University of Exeter Medical School

Jonathan Locke

Jonathan Locke

Lecturer in Medical Sciences

 J.Locke@exeter.ac.uk

 RILD Building Level 3

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Dr Locke received a Masters of Biology in Molecular & Cellular Biology from the University of Bath in 2006. Following this, he obtained a PhD from the Peninsula Medical School (Universities of Exeter & Plymouth) under the supervision of Dr Lorna Harries. Following completion of his PhD he has continued to work in the area of diabetes genetics. Please see Research tab for further details.

Dr Locke teaches on the MSc Genomic Medicine and BSc Medical Sciences programmes. 

Qualifications

  • Fellow of the Higher Education Academy, University of Exeter
  • PhD (Medical Studies), Peninsula Medical School, Universities of Exeter & Plymouth
  • Master of Biology (MBiol) Molecular & Cellular Biology, University of Bath

Back to top

Research

Research interests

Dr Locke is interested in translating advances in our understanding of the genetics of diabetes into clinical benefit. As such he is currently involved in projects to develop novel assays to calculate the T1D-GRS for diabetes classification.

Research projects

 

Back to top

Publications

Journal articles

Locke JM, da Silva Xavier G, Rutter, GA, Harries LW (In Press). An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia Abstract.
Oram RA, Weedon M, Wood A, Beaumont R, Tyrrell J (In Press). Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis. Diabetes Care
Ruth KS, Beaumont RN, Locke JM, Tyrrell J, Crandall CJ, Hawkes G, Frayling TM, Prague JK, Patel KA, Wood AR, et al (2023). Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records. BMC Med Genomics, 16(1). Abstract.  Author URL.
SHARP SA, LOCKE JM, XU Y, FRASER DP, FERRAT LA, WEEDON MN, INOUYE M, ORAM RA, HAGOPIAN W (2022). 188-LB: Deep Learning–Based Population Screening of Type 1 Diabetes and Celiac Disease Genetic Risk from Blood Spots at Birth. Diabetes, 71(Supplement_1).
Locke JM, Dusatkova P, Colclough K, Hughes AE, Dennis JM, Shields B, Flanagan SE, Shepherd MH, Dempster EL, Hattersley AT, et al (2022). Association of birthweight and penetrance of diabetes in individuals with HNF4A-MODY: a cohort study. Diabetologia, 65(1), 246-249.  Author URL.
Sioofy-Khojine A-B, Richardson SJ, Locke JM, Oikarinen S, Nurminen N, Laine A-P, Downes K, Lempainen J, Todd JA, Veijola R, et al (2022). Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage. Diabetologia, 65(10), 1701-1709. Abstract.
Montaser H, Patel KA, Balboa D, Ibrahim H, Lithovius V, Näätänen A, Chandra V, Demir K, Acar S, Ben-Omran T, et al (2021). Loss of MANF Causes Childhood-Onset Syndromic Diabetes Due to Increased Endoplasmic Reticulum Stress. Diabetes, 70(4), 1006-1018. Abstract.  Author URL.
Locke JM, Latten MJ, Datta RY, Wood AR, Crockard MA, Lamont JV, Weedon MN, Oram RA (2020). Methods for quick, accurate and cost-effective determination of the type 1 diabetes genetic risk score (T1D-GRS). Clin Chem Lab Med, 58(4), e102-e104.  Author URL.
Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.
Locke JM, Saint-Martin C, Laver TW, Patel KA, Wood AR, Sharp SA, Ellard S, Bellanné-Chantelot C, Hattersley AT, Harries LW, et al (2018). The Common HNF1A Variant I27L is a Modifier of Age at Diabetes Diagnosis in Individuals with HNF1A-MODY. Diabetes, 67(9), 1903-1907. Abstract.  Author URL.
Lee BP, Lloyd-Laney HO, Locke JM, McCulloch LJ, Knight B, Yaghootkar H, Cory G, Kos K, Frayling TM, Harries LW, et al (2016). Functional characterisation of ADIPOQ variants using individuals recruited by genotype. Mol Cell Endocrinol, 428, 49-57. Abstract.  Author URL.
Tugay K, Guay C, Marques AC, Allagnat F, Locke JM, Harries LW, Rutter GA, Regazzi R (2016). Role of microRNAs in the age-associated decline of pancreatic beta cell function in rat islets. Diabetologia, 59(1), 161-169. Abstract.
Locke JM, Wei FY, Tomizawa K, Weedon MN, Harries LW (2015). A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia, 58(4), 745-748. Abstract.
Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW (2015). Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes, 64(4), 1484-1491. Abstract.  Author URL.
Locke JM, Lango Allen H, Harries LW (2014). A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells. Acta Diabetologica, 51(2), 325-329. Abstract.
Locke JM, Da Silva Xavier G, Dawe HR, Rutter GA, Harries LW (2014). Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion. Diabetologia, 57(1), 122-128. Abstract.
aer M, Jonathan L, Anna M, Lorna WH (2013). Expression profiling of putative type 2 diabetes susceptibility genes in human islets and in rat beta cell lines. Journal of Diabetes Mellitus, 03(01), 27-32.
Morrison F, Locke J, Arif M, Murray A, Brown JE, Harries LW (2013). Expression profiling of type 2 diabetes susceptibility genes in the pancreatic islets, adipose tissue and liver of obese mice. Exp Clin Endocrinol Diabetes, 121(7), 413-419. Abstract.  Author URL.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract.  Author URL.
Locke JM, Harries LW (2012). MicroRNA expression profiling of human islets from individuals with and without type 2 diabetes: promises and pitfalls. Biochem Soc Trans, 40(4), 800-803. Abstract.  Author URL.
Morrison F, Johnstone K, Murray A, Locke J, Harries LW (2012). Oxidative metabolism genes are not responsive to oxidative stress in rodent beta cell lines. Experimental Diabetes Research, 2012 Abstract.
Locke JM, Da Silva Xavier G, Rutter GA, Harries LW (2011). Erratum to: an alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes. Diabetologia, 54(12).
Flanagan SE, Patch A-M, Locke JM, Akcay T, Simsek E, Alaei M, Yekta Z, Desai M, Kapoor RR, Hussain K, et al (2011). Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees. J Clin Endocrinol Metab, 96(3), E498-E502. Abstract.  Author URL.
Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, Del Castillo G, et al (2010). Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 107(7), 3105-3110. Abstract.
Locke JM, Ellard S, Norwood VF, Harries LW (2009). Variants in the isoform-specific coding regions of the <i>HNF1A, HNF4A</i> and <i>HNF1B</i> genes are not a common cause of familial, young-onset diabetes or renal cysts and diabetes (RCAD). DIABETIC MEDICINE, 26(5), 570-570.  Author URL.
Kapoor RR, Locke J, Colclough K, Wales J, Conn JJ, Hattersley AT, Ellard S, Hussain K (2008). Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations. Diabetes, 57(6), 1659-1663. Abstract.  Author URL.
Locke JM, Harries LW (2008). RNA processing and mRNA surveillance in monogenic diabetes. Gene Regul Syst Bio, 2, 203-212. Abstract.  Author URL.
Harries LW, Locke JM, Shields B, Hanley NA, Hanley KP, Steele A, Njølstad PR, Ellard S, Hattersley AT (2008). The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development. Diabetes, 57(6), 1745-1752. Abstract.  Author URL.

Conferences

Locke JM, Patel KA, Shepherd MH, Ellard S, Weedon MN (2018). Expression of Maturity-Onset Diabetes of the Young (MODY) genes in accessible human tissues.  Author URL.

Back to top

Teaching

Teaching responsibilities: (Undergraduate, Postgraduate)

  • Co-Module Lead for Fundamentals in Human Genetics and Genomics (HPDM082A) on MSc Genomic Medicine programme
  • Educator on Medical Genomics (CSC3011) on BSc Medical Sciences programme
  • Academic Tutor on MSc Genomic Medicine and BSc Medical Sciences programmes

Modules

2023/24


Back to top

Edit Profile