COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

Loading content

Megan Stevens

Research Fellow

 01392 72 5928

 

Overview

During my BSc degree in Physiology and the University of Bristol, I took a special interest in alternative splicing. From there I applied for a PhD position in Bristol with Prof Dave Bates (now working at Nottingham University), Prof Steve Harper (Bristol), and Dr Sebastian Oltean (now working at the University of Exeter), to study alternative splicing of VEGF-A in chronic kidney disease. After finishing my PhD, I had developed an interest in the manipulation of VEGF-A splicing in diabetic nephropathy and continued to do a Post-doc with Dr Sebastian Oltean in Bristol. Since July 2017, I have a Research Fellow position at the University of Exeter to continue working with Dr Sebatian Oltean.

I am working on grants/funding obtained by Dr Sebastian Oltean from the BHF, Richard Bright VEGF Research Trust, and Boehringer Ingelheim.

Qualifications

  • PhD in Glomerular Physiology and Alternative Splicing (University of Bristol, 2011-2014).
  • BSc in Physiology (University of Bristol, 2008-2011).

Research

Research interests

I am interested in alternative splicing in kidney disease, specifically, diabetic nephropathy. Much of our research has been focused on VEGF-A alternative splicing; however, our goals are to determine other proteins that are alternatively spliced in diabetic nephropathy, and to find ways to regulate the way these proteins are spliced as a novel therapeutic avenue.

 

Research projects

I am currently working on 2 projects with Dr Sebastian Oltean:

1. Alternative splicing in diabetic nephropathy.

2. Detection of genomic mutations in blood and urine free circulating tumour DNA in inoperable and metastatic lung adenocarcinoma harboring an EGFR mutation on tissue.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Stevens M, Oltean S (In Press). Assessment of Kidney Function in Mouse Models of Glomerular Disease. J Vis Exp(136). Abstract.  Author URL.  Full text.
Stevens M, Oltean S (2018). Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease. Genes (Basel), 9(2). Abstract.  Author URL.  Full text.

Publications by year


In Press

Stevens M, Oltean S (In Press). Assessment of Kidney Function in Mouse Models of Glomerular Disease. J Vis Exp(136). Abstract.  Author URL.  Full text.

2018

Stevens M, Oltean S (2018). Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease. Genes (Basel), 9(2). Abstract.  Author URL.  Full text.

Megan_Stevens Details from cache as at 2018-12-16 16:21:03

Refresh publications

External Engagment and Impact

Editorial responsibilities

  • I am on the editorial board for the International Journal of Renal Diseases and Therapy.

Invited lectures

  • The International Splicing Conference 2016, Lisbon.
  • The international Splicing Conference 2018, Lisbon (confirmed invited speaker).

Teaching

Supervision / Group

Back | Edit Profile