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Dr Jessica Tyrrell

Dr Jessica Tyrrell

Lecturer

 01392408262

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Jess is a Lecturer at the University of Exeter Medical School. Her main research interest involves using genetics to explore causal relationships to improve our understanding of type 2 diabetes and related metabolic disorders. In addition to her research interest in metabolic disorders, she also researches vestibular conditions of the inner ear, including Meniere's disease. 

The majority of her research utilises the UK Biobank data set which has over 500,000 people and as such is a very powerful epidemiological resource. Dr Tyrrell is utilising this data to understand what factors (e.g. lifestyle - diet, exercise etc. and biochemical - lipids, hormones) may be causally associated with type 2 diabetes. This work utilises a genetic technique known as Mendelian randomisation.

 

Research

Research projects

Investigating the causal role of a range of factors (e.g. sleep, diet) and biomarkers (e.g. lipids, hormones) in the development of type 2 diabetes. 

Investigating the role of birth weight in type 2 diabetes.

Investigating factors involved in type 2 diabetes liability. 

Using genetics to identify causality in associations between maternal quantitative traits and offspring birth weight.

Investigating the genetics of vestibular disorders

Using e-health approaches to explore Meniere's Disease

 

Research grants

  • 2014 Diabetes Research and Wellness Foundation
    To use Mendelian randomization to understand the causal Relationship between circulating biomarkers and Type 2 Diabetes in the UK Biobank
  • 2014 Meniere's Society
    Living with M�ni�re�s Disease: Understanding Patient Experiences of Mental Health and Well-being.
  • 2012 Meniere's Society
    Meniere's disease in the UK Biobank

Key publications | Publications by category | Publications by year

Key publications


Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.

Publications by category


Journal articles

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (In Press). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract.  Author URL.  Full text.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (In Press). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.  Full text.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (In Press). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics Full text.
Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (In Press). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract.  Author URL.  Full text.
Schmidt W, Sarran C, Ronan N, Barrett G, Whinney DJ, Fleming LE, Osborne NJ, Tyrrell J (In Press). The Weather and Ménière's Disease: a Longitudinal Analysis in the UK. Otol Neurotol, 38(2), 225-233. Abstract.  Author URL.  Full text.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (In Press). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.  Full text.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract.  Author URL.  Full text.
Yeo NL, White MP, Ronan N, Whinney DJ, Curnow A, Tyrrell J (2018). Stress and Unusual Events Exacerbate Symptoms in Menière's Disease: a Longitudinal Study. Otol Neurotol, 39(1), 73-81. Abstract.  Author URL.  Full text.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract.  Author URL.  Full text.
Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, et al (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun, 8 Abstract.  Author URL.  Full text.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.  Full text.
Bell SL, Tyrrell J, Phoenix C (2016). A day in the life of a Ménière’s patient: understanding the lived experiences and mental health impacts of Ménière’s disease. Sociology of Health and Illness Full text.
Frayling TM, Tyrrell J (2016). Authors' reply to Toth. BMJ, 353 Author URL.
Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NMG, et al (2016). Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA, 315(11), 1129-1129. Full text.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.  Full text.
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.  Full text.
Frayling TM, Tyrrell J (2016). HEIGHT, BODY MASS INDEX, AND SOCIOECONOMIC STATUS Conclusions of study on height, body mass index, and socioeconomic status have an uncertain basis Reply. BMJ-BRITISH MEDICAL JOURNAL, 353 Author URL.  Full text.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Bell SL, Tyrrell J, Phoenix C (2016). Ménière’s disease and biographical disruption: where family transitions collide. Social Science and Medicine Full text.
Tyrrell J, Schmidt W, Williams DH, Redshaw CH (2016). Physical activity in ankylosing spondylitis: evaluation and analysis of an eHealth tool. Journal of Innovation in Health Informatics Full text.
Tyrrell J, Whinney DJ, Taylor T (2016). The Cost of Ménière's Disease: a Novel Multisource Approach. Ear Hear, 37(3), e202-e209. Abstract.  Author URL.
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Ménière's: Cross-Sectional Analysis in the UK Biobank. Ear Hear, 36(3), e122-e128. Abstract.  Author URL.
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Menière's: Cross-Sectional Analysis in the UK Biobank. Ear and Hearing, 36(3), e122-e128. Abstract.
Morris RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M, Campbell A, Marioni R, Kumari M, Korhonen T, et al (2015). Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ Open, 5(8). Abstract.  Author URL.
Tyrrell J, White M, Barrett G, Ronan N, Phoenix C, Whinney D, Osborne N (2015). Mental Health and Subjective Wellbeing of individuals with Ménière’s: Cross Sectional Analysis in the UK Biobank. Otology & Neurotology
Kendall M, Hodges NJ, Whitwell H, Tyrrell J, Cangul H (2015). Nanoparticle growth and surface chemistry changes in cell-conditioned culture medium. Philos Trans R Soc Lond B Biol Sci, 370(1661). Abstract.  Author URL.
Sharpe RA, Thornton CR, Tyrell J, Nikolaou V, Osborne NJ (2015). Variable risk of atopic disease due to indoor fungal exposure in NHANES 2005-2006. Clinical and Experimental Allergy, 45(10), 1566-1578.
Freathy RM, Tyrrell J, Bradfield JP, Cavadino A, Feenstra B, Hayes MG, Hottenga JJ, Huikari V, Kreiner-Moller E, Metrustry S, et al (2014). Genetic analyses identify positive causal effects of maternal fasting glucose, Type 2 diabetes and vitamin D levels, and an inverse causal effect of maternal blood pressure, on offspring birth weight. DIABETIC MEDICINE, 31, 18-18. Author URL.
Tyrrell JS, Whinney DJD, Ukoumunne OC, Fleming LE, Osborne NJ (2014). Prevalence, associated factors, and comorbid conditions for Ménière's disease. Ear Hear, 35(4), e162-e169. Abstract.  Author URL.
Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, et al (2014). Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genet, 10(12). Abstract.  Author URL.
Depledge MH, Tyrrell J, Fleming LE, Holgate ST (2013). Are marine environmental pollutants influencing global patterns of human disease?. Mar Environ Res, 83, 93-95. Abstract.  Author URL.
Depledge MH, Tyrrell J, Fleming LE, Holgate ST (2013). Are marine environmental pollutants influencing global patterns of human disease?. Marine Environmental Research, 83, 93-95. Abstract.
Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ (2013). Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int, 59, 328-335. Abstract.  Author URL.
Tyrrell J, Galloway TS, Abo-Zaid G, Melzer D, Depledge MH, Osborne NJ (2013). High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010. PLoS One, 8(11). Abstract.  Author URL.  Full text.
Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM (2013). Parental diabetes and birthweight in 236 030 individuals in the UK biobank study. Int J Epidemiol, 42(6), 1714-1723. Abstract.  Author URL.  Full text.
Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion M-JA, Geller F, Paternoster L, Myhre R, Potter C, et al (2012). Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet, 21(24), 5344-5358. Abstract.  Author URL.  Full text.
Tyrrell JS, Morton C, Campbell SM, Curnow A (2011). Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites. Br J Dermatol, 164(6), 1362-1368. Abstract.  Author URL.  Full text.
Tyrrell J, Campbell SM, Curnow A (2011). Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification. Photodiagnosis Photodyn Ther, 8(1), 30-38. Abstract.  Author URL.  Full text.
Tyrrell J, Thorn C, Shore A, Campbell S, Curnow A (2011). Oxygen saturation and perfusion changes during dermatological methyl-aminolevulinate photodynamic therapy. British Journal of Dermatology Full text.
Tyrrell J, Campbell SM, Curnow A (2011). The effect of air cooling pain relief on protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy. J Photochem Photobiol B, 103(1), 1-7. Abstract.  Author URL.
Campbell SM, Tyrrell J, Marshall R, Curnow A (2010). Effect of MAL-photodynamic therapy on hypertrophic scarring. Photodiagnosis Photodyn Ther, 7(3), 183-188. Abstract.  Author URL.
Tyrrell J, Campbell S, Curnow A (2010). Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy. Photodiagnosis Photodyn Ther, 7(4), 232-238. Abstract.  Author URL.
Tyrrell JS, Campbell SM, Curnow A (2010). The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome. Lasers Surg Med, 42(7), 613-619. Abstract.  Author URL.  Full text.
Tyrrell J, Campbell S, Curnow A (2010). Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT. Photodiagnosis Photodyn Ther, 7(2), 86-97. Abstract.  Author URL.  Full text.
Prosser BE, Johnson S, Roversi P, Herbert AP, Blaum BS, Tyrrell J, Jowitt TA, Clark SJ, Tarelli E, Uhrín D, et al (2007). Structural basis for complement factor H linked age-related macular degeneration. J Exp Med, 204(10), 2277-2283. Abstract.  Author URL.  Full text.

Chapters

Curnow A, Tyrrell J (2015). The mechanism of action of topical dermatological photodynamic therapy. In  (Ed) Photodynamic Therapy: Fundamentals, Applications and Health Outcomes, 59-102.  Abstract.
Pye A, Dogra Y, Tyrrell J, Winyard PG, Curnow A (2009). Photodynamic therapy with aminolevulinic acid and iron chelators: a clinical example of redox signaling. In Jacob C, Winyard PG, Wiley-VCH (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: , 351-372.

Conferences

Yaghootkar H, Ji Y, Tyrrell J, Jones SE, Beaumont R, Tuke MA, Ruth KS, Freathy RM, Wood AR, Murray A, et al (2017). Identification of alleles associated with higher body fat percentage but lower risk of type 2 diabetes.  Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study.  Author URL.  Full text.
Yaghootkar H, Lotta L, Tyrrell J, Smit R, Jones S, Donnelly L, Beaumont R, Campbell A, Tuke M, Hayward C, et al (2016). Genetic Evidence for a Link between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.  Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont R, Ruth K, Tuke M, Yaghootkar H, Teder-Laving M, Hayward C, Roenneberg T, et al (2016). Genetic Studies of Sleep and Morningness and Their Relationship with Obesity and Type 2 Diabetes.  Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames R, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). High Risk Obesogenic Environments Accentuate Genetic Susceptibility to Obesity.  Author URL.
Tyrrell J, Jones SE, Beaumont R, Astley C, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, et al (2016). Higher BMI Leads to Lower Socioeconomic Status: a Mendelian Randomisation Study in the UK Biobank.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies.  Author URL.
Osborne NJ, Amos B, Tyrrell J (2015). Adult Drug and Food Allergy in the UK Biobank Cohort Study.  Author URL.
Shiue I, Boyle RJ, Tyrrell J, Ukoumunne O, Osborne NJ (2013). Abnormal liver function is associated with food sensitisation: NHANES, 20052006.  Author URL.  Full text.
Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM (2013). Paternal Diabetes is Associated with Lower Birth Weight in the UK Biobank Study of 500,000 Individuals.  Author URL.
Tyrrell J, Campbell S, Curnow A (2009). The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT. Photodynamic Therapy - Back to the Future.  Abstract.
Tyrrell J, Shore A, Curnow A (2008). Monitoring clinical dermatological photodynamic therapy: validation of a noninvasive fluorescence imaging system.  Author URL.
Prosser B, Johnson S, Roversi P, Herbert A, Blaum BS, Uhrin D, Tyrrell J, Clark S, Tarelli E, Barlow P, et al (2007). Towards a structural basis for complement factor H linked age-related macular degeneration.  Author URL.

Publications by year


In Press

Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (In Press). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract.  Author URL.  Full text.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (In Press). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.  Full text.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (In Press). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics Full text.
Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (In Press). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract.  Author URL.  Full text.
Schmidt W, Sarran C, Ronan N, Barrett G, Whinney DJ, Fleming LE, Osborne NJ, Tyrrell J (In Press). The Weather and Ménière's Disease: a Longitudinal Analysis in the UK. Otol Neurotol, 38(2), 225-233. Abstract.  Author URL.  Full text.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (In Press). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.  Full text.

2018

Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract.  Author URL.  Full text.
Yeo NL, White MP, Ronan N, Whinney DJ, Curnow A, Tyrrell J (2018). Stress and Unusual Events Exacerbate Symptoms in Menière's Disease: a Longitudinal Study. Otol Neurotol, 39(1), 73-81. Abstract.  Author URL.  Full text.

2017

Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract.  Author URL.  Full text.
Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X, Czajkowski J, Hadley D, et al (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun, 8 Abstract.  Author URL.  Full text.
Yaghootkar H, Ji Y, Tyrrell J, Jones SE, Beaumont R, Tuke MA, Ruth KS, Freathy RM, Wood AR, Murray A, et al (2017). Identification of alleles associated with higher body fat percentage but lower risk of type 2 diabetes.  Author URL.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract.  Author URL.  Full text.

2016

Bell SL, Tyrrell J, Phoenix C (2016). A day in the life of a Ménière’s patient: understanding the lived experiences and mental health impacts of Ménière’s disease. Sociology of Health and Illness Full text.
Frayling TM, Tyrrell J (2016). Authors' reply to Toth. BMJ, 353 Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study.  Author URL.  Full text.
Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NMG, et al (2016). Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA, 315(11), 1129-1129. Full text.
Yaghootkar H, Lotta L, Tyrrell J, Smit R, Jones S, Donnelly L, Beaumont R, Campbell A, Tuke M, Hayward C, et al (2016). Genetic Evidence for a Link between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease.  Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont R, Ruth K, Tuke M, Yaghootkar H, Teder-Laving M, Hayward C, Roenneberg T, et al (2016). Genetic Studies of Sleep and Morningness and Their Relationship with Obesity and Type 2 Diabetes.  Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.  Full text.
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.  Full text.
Frayling TM, Tyrrell J (2016). HEIGHT, BODY MASS INDEX, AND SOCIOECONOMIC STATUS Conclusions of study on height, body mass index, and socioeconomic status have an uncertain basis Reply. BMJ-BRITISH MEDICAL JOURNAL, 353 Author URL.  Full text.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames R, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). High Risk Obesogenic Environments Accentuate Genetic Susceptibility to Obesity.  Author URL.
Tyrrell J, Jones SE, Beaumont R, Astley C, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, et al (2016). Higher BMI Leads to Lower Socioeconomic Status: a Mendelian Randomisation Study in the UK Biobank.  Author URL.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Bell SL, Tyrrell J, Phoenix C (2016). Ménière’s disease and biographical disruption: where family transitions collide. Social Science and Medicine Full text.
Tyrrell J, Schmidt W, Williams DH, Redshaw CH (2016). Physical activity in ankylosing spondylitis: evaluation and analysis of an eHealth tool. Journal of Innovation in Health Informatics Full text.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies.  Author URL.
Tyrrell J, Whinney DJ, Taylor T (2016). The Cost of Ménière's Disease: a Novel Multisource Approach. Ear Hear, 37(3), e202-e209. Abstract.  Author URL.

2015

Osborne NJ, Amos B, Tyrrell J (2015). Adult Drug and Food Allergy in the UK Biobank Cohort Study.  Author URL.
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Ménière's: Cross-Sectional Analysis in the UK Biobank. Ear Hear, 36(3), e122-e128. Abstract.  Author URL.
Tyrrell JS, Taylor MS, Whinney D, Osborne NJ (2015). Associations of Leg Length, Trunk Length, and Total Adult Height with Menière's: Cross-Sectional Analysis in the UK Biobank. Ear and Hearing, 36(3), e122-e128. Abstract.
Morris RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M, Campbell A, Marioni R, Kumari M, Korhonen T, et al (2015). Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. BMJ Open, 5(8). Abstract.  Author URL.
Tyrrell J, White M, Barrett G, Ronan N, Phoenix C, Whinney D, Osborne N (2015). Mental Health and Subjective Wellbeing of individuals with Ménière’s: Cross Sectional Analysis in the UK Biobank. Otology & Neurotology
Kendall M, Hodges NJ, Whitwell H, Tyrrell J, Cangul H (2015). Nanoparticle growth and surface chemistry changes in cell-conditioned culture medium. Philos Trans R Soc Lond B Biol Sci, 370(1661). Abstract.  Author URL.
Curnow A, Tyrrell J (2015). The mechanism of action of topical dermatological photodynamic therapy. In  (Ed) Photodynamic Therapy: Fundamentals, Applications and Health Outcomes, 59-102.  Abstract.
Sharpe RA, Thornton CR, Tyrell J, Nikolaou V, Osborne NJ (2015). Variable risk of atopic disease due to indoor fungal exposure in NHANES 2005-2006. Clinical and Experimental Allergy, 45(10), 1566-1578.

2014

Freathy RM, Tyrrell J, Bradfield JP, Cavadino A, Feenstra B, Hayes MG, Hottenga JJ, Huikari V, Kreiner-Moller E, Metrustry S, et al (2014). Genetic analyses identify positive causal effects of maternal fasting glucose, Type 2 diabetes and vitamin D levels, and an inverse causal effect of maternal blood pressure, on offspring birth weight. DIABETIC MEDICINE, 31, 18-18. Author URL.
Tyrrell JS, Whinney DJD, Ukoumunne OC, Fleming LE, Osborne NJ (2014). Prevalence, associated factors, and comorbid conditions for Ménière's disease. Ear Hear, 35(4), e162-e169. Abstract.  Author URL.
Taylor AE, Morris RW, Fluharty ME, Bjorngaard JH, Åsvold BO, Gabrielsen ME, Campbell A, Marioni R, Kumari M, Hällfors J, et al (2014). Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genet, 10(12). Abstract.  Author URL.

2013

Shiue I, Boyle RJ, Tyrrell J, Ukoumunne O, Osborne NJ (2013). Abnormal liver function is associated with food sensitisation: NHANES, 20052006.  Author URL.  Full text.
Depledge MH, Tyrrell J, Fleming LE, Holgate ST (2013). Are marine environmental pollutants influencing global patterns of human disease?. Mar Environ Res, 83, 93-95. Abstract.  Author URL.
Depledge MH, Tyrrell J, Fleming LE, Holgate ST (2013). Are marine environmental pollutants influencing global patterns of human disease?. Marine Environmental Research, 83, 93-95. Abstract.
Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ (2013). Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int, 59, 328-335. Abstract.  Author URL.
Tyrrell J, Galloway TS, Abo-Zaid G, Melzer D, Depledge MH, Osborne NJ (2013). High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010. PLoS One, 8(11). Abstract.  Author URL.  Full text.
Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM (2013). Parental diabetes and birthweight in 236 030 individuals in the UK biobank study. Int J Epidemiol, 42(6), 1714-1723. Abstract.  Author URL.  Full text.
Tyrrell JS, Yaghootkar H, Freathy RM, Hattersley AT, Frayling TM (2013). Paternal Diabetes is Associated with Lower Birth Weight in the UK Biobank Study of 500,000 Individuals.  Author URL.

2012

Tyrrell J, Huikari V, Christie JT, Cavadino A, Bakker R, Brion M-JA, Geller F, Paternoster L, Myhre R, Potter C, et al (2012). Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet, 21(24), 5344-5358. Abstract.  Author URL.  Full text.

2011

Tyrrell JS, Morton C, Campbell SM, Curnow A (2011). Comparison of protoporphyrin IX accumulation and destruction during methylaminolevulinate photodynamic therapy of skin tumours located at acral and nonacral sites. Br J Dermatol, 164(6), 1362-1368. Abstract.  Author URL.  Full text.
Tyrrell J, Campbell SM, Curnow A (2011). Monitoring the accumulation and dissipation of the photosensitizer protoporphyrin IX during standard dermatological methyl-aminolevulinate photodynamic therapy utilizing non-invasive fluorescence imaging and quantification. Photodiagnosis Photodyn Ther, 8(1), 30-38. Abstract.  Author URL.  Full text.
Tyrrell J, Thorn C, Shore A, Campbell S, Curnow A (2011). Oxygen saturation and perfusion changes during dermatological methyl-aminolevulinate photodynamic therapy. British Journal of Dermatology Full text.
Tyrrell J, Campbell SM, Curnow A (2011). The effect of air cooling pain relief on protoporphyrin IX photobleaching and clinical efficacy during dermatological photodynamic therapy. J Photochem Photobiol B, 103(1), 1-7. Abstract.  Author URL.

2010

Campbell SM, Tyrrell J, Marshall R, Curnow A (2010). Effect of MAL-photodynamic therapy on hypertrophic scarring. Photodiagnosis Photodyn Ther, 7(3), 183-188. Abstract.  Author URL.
Tyrrell J, Campbell S, Curnow A (2010). Protoporphyrin IX photobleaching during the light irradiation phase of standard dermatological methyl-aminolevulinate photodynamic therapy. Photodiagnosis Photodyn Ther, 7(4), 232-238. Abstract.  Author URL.
Tyrrell JS, Campbell SM, Curnow A (2010). The relationship between protoporphyrin IX photobleaching during real-time dermatological methyl-aminolevulinate photodynamic therapy (MAL-PDT) and subsequent clinical outcome. Lasers Surg Med, 42(7), 613-619. Abstract.  Author URL.  Full text.
Tyrrell J, Campbell S, Curnow A (2010). Validation of a non-invasive fluorescence imaging system to monitor dermatological PDT. Photodiagnosis Photodyn Ther, 7(2), 86-97. Abstract.  Author URL.  Full text.

2009

Pye A, Dogra Y, Tyrrell J, Winyard PG, Curnow A (2009). Photodynamic therapy with aminolevulinic acid and iron chelators: a clinical example of redox signaling. In Jacob C, Winyard PG, Wiley-VCH (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: , 351-372.
Tyrrell J, Campbell S, Curnow A (2009). The utilization of a non-invasive fluorescence imaging system to follow clinical dermatological MAL-PDT. Photodynamic Therapy - Back to the Future.  Abstract.

2008

Tyrrell J, Shore A, Curnow A (2008). Monitoring clinical dermatological photodynamic therapy: validation of a noninvasive fluorescence imaging system.  Author URL.

2007

Prosser BE, Johnson S, Roversi P, Herbert AP, Blaum BS, Tyrrell J, Jowitt TA, Clark SJ, Tarelli E, Uhrín D, et al (2007). Structural basis for complement factor H linked age-related macular degeneration. J Exp Med, 204(10), 2277-2283. Abstract.  Author URL.  Full text.
Prosser B, Johnson S, Roversi P, Herbert A, Blaum BS, Uhrin D, Tyrrell J, Clark S, Tarelli E, Barlow P, et al (2007). Towards a structural basis for complement factor H linked age-related macular degeneration.  Author URL.

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