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Dr Tim Harrower

Dr Tim Harrower

Consultant Neurologist, Clinical Lead for Physiology Speciality Lead for neurology Research in the South West NIHR

 01392 402457

 College House 

 

College House, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK

 Office hours:

 

                        

Overview

Dr Timothy Harrower gained his medical degree at the University of Cape Town having graduated gained an intercalated B.Sc. in Medical Biochemistry and Human Physiology (cum laude). During training on the medical rotation in Cambridge membership of the Royal of College of Physicians was acquired and specialist neurology training completed. Having being awarded a Welcome Trust Clinical Research Grant he undertook research into neural stem cell biology and the mechanisms of neural transplant rejection at the Cambridge Centre for Brain Repair (University of Cambridge) where he read for a PhD in neuroscience. In addition, he was involved in managing all the patients with Huntington's Disease who had received neural transplants on the NEST neural transplant program.

In 2007 he was appointed Consultant Neurologist at the Royal Devon and Exeter NHS Foundation Trust and as a visiting neurologist at North Devon District Hospital. He continues to run a very active clinical program of clinics in general neurology but this is complemented running the Multiple Sclerosis, Huntington’s Disease, Motor Neuron Disease and Botulinum Toxin service.

Teaching at all levels from patients, scholars, students, nurses, trainees and peers is embedded in daily activities and has been recognised by being awarded a teaching excellence award by the University of Exeter Medical where he holds a Senior Clinical Lectureship post and is the Clinical Lead for Physiology.

Outside interests include trying to keep up with his teenage sons on the tennis court, training to maintain a reasonable bowling average for the Hospital cricket team, and ensuring he gets arthritis by running all manner running race or challenge.

But the new found skill of gardening in Devon provides balm for his soul and distracts from the more challenging aspects of modern NHS clinical service provision. Ultimately he still holds the dream of having a sublime and silky smooth tennis backhand….


Secretary: 01392 402455

NHS Email: timothy.harrower@nhs.net

Also based at: Department of Neurology, Royal Devon and Exeter NHS Foundation Hospital, Barrack Road, Exeter, EX2 5DW


 

Qualifications

B.Sc. (Medical Science) (University of Witwatersrand)

B.Sc. Honours (Medical Biochemistry) (University of Cape Town)

MBCHB (University of Cape Town)

MRCP (Royal College of Physicians London)

P.hD (Cambridge University)

FRCP (Royal College of Physicians London)

Research

Research interests

As Chief Investigator and Principle Investigator an extensive and balanced portfolio of research with both academic and commercial clinical trials has been developed by Tim. Clinical Trials have included Phase 1 through to Phase 5 and post licensing trials.  Local, National and International Collaborations have allowed contributions to very large observational studies including Genome Wide Association Studies in Multiple Sclerosis and Comprehensive global longitudinal observational studies such as Enroll HD project. The main focus of current research is best described in the project list below.

Research projects

Current Projects:

 Developing therapies for Motor Neuron Disease

  • Developing Novel therapies for Huntington’s Disease
  • Developing therapies for Multiple Sclerosis (including and especially for Progressive subtypes of MS)
  • Developing Novel Botulinum Toxin Therapies
  • Developing Migraine therapies
  • Developing therapies for Tourette syndrome including Botulinum Toxin Therapies and Deep Brain stimulation
  • Developing therapeutic pathways for managing autoimmune encephalitis

​Grants

  • Wellcome Trust Senior Clinical Fellow

Research grants

  • 2000 Wellcome Trust
    Full research Grant for for completetion of PhD

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Edge R, Mills R, Tennant A, Diggle PJ, Young CA, Al-Chalabi A, Williams TL, Dick DJ, Talbot K, Burke G, et al (2020). Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? a national study reconciling previous conflicting literature. JOURNAL OF NEUROLOGY, 267(3), 607-615. Author URL.
Young CA, Mills R, Al-Chalabi A, Burke G, Chandran S, Dick DJ, Ealing J, Hanemann CO, Harrower T, Mcdermott CJ, et al (2020). Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF. Amyotroph Lateral Scler Frontotemporal Degener, 1-9. Abstract.  Author URL.
Hawton A, Green C, Goodwin E, Harrower T (2019). Health state utility values (QALY weights) for Huntington's disease: an analysis of data from the European Huntington's Disease Network (EHDN). Eur J Health Econ, 20(9), 1335-1347. Abstract.  Author URL.  Full text.
Lennox B, Yeeles K, Jones PB, Zandi M, Joyce E, Yu LM, Tomei G, Pollard R, Vincent SA, Shimazaki M, et al (2019). Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: Study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2). Trials, 20(1). Abstract.  Full text.
Young CA, Ealing J, McDermott C, Williams T, Al-Chalabi A, Majeed T, Burke G, Pinto A, Dick D, Talbot K, et al (2019). The relationships between symptoms, disability, perceived health and quality of life in amyotrophic lateral sclerosis/motor neuron disease. Amyotroph Lateral Scler Frontotemporal Degener, 20(5-6), 317-327. Abstract.  Author URL.
Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, Watts C, Tai Y, Pavese N, Savage JC, et al (2018). Outcome of cell suspension allografts in a patient with Huntington's disease. Ann Neurol, 84(6), 950-956. Abstract.  Author URL.  Full text.
Middleton RM, Rodgers WJ, Chataway J, Schmierer K, Rog D, Galea I, Akbari A, Tuite-Dalton K, Lockhart-Jones H, Griffiths D, et al (2018). Validating the portal population of the United Kingdom Multiple Sclerosis Register. Mult Scler Relat Disord, 24, 3-10. Abstract.  Author URL.
McGeachan AJ, Hobson EV, Al-Chalabi A, Stephenson J, Chandran S, Crawley F, Dick D, Donaghy C, Ellis CM, Gorrie G, et al (2017). A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener, 18(1-2), 1-9. Abstract.  Author URL.  Full text.
Muthukumar M, Desai K, Abogunrin S, Harrower T, Gabriel S, Dinet J (2017). Cost-effectiveness analysis of abobotulinumtoxinA for the treatment of cervical dystonia in the United Kingdom. Clinicoecon Outcomes Res, 9, 211-229. Abstract.  Author URL.
Abogunrin S, Brand S, Desai K, Dinet J, Gabriel S, Harrower T (2015). AbobotulinumtoxinA in the management of cervical dystonia in the United Kingdom: a budget impact analysis. Clinicoecon Outcomes Res, 7, 441-449. Abstract.  Author URL.
Greaves RF, Woollard GA, Hoad KE, Walmsley TA, Johnson LA, Briscoe S, Koetsier S, Harrower T, Gill JP (2014). Laboratory medicine best practice guideline: Vitamins A, E and the carotenoids in blood. Clinical Biochemist Reviews, 35(2), 81-113. Abstract.
Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, et al (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics, 45(11), 1353-1362. Abstract.
Hobson EV, McGeachan A, Al-Chalabi A, Chandran S, Crawley F, Dick D, Donaghy C, Ealing J, Ellis CM, Gorrie G, et al (2013). Management of sialorrhoea in motor neuron disease: a survey of current UK practice. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14(7-8), 521-527. Abstract.
Alkufri F, Harrower T, Rahman Y, Hughes E, Mundy H, Knibb JA, Moriarty J, Connor S, Samuel M (2013). Molybdenum cofactor deficiency presenting with a parkinsonism-dystonia syndrome. MOVEMENT DISORDERS, 28(3), 399-400. Author URL.
Barker RA, Mason SL, Harrower TP, Swain RA, Ho AK, Sahakian BJ, Mathur R, Elneil S, Thornton S, Hurrelbrink C, et al (2013). The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 84(6), 657-665. Author URL.
Orth M, Handley OJ, Schwenke C, Dunnett S, Wild EJ, Tabrizi SJ, Landwehrmeyer GB, Bachoud-Levi A-C, Bentivoglio AR, Biunno I, et al (2011). Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 82(12), 1409-+. Author URL.

Conferences

Shivane A, Edwards P, Hilton D, Cunningham R, Nabarro L, Harrower T (2017). A case of meningo-encephalitis with unusual neuropathology.  Author URL.
Dharia S, Harrower T (2015). CNS RELAPSE OF NHL MASQUERADING AS MILLER FISHER SYNDROME.  Author URL.
Lashley D, Gormley K, Harrower T (2012). Natal Natalizumab.  Author URL.

Publications by year


2020

Edge R, Mills R, Tennant A, Diggle PJ, Young CA, Al-Chalabi A, Williams TL, Dick DJ, Talbot K, Burke G, et al (2020). Do pain, anxiety and depression influence quality of life for people with amyotrophic lateral sclerosis/motor neuron disease? a national study reconciling previous conflicting literature. JOURNAL OF NEUROLOGY, 267(3), 607-615. Author URL.
Young CA, Mills R, Al-Chalabi A, Burke G, Chandran S, Dick DJ, Ealing J, Hanemann CO, Harrower T, Mcdermott CJ, et al (2020). Measuring quality of life in ALS/MND: validation of the WHOQOL-BREF. Amyotroph Lateral Scler Frontotemporal Degener, 1-9. Abstract.  Author URL.

2019

Hawton A, Green C, Goodwin E, Harrower T (2019). Health state utility values (QALY weights) for Huntington's disease: an analysis of data from the European Huntington's Disease Network (EHDN). Eur J Health Econ, 20(9), 1335-1347. Abstract.  Author URL.  Full text.
Lennox B, Yeeles K, Jones PB, Zandi M, Joyce E, Yu LM, Tomei G, Pollard R, Vincent SA, Shimazaki M, et al (2019). Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: Study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2). Trials, 20(1). Abstract.  Full text.
Young CA, Ealing J, McDermott C, Williams T, Al-Chalabi A, Majeed T, Burke G, Pinto A, Dick D, Talbot K, et al (2019). The relationships between symptoms, disability, perceived health and quality of life in amyotrophic lateral sclerosis/motor neuron disease. Amyotroph Lateral Scler Frontotemporal Degener, 20(5-6), 317-327. Abstract.  Author URL.

2018

Maxan A, Mason S, Saint-Pierre M, Smith E, Ho A, Harrower T, Watts C, Tai Y, Pavese N, Savage JC, et al (2018). Outcome of cell suspension allografts in a patient with Huntington's disease. Ann Neurol, 84(6), 950-956. Abstract.  Author URL.  Full text.
Middleton RM, Rodgers WJ, Chataway J, Schmierer K, Rog D, Galea I, Akbari A, Tuite-Dalton K, Lockhart-Jones H, Griffiths D, et al (2018). Validating the portal population of the United Kingdom Multiple Sclerosis Register. Mult Scler Relat Disord, 24, 3-10. Abstract.  Author URL.

2017

Shivane A, Edwards P, Hilton D, Cunningham R, Nabarro L, Harrower T (2017). A case of meningo-encephalitis with unusual neuropathology.  Author URL.
McGeachan AJ, Hobson EV, Al-Chalabi A, Stephenson J, Chandran S, Crawley F, Dick D, Donaghy C, Ellis CM, Gorrie G, et al (2017). A multicentre evaluation of oropharyngeal secretion management practices in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener, 18(1-2), 1-9. Abstract.  Author URL.  Full text.
Muthukumar M, Desai K, Abogunrin S, Harrower T, Gabriel S, Dinet J (2017). Cost-effectiveness analysis of abobotulinumtoxinA for the treatment of cervical dystonia in the United Kingdom. Clinicoecon Outcomes Res, 9, 211-229. Abstract.  Author URL.

2015

Abogunrin S, Brand S, Desai K, Dinet J, Gabriel S, Harrower T (2015). AbobotulinumtoxinA in the management of cervical dystonia in the United Kingdom: a budget impact analysis. Clinicoecon Outcomes Res, 7, 441-449. Abstract.  Author URL.
Dharia S, Harrower T (2015). CNS RELAPSE OF NHL MASQUERADING AS MILLER FISHER SYNDROME.  Author URL.

2014

Greaves RF, Woollard GA, Hoad KE, Walmsley TA, Johnson LA, Briscoe S, Koetsier S, Harrower T, Gill JP (2014). Laboratory medicine best practice guideline: Vitamins A, E and the carotenoids in blood. Clinical Biochemist Reviews, 35(2), 81-113. Abstract.

2013

Beecham AH, Patsopoulos NA, Xifara DK, Davis MF, Kemppinen A, Cotsapas C, Shah TS, Spencer C, Booth D, Goris A, et al (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics, 45(11), 1353-1362. Abstract.
Hobson EV, McGeachan A, Al-Chalabi A, Chandran S, Crawley F, Dick D, Donaghy C, Ealing J, Ellis CM, Gorrie G, et al (2013). Management of sialorrhoea in motor neuron disease: a survey of current UK practice. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14(7-8), 521-527. Abstract.
Alkufri F, Harrower T, Rahman Y, Hughes E, Mundy H, Knibb JA, Moriarty J, Connor S, Samuel M (2013). Molybdenum cofactor deficiency presenting with a parkinsonism-dystonia syndrome. MOVEMENT DISORDERS, 28(3), 399-400. Author URL.
Barker RA, Mason SL, Harrower TP, Swain RA, Ho AK, Sahakian BJ, Mathur R, Elneil S, Thornton S, Hurrelbrink C, et al (2013). The long-term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington's disease. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 84(6), 657-665. Author URL.

2012

Lashley D, Gormley K, Harrower T (2012). Natal Natalizumab.  Author URL.

2011

Orth M, Handley OJ, Schwenke C, Dunnett S, Wild EJ, Tabrizi SJ, Landwehrmeyer GB, Bachoud-Levi A-C, Bentivoglio AR, Biunno I, et al (2011). Observing Huntington's disease: the European Huntington's Disease Network's REGISTRY. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 82(12), 1409-+. Author URL.

Tim_Harrower Details from cache as at 2020-09-21 23:49:48

Refresh publications

External Engagement and Impact

Awards

  • QUDOS Highly Commended in the Physician Category (National)
  • Staff Aureus Teaching Award (UEMS)
  • Ciba-Geigy Gold Medal Best Medical Science Student (University of Witwatersrand (Wits))
  • Sackler Foundation Scholarship (Cambridge University)
  • D.R. Macintosh Foundation Scholarship (Wits and University of Cape Town (UCT))
  • Dr H.J. Van der Bijl Scholarship (Wits and UCT)
  • Convocation Merit Award (Wits)

Committee/panel activities

  • British Neurotoxin Network (Founding Director)
  • Clinical Research Speciality Lead for Neurology (Clinical Research Network South West Peninsula)
  • Clinical Research Sub-Speciality Lead for Motor Neuron disease (Clinical Research Network South West Peninsula)
  • President of the MND association in Devon

Editorial responsibilities

  • Invited to provide peer review for submitted Journal of Neurology, Practical Neurology, Brain and ACNR (Advances in Clinical Neurology and Rehabilitation)

Invited lectures

  • International Transplant Congress (Plenary Lecture) “Neural Transplantation”
  • Royal College of Physician Regional Lecture “Hyperkinetic Movement Disorders”

Media Coverage

  • Sky news and BBC news when trial results of Opera were published
  • BBC news when trial of Deep Brain Therapy was announced           
  • ECTRIMS Highlights package Program
  • Toxins Highlights package Program

Teaching

Undergraduate:

  • General Human Physiology for Medical Students (Years 1 and 2)
  • Clinical Neurology (Clinical Years)

 Post Graduate:

  • General Neurology for doctors in training including:
  • Foundation year Trainees
  • Core Medical Trainees
  • Specialist Registrars
  • Neurological principles for General Practioners across the region
  • Neurological perspectives for other specialities including:
    • Ophthalmology
    • Psychiatry
    • Orthopaedic surgeons
    • Elderly Care Physicians
  • Training Programs for Spasticity Management
    • eg Continuum of Learning to Improve Management with Botulinum Toxin Project (CLIMB) in spasticity
  • Training Programs for Dystonia
    • eg CLIMB project for Cervical Dystonia

 

Teaching sessions academic year 2019/2020
Session Title Activity dates Venue
     
Intracranial pressure and cerebral blood flow 06/12/2019 NC12
Physiological changes in pregnancy 08/01/2020 NC12
The placenta 10/01/2020 NC12
Respiratory Physiology 2: gas transport/haemoglobin 21/02/2020 NC12
Electricity and the heart 13/03/2020 NC12
Assesssing Cardiac Function 18/03/2020 NC12
Atheroma formation - cell,molecular and histology of this and calcification 18/03/2020 NC12
Brain Lesions and control of behaviour  24/04/2020 NC12
Dementia  24/04/2020 NC12
The kidney as producer, excreter and regulator 04/05/2020 NC12
Control, composition and volume of ECF 04/05/2020 NC12
Diuretics  13/05/2020 NC12
Gastroeneterology Lecture 27/05/2020 NC12
Liver and Pancreas 03/06/2020 NC12
     
LSRC year 1  (Tuesdays)    
Temperature regulation 05/11/2019 LSRC
Motor Pathways 10/12/2019 LSRC
Autonomic Nervous System 17/12/2019 LSRC
Birth and the First Breath 14/01/2020 LSRC
Thyroid Function and Dysfunction 21/01/2020 LSRC
Cardiac Cycle 10/03/2020 LSRC
Anaemia 17/03/2020 LSRC
Interpretation of ABG2 12/05/2020 LSRC
The Stomach, Acid vomiting etc 26/05/2020 LSRC
Liver Function Tests  02/06/2020 LSRC
Biliary Tree Disease  09/06/2020 LSRC
     
Year 2    
Movement Dysorders 23/10/2019 NC12
Living with a Movement Disorder 01/11/2019 NC12
Multiple Sclerosis 25/10/2019 NC12
Epilepsy  30/10/2019 NC12
Causes, Prevention & Consequences of DVT/VTE 18/12/2019 NC12
Haemoglobinopathies 18/12/2019 NC12
Brain Lesions 24/04/2020  
     
LRSC Year 2 (Thursdays)    
     
Oedema, features, aetiology & treatment 19/03/2020 LSRC
     
Are they dead and what killed them 02/04/2020 LSRC
     
Brain Phantoms 23/04/2020 LSRC
     
Smell and Taste  14/05/2020 LSRC
     
Year 4 and 5    
Neurological Emergencies (4 session per year)   RILD
Pattern Recognition in Neurology (4 sessions per year)   RILD
Headache CPC (4 sessions per year    RILD
     
     
ARENA sessions    
MND session  16/03/2020 TBC
Huntington's Disease session 24/03/2020 TBC
     
Other Teaching     
     
MS One disease? Regional MS Academy  18/06/2019 Jurys Inn
Managing Movement Disorders Dept of Medicine Lunchtime)   RILD
What's new in Neurology 05/11/2019 RILD
Weakness not due to stroke   RILD
Psychiatric Neuroinflammation (Liason Psychiatry Course) 13/06/2019 Mecure Hotel
Management of Sialhorrhea 21/09/2020 Exeter Race Course
Tremor and Siallhorrhea Management (British Geriatric Meeting) 03/10/2019 Mercure Hotel
Hyperkinetic Movement Disorders  (GIM Traing  Day ) 18/11/2019 RILD
Brain  Stem Bother (Dept Medicine Lunchtime)  19/11/2019 RILD 
MND Symposia (MND Diagnosis and Management) 20/11/2019  
Other cuases of Back Pain 22/11/2019 Sandy Park
PACES course  (all day Saturday) 25/01/2020  
ABC of  modern epilepsy management 04/02/2020 Nuffield
MND Spire session (10:00 - 2 hours) 16/03/2020 G18
Immunomudulation in MS: Implications for Multiple Sclerosis 26/03/2020 Bristol
SINAPPS 2 (Psychiatry MAC - Edgemoor hotel, Bovey tracey, haytor road, Newton Abbot TQ13 9LE 20/04/2020 Okehampton
     
Other teaching Commitments    
Angof session  11/12/2019  
Inspire  Clinical Research Lecture  05/11/2019  
     
   
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     
     

 

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