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Harry Green

Postdoctoral Research Fellow

07979 464009

RILD Building 3.03

I’m an applied mathematician with a background in the development of mathematical models of biological processes, and applications in medicine. I completed my BSc in Mathematics from the University of Portsmouth, specialising in nonlinear dynamical systems and chaos. From there I moved to Oxford Brookes for an MSc by Research in Applied Mathematics, working on mathematical models of predator-prey dynamics. I began to focus on mathematical techniques in medicine when I started working with Professor John Terry on my PhD project in mathematical modelling of cardiac rhythms in health and disease.

The PhD project focused on the development of mathematical tools to help a cardiologist determine the optimal place to perform radiofrequency ablation treatment for atrial fibrillation when the electrograms used to guide the treatment are not being properly recorded. This involved building a mathematical model of the underlying electrophysiology using a reaction-diffusion equation, developing optimisation tools to train the model to the good bits of data, and using the rest of the simulation to provide a representation of what the electrograms would look like if they were well recorded. Using the mathematical simulations to make decisions results in a statistically significant improvement in clinical decision making.

In September 2017 I joined the University of Exeter Medical School as a postdoctoral research fellow in bioinformatics, working on pharmacogenomics of irritable bowel disease, mainly on the PANTS database (https://www.pantsdb.co.uk/#/home) with Mike Weedon and Tariq Ahmad. The goal of this project is to understand more clearly the clinical, serological and genetic factors that determine primary non-response, loss of response and adverse drug reactions to anti-TNF drugs in patients with active luminal Crohn’s disease.

Qualifications

  • PhD Applied Mathematics – University of Exeter
  • MSc by Research Applied Mathematics – Oxford Brookes University
  • BSc Mathematics – University of Portsmouth

 

Research

Research interests

My research interests are in development and application of mathematical and statistical techniques with practical clinical use. My past research experience has focused on the devleopment of mathematical models of the cardiac system for the development of decision support tools. Currently, my research interests are in analysis of genetic biomarkers for response to anti-TNF treatment for luminal Crohn's disease.

Awards

  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2013
  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2015
  • Nominated - Best Postgraduate Demonstrator, University of Exeter, 2015
  • Winner - Best Postgraduate Demonstrator, Department of Mathematics and Computer Science, 2017
  • Runner up – Best Poster Presentation, BioDynamics 2016

Invited lectures & workshops

  • Mathematical Modelling of the Pulmonary Vein signals during Radiofrequency Ablation of Atrial Fibrillation - Institute of Mathematics and its Applications Early Career Mathematicians Conference – Keynote, 2015
  • Mathematical Modelling of Atrial Electrograms and Application to Radiofrequency Ablation Treatment – University Hospital Bordeaux – Invited International Speaker, 2015

In my previous role as a teaching consultant in mathematics, I taught a range of courses in the first year, including dynamics, elementary calculus, advanced calculus, programming for mathematics, and mathematical investigations.

 

 

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