Philippa Wells
Postdoctoral Research Fellow
P.Wells5@exeter.ac.uk
RILD Building
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK
Overview
Philippa is a Postdoctoral Research Fellow at the University of Exeter Medical School in Jonathon Mill’s group, researching epigenomic changes through the life-course. Prior to this she investigated epigenomic changes in Alzheimer’s disease, and systemic metabolites in Alzheimer’s disease with Alexi Nott’s and Paul Elliot’s groups at Imperial College London. She completed her PhD in Genetic Epidemiology, researching genetic factors and the microbiome in rheumatoid arthritis in early 2021, with the Department of Twin Research at King’s College London.
She obtained her degree, BSc (Hons.) Medical Sciences from the University of Exeter in 2016, during which she undertook a research year at the University of Bristol and the Bristol Brain Bank investigating the role of the renin angiotensin system in Alzheimer’s disease. She has a background in bioinformatics and biology, and is interested in epigenomics changes in health and disease.
Qualifications
- PhD Genetic Epidemiology, King’s College London 2021
- BSc (Hons.) Medical Sciences, University of Exeter 2016
Publications
Journal articles
Delanote J, Correa Rojo A, Wells PM, Steves CJ, Ertaylan G (2024). Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study. SCIENTIFIC REPORTS, 14(1). Author URL.
Danckert NP, Freidin MB, Granville Smith I, Wells PM, Naeini MK, Visconti A, Compte R, Macgregor A, Williams FMK (2024). Treatment response in rheumatoid arthritis is predicted by the microbiome: a large observational study in UK DMARD-naive patients. RHEUMATOLOGY Author URL.
Kurushima Y, Wells PM, Bowyer RCE, Zoheir N, Doran S, Richardson JP, Sprockett DD, Relman DA, Steves CJ, Nibali L, et al (2023). Host Genotype Links to Salivary and Gut Microbiota by Periodontal Status. JOURNAL OF DENTAL RESEARCH, 102(2), 146-156. Author URL.
Stoll ML, Sawhney H, Wells PM, Sternes PR, Reveille JD, Morrow CD, Steves CJ, Brown MA, Gensler LS (2023). The faecal microbiota is distinct in HLA-B27+ankylosing spondylitis patients <i>versus</i> HLA-B27+healthy controls. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, 41(5), 1096-1104. Author URL.
Christiansen C, Tomlinson M, Eliot M, Nilsson E, Costeira R, Xia Y, Villicaña S, Mompeo O, Wells P, Castillo-Fernandez J, et al (2022). Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers. Genome Med, 14(1). Abstract. Author URL.
Granville Smith I, Danckert NP, Freidin MB, Wells P, Marchesi JR, Williams FMK (2022). Evidence for infection in intervertebral disc degeneration: a systematic review. Eur Spine J, 31(2), 414-430. Abstract. Author URL.
Wells PM, Sprockett DD, Bowyer RCE, Kurushima Y, Relman DA, Williams FMK, Steves CJ (2022). Influential factors of saliva microbiota composition. SCIENTIFIC REPORTS, 12(1). Author URL.
Bowyer RCE, Twohig-Bennett C, Coombes E, Wells PM, Spector TD, Jones AP, Steves CJ (2022). Microbiota composition is moderately associated with greenspace composition in a UK cohort of twins. SCIENCE OF THE TOTAL ENVIRONMENT, 813 Author URL.
Freidin MB, Stalteri MA, Wells PM, Lachance G, Baleanu A-F, Bowyer RCE, Kurilshikov A, Zhernakova A, Steves CJ, Williams FMK, et al (2021). An association between chronic widespread pain and the gut microbiome. RHEUMATOLOGY, 60(8), 3727-3737. Author URL.
Nogal A, Louca P, Zhang X, Wells PM, Steves CJ, Spector TD, Falchi M, Valdes AM, Menni C (2021). Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat. FRONTIERS IN MICROBIOLOGY, 12 Author URL.
Louca P, Nogal A, Wells PM, Asnicar F, Wolf J, Steves CJ, Spector TD, Segata N, Berry SE, Valdes AM, et al (2021). Gutmicrobiome diversity and composition is associated with hypertension in women. JOURNAL OF HYPERTENSION, 39(9), 1810-1816. Author URL.
Zouiouich S, Loftfield E, Huybrechts I, Viallon V, Louca P, Vogtmann E, Wells PM, Steves CJ, Herzig K-H, Menni C, et al (2021). Markers of metabolic health and gut microbiome diversity: findings from two population-based cohort studies. DIABETOLOGIA, 64(8), 1749-1759. Author URL.
Cox NJ, Bowyer RCE, Lochlainn MN, Wells PM, Roberts HC, Steves CJ (2021). The composition of the gut microbiome differs among community dwelling older people with good and poor appetite. JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, 12(2), 368-377. Author URL.
Bowyer RCE, Schillereff DN, Jackson MA, Le Roy C, Wells PM, Spector TD, Steves CJ (2020). Associations between UK tap water and gut microbiota composition suggest the gut microbiome as a potential mediator of health differences linked to water quality. SCIENCE OF THE TOTAL ENVIRONMENT, 739 Author URL.
Wells PM, Adebayo AS, Bowyer RCE, Freidin MB, Finckh A, Strowig T, Lesker TR, Alpizar-Rodriguez D, Gilbert B, Kirkham B, et al (2020). Associations between gut microbiota and genetic risk for rheumatoid arthritis in the absence of disease: a cross-sectional study. LANCET RHEUMATOLOGY, 2(7), E418-E427. Author URL.
Fabre MA, McKerrell T, Zwiebel M, Vijayabaskar MS, Park N, Wells PM, Rad R, Deloukas P, Small K, Steves CJ, et al (2020). Concordance for clonal hematopoiesis is limited in elderly twins. BLOOD, 135(4), 269-273. Author URL.
Wells PM, Doores KJ, Couvreur S, Nunez RM, Seow J, Graham C, Acors S, Kouphou N, Neil SJD, Tedder RS, et al (2020). Estimates of the rate of infection and asymptomatic COVID-19 disease in a population sample from SE England. JOURNAL OF INFECTION, 81(6), 931-936. Author URL.
Nag A, Kurushima Y, Bowyer RCE, Wells PM, Weiss S, Pietzner M, Kocher T, Raffler J, Voelker U, Mangino M, et al (2020). Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels. HUMAN MOLECULAR GENETICS, 29(5), 864-875. Author URL.
Ni Y, Yu G, Chen H, Deng Y, Wells PM, Steves CJ, Ju F, Fu J (2020). M<SUP>2</SUP>IA: a web server for microbiome and metabolome integrative analysis. BIOINFORMATICS, 36(11), 3493-3498. Author URL.
Le Roy CI, Wells PM, Si J, Raes J, Bell JT, Spector TD (2020). Red Wine Consumption Associated with Increased Gut Microbiota α-Diversity in 3 Independent Cohorts. GASTROENTEROLOGY, 158(1), 270-+. Author URL.
Adebayo AS, Ackermann G, Bowyer RCE, Wells PM, Humphreys G, Knight R, Spector TD, Steves CJ (2020). The Urinary Tract Microbiome in Older Women Exhibits Host Genetic and Environmental Influences. CELL HOST & MICROBE, 28(2), 298-+. Author URL.
Wells PM, Williams FMK, Matey-Hernandez ML, Menni C, Steves CJ (2019). RA and the microbiome: do host genetic factors provide the link?. JOURNAL OF AUTOIMMUNITY, 99, 104-115. Author URL.
Conferences
Zazzara MB, Wells PM, Bowyer RCE, Lochlainn MN, Thompson EJ, Penfold RS, Steves CJ (2021). PERIODONTAL HEALTH AND SARCOPENIA: CROSS-SECTIONAL EVIDENCE FROM a COHORT OF 2040 TWIN VOLUNTEERS. Author URL.
