COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Talitha Kerrigan

Lecturer

 01392 72 7080

 Medical School Building G.01

 

Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK

Overview

Broad research specialisms

  • Models of Dementia
  • Neuroinflammation and glial biology
  • Induced pluripotent stem cells (iPSCs)
  • In vitro electrophysiology
  • Synaptic and intrinsic neuroplasticity

Professional Memberships

Physiological Society

British Neuroscience Association

British Society for Neuroendocrinology

Society for Neuroscience

 

Qualifications

  • 2004 BSc (Hons) Anatomical Science, University of Bristol
  • 2008 PhD Neurophysiology, University of Leeds
  • 2015 PCAP, University of Exeter
  • 2016 Fellow of the Higher Education Academy

 

Research

Research projects

Current Projects:

  • Functional characterisation of iPSC- derived neural cells from individuals with high genetic loading for AD. (Alzheimer’s Society PhD studentship in collaboration with Prof. Katie Lunnon, Exeter).
  • The dynamic role of astrocyte secreted APOE4 in Alzheimer’s disease; investigating using human induced pluripotent stem cells (Alzheimer’s Society Grant, in collaboration with Prof Andy Randall, Exeter and Prof Seth Love, Bristol)

Grants/Funding:

2019    Alzheimer’s Research UK Oxford Network Pilot Grant        

            Role: Co-Investigator (PI – Dr L.Thei University of Reading)

            Title: TRPM8 Ion Channel Distribution in Aged J20 Microglia

2018    Alzheimer’s Research UK South West Network Centre Equipment Grant  

            Role: Co-Investigator (PI – Jennifer Imm, Exeter)

            Title: Lonza Cytosmart 2

2017    Alzheimer’s Research UK Network Cooperation Grant

Role: PI (PI – Dr Mark Dallas, Reading)

Title: Microglial remodelling in dementia

2017    Alzheimer's Society Undergraduate Summer Studentship

            Role: Co-Investigator (PI – Dr Craig Beall, Exeter)

Title: Measurement of cellular metabolism in IPSC-derived astrocytes with high genetic load for Alzheimer's disease - impact of glucose variation

2016    BRACE Pilot Grant

Role: PI

Title: Amyloid-beta clearance and neuronal function in a human model of Alzheimer’s disease.

2016    Alzheimer’s Research UK South West Network Centre Pilot Grant

Role: Co-Investigator (PI – Jennifer Imm)

Title: Characterisation of iPSC-derived microglial cells with high and low genetic loading for Alzheimer’s disease.

2016    Alzheimer’s Research UK Equipment Grant

Role: Co-Investigator (PI - Prof Andrew Randall)

Title: Contribution to the purchase of a Ti-Sapphire laser to enable establishment of multiphoton fluorescence imaging facility.

2015    Alzheimer’s Research UK Network Centre Pilot Grant                                                         Role: PI

Title: Epigenetic regulation of amyloid beta clearance and neuronal function in a human model of Alzheimer’s disease.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Imm J, Kerrigan TL, Jeffries A, Lunnon K (In Press). Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease. Epigenomics, 9(11), 1455-1468. Abstract.  Author URL.  Full text.
Thei L, Imm J, Kaisis E, Dallas ML, Kerrigan TL (2018). Microglia in Alzheimer's Disease: a Role for Ion Channels. Front Neurosci, 12 Abstract.  Author URL.
Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text.
Kerrigan TL, Brown JT, Randall AD (2014). Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse. Neuropharmacology, 79, 515-524. Abstract.  Author URL.
Kerrigan TL, Randall AD (2013). A new player in the "synaptopathy" of Alzheimer's disease - arc/arg 3.1. Front Neurol, 4 Abstract.  Author URL.
Whitehead G, Jo J, Hogg EL, Piers T, Kim D-H, Seaton G, Seok H, Bru-Mercier G, Son GH, Regan P, et al (2013). Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus. Brain, 136(Pt 12), 3753-3765. Abstract.  Author URL.
Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL, Barbuti PA, Jo J, Tyler SJ, Allen SJ, et al (2013). Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling. Stem Cell Res, 11(3), 1206-1221. Abstract.  Author URL.
Watt NT, Taylor DR, Kerrigan TL, Griffiths HH, Rushworth JV, Whitehouse IJ, Hooper NM (2012). Prion protein facilitates uptake of zinc into neuronal cells. Nat Commun, 3 Abstract.  Author URL.
Kerrigan TL, Daniel J W, Regan PL, Cho K (2012). The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction. Front Mol Neurosci, 5 Abstract.  Author URL.
Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo S-C, Bru-Mercier G, Dickinson B, Scullion S, Sheng M, Collingridge G, et al (2011). Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β. Nat Neurosci, 14(5), 545-547. Abstract.  Author URL.
Dallas ML, Boyle JP, Milligan CJ, Sayer R, Kerrigan TL, McKinstry C, Lu P, Mankouri J, Harris M, Scragg JL, et al (2011). Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1. FASEB J, 25(5), 1519-1530. Abstract.  Author URL.
Kerrigan TL, Atkinson L, Peers C, Pearson HA (2008). Modulation of 'A'-type K+ current by rodent and human forms of amyloid beta protein. Neuroreport, 19(8), 839-843. Abstract.  Author URL.

Publications by year


In Press

Imm J, Kerrigan TL, Jeffries A, Lunnon K (In Press). Using induced pluripotent stem cells to explore genetic and epigenetic variation associated with Alzheimer's disease. Epigenomics, 9(11), 1455-1468. Abstract.  Author URL.  Full text.

2018

Thei L, Imm J, Kaisis E, Dallas ML, Kerrigan TL (2018). Microglia in Alzheimer's Disease: a Role for Ion Channels. Front Neurosci, 12 Abstract.  Author URL.

2015

Tamagnini F, Novelia J, Kerrigan TL, Brown JT, Tsaneva-Atanasova KT, Randall AD (2015). Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice. Front. Cell. Neurosci., 9 Full text.

2014

Kerrigan TL, Brown JT, Randall AD (2014). Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse. Neuropharmacology, 79, 515-524. Abstract.  Author URL.

2013

Kerrigan TL, Randall AD (2013). A new player in the "synaptopathy" of Alzheimer's disease - arc/arg 3.1. Front Neurol, 4 Abstract.  Author URL.
Whitehead G, Jo J, Hogg EL, Piers T, Kim D-H, Seaton G, Seok H, Bru-Mercier G, Son GH, Regan P, et al (2013). Acute stress causes rapid synaptic insertion of Ca2+ -permeable AMPA receptors to facilitate long-term potentiation in the hippocampus. Brain, 136(Pt 12), 3753-3765. Abstract.  Author URL.
Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL, Barbuti PA, Jo J, Tyler SJ, Allen SJ, et al (2013). Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling. Stem Cell Res, 11(3), 1206-1221. Abstract.  Author URL.

2012

Watt NT, Taylor DR, Kerrigan TL, Griffiths HH, Rushworth JV, Whitehouse IJ, Hooper NM (2012). Prion protein facilitates uptake of zinc into neuronal cells. Nat Commun, 3 Abstract.  Author URL.
Kerrigan TL, Daniel J W, Regan PL, Cho K (2012). The role of neuronal calcium sensors in balancing synaptic plasticity and synaptic dysfunction. Front Mol Neurosci, 5 Abstract.  Author URL.

2011

Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo S-C, Bru-Mercier G, Dickinson B, Scullion S, Sheng M, Collingridge G, et al (2011). Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β. Nat Neurosci, 14(5), 545-547. Abstract.  Author URL.
Dallas ML, Boyle JP, Milligan CJ, Sayer R, Kerrigan TL, McKinstry C, Lu P, Mankouri J, Harris M, Scragg JL, et al (2011). Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1. FASEB J, 25(5), 1519-1530. Abstract.  Author URL.

2008

Kerrigan TL, Atkinson L, Peers C, Pearson HA (2008). Modulation of 'A'-type K+ current by rodent and human forms of amyloid beta protein. Neuroreport, 19(8), 839-843. Abstract.  Author URL.

Talitha_Kerrigan Details from cache as at 2019-01-22 03:53:31

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External Engagment and Impact

Awards

  • 2018 – Above and Beyond Award for Collaboration
  • 2016 – Aspire Fellow

Committee/panel activities

  • Physiological Society Neuroscience Theme Lead
  • Alzheimer’s Research UK Early-career representative

Editorial responsibilities

  • Associate Editor - Journal of Embryology and Stem Cell Research

Invited lectures

June 2018:                  Alzheimer’s Research UK Southwest Network Open public day

Sept 2017:                   Exeter Dementia Day, Rougemont Hotel, Exeter

August 2017:               7th International Conference on Dementia, Toronto

July 2016:                   Alzheimer’s Research UK Southwest Network meeting

June 2016:                  BRACE and Exeter Dementia Action Alliance Workshop

May 2016:                   Pint of Science Festival Exeter

September 2015:        GW4 Early career Neuroscience Day, Bristol

Supervision / Group

Postgraduate researchers

  • Jennifer Imm PhD student (Alzheimer’s Society, co-supervisor)

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