COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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 Matthew Wakeling

Matthew Wakeling

Research Fellow

 01392 408237

 RILD Building Floor 3

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Matthew graduated with a BA (and MA) in Computer Science from the University of Cambridge. Immediately following this, he worked for two years in an internet shopping startup company, before returning to the university to work for the Department of Genetics in the FlyMine group for eight years. He then studied for his engineering doctorate with the University of Surrey and the Met Office. Matthew has developed a keen interest in data analysis and efficient software algorithms for processing data. He has been working in the monogenic diabetes group in the university medical school since 2015.

In his spare time Matthew enjoys music, gardening, DIY and mountain walking.

Qualifications

  • BA, MA University of Cambridge
  • EngD University of Surrey

Research

Research interests

Software engineering, data structures and algorithms, databases, data processing, performance optimisation, nonlinear minimisation, variational data assimilation.

Publications

Key publications | Publications by category | Publications by year

Key publications


Stals KL, Wakeling M, Baptista J, Caswell R, Parrish A, Rankin J, Tysoe C, Jones G, Gunning AC, Lango Allen H, et al (In Press). Diagnosis of lethal or prenatal-onset autosomal recessive disorders by parental exome sequencing. Prenat Diagn, 38(1), 33-43. Abstract.  Author URL.
Iacovazzo D, Flanagan S, Walker E, Quezado R, Antonio de Sousa F, Caswell R, Johnson MBJ, Wakeling M, Brandle M, Guo M, et al (2018). A MAFA missense mutation causes familial insulinomatosis and diabetes mellitus. Proceedings of the National Academy of Sciences Full text.

Publications by category


Journal articles

Laver TW, Wakeling M, Hua JHY, Houghton J, Hussain K, Ellard S, Flanagan S (In Press). Comprehensive screening shows that mutations in the known syndromic genes are rare in infants presenting with hyperinsulinaemic hypoglycaemia. Clinical Endocrinology Full text.
Stals KL, Wakeling M, Baptista J, Caswell R, Parrish A, Rankin J, Tysoe C, Jones G, Gunning AC, Lango Allen H, et al (In Press). Diagnosis of lethal or prenatal-onset autosomal recessive disorders by parental exome sequencing. Prenat Diagn, 38(1), 33-43. Abstract.  Author URL.
Iacovazzo D, Flanagan S, Walker E, Quezado R, Antonio de Sousa F, Caswell R, Johnson MBJ, Wakeling M, Brandle M, Guo M, et al (2018). A MAFA missense mutation causes familial insulinomatosis and diabetes mellitus. Proceedings of the National Academy of Sciences Full text.
Wakeling MN, Laver TW, Wright CF, De Franco E, Stals KL, Patch A-M, Hattersley AT, Flanagan SE, Ellard S, DDD Study, et al (2018). Correction: Homozygosity mapping provides supporting evidence of pathogenicity in recessive Mendelian disease. Genet Med Abstract.  Author URL.
Wakeling MN, Laver TW, Wright CF, De Franco E, Stals KL, Patch A-M, Hattersley AT, Flanagan SE, Ellard S, DDD Study, et al (2018). Homozygosity mapping provides supporting evidence of pathogenicity in recessive Mendelian disease. Genet Med Abstract.  Author URL.  Full text.
Low KJ, Stals K, Caswell R, Wakeling M, Clayton-Smith J, Donaldson A, Foulds N, Norman A, Splitt M, Urankar K, et al (2018). Phenotype of CNTNAP1: a study of patients demonstrating a specific severe congenital hypomyelinating neuropathy with survival beyond infancy. Eur J Hum Genet, 26(6), 796-807. Abstract.  Author URL.
Iacovazzo D, Flanagan SE, Walker E, Caswell R, Brandle M, Johnson M, Wakeling M, Guo M, Dang MN, Gabrovska P, et al (2016). A missense mutation in the islet-enriched transcription factor MAFA leads to familial insulinomatosis and diabetes. Endocrine Abstracts
Wakeling M, Eyre J, Hughes S, Roulstone I (2014). Assimilation of vertical motion from simulated cloudy satellite imagery in an idealized single column model. Quarterly Journal of the Royal Meteorological Society Abstract.
Smith RN, Aleksic J, Butano D, Carr A, Contrino S, Hu F, Lyne M, Lyne R, Kalderimis A, Rutherford K, et al (2012). InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics, 28(23), 3163-3165. Abstract.  Author URL.
Lyne R, Smith R, Rutherford K, Wakeling M, Varley A, Guillier F, Janssens H, Ji W, Mclaren P, North P, et al (2007). FlyMine: an integrated database for Drosophila and Anopheles genomics. Genome Biol, 8(7). Abstract.  Author URL.

Conferences

De Franco E, Lytrivi M, Patel K, Igoillo-Esteve M, Wakeling M, Haliloglu B, Unal E, Godbole T, Yildiz M, Ellard S, et al (2018). Mutations in YIPF5 are a novel cause of neonatal diabetes, highlighting the critical role of endoplasmic reticulum-to-Golgi trafficking in human beta cell survival.  Author URL.
Laver T, Wakeling M, Knox O, De-Franco E, Flanagan S, Colclough K, Ellard S, Hattersley A, Weedon M, Patel K, et al (2018). Redefining the pathogenicity of Maturity Onset Diabetes of the Young (MODY) genes: BLK, PAX4 and KLF11 do not cause MODY.  Author URL.
Janssens H, Lyne R, Smith R, Guillier F, Ji W, McLaren P, Riley T, Reisinger F, Rutherford K, Wakeling M, et al (2006). Flymine: an integrated database of Drosophila and anopheles genomics.  Author URL.

Publications by year


In Press

Laver TW, Wakeling M, Hua JHY, Houghton J, Hussain K, Ellard S, Flanagan S (In Press). Comprehensive screening shows that mutations in the known syndromic genes are rare in infants presenting with hyperinsulinaemic hypoglycaemia. Clinical Endocrinology Full text.
Stals KL, Wakeling M, Baptista J, Caswell R, Parrish A, Rankin J, Tysoe C, Jones G, Gunning AC, Lango Allen H, et al (In Press). Diagnosis of lethal or prenatal-onset autosomal recessive disorders by parental exome sequencing. Prenat Diagn, 38(1), 33-43. Abstract.  Author URL.

2018

Iacovazzo D, Flanagan S, Walker E, Quezado R, Antonio de Sousa F, Caswell R, Johnson MBJ, Wakeling M, Brandle M, Guo M, et al (2018). A MAFA missense mutation causes familial insulinomatosis and diabetes mellitus. Proceedings of the National Academy of Sciences Full text.
Wakeling MN, Laver TW, Wright CF, De Franco E, Stals KL, Patch A-M, Hattersley AT, Flanagan SE, Ellard S, DDD Study, et al (2018). Correction: Homozygosity mapping provides supporting evidence of pathogenicity in recessive Mendelian disease. Genet Med Abstract.  Author URL.
Wakeling MN, Laver TW, Wright CF, De Franco E, Stals KL, Patch A-M, Hattersley AT, Flanagan SE, Ellard S, DDD Study, et al (2018). Homozygosity mapping provides supporting evidence of pathogenicity in recessive Mendelian disease. Genet Med Abstract.  Author URL.  Full text.
De Franco E, Lytrivi M, Patel K, Igoillo-Esteve M, Wakeling M, Haliloglu B, Unal E, Godbole T, Yildiz M, Ellard S, et al (2018). Mutations in YIPF5 are a novel cause of neonatal diabetes, highlighting the critical role of endoplasmic reticulum-to-Golgi trafficking in human beta cell survival.  Author URL.
Low KJ, Stals K, Caswell R, Wakeling M, Clayton-Smith J, Donaldson A, Foulds N, Norman A, Splitt M, Urankar K, et al (2018). Phenotype of CNTNAP1: a study of patients demonstrating a specific severe congenital hypomyelinating neuropathy with survival beyond infancy. Eur J Hum Genet, 26(6), 796-807. Abstract.  Author URL.
Laver T, Wakeling M, Knox O, De-Franco E, Flanagan S, Colclough K, Ellard S, Hattersley A, Weedon M, Patel K, et al (2018). Redefining the pathogenicity of Maturity Onset Diabetes of the Young (MODY) genes: BLK, PAX4 and KLF11 do not cause MODY.  Author URL.

2016

Iacovazzo D, Flanagan SE, Walker E, Caswell R, Brandle M, Johnson M, Wakeling M, Guo M, Dang MN, Gabrovska P, et al (2016). A missense mutation in the islet-enriched transcription factor MAFA leads to familial insulinomatosis and diabetes. Endocrine Abstracts

2014

Wakeling M, Eyre J, Hughes S, Roulstone I (2014). Assimilation of vertical motion from simulated cloudy satellite imagery in an idealized single column model. Quarterly Journal of the Royal Meteorological Society Abstract.

2012

Smith RN, Aleksic J, Butano D, Carr A, Contrino S, Hu F, Lyne M, Lyne R, Kalderimis A, Rutherford K, et al (2012). InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics, 28(23), 3163-3165. Abstract.  Author URL.

2007

Lyne R, Smith R, Rutherford K, Wakeling M, Varley A, Guillier F, Janssens H, Ji W, Mclaren P, North P, et al (2007). FlyMine: an integrated database for Drosophila and Anopheles genomics. Genome Biol, 8(7). Abstract.  Author URL.

2006

Janssens H, Lyne R, Smith R, Guillier F, Ji W, McLaren P, Riley T, Reisinger F, Rutherford K, Wakeling M, et al (2006). Flymine: an integrated database of Drosophila and anopheles genomics.  Author URL.

Matthew_Wakeling Details from cache as at 2018-12-16 14:57:01

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