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Dr Irina A. Tikhonova

Research Fellow

 6084

 +44 (0) 1392 726084

 South Cloisters 3.09

 

South Cloisters, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK

After graduating from Kazan Federal University with a degree in Applied Mathematics and Computer Science, Irina had a short stint as a software engineer working on an EEG software for diagnosis of epilepsies, and a database of outdoor air pollution. She then did her PhD at the Institute of Theoretical and Experimental Biophysics in Pushchino, the Biological Centre of Russian Academy of Sciences, where she studied mechanisms underlying irregular spatio-temporal dynamics in marine populations.

During her research career, Irina has been involved in many projects related to epidemiological modelling of human, animal and plant diseases. She utilised a vast range of different methodological approaches including mean-field, agent-based and statistical models. Irina worked at a number of leading research institutions such as the University of Cambridge, Yale School of Medicine, the Universities of California and New Mexico.

Irina joined the ESMI (PenTAG) team as a health economics modeller in March, 2015. She is the convenor for the Health Technology Assessment Module (CSC3004).

 

Qualifications

  • PhD Applied Mathematics (Institute for Theoretical and Experimental Biophysics of Russian Academy of Sciences)
  • MSc Applied Mathematics and Computer Science, Red diploma, equivalent of summa cum laude (Kazan State University)

Research

Research interests

  • Mathematical biology: biological pattern formation, chaos and fractals
  • Computational epidemiology
  • Complex networks
  • Computational statistics
  • Health economics

 

Research projects

 

Links


Key publications | Publications by category | Publications by year

Key publications


Tikhonova I, Long L, Ocean N, Barnish M, Robinson S, Nikram E, Bello S, Dodman S, Halpin D, Hoyle M, et al (2018). Benralizumab for treating severe asthma: a Single Technology Appraisal.
Tikhonova I, Huxley N, Snowsill T, Crathorne L, Varley-Campbell J, Napier M, Hoyle M (2018). Economic Analysis of First-Line Treatment with Cetuximab or Panitumumab for RAS Wild-Type Metastatic Colorectal Cancer in England. Pharmacoeconomics Full text.
Tikhonova I, Jones-Hughes T, Dunham J, Warren F, Robinson S, Stephens P, Hoyle M (2017). Olaratumab in Combination with Doxorubicin for the Treatment of Advanced Soft Tissue Sarcoma: an Evidence Review Group Perspective of a National Institute for Health and Care Excellence Single Technology Appraisal. Pharmacoeconomics Full text.
Tikhonova I, Jones-Hughes T, Dunham J, Warren F, Robinson S, Stephens P, Hoyle M (2017). Olaratumab in combination with doxorubicin for treating advanced soft tissue sarcoma: a Single Technology Appraisal.
Huxley N, Crathorne L, Varley-Campbell J, Tikhonova I, Snowsill T, Briscoe S, Peters J, Bond M, Napier M, Hoyle M, et al (2017). The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectal cancer: a systematic review and economic evaluation. Health Technol Assess, 21(38), 1-294. Abstract.  Author URL.  Full text.
Tikhonova IA, Hoyle MW, Snowsill TM, Cooper C, Varley-Campbell JL, Rudin CE, Mujica Mota RE (2016). Azacitidine for Treating Acute Myeloid Leukaemia with More Than 30 % Bone Marrow Blasts: an Evidence Review Group Perspective of a National Institute for Health and Care Excellence Single Technology Appraisal. Pharmacoeconomics Open, 35(3), 363-373. Abstract.  Full text.

Publications by category


Journal articles

Tikhonova I, Huxley N, Snowsill T, Crathorne L, Varley-Campbell J, Napier M, Hoyle M (2018). Economic Analysis of First-Line Treatment with Cetuximab or Panitumumab for RAS Wild-Type Metastatic Colorectal Cancer in England. Pharmacoeconomics Full text.
Tikhonova I, Jones-Hughes T, Dunham J, Warren F, Robinson S, Stephens P, Hoyle M (2017). Olaratumab in Combination with Doxorubicin for the Treatment of Advanced Soft Tissue Sarcoma: an Evidence Review Group Perspective of a National Institute for Health and Care Excellence Single Technology Appraisal. Pharmacoeconomics Full text.
Huxley N, Crathorne L, Varley-Campbell J, Tikhonova I, Snowsill T, Briscoe S, Peters J, Bond M, Napier M, Hoyle M, et al (2017). The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectal cancer: a systematic review and economic evaluation. Health Technol Assess, 21(38), 1-294. Abstract.  Author URL.  Full text.
Tikhonova IA, Hoyle MW, Snowsill TM, Cooper C, Varley-Campbell JL, Rudin CE, Mujica Mota RE (2016). Azacitidine for Treating Acute Myeloid Leukaemia with More Than 30 % Bone Marrow Blasts: an Evidence Review Group Perspective of a National Institute for Health and Care Excellence Single Technology Appraisal. Pharmacoeconomics Open, 35(3), 363-373. Abstract.  Full text.
Medvinskii AB, Petrovskii SV, Tikhonova IA, Tikhonov DA, Li B-L, Venturino E, Malchow H, Ivanitskii GR (2007). Spatio-temporal pattern formation, fractals, and chaos in conceptual ecological models as applied to coupled plankton-fish dynamics. Physics-Uspekhi, 45(1), 27-57.
Medvinsky AB, Tikhonova IA, Li B-L, Malchow H (2004). Time delay as a key factor of model plankton dynamics. Comptes Rendus Biologies, 327(3), 277-282.
Tikhonova IA, Li BL, Malchow H, Medvinskiĭ AB (2003). Effect of the rate of phytoplankton growth on the spaced-time dynamics of plankton communities in an homogeneous environment. Biofizika, 48(5), 891-899. Abstract.
Medvinsky AB, Tikhonova IA, Li B-L, Malchow H (2003). Interrelation between spatial and temporal variations in plankton biomass: a study by mathematical modeling. Biophysics, 104-110.
Medvedinskiĭ AB, Tikhonova IA, Li BL, Malchow H (2003). [Interdependence of plankton spatial distribution and plancton biomass temporal oscillations: mathematical simulation]. Biofizika, 48(1), 104-110. Abstract.  Author URL.
Medvinsky AB, Tikhonova IA, Petrovskii SV, Malchow H, Venturino E (2002). Chaos and order in plankton dynamics. Complex behavior of a simple model. Zh Obshch Biol, 63(2), 149-158. Abstract.  Author URL.
Medvinsky AB, Petrovskii SV, Tikhonova IA, Malchow H, Li B-L (2002). Spatiotemporal Complexity of Plankton and Fish Dynamics. SIAM Review, 44(3), 311-370.
Medvinsky AB, Petrovskii SV, Tikhonov DA, Tikhonova IA, Ivanitsky GR, Venturino E, Malchow H (2001). Biological factors underlying regularity and chaos in aquatic ecosystems: Simple models of complex dynamics. Journal of Biosciences, 26(1), 77-108.
Medvinsky AB, Petrovskii SV, Tikhonova IA, Venturino E, Malchow H (2001). Chaos and regular dynamics in model multi-habitat plankton-fish communities. J Biosci, 26(1), 109-120. Abstract.  Author URL.
Medvinsky AB, Tikhonova IA, Aliev RR, Li BL, Lin ZS, Malchow H (2001). Patchy environment as a factor of complex plankton dynamics. Phys Rev E Stat Nonlin Soft Matter Phys, 64(2 Pt 1). Abstract.  Author URL.
Tikhonova IA, Arino O, Ivanitskiĭ GR, Malchow H, Medvinskiĭ AB (2000). Dependence of the fish school movement and plankton special distribution on the phytoplankton growth rate. Biofizika, 45(2), 352-359. Abstract.
Medvinsky AB, Tikhonova IA, Li B-L, Malcow H (2000). The role of carnivorous zooplankton in dynamics of trophic interaction of fish and plankton. Biofizika / Biophysics, 45, 746-750.

Conferences

Tikhonova IA, Hoyle M, Snowsill T, Cooper C, Varley-Campbell J, Rudin C, Mujica Mota R (2016). Azacitidine for Treating Acute Myeloid Leukaemia: a Nice Single Technology Appraisal. ISPOR.
Tikhonova IA, Hoyle M, Snowsill T, Crathorne L, Varley-Campbell J, Peters J, Briscoe S, Bond M, Huxley N (2016). Cost Effectiveness of Cetuximab and Panitumumab for First-Line RAS WT Metastatic Colorecal Cancer. ISPOR.
Medvinsky AB, Tikhonova IA, Li B-L, Malchow H (2003). Parametrically irregular chaos in ecological communities. Topical problems of nonlinear wave physics. 6th - 11th Sep 2003.

Reports

Tikhonova I, Long L, Ocean N, Barnish M, Robinson S, Nikram E, Bello S, Dodman S, Halpin D, Hoyle M, et al (2018). Benralizumab for treating severe asthma: a Single Technology Appraisal.
Tikhonova I, Jones-Hughes T, Dunham J, Warren F, Robinson S, Stephens P, Hoyle M (2017). Olaratumab in combination with doxorubicin for treating advanced soft tissue sarcoma: a Single Technology Appraisal.
Mujica-mota R, Varley-Campbell J, Tikhonova I, Cooper C, Hoyle MW, Rudin C, Rule S, Snowsill T (2016). Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts: a Single Technology Appraisal. Author URL.  Full text.
Varley-Campbell J, Mujica-Mota R, Tikhonova I, Cooper C, Griffin E, Haasova M, Peters J, Lucherini S, Talens-Bou J, Long L, et al (2016). Everolimus, lutetium-177 DOTATATE and sunitinib for treating unresectable or metastatic neuroendocrine tumours with disease progression.
Huxley N, Crathorne L, Varley-Campbell J, Tikhonova I, Snowsill T, Briscoe S, Peters J, Bond M, Napier M, Hoyle MW, et al (2015). Cetuximab (review of TA176) and panitumumab (partial review of TA240) for the first line treatment of metastatic colorectal cancer. MTA for NICE. Author URL.

Publications by year


2018

Tikhonova I, Long L, Ocean N, Barnish M, Robinson S, Nikram E, Bello S, Dodman S, Halpin D, Hoyle M, et al (2018). Benralizumab for treating severe asthma: a Single Technology Appraisal.
Tikhonova I, Huxley N, Snowsill T, Crathorne L, Varley-Campbell J, Napier M, Hoyle M (2018). Economic Analysis of First-Line Treatment with Cetuximab or Panitumumab for RAS Wild-Type Metastatic Colorectal Cancer in England. Pharmacoeconomics Full text.

2017

Tikhonova I, Jones-Hughes T, Dunham J, Warren F, Robinson S, Stephens P, Hoyle M (2017). Olaratumab in Combination with Doxorubicin for the Treatment of Advanced Soft Tissue Sarcoma: an Evidence Review Group Perspective of a National Institute for Health and Care Excellence Single Technology Appraisal. Pharmacoeconomics Full text.
Tikhonova I, Jones-Hughes T, Dunham J, Warren F, Robinson S, Stephens P, Hoyle M (2017). Olaratumab in combination with doxorubicin for treating advanced soft tissue sarcoma: a Single Technology Appraisal.
Huxley N, Crathorne L, Varley-Campbell J, Tikhonova I, Snowsill T, Briscoe S, Peters J, Bond M, Napier M, Hoyle M, et al (2017). The clinical effectiveness and cost-effectiveness of cetuximab (review of technology appraisal no. 176) and panitumumab (partial review of technology appraisal no. 240) for previously untreated metastatic colorectal cancer: a systematic review and economic evaluation. Health Technol Assess, 21(38), 1-294. Abstract.  Author URL.  Full text.

2016

Tikhonova IA, Hoyle MW, Snowsill TM, Cooper C, Varley-Campbell JL, Rudin CE, Mujica Mota RE (2016). Azacitidine for Treating Acute Myeloid Leukaemia with More Than 30 % Bone Marrow Blasts: an Evidence Review Group Perspective of a National Institute for Health and Care Excellence Single Technology Appraisal. Pharmacoeconomics Open, 35(3), 363-373. Abstract.  Full text.
Tikhonova IA, Hoyle M, Snowsill T, Cooper C, Varley-Campbell J, Rudin C, Mujica Mota R (2016). Azacitidine for Treating Acute Myeloid Leukaemia: a Nice Single Technology Appraisal. ISPOR.
Mujica-mota R, Varley-Campbell J, Tikhonova I, Cooper C, Hoyle MW, Rudin C, Rule S, Snowsill T (2016). Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts: a Single Technology Appraisal. Author URL.  Full text.
Tikhonova IA, Hoyle M, Snowsill T, Crathorne L, Varley-Campbell J, Peters J, Briscoe S, Bond M, Huxley N (2016). Cost Effectiveness of Cetuximab and Panitumumab for First-Line RAS WT Metastatic Colorecal Cancer. ISPOR.
Varley-Campbell J, Mujica-Mota R, Tikhonova I, Cooper C, Griffin E, Haasova M, Peters J, Lucherini S, Talens-Bou J, Long L, et al (2016). Everolimus, lutetium-177 DOTATATE and sunitinib for treating unresectable or metastatic neuroendocrine tumours with disease progression.

2015

Huxley N, Crathorne L, Varley-Campbell J, Tikhonova I, Snowsill T, Briscoe S, Peters J, Bond M, Napier M, Hoyle MW, et al (2015). Cetuximab (review of TA176) and panitumumab (partial review of TA240) for the first line treatment of metastatic colorectal cancer. MTA for NICE. Author URL.

2007

Medvinskii AB, Petrovskii SV, Tikhonova IA, Tikhonov DA, Li B-L, Venturino E, Malchow H, Ivanitskii GR (2007). Spatio-temporal pattern formation, fractals, and chaos in conceptual ecological models as applied to coupled plankton-fish dynamics. Physics-Uspekhi, 45(1), 27-57.

2004

Medvinsky AB, Tikhonova IA, Li B-L, Malchow H (2004). Time delay as a key factor of model plankton dynamics. Comptes Rendus Biologies, 327(3), 277-282.

2003

Tikhonova IA, Li BL, Malchow H, Medvinskiĭ AB (2003). Effect of the rate of phytoplankton growth on the spaced-time dynamics of plankton communities in an homogeneous environment. Biofizika, 48(5), 891-899. Abstract.
Medvinsky AB, Tikhonova IA, Li B-L, Malchow H (2003). Interrelation between spatial and temporal variations in plankton biomass: a study by mathematical modeling. Biophysics, 104-110.
Medvinsky AB, Tikhonova IA, Li B-L, Malchow H (2003). Parametrically irregular chaos in ecological communities. Topical problems of nonlinear wave physics. 6th - 11th Sep 2003.
Medvedinskiĭ AB, Tikhonova IA, Li BL, Malchow H (2003). [Interdependence of plankton spatial distribution and plancton biomass temporal oscillations: mathematical simulation]. Biofizika, 48(1), 104-110. Abstract.  Author URL.

2002

Medvinsky AB, Tikhonova IA, Petrovskii SV, Malchow H, Venturino E (2002). Chaos and order in plankton dynamics. Complex behavior of a simple model. Zh Obshch Biol, 63(2), 149-158. Abstract.  Author URL.
Medvinsky AB, Petrovskii SV, Tikhonova IA, Malchow H, Li B-L (2002). Spatiotemporal Complexity of Plankton and Fish Dynamics. SIAM Review, 44(3), 311-370.

2001

Medvinsky AB, Petrovskii SV, Tikhonov DA, Tikhonova IA, Ivanitsky GR, Venturino E, Malchow H (2001). Biological factors underlying regularity and chaos in aquatic ecosystems: Simple models of complex dynamics. Journal of Biosciences, 26(1), 77-108.
Medvinsky AB, Petrovskii SV, Tikhonova IA, Venturino E, Malchow H (2001). Chaos and regular dynamics in model multi-habitat plankton-fish communities. J Biosci, 26(1), 109-120. Abstract.  Author URL.
Medvinsky AB, Tikhonova IA, Aliev RR, Li BL, Lin ZS, Malchow H (2001). Patchy environment as a factor of complex plankton dynamics. Phys Rev E Stat Nonlin Soft Matter Phys, 64(2 Pt 1). Abstract.  Author URL.

2000

Tikhonova IA, Arino O, Ivanitskiĭ GR, Malchow H, Medvinskiĭ AB (2000). Dependence of the fish school movement and plankton special distribution on the phytoplankton growth rate. Biofizika, 45(2), 352-359. Abstract.
Medvinsky AB, Tikhonova IA, Li B-L, Malcow H (2000). The role of carnivorous zooplankton in dynamics of trophic interaction of fish and plankton. Biofizika / Biophysics, 45, 746-750.

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