COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Valentina Mosienko

Dr Valentina Mosienko

Lecturer

 01392 72 3529

 Hatherly D9

 

Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

Overview

Dr Valentina Mosienko is a neuroscientist with a background in behavior neuroscience, and molecular and glial biology. In her group, they investigate causes, mechanisms and therapeutic targets in neuropsychiatric disorders. The current focus of her research is on non-neuronal mechanisms underlying depression through immune cells of the brain, astrocytes and microglia.

Follow on Twitter @Dr_VMosienko https://twitter.com/Dr_VMosienko

Selected invited talks

  • 2018: Invited speaker,  University College Cork (Ireland)
  • 2016: Invited speaker, Max-Delbrueck Center for Molecular Medicine (Germany)
  • 2013: Symposium speaker, 10th German Neuroscience society meeting (Germany)
  • 2010: Symposium speaker, 9th International Serotonin Research meeting (Canada)

Honours and Awards

  • 2020: University of Exeter Above and Beyond Award for Impact
  • 2020: University of Exeter Above and Beyond Award for Collaboration
  • 2019: University of Exeter Above and Beyond Award for Collaboration
  • 2016: Best poster award, Volga Neuroscience conference (Russia)

Professional Memberships

  • German Neuroscience Society (2008-)
  • International Society for Serotonin Research (2008-2014)
  • British Neuroscience Association (2017-)
  • Physiological society (2018-)
  • British Society for Neuroendocrinology (2018-)

Qualifications

  • PhD, summa cum laude – Humboldt University Berlin, 2013
  • Diploma – Belarusian State University, 2008

Career

Dr Mosienko completed her first degree in Biology at the Belarusian State University (Belarus) before obtaining a German Academic Exchange Service (DAAD) fellowship to undertake doctoral studies at the Max-Delbrueck Center for Molecular Medicine (MDC, Germany). She earned her PhD (summa cum laude) from the Humboldt University Berlin (Germany) and went on to take up postdoctoral positions first at the MDC and then at the University of Bristol before her recent appointment as a Lecturer at the University of Exeter Medical School.

Research

Research interests

If you are an undergraduate or postgraduate student or postdoctoral researcher and interested in working in the Mosienko's laboratory, please, do no hesitate and get in touch with Dr Valentina Mosienko (email: v.mosienko@exeter.ac.uk).  

Current Lab Members 

  • Abby Moroney (2020/21, Master's student)
  • Daisy Stevens (2020/21 internal PTY student)
  • Annabel Smith (2020/21 internal FY student)
  • Eugenia Davidson (2020/21 internal FY student)

Alumnis

  • Tom Ridge (2019/20 internal FY student)
  • Rushant Rui (2019/20 internal FY student)
  • Melin Hasan (2018/19 internal FY studentt)
  • Mary Newland (2018/19 internal FY student)

Co-supervisor

  • Katy Murrall (2017-2021, PhD student)

Research projects

Research grants/projects

Current

  • 2020-2025: the Medical Research Council Career Development Award "Astrocyte mechanisms in depression"
  • 2020-2022: the Academy of Medical Sciences Springboard Award "Novel mechanisms in depression: investigating the effects of astrocytic lactate on emotional behaviour"
  • 2020-2021: Wellcome Trust Institutional Strategic Support Award "Identifying molecular markers of depression in astrocytes", co-PI Dr Ryan Ames, 
  • 2019-2021: Northcott Devon Medical Foundation grant "Dissecting antidepressant mechanisms of astrocytic lactate release", co-PI Dr Craig Beall

Previous

  • 2014: Federation of European Neuroscience (FENS) travel grant to attend 9th FENS Forum of Neuroscience (Italy)
  • 2013: Federation of European Neuroscience (FENS) exchange grant “Optogenetics as a tool for studying the serotonergic system”
  • 2011: European Molecular Biology Organization (EMBO) travel grant to attend practical course “Mouse phenotyping” (Switzerland)
  • 2013: German neuroscience society (GNS) travel grant to attend 10th meeting of GNS (Germany)
  • 2010: NIH travel grant to participate in 9th meeting of the International Society for Serotonin Research (Canada)
  • 2008-2014: German Academic Exchange Service (DAAD) PhD fellowship 

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Gebhardt C, Mosienko V, Alenina N, Albrecht D (2019). Priming of LTP in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin. Hippocampus, 29(7), 610-618. Abstract.  Author URL.
Matthes S, Mosienko V, Popova E, Rivalan M, Bader M, Alenina N (2019). Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. ACS Chem Neurosci, 10(7), 3207-3217. Abstract.  Author URL.
Hosford PS, Mosienko V, Kishi K, Jurisic G, Seuwen K, Kinzel B, Ludwig MG, Wells JA, Christie IN, Koolen L, et al (2018). CNS distribution, signalling properties and central effects of G-protein coupled receptor 4. Neuropharmacology, 138, 381-392. Abstract.  Author URL.  Full text.
Klempin F, Mosienko V, Matthes S, Villela DC, Todiras M, Penninger JM, Bader M, Santos RAS, Alenina N (2018). Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. Cell Mol Life Sci, 75(19), 3625-3634. Abstract.  Author URL.  Full text.
Liu B, Mosienko V, Vaccari Cardoso B, Prokudina D, Huentelman MJ, Teschemacher AG, Kasparov S (2018). Glio- and neuroprotection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37. Glia Abstract.  Full text.
Mosienko V, Rasooli-Nejad S, Kishi K, De Both M, Jane D, Huentelman M, Kasparov S, Teschemacher A (2018). Putative Receptors Underpinning l-Lactate Signalling in Locus Coeruleus. Neuroglia, 1(2), 365-380. Abstract.
Mosienko V, Chang AJ, Alenina N, Teschemacher AG, Kasparov S (2017). Rodents and humans are able to detect the odour of L-Lactate. PLoS One, 12(5). Abstract.  Author URL.  Full text.
Beis D, Holzwarth K, Flinders M, Mosienko V, Bader M, Wöhr M, Alenina N (2016). Correction to 'Brain serotonin deficiency leads to social communication deficits in mice'. Biol Lett, 12(1). Author URL.
Motta-Santos D, Dos Santos RAS, Oliveira M, Qadri F, Poglitsch M, Mosienko V, Kappes Becker L, Campagnole-Santos MJ, M Penninger J, Alenina N, et al (2016). Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise. Hypertens Res, 39(7), 506-512. Abstract.  Author URL.
Kronenberg G, Mosienko V, Gertz K, Alenina N, Hellweg R, Klempin F (2016). Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. Eur Arch Psychiatry Clin Neurosci, 266(3), 281-284. Abstract.  Author URL.
Hainer C, Mosienko V, Koutsikou S, Crook JJ, Gloss B, Kasparov S, Lumb BM, Alenina N (2015). Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry. ACS Chem Neurosci, 6(7), 1116-1129. Abstract.  Author URL.
Marina N, Ang R, Machhada A, Kasymov V, Karagiannis A, Hosford PS, Mosienko V, Teschemacher AG, Vihko P, Paton JFR, et al (2015). Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. Hypertension, 65(4), 775-783. Abstract.  Author URL.
Mosienko V, Teschemacher AG, Kasparov S (2015). Is L-lactate a novel signaling molecule in the brain?. J Cereb Blood Flow Metab, 35(7), 1069-1075. Abstract.  Author URL.
Mosienko V, Beis D, Pasqualetti M, Waider J, Matthes S, Qadri F, Bader M, Alenina N (2015). Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis. Behav Brain Res, 277, 78-88. Abstract.  Author URL.
Mosienko V, Beis D, Alenina N, Wöhr M (2015). Reduced isolation-induced pup ultrasonic communication in mouse pups lacking brain serotonin. Mol Autism, 6 Abstract.  Author URL.
Mosienko V, Matthes S, Hirth N, Beis D, Flinders M, Bader M, Hansson AC, Alenina N (2014). Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology, 85, 73-80. Abstract.  Author URL.
Narboux-Nême N, Angenard G, Mosienko V, Klempin F, Pitychoutis PM, Deneris E, Bader M, Giros B, Alenina N, Gaspar P, et al (2013). Postnatal growth defects in mice with constitutive depletion of central serotonin. ACS Chem Neurosci, 4(1), 171-181. Abstract.  Author URL.
Klempin F, Beis D, Mosienko V, Kempermann G, Bader M, Alenina N (2013). Serotonin is required for exercise-induced adult hippocampal neurogenesis. J Neurosci, 33(19), 8270-8275. Abstract.  Author URL.
Mosienko V, Bert B, Beis D, Matthes S, Fink H, Bader M, Alenina N (2012). Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Transl Psychiatry, 2 Abstract.  Author URL.
Liskovykh M, Chuykin I, Ranjan A, Safina D, Popova E, Tolkunova E, Mosienko V, Minina JM, Zhdanova NS, Mullins JJ, et al (2011). Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats. PLoS One, 6(11). Abstract.  Author URL.
Liskovykh MA, Chuĭkin IA, Ranjan A, Popova E, Tolkunova EN, Chechik LL, Malinin AI, Morozova AV, Mosienko V, Bader M, et al (2011). [Genetic manipulation and studying of differentiation properties of rat induced pluripotent stem cells]. Tsitologiia, 53(12), 946-951. Abstract.  Author URL.
Chuykin I, Lapidus I, Popova E, Vilianovich L, Mosienko V, Alenina N, Binas B, Chai G, Bader M, Krivokharchenko A, et al (2010). Characterization of trophoblast and extraembryonic endoderm cell lineages derived from rat preimplantation embryos. PLoS One, 5(3). Abstract.  Author URL.
Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M (2010). Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology, 85(2), 95-109. Abstract.  Author URL.
Alenina N, Kikic D, Todiras M, Mosienko V, Qadri F, Plehm R, Boyé P, Vilianovitch L, Sohr R, Tenner K, et al (2009). Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci U S A, 106(25), 10332-10337. Abstract.  Author URL.

Conferences

Cardoso BV, Mosienko V, Gourine AV, Kasparov S, Teschemacher A (2019). Novel viral vector tools selectively inhibit astrocytic L-lactate release.  Author URL.
Rasooli-Nejad A, Mosienko V, Jane D, Kasparov S, Teschemacher A (2017). Structure-activity studies into lactate-mediated depolarisation and noradrenaline release in the rat Locus Coeruleus.  Author URL.
Santos D, Santos R, Oliveira M, Mosienko V, Plehm R, Todiras M, Qadri F, Poglitsch M, Alenina N, Bader M, et al (2014). Voluntary exercise during 6 weeks induces pathological cardiovascular responses in MAS-deficient mice.  Author URL.
Alenina N, Fishman V, Popova E, Mosienko V, Charpak S, Kasparov S, Bader M (2013). Brain endothelium specific reporter: a novel rat model based on ectopic transgene expression.  Author URL.

Publications by year


2019

Cardoso BV, Mosienko V, Gourine AV, Kasparov S, Teschemacher A (2019). Novel viral vector tools selectively inhibit astrocytic L-lactate release.  Author URL.
Gebhardt C, Mosienko V, Alenina N, Albrecht D (2019). Priming of LTP in amygdala and hippocampus by prior paired pulse facilitation paradigm in mice lacking brain serotonin. Hippocampus, 29(7), 610-618. Abstract.  Author URL.
Matthes S, Mosienko V, Popova E, Rivalan M, Bader M, Alenina N (2019). Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. ACS Chem Neurosci, 10(7), 3207-3217. Abstract.  Author URL.

2018

Hosford PS, Mosienko V, Kishi K, Jurisic G, Seuwen K, Kinzel B, Ludwig MG, Wells JA, Christie IN, Koolen L, et al (2018). CNS distribution, signalling properties and central effects of G-protein coupled receptor 4. Neuropharmacology, 138, 381-392. Abstract.  Author URL.  Full text.
Klempin F, Mosienko V, Matthes S, Villela DC, Todiras M, Penninger JM, Bader M, Santos RAS, Alenina N (2018). Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. Cell Mol Life Sci, 75(19), 3625-3634. Abstract.  Author URL.  Full text.
Liu B, Mosienko V, Vaccari Cardoso B, Prokudina D, Huentelman MJ, Teschemacher AG, Kasparov S (2018). Glio- and neuroprotection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37. Glia Abstract.  Full text.
Mosienko V, Rasooli-Nejad S, Kishi K, De Both M, Jane D, Huentelman M, Kasparov S, Teschemacher A (2018). Putative Receptors Underpinning l-Lactate Signalling in Locus Coeruleus. Neuroglia, 1(2), 365-380. Abstract.

2017

Mosienko V, Chang AJ, Alenina N, Teschemacher AG, Kasparov S (2017). Rodents and humans are able to detect the odour of L-Lactate. PLoS One, 12(5). Abstract.  Author URL.  Full text.
Rasooli-Nejad A, Mosienko V, Jane D, Kasparov S, Teschemacher A (2017). Structure-activity studies into lactate-mediated depolarisation and noradrenaline release in the rat Locus Coeruleus.  Author URL.

2016

Beis D, Holzwarth K, Flinders M, Mosienko V, Bader M, Wöhr M, Alenina N (2016). Correction to 'Brain serotonin deficiency leads to social communication deficits in mice'. Biol Lett, 12(1). Author URL.
Motta-Santos D, Dos Santos RAS, Oliveira M, Qadri F, Poglitsch M, Mosienko V, Kappes Becker L, Campagnole-Santos MJ, M Penninger J, Alenina N, et al (2016). Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise. Hypertens Res, 39(7), 506-512. Abstract.  Author URL.
Kronenberg G, Mosienko V, Gertz K, Alenina N, Hellweg R, Klempin F (2016). Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. Eur Arch Psychiatry Clin Neurosci, 266(3), 281-284. Abstract.  Author URL.

2015

Hainer C, Mosienko V, Koutsikou S, Crook JJ, Gloss B, Kasparov S, Lumb BM, Alenina N (2015). Beyond Gene Inactivation: Evolution of Tools for Analysis of Serotonergic Circuitry. ACS Chem Neurosci, 6(7), 1116-1129. Abstract.  Author URL.
Marina N, Ang R, Machhada A, Kasymov V, Karagiannis A, Hosford PS, Mosienko V, Teschemacher AG, Vihko P, Paton JFR, et al (2015). Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. Hypertension, 65(4), 775-783. Abstract.  Author URL.
Mosienko V, Teschemacher AG, Kasparov S (2015). Is L-lactate a novel signaling molecule in the brain?. J Cereb Blood Flow Metab, 35(7), 1069-1075. Abstract.  Author URL.
Mosienko V, Beis D, Pasqualetti M, Waider J, Matthes S, Qadri F, Bader M, Alenina N (2015). Life without brain serotonin: reevaluation of serotonin function with mice deficient in brain serotonin synthesis. Behav Brain Res, 277, 78-88. Abstract.  Author URL.
Mosienko V, Beis D, Alenina N, Wöhr M (2015). Reduced isolation-induced pup ultrasonic communication in mouse pups lacking brain serotonin. Mol Autism, 6 Abstract.  Author URL.

2014

Mosienko V, Matthes S, Hirth N, Beis D, Flinders M, Bader M, Hansson AC, Alenina N (2014). Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology, 85, 73-80. Abstract.  Author URL.
Santos D, Santos R, Oliveira M, Mosienko V, Plehm R, Todiras M, Qadri F, Poglitsch M, Alenina N, Bader M, et al (2014). Voluntary exercise during 6 weeks induces pathological cardiovascular responses in MAS-deficient mice.  Author URL.

2013

Alenina N, Fishman V, Popova E, Mosienko V, Charpak S, Kasparov S, Bader M (2013). Brain endothelium specific reporter: a novel rat model based on ectopic transgene expression.  Author URL.
Narboux-Nême N, Angenard G, Mosienko V, Klempin F, Pitychoutis PM, Deneris E, Bader M, Giros B, Alenina N, Gaspar P, et al (2013). Postnatal growth defects in mice with constitutive depletion of central serotonin. ACS Chem Neurosci, 4(1), 171-181. Abstract.  Author URL.
Klempin F, Beis D, Mosienko V, Kempermann G, Bader M, Alenina N (2013). Serotonin is required for exercise-induced adult hippocampal neurogenesis. J Neurosci, 33(19), 8270-8275. Abstract.  Author URL.

2012

Mosienko V, Bert B, Beis D, Matthes S, Fink H, Bader M, Alenina N (2012). Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Transl Psychiatry, 2 Abstract.  Author URL.

2011

Liskovykh M, Chuykin I, Ranjan A, Safina D, Popova E, Tolkunova E, Mosienko V, Minina JM, Zhdanova NS, Mullins JJ, et al (2011). Derivation, characterization, and stable transfection of induced pluripotent stem cells from Fischer344 rats. PLoS One, 6(11). Abstract.  Author URL.
Liskovykh MA, Chuĭkin IA, Ranjan A, Popova E, Tolkunova EN, Chechik LL, Malinin AI, Morozova AV, Mosienko V, Bader M, et al (2011). [Genetic manipulation and studying of differentiation properties of rat induced pluripotent stem cells]. Tsitologiia, 53(12), 946-951. Abstract.  Author URL.

2010

Chuykin I, Lapidus I, Popova E, Vilianovich L, Mosienko V, Alenina N, Binas B, Chai G, Bader M, Krivokharchenko A, et al (2010). Characterization of trophoblast and extraembryonic endoderm cell lineages derived from rat preimplantation embryos. PLoS One, 5(3). Abstract.  Author URL.
Matthes S, Mosienko V, Bashammakh S, Alenina N, Bader M (2010). Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology, 85(2), 95-109. Abstract.  Author URL.

2009

Alenina N, Kikic D, Todiras M, Mosienko V, Qadri F, Plehm R, Boyé P, Vilianovitch L, Sohr R, Tenner K, et al (2009). Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci U S A, 106(25), 10332-10337. Abstract.  Author URL.

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Teaching

Teaching responsibilities, 2020/21 

Neuroimmunology CSC4030 - Module co-lead, lecturer and tutor https://vle.exeter.ac.uk/course/view.php?id=9094

Frontiers in Neuroscience CSC4009 - Lecturer https://vle.exeter.ac.uk/course/view.php?id=9089

Neural Circuits CSC2018 - Lecturer https://vle.exeter.ac.uk/course/view.php?id=10156

Final Year Research Projects CSC4020 - Project Provider/Supervisor

Academic tutor to Y3 Neuroscience Students 

BMBS Medicine

Lecturer

PBL facilitator

 

Supervision / Group

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