Seema Chandramohan Namboori
Research Technician (LSI)
Living Systems Institute
Living Systems Institute, University of Exeter, Stocker Road, Exeter, EX4 4QD
Research involves disease modeling of neurodegenerative diseases, including motor neuron disease, by differentiating patient-derived iPSC (induced Pluripotent Stem Cells) into relevent neurons followed by molecular characterization of the dysregulated pathways using phenotypic assays as well as genomics.
- Bhinge A, Namboori SC, Zhang X, VanDongen AMJ, Stanton LW. Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis. Stem Cell Reports. 2017 Apr 11;8(4):856-869.
- Bhinge A, Namboori SC, Bithell A, Soldati C, Buckley NJ, Stanton LW. MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration. Stem Cells. 2016 Jan;34(1):124-34.
- Bhinge A, Poschmann J, Namboori SC, Tian X, Jia Hui Loh S, Traczyk A, Prabhakar S, Stanton LW. MiR-135b is a direct PAX6 target and specifies human neuroectoderm by inhibiting TGF-β/BMP signaling. EMBO J. 2014 Jun 2;33(11):1271-83