Dr Kim Gooding
Postdoctoral Research Fellow
Diabetes and Vascular Research Centre
Dr Kim Gooding graduated with a degree in Biomedical Science and was awarded a PhD in Medical Sciences from the University of Exeter. Kim is a senior member of the Diabetes and Vascular Medicine Research team within the NIHR Exeter Clinical Research Facility. In addition to her research
Kim’s research is primarily focused on examining the relationship between microvascular endothelial function and the vascular complications associated with type 2 diabetes and prediabetes. She also works closely with the Patient Public Involvement groups within the NIHR Exeter Clinical Research Facility.
- PhD in Medical Science
- BSc (Hons) in Biomedical Science
Kim’s research interests are to develop, lead and collaborate on a programme of work to examine the relationship between microvascular function and the vascular complications associated with type 2 diabetes and prediabetes, with particular interests in (1) the underlying pathogenesis of diabetic retinopathy and nephropathy, and whether novel imaging biomarkers may help identify individuals at risk of these complications and (2) the vascular actions of incretin based therapies.
Recent research activities have included being the co-lead on the multi-centre Diabetic Retinopathy imaging study that forms part of the Innovative Medicines Initiative (IMI) funded SUMMIT consortium. She also actively contributes to the development and management of multi-centre study funded by IMI investigating prognostic imaging biomarkers for diabetic kidney disease.
Her programme of studies examining the microvascular actions of incretin based medications, including the DPP-IV inhibitors and GLP-1 receptor agonists, has been funded by Diabetes UK and has utilised a multi-disciplinary approach using in vitro, ex vivo and clinical studies approaches.
- The vascular actions of glucagon-like peptide-1 analogues and its mediators in people with type 2 diabetes and diabetic retinopathy (VIBE study).
- Examining the relationship between blood vessel health and kidney function in people with and without diabetes (BEAT-DKD Exeter).
- The role of SGLT-2 co-transporter inhibitors on metabolite utilisation in people with type 2 diabetes (DAMES study).
- An investigation into the mechanisms of action of incretin based anti-diabetic therapies in the human vasculature.
- Is the glycocalyx marker, hyaluronic acid, associated with early signs of diabetic retinopathy, macular thickening and albuminuria?
- Examining whether subtle changes in the retina are associated with vascular complications in people with type 2 diabetes.
- Diabetes UK: The vascular actions of glucagon-like peptide-1 analogues and its mediators in people with type 2 diabetes and diabetic retinopathy (VIBE study).
- Innovative Medicines Initiative (IMI): Examining the relationship between blood vessel health and kidney function in people with and without diabetes (BEAT-DKD Exeter).
- Astra Zeneca: The role of SGLT-2 co-transporter inhibitors on metabolite utilisation in people with type 2 diabetes (DAMES study).
- Diabetes UK: An investigation into the mechanisms of action of incretin based anti-diabetic therapies in the human vasculature.
- Northcott Devon Medical Foundation: Is the glycocalyx marker, hyaluronic acid, associated with early signs of diabetic retinopathy, macular thickening and albuminuria?
Metformin is the key factor in elevated plasma growth differentiation factor-15 levels in type 2 diabetes: A nested, case-control study. Natali A, Nesti L, Venturi E, Shore AC, Khan F, Gooding K, Gates PE, Looker HC, Dove F, Goncalves I, Persson M, Nilsson J; SUMMIT consortium. Diabetes Obes Metab. 2018 Sep 3. doi: 10.1111/dom.13519.
Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study. Shore AC, Colhoun HM, Natali A, Palombo C, Khan F, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, Gates PE, Looker H, Dove F, Belch J, Pinnola S, Venturi E, Kozakova M, Goncalves I, Kravic J, Björkbacka H, Nilsson J; SUMMIT Consortium. Diabetes Care. 2018;41(10):2212-2219.
The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control. Casanova F, Adingupu DD, Adams F, Gooding KM, Looker HC, Aizawa K, Dove F, Elyas S, Belch JJF, Gates PE, Littleford RC, Gilchrist M, Colhoun HM, Shore AC, Khan F, Strain WD. Cardiovasc Diabetol. 2017;16(1):114. doi: 10.1186/s12933-017-0594-7.
GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction. Pastel E, McCulloch LJ, Ward R, Joshi S, Gooding KM, Shore AC, Kos K. Clin Sci (Lond). 2017;131(5):343-353.
Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. Gonçalves I, Edsfeldt A, Colhoun HM, Shore AC, Palombo C, Natali A, Fredrikson GN, Björkbacka H, Wigren M, Bengtsson E, Östling G, Aizawa K, Casanova F, Persson M, Gooding K, Gates P, Khan F, Looker HC, Adams F, Belch J, Pinnola S, Venturi E, Kozakova M, Gan LM, Schnecke V, Nilsson J; SUMMIT consortium. BMC Cardiovasc Disord. 2016 ;16(1):171. doi: 10.1186/s12872-016-0346-8
Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE. Physiol Rep. 2016 Jun;4(12). pii: e12808. doi: 10.14814/phy2.12808.
Red Blood Cell Susceptibility to Pneumolysin: correlation with membrane biochemical and physical properties. Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, Winlove CP. J Biol Chem. 2016;291(19):10210-27.
Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE. Ultrasound Med Biol. 2016 ;42(5):1130-7.
Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 Diabetes. Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, Östling G, Aizawa K, Casanova F, Persson M, Gooding K, Strain D, Khan F, Looker HC, Adams F, Belch J, Pinnoli S, Venturi E, Kozakova M, Gan LM, Schnecke V, Nilsson J; SUMMIT Consortium. Arterioscler Thromb Vasc Biol. 2015;35(7):1723-31.
Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study. Shore AC, Colhoun HM, Natali A, Palombo C, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, Gates PE, Khan F, Looker HC, Adams F, Belch J, Pinnoli S, Venturi E, Morizzo C, Goncalves I, Ladenvall C, Nilsson J; SUMMIT consortium. J Intern Med. 2015;278(3):291-302.
Blood Oxygen Saturation After Ischemia is Altered With Abnormal Microvascular Reperfusion. Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW. Microcirculation. 2015;22(4):294-305.
Ethnic differences in microvascular function in apparently healthy South African men and women. Pienaar PR, Micklesfield LK, Gill JM, Shore AC, Gooding KM, Levitt NS, Lambert EV. Exp Physiol. 2014;99(7):985-94.
Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG. Ann N Y Acad Sci. 2010;1203:146-50.
Capillary pressure may predict preclinical changes in the eye. Gooding KM, Tooke JE, von Lany H, Mitra M, Ling R, Ball CI, Mawson D, Skinner K, Shore AC. Diabetologia. 2010;53(9):2029-35.
Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC.Diabetologia. 2010;53(8):1722-6.
Variability in sublingual microvessel density and flow measurements in healthy volunteers. Hubble SM, Kyte HL, Gooding K, Shore AC. Microcirculation. 2009;16(2):183-91.
The insulin sensitiser pioglitazone does not influence skin microcirculatory function in patients with type 2 diabetes treated with insulin. Tooke JE, Elston LM, Gooding KM, Ball CI, Mawson DM, Piper J, Sriraman R, Urquhart R, Shore AC. Diabetologia. 2006;49(5):1064-70.
Maximum skin hyperaemia induced by local heating: possible mechanisms. Gooding KM, Hannemann MM, Tooke JE, Clough GF, Shore AC. J Vasc Res. 2006;43(3):270-7.
Impact of hormone replacement therapy on microvascular function in healthy and Type 2 diabetic postmenopausal women. Gooding KM, MacLeod KM, Spyer G, Ewings P, Tooke JE, Shore AC. Diabet Med. 2005;22(5):536-42.
Serum amino acids in patients with mutations in the hepatocyte nuclear factor-1 alpha gene. Stride A, Pearson ER, Brown A, Gooding K, Castleden HA, Hattersley AT. Diabet Med. 2004;21(8):928-30.
Capillary pressure in subjects with type 2 diabetes and hypertension and the effect of antihypertensive therapy. Fegan PG, Tooke JE, Gooding KM, Tullett JM, MacLeod KM, Shore AC. Hypertension. 2003;41(5):1111-7.
External Engagement and Impact
- British Microcirculation Society Poster Award 2009
Kim is an active member of national and European societies for the microcirculation. Her involvement in the British Microcirculation Society includes:
- Membership Secretary for the British Microcirculation Society (2014-2018)
- Organising committee for the annual Society meetings in 2010 and 2019.
- Chairing sessions and acting as poster judge at the annual meetings.
Kim is also a member of the Diabetes UK and the European Association for the Study of Diabetes.
TeachingTeaching responsibilities: (Undergraduate, Postgraduate)
Current postgraduate supervision
Andrew Forbes Brown (Thesis title: Cross-sectional analysis of microvascular health in type 2 diabetic patients at differing stages of kidney function).
Natalia Rolinska (Thesis title: Examining whether subtle changes in the retina are associated with vascular complications in people with type 2 diabetes).
Leighton Freeman (Thesis title: An investigation into the mechanisms of action of incretin based anti-diabetic therapies in the human vasculature).
Undergraduate teaching responsibilities
BSc Medical Sciences
Final year project provider
Professional training year supervisor
Research in action special study unit provider