Key publications
Wu Y-T, Fratiglioni L, Matthews FE, Lobo A, Breteler MMB, Skoog I, Brayne C (2016). Dementia in western Europe: epidemiological evidence and implications for policy making. The Lancet Neurology, 15(1), 116-124.
Wu Y-T, Prina AM, Jones AP, Barnes LE, Matthews FE, Brayne C (2015). Community environment, cognitive impairment and dementia in later life: results from the Cognitive Function and Ageing Study. Age and Ageing, 44(6), 1005-1011.
Wu Y-T, Prina AM, Jones A, Matthews FE, Brayne C (2015). Older people, the natural environment and common mental disorders: cross-sectional results from the Cognitive Function and Ageing Study. BMJ Open, 5(9), e007936-e007936.
Wu Y, Lee H, Norton S, Prina AM, Fleming J, Matthews FE, Brayne C (2014). Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: a meta‐analysis. International Journal of Geriatric Psychiatry, 29(12), 1212-1220.
Wu Y-T, Prina AM, Brayne C (2014). The association between community environment and cognitive function: a systematic review. Social Psychiatry and Psychiatric Epidemiology, 50(3), 351-362.
Wu Y-T, Lee H-Y, Norton S, Chen C, Chen H, He C, Fleming J, Matthews FE, Brayne C (2013). Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: a Systematic Review and Meta-Analysis. PLoS ONE, 8(6), e66252-e66252.
Publications by category
Journal articles
Opdebeeck C, Matthews FE, Wu Y-T, Woods R, Brayne C, Clare L (In Press). Cognitive reserve as a moderator of the negative association between mood and cognition: evidence from a population-representative cohort.
Psychological Medicine Full text.
Wu Y-T, Luben R, Jones A (In Press). Dog ownership supports the maintenance of physical activity during poor weather in older English adults: cross-sectional results from the EPIC Norfolk cohort.
Journal of Epidemiology and Community Health Full text.
Wu Y-T, Prina AM, Jones A, Barnes L, Matthews FE, Brayne C (In Press). Micro-scale environment and mental health in later life: results from the Cognitive Function and Ageing Study II (CFAS II).
Journal of Affective Disorders Full text.
Wu Y-T, Ali G-C, Guerchet M, Prina AM, Chan KY, Prince M, Brayne C (In Press). Prevalence of dementia in mainland China, Hong Kong, and Taiwan: an updated systematic review and meta-analysis.
International Journal of Epidemiology Full text.
Wu Y-T, Prina AM, Jones A, Matthews FE, Brayne C (In Press). The built environment and cognitive disorders: results from the Cognitive Function and Ageing Study II.
American Journal of Preventive Medicine Full text.
Clare L, Wu Y-T, Teale JC, MacLeod C, Matthews F, Brayne C, Woods B, CFAS-Wales study team (2017). Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: a cross-sectional study.
PLoS Med,
14(3).
Abstract:
Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: a cross-sectional study.
BACKGROUND: Potentially modifiable lifestyle factors may influence cognitive health in later life and offer potential to reduce the risk of cognitive decline and dementia. The concept of cognitive reserve has been proposed as a mechanism to explain individual differences in rates of cognitive decline, but its potential role as a mediating pathway has seldom been explored using data from large epidemiological studies. We explored the mediating effect of cognitive reserve on the cross-sectional association between lifestyle factors and cognitive function in later life using data from a population-based cohort of healthy older people. METHODS AND FINDINGS: We analysed data from 2,315 cognitively healthy participants aged 65 y and over in the Cognitive Function and Ageing Study Wales (CFAS-Wales) cohort collected in 2011-2013. Linear regression modelling was used to investigate the overall associations between five lifestyle factors-cognitive and social activity, physical activity, diet, alcohol consumption, and smoking-and cognition, adjusting for demographic factors and chronic conditions. Mediation analysis tested for indirect effects of the lifestyle factors on cognition via cognitive reserve. After controlling for age, gender, and the presence of chronic conditions, cognitive and social activity, physical activity, healthy diet, and light-to-moderate alcohol consumption were positively associated with cognitive function, together accounting for 20% (95% CI 17%-23%) of variance in cognitive test scores. Cognitive reserve was an important mediator of this association, with indirect effects via cognitive reserve contributing 21% (95% CI 15%-27%) of the overall effect on cognition. The main limitations of the study derive from the cross-sectional nature of the data and the challenges of accurately measuring the latent construct of cognitive reserve. CONCLUSIONS: Cross-sectional associations support the view that enhancing cognitive reserve may benefit cognition, and maintenance of cognitive health may be supported by a healthy and active lifestyle, in later life.
Abstract.
Author URL.
Full text.
Wu Y-T, Beiser AS, Breteler M, Fratiglioni L, Helmer C, Hendrie H, Honda H, Ikram MA, Langa KM, Lobo A, et al (2017). Trends in the prevalence and incidence of dementia: a review of current evidence.
Nature Reviews Neurology Full text.
Wu Y-T, Luben R, Wareham N, Griffin S, Jones A (2017). Weather, Day Length and Physical Activity in Older Adults:
Cross-Sectional Results from the European Prospective Investigation into
Cancer and Nutrition (EPIC) Norfolk Cohort.
PLoS ONE Full text.
Stubbs B, Wu Y-T, Prina AM, Leng Y, Cosco TD (2016). A population study of the association between sleep disturbance and suicidal behaviour in people with mental illness. Journal of Psychiatric Research, 82, 149-154.
Wu Y-T, Fratiglioni L, Matthews FE, Lobo A, Breteler MMB, Skoog I, Brayne C (2016). Dementia in western Europe: epidemiological evidence and implications for policy making. The Lancet Neurology, 15(1), 116-124.
Soysal P, Stubbs B, Lucato P, Luchini C, Solmi M, Peluso R, Sergi G, Isik AT, Manzato E, Maggi S, et al (2016). Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Research Reviews, 31, 1-8.
Wu Y-T, Prina AM, Jones AP, Barnes LE, Matthews FE, Brayne C (2016). Land use mix and five-year mortality in later life: results from the Cognitive Function and Ageing Study.
Health & Place,
38, 54-60.
Full text.
Wu Y-T, Teale J, Matthews F, Brayne C, Woods R, Clare L (2016). Lifestyle factors, cognitive reserve, and cognitive function: results from the Cognitive Function and Ageing Study Wales, a population-based cohort.
Lancet, The,
388, S114-S114.
Full text.
Wu Y-T, Lee H-Y (2016). National Health Insurance database in Taiwan: a resource or obstacle for health research?.
European Journal of Internal Medicine,
31, e9-e10.
Full text.
Wu Y-T, Jones N, van Sluijs E, Griffin S, Wareham N, Jones A (2016). Perceived and objectively measured environmental correlates of domain specific physical activity in older English adults.
Journal of Aging and Physical Activity,
24 Full text.
Brayne C, Wu Y-T (2016). Preventing both stroke and dementia – Authors' reply. The Lancet Neurology, 15(7), 659-659.
Prince M, Ali G-C, Guerchet M, Prina AM, Albanese E, Wu Y-T (2016). Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimer's Research & Therapy, 8(1).
Cosco TD, Stubbs B, Prina AM, Wu Y-T (2016). Religiosity and suicidal behaviour in the National Survey of American Life. Acta Psychiatrica Scandinavica, 134(2), 183-184.
Wimo A, Guerchet M, Ali G-C, Wu Y-T, Prina AM, Winblad B, Jönsson L, Liu Z, Prince M (2016). The worldwide costs of dementia 2015 and comparisons with 2010. Alzheimer's & Dementia, 13(1), 1-7.
Wu Y-T, Luben R, Wareham N, Griffin S, Jones A (2016). Weather, day length and physical activity in older adults: Results from the EPIC Norfolk cohort. European Journal of Public Health
Wu Y-T, Prina AM, Jones AP, Barnes LE, Matthews FE, Brayne C (2015). Community environment, cognitive impairment and dementia in later life: results from the Cognitive Function and Ageing Study. Age and Ageing, 44(6), 1005-1011.
Wu Y-T, Grant WB, Prina AM, Lee HY, Brayne C (2015). Nutrition and the prevalence of dementia in mainland China, Hong Kong, and Taiwan: an ecological study. Journal of Alzheimer's disease : JAD, 44(4), 1099-1106.
Wu Y-T, Prina AM, Jones A, Matthews FE, Brayne C (2015). Older people, the natural environment and common mental disorders: cross-sectional results from the Cognitive Function and Ageing Study. BMJ Open, 5(9), e007936-e007936.
Wu Y, Brayne C, Matthews FE (2015). Prevalence of dementia in East Asia: a synthetic review of time trends. International Journal of Geriatric Psychiatry, 30(8), 793-801.
Wu Y-T, Prina AM, Barnes LE, Matthews FE, Brayne C (2015). Relocation at older age: results from the Cognitive Function and Ageing Study. Journal of Public Health, 37(3), 480-487.
Wu Y-T, Prina AM, Brayne C (2014). Age-friendly cities and environments: an investigation of the living environment of older people in England based on the MRC Cognitive Function and Ageing Study II. The Lancet, 384, S89-S89.
Wu Y-T, Nash P, Barnes LE, Minett T, Matthews FE, Jones A, Brayne C (2014). Assessing environmental features related to mental health: a reliability study of visual streetscape images. BMC Public Health, 14(1).
Wu Y-T, Matthews FE, Brayne C (2014). Dementia: Time trends and policy responses. Maturitas, 79(2), 191-195.
Wu Y, Lee H, Norton S, Prina AM, Fleming J, Matthews FE, Brayne C (2014). Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: a meta‐analysis. International Journal of Geriatric Psychiatry, 29(12), 1212-1220.
Martin S, Chinnock P, Perales J, Lee H-Y, Lee CY, Wu Y-T, Mavrodaris A (2014). Self-management interventions for people living with HIV/AIDS. Cochrane Database of Systematic Reviews(9).
Wu Y-T, Prina AM, Brayne C (2014). The association between community environment and cognitive function: a systematic review. Social Psychiatry and Psychiatric Epidemiology, 50(3), 351-362.
Wu Y-T, Lee H-Y, Norton S, Chen C, Chen H, He C, Fleming J, Matthews FE, Brayne C (2013). Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: a Systematic Review and Meta-Analysis. PLoS ONE, 8(6), e66252-e66252.
Wang H-LS, Yu R, Wu Y-T, Lee W-Y, Lin M-F, Chen C-Y, Shen E-Y (2013). The Changes of Cerebral Morphology Related to Aging in Taiwanese Population. PLoS ONE, 8(1), e55241-e55241.
Conferences
Wu Y-T, Luben R, Warham N, Griffin S, Jones A (2016). Weather, day length and physical activity in older adults: Results from the EPIC Norfolk cohort. European Public Health Conference. 9th - 12th Nov 2016.
Reports
Prince M, Wimo A, Guerchet M, Ali G-C, Wu Y-T, Prina AM (2015). World Alzheimer Report 2015: the Global Impact of Dementia: an analysis of prevalence, incidence, cost and trends.
Internet publications
Wu Y-T (2015). Calling for global action against dementia: the missing voice of low- and middle-income countries.
Web link.
Wu Y-T, Brayne C (2015). Despite the headlines, dementia epidemic may not actually be getting worse.
Web link.
Publications by year
In Press
Opdebeeck C, Matthews FE, Wu Y-T, Woods R, Brayne C, Clare L (In Press). Cognitive reserve as a moderator of the negative association between mood and cognition: evidence from a population-representative cohort.
Psychological Medicine Full text.
Wu Y-T, Luben R, Jones A (In Press). Dog ownership supports the maintenance of physical activity during poor weather in older English adults: cross-sectional results from the EPIC Norfolk cohort.
Journal of Epidemiology and Community Health Full text.
Wu Y-T, Prina AM, Jones A, Barnes L, Matthews FE, Brayne C (In Press). Micro-scale environment and mental health in later life: results from the Cognitive Function and Ageing Study II (CFAS II).
Journal of Affective Disorders Full text.
Wu Y-T, Ali G-C, Guerchet M, Prina AM, Chan KY, Prince M, Brayne C (In Press). Prevalence of dementia in mainland China, Hong Kong, and Taiwan: an updated systematic review and meta-analysis.
International Journal of Epidemiology Full text.
Wu Y-T, Prina AM, Jones A, Matthews FE, Brayne C (In Press). The built environment and cognitive disorders: results from the Cognitive Function and Ageing Study II.
American Journal of Preventive Medicine Full text.
2017
Clare L, Wu Y-T, Teale JC, MacLeod C, Matthews F, Brayne C, Woods B, CFAS-Wales study team (2017). Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: a cross-sectional study.
PLoS Med,
14(3).
Abstract:
Potentially modifiable lifestyle factors, cognitive reserve, and cognitive function in later life: a cross-sectional study.
BACKGROUND: Potentially modifiable lifestyle factors may influence cognitive health in later life and offer potential to reduce the risk of cognitive decline and dementia. The concept of cognitive reserve has been proposed as a mechanism to explain individual differences in rates of cognitive decline, but its potential role as a mediating pathway has seldom been explored using data from large epidemiological studies. We explored the mediating effect of cognitive reserve on the cross-sectional association between lifestyle factors and cognitive function in later life using data from a population-based cohort of healthy older people. METHODS AND FINDINGS: We analysed data from 2,315 cognitively healthy participants aged 65 y and over in the Cognitive Function and Ageing Study Wales (CFAS-Wales) cohort collected in 2011-2013. Linear regression modelling was used to investigate the overall associations between five lifestyle factors-cognitive and social activity, physical activity, diet, alcohol consumption, and smoking-and cognition, adjusting for demographic factors and chronic conditions. Mediation analysis tested for indirect effects of the lifestyle factors on cognition via cognitive reserve. After controlling for age, gender, and the presence of chronic conditions, cognitive and social activity, physical activity, healthy diet, and light-to-moderate alcohol consumption were positively associated with cognitive function, together accounting for 20% (95% CI 17%-23%) of variance in cognitive test scores. Cognitive reserve was an important mediator of this association, with indirect effects via cognitive reserve contributing 21% (95% CI 15%-27%) of the overall effect on cognition. The main limitations of the study derive from the cross-sectional nature of the data and the challenges of accurately measuring the latent construct of cognitive reserve. CONCLUSIONS: Cross-sectional associations support the view that enhancing cognitive reserve may benefit cognition, and maintenance of cognitive health may be supported by a healthy and active lifestyle, in later life.
Abstract.
Author URL.
Full text.
Wu Y-T, Beiser AS, Breteler M, Fratiglioni L, Helmer C, Hendrie H, Honda H, Ikram MA, Langa KM, Lobo A, et al (2017). Trends in the prevalence and incidence of dementia: a review of current evidence.
Nature Reviews Neurology Full text.
Wu Y-T, Luben R, Wareham N, Griffin S, Jones A (2017). Weather, Day Length and Physical Activity in Older Adults:
Cross-Sectional Results from the European Prospective Investigation into
Cancer and Nutrition (EPIC) Norfolk Cohort.
PLoS ONE Full text.
2016
Stubbs B, Wu Y-T, Prina AM, Leng Y, Cosco TD (2016). A population study of the association between sleep disturbance and suicidal behaviour in people with mental illness. Journal of Psychiatric Research, 82, 149-154.
Wu Y-T, Fratiglioni L, Matthews FE, Lobo A, Breteler MMB, Skoog I, Brayne C (2016). Dementia in western Europe: epidemiological evidence and implications for policy making. The Lancet Neurology, 15(1), 116-124.
Soysal P, Stubbs B, Lucato P, Luchini C, Solmi M, Peluso R, Sergi G, Isik AT, Manzato E, Maggi S, et al (2016). Inflammation and frailty in the elderly: a systematic review and meta-analysis. Ageing Research Reviews, 31, 1-8.
Wu Y-T, Prina AM, Jones AP, Barnes LE, Matthews FE, Brayne C (2016). Land use mix and five-year mortality in later life: results from the Cognitive Function and Ageing Study.
Health & Place,
38, 54-60.
Full text.
Wu Y-T, Teale J, Matthews F, Brayne C, Woods R, Clare L (2016). Lifestyle factors, cognitive reserve, and cognitive function: results from the Cognitive Function and Ageing Study Wales, a population-based cohort.
Lancet, The,
388, S114-S114.
Full text.
Wu Y-T, Lee H-Y (2016). National Health Insurance database in Taiwan: a resource or obstacle for health research?.
European Journal of Internal Medicine,
31, e9-e10.
Full text.
Wu Y-T, Jones N, van Sluijs E, Griffin S, Wareham N, Jones A (2016). Perceived and objectively measured environmental correlates of domain specific physical activity in older English adults.
Journal of Aging and Physical Activity,
24 Full text.
Brayne C, Wu Y-T (2016). Preventing both stroke and dementia – Authors' reply. The Lancet Neurology, 15(7), 659-659.
Prince M, Ali G-C, Guerchet M, Prina AM, Albanese E, Wu Y-T (2016). Recent global trends in the prevalence and incidence of dementia, and survival with dementia. Alzheimer's Research & Therapy, 8(1).
Cosco TD, Stubbs B, Prina AM, Wu Y-T (2016). Religiosity and suicidal behaviour in the National Survey of American Life. Acta Psychiatrica Scandinavica, 134(2), 183-184.
Wimo A, Guerchet M, Ali G-C, Wu Y-T, Prina AM, Winblad B, Jönsson L, Liu Z, Prince M (2016). The worldwide costs of dementia 2015 and comparisons with 2010. Alzheimer's & Dementia, 13(1), 1-7.
Wu Y-T, Luben R, Wareham N, Griffin S, Jones A (2016). Weather, day length and physical activity in older adults: Results from the EPIC Norfolk cohort. European Journal of Public Health
Wu Y-T, Luben R, Warham N, Griffin S, Jones A (2016). Weather, day length and physical activity in older adults: Results from the EPIC Norfolk cohort. European Public Health Conference. 9th - 12th Nov 2016.
2015
Wu Y-T (2015). Calling for global action against dementia: the missing voice of low- and middle-income countries.
Web link.
Wu Y-T, Prina AM, Jones AP, Barnes LE, Matthews FE, Brayne C (2015). Community environment, cognitive impairment and dementia in later life: results from the Cognitive Function and Ageing Study. Age and Ageing, 44(6), 1005-1011.
Wu Y-T, Brayne C (2015). Despite the headlines, dementia epidemic may not actually be getting worse.
Web link.
Wu Y-T, Grant WB, Prina AM, Lee HY, Brayne C (2015). Nutrition and the prevalence of dementia in mainland China, Hong Kong, and Taiwan: an ecological study. Journal of Alzheimer's disease : JAD, 44(4), 1099-1106.
Wu Y-T, Prina AM, Jones A, Matthews FE, Brayne C (2015). Older people, the natural environment and common mental disorders: cross-sectional results from the Cognitive Function and Ageing Study. BMJ Open, 5(9), e007936-e007936.
Wu Y, Brayne C, Matthews FE (2015). Prevalence of dementia in East Asia: a synthetic review of time trends. International Journal of Geriatric Psychiatry, 30(8), 793-801.
Wu Y-T, Prina AM, Barnes LE, Matthews FE, Brayne C (2015). Relocation at older age: results from the Cognitive Function and Ageing Study. Journal of Public Health, 37(3), 480-487.
Prince M, Wimo A, Guerchet M, Ali G-C, Wu Y-T, Prina AM (2015). World Alzheimer Report 2015: the Global Impact of Dementia: an analysis of prevalence, incidence, cost and trends.
2014
Wu Y-T, Prina AM, Brayne C (2014). Age-friendly cities and environments: an investigation of the living environment of older people in England based on the MRC Cognitive Function and Ageing Study II. The Lancet, 384, S89-S89.
Wu Y-T, Nash P, Barnes LE, Minett T, Matthews FE, Jones A, Brayne C (2014). Assessing environmental features related to mental health: a reliability study of visual streetscape images. BMC Public Health, 14(1).
Wu Y-T, Matthews FE, Brayne C (2014). Dementia: Time trends and policy responses. Maturitas, 79(2), 191-195.
Wu Y, Lee H, Norton S, Prina AM, Fleming J, Matthews FE, Brayne C (2014). Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: a meta‐analysis. International Journal of Geriatric Psychiatry, 29(12), 1212-1220.
Martin S, Chinnock P, Perales J, Lee H-Y, Lee CY, Wu Y-T, Mavrodaris A (2014). Self-management interventions for people living with HIV/AIDS. Cochrane Database of Systematic Reviews(9).
Wu Y-T, Prina AM, Brayne C (2014). The association between community environment and cognitive function: a systematic review. Social Psychiatry and Psychiatric Epidemiology, 50(3), 351-362.
2013
Wu Y-T, Lee H-Y, Norton S, Chen C, Chen H, He C, Fleming J, Matthews FE, Brayne C (2013). Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: a Systematic Review and Meta-Analysis. PLoS ONE, 8(6), e66252-e66252.
Wang H-LS, Yu R, Wu Y-T, Lee W-Y, Lin M-F, Chen C-Y, Shen E-Y (2013). The Changes of Cerebral Morphology Related to Aging in Taiwanese Population. PLoS ONE, 8(1), e55241-e55241.