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 Emma Dempster

Emma Dempster

Lecturer

01392 408264

RILD Building 

My main current research focus is on epigenetic changes observed in twins discordant for disease, I am currently collating one of the largest cohorts of schizophrenia discordant twins in epigenetic research. My other research interests include the effects of CNVs on DNA methlyation patterns,  how THC exposure influences DNA methylation  and profiling other epigenetic modifications.

 

Qualifications

I graduated with an honors degree in Genetics from Cardiff University in 1998 and subsequently spent two years in industry. In 2000 I was awarded an MRC predoctoral studentship to undertake a PhD at the Institute of Psychiatry, King’s College London (KCL) where I focused on identifying genetic variation associated with schizophrenia.

Career

 After completing my PhD I moved to Canada where I was awarded a University of Toronto Postdoctoral Fellowship to examine functional variation in genes related to stress in the aetiology of depression. Family circumstances brought me back to the UK where I joined  Dr Mill’s psychiatric epigenetics group in KCL and then subsequently relocated with Professor Mill to the Univeristy of Exeter in 2012.

Links

Research

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.  Full text.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract.  Author URL.  Full text.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.  Full text.
Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.  Full text.
Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1).
Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract.  Author URL.  Full text.
Unternaehrer E, Bolten M, Nast I, Staehli S, Meyer AH, Dempster E, Hellhammer DH, Lieb R, Meinlschmidt G (2016). Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation. Soc Cogn Affect Neurosci, 11(9), 1460-1470. Abstract.  Author URL.
Kumsta R, Marzi SJ, Viana J, Dempster EL, Crawford B, Rutter M, Mill J, Sonuga-Barke EJS (2016). Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry, 6(6). Abstract.  Author URL.  Full text.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.
Unternaehrer E, Meyer AH, Burkhardt SCA, Dempster E, Staehli S, Theill N, Lieb R, Meinlschmidt G (2015). Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress, 18(4), 451-461. Abstract.  Author URL.
Wong CCY, Parsons MJ, Lester KJ, Burrage J, Eley TC, Mill J, Dempster EL, Gregory AM (2015). Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference. Twin Res Hum Genet, 18(6), 662-669. Abstract.  Author URL.  Full text.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.
Fisher H, Murphy T, Arseneault L, Burrage J, Dempster E, Caspi A, Moffitt T, Mill J (2014). Genome-wide DNA methylation profiling in monozygotic twins discordant for psychotic symptoms at age 12. EARLY INTERVENTION IN PSYCHIATRY, 8, 57-57. Author URL.
Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biological Psychiatry, 76(12), 977-983. Abstract.
Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biol Psychiatry, 76(12), 977-983. Abstract.  Author URL.  Full text.
Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL.
Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS One, 9(2). Abstract.  Author URL.  Full text.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Translational Psychiatry, 4(9), e455-e455.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry, 4 Abstract.  Author URL.
Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MADS, Huston JP, Mill J, Müller CP, et al (2013). Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addict Biol, 18(3), 452-454. Abstract.  Author URL.
Dempster E, Viana J, Pidsley R, Mill J (2013). Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future. Schizophr Bull, 39(1), 11-16. Abstract.  Author URL.
Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, Campbell IC, Schmidt U (2013). Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study. J Psychiatr Res, 47(2), 280-282. Author URL.
Xie W, Barr CL, Kim A, Yue F, Lee AY, Eubanks J, Dempster EL, Ren B (2012). Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome. CELL, 148(4), 816-831. Author URL.
Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, Lieb R, Hellhammer DH, Meinlschmidt G (2012). Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. TRANSLATIONAL PSYCHIATRY, 2 Author URL.
Pidsley R, Dempster E, Troakes C, Al-Sarraj S, Mill J (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight. Epigenetics, 7(2), 155-163. Abstract.  Author URL.
Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al (2012). Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population. PLOS GENETICS, 8(4), 189-200. Author URL.
Mizuno K, Dempster E, Mill J, Giese KP (2012). Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes Brain Behav, 11(6), 651-659. Abstract.  Author URL.
Kember RL, Dempster EL, Lee THA, Schalkwyk LC, Mill J, Fernandes C (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. BRAIN AND BEHAVIOR, 2(4), 455-467. Author URL.
Clarke T-K, Dempster E, Docherty SJ, Desrivieres S, Lourdsamy A, Wodarz N, Ridinger M, Maier W, Rietschel M, Schumann G, et al (2012). Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse. Addict Biol, 17(1), 202-208. Abstract.  Author URL.
Cannon DM, Walshe M, Dempster E, Collier DA, Marshall N, Bramon E, Murray RM, McDonald C (2012). The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives. TRANSLATIONAL PSYCHIATRY, 2 Author URL.
Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, et al (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet, 20(24), 4786-4796. Abstract.  Author URL.
Ingason A, Kirov G, Giegling I, Hansen T, Isles AR (2011). Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry, 168(4), 408-417. Abstract.
Bergen SE, Balhara YPS, Christoforou A, Cole J, Degenhardt F, Dempster E, Fatjo-Vilas M, Khedr Y, Lopez LM, Lysenko L, et al (2011). Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3-7 October 2010. PSYCHIATRIC GENETICS, 21(3), 136-172. Author URL.
Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract.  Author URL.
Pidsley R, Dempster EL, Mill J (2010). Brain weight in males is correlated with DNA methylation at IGF2. MOLECULAR PSYCHIATRY, 15(9), 880-881. Author URL.
Strauss JS, Freeman NL, Shaikh SA, Vetro A, Kiss E, Kapornai K, Daroczi G, Rimay T, Kothencne VO, Dombovari E, et al (2010). No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. PSYCHONEUROENDOCRINOLOGY, 35(9), 1422-1428. Author URL.
Dempster EL, Kiss E, Kapornai K, Daróczi G, Mayer L, Baji I, Tamas Z, Gadoros J, Kennedy JL, Vetró A, et al (2010). No evidence of an association between two genes, EDN1 and ACE, and childhood-onset mood disorders. Am J Med Genet B Neuropsychiatr Genet, 153B(1), 341-346. Abstract.  Author URL.
Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamas Z, Kapornai K, Daroczy G, Kennedy JL, et al (2009). Further genetic evidence implicates the vasopressin system in childhood-onset mood disorders. EUROPEAN JOURNAL OF NEUROSCIENCE, 30(8), 1615-1619. Author URL.
Dutt A, McDonald C, Dempster E, Prata D, Shaikh M, Williams I, Schulze K, Marshall N, Walshe M, Allin M, et al (2009). The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis. Psychol Med, 39(11), 1783-1797. Abstract.  Author URL.
Bramon E, Dempster E, Frangou S, Shaikh M, Walshe M, Filbey FM, McDonald C, Sham P, Collier DA, Murray R, et al (2008). Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype. Schizophr Res, 103(1-3), 178-185. Abstract.  Author URL.
Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamás Z, Kennedy JL, Vetró A, Kovacs M, et al (2007). Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. Arch Gen Psychiatry, 64(10), 1189-1195. Abstract.  Author URL.
Dempster EL, Kiss E, Kapornai K, Daroczy G, Mayer L, Baji I, Tamas Z, Gadoros J, Kennedy JL, Vetro A, et al (2007). No evidence of association between a functional polymorphism in the MTHFR gene and childhood-onset mood disorders. MOLECULAR PSYCHIATRY, 12(12), 1063-1064. Author URL.
Mill J, Dempster E, Caspi A, Williams B, Moffitt T, Craig I (2006). Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet, 141B(4), 421-425. Abstract.  Author URL.
Bramon E, Dempster E, Frangou S, McDonald C, Schoenberg P, MacCabe JH, Walshe M, Sham P, Collier D, Murray RM, et al (2006). Is there an association between the COMT gene and P300 endophenotypes?. Eur Psychiatry, 21(1), 70-73. Abstract.  Author URL.
Fernandes C, Hoyle E, Dempster E, Schalkwyk LC, Collier DA (2006). Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav, 5(6), 433-440. Abstract.  Author URL.
Dempster EL, Mill J, Craig IW, Collier DA (2006). The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. BMC Med Genet, 7 Abstract.  Author URL.
Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F, Wickham H, Sham PC, Murray RM, Collier DA, et al (2005). Association between BDNF val66 met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet, 134B(1), 73-75. Abstract.  Author URL.
Dempster EL, Li T, Ashworth A, Liu X, St Clair D, Breen G, Collier D (2001). Reelin as a candidate gene for schizophrenia. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 624-625. Author URL.
Dempster EL, Pryor KV, Francis D, Young JE, Rogers HJ (1999). Rapid DNA extraction from ferns for PCR-based analyses. BioTechniques, 27(1), 66-68.

Conferences

Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA.  Author URL.
Mizuno K, Dempster E, Mill J, Giese KP (2013). Long-lasting regulation of hippocampal brain-derived neurotrophic factor gene transcription after contextual fear conditioning.  Author URL.
Boks MP, Pidsley R, van Eijk K, Dempster EL, Bank NB, de Jong S, Pol HEH, van Haren NE, Murray R, Kahn RS, et al (2012). MONOZYGOTIC TWINS DISCORDANT FOR BIPOLAR DISORDER SHOW FUNCTIONAL DNA METHYLATION CHANGES IN WHOLE BLOOD AND BRAIN.  Author URL.
Boks MPM, Pidsley R, van Eijk K, Dempster EL, de Jong S, Schalkwijk L, Hulshof-Poll HE, van Haren NEM, Murray R, Kahn RS, et al (2012). Monozygotic twins discordant for bipolar disorder show functional DNA methylation changes in whole blood and brain.  Author URL.
Dutt A, McDonald C, Shaikh M, Dempster E, Prata D, Williama I, Schulze K, Marshall N, Walshe M, Allin M, et al (2010). DOES THE DYSBINDIN GENE INFLUENCE HIPPOCAMPAL VOLUME IN PSYCHOSIS?.  Author URL.
Alkelai A, Baum A, Carless M, Crowley J, DasBanerjee T, Dempster E, Docherty S, Hare E, Galsworthy MJ, Grover D, et al (2008). The XVth World Congress of Psychiatric Genetics, October 7-11, 2007: Rapporteur summaries of oral presentations.  Abstract.
Dempster EL, Toulopoulou T, McDonald C, Bramon E, Walshe M, Wickham H, Sham PC, Murray RM, Collier DA (2006). Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.  Author URL.
Dempster E, Burcescu I, Wigg K, Kiss E, Baji I, Vetro A, Kennedy J, Marika K, Barr C (2006). Investigation of the genes encoding arginine vasopressin (AVP) and its receptor (AVPR1B) in childhood-onset mood disorder.  Author URL.
Dempster EL, Wigg KG, Vetro A, Kiss E, Kaponai K, Mayer L, Gadoros J, Kennedy J, Kovacs M, Barr CL, et al (2006). Investigation of the genes encoding substance P (TAC1) and its receptor (TACR1) in childhood-onset depression.  Author URL.
Reynolds GP, Piyabhan P, Nudmamud-Thanoi S, Dempster E, Collier DA (2006). Neuregulin polymorphism associates with indicators of Glutamatergic synaptic function in human post-mortem striatium.  Author URL.
Bramon E, Dempster E, Frangou S, Walshe M, McDonald C, Sham P, Collier D, Murray R (2006). Neuregulin-1 is associated with slower cognitive processing in schizophrenia.  Author URL.
McDonald C, Bullmore ET, Dempster E, Chitnis XA, Sham PC, Collier DA, Murray RM (2005). Association between brain structural endophenotypes of psychotic disorders and genotypic variation.  Author URL.
Dempster EL, Mill J, Craig IW, Collier DA (2005). Does COMT promoter methylation regulate gene expression?.  Author URL.
Bramon E, Dempster E, Shaikh M, McDonald C, Walshe M, MacCabe J, Frangou S, Collier D, Murray R (2005). Genetic influences on brain physiology in schizophrenia.  Author URL.
Mill J, Caspi A, Dempster EL, Williams BS, Moffitt TE, Craig I (2005). Methylation analysis of a NGF1-A transcription factor binding-site in the promoter region of the human glucocorticoid receptor gene (NR3C1).  Author URL.
McDonald C, Bullmore ET, Chitnis X, Dempster E, Sham P, Collier D, Murray R (2004). Brain structural endophenotypes of psychotic disorders and their association with genotypic variation.  Author URL.
Dempster EL, Mill JS, Murray R, Collier DA (2004). Expression analysis of five schizophrenia candidate genes in post-mortem cerebellum samples using quantitative real time RT-PCR.  Author URL.
Dempster EL, Toulopoulou T, Wickham H, Bramon E, McDonald C, Sham P, Murray R, Collier D (2004). The presence of a 2BP deletion in exon 6 of the 'alpha 7-like' nicotinic receptor subunit gene predicts worse performance in an episodic memory.  Author URL.
Dempster EL, Li T, Ashworth A, Liu X, Collier DA (2003). Reelin as a candidate gene for schizophrenia.  Author URL.

Publications by year


2017

Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA.  Author URL.
Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract.  Author URL.  Full text.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract.  Author URL.  Full text.

2016

Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract.  Author URL.  Full text.
Laing LV, Viana J, Dempster EL, Trznadel M, Trunkfield LA, Uren Webster TM, van Aerle R, Paull GC, Wilson RJ, Mill J, et al (2016). Bisphenol a causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio). Epigenetics, 11(7), 526-538. Abstract.  Author URL.  Full text.
Jeffries AR, Uwanogho DA, Cocks G, Perfect LW, Dempster E, Mill J, Price J (2016). Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming. RNA, 22(10), 1620-1630. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, G Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1).
Cizmeci D, Dempster EL, Champion OL, Wagley S, Akman OE, Prior JL, Soyer OS, Mill J, Titball RW (2016). Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection. Sci Rep, 6 Abstract.  Author URL.  Full text.
Unternaehrer E, Bolten M, Nast I, Staehli S, Meyer AH, Dempster E, Hellhammer DH, Lieb R, Meinlschmidt G (2016). Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation. Soc Cogn Affect Neurosci, 11(9), 1460-1470. Abstract.  Author URL.
Kumsta R, Marzi SJ, Viana J, Dempster EL, Crawford B, Rutter M, Mill J, Sonuga-Barke EJS (2016). Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1. Transl Psychiatry, 6(6). Abstract.  Author URL.  Full text.
Marzi SJ, Meaburn EL, Dempster EL, Lunnon K, Paya-Cano JL, Smith RG, Volta M, Troakes C, Schalkwyk LC, Mill J, et al (2016). Tissue-specific patterns of allelically-skewed DNA methylation. Epigenetics, 11(1), 24-35. Abstract.  Author URL.  Full text.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract.  Author URL.  Full text.

2015

Unternaehrer E, Meyer AH, Burkhardt SCA, Dempster E, Staehli S, Theill N, Lieb R, Meinlschmidt G (2015). Childhood maternal care is associated with DNA methylation of the genes for brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) in peripheral blood cells in adult men and women. Stress, 18(4), 451-461. Abstract.  Author URL.
Wong CCY, Parsons MJ, Lester KJ, Burrage J, Eley TC, Mill J, Dempster EL, Gregory AM (2015). Epigenome-Wide DNA Methylation Analysis of Monozygotic Twins Discordant for Diurnal Preference. Twin Res Hum Genet, 18(6), 662-669. Abstract.  Author URL.  Full text.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract.  Author URL.  Full text.

2014

Fisher H, Murphy T, Arseneault L, Burrage J, Dempster E, Caspi A, Moffitt T, Mill J (2014). Genome-wide DNA methylation profiling in monozygotic twins discordant for psychotic symptoms at age 12. EARLY INTERVENTION IN PSYCHIATRY, 8, 57-57. Author URL.
Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biological Psychiatry, 76(12), 977-983. Abstract.
Dempster EL, Wong CCY, Lester KJ, Burrage J, Gregory AM, Mill J, Eley TC (2014). Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Biol Psychiatry, 76(12), 977-983. Abstract.  Author URL.  Full text.
Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai P-C, Collier DA, et al (2014). Hypermethylation in the ZBTB20 gene is associated with major depressive disorder. GENOME BIOLOGY, 15(4). Author URL.
Ilott NE, Schneider T, Mill J, Schalkwyk L, Brolese G, Bizarro L, Stolerman IP, Dempster E, Asherson P (2014). Long-term effects of gestational nicotine exposure and food-restriction on gene expression in the striatum of adolescent rats. PLoS One, 9(2). Abstract.  Author URL.  Full text.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Translational Psychiatry, 4(9), e455-e455.
Basil P, Li Q, Dempster EL, Mill J, Sham P-C, Wong CCY, McAlonan GM (2014). Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain. Transl Psychiatry, 4 Abstract.  Author URL.

2013

Barros M, Dempster EL, Illott N, Chabrawi S, Maior RS, Tomaz C, Silva MADS, Huston JP, Mill J, Müller CP, et al (2013). Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. Addict Biol, 18(3), 452-454. Abstract.  Author URL.
Dempster E, Viana J, Pidsley R, Mill J (2013). Epigenetic studies of schizophrenia: progress, predicaments, and promises for the future. Schizophr Bull, 39(1), 11-16. Abstract.  Author URL.
Mizuno K, Dempster E, Mill J, Giese KP (2013). Long-lasting regulation of hippocampal brain-derived neurotrophic factor gene transcription after contextual fear conditioning.  Author URL.
Pjetri E, Dempster E, Collier DA, Treasure J, Kas MJ, Mill J, Campbell IC, Schmidt U (2013). Quantitative promoter DNA methylation analysis of four candidate genes in anorexia nervosa: a pilot study. J Psychiatr Res, 47(2), 280-282. Author URL.

2012

Xie W, Barr CL, Kim A, Yue F, Lee AY, Eubanks J, Dempster EL, Ren B (2012). Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome. CELL, 148(4), 816-831. Author URL.
Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, Lieb R, Hellhammer DH, Meinlschmidt G (2012). Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. TRANSLATIONAL PSYCHIATRY, 2 Author URL.
Pidsley R, Dempster E, Troakes C, Al-Sarraj S, Mill J (2012). Epigenetic and genetic variation at the IGF2/H19 imprinting control region on 11p15.5 is associated with cerebellum weight. Epigenetics, 7(2), 155-163. Abstract.  Author URL.
Bell JT, Tsai P-C, Yang T-P, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al (2012). Epigenome-Wide Scans Identify Differentially Methylated Regions for Age and Age-Related Phenotypes in a Healthy Ageing Population. PLOS GENETICS, 8(4), 189-200. Author URL.
Mizuno K, Dempster E, Mill J, Giese KP (2012). Long-lasting regulation of hippocampal Bdnf gene transcription after contextual fear conditioning. Genes Brain Behav, 11(6), 651-659. Abstract.  Author URL.
Boks MP, Pidsley R, van Eijk K, Dempster EL, Bank NB, de Jong S, Pol HEH, van Haren NE, Murray R, Kahn RS, et al (2012). MONOZYGOTIC TWINS DISCORDANT FOR BIPOLAR DISORDER SHOW FUNCTIONAL DNA METHYLATION CHANGES IN WHOLE BLOOD AND BRAIN.  Author URL.
Kember RL, Dempster EL, Lee THA, Schalkwyk LC, Mill J, Fernandes C (2012). Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse. BRAIN AND BEHAVIOR, 2(4), 455-467. Author URL.
Boks MPM, Pidsley R, van Eijk K, Dempster EL, de Jong S, Schalkwijk L, Hulshof-Poll HE, van Haren NEM, Murray R, Kahn RS, et al (2012). Monozygotic twins discordant for bipolar disorder show functional DNA methylation changes in whole blood and brain.  Author URL.
Clarke T-K, Dempster E, Docherty SJ, Desrivieres S, Lourdsamy A, Wodarz N, Ridinger M, Maier W, Rietschel M, Schumann G, et al (2012). Multiple polymorphisms in genes of the adrenergic stress system confer vulnerability to alcohol abuse. Addict Biol, 17(1), 202-208. Abstract.  Author URL.
Cannon DM, Walshe M, Dempster E, Collier DA, Marshall N, Bramon E, Murray RM, McDonald C (2012). The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives. TRANSLATIONAL PSYCHIATRY, 2 Author URL.

2011

Dempster EL, Pidsley R, Schalkwyk LC, Owens S, Georgiades A, Kane F, Kalidindi S, Picchioni M, Kravariti E, Toulopoulou T, et al (2011). Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder. Hum Mol Genet, 20(24), 4786-4796. Abstract.  Author URL.
Ingason A, Kirov G, Giegling I, Hansen T, Isles AR (2011). Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illness. American Journal of Psychiatry, 168(4), 408-417. Abstract.
Bergen SE, Balhara YPS, Christoforou A, Cole J, Degenhardt F, Dempster E, Fatjo-Vilas M, Khedr Y, Lopez LM, Lysenko L, et al (2011). Summaries from the XVIII World Congress of Psychiatric Genetics, Athens, Greece, 3-7 October 2010. PSYCHIATRIC GENETICS, 21(3), 136-172. Author URL.

2010

Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J (2010). Allelic skewing of DNA methylation is widespread across the genome. Am J Hum Genet, 86(2), 196-212. Abstract.  Author URL.
Pidsley R, Dempster EL, Mill J (2010). Brain weight in males is correlated with DNA methylation at IGF2. MOLECULAR PSYCHIATRY, 15(9), 880-881. Author URL.
Dutt A, McDonald C, Shaikh M, Dempster E, Prata D, Williama I, Schulze K, Marshall N, Walshe M, Allin M, et al (2010). DOES THE DYSBINDIN GENE INFLUENCE HIPPOCAMPAL VOLUME IN PSYCHOSIS?.  Author URL.
Strauss JS, Freeman NL, Shaikh SA, Vetro A, Kiss E, Kapornai K, Daroczi G, Rimay T, Kothencne VO, Dombovari E, et al (2010). No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. PSYCHONEUROENDOCRINOLOGY, 35(9), 1422-1428. Author URL.
Dempster EL, Kiss E, Kapornai K, Daróczi G, Mayer L, Baji I, Tamas Z, Gadoros J, Kennedy JL, Vetró A, et al (2010). No evidence of an association between two genes, EDN1 and ACE, and childhood-onset mood disorders. Am J Med Genet B Neuropsychiatr Genet, 153B(1), 341-346. Abstract.  Author URL.

2009

Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamas Z, Kapornai K, Daroczy G, Kennedy JL, et al (2009). Further genetic evidence implicates the vasopressin system in childhood-onset mood disorders. EUROPEAN JOURNAL OF NEUROSCIENCE, 30(8), 1615-1619. Author URL.
Dutt A, McDonald C, Dempster E, Prata D, Shaikh M, Williams I, Schulze K, Marshall N, Walshe M, Allin M, et al (2009). The effect of COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes on hippocampal and lateral ventricular volume in psychosis. Psychol Med, 39(11), 1783-1797. Abstract.  Author URL.

2008

Bramon E, Dempster E, Frangou S, Shaikh M, Walshe M, Filbey FM, McDonald C, Sham P, Collier DA, Murray R, et al (2008). Neuregulin-1 and the P300 waveform--a preliminary association study using a psychosis endophenotype. Schizophr Res, 103(1-3), 178-185. Abstract.  Author URL.
Alkelai A, Baum A, Carless M, Crowley J, DasBanerjee T, Dempster E, Docherty S, Hare E, Galsworthy MJ, Grover D, et al (2008). The XVth World Congress of Psychiatric Genetics, October 7-11, 2007: Rapporteur summaries of oral presentations.  Abstract.

2007

Dempster EL, Burcescu I, Wigg K, Kiss E, Baji I, Gadoros J, Tamás Z, Kennedy JL, Vetró A, Kovacs M, et al (2007). Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. Arch Gen Psychiatry, 64(10), 1189-1195. Abstract.  Author URL.
Dempster EL, Kiss E, Kapornai K, Daroczy G, Mayer L, Baji I, Tamas Z, Gadoros J, Kennedy JL, Vetro A, et al (2007). No evidence of association between a functional polymorphism in the MTHFR gene and childhood-onset mood disorders. MOLECULAR PSYCHIATRY, 12(12), 1063-1064. Author URL.

2006

Dempster EL, Toulopoulou T, McDonald C, Bramon E, Walshe M, Wickham H, Sham PC, Murray RM, Collier DA (2006). Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.  Author URL.
Mill J, Dempster E, Caspi A, Williams B, Moffitt T, Craig I (2006). Evidence for monozygotic twin (MZ) discordance in methylation level at two CpG sites in the promoter region of the catechol-O-methyltransferase (COMT) gene. Am J Med Genet B Neuropsychiatr Genet, 141B(4), 421-425. Abstract.  Author URL.
Dempster E, Burcescu I, Wigg K, Kiss E, Baji I, Vetro A, Kennedy J, Marika K, Barr C (2006). Investigation of the genes encoding arginine vasopressin (AVP) and its receptor (AVPR1B) in childhood-onset mood disorder.  Author URL.
Dempster EL, Wigg KG, Vetro A, Kiss E, Kaponai K, Mayer L, Gadoros J, Kennedy J, Kovacs M, Barr CL, et al (2006). Investigation of the genes encoding substance P (TAC1) and its receptor (TACR1) in childhood-onset depression.  Author URL.
Bramon E, Dempster E, Frangou S, McDonald C, Schoenberg P, MacCabe JH, Walshe M, Sham P, Collier D, Murray RM, et al (2006). Is there an association between the COMT gene and P300 endophenotypes?. Eur Psychiatry, 21(1), 70-73. Abstract.  Author URL.
Reynolds GP, Piyabhan P, Nudmamud-Thanoi S, Dempster E, Collier DA (2006). Neuregulin polymorphism associates with indicators of Glutamatergic synaptic function in human post-mortem striatium.  Author URL.
Bramon E, Dempster E, Frangou S, Walshe M, McDonald C, Sham P, Collier D, Murray R (2006). Neuregulin-1 is associated with slower cognitive processing in schizophrenia.  Author URL.
Fernandes C, Hoyle E, Dempster E, Schalkwyk LC, Collier DA (2006). Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav, 5(6), 433-440. Abstract.  Author URL.
Dempster EL, Mill J, Craig IW, Collier DA (2006). The quantification of COMT mRNA in post mortem cerebellum tissue: diagnosis, genotype, methylation and expression. BMC Med Genet, 7 Abstract.  Author URL.

2005

Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F, Wickham H, Sham PC, Murray RM, Collier DA, et al (2005). Association between BDNF val66 met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet, 134B(1), 73-75. Abstract.  Author URL.
McDonald C, Bullmore ET, Dempster E, Chitnis XA, Sham PC, Collier DA, Murray RM (2005). Association between brain structural endophenotypes of psychotic disorders and genotypic variation.  Author URL.
Dempster EL, Mill J, Craig IW, Collier DA (2005). Does COMT promoter methylation regulate gene expression?.  Author URL.
Bramon E, Dempster E, Shaikh M, McDonald C, Walshe M, MacCabe J, Frangou S, Collier D, Murray R (2005). Genetic influences on brain physiology in schizophrenia.  Author URL.
Mill J, Caspi A, Dempster EL, Williams BS, Moffitt TE, Craig I (2005). Methylation analysis of a NGF1-A transcription factor binding-site in the promoter region of the human glucocorticoid receptor gene (NR3C1).  Author URL.

2004

McDonald C, Bullmore ET, Chitnis X, Dempster E, Sham P, Collier D, Murray R (2004). Brain structural endophenotypes of psychotic disorders and their association with genotypic variation.  Author URL.
Dempster EL, Mill JS, Murray R, Collier DA (2004). Expression analysis of five schizophrenia candidate genes in post-mortem cerebellum samples using quantitative real time RT-PCR.  Author URL.
Dempster EL, Toulopoulou T, Wickham H, Bramon E, McDonald C, Sham P, Murray R, Collier D (2004). The presence of a 2BP deletion in exon 6 of the 'alpha 7-like' nicotinic receptor subunit gene predicts worse performance in an episodic memory.  Author URL.

2003

Dempster EL, Li T, Ashworth A, Liu X, Collier DA (2003). Reelin as a candidate gene for schizophrenia.  Author URL.

2001

Dempster EL, Li T, Ashworth A, Liu X, St Clair D, Breen G, Collier D (2001). Reelin as a candidate gene for schizophrenia. AMERICAN JOURNAL OF MEDICAL GENETICS, 105(7), 624-625. Author URL.

1999

Dempster EL, Pryor KV, Francis D, Young JE, Rogers HJ (1999). Rapid DNA extraction from ferns for PCR-based analyses. BioTechniques, 27(1), 66-68.

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