Dr Eilis Hannon
Senior Research Fellow
E.J.Hannon@exeter.ac.uk
8162
+44 (0) 1392 728162
RILD Building
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK
Overview
Eilis Hannon is a Senior Research Fellow in the Complex Disease Epigenetics Group at the University of Exeter Medical School following her undergraduate in Mathematics and PhD in Bioinformatics. Her research focuses on integrating multiple layers of genomic data from a range of technologies to model the dynamic nature of gene expression and epigenetic variation and explore how this mediates genetic risk for complex diseases. She currently holds a Research Software Engineering Fellowhip from the EPSRC, where in addition to developing bespoke software for modeling genomic data, she advocates for reproducible research methods and facilitates wider development of computational skills for staff and students across the University. She has been awarded funding from the Brain and Behaviour Foundation, Alzheimer's Society and Alan Turing Institute. She is co-module lead for Health Statistics for Data Scientists MSc module, the Data Science Theme Lead for CBS, IDSAI Assistant Director for Education, Data Science Lead in the MRC funded GW4 Biomed DTP, and Joint Institutional Reproducibility Lead.
Qualifications
BSc Mathematics Cardiff University
PhD Bioinformatics Cardiff Univeristy
Career
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Senior Research Fellow (Nov 2017 - present); Research Fellow (Dec 2014 - Nov 2017); Research Associate Fellow (Nov 2013 - Dec 2014) |
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Bioinformatics post with primary focus on integrating epigenetic data with genomic and transcriptomic data and establishing analysis pipelines for the research group. Responsibilities include designing, implementing and supporting bioinformatic and statistical analyses of multidimensional datasets across a broad range of projects and phenotypes including identifying methylation QTLs, and epigenome-wide association studies; presenting and reporting findings. |
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Summer Student, Biomedical Systems Analysis Research Group, MRC, Human Genetics Unit, Edinburgh June 2009- Sept 2009 |
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10 week research project entitled ‘Visualization of Genome Wide Association Studies Data in Networks’. Used R and Biolayout software programs to investigate presenting correlations between traits in GWAS data as networks. Produced a written report and performed an oral presentation of conclusions. |
Links
Research group links
Research
Research interests
Her research focuses on integrating multiple layers of genomic data from a range of technologies to model the dynamic nature of gene expression and epigenetic variation and explore how this mediates genetic risk for complex diseases.
Research grants
- 2021 EPSRC
Research Software Engineer Fellowship: Development of software to model multi-modal genomic data as an integrated system: application to understanding the gene regulatory landscape - 2019 Alan Turing Institute
Characterising the gene regulatory landscape of neural cells. - 2017 Brain and Behavior Research Foundation
Young Investigator Award: Investigating the role of alternative splicing in the brain of schizophrenia patients. - 2016 Software Sustainability Institute
Software Sustainability Institute Fellowship - 2016 Alzheimers Society
PhD Studentship - 2015 Alzheimers Society
The contribution of epigenetic phenomena to Alzheimer's disease: an integrated genetic-epigenetic analysis.
Publications
Journal articles
Mill J, Leung SK, Ribarska T, Hannon E, Smith A, Pishva E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, et al (In Press). A histone acetylome-wide association study of Alzheimer’s disease identifies disease-associated H3K27ac differences in the entorhinal cortex. Nature Neuroscience
Hannon EJ, Knox O, Sugden K, Burrage J, Wong CCY, Belsky DW, Corcoran DL, Arsenault L, Moffitt TE, Caspi A, et al (In Press). Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. PLoS Genetics
Murphy T (In Press). DNA methylation and inflammation marker profiles associated with a self-reported history of depression. Human Molecular Genetics
Mill J, Hannon E (In Press). Variable DNA methylation in neonates mediates the association between prenatal smoking and birth weight. Philosophical Transactions B: Biological Sciences
Hannon E, Mill J, Dempster E, Walker E, Franklin A, Chioza B, Commins G, Davies J, Burrage J (2024). Quantifying the proportion of different cell types in the human cortex using DNA methylation profiles. BMC Biology
Bamford RA, Leung SK, Jeffries AR, Franklin A, Commin G, Davies J, Dempster E, Hannon E, Mill J (2023). 59. ULTRA-DEEP LONG READ TRANSCRIPTOME SEQUENCING REVEALS DRAMATIC ISOFORM DIVERSITY ACROSS HUMAN CORTEX DEVELOPMENT: RELEVANCE FOR GENETIC STUDIES OF PSYCHIATRIC DISORDERS. European Neuropsychopharmacology, 75
Doherty T, Dempster E, Hannon E, Mill J, Poulton R, Corcoran D, Sugden K, Williams B, Caspi A, Moffitt TE, et al (2023). A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator. BMC Bioinformatics, 24(1).
Caspi A, Shireby G, Mill J, Moffitt TE, Sugden K, Hannon E (2023). Accelerated Pace of Aging in Schizophrenia: Five Case-Control Studies. Biological Psychiatry
Nabais MF, Gadd DA, Hannon E, Mill J, McRae AF, Wray NR (2023). An overview of DNA methylation-derived trait score methods and applications. Genome Biol, 24(1). Abstract. Author URL.
Sugden K, Moffitt TE, Arpawong TE, Arseneault L, Belsky DW, Corcoran DL, Crimmins EM, Hannon E, Houts R, Mill JS, et al (2023). Cross-National and Cross-Generational Evidence That Educational Attainment May Slow the Pace of Aging in European-Descent Individuals. The Journals of Gerontology Series B, 78(8), 1375-1385.
Lin S, Hannon E, Waring JF, Reppell M, Smaoui N, Pivorunas VL, Guay H, Chanchlani N, Bewshea C, Bai BYH, et al (2023). DOP88 Understanding the molecular mechanisms of anti-TNF treatment failure: Whole blood DNA methylation changes associated with primary non-response to anti-TNF treatment in patients with Crohn’s disease. Journal of Crohn's and Colitis, 17(Supplement_1), i164-i166.
Alameda L, Liu Z, Sham PC, Aas M, Trotta G, Rodriguez V, Di Forti M, Stilo SA, Kandaswamy R, Arango C, et al (2023). Exploring the mediation of DNA methylation across the epigenome between childhood adversity and First Episode of Psychosis-findings from the EU-GEI study. Mol Psychiatry, 28(5), 2095-2106. Abstract. Author URL.
Villicaña S, Castillo-Fernandez J, Hannon E, Christiansen C, Tsai P-C, Maddock J, Kuh D, Suderman M, Power C, Relton C, et al (2023). Genetic impacts on DNA methylation help elucidate regulatory genomic processes. Genome Biology, 24(1).
Leung SK, Castanho I, Jeffries A, Moore K, Dempster E, Brown JT, Bamford R, Hannon E, Mill J (2023). Isoform characterisation & splicing signatures of AD‐risk genes using long‐read sequencing. Alzheimer's & Dementia, 19(S12).
Spindola L, Stavrum A-K, O'Connell K, Hannon E, Mill J, Djurovic S, Melle I, Andreassen O, Le Hellard S (2023). T86. PREDICTING PSYCHOSIS: EXPLORING THE ADDITIVE AND INTERACTION EFFECTS OF GENETIC AND EPIGENETIC RISK SCORES. European Neuropsychopharmacology, 75
Mill J, Hannon E, Dempster E, Franklin A, Burrage J, Davies J, Chioza B, Commin G, Jeffries AR, Bamford RA, et al (2023). W76. CELL-SPECIFIC METHYLOMIC VARIATION IN NEURODEVELOPMENT AND SCHIZOPHRENIA. European Neuropsychopharmacology, 75, s144-s145.
Lin S, Hannon E, Reppell M, Waring JF, Smaoui N, Pivorunas V, Guay H, Chanchlani N, Bewshea C, Bai BYH, et al (2023). Whole blood DNA methylation changes are associated with anti-TNF drug concentration in patients with Crohn's disease. J Crohns Colitis Abstract. Author URL.
Davies J, Franklin A, Walker E, Owens N, Bray N, Bamford RA, Commin G, Chioza B, Burrage J, Dempster E, et al (2022). 1. DEVELOPMENTAL TRAJECTORIES OF DNA METHYLATION IN NEURAL CELL POPULATIONS IN HUMAN CORTEX AND LINKS TO NEURODEVELOPMENTAL DISORDERS. European Neuropsychopharmacology, 63
Hannon E, Jeffries AR, Policicchio S, Viana J, Leung SK, Dempster E, Mill J (2022). 42. LEVERAGING a BESPOKE CORTICAL TRANSCRIPTOME TO ASSESS THE ROLE OF ALTERNATIVE SPLICING IN SCHIZOPHRENIA. European Neuropsychopharmacology, 63, e67-e68.
Bamford R, Jeffries AR, Walker E, Leung SK, Commin G, Davies JP, Dempster E, Hannon E, Mill J (2022). 67. LONG READ TRANSCRIPTOME SEQUENCING REVEALS ISOFORM DIVERSITY ACROSS HUMAN NEURODEVELOPMENT. European Neuropsychopharmacology, 63, e81-e82.
Hannon E, Davies J, Chioza B, Policicchio S, Burrage J, Commin G, Jeffries AR, Schalkwyk L, Dempster E, Mill J, et al (2022). 89. IDENTIFYING CELL-TYPE-SPECIFIC EPIGENETIC VARIATION IN THE CORTEX ASSOCIATED WITH SCHIZOPHRENIA. European Neuropsychopharmacology, 63, e93-e94.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2022). Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet, 54(3). Author URL.
Shireby G, Dempster EL, Policicchio S, Smith RG, Pishva E, Chioza B, Davies JP, Burrage J, Lunnon K, Seiler Vellame D, et al (2022). DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types. Nature Communications, 13(1). Abstract.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, et al (2022). DunedinPACE, a DNA methylation biomarker of the pace of aging. Elife, 11 Abstract. Author URL.
Pihlstrøm L, Shireby G, Geut H, Henriksen SP, Rozemuller AJM, Tunold J-A, Hannon E, Francis P, Thomas AJ, Love S, et al (2022). Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology. Nature Communications, 13(1). Abstract.
Flynn R, Washer S, Jeffries AR, Andrayas A, Shireby G, Kumari M, Schalkwyk LC, Mill J, Hannon E (2022). Evaluation of nanopore sequencing for epigenetic epidemiology: a comparison with DNA methylation microarrays. Hum Mol Genet, 31(18), 3181-3190. Abstract. Author URL.
Washer SJ, Flynn R, Oguro‐Ando A, Hannon E, Burrage J, Jeffries A, Mill J, Dempster EL (2022). Functional characterization of the schizophrenia associated gene <scp><i>AS3MT</i></scp> identifies a role in neuronal development. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 189(5), 151-162. Abstract.
Devall M, Soanes DM, Smith AR, Dempster EL, Smith RG, Burrage J, Iatrou A, Hannon E, Troakes C, Moore K, et al (2022). Genome-wide characterization of mitochondrial DNA methylation in human brain. Front Endocrinol (Lausanne), 13 Abstract. Author URL.
Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J, et al (2022). Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS. Science Translational Medicine, 14(633). Abstract.
Ruf WP, Hannon E, Freischmidt A, Grozdanov V, Brenner D, Müller K, Knehr A, Günther K, Dorst J, Ammerpohl O, et al (2022). Methylome analysis of ALS patients and presymptomatic mutation carriers in blood cells. Neurobiol Aging, 116, 16-24. Abstract. Author URL.
Bao Y, Gorrie-Stone T, Hannon E, Hughes A, Andrayas A, Neilson G, Burrage J, Mill J, Schalkwyk L, Kumari M, et al (2022). Social mobility across the lifecourse and DNA methylation age acceleration in adults in the UK. Sci Rep, 12(1). Abstract. Author URL.
Vellame DS, Shireby G, MacCalman A, Dempster EL, Burrage J, Gorrie-Stone T, Schalkwyk LS, Mill J, Hannon E (2022). Uncertainty quantification of reference-based cellular deconvolution algorithms. Epigenetics, 18(1).
Gunasekara CJ, Hannon E, MacKay H, Coarfa C, McQuillin A, Clair DS, Mill J, Waterland RA (2021). A machine learning case–control classifier for schizophrenia based on DNA methylation in blood. Translational Psychiatry, 11(1). Abstract.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (2021). A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex. Nat Commun, 12(1). Abstract. Author URL.
Hannon E, Mansell G, Walker E, Nabais MF, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt TE, et al (2021). Assessing the co-variability of DNA methylation across peripheral cells and tissues: Implications for the interpretation of findings in epigenetic epidemiology. PLoS Genet, 17(3). Abstract. Author URL.
Vellame DS, Castanho I, Dahir A, Mill J, Hannon E (2021). Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation. Abstract.
Seiler Vellame D, Castanho I, Dahir A, Mill J, Hannon E (2021). Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation. BMC Genomics, 22(1). Abstract. Author URL.
van Rheenen W, van der Spek RAA, Bakker MK, van Vugt JJFA, Hop PJ, Zwamborn RAJ, de Klein N, Westra H-J, Bakker OB, Deelen P, et al (2021). Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat Genet, 53(12), 1636-1648. Abstract. Author URL.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forti M, et al (2021). DNA methylation meta-analysis reveals cellular alterations in psychosis and markers of treatment-resistant schizophrenia. eLife, 10 Abstract.
Kandaswamy R, Hannon E, Arseneault L, Mansell G, Sugden K, Williams B, Burrage J, Staley JR, Pishva E, Dahir A, et al (2021). DNA methylation signatures of adolescent victimization: analysis of a longitudinal monozygotic twin sample. Epigenetics, 16(11), 1169-1186. Abstract. Author URL.
van Dongen J, Hagenbeek FA, Suderman M, Roetman PJ, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty JD, Adams MJ, et al (2021). DNA methylation signatures of aggression and closely related constructs: a meta-analysis of epigenome-wide studies across the lifespan. Mol Psychiatry, 26(6), 2148-2162. Abstract. Author URL.
Wang Y, Hannon E, Grant OA, Gorrie-Stone TJ, Kumari M, Mill J, Zhai X, McDonald-Maier KD, Schalkwyk LC (2021). DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. BMC Genomics, 22(1). Abstract. Author URL.
Belsky DW, Caspi A, Corcoran DL, Sugden K, Poulton R, Arseneault L, Baccarelli A, Chamarti K, Gao X, Hannon E, et al (2021). DunedinPACE: a DNA methylation biomarker of the Pace of Aging. Abstract.
Pihlstrøm L, Shireby G, Geut H, Henriksen SP, Rozemüller AJM, Tunold J-A, Hannon E, Francis P, Thomas AJ, Love S, et al (2021). Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology. Abstract.
Leung SK, Jeffries AR, Castanho I, Jordan BT, Moore K, Davies JP, Dempster EL, Bray NJ, O’Neill P, Tseng E, et al (2021). Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing. Cell Reports, 37(7), 110022-110022.
Hop PJ, Zwamborn RAJ, Hannon E, Shireby GL, Nabais MF, Walker EM, van Rheenen W, van Vugt JJFA, Dekker AM, Westeneng H-J, et al (2021). Genome-wide study of DNA methylation in Amyotrophic Lateral Sclerosis identifies differentially methylated loci and implicates metabolic, inflammatory and cholesterol pathways. Abstract.
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nat Genet, 53(9), 1311-1321. Abstract. Author URL.
van Dongen J, Gordon SD, McRae AF, Odintsova VV, Mbarek H, Breeze CE, Sugden K, Lundgren S, Castillo-Fernandez JE, Hannon E, et al (2021). Identical twins carry a persistent epigenetic signature of early genome programming. Nature Communications, 12(1). Abstract.
Zhang N, Ranson JM, Zheng Z-J, Hannon E, Zhou Z, Kong X, Llewellyn DJ, King DA, Huang J (2021). Interaction between genetic predisposition, smoking, and dementia risk: a population-based cohort study. Sci Rep, 11(1). Abstract. Author URL.
Nabais MF, Laws SM, Lin T, Vallerga CL, Armstrong NJ, Blair IP, Kwok JB, Mather KA, Mellick GD, Sachdev PS, et al (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biol, 22(1). Abstract. Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2021). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Mol Brain, 14(1). Abstract. Author URL.
Kouakou MR, Cameron D, Hannon E, Dempster EL, Mill J, Hill MJ, Bray NJ (2021). Sites of active gene regulation in the prenatal frontal cortex and their role in neuropsychiatric disorders. Am J Med Genet B Neuropsychiatr Genet, 186(6), 376-388. Abstract. Author URL.
Smith RG, Pishva E, Shireby G, Smith AR, Roubroeks JAY, Hannon E, Wheildon G, Mastroeni D, Gasparoni G, Riemenschneider M, et al (2020). A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex. Abstract.
Roubroeks JAY, Smith AR, Smith RG, Pishva E, Ibrahim Z, Sattlecker M, Hannon EJ, Kłoszewska I, Mecocci P, Soininen H, et al (2020). An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene. Neurobiol Aging, 95, 26-45. Abstract. Author URL.
Hannon E, Shireby G, Brookes KJ, Neilson G, Dahir A, Walker E, Lunnon K, Love S, Thomas AJ, Morgan K, et al (2020). An integrated epigenetic‐genetic study of neuropathology in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).
Hannon E, Mansell G, Burrage J, Kepa A, Best-Lane J, Rose A, Heck S, Moffitt T, Caspi A, Arseneault L, et al (2020). Assessing the co-variability of DNA methylation across peripheral cells and tissues: implications for the interpretation of findings in epigenetic epidemiology. Abstract.
Hannon E, Brookes KJ, Shireby G, Attems J, Sims R, Cairns NJ, Morgan K, Thomas AJ, Francis PT, Mill J, et al (2020). Assessment of the contribution of common genetic variants associated with Alzheimer’s disease on neuropathological burden and clinical characteristics in the Brains for Dementia Research cohort. Alzheimer's & Dementia, 16(S2).
Leung SK, Jeffries A, Hannon E, Castanho I, Moore K, Murray TK, Ahmed Z, Collier DA, Mill J (2020). Characterization of mRNA isoform diversity in a transgenic model of tau pathology using targeted long‐read sequencing. Alzheimer's & Dementia, 16(S3).
Viana J, Wildman N, Hannon E, Farbos A, Neill PO, Moore K, van Aerle R, Paull G, Santos E, Mill J, et al (2020). Clozapine-induced transcriptional changes in the zebrafish brain. NPJ Schizophr, 6(1). Abstract. Author URL.
Hop PJ, Zwamborn RAJ, Hannon EJ, Dekker AM, van Eijk KR, Walker EM, Iacoangeli A, Jones AR, Shatunov A, Khleifat AA, et al (2020). Cross-reactive probes on Illumina DNA methylation arrays: a large study on ALS shows that a cautionary approach is warranted in interpreting epigenome-wide association studies. NAR Genomics and Bioinformatics, 2(4). Abstract.
van Dongen J, Hagenbeek FA, Suderman M, Roetman P, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty J, Adams MJ, et al (2020). DNA methylation signatures of aggression and closely related constructs: a meta-analysis of epigenome-wide studies across the lifespan. Abstract.
Wang Y, Hannon E, Grant OA, Gorrie-Stone TJ, Kumari M, Mill J, Zhai X, McDonald-Maier KD, Schalkwyk LC (2020). DNA methylation-based sex classifier to predict sex and identify sex chromosome aneuploidy. Abstract.
Rovira P, Sánchez-Mora C, Pagerols M, Richarte V, Corrales M, Fadeuilhe C, Vilar-Ribó L, Arribas L, Shireby G, Hannon E, et al (2020). Epigenome-wide association study of attention-deficit/hyperactivity disorder in adults. Translational Psychiatry, 10(1). Abstract.
Jeffries AR, Leung SK, Castanho I, Moore K, Davies JP, Dempster EL, Bray NJ, O‘Neill P, Tseng E, Ahmed Z, et al (2020). Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex. Abstract.
Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (2020). Genetic risk for Alzheimer’s disease influences neuropathology and cognition via multiple biological pathways. Abstract.
Hannon E, Shireby GL, Brookes K, Attems J, Sims R, Cairns NJ, Love S, Thomas AJ, Morgan K, Francis PT, et al (2020). Genetic risk for Alzheimer’s disease influences neuropathology via multiple biological pathways. Brain Communications, 2(2). Abstract.
Meijer M, Klein M, Hannon E, van der Meer D, Hartman C, Oosterlaan J, Heslenfeld D, Hoekstra PJ, Buitelaar J, Mill J, et al (2020). Genome-Wide DNA Methylation Patterns in Persistent Attention-Deficit/Hyperactivity Disorder and in Association with Impulsive and Callous Traits. Front Genet, 11 Abstract. Author URL.
Policicchio S, Washer S, Viana J, Iatrou A, Burrage J, Hannon E, Turecki G, Kaminsky Z, Mill J, Dempster EL, et al (2020). Genome-wide DNA methylation meta-analysis in the brains of suicide completers. Translational Psychiatry, 10(1). Abstract.
Castanho I, Murray TK, Leung SK, Hannon E, Jeffries A, Lunnon K, Ahmed Z, Mill J (2020). Genome‐wide DNA methylation signatures of tau and amyloid neuropathology. Alzheimer's & Dementia, 16(S3).
Min JL, Hemani G, Hannon E, Dekkers KF, Castillo-Fernandez J, Luijk R, Carnero-Montoro E, Lawson DJ, Burrows K, Suderman M, et al (2020). Genomic and phenomic insights from an atlas of genetic effects on DNA methylation. Abstract.
Chan RF, Shabalin AA, Montano C, Hannon E, Hultman CM, Fallin MD, Feinberg AP, Mill J, van den Oord EJCG, Aberg KA, et al (2020). Independent Methylome-Wide Association Studies of Schizophrenia Detect Consistent Case-Control Differences. Schizophr Bull, 46(2), 319-327. Abstract. Author URL.
Hannon E, Dempster EL, Mansell G, Burrage J, Bass N, Bohlken MM, Corvin A, Curtis CJ, Dempster D, Di Forta M, et al (2020). Large-scale analysis of DNA methylation identifies cellular alterations in blood from psychosis patients and molecular biomarkers of treatment-resistant schizophrenia. Abstract.
Sadahiro R, Knight B, James F, Hannon E, Charity J, Daniels IR, Burrage J, Knox O, Crawford B, Smart NJ, et al (2020). Major surgery induces acute changes in measured DNA methylation associated with immune response pathways. Sci Rep, 10(1). Abstract. Author URL.
Steg LC, Shireby GL, Imm J, Davies JP, Franklin A, Flynn R, Namboori SC, Bhinge A, Jeffries AR, Burrage J, et al (2020). Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons. Abstract.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, et al (2020). Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement. Patterns, 1(2), 100014-100014.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Corcoran DL, Fisher HL, Houts RM, Kandaswamy R, Moffitt TE, Poulton R, et al (2020). Patterns of Reliability: Assessing the Reproducibility and Integrity of DNA Methylation Measurement. Patterns (N Y), 1(2). Abstract. Author URL.
Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran DL, Gao X, Hannon E, Harrington HL, Rasmussen LJH, Houts R, et al (2020). Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. eLife, 9 Abstract.
Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran D, Gao X, Hannon E, Harrington HL, Rasmussen LJH, Houts R, et al (2020). Quantification of the pace of biological aging in humans through a blood test: the DunedinPoAm DNA methylation algorithm. Abstract.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (2020). Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex. Abstract.
Shireby GL, Davies JP, Francis PT, Burrage J, Walker EM, Neilson GWA, Dahir A, Thomas AJ, Love S, Smith RG, et al (2020). Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex. Brain, 143(12), 3763-3775. Abstract. Author URL.
Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang F, Vallerga CL, Restuadi R, Freydenzon A, et al (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine, 5(1). Abstract.
Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang F, Vallerga CL, Restuadi R, Freydenzon A, et al (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. NPJ Genom Med, 5(1). Abstract. Author URL.
Castanho I, Murray TK, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Bradshaw L, Randall A, et al (2020). Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell Rep, 30(6), 2040-2054.e5. Abstract. Author URL.
Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ (2019). Association of Lifestyle and Genetic Risk with Incidence of Dementia. JAMA - Journal of the American Medical Association Abstract.
Clifton NE, Hannon E, Harwood JC, Di Florio A, Thomas KL, Holmans PA, Walters JTR, O’Donovan MC, Owen MJ, Pocklington AJ, et al (2019). Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry, 9(1). Abstract.
Ori APS, Olde Loohuis LM, Guintivano J, Hannon E, Dempster E, St. Clair D, Bass NJ, McQuillin A, Mill J, Sullivan PF, et al (2019). Epigenetic age is accelerated in schizophrenia with age- and sex-specific effects and associated with polygenic disease risk. Abstract.
van Dongen J, Zilhão NR, Sugden K, BIOS Consortium, Hannon EJ, Mill J, Caspi A, Agnew-Blais J, Arseneault L, Corcoran DL, et al (2019). Epigenome-wide Association Study of Attention-Deficit/Hyperactivity Disorder Symptoms in Adults. Biol Psychiatry, 86(8), 599-607. Abstract. Author URL.
Sugden K, Hannon EJ, Arseneault L, Belsky DW, Broadbent JM, Corcoran DL, Hancox RJ, Houts RM, Moffitt TE, Poulton R, et al (2019). Establishing a generalized polyepigenetic biomarker for tobacco smoking. Transl Psychiatry, 9(1). Abstract. Author URL.
Hannon E, Marzi SJ, Schalkwyk LS, Mill J (2019). Genetic risk variants for brain disorders are enriched in cortical H3K27ac domains. Mol Brain, 12(1). Abstract. Author URL.
Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, et al (2019). Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue. Hum Mol Genet, 28(13), 2201-2211. Abstract. Author URL.
Mansell G, Gorrie-Stone TJ, Bao Y, Kumari M, Schalkwyk LS, Mill J, Hannon E (2019). Guidance for DNA methylation studies: statistical insights from the Illumina EPIC array. BMC Genomics, 20(1). Abstract. Author URL.
Massrali A, Brunel H, Hannon E, Wong C, Baron-Cohen S, Warrier V (2019). Integrated genetic and methylomic analyses identify shared biology between autism and autistic traits. Molecular Autism, 10(1).
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Mill J, Relton C, Arseneault L, Wong CCY, Fisher HL, et al (2019). Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences. Transl Psychiatry, 9(1). Abstract. Author URL.
Kowalec K, Hannon E, Mansell G, Burrage J, Ori APS, Ophoff RA, Mill J, Sullivan PF (2019). Methylation age acceleration does not predict mortality in schizophrenia. Transl Psychiatry, 9(1). Abstract. Author URL.
Kuzma E, Lourida I, Hannon E, Littlejohns TJ, Langa KM, Hyppönen E, Llewellyn DJ (2019). O3‐05‐02: GENETIC RISK, LIFESTYLE AND DEMENTIA. Alzheimer's & Dementia, 15(7S_Part_17), p890-p890.
Smith RG, Pishva E, Shireby G, Smith AR, Hannon E, Sharp AJ, Mastroeni DF, Schalkwyk LC, Haroutunian V, Coleman PD, et al (2019). O4‐10‐06: INTEGRATED GENETIC‐EPIGENETIC ANALYSES OF ALZHEIMER'S DISEASE. Alzheimer's & Dementia, 15(7S_Part_24), p1261-p1261.
Kuzma E, Lourida I, Hannon E, Littlejohns TJ, Llewellyn DJ (2019). P2‐549: BODY MASS INDEX, GENETIC RISK AND ALL‐CAUSE DEMENTIA. Alzheimer's & Dementia, 15(7S_Part_16), p830-p831.
Smith AR, Smith RG, Pishva E, Hannon E, Roubroeks JAY, Burrage J, Troakes C, Al-Sarraj S, Sloan C, Mill J, et al (2019). Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease. Clin Epigenetics, 11(1). Abstract. Author URL.
El Khoury LY, Gorrie-Stone T, Smart M, Hughes A, Bao Y, Andrayas A, Burrage J, Hannon E, Kumari M, Mill J, et al (2019). Systematic underestimation of the epigenetic clock and age acceleration in older subjects. Genome Biol, 20(1). Abstract. Author URL.
Hughes A, Bao Y, Smart M, Gorrie-Stone T, Hannon E, Mill J, Burrage J, Schalkwyk L, Kumari M (2019). THE AUTHORS REPLY. American Journal of Epidemiology, 188(2), 488-489.
Castanho I, Murray T, Hannon E, Jeffries A, Walker E, Laing E, Baulf H, Harvey J, Randall A, Moore K, et al (2019). Transcriptional Signatures of Progressive Neuropathology in Transgenic Models of Tau and Amyloid Pathology.
Marzi SJ, Sugden K, Arsenault L, Belsky DW, Burrage J, Corcoran DL, Danese A, Fisher HL, Hannon EJ, Moffitt TE, et al (2018). Analysis of DNA Methylation in Young People: Limited Evidence for an Association Between Victimization Stress and Epigenetic Variation in Blood. American Journal of Psychiatry
Luijk R, Wu H, Ward-Caviness CK, Hannon E, Carnero-Montoro E, Min JL, Mandaviya P, Müller-Nurasyid M, Mei H, van der Maarel SM, et al (2018). Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation. Nature Communications, 9(1). Abstract. Author URL.
Gorrie-Stone TJ, Smart MC, Saffari A, Malki K, Hannon E, Burrage J, Mill J, Kumari M, Schalkwyk LC (2018). Bigmelon: tools for analysing large DNA methylation datasets. Bioinformatics, bty713-bty713. Abstract. Author URL.
Smith RG, Hannon E, De Jager PL, Chibnik L, Lott SJ, Condliffe D, Smith AR, Haroutunian V, Troakes C, Al-Sarraj S, et al (2018). Elevated DNA methylation across a 48-kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology. Alzheimers Dement, 14(12), 1580-1588. Abstract. Author URL.
Hannon E, Schendel D, Ladd-Acosta C, Grove J, Hansen CS, Andrews SV, Hougaard DM, Bresnahan M, Mors O, Hollegaard MV, et al (2018). Elevated polygenic burden for autism is associated with differential DNA methylation at birth. Genome Medicine, 10(1). Abstract. Author URL.
O'Brien HE, Hannon E, Hill MJ, Toste CC, Robertson MJ, Morgan JE, McLaughlin G, Lewis CM, Schalkwyk LC, Hall LS, et al (2018). Expression quantitative trait loci in the developing human brain and their enrichment in neuropsychiatric disorders. Genome Biol, 19(1). Abstract. Author URL.
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, et al (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet, 50(5), 668-681. Abstract. Author URL.
Clissold RL, Ashfield B, Burrage J, Hannon E, Bingham C, Mill J, Hattersley A, Dempster EL (2018). Genome-wide methylomic analysis in individuals with HNF1B intragenic mutation and 17q12 microdeletion. Clin Epigenetics, 10(1). Abstract. Author URL.
Hannon E, Gorrie-Stone TJ, Smart MC, Burrage J, Hughes A, Bao Y, Kumari M, Schalkwyk LC, Mill J (2018). Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traits. Abstract.
Hannon E, Gorrie-Stone TJ, Smart MC, Burrage J, Hughes A, Bao Y, Kumari M, Schalkwyk LC, Mill J (2018). Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits. American Journal of Human Genetics, 103(5), 654-665. Abstract.
Marioni RE, McRae AF, Bressler J, Colicino E, Hannon E, Li S, Prada D, Smith JA, Trevisi L, Tsai P-C, et al (2018). Meta-analysis of epigenome-wide association studies of cognitive abilities. Mol Psychiatry, 23(11), 2133-2144. Abstract. Author URL.
O’Brien HE, Hannon E, Jeffries AR, Davies W, Hill MJ, Anney RJ, O’Donovan MC, Mill J, Bray NJ (2018). Sex differences in gene expression in the human fetal brain. Abstract.
Hughes A, Smart M, Gorrie-Stone T, Hannon E, Mill J, Bao Y, Burrage J, Schalkwyk L, Kumari M (2018). Socioeconomic Position and DNA Methylation Age Acceleration Across the Life Course. Am J Epidemiol, 187(11), 2346-2354. Abstract. Author URL.
Kuźma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine DA, Lunnon K, Thompson-Coon J, Hyppönen E, Llewellyn DJ, et al (2018). Which Risk Factors Causally Influence Dementia? a Systematic Review of Mendelian Randomization Studies. J Alzheimers Dis, 64(1), 181-193. Abstract. Author URL.
Spiers H, Hannon EJ, Schalkwyk LS, Bray NJ, Mill J (2017). 5-hydroxymethylcytosine is highly dynamic across human fetal brain development. BMC Genomics, 18, 738-738.
Marzi SJ, Ribarska T, Smith AR, Hannon E, Poschmann J, Moore K, Troakes C, Al-Sarraj S, Beck S, Newman S, et al (2017). A histone acetylome-wide association study of Alzheimer’s disease: neuropathology-associated regulatory variation in the human entorhinal cortex. Abstract.
Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S (2017). Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nat Commun, 8 Abstract. Author URL.
Traylor M, Malik R, Nalls MA, Cotlarciuc I, Radmanesh F, Thorleifsson G, Hanscombe KB, Langefeld C, Saleheen D, Rost NS, et al (2017). Genetic variation at 16q24.2 is associated with small vessel stroke. Ann Neurol, 81(3), 383-394. Abstract. Author URL.
Pishva E, Kenis G, Hannon E, Viechtbauer W, Jeffries A, Lardenoije R, Sienaert P, van Os J, Stek ML, Rutten BPF, et al (2017). Genome-wide meta-analysis of DNA methylation changes associated with antidepressant effects of Electroconvulsive Therapy. Brain Stimulation, 10(2).
Murphy TM, Crawford B, Dempster EL, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J (2017). Methylomic profiling of cortex samples from completed suicide cases implicates a role for PSORS1C3 in major depression and suicide. Transl Psychiatry, 7(1). Abstract. Author URL.
Hannon E, Weedon M, Bray N, O'Donovan M, Mill J (2017). Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci. Am J Hum Genet, 100(6), 954-959. Abstract. Author URL.
Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K (2017). Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue. Clin Epigenetics, 9 Abstract. Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). SU116. Longitudinal Epigenetic Analysis of Clozapine Use in Treatment-Resistant Schizophrenia. Schizophrenia Bulletin, 43(suppl_1), s203-s203.
Viana J, Hannon E, Dempster E, Pidsley R, Macdonald R, Knox O, Spiers H, Troakes C, Al-Saraj S, Turecki G, et al (2017). Schizophrenia-associated methylomic variation: molecular signatures of disease and polygenic risk burden across multiple brain regions. Hum Mol Genet, 26(1), 210-225. Abstract. Author URL.
Spiers H, Hannon E, Wells S, Williams B, Fernandes C, Mill J (2016). Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model. Mech Ageing Dev, 154, 20-23. Abstract. Author URL.
Hannon E, Dempster E, Viana J, Burrage J, Smith AR, Macdonald R, St Clair D, Mustard C, Breen G, Therman S, et al (2016). An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol, 17(1). Abstract. Author URL.
Richardson TG, Shihab HA, Hemani G, Zheng J, Hannon E, Mill J, Carnero-Montoro E, Bell JT, Lyttleton O, McArdle WL, et al (2016). Collapsed methylation quantitative trait loci analysis for low frequency and rare variants. Hum Mol Genet, 25(19), 4339-4349. Abstract. Author URL.
Lunnon K, Hannon E, G.Smith R, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum [Genome Biol. 2016, 17, 27]. Genome Biology, 17(1).
Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S, et al (2016). Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nat Commun, 7 Abstract. Author URL.
Smith AR, Smith RG, Condliffe D, Hannon E, Schalkwyk L, Mill J, Lunnon K (2016). Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer's disease brain. Neurobiol Aging, 47, 35-40. Abstract. Author URL.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy TM, Troakes C, Turecki G, O'Donovan MC, Schalkwyk LC, et al (2016). Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat Neurosci, 19(1), 48-54. Abstract. Author URL.
Smith A, Smith R, Roubroeks J, Hannon E, Burrage J, Troakes C, van den Hove D, Mill J, Lunnon K (2016). O2‐06‐05: Hydroxymethylomic Profiling Implicates Cortical Deregulation of ANK1 and APP in the Alzheimer's Disease Brain. Alzheimer's & Dementia, 12(7S_Part_5), p240-p241.
Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, et al (2016). Variation in 5-hydroxymethylcytosine across human cortex and cerebellum. Genome Biol, 17 Abstract. Author URL.
Hannon E, Chand AN, Evans MD, Wong CCY, Grubb MS, Mill J (2015). A role for CaV1 and calcineurin signaling in depolarization-induced changes in neuronal DNA methylation. Neuroepigenetics, 3, 1-6.
Spiers H, Bray NJ, Hannon E, Schalkwyk LC, Wong CC, Pidsley R, Smith RG, Mill J (2015). Dynamic and sex-specific changes in DNA methylation during human fetal brain development. Int J Dev Neurosci, 47(Pt A), 50-51. Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2015). Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes. Epigenetics, 10(11), 1024-1032. Abstract. Author URL.
Fisher HL, Murphy TM, Arseneault L, Caspi A, Moffitt TE, Viana J, Hannon E, Pidsley R, Burrage J, Dempster EL, et al (2015). Methylomic analysis of monozygotic twins discordant for childhood psychotic symptoms. Epigenetics, 10(11), 1014-1023. Abstract. Author URL.
Murphy TM, Wong CCY, Arseneault L, Burrage J, Macdonald R, Hannon E, Fisher HL, Ambler A, Moffitt TE, Caspi A, et al (2015). Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins. Clin Epigenetics, 7 Abstract. Author URL.
Spiers H, Hannon E, Schalkwyk LC, Smith R, Wong CCY, O'Donovan MC, Bray NJ, Mill J (2015). Methylomic trajectories across human fetal brain development. Genome Res, 25(3), 338-352. Abstract. Author URL.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract.
Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, et al (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506(7487), 179-184. Abstract. Author URL.
Lunnon K, Smith R, Hannon E, De Jager PL, Srivastava G, Volta M, Troakes C, Al-Sarraj S, Burrage J, Macdonald R, et al (2014). Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease. Nat Neurosci, 17(9), 1164-1170. Abstract. Author URL.
Pidsley R, Viana J, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. GENOME BIOLOGY, 15(10). Author URL.
Pidsley R, Viana J, Hannon E, Spiers HH, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk LC, Bray NJ, et al (2014). Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia. Genome Biology, 15(10), 483-483.
Anderson‐Schmidt H, Beltcheva O, Brandon MD, Byrne EM, Diehl EJ, Duncan L, Gonzalez SD, Hannon E, Kantojärvi K, Karagiannidis I, et al (2013). Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14–18, 2012. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(2), 96-121. Abstract.
Conferences
Davies J, Franklin A, Commin G, Walker E, Policicchio S, Jeffries A, Burrage J, Chioza B, Liu J, Bray N, et al (2021). CELL-TYPE-SPECIFIC PATTERNS OF DNA METHYLATION IN THE DEVELOPING HUMAN BRAIN. Author URL.
Shireby G, Hannon E, Commin G, Burrage J, Davies J, Policicchio S, Schalkwyk L, Dempster E, Mill J (2021). LEVERAGING DNA METHYLATION QUANTITATIVE-TRAIT LOCI TO CHARACTERIZE THE RELATIONSHIP BETWEEN METHYLOMIC VARIATION, GENE EXPRESSION, AND PSYCHIATRIC DISEASE. Author URL.
van Dongen J, Hagenbeek FA, Suderman M, Roetman P, Sugden K, Chiocchetti AG, Ismail K, Mulder RH, Hafferty J, Adams MJ, et al (2020). DNA methylation signatures of a broad spectrum of aggressive behavior: a meta-analysis of epigenome-wide studies across the lifespan. Author URL.
Ranson JM, Lourida I, Hannon E, Littlejohns TJ, Ballard C, Langa KM, Hyppönen E, Kuzma E, Llewellyn DJ (2020). Genetic risk, education and incidence of dementia.
Ranson J, Lourida I, Hannon E, littlejohns T, Ballard C, langa K, hypponen E, Kuzma E, Llewellyn D (2020). Genetic risk, education and incidence of dementia. Alzheimer’s Association International Conference. 27th - 31st Jul 2020.
Meijer M, Klein M, Hannon E, Van der Meer D, Hartman C, Oosterlaan J, Heslenfeld D, Hoekstra P, Buitelaar J, Mill J, et al (2020). Genome-wide methylation patterns in persistent ADHD and in association with impulsive and callous traits. Author URL.
Gillespie A, Hannon E, Egerton A, Mill J, MacCabe J (2020). Longitudinal DNA methylation changes associated with improvement of psychotic symptoms during clozapine treatment. Author URL.
MacCalman A, De Franco E, Jeffries AR, Hannon EJ, Davies J, Burrage J, Morgan NG, Hattersley AT, Mill J (2020). Regulatory genomic variation in the developing human pancreas. Author URL.
Ranson J, Lourida ILIANNA, Hannon E, littlejohns T, Ballard C, langa K, hypponen E, Kuzma E, Llewellyn D (2020). Stroke, genetic risk and incidence of dementia. Alzheimer's Association International Conference. 27th - 31st Jul 2020.
Viana J, Wildman N, Hannon E, Farbos A, O'Neill P, Moore K, Paszkiewicz K, van Aerle R, Paull G, Santos E, et al (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN. Author URL.
Viana J, Hannon E, van Aerle R, Dempster E, Paull G, Santos E, Mill J (2019). A ZEBRAFISH MODEL OF CLOZAPINE EXPOSURE: DRUG-INDUCED TRANSCRIPTOMIC CHANGES IN THE BRAIN. Author URL.
Jeffries A, Bray N, O'Neill P, Poschmann J, Hannon E, Mill J (2019). ALTERNATIVE SPLICING AND ISOFOROM DIVERSITY IN THE DEVELOPING BRAIN: RELEVANCE FOR NEUROPSYCHIATRIC DISEASE. Author URL.
Hannon E, Dempster E, Burrage J, McQuillin A, St Clair D, Morris D, Di Forti M, Gaughran F, MacCabe J, Breen G, et al (2019). AN INTEGRATED GENETIC-EPIGENETIC ANALYSIS OF SCHIZOPHRENIA: EVIDENCE FOR CO-LOCALIZATION OF GENETIC ASSOCIATIONS AND DIFFERENTIAL DNA METHYLATION FROM a LARGE META-ANALYSIS OF WHOLE BLOOD DNA. Author URL.
Di Forti M, Dempster E, Quattrone D, Hannon E, Burrage J, Mansell G, Rutten B, van Os J, O'Donovan M, Richards A, et al (2019). CAN DNA METHYLATION PROFILING SHED LIGHT ON THE BIOLOGY OF CANNABIS ASSOCIATED PSYCHOSIS? PRELIMINARY DATA ON THE EWAS CANNABIS USE SIGNATURE IN THE EUGEI CASE-CONTROL STUDY. Author URL.
Wong CCY, Smith RG, Hannon E, Assary E, Parikshak N, Prabhakar S, Geschwind D, Mill J (2019). CONVERGENT METHYLOMIC SIGNATURES BETWEEN AUTISM ASSOCIATED WITH DUPLICATIONS OF CHROMOSOME 15Q AND IDIOPATHIC AUTISM. Author URL.
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Relton C, Mill J, Fisher H (2019). DNA METHYLATION AND ADOLESCENT TRAJECTORIES OF PSYCHOTIC SYMPTOMS. Author URL.
Crawford B, Craig Z, Mansell G, White I, Smith A, Spaull S, Imm J, Hannon E, Wood A, Yaghootkar H, et al (2019). DNA METHYLATION AND INFLAMMATION MARKER PROFILES ASSOCIATED WITH a HISTORY OF DEPRESSION. Author URL.
Kandaswamy R, Hannon E, Mansell G, Williams B, Burrage J, Roberts S, Danese A, Mill J, Arseneault L, Fisher H, et al (2019). DNA METHYLOME MARKS OF EXPOSURE TO PSYCHOSOCIAL STRESS DURING ADOLESCENCE: ANALYSIS OF a NOVEL LONGITUDINAL MZ DISCORDANT TWIN STUDY. Author URL.
O'Brien H, Hannon E, Hill M, Toste C, Robertson M, Morgan J, McLaughlin G, Lewis C, Schalkwyk L, Pardinas A, et al (2019). EXPRESSION QUANTITATIVE TRAIT LOCI IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN NEUROPSYCHIATRIC DISORDERS. Author URL.
Viana J, Mansell G, Jager A, Mogavero F, Walker S, Huzard D, Zoratto F, Macri S, Hannon E, Laviola G, et al (2019). GENETIC AND EPIGENETIC SIGNATURES OF AGGRESSION IN THREE DISTINCT RODENT MODELS. Author URL.
Hannon E, Marzi S, Schalkwyk L, Mill J (2019). GENETIC RISK VARIANTS FOR BRAIN DISORDERS ARE SIGNIFICANTLY ENRICHED IN ACTIVE ENHANCERS IN THE CORTEX. Author URL.
Jones CS, Dbeis R, McDermott FD, Burrage J, Hannon E, Shireby G, Knight B, Saunders S, Chandler I, Knox O, et al (2019). Genome Wide Study of DNA Methylation in Blood and Tissues of Patients with Rectal Cancer: Novel Findings, Validation and Replication. Author URL.
Policicchio S, Davies J, Choiza B, Hannon E, Burrage J, Dempster E, Mill J (2019). MAPPING CELL-TYPE SPECIFIC MARKERS OF GENOMIC REGULATION IN THE HUMAN BRAIN. Author URL.
Pishva E, van Amelsvoort T, Hannon E, Evers LJM, Mill J, Dempster E (2019). METHYLOMIC ANALYSIS OF SCHIZOPHRENIA IN 22Q11.2 DELETION SYNDROME. Author URL.
Hannon E, Dempster E, Mansell G, Schalkwyk L, Murray R, McQuillin A, Kowalec K, St Clair D, Morris D, Sullivan P, et al (2019). METHYLOMIC BIOMARKERS OF SCHIZOPHRENIA AND ANTIPSYCHOTIC MEDICATION EXPOSURE. Author URL.
Shireby G, Hannon E, Dempster E, Francis P, Lunnon K, Walker E, Mill J (2019). METHYLOMIC CONSEQUENCES OF POLYGENIC BURDEN FOR NEUROPSYCHIATRIC, NEURODEGENERATIVE AND NEUROLOGICAL DISORDERS. Author URL.
Hannon E, Bray N, Weedon M, Gorrie-Stone T, Smart M, Kumari M, Schalkwyk L, O'Donovan M, Mill J (2019). PLEIOTROPIC EFFECTS OF GENETIC VARIATION ASSOCIATED WITH PSYCHIATRIC DISORDERS ON DNA METHYLATION. Author URL.
Kowalec K, Hannon E, Mansell G, Burrage J, Mill J, Sullivan P (2019). PREDICTION OF MORTALITY USING DNA METHYLATION AGE IN SCHIZOPHRENIA. Author URL.
Shireby G, Hannon E, Francis P, Lunnon K, Dempster E, Walker E, Mill J (2019). RECALIBRATING THE EPIGENETIC CLOCK: APPLICATIONS FOR ASSESSING BIOLOGICAL AGEING IN THE HUMAN BRAIN. Author URL.
Mill J, Hannon E, Spiers H, Wong CCY, Viana J, O'Donovan M, Schalkwyk L, Bray N (2019). REGULATORY GENOMIC VARIATION IN THE DEVELOPING BRAIN: RELEVANCE TO NEUROPSYCHIATRIC PHENOTYPES. Author URL.
Policicchio S, Viana J, Iatrou A, Hannon E, Burrage J, Turecki G, Kaminsky Z, Mill J, Dempster E, Murphy T, et al (2019). SUICIDE-ASSOCIATED DNA METHYLATION CHANGES IN POST-MORTEM BRAIN SAMPLES: a META-ANALYSIS. Author URL.
O'Brien H, Hannon E, Spiers H, Jeffries A, McLaughlin G, Davies W, Anney R, Hill M, O'Donovan M, Mill J, et al (2019). TRANSCRIPTOMIC STUDIES OF THE HUMAN PRENATAL BRAIN. Author URL.
Hannon E, Dempster E, Burrage J, Curtis C, Gillespie A, Dempster D, Gunasinghe C, Schalkwyk L, Gaughran F, Murray R, et al (2017). AN EPIGENOME-WIDE ASSOCIATION STUDY OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA. Author URL.
Hannon E, Lunnon K, Schalkwyk L, Mill J (2017). CHARACTERIZING INTER-INDIVIDUAL VARIATION IN DNA METHYLATION BETWEEN BLOOD AND BRAIN: IMPLICATIONS FOR EPIGENETIC STUDIES OF PSYCHIATRIC PHENOTYPES. Author URL.
Roberts S, Suderman M, Zammit S, Watkins SH, Hannon E, Relton C, Mill J, Fisher HL (2017). DNA methylation and adolescent trajectories of psychotic symptoms. Author URL.
Sadahiro R, Bridget K, Smart N, Charity J, Jeffries A, Burrage J, Hannon E, Dempster E, Murphy T, Lunnon K, et al (2017). EPIGENETIC ALTERATIONS THROUGH SURGERY AND POSTOPERATIVE DELIRIUM: PILOT STUDY. Author URL.
van Dongen J, Suderman M, Sugden K, Ismail K, Mulder RH, Kupper LK, Bustamante M, Alemany S, Bonder MJ, Parmar P, et al (2017). Epigenome-wide association study meta-analysis of aggressive behavior. Author URL.
Murphy T, Dempster E, Hannon E, Burrage J, Turecki G, Mill J (2017). GENOME-WIDE METHYLATION ANALYSIS IN THE BRAINS OF DEPRESSED SUICIDE COMPLETERS. Author URL.
Dempster E, Hannon E, Schalkwyk L, Bohlken M, Kaprio J, Toulopoulou T, Spector T, Hulshoffpol H, Nenadic I, Cannon T, et al (2017). GENOME-WIDE METHYLOMIC ANALYSIS OF MONOZYGOTIC TWINS DISCORDANT FOR SCHIZOPHRENIA. Author URL.
Viana J, Pidsley R, Hannon E, Spiers H, Troakes C, Al-Saraj S, Mechawar N, Turecki G, Schalkwyk L, Bray NJ, et al (2017). INVESTIGATING EPIGENOMIC REGULATION IN SCHIZOPHRENIA. Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA. Author URL.
Gillespie A, Hannon E, Dempster E, Collier D, Egerton A, Mill J, MacCabe J (2017). LONGITUDINAL EPIGENETIC ANALYSIS OF CLOZAPINE USE IN TREATMENT-RESISTANT SCHIZOPHRENIA: DATA FROM THE CRESTAR CONSORTIUM. Author URL.
Hannon E, Spiers H, Viana J, Pidsley R, Burrage J, Murphy T, Troakes C, Turecki G, O'Donovan M, Schalkwyk L, et al (2017). METHYLATION QUANTITATIVE TRAIT LOCI (MQTL) IN THE DEVELOPING HUMAN BRAIN AND THEIR ENRICHMENT IN GENOMIC REGIONS ASSOCIATED WITH SCHIZOPHRENIA. Author URL.
Jeffries A, Hannon E, Dempster E, Burrage J, Evans D, Collier D, Mill J (2017). METHYLOME CELLULAR SIGNATURES INDUCED BY ACUTE EXPOSURE TO TWELVE ANTIPSYCHOTIC AND NEUROTRANSMITTER DRUGS. Author URL.
Wong CCY, Parikshak N, Spiers H, Brays NJ, Lysenko L, Troakes C, Viana J, Hannon E, Schalkwyk L, Geschwind D, et al (2017). METHYLOMIC ANALYSIS OF AUTISM BRAIN: DISEASE ASSOCIATED VARIATION AND SUPPORT FOR a NEURODEVELOPMENTAL COMPONENT TO ETIOLOGY. Author URL.
Kuzma E, Hannon E, Zhou A, Lourida I, Bethel A, Levine D, Lunnon K, Thompson‐Coon J, Hyppönen E, Llewellyn DJ, et al (2017). [P3–529]: a SYSTEMATIC REVIEW OF MENDELIAN RANDOMIZATION STUDIES INVESTIGATING CAUSAL ASSOCIATIONS BETWEEN RISK FACTORS AND DEMENTIA.
van Dongen J, Ismail K, Mulder R, Baselmans B, Nivard M, Jansen R, Ligthart L, Ollikainen M, Vuoksimaa E, Tiemeier H, et al (2016). Epigenome-wide association study meta-analysis of aggressive behavior. Author URL.
Lunnon K, Smith R, Hannon E, Smith A, Schalkwyk LC, Haroutunian V, Mill J (2015). O3‐05‐01: Systems‐level evidence for epigenetic dysfunction in Alzheimer's disease.
Lunnon K, Smith R, Hannon E, Volta M, Troakes C, Haroutunian V, Katsel P, Al‐Sarraj S, Lovestone S, Schalkwyk L, et al (2014). O3‐04‐03: CROSS‐TISSUE METHYLOMIC PROFILING IN ALZHEIMER'S DISEASE.
Hannon E, Pocklington A, Holmans P, O'Donovan M (2012). Analysis of gene expression patterns in foetal brains with schizophrenia and bipolar GWAS data. Author URL.
MANASIA A, OROPELLO J, LEIBOWITZ A, HANNON E, LU Y, BENJAMIN E (1993). MESENTERIC VENOUS LEVELS OF GLUTATHIONE DISULFIDE (GSSG) IN PORCINE HEMORRHAGIC-SHOCK AND REPERFUSION. Author URL.
