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 John Dennis

John Dennis

Postgraduate Research Assistant and PhD student

 07734 940921

 South Cloisters 

 

South Cloisters, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK

John is a PhD student and graduate researcher at the University of Exeter Medical School. He joined the Health Statistics group as a part-time PhD student in October 2014, under Professor William Henley, Dr Beverley Shields and Professor Andrew Hattersley. In January 2018 he joined Professor Hattersley’s diabetes research team full-time.

His research focuses on developing a stratified or ‘precision’ approach to drug therapy in type 2 diabetes, a condition for which there are many different drug options but little guidance to help clinicians and patients choose between them. John is applying advanced statistical methods to better understand the benefits and risks of each drug option, in particular which patients are likely to have the best response and/or lowest risk of side effects, and to what extent response and side-effects go hand-in-hand. He was awarded runner-up in the Diabetes UK Type 2 Diabetes Research Prize in 2017 and won the Diabetes UK Lily Clinical Science Poster Award in 2015.

John is also developing a more general methodological framework for precision medicine research using as a first discovery step ‘big’ data from routine clinical practice (the UK’s CPRD), followed by validation of findings in individual participant data from existing randomised trials available from Clinical Study Data Request and the YODA Project.

John trained at the London School of Hygiene & Tropical Medicine and has 5 years’ experience as a health researcher in the financial services industry, where he specialised in longevity modelling. He has also worked a research analyst for the Cancer Council in Australia and for the NHS in the UK. Across these roles he developed his interest in applied statistical research and chronic disease epidemiology that led him to Professor Hattersley’s team at the University of Exeter.

Qualifications

MSc Control of Infectious Diseases (London School of Hygiene and Tropical Medicine)

BSc (Hons) Psychology (University of Nottingham)

Research

Research interests

  • Precision/Stratified medicine: Stratification of therapy in type 2 diabetes as part of the MRC-funded APBI Stratification and Extreme Response Mechanism IN Diabetes (MASTERMIND) consortium
  • Joint longitudinal-survival modelling
  • Clinical prediction models
  • Longevity modelling
  • Methods to strengthen inference from routine clinical practice databases

Research projects

MRC-funded APBI Stratification and Extreme Response Mechanism IN Diabetes (MASTERMIND) consortium.

Key publications | Publications by category | Publications by year

Key publications


Dennis J, Shields B, Hill A, Knight B, McDonald T, Rodgers L, Weedon M, Henley W, Sattar N, Holman R, et al (2018). Precision medicine in Type 2 diabetes: Clinical markers of insulin resistance are associated with altered short and long-term glycemic response to DPP4-inhibitor therapy. Diabetes Care Full text.

Publications by category


Journal articles

Dennis J, Shields B, Hill A, Knight B, McDonald T, Rodgers L, Weedon M, Henley W, Sattar N, Holman R, et al (2018). Precision medicine in Type 2 diabetes: Clinical markers of insulin resistance are associated with altered short and long-term glycemic response to DPP4-inhibitor therapy. Diabetes Care Full text.
Harris JD, Little CJL, Dennis JM, Patteson MW (2017). Heart rate turbulence after ventricular premature beats in healthy Doberman pinschers and those with dilated cardiomyopathy. J Vet Cardiol, 19(5), 421-432. Abstract.  Author URL.
Dennis J, Crayford T (2015). Parliamentary privilege—mortality in members of the Houses of Parliament compared with the UK general population: retrospective cohort analysis, 1945-2011. BMJ, h6563-h6563.

Publications by year


2018

Dennis J, Shields B, Hill A, Knight B, McDonald T, Rodgers L, Weedon M, Henley W, Sattar N, Holman R, et al (2018). Precision medicine in Type 2 diabetes: Clinical markers of insulin resistance are associated with altered short and long-term glycemic response to DPP4-inhibitor therapy. Diabetes Care Full text.

2017

Harris JD, Little CJL, Dennis JM, Patteson MW (2017). Heart rate turbulence after ventricular premature beats in healthy Doberman pinschers and those with dilated cardiomyopathy. J Vet Cardiol, 19(5), 421-432. Abstract.  Author URL.

2015

Dennis J, Crayford T (2015). Parliamentary privilege—mortality in members of the Houses of Parliament compared with the UK general population: retrospective cohort analysis, 1945-2011. BMJ, h6563-h6563.

John_Dennis Details from cache as at 2018-04-24 15:54:32

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Awards

  • Poster prize runner-up. Statistical analysis of multi-outcome data conference, 2017
  • Diabetes UK Type 2 diabetes research award runner-up. Diabetes UK professional conference, 2017
  • Diabetes UK Lily Clinical Science Poster Award, Diabetes UK professional conference, 2015

Media Coverage

Feb 2018: Precision medicine in type 2 diabetes: Insulin resistance markers associated with DPP-IV inhibitor response in type 2 diabetes

Feb 2018: Diabetes: Clinical markers of glycaemic response to DPP4 inhibitor therapy

Dec 2015: New perk for MPs: longer life

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