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Dr Jacqueline Whatmore

Dr Jacqueline Whatmore

Senior Lecturer in Cell and Molecular Biology and Clinical Microvascular Research

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Jacqueline Whatmore graduated with a degree in Biology from University of Manchester and was awarded her PhD in Cell Biology from Aston.  Following postdoctoral positions at University College London, Dr Whatmore moved to the University of Exeter to specialise in endothelial cell biology.

Dr Whatmore is currently a Senior Lecturer and head of the Endothelial Cell Biology Group. Her research focuses on the molecular basis of vascular/endothelial changes in pathological conditions such as diabetes and cancer metastasis and is funded by the Medical Research Council, Diabetes UK, the British Heart Foundation, and FORCE Cancer Charity.

Dr Whatmore is actively involved in Microcirculation research worldwide and is the Honorary Treasurer of the British Microcirculation Society.

Research

Key publications | Publications by category | Publications by year

Key publications


Thorn CE (In Press). Microstructure and mechanics of human resistance arteries. American Journal of Physiology - Heart and Circulatory Physiology Full text.
Gerő D, Torregrossa R, Perry A, Waters A, Le-Trionnaire S, Whatmore JL, Wood M, Whiteman M (2016). The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res, 113(Pt A), 186-198. Abstract.  Author URL.  Full text.
Rai S, Nejadhamzeeigilani Z, Gutowski NJ, Whatmore JL (2015). Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium. J Exp Clin Cancer Res, 34 Abstract.  Author URL.  Full text.
Winiarski BK, Cope N, Alexander M, Pilling LC, Warren S, Acheson N, Gutowski NJ, Whatmore JL (2014). Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma. Transl Oncol, 7(2), 267-276.e4. Abstract.  Author URL.  Full text.
Blanch EA, Maskell L, Colucci MA, Whatmore JLA, Moody CJ (2009). Sythesis of potential prodrug systems for reductive activation. Prodrugs for anti-angiogenic isoflavones and VEGF receptor tyrosine kinase inhibitory oxindoles. Tetrahedron, 65, 4894-4903.
McHarg S, Shore AC, Whatmore JL (2008). Heterogeneity of phospholipase D activation by angiotensin II, lysophosphatidylcholine, and insulin in human endothelial cells. Endothelium, 15(4), 213-218. Abstract.  Author URL.

Publications by category


Journal articles

Thorn CE (In Press). Microstructure and mechanics of human resistance arteries. American Journal of Physiology - Heart and Circulatory Physiology Full text.
Freeman LAR, Gooding KM, Whatmore JL (2016). Incretin-based antidiabetic therapy induces microvascular endothelial cell proliferation, via AKT and PRAS40 phosphorylation. DIABETIC MEDICINE, 33, 87-87. Author URL.
Corcoran J, Petrov P, Whatmore J, Winlove P, Morgan NG (2016). Molecular analysis of the uptake and disposition of long chain fatty acids (LCFA) in beta cells. DIABETIC MEDICINE, 33, 81-81. Author URL.
Gerő D, Torregrossa R, Perry A, Waters A, Le-Trionnaire S, Whatmore JL, Wood M, Whiteman M (2016). The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res, 113(Pt A), 186-198. Abstract.  Author URL.  Full text.
Welters HJ, Bowen A, Whatmore J, Kos K, Richardson S (2016). Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and Biophysical Research Communications Full text.
Rai S, Nejadhamzeeigilani Z, Gutowski NJ, Whatmore JL (2015). Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium. J Exp Clin Cancer Res, 34 Abstract.  Author URL.  Full text.
Freeman LAR, Gooding KM, Whatmore JL (2015). Proliferation effects of liraglutide on human microvascular endothelial cells. DIABETIC MEDICINE, 32, 100-100. Author URL.
Pranjol MZI, Gutowski N, Hannemann M, Whatmore J (2015). The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer. Biomolecules, 5(4), 3260-3279. Abstract.  Author URL.  Full text.
Winiarski BK, Cope N, Alexander M, Pilling LC, Warren S, Acheson N, Gutowski NJ, Whatmore JL (2014). Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma. Transl Oncol, 7(2), 267-276.e4. Abstract.  Author URL.  Full text.
Lo Faro ML, Fox B, Whatmore JL, Winyard PG, Whiteman M (2014). Hydrogen sulfide and nitric oxide interactions in inflammation. Nitric Oxide, 41, 38-47. Abstract.  Author URL.
Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M (2014). The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39). MedChemComm, 5(6), 728-736. Abstract.  Full text.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.
Winiarski BK, Wolanska KI, Rai S, Ahmed T, Acheson N, Gutowski NJ, Whatmore JL (2013). Epithelial ovarian cancer-induced angiogenic phenotype of human omental microvascular endothelial cells may occur independently of VEGF signaling. Translational Oncology, 6(6), 703-714. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Bowen AR, Whatmore J, Kos K, Welters HJ (2013). Role of non-canonical Wnt signalling in pancreatic beta cells. DIABETIC MEDICINE, 30, 17-17. Author URL.
Turner PA, Samiullah, Whatmore JL, Shipman M (2013). Stereocontrolled synthesis of a d-amicetose functionalised tetrahydroxanthone related to kigamicin A. Tetrahedron Letters, 54(48), 6538-6540. Abstract.
Turner PA, Samiullah, Whatmore JL, Shipman M (2013). Stereocontrolled synthesis of a d-amicetose functionalised tetrahydroxanthone related to kigamicin A. Tetrahedron Letters
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166. Author URL.
Winiarski BK, Acheson N, Gutowski NJ, McHarg S, Whatmore JL (2011). An improved and reliable method for isolation of microvascular endothelial cells from human omentum. Microcirculation, 18(8), 635-645. Abstract.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.
Whiteman M, Le Trionnaire S, Chopra M, Fox B, Whatmore J (2011). Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clin Sci (Lond), 121(11), 459-488. Abstract.  Author URL.
Whiteman M, Strain WD, Whatmore JL, Gooding K, Ball C, Mawson D, Tooke JE, Shore AC (2011). Sex differences in the association between plasma levels of the novel vasodilatory gas hydrogen sulfide, adiposity and micro- and macrovascular function in vivo. JOURNAL OF HUMAN HYPERTENSION, 25(10), 651-651. Author URL.
Turner PA, Griffin EM, Whatmore JL, Shipman M (2011). Tetrahydroxanthones by sequential Pd-catalyzed C-O and C-C bond construction and use in the identification of the "antiausterity" pharmacophore of the kigamicins. Org Lett, 13(5), 1056-1059. Abstract.  Author URL.
Whiteman M, Gooding KM, Whatmore JL, Skinner K, Ball C, Tooke JE, Shore AC (2010). 026 Plasma levels of the novel vasodilatory gas hydrogen sulphide are associated with adiposity. Heart, 96(4), e8-e8.
Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC (2010). Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia, 53(8), 1722-1726. Abstract.  Author URL.
Wolanska KI, Tarr JM, Whatmore JL, Chibber R (2010). HYPERGLYCEMIA ALTERS RETINAL ENDOTHELIAL CELL GLYCOCALYX: POTENTIAL ROLE OF HEPARANASE 1. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 20(3), 640-640. Author URL.
Holley JE, Newcombe J, Whatmore JL, Gutowski NJ (2010). Increased blood vessel density and endothelial cell proliferation in multiple sclerosis cerebral white matter. Neurosci Lett, 470(1), 65-70. Abstract.  Author URL.
Blanch EA, Maskell L, Colucci MA, Whatmore JLA, Moody CJ (2009). Sythesis of potential prodrug systems for reductive activation. Prodrugs for anti-angiogenic isoflavones and VEGF receptor tyrosine kinase inhibitory oxindoles. Tetrahedron, 65, 4894-4903.
McHarg S, Shore AC, Whatmore JL (2008). Heterogeneity of phospholipase D activation by angiotensin II, lysophosphatidylcholine, and insulin in human endothelial cells. Endothelium, 15(4), 213-218. Abstract.  Author URL.
Maskell L, Blanche EA, Colucci MA, Whatmore JL, Moody CJ (2007). Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles. Bioorg Med Chem Lett, 17(6), 1575-1578. Abstract.  Author URL.
Holley J, Eggleton P, Whatmore J, Gutowski N (2007). Temporal changes in endothelial cell activation occur in MS lesion formation. NEURON GLIA BIOLOGY, 2, S35-S35. Author URL.
JWhatmore, Konopatskaya O, Shore A, Tooke J (2005). A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. Diabetologia, 48(3), 595-604.
Konopatskaya O, Shore AC, Tooke JE, Whatmore JL (2005). A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. Diabetologia, 48(3), 595-604. Abstract.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2005). Blood vessel density is increased in chronic MS lesions: Relationship to scarring. EUROPEAN JOURNAL OF NEUROLOGY, 12, 129-129. Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Human lung tumour cells induce changes in human astrocyte phenotype in vitro: Relevance to metastasis evolution. EUROPEAN JOURNAL OF NEUROLOGY, 12, 143-143. Author URL.
JWhatmore, Gutowski N, Gveric J, Holley J (2005). Tenascin C induces a quiescent phenotype in cultured adult human astrocytes. Glia, 52(1), 53-58.
Holley JE, Gveric D, Whatmore JL, Gutowski NJ (2005). Tenascin C induces a quiescent phenotype in cultured adult human astrocytes. Glia, 52(1), 53-58. Abstract.  Author URL.
Barker AL, Konopatskaya O, Neal CR, Macpherson JV, Whatmore JL, Winlove CP, Unwin PR, Shore AC (2004). Observation and characterisation of the glycocalyx of viable human endothelial cells using confocal laser scanning microscopy. Physical Chemistry Chemical Physics, 6(5), 1006-1011. Abstract.
Davies MW, Maskell L, Shipman M, Slawin AMZ, Vidot SME, Whatmore JL (2004). Studies toward the synthesis of luminacin D: Assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity. Organic Letters, 6(22), 3909-3912. Abstract.
JWhatmore, Konopatskaya P, Shore A, Tooke J (2003). Insulin and lysophosphatidylcholine synergistically stimulate NO-dependent cGMP production in human endothelial cells. Diabetic Medicine, 20(10), 838-845.
Konopatskaya O, Whatmore JL, Tooke JE, Shore AC (2003). Insulin and lysophosphatidylcholine synergistically stimulate NO-dependent cGMP production in human endothelial cells. Diabet Med, 20(10), 838-845. Abstract.  Author URL.
Whatmore JL, Swann E, Barraja P, Newsome JJ, Bunderson M, Beall HD, Tooke JE, Moody CJ (2002). Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Angiogenesis, 5(1-2), 45-51. Abstract.  Author URL.
Whatmore J, Wiedemann C, Somerharju P, Swigart P, Cockcroft S (1999). Resynthesis of phosphatidylinositol in permeabilized neutrophils following phospholipase Cbeta activation: transport of the intermediate, phosphatidic acid, from the plasma membrane to the endoplasmic reticulum for phosphatidylinositol resynthesis is not dependent on soluble lipid carriers or vesicular transport. Biochem J, 341 ( Pt 2), 435-444. Abstract.  Author URL.
Fensome A, Whatmore J, Morgan C, Jones D, Cockcroft S (1998). ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils. J Biol Chem, 273(21), 13157-13164. Abstract.  Author URL.
Morgan CP, Sengelov H, Whatmore J, Borregaard N, Cockcroft S (1997). ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils. Biochem J, 325 ( Pt 3), 581-585. Abstract.  Author URL.
Kular G, Loubtchenkov M, Swigart P, Whatmore J, Ball A, Cockcroft S, Wetzker R (1997). Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils. Biochem J, 325 ( Pt 2), 299-301. Abstract.  Author URL.
Whatmore J, Morgan CP, Cunningham E, Collison KS, Willison KR, Cockcroft S (1996). ADP-ribosylation factor 1-regulated phospholipase D activity is localized at the plasma membrane and intracellular organelles in HL60 cells. Biochem J, 320 ( Pt 3), 785-794. Abstract.  Author URL.
Whatmore J, Cronin P, Cockcroft S (1994). ARF1-regulated phospholipase D in human neutrophils is enhanced by PMA and MgATP. FEBS Lett, 352(2), 113-117. Abstract.  Author URL.
Whatmore JLA, Allan D (1994). Phospholipid asymmetry in plasma membrane vesicles derived from BHK cells. Biochimica and Biophysica Acta, 1192, 88-94.
Kallen KJ, Allan D, Whatmore J, Quinn P (1994). Synthesis of surface sphingomyelin in the plasma membrane recycling pathway of BHK cells. Biochim Biophys Acta, 1191(1), 52-58. Abstract.  Author URL.
THOMAS G, FENSOME A, WHATMORE J, GENY B, COCKCROFT S (1994). THE REGULATION OP PHOSPHOLIPASE-D BY ARFS. JOURNAL OF NEUROCHEMISTRY, 63, S29-S29. Author URL.
Whatmore J, Quinn P, Allan D (1993). Plasma membrane vesicles from BHK and HL60 cells treated with merocyanine 540 and iodoacetamide. Biochim Biophys Acta, 1152(2), 300-306. Abstract.  Author URL.
Whatmore JLA, Tang EKY, Hickman JA (1992). Cytoskeletal proteolysis during calcium-induced morphological transitions of human erythrocytes. Experimental Cell Research(200), 316-325.

Chapters

Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.

Conferences

Kahve AMS, Richardson SJ, Petrov PG, Whatmore JL, Winlove CP, Morgan NG (2017). Investigating beta cell and endothelial cell responses to fatty acids.  Author URL.
Gutowski N, Rai S, Whatmore J (2015). LUNG CANCER BRAIN METASTASES: FACTORS ENHANCING TUMOUR CELL ADHESION.  Author URL.
Whatmore J, Rai S, Gutowski N (2015). LUNG TUMOUR CELL SECRETED VEGF AND TNF-? DEGRADE GLYCOCALYX AND INCREASE SURFACE E-SELECTIN ON HUMAN CEREBRAL ENDOTHELIAL CELLS.  Author URL.
Gutowski NJ, Rai S, Whatmore JL (2014). Mechanisms of lung tumour cell adhesion to human brain microvascular endothelial cells (HBMECs) during cerebral metastasis formation.  Author URL.
Gutowski NJ, Rai S, Whatmore JL (2014). Mechanisms of lung tumour cell adhesion to human brain microvascular endothelial cells (HBMECs) during cerebral metastasis formation.  Author URL.
Lo Faro ML, Whatmore J, More J, Whiteman M, Winyard PG (2013). Is hydrogen sulfide involved in mediating functional effects of dietary nitrate ingestion in humans?.  Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Wood ME, Whiteman M (2013). Mitochondria-targeted hydrogen sulfide donors: a novel twist to an old "tail"?.  Author URL.
Whiteman M, Perry A, Le Trionnaire S, Whatmore JL, Ahmed T, Fox B, Kerr P, Haigh R, Winyard PG, Wood ME, et al (2013). Modulation of inflammatory and vascular signalling by novel slow release and mitochondria-targeted H2S donors.  Author URL.
Whatmore JL, Wolanska KI, Perry A, Wood ME, Whiteman M (2013). Slow release hydrogen sulfide (H2S) donors prevent hyperglycaemia-induced glycocalyx loss in retinal mirovascular endothelial cells.  Author URL.
Wolanska K, Perry A, Wood ME, Chibber R, Whatmore J, Whiteman M (2012). Hydrogen sulfide - a novel guardian of the endothelial glycocalyx?.  Author URL.
Gutowski N, Rai S, Whatmore JL (2012). LUNG TUMOUR SECRETED VEGF AND TNF-alpha INDUCE EXPRESSION OF ADHESION MOLECULES ON CEREBRAL ENDOTHELIAL CELLS.  Author URL.
Gutowski NJ, Rai S, Whatmore JL (2012). Lung tumour cells secrete factors that enhance brain endothelial cell adhesion expression.  Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Winyard PG, Wood ME, Whiteman M (2012). Mitochondria-Targeted Slow Release Hydrogen Donors: a Novel Link to an Old 'tail'?.  Author URL.
Lo Faro ML, Whatmore J, More J, Wood ME, Whiteman M, Winyard PG (2012). Mutual regulation of (NO)-N-center dot/H2S bioavailability and cell signalling in the cardiovascular system.  Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Matthew W (2012). Slow release H2S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targeting.  Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2012). Slow release H2S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targetting.  Author URL.
Turner PA, Griffin EM, Whatmore JL, Shipman M (2011). Biologically active tetrahydroxanthones by sequential Pd-catalyzed C-O and C-C bond construction.  Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulfide (H2 S) and novel slow release H2S donors protect human endothelial cells from oxidative stress-induced cell death.  Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulphide (H2S) and novel slow release H2S donors protect human microvascular endothelial cells from oxidative stress-induced cell death.  Author URL.
Whiteman M, Chopra M, Wood ME, Whatmore JL (2010). ENDOGENOUS HYDROGEN SULFIDE (H2S) AND NOVEL SLOW RELEASING H2S DONOR COMPOUNDS INHIBIT ENDOTHELIAL DYSFUNCTION INDUCED BY TNF- alpha, OXIDATIVE AND NITROSATIVE STRESS.  Author URL.
Whiteman M, Wood ME, Whatmore JL (2010). Novel Slow Releasing Hydrogen Sulfide (H2S) Donor Compounds Inhibit Endothelial Dysfunction Induced by TNF-alpha, Oxidative and Nitrosative Stress.  Author URL.
Gutowski NJ, Nejadhamzeeigilani Z, Eggleton P, Whatmore JL (2009). Factors released from lung tumour cells alter adhesion molecule expression and increase activation of human cerebral endothelial cells.  Author URL.
Whiteman M, Whatmore JL, Gooding KM, Ball CL, Mawson D, Skinner K, Tooke JE, Shore A (2009). PLASMA LEVELS OF THE NOVEL VASODILATORY GAS HYDROGEN SULFIDE (H2S) ARE ASSOCIATED WITH ADIPOSITY.  Author URL.
Whiteman M, Gooding K, Whatmore J, Ball CI, Mawson D, Skinner K, Shore AC (2009). Plasma Hydrogen Sulfide (H2S) and Correlations with Physical, Clinical and Vascular indices of Obesity, Metabolic Syndrome and type II Diabetes.  Author URL.
Whiteman M, Whatmore JL, Skinner K, Ball C, Gooding KM, Shore AC (2009). Plasma hydrogen sulphide: correlations with clinical indices of micro- and macrovascular function, obesity, metabolic syndrome and type II diabetes.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2008). Changes in endothelial cell activation occur in multiple sclerosis lesion formation.  Author URL.
Busch R, Watson P, Whatmore J, Hall FC (2008). Towards blood-based biomarkers for endothelial dysfunction in systemic autoimmune disease.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2007). Alteration in blood vessel density in multiple sclerosis lesions implies a role in brain scarring.  Author URL.
McHarg S, Shore AC, Whatmore JL (2006). Insulin induced phospholipase D activation in human endothelial cells.  Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Tooke JE, Shore AC (2006). Microvascular function is altered by polymorphisms in the promoter region of the aldose reductase gene in healthy subjects.  Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Jarvis D, Tooke JE, Shore AC (2006). The impact of polymorphisms in the promoter region of the aldose reductase gene on microvascular function in healthy subjects.  Author URL.
McHarg S, Whatmore J, Shore A (2005). Activation of phospholipase D by angiotensin II in HUVECS and HMVECS.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2005). Increased blood vessel density in chronic multiple sclerosis lesions.  Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Lung tumour cells induce changes in astrocyte phenotype in vitro: relevance to brain metastasis evolution.  Author URL.
Gutowski NJ, Holley JE, Whatmore JL (2003). Brain scarring: Effects of extracellular matrix on astrocyte phenotype.  Author URL.
Konopatskaya O, Whatmore JL, Shore AC, Tooke JE (2001). Modulation of nitric oxide production by lysophosphatidylcholine in human endothelial cells.  Author URL.

Publications by year


In Press

Thorn CE (In Press). Microstructure and mechanics of human resistance arteries. American Journal of Physiology - Heart and Circulatory Physiology Full text.

2017

Kahve AMS, Richardson SJ, Petrov PG, Whatmore JL, Winlove CP, Morgan NG (2017). Investigating beta cell and endothelial cell responses to fatty acids.  Author URL.

2016

Freeman LAR, Gooding KM, Whatmore JL (2016). Incretin-based antidiabetic therapy induces microvascular endothelial cell proliferation, via AKT and PRAS40 phosphorylation. DIABETIC MEDICINE, 33, 87-87. Author URL.
Corcoran J, Petrov P, Whatmore J, Winlove P, Morgan NG (2016). Molecular analysis of the uptake and disposition of long chain fatty acids (LCFA) in beta cells. DIABETIC MEDICINE, 33, 81-81. Author URL.
Gerő D, Torregrossa R, Perry A, Waters A, Le-Trionnaire S, Whatmore JL, Wood M, Whiteman M (2016). The novel mitochondria-targeted hydrogen sulfide (H2S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro. Pharmacol Res, 113(Pt A), 186-198. Abstract.  Author URL.  Full text.
Welters HJ, Bowen A, Whatmore J, Kos K, Richardson S (2016). Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and Biophysical Research Communications Full text.

2015

Gutowski N, Rai S, Whatmore J (2015). LUNG CANCER BRAIN METASTASES: FACTORS ENHANCING TUMOUR CELL ADHESION.  Author URL.
Whatmore J, Rai S, Gutowski N (2015). LUNG TUMOUR CELL SECRETED VEGF AND TNF-? DEGRADE GLYCOCALYX AND INCREASE SURFACE E-SELECTIN ON HUMAN CEREBRAL ENDOTHELIAL CELLS.  Author URL.
Rai S, Nejadhamzeeigilani Z, Gutowski NJ, Whatmore JL (2015). Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium. J Exp Clin Cancer Res, 34 Abstract.  Author URL.  Full text.
Freeman LAR, Gooding KM, Whatmore JL (2015). Proliferation effects of liraglutide on human microvascular endothelial cells. DIABETIC MEDICINE, 32, 100-100. Author URL.
Pranjol MZI, Gutowski N, Hannemann M, Whatmore J (2015). The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer. Biomolecules, 5(4), 3260-3279. Abstract.  Author URL.  Full text.

2014

Winiarski BK, Cope N, Alexander M, Pilling LC, Warren S, Acheson N, Gutowski NJ, Whatmore JL (2014). Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma. Transl Oncol, 7(2), 267-276.e4. Abstract.  Author URL.  Full text.
Lo Faro ML, Fox B, Whatmore JL, Winyard PG, Whiteman M (2014). Hydrogen sulfide and nitric oxide interactions in inflammation. Nitric Oxide, 41, 38-47. Abstract.  Author URL.
Gutowski NJ, Rai S, Whatmore JL (2014). Mechanisms of lung tumour cell adhesion to human brain microvascular endothelial cells (HBMECs) during cerebral metastasis formation.  Author URL.
Gutowski NJ, Rai S, Whatmore JL (2014). Mechanisms of lung tumour cell adhesion to human brain microvascular endothelial cells (HBMECs) during cerebral metastasis formation.  Author URL.
Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M (2014). The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39). MedChemComm, 5(6), 728-736. Abstract.  Full text.

2013

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.
Winiarski BK, Wolanska KI, Rai S, Ahmed T, Acheson N, Gutowski NJ, Whatmore JL (2013). Epithelial ovarian cancer-induced angiogenic phenotype of human omental microvascular endothelial cells may occur independently of VEGF signaling. Translational Oncology, 6(6), 703-714. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Lo Faro ML, Whatmore J, More J, Whiteman M, Winyard PG (2013). Is hydrogen sulfide involved in mediating functional effects of dietary nitrate ingestion in humans?.  Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Wood ME, Whiteman M (2013). Mitochondria-targeted hydrogen sulfide donors: a novel twist to an old "tail"?.  Author URL.
Whiteman M, Perry A, Le Trionnaire S, Whatmore JL, Ahmed T, Fox B, Kerr P, Haigh R, Winyard PG, Wood ME, et al (2013). Modulation of inflammatory and vascular signalling by novel slow release and mitochondria-targeted H2S donors.  Author URL.
Bowen AR, Whatmore J, Kos K, Welters HJ (2013). Role of non-canonical Wnt signalling in pancreatic beta cells. DIABETIC MEDICINE, 30, 17-17. Author URL.
Whatmore JL, Wolanska KI, Perry A, Wood ME, Whiteman M (2013). Slow release hydrogen sulfide (H2S) donors prevent hyperglycaemia-induced glycocalyx loss in retinal mirovascular endothelial cells.  Author URL.
Turner PA, Samiullah, Whatmore JL, Shipman M (2013). Stereocontrolled synthesis of a d-amicetose functionalised tetrahydroxanthone related to kigamicin A. Tetrahedron Letters, 54(48), 6538-6540. Abstract.
Turner PA, Samiullah, Whatmore JL, Shipman M (2013). Stereocontrolled synthesis of a d-amicetose functionalised tetrahydroxanthone related to kigamicin A. Tetrahedron Letters

2012

Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166. Author URL.
Wolanska K, Perry A, Wood ME, Chibber R, Whatmore J, Whiteman M (2012). Hydrogen sulfide - a novel guardian of the endothelial glycocalyx?.  Author URL.
Gutowski N, Rai S, Whatmore JL (2012). LUNG TUMOUR SECRETED VEGF AND TNF-alpha INDUCE EXPRESSION OF ADHESION MOLECULES ON CEREBRAL ENDOTHELIAL CELLS.  Author URL.
Gutowski NJ, Rai S, Whatmore JL (2012). Lung tumour cells secrete factors that enhance brain endothelial cell adhesion expression.  Author URL.
Le Trionnaire S, Perry A, Whatmore JL, Winyard PG, Wood ME, Whiteman M (2012). Mitochondria-Targeted Slow Release Hydrogen Donors: a Novel Link to an Old 'tail'?.  Author URL.
Lo Faro ML, Whatmore J, More J, Wood ME, Whiteman M, Winyard PG (2012). Mutual regulation of (NO)-N-center dot/H2S bioavailability and cell signalling in the cardiovascular system.  Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Matthew W (2012). Slow release H2S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targeting.  Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2012). Slow release H2S donors protect human microvascular endothelial cells from oxidative stress induced cell death: Markedly increased potency by mitochondria-targetting.  Author URL.

2011

Winiarski BK, Acheson N, Gutowski NJ, McHarg S, Whatmore JL (2011). An improved and reliable method for isolation of microvascular endothelial cells from human omentum. Microcirculation, 18(8), 635-645. Abstract.  Author URL.
Turner PA, Griffin EM, Whatmore JL, Shipman M (2011). Biologically active tetrahydroxanthones by sequential Pd-catalyzed C-O and C-C bond construction.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.
Whiteman M, Le Trionnaire S, Chopra M, Fox B, Whatmore J (2011). Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools. Clin Sci (Lond), 121(11), 459-488. Abstract.  Author URL.
Le Trionnaire S, Whatmore JL, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulfide (H2 S) and novel slow release H2S donors protect human endothelial cells from oxidative stress-induced cell death.  Author URL.
Le Trionnaire S, Whatmore J, Perry A, Wood ME, Whiteman M (2011). Endogenous hydrogen sulphide (H2S) and novel slow release H2S donors protect human microvascular endothelial cells from oxidative stress-induced cell death.  Author URL.
Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.
Whiteman M, Strain WD, Whatmore JL, Gooding K, Ball C, Mawson D, Tooke JE, Shore AC (2011). Sex differences in the association between plasma levels of the novel vasodilatory gas hydrogen sulfide, adiposity and micro- and macrovascular function in vivo. JOURNAL OF HUMAN HYPERTENSION, 25(10), 651-651. Author URL.
Turner PA, Griffin EM, Whatmore JL, Shipman M (2011). Tetrahydroxanthones by sequential Pd-catalyzed C-O and C-C bond construction and use in the identification of the "antiausterity" pharmacophore of the kigamicins. Org Lett, 13(5), 1056-1059. Abstract.  Author URL.

2010

Whiteman M, Gooding KM, Whatmore JL, Skinner K, Ball C, Tooke JE, Shore AC (2010). 026 Plasma levels of the novel vasodilatory gas hydrogen sulphide are associated with adiposity. Heart, 96(4), e8-e8.
Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC (2010). Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia, 53(8), 1722-1726. Abstract.  Author URL.
Whiteman M, Chopra M, Wood ME, Whatmore JL (2010). ENDOGENOUS HYDROGEN SULFIDE (H2S) AND NOVEL SLOW RELEASING H2S DONOR COMPOUNDS INHIBIT ENDOTHELIAL DYSFUNCTION INDUCED BY TNF- alpha, OXIDATIVE AND NITROSATIVE STRESS.  Author URL.
Wolanska KI, Tarr JM, Whatmore JL, Chibber R (2010). HYPERGLYCEMIA ALTERS RETINAL ENDOTHELIAL CELL GLYCOCALYX: POTENTIAL ROLE OF HEPARANASE 1. EUROPEAN JOURNAL OF OPHTHALMOLOGY, 20(3), 640-640. Author URL.
Holley JE, Newcombe J, Whatmore JL, Gutowski NJ (2010). Increased blood vessel density and endothelial cell proliferation in multiple sclerosis cerebral white matter. Neurosci Lett, 470(1), 65-70. Abstract.  Author URL.
Whiteman M, Wood ME, Whatmore JL (2010). Novel Slow Releasing Hydrogen Sulfide (H2S) Donor Compounds Inhibit Endothelial Dysfunction Induced by TNF-alpha, Oxidative and Nitrosative Stress.  Author URL.

2009

Gutowski NJ, Nejadhamzeeigilani Z, Eggleton P, Whatmore JL (2009). Factors released from lung tumour cells alter adhesion molecule expression and increase activation of human cerebral endothelial cells.  Author URL.
Whiteman M, Whatmore JL, Gooding KM, Ball CL, Mawson D, Skinner K, Tooke JE, Shore A (2009). PLASMA LEVELS OF THE NOVEL VASODILATORY GAS HYDROGEN SULFIDE (H2S) ARE ASSOCIATED WITH ADIPOSITY.  Author URL.
Whiteman M, Gooding K, Whatmore J, Ball CI, Mawson D, Skinner K, Shore AC (2009). Plasma Hydrogen Sulfide (H2S) and Correlations with Physical, Clinical and Vascular indices of Obesity, Metabolic Syndrome and type II Diabetes.  Author URL.
Whiteman M, Whatmore JL, Skinner K, Ball C, Gooding KM, Shore AC (2009). Plasma hydrogen sulphide: correlations with clinical indices of micro- and macrovascular function, obesity, metabolic syndrome and type II diabetes.  Author URL.
Blanch EA, Maskell L, Colucci MA, Whatmore JLA, Moody CJ (2009). Sythesis of potential prodrug systems for reductive activation. Prodrugs for anti-angiogenic isoflavones and VEGF receptor tyrosine kinase inhibitory oxindoles. Tetrahedron, 65, 4894-4903.

2008

Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2008). Changes in endothelial cell activation occur in multiple sclerosis lesion formation.  Author URL.
McHarg S, Shore AC, Whatmore JL (2008). Heterogeneity of phospholipase D activation by angiotensin II, lysophosphatidylcholine, and insulin in human endothelial cells. Endothelium, 15(4), 213-218. Abstract.  Author URL.
Busch R, Watson P, Whatmore J, Hall FC (2008). Towards blood-based biomarkers for endothelial dysfunction in systemic autoimmune disease.  Author URL.

2007

Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2007). Alteration in blood vessel density in multiple sclerosis lesions implies a role in brain scarring.  Author URL.
Maskell L, Blanche EA, Colucci MA, Whatmore JL, Moody CJ (2007). Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles. Bioorg Med Chem Lett, 17(6), 1575-1578. Abstract.  Author URL.
Holley J, Eggleton P, Whatmore J, Gutowski N (2007). Temporal changes in endothelial cell activation occur in MS lesion formation. NEURON GLIA BIOLOGY, 2, S35-S35. Author URL.

2006

McHarg S, Shore AC, Whatmore JL (2006). Insulin induced phospholipase D activation in human endothelial cells.  Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Tooke JE, Shore AC (2006). Microvascular function is altered by polymorphisms in the promoter region of the aldose reductase gene in healthy subjects.  Author URL.
Gooding KM, Whatmore JL, Tullett J, Middlebrooke AR, Demaine AG, Jarvis D, Tooke JE, Shore AC (2006). The impact of polymorphisms in the promoter region of the aldose reductase gene on microvascular function in healthy subjects.  Author URL.

2005

JWhatmore, Konopatskaya O, Shore A, Tooke J (2005). A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. Diabetologia, 48(3), 595-604.
Konopatskaya O, Shore AC, Tooke JE, Whatmore JL (2005). A role for heterotrimeric GTP-binding proteins and ERK1/2 in insulin-mediated, nitric-oxide-dependent, cyclic GMP production in human umbilical vein endothelial cells. Diabetologia, 48(3), 595-604. Abstract.  Author URL.
McHarg S, Whatmore J, Shore A (2005). Activation of phospholipase D by angiotensin II in HUVECS and HMVECS.  Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore J (2005). Blood vessel density is increased in chronic MS lesions: Relationship to scarring. EUROPEAN JOURNAL OF NEUROLOGY, 12, 129-129. Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Human lung tumour cells induce changes in human astrocyte phenotype in vitro: Relevance to metastasis evolution. EUROPEAN JOURNAL OF NEUROLOGY, 12, 143-143. Author URL.
Gutowski NJ, Holley JE, Eggleton P, Whatmore JL (2005). Increased blood vessel density in chronic multiple sclerosis lesions.  Author URL.
Gutowski NJ, Maskell L, Eggleton P, Whatmore JL (2005). Lung tumour cells induce changes in astrocyte phenotype in vitro: relevance to brain metastasis evolution.  Author URL.
JWhatmore, Gutowski N, Gveric J, Holley J (2005). Tenascin C induces a quiescent phenotype in cultured adult human astrocytes. Glia, 52(1), 53-58.
Holley JE, Gveric D, Whatmore JL, Gutowski NJ (2005). Tenascin C induces a quiescent phenotype in cultured adult human astrocytes. Glia, 52(1), 53-58. Abstract.  Author URL.

2004

Barker AL, Konopatskaya O, Neal CR, Macpherson JV, Whatmore JL, Winlove CP, Unwin PR, Shore AC (2004). Observation and characterisation of the glycocalyx of viable human endothelial cells using confocal laser scanning microscopy. Physical Chemistry Chemical Physics, 6(5), 1006-1011. Abstract.
Davies MW, Maskell L, Shipman M, Slawin AMZ, Vidot SME, Whatmore JL (2004). Studies toward the synthesis of luminacin D: Assembly of simplified analogues devoid of the epoxide displaying antiangiogenic activity. Organic Letters, 6(22), 3909-3912. Abstract.

2003

Gutowski NJ, Holley JE, Whatmore JL (2003). Brain scarring: Effects of extracellular matrix on astrocyte phenotype.  Author URL.
JWhatmore, Konopatskaya P, Shore A, Tooke J (2003). Insulin and lysophosphatidylcholine synergistically stimulate NO-dependent cGMP production in human endothelial cells. Diabetic Medicine, 20(10), 838-845.
Konopatskaya O, Whatmore JL, Tooke JE, Shore AC (2003). Insulin and lysophosphatidylcholine synergistically stimulate NO-dependent cGMP production in human endothelial cells. Diabet Med, 20(10), 838-845. Abstract.  Author URL.

2002

Whatmore JL, Swann E, Barraja P, Newsome JJ, Bunderson M, Beall HD, Tooke JE, Moody CJ (2002). Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Angiogenesis, 5(1-2), 45-51. Abstract.  Author URL.

2001

Konopatskaya O, Whatmore JL, Shore AC, Tooke JE (2001). Modulation of nitric oxide production by lysophosphatidylcholine in human endothelial cells.  Author URL.

1999

Whatmore J, Wiedemann C, Somerharju P, Swigart P, Cockcroft S (1999). Resynthesis of phosphatidylinositol in permeabilized neutrophils following phospholipase Cbeta activation: transport of the intermediate, phosphatidic acid, from the plasma membrane to the endoplasmic reticulum for phosphatidylinositol resynthesis is not dependent on soluble lipid carriers or vesicular transport. Biochem J, 341 ( Pt 2), 435-444. Abstract.  Author URL.

1998

Fensome A, Whatmore J, Morgan C, Jones D, Cockcroft S (1998). ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils. J Biol Chem, 273(21), 13157-13164. Abstract.  Author URL.

1997

Morgan CP, Sengelov H, Whatmore J, Borregaard N, Cockcroft S (1997). ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils. Biochem J, 325 ( Pt 3), 581-585. Abstract.  Author URL.
Kular G, Loubtchenkov M, Swigart P, Whatmore J, Ball A, Cockcroft S, Wetzker R (1997). Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils. Biochem J, 325 ( Pt 2), 299-301. Abstract.  Author URL.

1996

Whatmore J, Morgan CP, Cunningham E, Collison KS, Willison KR, Cockcroft S (1996). ADP-ribosylation factor 1-regulated phospholipase D activity is localized at the plasma membrane and intracellular organelles in HL60 cells. Biochem J, 320 ( Pt 3), 785-794. Abstract.  Author URL.

1994

Whatmore J, Cronin P, Cockcroft S (1994). ARF1-regulated phospholipase D in human neutrophils is enhanced by PMA and MgATP. FEBS Lett, 352(2), 113-117. Abstract.  Author URL.
Whatmore JLA, Allan D (1994). Phospholipid asymmetry in plasma membrane vesicles derived from BHK cells. Biochimica and Biophysica Acta, 1192, 88-94.
Kallen KJ, Allan D, Whatmore J, Quinn P (1994). Synthesis of surface sphingomyelin in the plasma membrane recycling pathway of BHK cells. Biochim Biophys Acta, 1191(1), 52-58. Abstract.  Author URL.
THOMAS G, FENSOME A, WHATMORE J, GENY B, COCKCROFT S (1994). THE REGULATION OP PHOSPHOLIPASE-D BY ARFS. JOURNAL OF NEUROCHEMISTRY, 63, S29-S29. Author URL.

1993

Whatmore J, Quinn P, Allan D (1993). Plasma membrane vesicles from BHK and HL60 cells treated with merocyanine 540 and iodoacetamide. Biochim Biophys Acta, 1152(2), 300-306. Abstract.  Author URL.

1992

Whatmore JLA, Tang EKY, Hickman JA (1992). Cytoskeletal proteolysis during calcium-induced morphological transitions of human erythrocytes. Experimental Cell Research(200), 316-325.

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