COLLEGE OF MEDICINE AND HEALTH
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Dr Harry Green

Dr Harry Green

Independent Research Fellow

 07979 464009

 RILD Building 3.03

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Harry is an independent research fellow in diabetes progression with a background in mathematical modelling. His PhD was in mathematical modelling in cardiac electrophysiology with Prof. John Terry, in which he developed techniques to use simulations of biophysics to provide information to a cardiologist during atrial fibrillation therapy. He moved from the maths department to the medical school to work in IBD Pharmacogenetics where he developed predictive models for treatment failure in Anti-TNF therapy for luminal Crohn's disease, identified genetic variants associated with disease risk and adverse event risk, and used genetic epidemiology to identify causal risk factors for gastrointestinal conditions.

Harry started working as an Independent Research Fellow within EXCEED in 2020, and his research focuses on building statistical models to explore progression rates in type 2 diabetes. He also researches genetics and aetiology of diabetic complications.

Outside of work, Harry is a martial artist that has trained in a variety of styles, most notably Kukkiwon Taekwondo. Harry currently trains Muay Thai with FSC Muay Thai in Exeter. Harry is also a regular speaker at the Pint of Science festival.

Qualifications

  • PhD in Mathematical Modelling of Cardiac Electrophysiology, University of Exeter
  • MSc (res) in Mathematical Modelling of Population Dynamics, Oxford Brookes University
  • BSc in Mathematics at the University of Portsmouth

 

Research group links

Research

Research interests

Harry’s research interests are in the application of mathematical and statistical modelling to help understand human physiology and predict outcomes using large data resources. At the moment, Harry’s main project is building models of diabetes progression, defined by HbA1c gradients and treatment escalation, with the goal of understanding why different people progress at different rates and eventually building predictive tools that could help a clinician understand whether a patient is likely to progress quickly.

Harry is also interested in genetics and causal inference, particularly in the roles of techniques such as genome-wide association studies and Mendelian Randomisation to explore causal risk factors for human diseases.

Research projects

  • Statistical Modelling of Diabetes Progression
  • Genetic Epidemiology of Diabetic Complications

Links


Publications

Key publications | Publications by category | Publications by year

Key publications


Bewshea CM, Ahmad T, Kennedy N, Goodhand J, McDonald T, Green H (2019). Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study. Lancet Gastroenterology and Hepatology Full text.

Publications by category


Journal articles

Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (In Press). A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors.  Abstract.
Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (2021). A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor. PLoS Genet, 17(6). Abstract.  Author URL.
Nice R, Chanchlani N, Green H, Bewshea C, Ahmad T, Goodhand JR, McDonald TJ, Perry MH, Kennedy NA (2021). Validating the positivity thresholds of drug-tolerant anti-infliximab and anti-adalimumab antibody assays. Aliment Pharmacol Ther, 53(1), 128-137. Abstract.  Author URL.
Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical features and genetic risk of demyelination following anti-TNF treatment. J Crohns Colitis Abstract.  Author URL.  Full text.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1270-1281. Abstract.  Full text.
Hamilton B, Green H, Heerasing N, Hendy P, Moore L, Chanchlani N, Walker G, Bewshea C, Kennedy NA, Ahmad T, et al (2020). Incidence and prevalence of inflammatory bowel disease in Devon, UK. Frontline Gastroenterology, 12(6), 461-470. Abstract.
Walker GJ, Lin S, Chanchlani N, Thomas A, Hendy P, Heerasing N, Moore L, Green HD, Chee D, Bewshea C, et al (2020). Quality improvement project identifies factors associated with delay in IBD diagnosis. Alimentary Pharmacology & Therapeutics, 52(3), 471-480.
Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract.  Author URL.  Full text.
Bewshea CM, Ahmad T, Kennedy N, Goodhand J, McDonald T, Green H (2019). Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study. Lancet Gastroenterology and Hepatology Full text.
Green HD, Thomas G, Terry JR (2017). Signal reconstruction of pulmonary vein recordings using a phenomenological mathematical model: Application to pulmonary vein isolation therapy. Frontiers in Physiology, 8(JUL). Abstract.  Full text.

Publications by year


In Press

Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (In Press). A genome wide association study of frozen shoulder identifies a common variant of WNT7B and diabetes as causal risk factors.  Abstract.

2021

Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (2021). A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor. PLoS Genet, 17(6). Abstract.  Author URL.
Nice R, Chanchlani N, Green H, Bewshea C, Ahmad T, Goodhand JR, McDonald TJ, Perry MH, Kennedy NA (2021). Validating the positivity thresholds of drug-tolerant anti-infliximab and anti-adalimumab antibody assays. Aliment Pharmacol Ther, 53(1), 128-137. Abstract.  Author URL.

2020

Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical features and genetic risk of demyelination following anti-TNF treatment. J Crohns Colitis Abstract.  Author URL.  Full text.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1270-1281. Abstract.  Full text.
Hamilton B, Green H, Heerasing N, Hendy P, Moore L, Chanchlani N, Walker G, Bewshea C, Kennedy NA, Ahmad T, et al (2020). Incidence and prevalence of inflammatory bowel disease in Devon, UK. Frontline Gastroenterology, 12(6), 461-470. Abstract.
Walker GJ, Lin S, Chanchlani N, Thomas A, Hendy P, Heerasing N, Moore L, Green HD, Chee D, Bewshea C, et al (2020). Quality improvement project identifies factors associated with delay in IBD diagnosis. Alimentary Pharmacology & Therapeutics, 52(3), 471-480.

2019

Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract.  Author URL.  Full text.
Bewshea CM, Ahmad T, Kennedy N, Goodhand J, McDonald T, Green H (2019). Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study. Lancet Gastroenterology and Hepatology Full text.

2017

Green HD, Thomas G, Terry JR (2017). Signal reconstruction of pulmonary vein recordings using a phenomenological mathematical model: Application to pulmonary vein isolation therapy. Frontiers in Physiology, 8(JUL). Abstract.  Full text.

Harry_Green Details from cache as at 2021-10-24 13:04:46

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External Engagement and Impact

Awards

  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2013
  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2015
  • Nominated - Best Postgraduate Demonstrator, University of Exeter, 2015
  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2017
  • Runner up – Best Poster Presentation, BioDynamics 2016

Invited lectures & workshops

  • Mathematical Modelling of the Pulmonary Vein signals during Radiofrequency Ablation of Atrial Fibrillation - Institute of Mathematics and its Applications Early Career Mathematicians Conference – Keynote, 2015
  • Mathematical Modelling of Atrial Electrograms and Application to Radiofrequency Ablation Treatment – University Hospital Bordeaux – Invited International Speaker, 2015

Teaching

While in the maths department, Harry taught Dynamics, Programming for Mathematics, Advanced Calculus, Calculus and Geometry, Probability and Discrete Mathematics, Differential Equations, and Mathematical Investigations at undergraduate level.

This year, Harry will be teaching Coding for Medical scientists at undergraduate level and delivering a workshop on GP record analysis for the Stratified Medicine module on MSc Health Data Science.

Supervision / Group

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