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Dr Suzy Hope

Dr Suzy Hope

Honorary Clinical Lecturer

I am a geriatrician with clinical and academic interests in diabetes in older people (in particular hypoglycaemia), and in community geriatrics and dementia. I have been fortunate in working in Professor Andrew Hattersley’s clinical diabetes team for several years, recently completing a PhD on Hypoglycaemia in Older People with Diabetes. I have always been keen to pursue research that is meaningful for patients and that has a close clinical impact, and will be striving to continue this in my ongoing research both in diabetes and in community geriatrics. 

Qualifications

  • 2016 PhD (University of Exeter)
  • 2011 MSc Diabetes (Queen Margaret University, Edinburgh)
  • 2009 MRCP (Royal College of Physicians, London)
  • 2004 MB ChB (University of Bristol)
  • 2001 BSc Neuroscience (University of Bristol)

Research

Research interests

Diabetes in older people: I used the new method developed by the NIHR Exeter team (urine C-peptide creatinine ratio), to demonstrate that patients who meet clinical criteria for Type 2 diabetes can have significant insulin deficiency – in the range normally expected in Type 1 diabetes – yet in terms of clinical characteristics are not distinguishable from those patients with Type 2 diabetes but preserved endogenous insulin production. We have since shown that a simple blood test – random non-fasting C-peptide – is well-correlated with the gold-standard measure of endogenous insulin production, C-peptide in a mixed meal tolerance test. Using this simple blood test, we have shown both by continuous glucose monitoring studies and by questionnaires that these patients with clinically-diagnosed Type 2 diabetes but severe insulin deficiency are at much higher risk of hypoglycaemia than clinically-similar seeming patients with Type 2 diabetes but preserved insulin production. Recognition of hypoglycaemia in elderly patients can be difficult, due to the non-specific nature of symptoms which are not dissimilar from many other clinical conditions in this age group. Random non-fasting C-peptide may thus represent a useful additional clinical tool in recognizing patients at high risk of hypoglycaemia. 

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Hope SV, Jones AG, Goodchild E, Shepherd M, Besser REJ, Shields B, McDonald T, Knight BA, Hattersley A (2013). Urinary C-peptide creatinine ratio detects absolute insulin deficiency in Type 2 diabetes. Diabet Med, 30(11), 1342-1348. Abstract.  Author URL.  Full text.
Jones AG, Besser REJ, Shields BM, McDonald TJ, Hope SV, Knight BA, Hattersley AT (2012). Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin. BMC Endocrine Disorders, 12 Abstract.
Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman P, Oram RA, Knight BA, Hattersley AT (2011). Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. Diabet Med, 28(9), 1034-1038. Abstract.  Author URL.

Conferences

Hope SV, Jones A, Goodchild E, Shepherd M, Besser REJ, Shields B, McDonald T, Knight BA, Hattersley A (2011). URINARY C-PEPTIDE CREATININE RATIO (UCPCR) CAN BE USED AS a SCREENING TOOL TO DETECT ABSOLUTE INSULIN DEFICIENCY IN PEOPLE WITH TYPE 2 DIABETES.  Author URL.
Hope SV, Shepherd M, Shields BM, McDonald T, Knight BA, Hattersley AT (2010). Patients with long-standing type 2 diabetes can develop absolute insulin deficiency.  Author URL.

Publications by year


2013

Hope SV, Jones AG, Goodchild E, Shepherd M, Besser REJ, Shields B, McDonald T, Knight BA, Hattersley A (2013). Urinary C-peptide creatinine ratio detects absolute insulin deficiency in Type 2 diabetes. Diabet Med, 30(11), 1342-1348. Abstract.  Author URL.  Full text.

2012

Jones AG, Besser REJ, Shields BM, McDonald TJ, Hope SV, Knight BA, Hattersley AT (2012). Assessment of endogenous insulin secretion in insulin treated diabetes predicts postprandial glucose and treatment response to prandial insulin. BMC Endocrine Disorders, 12 Abstract.

2011

Hope SV, Jones A, Goodchild E, Shepherd M, Besser REJ, Shields B, McDonald T, Knight BA, Hattersley A (2011). URINARY C-PEPTIDE CREATININE RATIO (UCPCR) CAN BE USED AS a SCREENING TOOL TO DETECT ABSOLUTE INSULIN DEFICIENCY IN PEOPLE WITH TYPE 2 DIABETES.  Author URL.
Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman P, Oram RA, Knight BA, Hattersley AT (2011). Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. Diabet Med, 28(9), 1034-1038. Abstract.  Author URL.

2010

Hope SV, Shepherd M, Shields BM, McDonald T, Knight BA, Hattersley AT (2010). Patients with long-standing type 2 diabetes can develop absolute insulin deficiency.  Author URL.

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