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Dr Janice Atkins   (nee Hunkin )

Dr Janice Atkins (nee Hunkin )

NIHR Advanced Fellow

 6809

 01392 726809

 College House 1.09

 

College House, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK

Overview

Janice is a post-doctoral research fellow in the Epidemiology and Public Health group at the University of Exeter Medical School. Janice's research  focuses on the analysis of environmental and genetic risk factors of ageing and age-related diseases. Janice has a particular research interest in the common genetic condition hereditary haemochromatosis, which can cause iron overload. Janice currently holds an NIHR Advanced Fellowship on "Enabling timely diagnosis of hereditary haemochromatosis".

Prior to joining the University of Exeter, Janice undertook a PhD at University College London, funded by the NIHR School for Primary Care Research. Janice’s PhD explored the effects of body composition and dietary patterns on the risk of cardiovascular disease and mortality in older age, using longitudinal data from the British Regional Heart Study.

Qualifications

  • 2020                   Associate Fellow of the Higher Education Academy (University of Exeter)
  • 2015                   PhD Epidemiology (University College London)
  • 2011                   MSc Epidemiology (London School of Hygiene and Tropical Medicine)
  • 2004                   BSc (Hons) Human Biology (Loughborough University)

Career

  • 2015–current    Research Fellow (University of Exeter Medical School)
  • 2008–2011        Scientist(Public Health England, formerly Health Protection Agency)
  • 2005–2007        Research Assistant (King’s College London)

 

Links

Research group links

Research

Research interests

Haemochromatosis

Janice currently holds an NIHR Advanced Fellowship, investigating how to improve the diagnosis of hereditary haemochromatosis. Previously Janice worked on an MRC funded grant on “Genetic variation, iron and later life health outcomes” from 2019 to 2021.

Haemochromatosis is a disorder of iron overload, causing people to absorb too much iron from their diet. This iron can build up to toxic levels in body organs, causing disease. Haemochromatosis is the most common genetic condition in the UK, but people are often diagnosed too late. Recent research from the Epidemiology and Public Health Group found that people who carry two copies of the mutation (called p.C282Y in gene HFE) had substantial excess morbidity; 1 in 5 of these males and 1 in 10 females aged 40 to 70 developed additional disease, compared to those without mutations (published in the BMJ). My research has also found that male p.C282Y homozygotes have a ten-fold increase in the risk of liver cancer (Atkins et al, JAMA, 2020) and a doubling in the risk of dementia (Atkins et al, JAD, 2021) compared to those without mutations.

The symptoms of haemochromatosis, chronic fatigue and joint pain, are often mistaken for "normal" signs of ageing, and thus diagnosis is often missed or delayed. Haemochromatosis is easily treated by the removal of blood, and blood tests for iron and genetic testing are simple and cost-effective. Therefore the research suggests that routine screening or improved case finding may be needed to identify people at risk of haemochromatosis.

 

Longevity and Healthy Ageing

Janice’s research interests also include the epidemiology of ageing and age-related diseases. From 2015 to 2019 Janice worked on an MRC funded grant examining "Genetic and environmental influences on ageing well in the UK Biobank.” Her role was to analyse conventional and novel risk factors and genetic variants associated with ageing well, using data from the UK Biobank study – a large prospective cohort of 500,000 volunteers aged 40-69 years, with genotype data in combination with extensive phenotyping and linkage to medical records.

 

Grants/Funding

  • Enabling timely diagnosis of hereditary haemochromatosis. Principal investigator.NIHR Advanced Fellowship. £314,985. 2021-2025.
  • Genetic variation, iron and later life health outcomes. Co-applicant. Medical Research Council. £291,820. 2019-2021. 
  • Hereditary haemochromaotosis - Cost of Illness Study. Principal investigator. Heamochromatosis UK, Fernau Medical Research Award. £3,930. 2020.
  • Identifying haemochromatosis patients from DXA images of bones and joints using deep learning methods. Co-applicant. Wellcome Trust Institutional Strategic Support Fund (ISSF) Seed corn project. £3,410. 2019.
  • Body composition, dietary patterns, cardiovascular disease and mortality in older age. Principal investigator. NIHR School for Primary Care Research, PhD studentship. £85,260. 2011-2015. 

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Kuo C-L, Pilling LC, Atkins JL, Kuchel GA, Melzer D (In Press). <i>ApoE</i> e2 and aging-related outcomes in 379,000 UK Biobank participants.  Abstract.  Full text.
Atkins J (In Press). Hereditary hemochromatosis variant associations with incident non-liver malignancies: 11-year follow-up in UK Biobank. Cancer Epidemiology, Biomarkers and Prevention Full text.
Atkins J, Masoli J, Correa-Delgado J, Pilling L, Kuo C-L, Melzer D, Kuchel G (In Press). PREEXISTING COMORBIDITIES PREDICTING COVID-19 AND MORTALITY IN THE UK BIOBANK COMMUNITY COHORT. Journal of Gerontology Series A: Biological Sciences and Medical Sciences Full text.
Kuo C-L, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Melzer D (2022). APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence from a Large UK Cohort. J Gerontol a Biol Sci Med Sci, 77(4), 879-880. Author URL.
Pilling LC, Atkins JL, Melzer D (2022). Genetic modifiers of penetrance to liver endpoints in HFE hemochromatosis: Associations in a large community cohort. Hepatology Abstract.  Author URL.
Atkins JL, Jylhävä J, Pedersen NL, Magnusson PK, Lu Y, Wang Y, Hägg S, Melzer D, Williams DM, Pilling LC, et al (2021). A genome-wide association study of the frailty index highlights brain pathways in ageing. Aging Cell, 20(9). Abstract.  Author URL.
Pilling LC, Turkmen D, Fullalove H, Atkins JL, Delgado J, Kuo C-L, Kuchel GA, Ferrucci L, Bowden J, Masoli JAH, et al (2021). Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study. BMJ OPEN, 11(12). Author URL.  Full text.
Kuo C-L, Pilling L, Atkins J, Masoli J, Delgado J, Kuchel G, Melzer D, Levine M (2021). Antipsychotic Prescribing in VA-Contracted Community Nursing Homes and Incident Use Among Veterans. Innovation in Aging, 5(Suppl 1), 333-333.
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Tignanelli C, Kuchel GA, Melzer D, Beckman KB, Levine ME, et al (2021). Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants. The Journals of Gerontology: Series A, 76(8), e133-e141. Abstract.
Kuo C-L, Pilling LC, Liu Z, Atkins JL, Levine ME (2021). Genetic associations for two biological age measures point to distinct aging phenotypes. Aging Cell, 20(6). Abstract.  Author URL.
Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo C-L, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, et al (2021). Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nature Communications, 12(1). Abstract.
Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo C-L, Kuchel GA, Steffens DC, Melzer D (2021). Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort. Journal of Alzheimer's Disease, 79(3), 1203-1211. Abstract.  Full text.
Lochlainn MN, Cox NJ, Wilson T, Hayhoe RPG, Ramsay SE, Granic A, Isanejad M, Roberts HC, Wilson D, Welch C, et al (2021). Nutrition and frailty: Opportunities for prevention and treatment. Nutrients, 13(7). Abstract.
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (2020). APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort. J Gerontol a Biol Sci Med Sci, 75(11), 2231-2232. Author URL.
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (2020). ApoE e4e4 Genotype and Mortality with COVID-19 in UK Biobank. The Journals of Gerontology: Series A, 75(9), 1801-1803. Full text.
Atkins JL, Pilling LC, Masoli JAH, Kuo C-L, Shearman JD, Adams PC, Melzer D (2020). Association of Hemochromatosis <i>HFE</i> p.C282Y Homozygosity with Hepatic Malignancy. JAMA, 324(20), 2048-2048. Full text.
Pilling LC, Jones LC, Masoli JAH, Delgado J, Atkins JL, Bowden J, Fortinsky RH, Kuchel GA, Melzer D (2020). Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older. <scp>UK</scp>. Biobank Participants. Journal of the American Geriatrics Society, 69(2), 365-372. Full text.
Atkins JL, Wannamathee SG (2020). Sarcopenic obesity in ageing: cardiovascular outcomes and mortality. British Journal of Nutrition, 124(10), 1102-1113. Abstract.
Tian Q, Pilling LC, Atkins JL, Melzer D, Ferrucci L (2020). The relationship of parental longevity with the aging brain—results from UK Biobank. GeroScience, 42(5), 1377-1385. Abstract.  Full text.
Parsons TJ, Papachristou E, Atkins JL, Papacosta O, Ash S, Lennon LT, Whincup PH, Ramsay SE, Wannamethee SG (2019). Healthier diet quality and dietary patterns are associated with lower risk of mobility limitation in older men. Eur J Nutr, 58(6), 2335-2343. Abstract.  Author URL.
Tamosauskaite J, Atkins J, Pilling L, Kuo C-L, Kuchel G, Ferrucci L, Melzer D (2019). Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants. Journals of Gerontology - Series a Biological Sciences and Medical Sciences Full text.
Atkins JL, Delgado J, Melzer D (2019). Life’s Simple 7 likely to be associated with dementia risk reduction in both midlife and older age groups. BMJ, l5491-l5491.
Parsons TJ, Papachristou E, Atkins JL, Papacosta O, Ash S, Lennon LT, Whincup PH, Ramsay SE, Wannamethee SG (2019). Physical frailty in older men: prospective associations with diet quality and patterns. Age Ageing, 48(3), 355-360. Abstract.  Author URL.
Atkins JL, Delgado J, Pilling L, Bowman K, Masoli J, Kuchel G, Ferrucci L, Melzer D (2018). Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence from 421,000 Participants in Two Cohorts. Journals of Gerontology: Medical Sciences Full text.
Pilling LC, Atkins JL, Kuchel GA, Ferrucci L, Melzer D (2018). Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years. PLoS ONE, 13(9). Abstract.  Full text.
Bowman K, Atkins JL, Delgado J, Kos K, Kuchel GA, Ble A, Ferrucci L, Melzer D (2017). Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants. Am J Clin Nutr, 106(1), 130-135. Abstract.  Author URL.  Full text.
Hawkesworth S, Silverwood RJ, Armstrong B, Pliakas T, Nanchahal K, Sartini C, Amuzu A, Wannamethee G, Atkins J, Ramsay SE, et al (2017). Investigating the importance of the local food environment for fruit and vegetable intake in older men and women in 20 UK towns: a cross-sectional analysis of two national cohorts using novel methods. INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY, 14 Author URL.  Full text.
Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2016). Dietary patterns and the risk of CVD and all-cause mortality in older British men. Br J Nutr, 116(7), 1246-1255. Abstract.  Author URL.  Full text.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine JM, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. Journal of the American College of Cardiology, 68(8), 874-875. Full text.
Atkins JL, Ramsay SE, Whincup PH, Morris RW, Lennon LT, Wannamethee SG (2015). Diet quality in older age: the influence of childhood and adult socio-economic circumstances. British Journal of Nutrition, 113(9), 1441-1452. Abstract.
Wannamethee SG, Atkins JL (2015). Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity. Proceedings of the Nutrition Society, 74(4), 405-412. Abstract.
Atkins JL, Wannamethee SG (2015). The effect of sarcopenic obesity on cardiovascular disease and all-cause mortality in older people. Reviews in Clinical Gerontology, 25(2), 86-97. Abstract.
Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2014). High Diet Quality is Associated with a Lower Risk of Cardiovascular Disease and All-Cause Mortality in Older Men. The Journal of Nutrition, 144(5), 673-680.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2014). Response to Safer et al. Journal of the American Geriatrics Society, 62(6), 1208-1209.
Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2014). Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: a Population‐Based Cohort Study of Older Men. Journal of the American Geriatrics Society, 62(2), 253-260.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). Low muscle mass in older men: the role of lifestyle, diet and cardiovascular risk factors. The journal of nutrition, health & aging, 18(1), 26-33.
Woodhall SC, Atkins JL, Soldan K, Hughes G, Bone A, Gill ON (2012). Repeat genital<i>Chlamydia trachomatis</i>testing rates in young adults in England, 2010. Sexually Transmitted Infections, 89(1), 51-56.
Nicolaou N, Shane S, Cherkas L, Hunkin J, Spector TD (2008). Is the Tendency to Engage in Entrepreneurship Genetic?. Management Science, 54(1), 167-179.
Kimura M, Cherkas LF, Kato BS, Demissie S, Hjelmborg JB, Brimacombe M, Cupples A, Hunkin JL, Gardner JP, Lu X, et al (2008). Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm. PLoS Genetics, 4(2), e37-e37. Full text.
Cherkas LF (2008). The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length. Archives of Internal Medicine, 168(2), 154-154.
Stubbe JH, Boomsma DI, Vink JM, Cornes BK, Martin NG, Skytthe A, Kyvik KO, Rose RJ, Kujala UM, Kaprio J, et al (2006). Genetic Influences on Exercise Participation in 37.051 Twin Pairs from Seven Countries. PLoS ONE, 1(1), e22-e22. Full text.
Paul SN, Kato BS, Hunkin JL, Vivekanandan S, Spector TD, Fields KB (2006). The Big Finger: the second to fourth digit ratio is a predictor of sporting ability in women. Commentary. British Journal of Sports Medicine, 40(12), 981-983.
Cherkas LF, Aviv A, Valdes AM, Hunkin JL, Gardner JP, Surdulescu GL, Kimura M, Spector TD (2006). The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell, 5(5), 361-365.

Chapters

Atkins JL (2018). Chapter 7. Effects of sarcopenic obesity on cardiovascular disease and all-cause mortality. In Walrand S (Ed) Nutrition and Skeletal Muscle, Academic Press.
Atkins JL, Wannamethee SG (2015). Chapter 13. Diet quality and cardiovascular disease prevention. In Bendich A, Deckelbaum RJ (Eds.) Preventive Nutrition: the Comprehensive Guide for Health Professionals, New York: Humana Press.

Conferences

Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo C-L, Kuchel GA, Steffens DC, Melzer D (2022). Hereditary haemochromatosis mutations, brain iron imaging and dementia risk in the UK Biobank cohort.  Author URL.
Masoli J, Atkins J, Delgado J, Pilling L, Melzer D (2021). BEING NON-FRAIL AND FREE FROM CARDIOVASCULAR DISEASE REDUCES COVID-19 RISK IN 269,164 OLDER UK BIOBANK PARTICIPANTS.  Author URL.
Kuo C-L, Pilling L, Atkins J, Masoli J, Delgado J, Kuchel G, Melzer D, Levine M (2021). Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants.
Masoli J, Kuo CL, Atkins J, Pilling L, Delgado J, Kuchel G, Melzer D (2021). DEMENTIA, ApoE AND COVID-19 SEVERITY.  Author URL.
Atkins J, Masoli J, Delgado J, Pilling L, Kuo C-L, Kuchel G, Melzer D (2021). Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort.
Atkins J, Pilling LC, Williams D, Jylhävä J, Melzer D (2019). CAUSES OF FRAILTY: GENETIC ANALYSIS IN 164,000 UK BIOBANK PARTICIPANTS.
Jylhava J, Pilling L, Williams D, Lu Y, Pedersen NL, Melzer D, Atkins J (2019). Genome-wide association study of a frailty Index in UK Biobank and TwinGene.  Author URL.
Atkins J, Pilling L, Melzer D (2019). OP37: HEREDITARY HAEMOCHROMATOSIS: ASSOCIATIONS WITH MORBIDITY AND IRON SUPPLEMENT USE IN 451,243 UK BIOBANK PARTICIPANTS. Society for Social Medicine & Population Health and International Epidemiology Association European Congress Joint Annual Scientific Meeting. 4th - 6th Sep 2019. Full text.
Atkins JL, Delgado J, Pilling LC, Bowman K, Masoli JAH, Kuchel GA, Ferrucci L, Melzer D (2018). #IDEAL CARDIOVASCULAR RISK PROFILES AND AGEING: EVIDENCE FROM 421,000 OLDER PERSONS IN TWO COHORTS.  Author URL.
Melzer D, Pilling L, Atkins J, Tamosauskaite J (2018). IRON OVERLOAD AS a TREATABLE CAUSE OF FRAILTY: GENETIC EVIDENCE IN 200,000 SUBJECTS.
Atkins J, Pilling LC, Melzer D, Bowman K (2017). CAN GENETICS CLARIFY THE RISK PARADOXES OF LATER LIFE?.
Parsons TJ, Papachristou E, Ramsay SE, Atkins JL, Papacosta O, Lennon LT, Ash S, Whincup PH, Wannamethee SG (2017). DIET QUALITY, SARCOPENIA AND FRAILTY IN OLDER MEN: CROSS SECTIONAL ANALYSIS FROM THE BRITISH REGIONAL HEART STUDY.  Author URL.
Pilling LC, Atkins J, Melzer D (2017). GENETIC VARIANTS FOR AGING WELL SUGGEST POTENTIAL FOR INTERVENTION.
Atkins J, Pilling L, Ble A, Dutta A, Harries L, Murray A, Brayne C, Robine J, Kuchel G, Ferrucci L, et al (2016). OP82 Long-lived parents and cardiovascular outcomes: 8 year follow-up in 189,000 UK Biobank participants.
Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta P, Wannamethee SG (2015). Abstract P049: Principal Component Analysis of Dietary Patterns and the Risk of Cardiovascular Disease and Mortality in Older British Men.
Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2013). Dietary patterns and the risk of cardiovascular disease and mortality: a population-based cohort study of older British men.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). Dietary patterns in older British men: the influence of early life social circumstances and area of residence.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). OP86 Dietary Patterns in Older Men: Influence of Early Life Social Circumstances and Area of Residence.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). T1: P.039 Sarcopenic obesity and the risk of cardiovascular disease and mortality: a population-based cohort study of older men.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). T2: P.057 Dietary patterns in the elderly: Influence of early life social circumstances and area of residence.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2012). PS38 Sarcopenic Obesity and Risk of All-Cause and Cardiovascular Mortality in Older Men.
Cherkas L, Harris J, Hunkin J, Kato B, Zhang G, Valdes A, Aviv A, Spector TD, Atkins JL (2007). Twins, telomeres and aging.

Publications by year


In Press

Kuo C-L, Pilling LC, Atkins JL, Kuchel GA, Melzer D (In Press). <i>ApoE</i> e2 and aging-related outcomes in 379,000 UK Biobank participants.  Abstract.  Full text.
Atkins JL, Pilling LC, Torti SV, Torti FM, Kuchel GA, Melzer D (In Press). Hereditary haemochromatosis beyond liver cancer: increased risk of prostate cancer during an 11-year follow-up.  Abstract.
Atkins J (In Press). Hereditary hemochromatosis variant associations with incident non-liver malignancies: 11-year follow-up in UK Biobank. Cancer Epidemiology, Biomarkers and Prevention Full text.
Atkins J, Masoli J, Correa-Delgado J, Pilling L, Kuo C-L, Melzer D, Kuchel G (In Press). PREEXISTING COMORBIDITIES PREDICTING COVID-19 AND MORTALITY IN THE UK BIOBANK COMMUNITY COHORT. Journal of Gerontology Series A: Biological Sciences and Medical Sciences Full text.
Pilling LC, Atkins JL, Melzer D (In Press). Penetrance of <i>HFE</i> haemochromatosis variants to clinical disease: polygenic risk score associations in UK Biobank.  Abstract.

2022

Kuo C-L, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Melzer D (2022). APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence from a Large UK Cohort. J Gerontol a Biol Sci Med Sci, 77(4), 879-880. Author URL.
Pilling LC, Atkins JL, Melzer D (2022). Genetic modifiers of penetrance to liver endpoints in HFE hemochromatosis: Associations in a large community cohort. Hepatology Abstract.  Author URL.
Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo C-L, Kuchel GA, Steffens DC, Melzer D (2022). Hereditary haemochromatosis mutations, brain iron imaging and dementia risk in the UK Biobank cohort.  Author URL.

2021

Atkins JL, Jylhävä J, Pedersen NL, Magnusson PK, Lu Y, Wang Y, Hägg S, Melzer D, Williams DM, Pilling LC, et al (2021). A genome-wide association study of the frailty index highlights brain pathways in ageing. Aging Cell, 20(9). Abstract.  Author URL.
Pilling LC, Turkmen D, Fullalove H, Atkins JL, Delgado J, Kuo C-L, Kuchel GA, Ferrucci L, Bowden J, Masoli JAH, et al (2021). Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study. BMJ OPEN, 11(12). Author URL.  Full text.
Kuo C-L, Pilling L, Atkins J, Masoli J, Delgado J, Kuchel G, Melzer D, Levine M (2021). Antipsychotic Prescribing in VA-Contracted Community Nursing Homes and Incident Use Among Veterans. Innovation in Aging, 5(Suppl 1), 333-333.
Masoli J, Atkins J, Delgado J, Pilling L, Melzer D (2021). BEING NON-FRAIL AND FREE FROM CARDIOVASCULAR DISEASE REDUCES COVID-19 RISK IN 269,164 OLDER UK BIOBANK PARTICIPANTS.  Author URL.
Kuo C-L, Pilling L, Atkins J, Masoli J, Delgado J, Kuchel G, Melzer D, Levine M (2021). Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants.
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Tignanelli C, Kuchel GA, Melzer D, Beckman KB, Levine ME, et al (2021). Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants. The Journals of Gerontology: Series A, 76(8), e133-e141. Abstract.
Masoli J, Kuo CL, Atkins J, Pilling L, Delgado J, Kuchel G, Melzer D (2021). DEMENTIA, ApoE AND COVID-19 SEVERITY.  Author URL.
Kuo C-L, Pilling LC, Liu Z, Atkins JL, Levine ME (2021). Genetic associations for two biological age measures point to distinct aging phenotypes. Aging Cell, 20(6). Abstract.  Author URL.
Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo C-L, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, et al (2021). Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nature Communications, 12(1). Abstract.
Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo C-L, Kuchel GA, Steffens DC, Melzer D (2021). Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort. Journal of Alzheimer's Disease, 79(3), 1203-1211. Abstract.  Full text.
Lochlainn MN, Cox NJ, Wilson T, Hayhoe RPG, Ramsay SE, Granic A, Isanejad M, Roberts HC, Wilson D, Welch C, et al (2021). Nutrition and frailty: Opportunities for prevention and treatment. Nutrients, 13(7). Abstract.
Atkins J, Masoli J, Delgado J, Pilling L, Kuo C-L, Kuchel G, Melzer D (2021). Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort.

2020

Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (2020). APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort. J Gerontol a Biol Sci Med Sci, 75(11), 2231-2232. Author URL.
Kuo C-L, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (2020). ApoE e4e4 Genotype and Mortality with COVID-19 in UK Biobank. The Journals of Gerontology: Series A, 75(9), 1801-1803. Full text.
Atkins JL, Pilling LC, Masoli JAH, Kuo C-L, Shearman JD, Adams PC, Melzer D (2020). Association of Hemochromatosis <i>HFE</i> p.C282Y Homozygosity with Hepatic Malignancy. JAMA, 324(20), 2048-2048. Full text.
Pilling LC, Jones LC, Masoli JAH, Delgado J, Atkins JL, Bowden J, Fortinsky RH, Kuchel GA, Melzer D (2020). Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older. <scp>UK</scp>. Biobank Participants. Journal of the American Geriatrics Society, 69(2), 365-372. Full text.
Atkins JL, Wannamathee SG (2020). Sarcopenic obesity in ageing: cardiovascular outcomes and mortality. British Journal of Nutrition, 124(10), 1102-1113. Abstract.
Tian Q, Pilling LC, Atkins JL, Melzer D, Ferrucci L (2020). The relationship of parental longevity with the aging brain—results from UK Biobank. GeroScience, 42(5), 1377-1385. Abstract.  Full text.

2019

Atkins J, Pilling LC, Williams D, Jylhävä J, Melzer D (2019). CAUSES OF FRAILTY: GENETIC ANALYSIS IN 164,000 UK BIOBANK PARTICIPANTS.
Jylhava J, Pilling L, Williams D, Lu Y, Pedersen NL, Melzer D, Atkins J (2019). Genome-wide association study of a frailty Index in UK Biobank and TwinGene.  Author URL.
Parsons TJ, Papachristou E, Atkins JL, Papacosta O, Ash S, Lennon LT, Whincup PH, Ramsay SE, Wannamethee SG (2019). Healthier diet quality and dietary patterns are associated with lower risk of mobility limitation in older men. Eur J Nutr, 58(6), 2335-2343. Abstract.  Author URL.
Tamosauskaite J, Atkins J, Pilling L, Kuo C-L, Kuchel G, Ferrucci L, Melzer D (2019). Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants. Journals of Gerontology - Series a Biological Sciences and Medical Sciences Full text.
Atkins JL, Delgado J, Melzer D (2019). Life’s Simple 7 likely to be associated with dementia risk reduction in both midlife and older age groups. BMJ, l5491-l5491.
Atkins J, Pilling L, Melzer D (2019). OP37: HEREDITARY HAEMOCHROMATOSIS: ASSOCIATIONS WITH MORBIDITY AND IRON SUPPLEMENT USE IN 451,243 UK BIOBANK PARTICIPANTS. Society for Social Medicine & Population Health and International Epidemiology Association European Congress Joint Annual Scientific Meeting. 4th - 6th Sep 2019. Full text.
Parsons TJ, Papachristou E, Atkins JL, Papacosta O, Ash S, Lennon LT, Whincup PH, Ramsay SE, Wannamethee SG (2019). Physical frailty in older men: prospective associations with diet quality and patterns. Age Ageing, 48(3), 355-360. Abstract.  Author URL.

2018

Atkins JL, Delgado J, Pilling LC, Bowman K, Masoli JAH, Kuchel GA, Ferrucci L, Melzer D (2018). #IDEAL CARDIOVASCULAR RISK PROFILES AND AGEING: EVIDENCE FROM 421,000 OLDER PERSONS IN TWO COHORTS.  Author URL.
Atkins JL (2018). Chapter 7. Effects of sarcopenic obesity on cardiovascular disease and all-cause mortality. In Walrand S (Ed) Nutrition and Skeletal Muscle, Academic Press.
Melzer D, Pilling L, Atkins J, Tamosauskaite J (2018). IRON OVERLOAD AS a TREATABLE CAUSE OF FRAILTY: GENETIC EVIDENCE IN 200,000 SUBJECTS.
Atkins JL, Delgado J, Pilling L, Bowman K, Masoli J, Kuchel G, Ferrucci L, Melzer D (2018). Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence from 421,000 Participants in Two Cohorts. Journals of Gerontology: Medical Sciences Full text.
Pilling LC, Atkins JL, Kuchel GA, Ferrucci L, Melzer D (2018). Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years. PLoS ONE, 13(9). Abstract.  Full text.

2017

Atkins J, Pilling LC, Melzer D, Bowman K (2017). CAN GENETICS CLARIFY THE RISK PARADOXES OF LATER LIFE?.
Bowman K, Atkins JL, Delgado J, Kos K, Kuchel GA, Ble A, Ferrucci L, Melzer D (2017). Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants. Am J Clin Nutr, 106(1), 130-135. Abstract.  Author URL.  Full text.
Parsons TJ, Papachristou E, Ramsay SE, Atkins JL, Papacosta O, Lennon LT, Ash S, Whincup PH, Wannamethee SG (2017). DIET QUALITY, SARCOPENIA AND FRAILTY IN OLDER MEN: CROSS SECTIONAL ANALYSIS FROM THE BRITISH REGIONAL HEART STUDY.  Author URL.
Pilling LC, Atkins J, Melzer D (2017). GENETIC VARIANTS FOR AGING WELL SUGGEST POTENTIAL FOR INTERVENTION.
Hawkesworth S, Silverwood RJ, Armstrong B, Pliakas T, Nanchahal K, Sartini C, Amuzu A, Wannamethee G, Atkins J, Ramsay SE, et al (2017). Investigating the importance of the local food environment for fruit and vegetable intake in older men and women in 20 UK towns: a cross-sectional analysis of two national cohorts using novel methods. INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY, 14 Author URL.  Full text.

2016

Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2016). Dietary patterns and the risk of CVD and all-cause mortality in older British men. Br J Nutr, 116(7), 1246-1255. Abstract.  Author URL.  Full text.
Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine JM, Kuchel GA, Ferrucci L, et al (2016). Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up in 186,000 U.K. Biobank Participants. Journal of the American College of Cardiology, 68(8), 874-875. Full text.
Atkins J, Pilling L, Ble A, Dutta A, Harries L, Murray A, Brayne C, Robine J, Kuchel G, Ferrucci L, et al (2016). OP82 Long-lived parents and cardiovascular outcomes: 8 year follow-up in 189,000 UK Biobank participants.

2015

Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta P, Wannamethee SG (2015). Abstract P049: Principal Component Analysis of Dietary Patterns and the Risk of Cardiovascular Disease and Mortality in Older British Men.
Atkins JL, Wannamethee SG (2015). Chapter 13. Diet quality and cardiovascular disease prevention. In Bendich A, Deckelbaum RJ (Eds.) Preventive Nutrition: the Comprehensive Guide for Health Professionals, New York: Humana Press.
Atkins JL, Ramsay SE, Whincup PH, Morris RW, Lennon LT, Wannamethee SG (2015). Diet quality in older age: the influence of childhood and adult socio-economic circumstances. British Journal of Nutrition, 113(9), 1441-1452. Abstract.
Wannamethee SG, Atkins JL (2015). Muscle loss and obesity: the health implications of sarcopenia and sarcopenic obesity. Proceedings of the Nutrition Society, 74(4), 405-412. Abstract.
Atkins JL, Wannamethee SG (2015). The effect of sarcopenic obesity on cardiovascular disease and all-cause mortality in older people. Reviews in Clinical Gerontology, 25(2), 86-97. Abstract.

2014

Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2014). High Diet Quality is Associated with a Lower Risk of Cardiovascular Disease and All-Cause Mortality in Older Men. The Journal of Nutrition, 144(5), 673-680.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2014). Response to Safer et al. Journal of the American Geriatrics Society, 62(6), 1208-1209.
Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2014). Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: a Population‐Based Cohort Study of Older Men. Journal of the American Geriatrics Society, 62(2), 253-260.

2013

Atkins JL, Whincup PH, Morris RW, Lennon LT, Papacosta O, Wannamethee SG (2013). Dietary patterns and the risk of cardiovascular disease and mortality: a population-based cohort study of older British men.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). Dietary patterns in older British men: the influence of early life social circumstances and area of residence.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). Low muscle mass in older men: the role of lifestyle, diet and cardiovascular risk factors. The journal of nutrition, health & aging, 18(1), 26-33.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). OP86 Dietary Patterns in Older Men: Influence of Early Life Social Circumstances and Area of Residence.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). T1: P.039 Sarcopenic obesity and the risk of cardiovascular disease and mortality: a population-based cohort study of older men.
Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2013). T2: P.057 Dietary patterns in the elderly: Influence of early life social circumstances and area of residence.

2012

Atkins JL, Whincup PH, Morris RW, Wannamethee SG (2012). PS38 Sarcopenic Obesity and Risk of All-Cause and Cardiovascular Mortality in Older Men.
Woodhall SC, Atkins JL, Soldan K, Hughes G, Bone A, Gill ON (2012). Repeat genital<i>Chlamydia trachomatis</i>testing rates in young adults in England, 2010. Sexually Transmitted Infections, 89(1), 51-56.

2008

Nicolaou N, Shane S, Cherkas L, Hunkin J, Spector TD (2008). Is the Tendency to Engage in Entrepreneurship Genetic?. Management Science, 54(1), 167-179.
Kimura M, Cherkas LF, Kato BS, Demissie S, Hjelmborg JB, Brimacombe M, Cupples A, Hunkin JL, Gardner JP, Lu X, et al (2008). Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm. PLoS Genetics, 4(2), e37-e37. Full text.
Cherkas LF (2008). The Association Between Physical Activity in Leisure Time and Leukocyte Telomere Length. Archives of Internal Medicine, 168(2), 154-154.

2007

Cherkas L, Harris J, Hunkin J, Kato B, Zhang G, Valdes A, Aviv A, Spector TD, Atkins JL (2007). Twins, telomeres and aging.

2006

Stubbe JH, Boomsma DI, Vink JM, Cornes BK, Martin NG, Skytthe A, Kyvik KO, Rose RJ, Kujala UM, Kaprio J, et al (2006). Genetic Influences on Exercise Participation in 37.051 Twin Pairs from Seven Countries. PLoS ONE, 1(1), e22-e22. Full text.
Paul SN, Kato BS, Hunkin JL, Vivekanandan S, Spector TD, Fields KB (2006). The Big Finger: the second to fourth digit ratio is a predictor of sporting ability in women. Commentary. British Journal of Sports Medicine, 40(12), 981-983.
Cherkas LF, Aviv A, Valdes AM, Hunkin JL, Gardner JP, Surdulescu GL, Kimura M, Spector TD (2006). The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell, 5(5), 361-365.

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Teaching

Undergraduate 

  • BMBS Research Special Study Unit Provider - Genetic and Environmental Influences on Common Diseases
  • BSc Medical Sciences - Professional Training Year provider and Final Year Project supervisor

Postgraduate 

  • Master of Public Health - HPDM121 Epidemiology (module co-lead)
  • Master of Public Health academic tutor
  • MSc Genomic Medicine - Research Project Supervisor
  • GW4 BioMed MRC Doctoral Training Partnership – online tutor

PhD supervision

  • Lucy Banfield. The impact of the inherited iron overload disorder, haemochromatosis, on the musculoskeletal system in UK Biobank

 

Modules

2021/22


Supervision / Group

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