comorbidity: a clinicopathologic case report. Author URL.
Cairns NJ (2009). NEUROPATHOLOGY OF TDP-43 PROTEINOPATHY. Author URL.
Gitcho M, Mukherjee O, Wang J, Chakraverty S, Strider J, Norton J, Goate A, Cairns NJ (2008). An alternative <i>in vitro</i> model of neurodegeneration in FTLD-U with <i>PGRN</i> mutation. Author URL.
Gitcho M, Mukherjee O, Wang J, Chakraverty S, Strider J, Norton J, Goate A, Cairns NJ (2008). ERRORAn alternative in vitro model of neurodegeneration in FTLD-U with PGRN mutation. Author URL.
Roe CM, Xiong C, Miller JP, Cairns NJ, Morris JC (2008). Interaction of neuritic plaques and education predicts dementia. Author URL.
Liscic RM, Behrens MI, Mukherjee O, Tu P-H, Chakraverty S, Norton JB, Goate A, Morris JC, Cairns NJ (2007). Frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation in two kindreds. Author URL.
Hatanpaa KJ, Bigio EH, Cairns NJ, Schneider JA, Foong C, Hladik C, Shang P, White CLIII (2007). TDP-43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a Midwest-Southwest Consortium for FTLD study. Author URL.
Forman MS, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Neumann M (2007). TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. Author URL.
Neumann M, Kwong LK, Sampathu DM, Mackenzie IR, Kretzschmar HA, Cairns NJ, Trojanowski JQ, Lee VM-Y (2007). Ubiquinated and phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Author URL.
Cairns NJ, Grinberg LT, Liscic RM, Tu P, Morris JC (2006). Expanding the neuropathological spectrum of frontotemporal lobar degenerations: review of 833 prospectively assessed dementia cases. Author URL.
Cairns NJ, Tu P-H, Bigio EH, Schneider JA, White CL, Hatanpaa KJ, Aggarwal NT, Womack KB, Schneider S, Grinberg LT, et al (2006). Neuropathologic heterogeneity in FTLD with ubiquitin inclusions: Report of the midwest consortium for FTLD. Author URL.
Mosaheb S, Hashemzadeh-Bonehi L, Rulten SL, Kay JE, Thorpe JR, Cairns NJ (2005). Fine structure of intranuclear inclusions in neuronal intermediate filament inclusion disease. Author URL.
Forman MS, Mackenzie IR, Markesbery WR, Swanson E, Cairns NJ, Boyer PJ, Jhaveri BS, Karlawish JH, McKeel DW, Pestronk A, et al (2005). Novel ubiquitin brain pathology in frontotemporal dementia with inclusion body myopathy and Paget's disease. Author URL.
Schüssel K, Leutner S, Cairns NJ, Czech C, Pradier L, Müller WE, Eckert A (2004). Impact of gender on oxidative stress parameters in Alzheimer's disease. Author URL.
Momeni P, Cairns N, Perry R, Jaros E, Singleton AB, Hardy J (2004). Molecular study of dementia with neurofilament inclusions. Author URL.
Cairns NJ, Zhukareva V, Uryu K, Bigio E, Makenzie IR, Geaing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, et al (2004). α-internexin is present in the hallmark lesions of neuronal intermediate filament inclusion disease. Author URL.
Schüssel K, Leutner S, Cairns NJ, Czech C, Pradier L, Müller WE, Eckert A (2003). Antioxidative defence capacity in sporadic Alzheimer's disease and in transgenic mice overexpressing amyloid-beta. Author URL.
Cairns NJ, Perry R, Jaros E, Lowe J, Skellerud K, Duckaerts C, Cruz-Sanchez F, Lantos P (2002). A new dementia: Neurofilament inclusion body dementia. Author URL.
Kim SH, Lubec G, Fountoulakis M, Hoffmann-La Roche F, Cairns NJ, Bank B (2002). Human brain nucleoside diphosphate kinase-A is decreased in Alzheimer's disease and Down syndrome. Author URL.
Lantos PL, Khan N, Cairns NJ, Janssen JC, Morris HR, Rossor MN (2001). The neuropathological classification of familial frontotemporal dementia. Author URL.
Kovacs T, Cairns NJ, Lantos PL (2000). Cortical olfactory centres in Alzheimer's disease and ageing. Author URL.
Cairns NJ, Murray A, Holmes C, Lantos PL (2000). Neuropathological correlates of psychotic symptoms in Alzheimer's disease. Author URL.
Lantos PL, Reyesz T, King A, Cairns NJ, Morris HR, Janssen J, Rossor MN (2000). Phenotypic variations in frontotemporal dementia caused by exon 10+16 splice site tau mutation. Author URL.
Valerio A, Ferrario M, Paoletti C, Paterlini M, Benarese M, Cairns NJ, Pizzi M, Spano PF (2000). Spinal cord mGlu1 receptors: Possible target for amyotrophic lateral sclerosis therapy. Author URL.
Greber S, Lubec G, Cairns N, Fountoulakis M (1999). Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease. Abstract.
Lantos PL, Cairns NJ, Harvey R, Rossor MN (1999). Familial Alzheimer's disease and Lewy body pathology. Author URL.
Langen H, Berndt P, Röder D, Cairns N, Lubec G, Fountoulakis M (1999). Two-dimensional map of human brain proteins. Abstract.
Fukutani Y, Cairns NJ, Rossor MN, Isaki K, Lantos PL (1997). Cerebellar pathology in sporadic and familial Alzheimer's disease: a morphometric investigation. Author URL.
Eckert GP, Maras A, Gattaz WF, Cairns NJ, Muller WE (1997). Cholesterol modulates beta-amyloid effects on human brain membranes - Specific changes in Alzheimer's disease. Author URL.
Seidl R, Cairns N, Lubec G (1997). Evidence against increased glycoxidation in Alzheimer disease.
Kovacs T, Cairns NJ, Lantos PL (1997). Pathology of the olfactory bulb in Alzheimer's disease. Author URL.
Lantos PL, Spargo E, Cairns NJ, Papp MI (1996). The cellular and molecular pathology of multiple system atrophy: Recent developments. Author URL.
CAIRNS NJ, CHADWICK A, BURNS A, LEVY R, LANTOS PL (1994). BETA-AMYLOID LOAD IN THE NEOCORTEX OF ELDERLY ALZHEIMERS-DISEASE PATIENTS. Author URL.
CAIRNS NJ (1993). BETA-A4 AMYLOIDOSIS IN FAMILIAL ALZHEIMERS-DISEASE WITH THE MUTATION IN CODON 717 OF THE BETA-A4 AMYLOID PRECURSOR PROTEIN GENE. Author URL.
External Engagement and Impact
Awards
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Moore Award, Association of American Neuropathologists.
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Fellow, Royal College of Pathologists of the United Kingdom.
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Top 100 Investigators in Alzheimer’s Disease Research. J. Alzheimer’s Disease 2009; 16: 451–465.
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Dorismae and Harvey Friedman Research on Aging Award.
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Highly cited researcher in top 1% of papers in neuroscience and behaviour. Web of Science 2020.
Committee/panel activities
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NIH Neurobiobank Brain and Tissue Repository 2019, Review Panel. National Institutes of Health, USA.
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Alzheimer's Disease and Its Related Dementias 2019, Review Panel. National Institutes of Health.
Editorial responsibilities
- Brain Pathology
Invited lectures
- Neuropathologic heterogeneity in autosomal dominant and late-onset Alzheimer disease. Nineteenth International Congress of Neuropathology, Tokyo, Japan.
- The first NINDS/NBIB consensus meeting to define neuropathologic criteria for the diagnosis of chronic traumatic encephalopathy. Nineteenth International Congress of Neuropathology, Tokyo, Japan.
