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Dr Suzy Hope

Dr Suzy Hope

Honorary Clinical Lecturer

I am a geriatrician with clinical and academic interests in diabetes in older people (in particular hypoglycaemia), and in community geriatrics and dementia. I have been fortunate in working in Professor Andrew Hattersley’s clinical diabetes team for several years, recently completing a PhD on Hypoglycaemia in Older People with Diabetes. I have always been keen to pursue research that is meaningful for patients and that has a close clinical impact, and will be striving to continue this in my ongoing research both in diabetes and in community geriatrics. 

Qualifications

  • 2016 PhD (University of Exeter)
  • 2011 MSc Diabetes (Queen Margaret University, Edinburgh)
  • 2009 MRCP (Royal College of Physicians, London)
  • 2004 MB ChB (University of Bristol)
  • 2001 BSc Neuroscience (University of Bristol)

Research

Research interests

Diabetes in older people: I used the new method developed by the NIHR Exeter team (urine C-peptide creatinine ratio), to demonstrate that patients who meet clinical criteria for Type 2 diabetes can have significant insulin deficiency – in the range normally expected in Type 1 diabetes – yet in terms of clinical characteristics are not distinguishable from those patients with Type 2 diabetes but preserved endogenous insulin production. We have since shown that a simple blood test – random non-fasting C-peptide – is well-correlated with the gold-standard measure of endogenous insulin production, C-peptide in a mixed meal tolerance test. Using this simple blood test, we have shown both by continuous glucose monitoring studies and by questionnaires that these patients with clinically-diagnosed Type 2 diabetes but severe insulin deficiency are at much higher risk of hypoglycaemia than clinically-similar seeming patients with Type 2 diabetes but preserved insulin production. Recognition of hypoglycaemia in elderly patients can be difficult, due to the non-specific nature of symptoms which are not dissimilar from many other clinical conditions in this age group. Random non-fasting C-peptide may thus represent a useful additional clinical tool in recognizing patients at high risk of hypoglycaemia. 

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Hope SV, Taylor PJ, Shields BM, Hattersley AT, Hamilton W (In Press). Are we missing hypoglycaemia?. Elderly patients with insulin-treated diabetes present to. primary care frequently with non-specific symptoms. associated with hypoglycaemia. Primary Care Diabetes Full text.
Hope SV, Knight BA, Shields BM, Hill AV, Choudhary P, Strain WD, McDonald TJ, Jones AG (In Press). Random non-fasting C-peptide testing can identify patients with insulin-treated type 2 diabetes at high risk of hypoglycaemia. Diabetologia
Gadsby R, Hope SV, Hambling C, Carnegie A (2017). Frailty, older people and type 2 diabetes. Diabetes and Primary Care, 19, 18-22.
Hope SV, Wienand-Barnett S, Shepherd M, King SM, Fox C, Khunti K, Oram RA, Knight BA, Hattersley AT, Jones AG, et al (2016). Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis. British Journal of General Practice, 66(646), e315-e322. Abstract.  Full text.
Hope SV, Knight BA, Shields BM, Hattersley AT, McDonald TJ, Jones AG (2016). Random non-fasting C-peptide: bringing robust assessment of endogenous insulin secretion to the clinic. Diabet Med, 33(11), 1554-1558. Abstract.  Author URL.  Full text.
Hope SV, Strain WD (2013). Hypoglycemia in the elderly. Diabetic Hypoglycemia, 6(1), 3-10. Abstract.
Hope SV, Jones AG, Goodchild E, Shepherd M, Besser REJ, Shields B, McDonald T, Knight BA, Hattersley A (2013). Urinary C-peptide creatinine ratio detects absolute insulin deficiency in Type 2 diabetes. Diabet Med, 30(11), 1342-1348. Abstract.  Author URL.  Full text.
Jones AG, Besser REJ, Shields BM, McDonald TJ, Hope SV, Knight BA, Hattersley AT (2012). Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin. BMC Endocrine Disorders, 12 Abstract.  Full text.
Geneste J, Pereira B, Arnaud B, Christol N, Liotier J, Blanc O, Teissedre F, Hope S, Schwan R, Llorca PM, et al (2012). CAGE, RAPS4, RAPS4-QF and AUDIT screening tests for men and women admitted for acute alcohol intoxication to an emergency department: Are standard thresholds appropriate?. Alcohol and Alcoholism, 47(3), 273-281. Abstract.
Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman P, Oram RA, Knight BA, Hattersley AT (2011). Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. Diabet Med, 28(9), 1034-1038. Abstract.  Author URL.

Conferences

Bhaskaran B, Saulat A, Hope SV (2017). A rare case of concurrent spinal and posterior circulation stroke. 3rd European Stroke Organisation Conference (ESOC 2017). 16th - 18th May 2017. Abstract.
Hope SV, Knight BA, Shields BM, Hill AV, Choudhary P, Strain WD, Hattersley AT, McDonald TJ, Jones AG (2017). Random non-fasting C-peptide can be used as a risk assessment tool for hypoglycaemia in elderly insulin-treated patients with type 2 diabetes. British Geriatrics Society. 23rd - 25th Nov 2016. Author URL.
Hope SV, Knight BA, Shields BM, Strain WD, Hattersley AT, Choudhary P, Jones AG (2016). Low c-peptide is associated with high glycaemic variability and hypoglycaemia in insulin-treated patients with Type 2 diabetes. Diabetes UK Professional Conference 2016. 2nd - 4th Mar 2016. Author URL.
Hope SV, Knight BA, Shields BM, Strain WD, Hattersley AT, Choudhary P, Jones AG (2016). Random non-fasting C-peptide can be used as a risk assessment tool for hypoglycaemia in insulin-treated patients with type 2 diabetes. 12th Congress of the European Union Geriatric Medicine Society. 5th - 7th Oct 2016.
Hope SV, Knight BA, Shields BM, Hattersley AT, McDonald TJ, Jones AG (2016). Random non-fasting c-peptide provides an accurate measure of endogenous insulin secretion for clinical practice. Diabetes UK Professional Conference 2016. 2nd - 4th Mar 2016. Author URL.
Hope SV, McDonald TJ, Hill AV, Strain WD, Hattersley AT (2015). Low c-peptide is associated in insulin-treated patients with hypoglycaemia unawareness as well as hypoglycaemia frequency. Diabetes UK Professional Conference 2015. 11th - 13th Mar 2015. Author URL.
Hope SV, Taylor PJ, Shields BM, Oram RA, Chakera A, Hattersley AT (2014). Are we missing hypoglycaemia in elderly people?. 10th Congress of the European Union Geriatric Medicine Society. 17th - 19th Sep 2014.
Hope SV, Taylor PJ, Shields BM, Oram RA, Chakera AJ, Strain WD, Hattersley AT (2014). Non-specific symptoms associated with hypoglycaemia in the elderly are common in patients treated with metformin only, as well as those treated with insulin or sulphonylureas. Diabetes UK Professional Conference 2014. 5th - 7th Mar 2014. Author URL.
Hope SV, Sword JE (2014). Referrals for Independent Medical Capacity Advocates: exploratory survey for appropriate audit data collection method. British Geriatrics Society. 20th - 22nd Nov 2013. Abstract.
Stevens D, Campbell C, Hope SV, Morris A (2013). Improving end of life care on dementia inpatient wards. British Geriatrics Society. 28th - 30th Nov 2012. Abstract.  Author URL.
Hope SV, Jones AG, Shepherd M, Shields BM, Strain WD, McDonald T, Knight BA, Hattersley AT (2013). Urinary C-peptide creatinine ratio to detect absolute insulin deficiency in type 2 diabetes. Spring Meeting for Clinician Scientists in Training. 27th - 27th Feb 2013. Author URL.
Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman PA, Oram RA, Knight BA, Hattersley AT (2011). Measuring endogenous insulin secretion: does it matter in insulin treated patients?. Diabetes UK Annual Professional Conference 2011. 30th Mar - 1st Apr 2011.
Jones AG, Besser REJ, Shields BM, McDonald TJ, Hope SV, Oram RA, Knight BA, Hattersley AT (2011). Practical alternatives to the mixed meal tolerance test in insulin treated diabetes. Diabetes UK Annual Professional Conference 2011. 30th Mar - 1st Apr 2011.
Hope SV, Jones AG, Goodchild E, Shepherd M, Besser REJ, Shields BM, McDonald TJ, Knight BA, Hattersley AT (2011). Urinary C-Peptide Creatinine Ratio (UCPCR) can be used as a screening tool to detect absolute insulin deficiency in type 2 diabetes. Diabetes UK Annual Professional Conference 2011. 30th Mar - 1st Apr 2011.
Hope SV, Jones AG, Goodchild E, Shepherd M, Besser REJ, Shields BM, McDonald TJ, Knight BA, Hattersley AT (2011). Urinary C-Peptide Creatinine Ratio (UCPCR) can be used as a screening tool to detect absolute insulin deficiency in type 2 diabetes. British Geriatrics Society. 6th - 8th Apr 2011. Author URL.
Jones AG, Hope SV, Shepherd M, Shields BM, Besser REJ, Wensley KJ, Githens-Mazer G, McDonald TJ, Knight BA, Hattersley AT, et al (2010). Do patients with Long-Standing Type 2 Diabetes Develop Absolute Insulin Deficiency?. American Diabetes Association 70th Scientific Sessions (2010). 25th - 29th Jun 2010. Author URL.
Hope SV, Shepherd M, Shields BM, McDonald T, Knight BA, Hattersley AT (2010). Patients with long-standing type 2 diabetes can develop absolute insulin deficiency. European Association for the Study of Diabetes. 20th - 24th Sep 2010. Author URL.

Publications by year


In Press

Hope SV, Taylor PJ, Shields BM, Hattersley AT, Hamilton W (In Press). Are we missing hypoglycaemia?. Elderly patients with insulin-treated diabetes present to. primary care frequently with non-specific symptoms. associated with hypoglycaemia. Primary Care Diabetes Full text.
Hope SV, Knight BA, Shields BM, Hill AV, Choudhary P, Strain WD, McDonald TJ, Jones AG (In Press). Random non-fasting C-peptide testing can identify patients with insulin-treated type 2 diabetes at high risk of hypoglycaemia. Diabetologia

2017

Bhaskaran B, Saulat A, Hope SV (2017). A rare case of concurrent spinal and posterior circulation stroke. 3rd European Stroke Organisation Conference (ESOC 2017). 16th - 18th May 2017. Abstract.
Gadsby R, Hope SV, Hambling C, Carnegie A (2017). Frailty, older people and type 2 diabetes. Diabetes and Primary Care, 19, 18-22.
Hope SV, Knight BA, Shields BM, Hill AV, Choudhary P, Strain WD, Hattersley AT, McDonald TJ, Jones AG (2017). Random non-fasting C-peptide can be used as a risk assessment tool for hypoglycaemia in elderly insulin-treated patients with type 2 diabetes. British Geriatrics Society. 23rd - 25th Nov 2016. Author URL.

2016

Hope SV, Knight BA, Shields BM, Strain WD, Hattersley AT, Choudhary P, Jones AG (2016). Low c-peptide is associated with high glycaemic variability and hypoglycaemia in insulin-treated patients with Type 2 diabetes. Diabetes UK Professional Conference 2016. 2nd - 4th Mar 2016. Author URL.
Hope SV, Wienand-Barnett S, Shepherd M, King SM, Fox C, Khunti K, Oram RA, Knight BA, Hattersley AT, Jones AG, et al (2016). Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis. British Journal of General Practice, 66(646), e315-e322. Abstract.  Full text.
Hope SV, Knight BA, Shields BM, Strain WD, Hattersley AT, Choudhary P, Jones AG (2016). Random non-fasting C-peptide can be used as a risk assessment tool for hypoglycaemia in insulin-treated patients with type 2 diabetes. 12th Congress of the European Union Geriatric Medicine Society. 5th - 7th Oct 2016.
Hope SV, Knight BA, Shields BM, Hattersley AT, McDonald TJ, Jones AG (2016). Random non-fasting C-peptide: bringing robust assessment of endogenous insulin secretion to the clinic. Diabet Med, 33(11), 1554-1558. Abstract.  Author URL.  Full text.
Hope SV, Knight BA, Shields BM, Hattersley AT, McDonald TJ, Jones AG (2016). Random non-fasting c-peptide provides an accurate measure of endogenous insulin secretion for clinical practice. Diabetes UK Professional Conference 2016. 2nd - 4th Mar 2016. Author URL.

2015

Hope SV, McDonald TJ, Hill AV, Strain WD, Hattersley AT (2015). Low c-peptide is associated in insulin-treated patients with hypoglycaemia unawareness as well as hypoglycaemia frequency. Diabetes UK Professional Conference 2015. 11th - 13th Mar 2015. Author URL.

2014

Hope SV, Taylor PJ, Shields BM, Oram RA, Chakera A, Hattersley AT (2014). Are we missing hypoglycaemia in elderly people?. 10th Congress of the European Union Geriatric Medicine Society. 17th - 19th Sep 2014.
Hope SV, Taylor PJ, Shields BM, Oram RA, Chakera AJ, Strain WD, Hattersley AT (2014). Non-specific symptoms associated with hypoglycaemia in the elderly are common in patients treated with metformin only, as well as those treated with insulin or sulphonylureas. Diabetes UK Professional Conference 2014. 5th - 7th Mar 2014. Author URL.
Hope SV, Sword JE (2014). Referrals for Independent Medical Capacity Advocates: exploratory survey for appropriate audit data collection method. British Geriatrics Society. 20th - 22nd Nov 2013. Abstract.

2013

Hope SV, Strain WD (2013). Hypoglycemia in the elderly. Diabetic Hypoglycemia, 6(1), 3-10. Abstract.
Stevens D, Campbell C, Hope SV, Morris A (2013). Improving end of life care on dementia inpatient wards. British Geriatrics Society. 28th - 30th Nov 2012. Abstract.  Author URL.
Hope SV, Jones AG, Goodchild E, Shepherd M, Besser REJ, Shields B, McDonald T, Knight BA, Hattersley A (2013). Urinary C-peptide creatinine ratio detects absolute insulin deficiency in Type 2 diabetes. Diabet Med, 30(11), 1342-1348. Abstract.  Author URL.  Full text.
Hope SV, Jones AG, Shepherd M, Shields BM, Strain WD, McDonald T, Knight BA, Hattersley AT (2013). Urinary C-peptide creatinine ratio to detect absolute insulin deficiency in type 2 diabetes. Spring Meeting for Clinician Scientists in Training. 27th - 27th Feb 2013. Author URL.

2012

Jones AG, Besser REJ, Shields BM, McDonald TJ, Hope SV, Knight BA, Hattersley AT (2012). Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin. BMC Endocrine Disorders, 12 Abstract.  Full text.
Geneste J, Pereira B, Arnaud B, Christol N, Liotier J, Blanc O, Teissedre F, Hope S, Schwan R, Llorca PM, et al (2012). CAGE, RAPS4, RAPS4-QF and AUDIT screening tests for men and women admitted for acute alcohol intoxication to an emergency department: Are standard thresholds appropriate?. Alcohol and Alcoholism, 47(3), 273-281. Abstract.

2011

Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman PA, Oram RA, Knight BA, Hattersley AT (2011). Measuring endogenous insulin secretion: does it matter in insulin treated patients?. Diabetes UK Annual Professional Conference 2011. 30th Mar - 1st Apr 2011.
Jones AG, Besser REJ, Shields BM, McDonald TJ, Hope SV, Oram RA, Knight BA, Hattersley AT (2011). Practical alternatives to the mixed meal tolerance test in insulin treated diabetes. Diabetes UK Annual Professional Conference 2011. 30th Mar - 1st Apr 2011.
Hope SV, Jones AG, Goodchild E, Shepherd M, Besser REJ, Shields BM, McDonald TJ, Knight BA, Hattersley AT (2011). Urinary C-Peptide Creatinine Ratio (UCPCR) can be used as a screening tool to detect absolute insulin deficiency in type 2 diabetes. Diabetes UK Annual Professional Conference 2011. 30th Mar - 1st Apr 2011.
Hope SV, Jones AG, Goodchild E, Shepherd M, Besser REJ, Shields BM, McDonald TJ, Knight BA, Hattersley AT (2011). Urinary C-Peptide Creatinine Ratio (UCPCR) can be used as a screening tool to detect absolute insulin deficiency in type 2 diabetes. British Geriatrics Society. 6th - 8th Apr 2011. Author URL.
Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman P, Oram RA, Knight BA, Hattersley AT (2011). Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. Diabet Med, 28(9), 1034-1038. Abstract.  Author URL.

2010

Jones AG, Hope SV, Shepherd M, Shields BM, Besser REJ, Wensley KJ, Githens-Mazer G, McDonald TJ, Knight BA, Hattersley AT, et al (2010). Do patients with Long-Standing Type 2 Diabetes Develop Absolute Insulin Deficiency?. American Diabetes Association 70th Scientific Sessions (2010). 25th - 29th Jun 2010. Author URL.
Hope SV, Shepherd M, Shields BM, McDonald T, Knight BA, Hattersley AT (2010). Patients with long-standing type 2 diabetes can develop absolute insulin deficiency. European Association for the Study of Diabetes. 20th - 24th Sep 2010. Author URL.

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