Geoffrey Pope Lab 226
I am currently working on the synthesis and the test of new hydrogen sulfide (H2S) donor organic molecules mitochondria-targeted (and others) and on the study of the H2S release mechanism. Hydrogen sulfide has been shown to have a potential protective role in a number of disease states including diabetes and various kidney disorders and to have a major role in the regulation of a number of vital biological functions in mammals.
I graduated in Chemistry and I have always had a particular interest in Organic Chemistry and organic synthesis. I worked for 6 months at the KU-Leuven University (Belgium). My project at KU-Leuven involved: reactions under homogeneous and under heterogeneous phase catalyzed by silver salts and silver nanoparticles; reaction assisted by microwave. In my experimental thesis, that I carried out at the University of Torino (Italy), I synthesized and tested a new organic Brønsted acid chiral catalysts.
Karwi Q.G., Bornbaum J., Boengler K., Torregrossa R., Whiteman M., Wood M.E., Schulz R., Baxter G.F., AP39, A mitochondria-targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling. Br. J. Pharm., 2017, 4, 287-301.
Gerö D., Torregrossa R., Perry A., Waters A., Le Trionnaire S., Whatmore J.J.,. Wood M.E, Whiteman M., The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharm. Res., 2016,113, 186-198.
Coavoy-Sánchez S.A., Rodrigues L., Teixeira S.A., Torregrossa R., Wood M.E., Whiteman M., Costa S.K.P., Muscará M.N., Hydrogen sulfide donors alleviate itch secondary to the activation of type-2 protease activated receptors (PAR-2) in mice. Pharm. Res., 2016, 113, 686-694.
Lobb I., Jiang J., Lian D., Liu W., Haig A., Saha M.N, Torregrossa R., Wood M.E., Whiteman M., Sener A., Hydrogen sulfide protects renal grafts against prolonged cold ischemia-reperfusion injury via specific mitochondrial actions. Am. J. Transplant., 2016, 17, 341-352.
Karw Q. G., Whiteman M., Wood M. E., Torregrossa R., Baxter G. F., Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137. Pharm. Res., 2016, 111, 442–451.
Lin S., Visram F., Liu, W., Haig A., Jiang J., Mok A., Lian D., Wood M. E., Torregrossa R., Whiteman M., Lobb I., Sener A., GYY4137, a Slow-Releasing Hydrogen Sulfide Donor, Ameliorates Renal Damage Associated with Chronic Obstructive Uropathy. The J. of Urology, 2016, 196, 1778–1787.
Wedmann R., Onderka C., Wei S., Szijártó I. A., Miljkovic J. Lj., Mitrovic A., Lange M., Savitsky S., Yadav P. K., Torregrossa R., Harrer E. G., HarrerT., Ishii I., Gollasch M., Wood M. E., Galardon E., Xian M., Whiteman M., Banerjee R., Filipovic M. R., Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation. Chem. Sci., 2016, 7, 3414-3426.
Barbero M., Cadamuro S., Dughera S., Torregrossa R., Chiral derivatives of 1,2 benzenedisulfonimide as efficient Brønsted acid catalysts in the Strecker reaction. Org. Biomo. Chem., 2014, 12, 3902-3911.
Talk at Mitochondria: Form and function (BPS Conference) 14-15 September 2017, London.Talk title: Evaluation of a novel mitochondria-targeted peptide-based H2S donor compound (RTP-10) in hyperglycaemia-induced microvascular endothelial cell dysfunction
Presentation of a poster at the 67th Annual British Microcirculation Society (BMS) Meeting, 3rd-4th April 2017, University of Birmingham, UK. Poster title: Synthesis and evaluation of a novel mitochondria-targeted peptide based H2S donor compound (RTP-10) in hyperglycaemia-induced microvascular endothelial cell dysfunction.
Presentation of a poster at the, 31st Annual Royal Society of Chemistry Postgraduate Symposium, 20th September 2016, Sygnature Discovery, BioCity, Nottingham, UK. Poster Title: Synthesis of Novel Mitochondria-Targeted Hydrogen Sulfide Donor Molecules.
Partecipation at the 18th SIGMA-ALDRICH Organic Synthesis Meeting, 4th-5th December 2014, Blankenberge, Belgium.
Presentation of a poster at the GIFC Italian-French Chemistry Meeting, 5th-6th May 2014 Torino,Italy.
Poster Title: Chiral Derivatives of 1,2-Benzenedisulfonimide as Efficient Brønsted Acid Catalysts in the Strecker reaction.
- Phd Student. Medical School (Exeter University, UK)
- 2013 (Msc). Advanced Chemical Methodologies (University of Torino, Italy)
- 2011 (Bsc). Chemistry (University of Catania, Italy)