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Professor Noel Morgan

Professor Noel Morgan

Vice-Dean: Research (Interim), Professor of Endocrine Pharmacology; Director - Institute of Biomedical & Clinical Science

01392 408300

RILD Building 4.10

Professor Morgan has a background in cellular pharmacology and his research career has focussed principally on the (patho)physiology of the pancreatic beta-cell biology in the context of both type 1 and type 2 diabetes. Within the University of Exeter Medical School he leads a team studying the regulation of beta-cell function and viability with the aim to understand how dysfunction and loss of viability lead to clinical disease. His research team has made important recent contributions to the understanding of insulitis (a process of immune-mediated attack) in human pancreas and to the role of a group of common viruses (enteroviruses) as potential mediaotrs of beta-cell loss in type 1 diabetes. He also serves as Director of the Institute of Biomedical and Clinical Science and assists in developing the strategic vision of the Institute as well as the achievement of these goals. This involves resource allocation, strategic planning, recruitment, undertaking staff appraisals and facilitation of the career aspirations of staff at all levels. He is also Director of Postgraduate Research within the Medical School and, in this capacity, chairs the School's Research Degrees committee. He has oversight of the approval and appointment of postgraduate research students as well as the monitoring of their progress, their skill development portfolio and ultimate thesis completion and examination.

Broad research specialisms

His team's research specialisms include the monitoring and assessment of cell function and viability using in vitro approaches; the manipulation of intracellular signalling pathways using both pharmacological and molecular biological approaches; and the application of immunological methods to understand disease pathology in relevant histological samples.

Qualifications

  • B.Sc. (Hons)
  • Ph.D.

Career

Noel Morgan began his research career studying islet biology at University of Leicester and then undertook postdoctoral work on the hormonal control of liver glycogenolysis at Vanderbilt University (Nashville, TN). He subsequently developed an independent research programme in islet biology while on the faculty of Keele University (UK). Noel was awarded the inaugural Albert E. Renold Fellowship of EASD in 1990 to work in the laboratory of Robert J Lefkowitz (2012 Nobel laureate) at Duke University, Durham, NC studying adrenoceptor signalling in beta-cells. He was appointed to a Personal Chair at Keele University in 1993 and moved to University of Exeter, in 2002, as Professor of Endocrine Pharmacology. At Exeter, his group has pursued parallel studies on signaling mechanisms regulating β-cell function and viability as well as factors that underlie the loss of β-cells in type 1 diabetes. The latter has been sustained by a long and productive collaboration with Prof Alan Foulis and, together with Dr Sarah Richardson, the team has contributed to the understanding of insulitis in humans and to the role of enteroviruses as potential mediators of islet autoimmunity.

 

Secretary contact details: Nikki Archer, +44 (0) 1392 408215

Links

Research

Research interests

Professor Morgan's team has research interests which centre around the mechanisms that lead to beta-cell dysfunction and death in both type 1 and type 2 diabetes. Their work in type 1 diabetes makes use of a unique cohort of pancreas samples recovered from patients who died soon after diagnosis, to study the natural history of the disease. They are investigating the immune cell composition of the infiltrate that is associated with beta-cell loss (known as “insulitis”) and are also studying the possible involvement of an enteroviral infection as a mediator of islet autoimmunty. The anti-viral mechanisms that become activated in beta-cells during such infections are a particular focus of investigation.

In addition, they employ cell culture models to study the role of fatty acids as regulators of beta-cell viability. Patients with type 2 diabetes often have elevated levels of long chain free fatty acids and these can cause beta-cell death. Their work has revealed that the effects of such molecules on viability are influenced greatly by the chain length and degree of unsaturation of the fatty acid molecules. Indeed, it is evident that long chain saturated species are frequently cytotoxic whereas the equivalent long chain unsaturates (both mono- and poly-) are well tolerated and can even be cytoprotective. They are currently studying the mechanisms involved.

A third area of interest is the signalling pathways used by anti-inflammatory cytokines, such as interleukin-4 and interleukin-13 to promote beta-cell viability. These molecules regulate the activity of a family of transcription factors (STATs) and they are examining exactly how various STAT isoforms become activated and the mechanisms that then lead to improved viability. In parallel, they are also studying the pro-apoptotic actions of other STAT family members to understand how these proteins cause differential effects on beta-cell viability.

Professor Morgan gives an overview of his research in the video below, in a joint presentation with Kyle Wedgwood, filmed at the Living Systems Institute Symposium 2016.

Research projects

  • Beta-cell enteroviral infection and the progression of type 1 diabetes in humans
  • Role of pathogen recognition receptors and anti-viral response pathways in the response of islets cells to enteroviral infection
  • Immune cell subsets as mediators of the selective demise of beta-cells in human type 1 diabetes
  • Factors influencing the uptake and disposition of long chain fatty acids in pancreatic beta-cells
  • Mechanisms involved in the cytoprotective actions of unsaturated fatty acids in beta-cells
  • The role of STAT molecules as regulators of beta-cell viability during exposure to pro- and anti-inflammatory cytokines

Grants/Funding

  • 2010-2013 - Diabetes Research & Wellness Foundation. Sponsor for Non-Clinical Research Fellowship award (Dr SJ Richardson). Beta cell responses to enteroviral infection in Type 1 diabetes. £165000.
  • 2010-1025 - EU Framework 7. Persistent virus infection as a cause of pathogenic inflammation in type 1 diabetes - an innovative research program of biobanks and expertise. 6 million Euro. (350000 Euro to University of Exeter).
  • 2012-2015 - JDRF. The role of viruses in type 1 diabetes (nPOD virus workgroup). $3.5 million ($250000 to University of Exeter)
  • 2013-2016 - Diabetes UK. Subcellular disposition of fatty acids in beta cells revealed by non-linear microscopy: insights into mechanisms of beta-cell lipotoxicity. £145000.

Key publications | Publications by category | Publications by year

Key publications


Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011). Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia, 54(9), 2417-2420. Abstract.  Author URL.  Full text.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010). Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia, 53, 2020-2028. Full text.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009). Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol, 155(2), 173-181. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia, 52(6), 1143-1151. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Wagner FF, Lundh M, Kaya T, McCarren P, Zhang Y-L, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, et al (2016). An Isochemogenic Set of Inhibitors to Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol, 11(2), 363-374. Abstract.  Author URL.
Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG (2016). Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes. Diabetes, 65(5), 1362-1369. Abstract.  Author URL.  Full text.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.  Full text.
Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, et al (2016). Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. Journal of Clinical Virology, 77, 21-28. Full text.
Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, et al (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes, 64(5), 1682-1687. Abstract.  Author URL.  Full text.
Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL (2015). Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells. Elife, 4 Abstract.  Author URL.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia Abstract.  Full text.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.
Flanagan SE, Haapaniemi E, Russell MA, Caswell R, Lango Allen H, De Franco E, McDonald TJ, Rajala H, Ramelius A, Barton J, et al (2014). Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet, 46(8), 812-814. Abstract.  Author URL.  Full text.
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2014). Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes, 63(11), 3835-3845. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]. Diabetologia, 57(3), 647-649. Author URL.  Full text.
Morgan NG, Richardson SJ (2014). Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?. Trends Endocrinol Metab, 25(12), 611-619. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.  Full text.
Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG (2014). GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia, 57(6), 1182-1191. Abstract.  Author URL.  Full text.
Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G (2014). Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway. Journal of Medical Virology, 86(8), 1402-1411. Abstract.
Morgan NG, Leete P, Foulis AK, Richardson SJ (2014). Islet inflammation in human type 1 diabetes mellitus. IUBMB Life, 66(11), 723-734. Abstract.  Author URL.  Full text.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus. Endocr Pathol, 25(1), 80-92. Abstract.  Author URL.  Full text.
Bjursell M, Xu X, Admyre T, Böttcher G, Lundin S, Nilsson R, Stone VM, Morgan NG, Lam YY, Storlien LH, et al (2014). The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120. PLoS One, 9(12). Abstract.  Author URL.
Russell MA, Morgan NG (2014). The impact of anti-inflammatory cytokines on the pancreatic β-cell. Islets, 6(3). Abstract.  Author URL.  Full text.
Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013). Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia, 56(1), 185-193. Abstract.  Full text.
Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M (2013). Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon Treated Primary Human Pancreatic Islets. Journal of virology
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC, et al (2013). Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia, 56(5), 1068-1077. Abstract.
Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ, Morgan NG, Eizirik DL (2012). Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia, 55(9), 2417-2420. Abstract.
Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, et al (2012). Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia, 55(9), 2421-2431. Abstract.
Stone VM, Dhayal S, Smith DM, Lenaghan C, Brocklehurst KJ, Morgan NG (2012). The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. Br J Pharmacol, 165(8), 2758-2770. Abstract.  Author URL.
Keane DC, Takahashi HK, Dhayal S, Morgan NG, Curi R, Newsholme P (2011). Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clin Sci (Lond), 120(5), 195-206. Abstract.  Author URL.
Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.
Reers C, Hauge-Evans AC, Morgan NG, Willcox A, Persaud SJ, Jones PM (2011). Downregulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration. Islets, 3(3), 80-88. Abstract.
Johnstone KA, Diakogiannaki E, Dhayal S, Morgan NG, Harries LW (2011). Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid. JOP, 12(1), 6-10. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011). Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia, 54(9), 2417-2420. Abstract.  Author URL.  Full text.
Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2011). Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol, 33(1), 9-21. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells. Br J Pharmacol, 162(6), 1340-1350. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Structure-activity relationships influencing lipid-induced changes in eIF2α phosphorylation and cell viability in BRIN-BD11 cells. FEBS Lett, 585(14), 2243-2248. Abstract.  Author URL.
Lidder P, Flanagan D, Fleming S, Russell M, Morgan N, Wheatley T, Rahamin J, Shaw S, Lewis S (2010). Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr, 103(11), 1635-1641. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010). Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia, 53, 2020-2028. Full text.
Russell MA, Morgan NG (2010). Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells. Islets, 2(6), 374-382. Abstract.  Author URL.
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A, Kelly C, King A, et al (2010). Pseudoislets as primary islet replacements for research: Report on a symposium at King's College London, London UK. Islets, 2(4), 236-239. Abstract.
Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, Del Castillo G, et al (2010). Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 107(7), 3105-3110. Abstract.
Dhayal S, Morgan NG (2010). The significance of GPR119 agonists as a future treatment for type 2 diabetes. Drug News Perspect, 23(7), 418-424. Abstract.  Author URL.
Morgan NG, Dhayal S (2010). Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell. Prostaglandins Leukot Essent Fatty Acids, 82(4-6), 231-236. Abstract.  Author URL.
Richardson SJ, Willcox A, Hilton DA, Tauriainen S, Hyoty H, Bone AJ, Foulis AK, Morgan NG (2010). Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue. J Clin Virol, 49(3), 180-185. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009). Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol, 155(2), 173-181. Abstract.  Author URL.
Morgan NG (2009). Fatty acids and beta-cell toxicity. Curr Opin Clin Nutr Metab Care, 12(2), 117-122. Abstract.  Author URL.
Morgan NG, Dhayal S (2009). G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem Pharmacol, 78(12), 1419-1427. Abstract.  Author URL.
Kaminski A, Welters HJ, Kaminski ER, Morgan NG (2009). Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep, 30(3), 169-175. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Islet-associated macrophages in type 2 diabetes. Diabetologia, 52(8), 1686-1688. Author URL.
Morgan NG, Diakogiannaki E, Russell MA (2009). The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol, 560, 53-64. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia, 52(6), 1143-1151. Abstract.  Author URL.  Full text.
Diakogiannaki E, Welters HJ, Morgan NG (2008). Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol, 197(3), 553-563. Abstract.  Author URL.
Farn RD, Morgan NG, Ramsden CA (2008). Preparation of analogues of efaroxan and KU14R as potential imidazoline receptor subtype 3 ligands. Journal of Heterocyclic Chemistry, 45(3), 887-896. Abstract.
Ravanan R, Wong SF, Morgan NG, Mathieson PW, Smith RM (2007). Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse. Clin Exp Immunol, 148(2), 368-372. Abstract.  Author URL.
Newsholme P, Keane D, Welters HJ, Morgan NG (2007). Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clin Sci (Lond), 112(1), 27-42. Abstract.  Author URL.
Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG (2007). Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol, 194(2), 283-291. Abstract.  Author URL.
Kaminski A, Kaminski ER, Morgan NG (2007). Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines. Clin Exp Immunol, 148(3), 583-588. Abstract.  Author URL.
Diakogiannaki E, Welters HJ, Eickelmann P, Morgan NG (2007). The unsaturated fatty acid, palmitoleate, inhibits the expression of the ER-stress-associated pro-apoptotic factor CHOP-10/GADD153 in pancreatic beta-cells. DIABETIC MEDICINE, 24, 10-11. Author URL.
Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM (2006). A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells. Diabetes, 55(11), 3075-3082. Abstract.  Author URL.
Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, et al (2006). Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells. J Endocrinol, 190(1), 171-181. Abstract.  Author URL.
NMorgan, Diakogiannaki E, Mordue J, Welters H (2006). Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic b-cells exposed to pamitate. APOPTOSIS, 11(7), 1231-1238.
Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT (2006). Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet, 15(14), 2216-2224. Abstract.  Author URL.
Taylor JP, Jackson DA, Morgan NG, Chan SLF (2006). Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. Biochem Biophys Res Commun, 349(2), 809-815. Abstract.  Author URL.
Welters HJ, Smith SA, Tadayyon M, Scarpello JHB, Morgan NG (2004). Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. J Mol Endocrinol, 32(1), 227-235. Abstract.  Author URL.
Welters HJ, McBain SC, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Expression and functional activity of PPARgamma in pancreatic beta cells. Br J Pharmacol, 142(7), 1162-1170. Abstract.  Author URL.
Prell GD, Martinelli GP, Holstein GR, Matulic-Adamic J, Watanabe KA, Chan SLF, Morgan NG, Haxhiu MA, Ernsberger P (2004). Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A, 101(37), 13677-13682. Abstract.  Author URL.
Kaminski A, Gao H, Morgan NG (2004). Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells. FEBS Lett, 559(1-3), 118-124. Abstract.  Author URL.
Welters HJ, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett, 560(1-3), 103-108. Abstract.  Author URL.
Yang Y, Zhang S, Jones G, Morgan N, El Haj AJ (2004). Phosphorylcholine-containing polymers for use in cell encapsulation. Artif Cells Blood Substit Immobil Biotechnol, 32(1), 91-104. Abstract.  Author URL.
Squires PE, Hills CE, Rogers GJ, Garland P, Farley SR, Morgan NG (2004). The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells. Eur J Pharmacol, 501(1-3), 31-39. Abstract.  Author URL.
Cooper EJ, Hudson AL, Parker CA, Morgan NG (2003). Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol, 482(1-3), 189-196. Abstract.  Author URL.
Gao H, Mourtada M, Morgan NG (2003). Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells. JOP, 4(3), 117-124. Abstract.  Author URL.
McBain SC, Morgan NG (2003). Functional effects of expression of wolframin-antisense transcripts in BRIN-BD11 beta-cells. Biochem Biophys Res Commun, 307(3), 684-688. Abstract.  Author URL.
Elliott J, Scarpello JHB, Morgan NG (2002). Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells. J Endocrinol, 172(1), 137-143. Abstract.  Author URL.
Kowluru A, Morgan NG (2002). GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell. Biochem Pharmacol, 63(6), 1027-1035. Abstract.  Author URL.
Chan SLF, Monks LK, Gao H, Deaville P, Morgan NG (2002). Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. Br J Pharmacol, 136(1), 31-36. Abstract.  Author URL.
Chan SL, Mourtada M, Morgan NG (2001). Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. Diabetes, 50(2), 340-347. Abstract.  Author URL.
Elliott J, Scarpello JH, Morgan NG (2001). Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic beta-cell line, RINm5F. Br J Pharmacol, 132(1), 119-126. Abstract.  Author URL.
Morgan NG, Chan SL (2001). Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues?. Curr Pharm Des, 7(14), 1413-1431. Abstract.  Author URL.
Trigwell SM, Radford PM, Page SR, Loweth AC, James RF, Morgan NG, Todd I (2001). Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus. Clin Exp Immunol, 126(2), 242-249. Abstract.  Author URL.
Clews J, Morgan NG, Ramsden CA (2001). Preparation of novel 2-(benzo[b]furan-2-yl)-1H-imidazolines for photoaffinity labelling and affinity isolation of imidazoline binding proteins. JOURNAL OF HETEROCYCLIC CHEMISTRY, 38(2), 519-521. Author URL.
Clews J, Morgan NG, Ramsden CA (2001). Preparation of the I-3 imidazoline receptor antagonist KU14R and related 2,3-dihydrobenzo[b]furan derivatives. SYNTHESIS-STUTTGART(10), 1546-1550. Author URL.
Loweth AC, Watts K, McBain SC, Williams GT, Scarpello JH, Morgan NG (2000). Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans. Diabetes Obes Metab, 2(1), 57-60. Abstract.  Author URL.
Mourtada M, Elliott J, Smith SA, Morgan NG (2000). Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells. Naunyn Schmiedebergs Arch Pharmacol, 361(2), 146-154. Abstract.  Author URL.
Monks LK, Cosgrove KE, Dunne MJ, Ramsden CA, Morgan NG, Chan SL (1999). Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as a ligand. FEBS Lett, 447(1), 61-64. Abstract.  Author URL.
Pizzinat N, Chan SL, Remaury A, Morgan NG, Parini A (1999). Characterization of monoamine oxidase isoforms in human islets of Langerhans. Life Sci, 65(4), 441-448. Abstract.  Author URL.
Pelé-Tounian A, Chan SL, Rondu F, Le Bihan G, Giroix MH, Lamouri A, Touboul E, Pfeiffer B, Manechez D, Renard P, et al (1999). Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats. Eur J Pharmacol, 377(1), 81-87. Abstract.  Author URL.
Parker CA, Hudson AL, Nutt DJ, Dillon MP, Eglen RM, Chan SL, Morgan NG, Crosby J (1999). Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues. Eur J Pharmacol, 378(2), 213-221. Abstract.  Author URL.
Morgan NG (1999). Imidazoline receptors: new targets for antihyperglycaemic drugs. Expert Opin Investig Drugs, 8(5), 575-584. Abstract.  Author URL.
Mourtada M, Chan SL, Smith SA, Morgan NG (1999). Multiple effector pathways regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets. Br J Pharmacol, 127(5), 1279-1287. Abstract.  Author URL.
Eglen RM, Hudson AL, Kendall DA, Nutt DJ, Morgan NG, Wilson VG, Dillon MP (1998). 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. Trends Pharmacol Sci, 19(9), 381-390. Abstract.  Author URL.
El-Mansoury AM, Morgan NG (1998). Activation of protein kinase C modulates alpha2-adrenergic signalling in rat pancreatic islets. Cell Signal, 10(9), 637-643. Abstract.  Author URL.
Chan SL, Pallett AL, Clews J, Ramsden CA, Chapman JC, Kane C, Dunne MJ, Morgan NG (1998). Characterisation of new efaroxan derivatives for use in purification of imidazoline-binding sites. Eur J Pharmacol, 355(1), 67-76. Abstract.  Author URL.
Mourtada M, Smith SA, Morgan NG (1998). Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans. Eur J Pharmacol, 350(2-3), 251-258. Abstract.  Author URL.
Loweth AC, Williams GT, James RF, Scarpello JH, Morgan NG (1998). Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes, 47(5), 727-732. Abstract.  Author URL.
Loweth AC, Morgan NG (1998). Methods for the study of NO-induced apoptosis in cultured cells. Methods Mol Biol, 100, 311-320. Author URL.
Chan SL, Morgan NG (1998). Sigma receptor ligands and imidazoline secretagogues mediate their insulin secretory effects by activating distinct receptor systems in isolated islets. Eur J Pharmacol, 350(2-3), 267-272. Abstract.  Author URL.
Chan SL, Pallett AL, Morgan NG (1997). Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch Pharmacol, 356(6), 763-768. Abstract.  Author URL.
Chan SL, Perrett CW, Morgan NG (1997). Differential expression of alpha 2-adrenoceptor subtypes in purified rat pancreatic islet A- and B-cells. Cell Signal, 9(1), 71-78. Abstract.  Author URL.
Loweth AC, Williams GT, Scarpello JH, Morgan NG (1997). Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15. FEBS Lett, 400(3), 285-288. Abstract.  Author URL.
Chan SL, Pallett AL, Clews J, Ramsden CA, Morgan NG (1997). Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with sigma receptors. Eur J Pharmacol, 323(2-3), 241-244. Abstract.  Author URL.
Mourtada M, Smith SA, Morgan NG (1997). Insulin secretagogues with an imidazoline structure inhibit arginine-induced secretion from isolated glucagon secretion from isolated rat islets of Langerhans. Biochem Biophys Res Commun, 236(1), 162-166. Abstract.  Author URL.
Mourtada M, Brown CA, Smith SA, Piercy V, Chan SL, Morgan NG (1997). Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion. Br J Pharmacol, 121(4), 799-805. Abstract.  Author URL.
Di Matteo MA, Loweth AC, Thomas S, Mabley JG, Morgan NG, Thorpe JR, Green IC (1997). Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms. Apoptosis, 2(2), 164-177. Abstract.  Author URL.
Chan SL, Atlas D, James RF, Morgan NG (1997). The effect of the putative endogenous imidazoline receptor ligand, clonidine-displacing substance, on insulin secretion from rat and human islets of Langerhans. Br J Pharmacol, 120(5), 926-932. Abstract.  Author URL.
Loweth AC, Scarpello JH, Morgan NG (1996). A specific inhibitor of cytosolic phospholipase A2 activity, AACOCF3, inhibits glucose-induced insulin secretion from isolated rat islets. Biochem Biophys Res Commun, 218(2), 423-427. Abstract.  Author URL.
Lacey RJ, Chan SL, Cable HC, James RF, Perrett CW, Scarpello JH, Morgan NG (1996). Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans. J Endocrinol, 148(3), 531-543. Abstract.  Author URL.
Loweth AC, Williams GT, Scarpello JH, Morgan NG (1996). Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic beta-cells. Exp Cell Res, 229(1), 69-76. Abstract.  Author URL.
Morgan NG, Pallett AL, Mourtada M, Chan SLF, Clews J, Ramsden CA (1996). Synthesis and characterisation of KU14R a novel antagonist of the pancreatic islet imidazoline binding site. DIABETOLOGIA, 39, 456-456. Author URL.
Cable HC, el-Mansoury A, Morgan NG (1995). Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells. Biochem J, 307 ( Pt 1), 169-174. Abstract.  Author URL.
Morgan NG, Chan SL, Brown CA, Tsoli E (1995). Characterization of the imidazoline binding site involved in regulation of insulin secretion. Ann N Y Acad Sci, 763, 361-373. Author URL.
LOWETH AC, SCARPELLO JHB, MORGAN NG (1995). PHOSPHOLIPASE A(2) EXPRESSION IN HUMAN AND RODENT INSULIN-SECRETING CELLS (VOL 112, PG 177, 1995). MOLECULAR AND CELLULAR ENDOCRINOLOGY, 114(1-2), 227-228. Author URL.
Chan SL, Brown CA, Scarpello KE, Morgan NG (1995). Pancreatic beta-cells express an imidazoline binding site that is distinct from I1 and I2 sites. Ann N Y Acad Sci, 763, 153-156. Author URL.
Loweth AC, Scarpello JH, Morgan NG (1995). Phospholipase A2 expression in human and rodent insulin-secreting cells. Mol Cell Endocrinol, 112(2), 177-183. Abstract.  Author URL.
Tsoli E, Chan SL, Morgan NG (1995). The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans. Eur J Pharmacol, 284(1-2), 199-203. Abstract.  Author URL.
Loweth AC, Scarpello JH, Morgan NG (1994). A comparison of cytosolic phospholipase A2 expression in human islets of Langerhans and rodent insulin-secreting cells. Biochem Soc Trans, 22(4). Author URL.
Chan SL, Brown CA, Scarpello KE, Morgan NG (1994). The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites. Br J Pharmacol, 112(4), 1065-1070. Abstract.  Author URL.
Morgan NG, Cable HC, Newcombe NR, Williams GT (1994). Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis. Biosci Rep, 14(5), 243-250. Abstract.  Author URL.
Brown CA, Chan SL, Stillings MR, Smith SA, Morgan NG (1993). Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080. Br J Pharmacol, 110(3), 1017-1022. Abstract.  Author URL.
Lacey RJ, Cable HC, James RF, London NJ, Scarpello JH, Morgan NG (1993). Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans. J Endocrinol, 138(3), 555-563. Abstract.  Author URL.
Brown CA, Morgan NG (1993). Control of insulin secretion by imidazolines in rat pancreatic islets. Biochem Soc Trans, 21(2). Author URL.
Brown CA, Loweth AC, Smith SA, Morgan NG (1993). Stimulation of insulin secretion by imidazoline compounds is not due to interaction with non-adrenoceptor idazoxan binding sites. Br J Pharmacol, 108(2), 312-317. Abstract.  Author URL.
Chan SL, Brown CA, Morgan NG (1993). Stimulation of insulin secretion by the imidazoline alpha 2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site. Eur J Pharmacol, 230(3), 375-378. Abstract.  Author URL.
Lacey RJ, Scarpello JH, Morgan NG (1992). Evidence that the presence of arginine can lead to overestimation of glucagon levels measured by radioimmunoassay. Clin Chim Acta, 210(3), 211-219. Author URL.
Berrow NS, Milligan G, Morgan NG (1992). Immunological characterization of the guanine-nucleotide binding proteins Gi and Go in rat islets of Langerhans. J Mol Endocrinol, 8(2), 103-108. Abstract.  Author URL.
Berrow NS, Hurst RD, Chan SL, Morgan NG (1992). Immunoprecipitation of a pertussis toxin substrate of the G(o) family from rat islets of Langerhans. Biosci Rep, 12(2), 95-100. Abstract.  Author URL.
Chan SL, Stillings MR, Morgan NG (1991). Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128. Biochem Biophys Res Commun, 176(3), 1545-1551. Abstract.  Author URL.
Lacey RJ, Berrow NS, Scarpello JH, Morgan NG (1991). Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat. Br J Pharmacol, 103(3), 1824-1828. Abstract.  Author URL.
Chan SL, Dunne MJ, Stillings MR, Morgan NG (1991). The alpha 2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells. Eur J Pharmacol, 204(1), 41-48. Abstract.  Author URL.
Lacey RJ, Berrow NS, London NJ, Lake SP, James RF, Scarpello JH, Morgan NG (1990). Differential effects of beta-adrenergic agonists on insulin secretion from pancreatic islets isolated from rat and man. J Mol Endocrinol, 5(1), 49-54. Abstract.  Author URL.
Hurst RD, Morgan NG (1990). Evidence for differential effects of noradrenaline and somatostatin on intracellular messenger systems in rat islets of Langerhans. J Mol Endocrinol, 4(3), 231-237. Abstract.  Author URL.
Berrow NS, Morgan NG (1990). Evidence for the presence of low molecular mass GTP-binding proteins in rat islets of Langerhans. Biochem Soc Trans, 18(3), 485-486. Author URL.
Chan SL, Morgan NG (1990). Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels. Eur J Pharmacol, 176(1), 97-101. Abstract.  Author URL.
Morgan NG, Hurst RD, Berrow NS, Montague W (1989). Calcium handling by stimulated islets of Langerhans. Biochem Soc Trans, 17(1), 64-66. Author URL.
Hurst RD, Chan SL, Morgan NG (1989). Effects of benextramine on the adrenergic inhibition of insulin secretion in isolated rat pancreatic islets. J Mol Endocrinol, 2(2), 99-105. Abstract.  Author URL.
Chan SL, Morgan NG (1989). Effects of phenoxybenzamine on insulin secretion from isolated rat islets of Langerhans. Biosci Rep, 9(2), 223-230. Abstract.  Author URL.
Hurst RD, Morgan NG (1989). Intracellular events responsible for the inhibition of insulin secretion by somatostatin. Biochem Soc Trans, 17(6), 1085-1086. Author URL.
Morgan NG, Hurst RD (1988). Dissociation between intracellular calcium mobilization and insulin secretion in isolated rat islets of Langerhans. FEBS Lett, 227(2), 153-156. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1987). Mechanisms involved in intracellular calcium mobilization in isolated rat islets of Langerhans. Biochem J, 244(3), 669-674. Abstract.  Author URL.
MORGAN NG (1987). REGULATION OF INSULIN-SECRETION BY ALPHA-2-ADRENERGIC AGONISTS. TRENDS IN PHARMACOLOGICAL SCIENCES, 8(10), 369-370. Author URL.
Montague W, Morgan NG, Rumford GM, Prince CA (1985). Effect of glucose on polyphosphoinositide metabolism in isolated rat islets of Langerhans. Biochem J, 227(2), 483-489. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Effects of noradrenaline on 45Ca2+ efflux from isolated rat islets of Langerhans. Biosci Rep, 5(12), 1053-1060. Abstract.  Author URL.
Morgan NG, Short CD, Rumford GM, Montague W (1985). Effects of the calcium-channel agonist CGP 28392 on insulin secretion from isolated rat islets of Langerhans. Biochem J, 231(3), 629-634. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Studies on the mechanism by which melittin stimulates insulin secretion from isolated rat islets of Langerhans. Biochim Biophys Acta, 845(3), 526-532. Abstract.  Author URL.
Morgan NG, Montague W (1985). Studies on the mechanism of inhibition of glucose-stimulated insulin secretion by noradrenaline in rat islets of Langerhans. Biochem J, 226(2), 571-576. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Studies on the role of inositol trisphosphate in the regulation of insulin secretion from isolated rat islets of Langerhans. Biochem J, 228(3), 713-718. Abstract.  Author URL.
Morgan NG, Charest R, Blackmore PF, Exton JH (1984). Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism. Proc Natl Acad Sci U S A, 81(13), 4208-4212. Abstract.  Author URL.
Morgan NG, Montague W (1984). Stimulation of insulin secretion from isolated rat islets of Langerhans by melittin. Biosci Rep, 4(8), 665-671. Abstract.  Author URL.
Morgan NG, Blackmore PF, Exton JH (1983). Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats. J Biol Chem, 258(8), 5103-5109. Abstract.  Author URL.
Morgan NG, Exton JH, Blackmore PF (1983). Angiotensin II inhibits hepatic cAMP accumulation induced by glucagon and epinephrine and their metabolic effects. FEBS Lett, 153(1), 77-80. Abstract.  Author URL.
Morgan NG, Waynick LE, Exton JH (1983). Characterisation of the alpha 1-adrenergic control of hepatic cAMP in male rats. Eur J Pharmacol, 96(1-2), 1-10. Abstract.  Author URL.
Morgan NG, Blackmore PF, Exton JH (1983). Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP. J Biol Chem, 258(8), 5110-5116. Abstract.  Author URL.
Morgan NG, Shipp CC, Exton JH (1983). Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin. FEBS Lett, 163(2), 277-281. Abstract.  Author URL.
Morgan NG, Shuman EA, Exton JH, Blackmore PF (1982). Stimulation of hepatic glycogenolysis by alpha 1- and beta 2-adrenergic agonists. Evidence against short term agonist-induced desensitization of the responses. J Biol Chem, 257(23), 13907-13910. Abstract.  Author URL.
Morgan NG, Montague W (1982). Studies on the interaction of staphylococcal delta-haemolysin with isolated islets of Langerhans. Biochem J, 204(1), 111-125. Abstract.  Author URL.
Morgan NG, Fitzhugh AJ, Montague W (1981). The effect of staphylococcal delta-haemolysin on the secretory activity of the pancreatic beta-cell. Biosci Rep, 1(2), 135-140. Abstract.  Author URL.
Ducommun Y, Morgan NG, Montague W (1979). Subcellular distribution of protein kinase activities in mammalian islets of Langerhans [proceedings]. Biochem Soc Trans, 7(5), 913-915. Author URL.

Publications by year


2016

Wagner FF, Lundh M, Kaya T, McCarren P, Zhang Y-L, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, et al (2016). An Isochemogenic Set of Inhibitors to Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol, 11(2), 363-374. Abstract.  Author URL.
Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG (2016). Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes. Diabetes, 65(5), 1362-1369. Abstract.  Author URL.  Full text.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.  Full text.
Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, et al (2016). Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. Journal of Clinical Virology, 77, 21-28. Full text.

2015

Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, et al (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes, 64(5), 1682-1687. Abstract.  Author URL.  Full text.
Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL (2015). Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells. Elife, 4 Abstract.  Author URL.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia Abstract.  Full text.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.

2014

Flanagan SE, Haapaniemi E, Russell MA, Caswell R, Lango Allen H, De Franco E, McDonald TJ, Rajala H, Ramelius A, Barton J, et al (2014). Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet, 46(8), 812-814. Abstract.  Author URL.  Full text.
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2014). Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes, 63(11), 3835-3845. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]. Diabetologia, 57(3), 647-649. Author URL.  Full text.
Morgan NG, Richardson SJ (2014). Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?. Trends Endocrinol Metab, 25(12), 611-619. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.  Full text.
Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG (2014). GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia, 57(6), 1182-1191. Abstract.  Author URL.  Full text.
Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine AB, Hyöty H, Morgan NG, Korsgren O, Frisk G (2014). Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway. Journal of Medical Virology, 86(8), 1402-1411. Abstract.
Morgan NG, Leete P, Foulis AK, Richardson SJ (2014). Islet inflammation in human type 1 diabetes mellitus. IUBMB Life, 66(11), 723-734. Abstract.  Author URL.  Full text.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus. Endocr Pathol, 25(1), 80-92. Abstract.  Author URL.  Full text.
Bjursell M, Xu X, Admyre T, Böttcher G, Lundin S, Nilsson R, Stone VM, Morgan NG, Lam YY, Storlien LH, et al (2014). The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120. PLoS One, 9(12). Abstract.  Author URL.
Russell MA, Morgan NG (2014). The impact of anti-inflammatory cytokines on the pancreatic β-cell. Islets, 6(3). Abstract.  Author URL.  Full text.

2013

Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.
Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013). Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia, 56(1), 185-193. Abstract.  Full text.
Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M (2013). Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon Treated Primary Human Pancreatic Islets. Journal of virology
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC, et al (2013). Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia, 56(5), 1068-1077. Abstract.

2012

Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ, Morgan NG, Eizirik DL (2012). Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia, 55(9), 2417-2420. Abstract.
Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, et al (2012). Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia, 55(9), 2421-2431. Abstract.
Stone VM, Dhayal S, Smith DM, Lenaghan C, Brocklehurst KJ, Morgan NG (2012). The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. Br J Pharmacol, 165(8), 2758-2770. Abstract.  Author URL.

2011

Keane DC, Takahashi HK, Dhayal S, Morgan NG, Curi R, Newsholme P (2011). Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clin Sci (Lond), 120(5), 195-206. Abstract.  Author URL.
Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.
Reers C, Hauge-Evans AC, Morgan NG, Willcox A, Persaud SJ, Jones PM (2011). Downregulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration. Islets, 3(3), 80-88. Abstract.
Johnstone KA, Diakogiannaki E, Dhayal S, Morgan NG, Harries LW (2011). Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid. JOP, 12(1), 6-10. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011). Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia, 54(9), 2417-2420. Abstract.  Author URL.  Full text.
Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2011). Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol, 33(1), 9-21. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells. Br J Pharmacol, 162(6), 1340-1350. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Structure-activity relationships influencing lipid-induced changes in eIF2α phosphorylation and cell viability in BRIN-BD11 cells. FEBS Lett, 585(14), 2243-2248. Abstract.  Author URL.

2010

Lidder P, Flanagan D, Fleming S, Russell M, Morgan N, Wheatley T, Rahamin J, Shaw S, Lewis S (2010). Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr, 103(11), 1635-1641. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010). Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia, 53, 2020-2028. Full text.
Russell MA, Morgan NG (2010). Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells. Islets, 2(6), 374-382. Abstract.  Author URL.
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A, Kelly C, King A, et al (2010). Pseudoislets as primary islet replacements for research: Report on a symposium at King's College London, London UK. Islets, 2(4), 236-239. Abstract.
Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, Del Castillo G, et al (2010). Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 107(7), 3105-3110. Abstract.
Dhayal S, Morgan NG (2010). The significance of GPR119 agonists as a future treatment for type 2 diabetes. Drug News Perspect, 23(7), 418-424. Abstract.  Author URL.
Morgan NG, Dhayal S (2010). Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell. Prostaglandins Leukot Essent Fatty Acids, 82(4-6), 231-236. Abstract.  Author URL.
Richardson SJ, Willcox A, Hilton DA, Tauriainen S, Hyoty H, Bone AJ, Foulis AK, Morgan NG (2010). Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue. J Clin Virol, 49(3), 180-185. Abstract.  Author URL.

2009

Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009). Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol, 155(2), 173-181. Abstract.  Author URL.
Morgan NG (2009). Fatty acids and beta-cell toxicity. Curr Opin Clin Nutr Metab Care, 12(2), 117-122. Abstract.  Author URL.
Morgan NG, Dhayal S (2009). G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem Pharmacol, 78(12), 1419-1427. Abstract.  Author URL.
Kaminski A, Welters HJ, Kaminski ER, Morgan NG (2009). Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep, 30(3), 169-175. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Islet-associated macrophages in type 2 diabetes. Diabetologia, 52(8), 1686-1688. Author URL.
Morgan NG, Diakogiannaki E, Russell MA (2009). The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol, 560, 53-64. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia, 52(6), 1143-1151. Abstract.  Author URL.  Full text.

2008

Diakogiannaki E, Welters HJ, Morgan NG (2008). Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol, 197(3), 553-563. Abstract.  Author URL.
Farn RD, Morgan NG, Ramsden CA (2008). Preparation of analogues of efaroxan and KU14R as potential imidazoline receptor subtype 3 ligands. Journal of Heterocyclic Chemistry, 45(3), 887-896. Abstract.

2007

Ravanan R, Wong SF, Morgan NG, Mathieson PW, Smith RM (2007). Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse. Clin Exp Immunol, 148(2), 368-372. Abstract.  Author URL.
Newsholme P, Keane D, Welters HJ, Morgan NG (2007). Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clin Sci (Lond), 112(1), 27-42. Abstract.  Author URL.
Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG (2007). Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol, 194(2), 283-291. Abstract.  Author URL.
Kaminski A, Kaminski ER, Morgan NG (2007). Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines. Clin Exp Immunol, 148(3), 583-588. Abstract.  Author URL.
Diakogiannaki E, Welters HJ, Eickelmann P, Morgan NG (2007). The unsaturated fatty acid, palmitoleate, inhibits the expression of the ER-stress-associated pro-apoptotic factor CHOP-10/GADD153 in pancreatic beta-cells. DIABETIC MEDICINE, 24, 10-11. Author URL.

2006

Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM (2006). A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells. Diabetes, 55(11), 3075-3082. Abstract.  Author URL.
Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, et al (2006). Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells. J Endocrinol, 190(1), 171-181. Abstract.  Author URL.
NMorgan, Diakogiannaki E, Mordue J, Welters H (2006). Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic b-cells exposed to pamitate. APOPTOSIS, 11(7), 1231-1238.
Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT (2006). Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet, 15(14), 2216-2224. Abstract.  Author URL.
Taylor JP, Jackson DA, Morgan NG, Chan SLF (2006). Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. Biochem Biophys Res Commun, 349(2), 809-815. Abstract.  Author URL.

2004

Welters HJ, Smith SA, Tadayyon M, Scarpello JHB, Morgan NG (2004). Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. J Mol Endocrinol, 32(1), 227-235. Abstract.  Author URL.
Welters HJ, McBain SC, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Expression and functional activity of PPARgamma in pancreatic beta cells. Br J Pharmacol, 142(7), 1162-1170. Abstract.  Author URL.
Prell GD, Martinelli GP, Holstein GR, Matulic-Adamic J, Watanabe KA, Chan SLF, Morgan NG, Haxhiu MA, Ernsberger P (2004). Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A, 101(37), 13677-13682. Abstract.  Author URL.
Kaminski A, Gao H, Morgan NG (2004). Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells. FEBS Lett, 559(1-3), 118-124. Abstract.  Author URL.
Welters HJ, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett, 560(1-3), 103-108. Abstract.  Author URL.
Yang Y, Zhang S, Jones G, Morgan N, El Haj AJ (2004). Phosphorylcholine-containing polymers for use in cell encapsulation. Artif Cells Blood Substit Immobil Biotechnol, 32(1), 91-104. Abstract.  Author URL.
Squires PE, Hills CE, Rogers GJ, Garland P, Farley SR, Morgan NG (2004). The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells. Eur J Pharmacol, 501(1-3), 31-39. Abstract.  Author URL.

2003

Cooper EJ, Hudson AL, Parker CA, Morgan NG (2003). Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol, 482(1-3), 189-196. Abstract.  Author URL.
Gao H, Mourtada M, Morgan NG (2003). Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells. JOP, 4(3), 117-124. Abstract.  Author URL.
McBain SC, Morgan NG (2003). Functional effects of expression of wolframin-antisense transcripts in BRIN-BD11 beta-cells. Biochem Biophys Res Commun, 307(3), 684-688. Abstract.  Author URL.

2002

Elliott J, Scarpello JHB, Morgan NG (2002). Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells. J Endocrinol, 172(1), 137-143. Abstract.  Author URL.
Kowluru A, Morgan NG (2002). GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell. Biochem Pharmacol, 63(6), 1027-1035. Abstract.  Author URL.
Chan SLF, Monks LK, Gao H, Deaville P, Morgan NG (2002). Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. Br J Pharmacol, 136(1), 31-36. Abstract.  Author URL.

2001

Chan SL, Mourtada M, Morgan NG (2001). Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. Diabetes, 50(2), 340-347. Abstract.  Author URL.
Elliott J, Scarpello JH, Morgan NG (2001). Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic beta-cell line, RINm5F. Br J Pharmacol, 132(1), 119-126. Abstract.  Author URL.
Morgan NG, Chan SL (2001). Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues?. Curr Pharm Des, 7(14), 1413-1431. Abstract.  Author URL.
Trigwell SM, Radford PM, Page SR, Loweth AC, James RF, Morgan NG, Todd I (2001). Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus. Clin Exp Immunol, 126(2), 242-249. Abstract.  Author URL.
Clews J, Morgan NG, Ramsden CA (2001). Preparation of novel 2-(benzo[b]furan-2-yl)-1H-imidazolines for photoaffinity labelling and affinity isolation of imidazoline binding proteins. JOURNAL OF HETEROCYCLIC CHEMISTRY, 38(2), 519-521. Author URL.
Clews J, Morgan NG, Ramsden CA (2001). Preparation of the I-3 imidazoline receptor antagonist KU14R and related 2,3-dihydrobenzo[b]furan derivatives. SYNTHESIS-STUTTGART(10), 1546-1550. Author URL.

2000

Loweth AC, Watts K, McBain SC, Williams GT, Scarpello JH, Morgan NG (2000). Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans. Diabetes Obes Metab, 2(1), 57-60. Abstract.  Author URL.
Mourtada M, Elliott J, Smith SA, Morgan NG (2000). Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells. Naunyn Schmiedebergs Arch Pharmacol, 361(2), 146-154. Abstract.  Author URL.

1999

Monks LK, Cosgrove KE, Dunne MJ, Ramsden CA, Morgan NG, Chan SL (1999). Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as a ligand. FEBS Lett, 447(1), 61-64. Abstract.  Author URL.
Pizzinat N, Chan SL, Remaury A, Morgan NG, Parini A (1999). Characterization of monoamine oxidase isoforms in human islets of Langerhans. Life Sci, 65(4), 441-448. Abstract.  Author URL.
Pelé-Tounian A, Chan SL, Rondu F, Le Bihan G, Giroix MH, Lamouri A, Touboul E, Pfeiffer B, Manechez D, Renard P, et al (1999). Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats. Eur J Pharmacol, 377(1), 81-87. Abstract.  Author URL.
Parker CA, Hudson AL, Nutt DJ, Dillon MP, Eglen RM, Chan SL, Morgan NG, Crosby J (1999). Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues. Eur J Pharmacol, 378(2), 213-221. Abstract.  Author URL.
Morgan NG (1999). Imidazoline receptors: new targets for antihyperglycaemic drugs. Expert Opin Investig Drugs, 8(5), 575-584. Abstract.  Author URL.
Mourtada M, Chan SL, Smith SA, Morgan NG (1999). Multiple effector pathways regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets. Br J Pharmacol, 127(5), 1279-1287. Abstract.  Author URL.

1998

Eglen RM, Hudson AL, Kendall DA, Nutt DJ, Morgan NG, Wilson VG, Dillon MP (1998). 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. Trends Pharmacol Sci, 19(9), 381-390. Abstract.  Author URL.
El-Mansoury AM, Morgan NG (1998). Activation of protein kinase C modulates alpha2-adrenergic signalling in rat pancreatic islets. Cell Signal, 10(9), 637-643. Abstract.  Author URL.
Chan SL, Pallett AL, Clews J, Ramsden CA, Chapman JC, Kane C, Dunne MJ, Morgan NG (1998). Characterisation of new efaroxan derivatives for use in purification of imidazoline-binding sites. Eur J Pharmacol, 355(1), 67-76. Abstract.  Author URL.
Mourtada M, Smith SA, Morgan NG (1998). Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans. Eur J Pharmacol, 350(2-3), 251-258. Abstract.  Author URL.
Loweth AC, Williams GT, James RF, Scarpello JH, Morgan NG (1998). Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes, 47(5), 727-732. Abstract.  Author URL.
Loweth AC, Morgan NG (1998). Methods for the study of NO-induced apoptosis in cultured cells. Methods Mol Biol, 100, 311-320. Author URL.
Chan SL, Morgan NG (1998). Sigma receptor ligands and imidazoline secretagogues mediate their insulin secretory effects by activating distinct receptor systems in isolated islets. Eur J Pharmacol, 350(2-3), 267-272. Abstract.  Author URL.

1997

Chan SL, Pallett AL, Morgan NG (1997). Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch Pharmacol, 356(6), 763-768. Abstract.  Author URL.
Chan SL, Perrett CW, Morgan NG (1997). Differential expression of alpha 2-adrenoceptor subtypes in purified rat pancreatic islet A- and B-cells. Cell Signal, 9(1), 71-78. Abstract.  Author URL.
Loweth AC, Williams GT, Scarpello JH, Morgan NG (1997). Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15. FEBS Lett, 400(3), 285-288. Abstract.  Author URL.
Chan SL, Pallett AL, Clews J, Ramsden CA, Morgan NG (1997). Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with sigma receptors. Eur J Pharmacol, 323(2-3), 241-244. Abstract.  Author URL.
Mourtada M, Smith SA, Morgan NG (1997). Insulin secretagogues with an imidazoline structure inhibit arginine-induced secretion from isolated glucagon secretion from isolated rat islets of Langerhans. Biochem Biophys Res Commun, 236(1), 162-166. Abstract.  Author URL.
Mourtada M, Brown CA, Smith SA, Piercy V, Chan SL, Morgan NG (1997). Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion. Br J Pharmacol, 121(4), 799-805. Abstract.  Author URL.
Di Matteo MA, Loweth AC, Thomas S, Mabley JG, Morgan NG, Thorpe JR, Green IC (1997). Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms. Apoptosis, 2(2), 164-177. Abstract.  Author URL.
Chan SL, Atlas D, James RF, Morgan NG (1997). The effect of the putative endogenous imidazoline receptor ligand, clonidine-displacing substance, on insulin secretion from rat and human islets of Langerhans. Br J Pharmacol, 120(5), 926-932. Abstract.  Author URL.

1996

Loweth AC, Scarpello JH, Morgan NG (1996). A specific inhibitor of cytosolic phospholipase A2 activity, AACOCF3, inhibits glucose-induced insulin secretion from isolated rat islets. Biochem Biophys Res Commun, 218(2), 423-427. Abstract.  Author URL.
Lacey RJ, Chan SL, Cable HC, James RF, Perrett CW, Scarpello JH, Morgan NG (1996). Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans. J Endocrinol, 148(3), 531-543. Abstract.  Author URL.
Loweth AC, Williams GT, Scarpello JH, Morgan NG (1996). Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic beta-cells. Exp Cell Res, 229(1), 69-76. Abstract.  Author URL.
Morgan NG, Pallett AL, Mourtada M, Chan SLF, Clews J, Ramsden CA (1996). Synthesis and characterisation of KU14R a novel antagonist of the pancreatic islet imidazoline binding site. DIABETOLOGIA, 39, 456-456. Author URL.

1995

Cable HC, el-Mansoury A, Morgan NG (1995). Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells. Biochem J, 307 ( Pt 1), 169-174. Abstract.  Author URL.
Morgan NG, Chan SL, Brown CA, Tsoli E (1995). Characterization of the imidazoline binding site involved in regulation of insulin secretion. Ann N Y Acad Sci, 763, 361-373. Author URL.
LOWETH AC, SCARPELLO JHB, MORGAN NG (1995). PHOSPHOLIPASE A(2) EXPRESSION IN HUMAN AND RODENT INSULIN-SECRETING CELLS (VOL 112, PG 177, 1995). MOLECULAR AND CELLULAR ENDOCRINOLOGY, 114(1-2), 227-228. Author URL.
Chan SL, Brown CA, Scarpello KE, Morgan NG (1995). Pancreatic beta-cells express an imidazoline binding site that is distinct from I1 and I2 sites. Ann N Y Acad Sci, 763, 153-156. Author URL.
Loweth AC, Scarpello JH, Morgan NG (1995). Phospholipase A2 expression in human and rodent insulin-secreting cells. Mol Cell Endocrinol, 112(2), 177-183. Abstract.  Author URL.
Tsoli E, Chan SL, Morgan NG (1995). The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans. Eur J Pharmacol, 284(1-2), 199-203. Abstract.  Author URL.

1994

Loweth AC, Scarpello JH, Morgan NG (1994). A comparison of cytosolic phospholipase A2 expression in human islets of Langerhans and rodent insulin-secreting cells. Biochem Soc Trans, 22(4). Author URL.
Chan SL, Brown CA, Scarpello KE, Morgan NG (1994). The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites. Br J Pharmacol, 112(4), 1065-1070. Abstract.  Author URL.
Morgan NG, Cable HC, Newcombe NR, Williams GT (1994). Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis. Biosci Rep, 14(5), 243-250. Abstract.  Author URL.

1993

Brown CA, Chan SL, Stillings MR, Smith SA, Morgan NG (1993). Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080. Br J Pharmacol, 110(3), 1017-1022. Abstract.  Author URL.
Lacey RJ, Cable HC, James RF, London NJ, Scarpello JH, Morgan NG (1993). Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans. J Endocrinol, 138(3), 555-563. Abstract.  Author URL.
Brown CA, Morgan NG (1993). Control of insulin secretion by imidazolines in rat pancreatic islets. Biochem Soc Trans, 21(2). Author URL.
Brown CA, Loweth AC, Smith SA, Morgan NG (1993). Stimulation of insulin secretion by imidazoline compounds is not due to interaction with non-adrenoceptor idazoxan binding sites. Br J Pharmacol, 108(2), 312-317. Abstract.  Author URL.
Chan SL, Brown CA, Morgan NG (1993). Stimulation of insulin secretion by the imidazoline alpha 2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site. Eur J Pharmacol, 230(3), 375-378. Abstract.  Author URL.

1992

Lacey RJ, Scarpello JH, Morgan NG (1992). Evidence that the presence of arginine can lead to overestimation of glucagon levels measured by radioimmunoassay. Clin Chim Acta, 210(3), 211-219. Author URL.
Berrow NS, Milligan G, Morgan NG (1992). Immunological characterization of the guanine-nucleotide binding proteins Gi and Go in rat islets of Langerhans. J Mol Endocrinol, 8(2), 103-108. Abstract.  Author URL.
Berrow NS, Hurst RD, Chan SL, Morgan NG (1992). Immunoprecipitation of a pertussis toxin substrate of the G(o) family from rat islets of Langerhans. Biosci Rep, 12(2), 95-100. Abstract.  Author URL.

1991

Chan SL, Stillings MR, Morgan NG (1991). Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128. Biochem Biophys Res Commun, 176(3), 1545-1551. Abstract.  Author URL.
Lacey RJ, Berrow NS, Scarpello JH, Morgan NG (1991). Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat. Br J Pharmacol, 103(3), 1824-1828. Abstract.  Author URL.
Chan SL, Dunne MJ, Stillings MR, Morgan NG (1991). The alpha 2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells. Eur J Pharmacol, 204(1), 41-48. Abstract.  Author URL.

1990

Lacey RJ, Berrow NS, London NJ, Lake SP, James RF, Scarpello JH, Morgan NG (1990). Differential effects of beta-adrenergic agonists on insulin secretion from pancreatic islets isolated from rat and man. J Mol Endocrinol, 5(1), 49-54. Abstract.  Author URL.
Hurst RD, Morgan NG (1990). Evidence for differential effects of noradrenaline and somatostatin on intracellular messenger systems in rat islets of Langerhans. J Mol Endocrinol, 4(3), 231-237. Abstract.  Author URL.
Berrow NS, Morgan NG (1990). Evidence for the presence of low molecular mass GTP-binding proteins in rat islets of Langerhans. Biochem Soc Trans, 18(3), 485-486. Author URL.
Chan SL, Morgan NG (1990). Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels. Eur J Pharmacol, 176(1), 97-101. Abstract.  Author URL.

1989

Morgan NG, Hurst RD, Berrow NS, Montague W (1989). Calcium handling by stimulated islets of Langerhans. Biochem Soc Trans, 17(1), 64-66. Author URL.
Hurst RD, Chan SL, Morgan NG (1989). Effects of benextramine on the adrenergic inhibition of insulin secretion in isolated rat pancreatic islets. J Mol Endocrinol, 2(2), 99-105. Abstract.  Author URL.
Chan SL, Morgan NG (1989). Effects of phenoxybenzamine on insulin secretion from isolated rat islets of Langerhans. Biosci Rep, 9(2), 223-230. Abstract.  Author URL.
Hurst RD, Morgan NG (1989). Intracellular events responsible for the inhibition of insulin secretion by somatostatin. Biochem Soc Trans, 17(6), 1085-1086. Author URL.

1988

Morgan NG, Hurst RD (1988). Dissociation between intracellular calcium mobilization and insulin secretion in isolated rat islets of Langerhans. FEBS Lett, 227(2), 153-156. Abstract.  Author URL.

1987

Morgan NG, Rumford GM, Montague W (1987). Mechanisms involved in intracellular calcium mobilization in isolated rat islets of Langerhans. Biochem J, 244(3), 669-674. Abstract.  Author URL.
MORGAN NG (1987). REGULATION OF INSULIN-SECRETION BY ALPHA-2-ADRENERGIC AGONISTS. TRENDS IN PHARMACOLOGICAL SCIENCES, 8(10), 369-370. Author URL.

1985

Montague W, Morgan NG, Rumford GM, Prince CA (1985). Effect of glucose on polyphosphoinositide metabolism in isolated rat islets of Langerhans. Biochem J, 227(2), 483-489. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Effects of noradrenaline on 45Ca2+ efflux from isolated rat islets of Langerhans. Biosci Rep, 5(12), 1053-1060. Abstract.  Author URL.
Morgan NG, Short CD, Rumford GM, Montague W (1985). Effects of the calcium-channel agonist CGP 28392 on insulin secretion from isolated rat islets of Langerhans. Biochem J, 231(3), 629-634. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Studies on the mechanism by which melittin stimulates insulin secretion from isolated rat islets of Langerhans. Biochim Biophys Acta, 845(3), 526-532. Abstract.  Author URL.
Morgan NG, Montague W (1985). Studies on the mechanism of inhibition of glucose-stimulated insulin secretion by noradrenaline in rat islets of Langerhans. Biochem J, 226(2), 571-576. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Studies on the role of inositol trisphosphate in the regulation of insulin secretion from isolated rat islets of Langerhans. Biochem J, 228(3), 713-718. Abstract.  Author URL.

1984

Morgan NG, Charest R, Blackmore PF, Exton JH (1984). Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism. Proc Natl Acad Sci U S A, 81(13), 4208-4212. Abstract.  Author URL.
Morgan NG, Montague W (1984). Stimulation of insulin secretion from isolated rat islets of Langerhans by melittin. Biosci Rep, 4(8), 665-671. Abstract.  Author URL.

1983

Morgan NG, Blackmore PF, Exton JH (1983). Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats. J Biol Chem, 258(8), 5103-5109. Abstract.  Author URL.
Morgan NG, Exton JH, Blackmore PF (1983). Angiotensin II inhibits hepatic cAMP accumulation induced by glucagon and epinephrine and their metabolic effects. FEBS Lett, 153(1), 77-80. Abstract.  Author URL.
Morgan NG, Waynick LE, Exton JH (1983). Characterisation of the alpha 1-adrenergic control of hepatic cAMP in male rats. Eur J Pharmacol, 96(1-2), 1-10. Abstract.  Author URL.
Morgan NG, Blackmore PF, Exton JH (1983). Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP. J Biol Chem, 258(8), 5110-5116. Abstract.  Author URL.
Morgan NG, Shipp CC, Exton JH (1983). Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin. FEBS Lett, 163(2), 277-281. Abstract.  Author URL.

1982

Morgan NG, Shuman EA, Exton JH, Blackmore PF (1982). Stimulation of hepatic glycogenolysis by alpha 1- and beta 2-adrenergic agonists. Evidence against short term agonist-induced desensitization of the responses. J Biol Chem, 257(23), 13907-13910. Abstract.  Author URL.
Morgan NG, Montague W (1982). Studies on the interaction of staphylococcal delta-haemolysin with isolated islets of Langerhans. Biochem J, 204(1), 111-125. Abstract.  Author URL.

1981

Morgan NG, Fitzhugh AJ, Montague W (1981). The effect of staphylococcal delta-haemolysin on the secretory activity of the pancreatic beta-cell. Biosci Rep, 1(2), 135-140. Abstract.  Author URL.

1979

Ducommun Y, Morgan NG, Montague W (1979). Subcellular distribution of protein kinase activities in mammalian islets of Langerhans [proceedings]. Biochem Soc Trans, 7(5), 913-915. Author URL.

Committee/panel activities

Diabetes UK; Chair of Science and Research Advisory Group.

Diabetes UK; Research Fellowships panel member

European Foundation for Study of Diabetes; research grant panels.


Editorial responsibilities

Islets (Landes Bioscience)

BMC Pharmacology


Invited lectures

European Association for Study of Diabetes (Munich, 2016)

Pancreatic Society (Norwich, 2015)

PEVNET symposium (Sweden 2016)

JDRF nPOD Conference (Florida, 2016)

ISPAD Conference (Brisbane, 2015)


Media Coverage

Interviews on:
BBC News; Sky News; BBC Radio 5 live; BBC Local Radio (Devon & Cornwall); BBC Radio Wales

  • Plenary lecturer; Academic tutor, Special Study Unit Convenor.
  • Director of Postgraduate Research; Chair of Research Degrees Committee.

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