COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Francesco Casanova

Dr Francesco Casanova

Research Fellow

 RILD Building Level 3

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Francesco Casanova obtained his PhD in Exercise Physiology from Bangor University and in 2010 joined the University of Exeter working in the Diabetes & Vascular Medicine Research Centre led by Professor Angela Shore. He has been working as an Associate Research Fellow on the SUMMIT project (http://www.imi-summit.eu/), an IMI funded project with 29 partners.

Francesco ufficially joined the Complex Traits Genomics team in 2019 after collaborating with the team for a few years. Francesco is now working with Dr Jess Tyrrell to explore causal relationships between metabolic traits, such as obesity and type 2 diabetes, and mental health traits.

Qualifications

PhD

BSc

AFHEA

Research

Research interests

Francesco's research is focusing on the association between metabolic traits (for example obesity and type 2 diabetes) and mental health phenotypes using Mendelian Randomization and Gene by Environment interaction techniques, amongst others. He is interested in exploring how the association between metabolic and mental health traits differs depending on ethnicity and psycosocial factors, currently focusing on European and Chinese populations using the UK Biobank and the China Kadoorie Biobank. Francesco's research is also investigating the positive role of physical activity on mental health outcomes.

Research projects


 

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Frayling TM, Beaumont RN, Jones SE, Yaghootkar H, Tuke MA, Ruth KS, Casanova F, West B, Locke J, Sharp S, et al (In Press). A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure.  Abstract.
Casanova F, Gooding K, Shore A, Adingupu D, Mawson D, Ball C, Anning C, Aizawa K, Gates P, Strain W, et al (In Press). Weight change and sulphonylurea therapy are related to three-year change in microvascular function in people with type 2 diabetes. Diabetologia
Elyas S, Adingupu D, Aizawa K, Casanova F, Gooding K, Fulford J, Mawson D, Gates PE, Shore AC, Strain D, et al (2021). Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets. Aging, 13(18), 22030-22039.
Casanova F, O'Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins E, Freathy R, Hagenaars S, Frayling TM, Yaghootkar H, et al (2021). Higher adiposity and mental health: Causal inference using Mendelian randomisation. Hum Mol Genet Abstract.  Author URL.
Meertens R, Knapp KM, Strain WD, Casanova F, Ball S, Fulford J, Thorn C (2021). In vivo Measurement of Intraosseous Vascular Haemodynamic Markers in Human Bone Tissue Utilising Near Infrared Spectroscopy. Frontiers in Physiology, 12 Abstract.
Aizawa K, Casanova F, Gates PE, Mawson DM, Gooding KM, Strain WD, Östling G, Nilsson J, Khan F, Colhoun HM, et al (2021). Reservoir-Excess Pressure Parameters Independently Predict Cardiovascular Events in Individuals with Type 2 Diabetes. Hypertension, 78(1), 40-50. Abstract.
Cresswell M, Casanova F, Beaumont RN, Wood AR, Ronan N, Hilton MP, Tyrrell J (2021). Understanding Factors That Cause Tinnitus: a Mendelian Randomization Study in the UK Biobank. Ear Hear Abstract.  Author URL.
O'Loughlin J, Casanova F, Jones SE, Hagenaars SP, Beaumont RN, Freathy RM, Watkins ER, Vetter C, Rutter MK, Cain SW, et al (2021). Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health. Mol Psychiatry Abstract.  Author URL.
Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract.  Author URL.
Aizawa K, Casanova F, Mawson D, Gooding K, Elyas S, Adingupu D, Strain D, Gates P, Shore A (2020). P17 Comparisons of Carotid-femoral Pulse Wave Velocity Obtained from the Surface-distance Measurement and from the Population-derived Distance Formula: Associations with Macro- and Microvascular Alterations in Older Adults. Artery Research, 25(Supplement 1).
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract.  Author URL.
Aizawa K, Ramalli A, Sbragi S, Tortoli P, Casanova F, Morizzo C, Thorn CE, Shore AC, Gates PE, Palombo C, et al (2019). Arterial wall shear rate response to reactive hyperaemia is markedly different between young and older humans. J Physiol, 597(16), 4151-4163. Abstract.  Author URL.
Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.
van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, et al (2018). A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects with Type 2 Diabetes. Diabetes, 67(7), 1414-1427. Abstract.  Author URL.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn CE, Shore AC, Gates PE, Palombo C, et al (2018). Brachial artery vasodilatory response and wall shear rate determined by multigate Doppler in a healthy young cohort. J Appl Physiol (1985), 124(1), 150-159. Abstract.  Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Östling G, Khan F, Colhoun HM, Palombo C, et al (2018). Reservoir pressure integral is independently associated with the reduction in renal function in an older population. Artery Research, 24(C), 72-73.
Meertens RM, Casanova F, Knapp KM, Thorn C, Strain WD (2018). Use of Near-Infrared Systems for Investigations of Hemodynamics in Human in Vivo Bone Tissue: a Systematic Review. Journal of Orthopaedic Research
Shore AC, Colhoun HM, Natali A, Palombo C, Khan F, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, et al (2018). Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: the SUMMIT VIP Study. Diabetes Care, 41(10), 2212-2219. Abstract.  Author URL.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn C, Shore A, Gates P, Palombo C, et al (2017). Influence of brachial artery stiffness on flow-mediated dilatation in healthy young and older populations. Artery Research, 20(C).
Casanova F, Adingupu DD, Adams F, Gooding KM, Looker HC, Aizawa K, Dove F, Elyas S, Belch JJF, Gates PE, et al (2017). The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control. Cardiovasc Diabetol, 16(1). Abstract.  Author URL.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn C, Shore A, Gates P, Palombo C, et al (2017). Wall shear rate and brachial artery flow-mediated dilatory response between healthy young and older populations using multi-gate spectral Doppler ultrasound. Artery Research, 20(C).
Gonçalves I, Edsfeldt A, Colhoun HM, Shore AC, Palombo C, Natali A, Fredrikson GN, Björkbacka H, Wigren M, Bengtsson E, et al (2016). Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. BMC Cardiovasc Disord, 16(1). Abstract.  Author URL.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn C, Shore A, Gates P, Palombo C, et al (2016). Brachial artery flow-mediated dilatation: different patterns of wall shear rate increase during reactive hyperaemia. Artery Research, 16(C), 67-68.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE (2016). Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Ultrasound Med Biol, 42(5), 1130-1137. Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE (2016). Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Physiol Rep, 4(12). Abstract.  Author URL.
Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, et al (2016). Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES. J Biol Chem, 291(19), 10210-10227. Abstract.  Author URL.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The Effects of Lumbar Sympathectomy on Bone and Soft Tissue Haemodynamics of the Leg recorded using Near Infrared Spectroscopy: a Case Report. Journal of Biomedical Engineering and Informatics, 3, 28-32.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu DD, Gooding KM, Strain WD, Park CM, Parker KH, Gates PE, et al (2016). [PP.11.05] RESERVOIR-PRESSURE ANALYSIS IN TYPE 2 DIABETES INDIVIDUALS WITH CARDIOVASCULAR DISEASE. Journal of Hypertension, 34(Supplement 2), e178-e178.
Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW, et al (2015). Blood Oxygen Saturation After Ischemia is Altered with Abnormal Microvascular Reperfusion. Microcirculation, 22(4), 294-305. Abstract.  Author URL.
Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, et al (2015). Elevated Plasma Levels of MMP-12 Are Associated with Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects with Type 2 Diabetes. Arterioscler Thromb Vasc Biol, 35(7), 1723-1731. Abstract.  Author URL.
Shore AC, Colhoun HM, Natali A, Palombo C, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, et al (2015). Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study. Journal of Internal Medicine, 278(3), 291-302. Abstract.
Shore AC, Colhoun HM, Natali A, Palombo C, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, et al (2015). Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study. J Intern Med, 278(3), 291-302. Abstract.  Author URL.
Aizawa. K, Casanova F, Mawson D, Elyas S, Adingupu D, Gooding K, Strain D, Shore A, Gates P (2015). P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS. Artery Research, 12(C), 11-11.
Cooney JK, Moore JP, Ahmad YA, Jones JG, Lemmey AB, Casanova F, Maddison PJ, Thom JM (2013). A simple step test to estimate cardio-respiratory fitness levels of rheumatoid arthritis patients in a clinical setting. Int J Rheumatol, 2013 Abstract.  Author URL.
Adingupu DD, Elyas S, Casanova F, Gates PE, Shore AC, Strain WD (2013). Microvascular autoregulatory response to ischaemia and pulse pressure. JOURNAL OF HUMAN HYPERTENSION, 27(10), 652-653. Author URL.
Adingupu DD, Thorn C, Casanova F, Elyas S, Gates PE, Strain WD, Shore AC (2013). Microvascular autoregulatory response to ischaemia in the skin and association with mean blood oxygen saturation. JOURNAL OF HUMAN HYPERTENSION, 27(10), 640-641. Author URL.
Lemmey AB, Marcora SM, Chester K, Wilson S, Casanova F, Maddison PJ (2009). Effects of high-intensity resistance training in patients with rheumatoid arthritis: a randomized controlled trial. Arthritis Rheum, 61(12), 1726-1734. Abstract.  Author URL.
Marcora SM, Casanova F, Fortes MB, Maddison PJ (2007). Validity and reliability of the Siconolfi Step Test for assessment of physical fitness in patients with systemic lupus erythematosus. Arthritis Rheum, 57(6), 1007-1011. Abstract.  Author URL.
Marcora S, Casanova F, Williams E, Jones J, Elamanchi R, Lemmey A (2006). Preliminary evidence for cachexia in patients with well-established ankylosing spondylitis. RHEUMATOLOGY, 45(11), 1385-1388. Author URL.
Marcora S, Casanova F, Williams E, Jones J, Elamanchi R, Lemmey A (2006). Preliminary evidence for cachexia in patients with well-established ankylosing spondylitis. Rheumatology (Oxford), 45(11), 1385-1388. Abstract.  Author URL.
Fortes MB, Casanova F, Marcora S (2006). Reliability and Validity of the Siconolfi Step-Test in Patients with Systemic Lupus Erythematosus. Medicine & Science in Sports & Exercise, 38(Supplement).
La Torre A, Impellizzeri FM, Rampinini E, Casanova F, Alberti G, Marcora SM (2005). Cardiovascular responses to aerobic step dance sessions with and without appendicular overload. J Sports Med Phys Fitness, 45(3), 264-269. Abstract.  Author URL.

Conferences

Hagenaars S, Casanova F, Gillett A, Green H, Lewis C, Tyrrell J (2021). ASSESSING THE IMPACT OF DEPRESSION DIAGNOSIS ON DIABETES AND LIFETIME HYPERGLYCAEMIA.  Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Khan F, Colhoun HM, Palombo C, et al (2021). ELEVATED EXCESS PRESSURE INTEGRAL IS ASSOCIATED WITH VASCULAR BIOMARKERS OF SUBCLINICAL ATHEROSCLEROSIS IN OLDER ADULTS.  Author URL.
O'Loughlin J, Casanova F, Hughes A, Bowden J, Watkins E, Freathy R, Walters R, Howe L, Kuchenbaecker K, Tyrrell J, et al (2021). HIGHER BMI CAUSES LOWER ODDS OF DEPRESSION IN INDIVIDUALS OF EAST ASIAN ANCESTRY.  Author URL.
Karageorgiou V, Casanova F, O'Loughlin J, Bowden J, Tyrrell J (2021). INFLAMMATION AND OVERWEIGHT AS PUTATIVE RISK FACTORS FOR DEPRESSION: a MULTIVARIABLE MENDELIAN RANDOMIZATION STUDY.  Author URL.
Gilchrist M, Casanova F, Tyrrell J, Fife N, Young K, Oram R, Weedon M (2021). MO042PREVALENCE OF FABRY DISEASE CAUSING VARIANTS IN THE UK BIOBANK.  Abstract.
Casanova F, Jones S, O'Loughlin J, Beaumont R, Wood A, Bowden J, Tyrrell J (2021). PHYSICAL ACTIVITY AND MENTAL HEALTH: a MENDELIAN RANDOMIZATION STUDY.  Author URL.
Gooding K, Chapman D, Casanova F, Ball C, Whatmore JL, Ling R, Shore AC (2019). A PRELIMINARY STUDY EXAMINING ALBUMINURIA, MACULAR THICKNESS AND GLYCOCALYX SHEDDING IN THE EARLY STAGES OF DIABETIC RETINOPATHY IN TYPE 2 DIABETES.  Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Khan F, Colhoun HM, Palombo C, et al (2019). ALTERED CENTRAL HAEMODYNAMIC PARAMETERS DERIVED FROM RESERVOIR PRESSURE ANALYSIS: ASSOCIATION WITH BIOMARKERS OF TARGET ORGAN DAMAGE IN OLDER ADULTS.  Author URL.
Gooding K, Casanova F, Cox D, Ball C, Aizawa K, Mawson D, Shore A (2019). Association Between Sural Nerve Conductance Amplitude and Skin Microvascular Responsiveness in Individuals with and without Type 2 Diabetes Across the Subclinical Neuropathy Range.  Author URL.
Meertens RM, Knapp KM, Casanova F, Ball SE, Strain WD (2019). Exploring the potential relationships between microvascular haemodynamics and density in bone: a feasibility study utilising near infrared spectroscopy. UKIO 2019. 10th - 12th Jun 2019.
Meakin PJ, Tuharska Z, Gooding KM, Casanova F, Shore AC, Ashford MLJ, Khan F (2018). Association between beta-amyloid, diabetes and endothelial function in humans.  Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Nilsson J, Khan F, Colhoun HM, et al (2018). PARAMETERS DERIVED FROM RESERVOIR PRESSURE ANALYSIS INDEPENDENTLY PREDICT CARDIOVASCULAR EVENTS IN a MULTI-CENTRE STUDY OF INDIVIDUALS WITH TYPE 2 DIABETES.  Author URL.
Ball C, Casanova F, Shore AC, Anning CM, Cox D, Gooding KM (2018). Participant feedback on strategies implemented to maintain participant engagement in a longitudinal, observational clinical study.  Author URL.
Casanova F, Adingupu DD, Gooding KM, Aizawa K, Gates PE, Elyas S, Shore AC, Strain DW (2017). Association Between Renal Function and Matrix Metalloproteinases in Type 2 Diabetes.  Author URL.
Gooding K, Shore AC, Casanova F, Colhoun HM, Looker HC, Leese GP, Agardh E (2017). EXAMINING LONGITUDINAL CHANGES OF MACULAR THICKNESS IN THE EARLY STAGES OF DIABETIC RETINOPATHY.  Author URL.
Gooding K, Mayne T, Casanova F, Ball C, Cox D, Ling R, Shore A (2017). Exploring the Relationship Between Retinal Micro-aneurysms with Plasma Levels of Matrix Metal-loproteinases and Growth Factors in Type 2 Diabetes.  Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Park CM, Elyas S, Adingupu DD, Strain WD, Parker KH, Gates PE, et al (2017). RESERVOIR-PRESSURE ANALYSIS PREDICTS CARDIOVASCULAR EVENTS IN INDIVIDUALS WITH TYPE 2 DIABETES: a SINGLE-CENTRE STUDY.  Author URL.
Meertens RM, Casanova F, Strain WD, Knapp K, Thorn C (2017). The use of near-infrared systems for investigations of microvascular haemodynamics in human in vivo bone tissue: a systematic review. International Society of Oxygen Transfer to Tissue Annual Meeting 2017. 19th - 23rd Aug 2017.
Meertens R, Knapp K, Strain D, Casanova F (2016). NEAR INFRARED SPECTROSCOPY: a POTENTIAL TOOL FOR ASSESSING HAEMODYNAMIC MARKERS OF THE MICROVASCULAR BLOOD SUPPLY WITHIN BONE TISSUE.  Author URL.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu DD, Gooding KM, Strain WD, Park CM, Parker KH, Gates PE, et al (2016). RESERVOIR-PRESSURE ANALYSIS IN TYPE 2 DIABETES INDIVIDUALS WITH CARDIOVASCULAR DISEASE.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The use of near infrared spectroscopy (NIRS) as a diagnostic tool to measure microvascular haemodynamics in bone tissue. National Osteoporosis Society 2016. 7th - 9th Nov 2016.
Casanova F, Adingupu D, Gooding K, Strain D, Shore A (2015). DOES GLYCAEMIC CONTROL AFFECT MICROVASCULAR FUNCTION INDEPENDENT OF BLOOD PRESSURE IN TYPE 2 DIABETES?.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson D, Shore AC, Strain WD, Gates PE (2015). PP.20.26.
Gooding KM, Shore AC, Ling R, Casanova F, Looker HC, Agardh E (2015). Regional differences in macular thickness in the early stages of diabetic retinopathy in type 2 diabetes.  Author URL.
Chapman DP, Gooding KM, McDonald TJ, Anning CM, Pamphilon N, Ball C, Casanova F, Shore AC (2015). Using clinical characteristics to account for variation of urinary creatinine excretion improves the accuracy of the albumin to creatinine ratio (ACR) to identify individuals with microalbuminuria.  Author URL.
Clark C, Casanova F, Gooding K, Pamphilon N, Aizawa K, Mawson D, Adingupu D, Ball C, Worthington F, Elyas S, et al (2014). Inter-arm blood pressure difference and differences in arterial stiffness.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson DM, Shore AC, Strain WD, Gates PE (2013). Carotid artery intima-media echogenicity and aortic stiffness in healthy middle-aged and older humans.  Author URL.

Publications by year


In Press

Frayling TM, Beaumont RN, Jones SE, Yaghootkar H, Tuke MA, Ruth KS, Casanova F, West B, Locke J, Sharp S, et al (In Press). A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure.  Abstract.
Casanova F, Gooding K, Shore A, Adingupu D, Mawson D, Ball C, Anning C, Aizawa K, Gates P, Strain W, et al (In Press). Weight change and sulphonylurea therapy are related to three-year change in microvascular function in people with type 2 diabetes. Diabetologia

2021

Hagenaars S, Casanova F, Gillett A, Green H, Lewis C, Tyrrell J (2021). ASSESSING THE IMPACT OF DEPRESSION DIAGNOSIS ON DIABETES AND LIFETIME HYPERGLYCAEMIA.  Author URL.
Elyas S, Adingupu D, Aizawa K, Casanova F, Gooding K, Fulford J, Mawson D, Gates PE, Shore AC, Strain D, et al (2021). Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets. Aging, 13(18), 22030-22039.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Khan F, Colhoun HM, Palombo C, et al (2021). ELEVATED EXCESS PRESSURE INTEGRAL IS ASSOCIATED WITH VASCULAR BIOMARKERS OF SUBCLINICAL ATHEROSCLEROSIS IN OLDER ADULTS.  Author URL.
O'Loughlin J, Casanova F, Hughes A, Bowden J, Watkins E, Freathy R, Walters R, Howe L, Kuchenbaecker K, Tyrrell J, et al (2021). HIGHER BMI CAUSES LOWER ODDS OF DEPRESSION IN INDIVIDUALS OF EAST ASIAN ANCESTRY.  Author URL.
Casanova F, O'Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins E, Freathy R, Hagenaars S, Frayling TM, Yaghootkar H, et al (2021). Higher adiposity and mental health: Causal inference using Mendelian randomisation. Hum Mol Genet Abstract.  Author URL.
Karageorgiou V, Casanova F, O'Loughlin J, Bowden J, Tyrrell J (2021). INFLAMMATION AND OVERWEIGHT AS PUTATIVE RISK FACTORS FOR DEPRESSION: a MULTIVARIABLE MENDELIAN RANDOMIZATION STUDY.  Author URL.
Meertens R, Knapp KM, Strain WD, Casanova F, Ball S, Fulford J, Thorn C (2021). In vivo Measurement of Intraosseous Vascular Haemodynamic Markers in Human Bone Tissue Utilising Near Infrared Spectroscopy. Frontiers in Physiology, 12 Abstract.
Gilchrist M, Casanova F, Tyrrell J, Fife N, Young K, Oram R, Weedon M (2021). MO042PREVALENCE OF FABRY DISEASE CAUSING VARIANTS IN THE UK BIOBANK.  Abstract.
Casanova F, Jones S, O'Loughlin J, Beaumont R, Wood A, Bowden J, Tyrrell J (2021). PHYSICAL ACTIVITY AND MENTAL HEALTH: a MENDELIAN RANDOMIZATION STUDY.  Author URL.
Aizawa K, Casanova F, Gates PE, Mawson DM, Gooding KM, Strain WD, Östling G, Nilsson J, Khan F, Colhoun HM, et al (2021). Reservoir-Excess Pressure Parameters Independently Predict Cardiovascular Events in Individuals with Type 2 Diabetes. Hypertension, 78(1), 40-50. Abstract.
Cresswell M, Casanova F, Beaumont RN, Wood AR, Ronan N, Hilton MP, Tyrrell J (2021). Understanding Factors That Cause Tinnitus: a Mendelian Randomization Study in the UK Biobank. Ear Hear Abstract.  Author URL.
O'Loughlin J, Casanova F, Jones SE, Hagenaars SP, Beaumont RN, Freathy RM, Watkins ER, Vetter C, Rutter MK, Cain SW, et al (2021). Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health. Mol Psychiatry Abstract.  Author URL.

2020

Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract.  Author URL.
Aizawa K, Casanova F, Mawson D, Gooding K, Elyas S, Adingupu D, Strain D, Gates P, Shore A (2020). P17 Comparisons of Carotid-femoral Pulse Wave Velocity Obtained from the Surface-distance Measurement and from the Population-derived Distance Formula: Associations with Macro- and Microvascular Alterations in Older Adults. Artery Research, 25(Supplement 1).

2019

Gooding K, Chapman D, Casanova F, Ball C, Whatmore JL, Ling R, Shore AC (2019). A PRELIMINARY STUDY EXAMINING ALBUMINURIA, MACULAR THICKNESS AND GLYCOCALYX SHEDDING IN THE EARLY STAGES OF DIABETIC RETINOPATHY IN TYPE 2 DIABETES.  Author URL.
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract.  Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Khan F, Colhoun HM, Palombo C, et al (2019). ALTERED CENTRAL HAEMODYNAMIC PARAMETERS DERIVED FROM RESERVOIR PRESSURE ANALYSIS: ASSOCIATION WITH BIOMARKERS OF TARGET ORGAN DAMAGE IN OLDER ADULTS.  Author URL.
Aizawa K, Ramalli A, Sbragi S, Tortoli P, Casanova F, Morizzo C, Thorn CE, Shore AC, Gates PE, Palombo C, et al (2019). Arterial wall shear rate response to reactive hyperaemia is markedly different between young and older humans. J Physiol, 597(16), 4151-4163. Abstract.  Author URL.
Gooding K, Casanova F, Cox D, Ball C, Aizawa K, Mawson D, Shore A (2019). Association Between Sural Nerve Conductance Amplitude and Skin Microvascular Responsiveness in Individuals with and without Type 2 Diabetes Across the Subclinical Neuropathy Range.  Author URL.
Meertens RM, Knapp KM, Casanova F, Ball SE, Strain WD (2019). Exploring the potential relationships between microvascular haemodynamics and density in bone: a feasibility study utilising near infrared spectroscopy. UKIO 2019. 10th - 12th Jun 2019.
Meertens RM, Knapp KM, Casanova F, Ball SE, Strain WD (2019). The reproducibility of near infrared spectroscopy markers of microvascular haemodynamics at the proximal tibia and gastrocnemius.

2018

Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.
van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, et al (2018). A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects with Type 2 Diabetes. Diabetes, 67(7), 1414-1427. Abstract.  Author URL.
Meakin PJ, Tuharska Z, Gooding KM, Casanova F, Shore AC, Ashford MLJ, Khan F (2018). Association between beta-amyloid, diabetes and endothelial function in humans.  Author URL.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn CE, Shore AC, Gates PE, Palombo C, et al (2018). Brachial artery vasodilatory response and wall shear rate determined by multigate Doppler in a healthy young cohort. J Appl Physiol (1985), 124(1), 150-159. Abstract.  Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Nilsson J, Khan F, Colhoun HM, et al (2018). PARAMETERS DERIVED FROM RESERVOIR PRESSURE ANALYSIS INDEPENDENTLY PREDICT CARDIOVASCULAR EVENTS IN a MULTI-CENTRE STUDY OF INDIVIDUALS WITH TYPE 2 DIABETES.  Author URL.
Ball C, Casanova F, Shore AC, Anning CM, Cox D, Gooding KM (2018). Participant feedback on strategies implemented to maintain participant engagement in a longitudinal, observational clinical study.  Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Östling G, Khan F, Colhoun HM, Palombo C, et al (2018). Reservoir pressure integral is independently associated with the reduction in renal function in an older population. Artery Research, 24(C), 72-73.
Meertens RM, Casanova F, Knapp KM, Thorn C, Strain WD (2018). Use of Near-Infrared Systems for Investigations of Hemodynamics in Human in Vivo Bone Tissue: a Systematic Review. Journal of Orthopaedic Research
Shore AC, Colhoun HM, Natali A, Palombo C, Khan F, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, et al (2018). Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: the SUMMIT VIP Study. Diabetes Care, 41(10), 2212-2219. Abstract.  Author URL.

2017

Casanova F, Adingupu DD, Gooding KM, Aizawa K, Gates PE, Elyas S, Shore AC, Strain DW (2017). Association Between Renal Function and Matrix Metalloproteinases in Type 2 Diabetes.  Author URL.
Gooding K, Shore AC, Casanova F, Colhoun HM, Looker HC, Leese GP, Agardh E (2017). EXAMINING LONGITUDINAL CHANGES OF MACULAR THICKNESS IN THE EARLY STAGES OF DIABETIC RETINOPATHY.  Author URL.
Gooding K, Mayne T, Casanova F, Ball C, Cox D, Ling R, Shore A (2017). Exploring the Relationship Between Retinal Micro-aneurysms with Plasma Levels of Matrix Metal-loproteinases and Growth Factors in Type 2 Diabetes.  Author URL.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn C, Shore A, Gates P, Palombo C, et al (2017). Influence of brachial artery stiffness on flow-mediated dilatation in healthy young and older populations. Artery Research, 20(C).
Aizawa K, Casanova F, Mawson DM, Gooding KM, Park CM, Elyas S, Adingupu DD, Strain WD, Parker KH, Gates PE, et al (2017). RESERVOIR-PRESSURE ANALYSIS PREDICTS CARDIOVASCULAR EVENTS IN INDIVIDUALS WITH TYPE 2 DIABETES: a SINGLE-CENTRE STUDY.  Author URL.
Casanova F, Adingupu DD, Adams F, Gooding KM, Looker HC, Aizawa K, Dove F, Elyas S, Belch JJF, Gates PE, et al (2017). The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control. Cardiovasc Diabetol, 16(1). Abstract.  Author URL.
Meertens RM, Casanova F, Strain WD, Knapp K, Thorn C (2017). The use of near-infrared systems for investigations of microvascular haemodynamics in human in vivo bone tissue: a systematic review. International Society of Oxygen Transfer to Tissue Annual Meeting 2017. 19th - 23rd Aug 2017.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn C, Shore A, Gates P, Palombo C, et al (2017). Wall shear rate and brachial artery flow-mediated dilatory response between healthy young and older populations using multi-gate spectral Doppler ultrasound. Artery Research, 20(C).

2016

Gonçalves I, Edsfeldt A, Colhoun HM, Shore AC, Palombo C, Natali A, Fredrikson GN, Björkbacka H, Wigren M, Bengtsson E, et al (2016). Association between renin and atherosclerotic burden in subjects with and without type 2 diabetes. BMC Cardiovasc Disord, 16(1). Abstract.  Author URL.
Aizawa K, Sbragi S, Ramalli A, Tortoli P, Casanova F, Morizzo C, Thorn C, Shore A, Gates P, Palombo C, et al (2016). Brachial artery flow-mediated dilatation: different patterns of wall shear rate increase during reactive hyperaemia. Artery Research, 16(C), 67-68.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE (2016). Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Ultrasound Med Biol, 42(5), 1130-1137. Abstract.  Author URL.
Meertens R, Knapp K, Strain D, Casanova F (2016). NEAR INFRARED SPECTROSCOPY: a POTENTIAL TOOL FOR ASSESSING HAEMODYNAMIC MARKERS OF THE MICROVASCULAR BLOOD SUPPLY WITHIN BONE TISSUE.  Author URL.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu DD, Gooding KM, Strain WD, Park CM, Parker KH, Gates PE, et al (2016). RESERVOIR-PRESSURE ANALYSIS IN TYPE 2 DIABETES INDIVIDUALS WITH CARDIOVASCULAR DISEASE.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE (2016). Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Physiol Rep, 4(12). Abstract.  Author URL.
Bokori-Brown M, Petrov PG, Khafaji MA, Mughal MK, Naylor CE, Shore AC, Gooding KM, Casanova F, Mitchell TJ, Titball RW, et al (2016). Red Blood Cell Susceptibility to Pneumolysin: CORRELATION WITH MEMBRANE BIOCHEMICAL AND PHYSICAL PROPERTIES. J Biol Chem, 291(19), 10210-10227. Abstract.  Author URL.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The Effects of Lumbar Sympathectomy on Bone and Soft Tissue Haemodynamics of the Leg recorded using Near Infrared Spectroscopy: a Case Report. Journal of Biomedical Engineering and Informatics, 3, 28-32.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The use of near infrared spectroscopy (NIRS) as a diagnostic tool to measure microvascular haemodynamics in bone tissue. National Osteoporosis Society 2016. 7th - 9th Nov 2016.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu DD, Gooding KM, Strain WD, Park CM, Parker KH, Gates PE, et al (2016). [PP.11.05] RESERVOIR-PRESSURE ANALYSIS IN TYPE 2 DIABETES INDIVIDUALS WITH CARDIOVASCULAR DISEASE. Journal of Hypertension, 34(Supplement 2), e178-e178.

2015

Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW, et al (2015). Blood Oxygen Saturation After Ischemia is Altered with Abnormal Microvascular Reperfusion. Microcirculation, 22(4), 294-305. Abstract.  Author URL.
Casanova F, Adingupu D, Gooding K, Strain D, Shore A (2015). DOES GLYCAEMIC CONTROL AFFECT MICROVASCULAR FUNCTION INDEPENDENT OF BLOOD PRESSURE IN TYPE 2 DIABETES?.  Author URL.
Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, et al (2015). Elevated Plasma Levels of MMP-12 Are Associated with Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects with Type 2 Diabetes. Arterioscler Thromb Vasc Biol, 35(7), 1723-1731. Abstract.  Author URL.
Shore AC, Colhoun HM, Natali A, Palombo C, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, et al (2015). Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study. Journal of Internal Medicine, 278(3), 291-302. Abstract.
Shore AC, Colhoun HM, Natali A, Palombo C, Östling G, Aizawa K, Kennbäck C, Casanova F, Persson M, Gooding K, et al (2015). Measures of atherosclerotic burden are associated with clinically manifest cardiovascular disease in type 2 diabetes: a European cross-sectional study. J Intern Med, 278(3), 291-302. Abstract.  Author URL.
Aizawa. K, Casanova F, Mawson D, Elyas S, Adingupu D, Gooding K, Strain D, Shore A, Gates P (2015). P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS. Artery Research, 12(C), 11-11.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson D, Shore AC, Strain WD, Gates PE (2015). PP.20.26.
Gooding KM, Shore AC, Ling R, Casanova F, Looker HC, Agardh E (2015). Regional differences in macular thickness in the early stages of diabetic retinopathy in type 2 diabetes.  Author URL.
Chapman DP, Gooding KM, McDonald TJ, Anning CM, Pamphilon N, Ball C, Casanova F, Shore AC (2015). Using clinical characteristics to account for variation of urinary creatinine excretion improves the accuracy of the albumin to creatinine ratio (ACR) to identify individuals with microalbuminuria.  Author URL.

2014

Clark C, Casanova F, Gooding K, Pamphilon N, Aizawa K, Mawson D, Adingupu D, Ball C, Worthington F, Elyas S, et al (2014). Inter-arm blood pressure difference and differences in arterial stiffness.  Author URL.

2013

Cooney JK, Moore JP, Ahmad YA, Jones JG, Lemmey AB, Casanova F, Maddison PJ, Thom JM (2013). A simple step test to estimate cardio-respiratory fitness levels of rheumatoid arthritis patients in a clinical setting. Int J Rheumatol, 2013 Abstract.  Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson DM, Shore AC, Strain WD, Gates PE (2013). Carotid artery intima-media echogenicity and aortic stiffness in healthy middle-aged and older humans.  Author URL.
Lemmey Andrew B. Elamanchi Srinivasa Rao , Marcora. Samuele M. Casanova Francesco and Maddison Peter J. (2013). Efficacy of Nandrolone Decanoate in Treating Rheumatoid Cachexia in Male Rheumatoid Arthritis Patients, Innovative Rheumatology.  Author URL.
Adingupu DD, Elyas S, Casanova F, Gates PE, Shore AC, Strain WD (2013). Microvascular autoregulatory response to ischaemia and pulse pressure. JOURNAL OF HUMAN HYPERTENSION, 27(10), 652-653. Author URL.
Adingupu DD, Thorn C, Casanova F, Elyas S, Gates PE, Strain WD, Shore AC (2013). Microvascular autoregulatory response to ischaemia in the skin and association with mean blood oxygen saturation. JOURNAL OF HUMAN HYPERTENSION, 27(10), 640-641. Author URL.

2009

Lemmey AB, Marcora SM, Chester K, Wilson S, Casanova F, Maddison PJ (2009). Effects of high-intensity resistance training in patients with rheumatoid arthritis: a randomized controlled trial. Arthritis Rheum, 61(12), 1726-1734. Abstract.  Author URL.

2007

Marcora SM, Casanova F, Fortes MB, Maddison PJ (2007). Validity and reliability of the Siconolfi Step Test for assessment of physical fitness in patients with systemic lupus erythematosus. Arthritis Rheum, 57(6), 1007-1011. Abstract.  Author URL.

2006

Marcora S, Casanova F, Williams E, Jones J, Elamanchi R, Lemmey A (2006). Preliminary evidence for cachexia in patients with well-established ankylosing spondylitis. RHEUMATOLOGY, 45(11), 1385-1388. Author URL.
Marcora S, Casanova F, Williams E, Jones J, Elamanchi R, Lemmey A (2006). Preliminary evidence for cachexia in patients with well-established ankylosing spondylitis. Rheumatology (Oxford), 45(11), 1385-1388. Abstract.  Author URL.
Fortes MB, Casanova F, Marcora S (2006). Reliability and Validity of the Siconolfi Step-Test in Patients with Systemic Lupus Erythematosus. Medicine & Science in Sports & Exercise, 38(Supplement).

2005

La Torre A, Impellizzeri FM, Rampinini E, Casanova F, Alberti G, Marcora SM (2005). Cardiovascular responses to aerobic step dance sessions with and without appendicular overload. J Sports Med Phys Fitness, 45(3), 264-269. Abstract.  Author URL.

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