Prof David Strain
Associate Professor
D.Strain@exeter.ac.uk
01392403058
Diabetes and Vascular Research Centre
Overview
Prof David Strain is an Associate Professor of Cardiometabolic Health at the University of Exeter Medical School, an honorary consultant in medicine for the older adult, Head of the academic department for healthcare for older adults and the chair of the British Medical Association’s Board of Science. Clinically, he runs a community diabetes service for the older adult, works as an in-patient stroke consultant, and participates in the chronic fatigue service. Prior to this, Dr Strain studied at Liverpool University before completing his Doctorate in Medicine on ‘Ethnic differences in the vascular responses to insulin resistance’ at the International Centre for Cardiovascular Health, Imperial College, London.
His main research focus is the health of older adults with diabetes; ensuring the right patient gets the right treatment. This includes research across the spectrum from mechanistic studies in the biologically young to pragmatic trials in the frail elderly population. He has an expertise in exploring the mechanism that some medications give benefits for people with diabetes beyond their effect on sugar and blood pressure, to determine if we can better select the medication for each patient. He has performed the only study to date demonstrating the feasibility of individualizing targets for older adults across Europe. This has informed the new UK guidance document for the management of older adults with diabetes and frailty, of which he was lead author. Within this remit, he engages in multidisciplinary research portfolio, supervising renal physicians, cardiologists, radiographers, basic scientists as well as geriatricians.
His role in global drug development advisory boards, and ability to translate complex mechanisms using readily interpretable analogies has earned him a global reputation for providing relevant comprehensible lectures. As a result he has presented his work in over 110 countries, including USA, Canada, across Europe, the Middle East, India, Latin America, Africa, China, Russia and Australasia
Since March 2020, he has been heavily involved in the COVID-19 response team. Within the BMA he has led the academic response to risk assessment of healthcare workers and been responsible for several briefing statements such as position statement on face masks and covid late complications, whilst clinically he is the Clinical Lead for COVID services at the Royal Devon & Exeter NHS Foundation Trust. He has participated in the NHS long COVID Taskforce, has given evidence at the All-Party Parliamentary Group long COVID meetings, and has presented at several meetings including the Society of Occupational Medicine, the Westminster Health Policy and is part of the Board of Science's organisational committee
Qualifications
MB ChB, Liverpool
BSc(Hons)
FRCP
MD (London)
Research group links
Publications
Journal articles
Strain W, Griffiths J (In Press). A systematic review and meta-analysis of the impact of GLP-1 receptor agonists and SGLT-2 inhibitors on cardiovascular outcomes in biologically healthy older adults. The British Journal of Diabetes
Strain W, Down S, Brown P, Puttanna A, Sinclair A (In Press). Diabetes and Frailty: an Expert Consensus Statement on the Management of Older Adults with Type 2 Diabetes. Diabetes Therapy
Strain WD, Paldanius PM (In Press). Dipeptidyl Peptidase-4 Inhibitor Development and Post-authorisation Programme for Vildagliptin. European Endocrinology
Strain W (In Press). Effects of semaglutide on stroke subtypes in type 2 diabetes: post hoc analysis of the randomised SUSTAIN 6 & PIONEER 6. Stroke, 53 Abstract.
Rinaldi G (In Press). Epidemiological Model Based Periodic Intervention Policies
for COVID-19 Mitigation in the United Kingdom. Nature Scientific Reports
Zirk-Sadowski J, Masoli J, Strain WD, Delgado J, Henley W, Hamilton W, Melzer D, Ble A (In Press). Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients. The American Journal of Gastroenterology (Elsevier)
evans M, Morgan A, Davies S, beba H, Strain W (In Press). The role of Sodium-glucose co-transporter-2 (SGLT2) inhibitors in frail older adults with or without type 2 diabetes mellitus (T2DM). Age and Ageing
Strain WD, Morgan A, Evans M (In Press). The value of insulin degludec in frail older adults with type 2 diabetes. Diabetes Therapy
Casanova F, Gooding K, Shore A, Adingupu D, Mawson D, Ball C, Anning C, Aizawa K, Gates P, Strain W, et al (In Press). Weight change and sulphonylurea therapy are related to three-year change in microvascular function in people with type 2 diabetes. Diabetologia
Davies AP, McKinley R, Gabbay M, Katz D, Strain WD (2024). Clinical academics' experiences of REF2021. Clin Med (Lond), 24(1). Abstract. Author URL.
Bland D, Evans R, Binesmael A, Wood S, Qureshi SP, Fearnley K, Small A, Strain WD, Agius R (2024). Post-acute COVID-19 complications in UK doctors: results of a cross-sectional survey. Occup Med (Lond), 74(1), 99-103. Abstract. Author URL.
van der Feltz-Cornelis C, Turk F, Sweetman J, Khunti K, Gabbay M, Shepherd J, Montgomery H, Strain WD, Lip GYH, Wootton D, et al (2024). Prevalence of mental health conditions and brain fog in people with long COVID: a systematic review and meta-analysis. General Hospital Psychiatry, 88, 10-22.
Allan L, O'Connell A, Raghuraman S, Bingham A, Laverick A, Chandler K, Connors J, Jones B, Um J, Morgan-Trimmer S, et al (2023). A rehabilitation intervention to improve recovery after an episode of delirium in adults over 65 years (RecoverED): study protocol for a multi-centre, single-arm feasibility study. Pilot Feasibility Stud, 9(1). Abstract. Author URL.
Strain WD, Davies S, Chowdhury S (2023). Long COVID and myalgic encephalomyelitis: opportunities for understanding and research. British Journal of Healthcare Management, 29(6), 1-3.
Alwan NA, Clutterbuck D, Pantelic M, Hayer J, Fisher L, Hishmeh L, Heightman M, Allsopp G, Wootton D, Khan A, et al (2023). Long Covid active case finding study protocol: a co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways). PLoS ONE, 18(7 July). Abstract.
Hopkinson NS, Stokes-Lampard H, Clarke S, James A, Hawthorne K, Thakar R, Fenton K, Strain D, Walton G, Cullen P, et al (2023). Meagre spending on tobacco control is costing the economy billions. BMJ-BRITISH MEDICAL JOURNAL, 381 Author URL.
Van der Feltz-Cornelis CM, Moriarty AS, Strain WD (2023). Neurological Dysfunction in Long COVID Should Not be Labelled as Functional Neurological Disorder. Viruses, 15(3), 783-783. Abstract.
Turk F, Sweetman J, Allsopp G, Crooks M, Cuthbertson DJ, Gabbay M, Hishmeh L, Lip GYH, Strain WD, Williams N, et al (2023). Pathways to care for Long COVID and for long-term conditions from patients' and clinicians' perspective. J Evid Based Med, 16(4), 435-437. Author URL.
Yu D, Brown J, David Strain W, Simmons D (2023). Real-world evidence that among atrial fibrillation patients warfarin is associated with reduced nonelective admissions compared with those on DOACs. Clin Cardiol, 46(12), 1544-1553. Abstract. Author URL.
Forshaw D, Wall EC, Prescott G, Dehbi H-M, Green A, Attree E, Hismeh L, Strain WD, Crooks MG, Watkins C, et al (2023). STIMULATE-ICP: a pragmatic, multi-centre, cluster randomised trial of an integrated care pathway with a nested, Phase III, open label, adaptive platform randomised drug trial in individuals with Long COVID: a structured protocol. PLoS One, 18(2). Abstract. Author URL.
Phillips GA, Butchart J, Hope S, Taylor G, Strain WD (2023). Salivary beta amyloid 1‐42 (Aβ42) for the diagnosis of Alzheimer’s disease: a systematic review and meta‐analysis. Alzheimer's & Dementia, 19(S15).
Williams J, Gilchrist M, Strain WD, Fraser D, Shore A (2022). 24-h Glycaemic profiles in peritoneal dialysis patients and non-dialysis controls with advanced kidney disease. Perit Dial Int, 42(5), 497-504. Abstract. Author URL.
Evans M, Lewis RD, Morgan AR, Whyte MB, Hanif W, Bain SC, Davies S, Dashora U, Yousef Z, Patel DC, et al (2022). A Narrative Review of Chronic Kidney Disease in Clinical Practice: Current Challenges and Future Perspectives. Adv Ther, 39(1), 33-43. Abstract. Author URL.
Williams J, Gilchrist M, Strain WD, Fraser D, Shore A (2022). An exploratory study of the relationship between systemic microcirculatory function and small solute transport in incident peritoneal dialysis patients. Perit Dial Int, 42(5), 513-521. Abstract. Author URL.
Evans M, Morgan AR, Bain SC, Davies S, Dashora U, Sinha S, Seidu S, Patel DC, Beba H, Strain WD, et al (2022). Defining the Role of SGLT2 Inhibitors in Primary Care: Time to Think Differently. Diabetes Ther, 13(5), 889-911. Abstract. Author URL.
Thompson J, Nnate D, Mussad M, Carroll S, Buck P, Strain W, Banerjee A, Van de Velde N (2022). EPH155 a Systematic Review of the Impact of Vaccination on Long COVID. Value in Health, 25(12).
Heath R, Johnsen H, Strain WD, Evans M (2022). Emerging Horizons in Heart Failure with Preserved Ejection Fraction: the Role of SGLT2 Inhibitors. Diabetes Ther, 13(2), 241-250. Abstract. Author URL.
Evans M, Morgan AR, Bain SC, Davies S, Hicks D, Brown P, Yousef Z, Dashora U, Viljoen A, Beba H, et al (2022). Meeting the Challenge of Virtual Diabetes Care: a Consensus Viewpoint on the Positioning and Value of Oral Semaglutide in Routine Clinical Practice. Diabetes Ther, 13(2), 225-240. Abstract. Author URL.
Evans M, Morgan AR, Whyte MB, Hanif W, Bain SC, Kalra PA, Davies S, Dashora U, Yousef Z, Patel DC, et al (2022). New Therapeutic Horizons in Chronic Kidney Disease: the Role of SGLT2 Inhibitors in Clinical Practice. Drugs, 82(2), 97-108. Abstract. Author URL.
Khan F, Gonçalves I, Shore AC, Natali A, Palombo C, Colhoun HM, Östling G, Casanova F, Kennbäck C, Aizawa K, et al (2022). Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis. Cell Rep Med, 3(7). Abstract. Author URL.
Alghamdi F, Owen R, Ashton REM, Obotiba AD, Meertens RM, Hyde E, Faghy MA, Knapp KM, Rogers P, Strain WD, et al (2022). Post-acute COVID syndrome (long COVID): What should radiographers know and the potential impact for imaging services. Radiography, 28, S93-S99.
Strain D (2022). Removing special covid leave will only undervalue staff and threaten patient safety. The BMJ
van der Feltz-Cornelis CM, Sweetman J, Allsopp G, Attree E, Crooks MG, Cuthbertson DJ, Forshaw D, Gabbay M, Green A, Heightman M, et al (2022). STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol. PLoS ONE, 17(11). Abstract.
Strain WD, Sherwood O, Banerjee A, Van der Togt V, Hishmeh L, Rossman J (2022). The Impact of COVID Vaccination on Symptoms of Long COVID: an International Survey of People with Lived Experience of Long COVID. Vaccines, 10(5). Abstract.
Shiri T, Evans M, Talarico CA, Morgan AR, Mussad M, Buck PO, McEwan P, Strain WD (2022). The Population-Wide Risk-Benefit Profile of Extending the Primary COVID-19 Vaccine Course Compared with an mRNA Booster Dose Program. Vaccines, 10(2), 140-140. Abstract.
He J, Bellenger NG, Ludman AJ, Shore AC, Strain WD (2022). Treatment of myocardial ischaemia-reperfusion injury in patients with ST-segment elevation myocardial infarction: promise, disappointment, and hope. Rev Cardiovasc Med, 23(1). Abstract. Author URL.
Strain WD, Mansi J, Boikos C, Boivin M, Fisher WA (2021). Achieving Influenza Vaccine Uptake Target in Canada via a Pharmacy-Led Telephone Discussion during the 2019-2020 Season. Vaccines (Basel), 9(4). Abstract. Author URL.
Geriatric Medicine Research Collaborative, Covid Collaborative, Welch C (2021). Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study. Age Ageing, 50(3), 617-630. Abstract. Author URL.
Aizawa K, Gates PE, Mawson DM, Elyas S, Casanova F, Gooding KM, Adingupu DD, Strain WD, Shore AC (2021). Carotid–femoral pulse wave velocity acquisition methods and their associations with cardiovascular risk factors and subclinical biomarkers of vascular health. Journal of Hypertension, 40(4), 658-665. Abstract.
Elyas S, Adingupu D, Aizawa K, Casanova F, Gooding K, Fulford J, Mawson D, Gates PE, Shore AC, Strain D, et al (2021). Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets. Aging, 13(18), 22030-22039.
Strain WD, Paldánius PM (2021). Correction to: Diabetes, cardiovascular disease and the microcirculation (Cardiovascular Diabetology, (2018), 17, 1, (57), 10.1186/s12933-018-0703-2). Cardiovascular Diabetology, 20(1). Abstract.
Strain WD, Jankowski J, Davies AP, English P, Friedman E, McKeown H, Sethi S, Rao M (2021). Development and presentation of an objective risk stratification tool for healthcare workers when dealing with the COVID-19 pandemic in the UK: risk modelling based on hospitalisation and mortality statistics compared with epidemiological data. BMJ Open, 11(9), e042225-e042225. Abstract.
Al-Shahi Salman R, Dennis MS, Sandercock PAG, Sudlow CLM, Wardlaw JM, Whiteley WN, Murray GD, Stephen J, Rodriguez A, Lewis S, et al (2021). Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage. JAMA Neurology, 78(10), 1179-1179.
Strain WD, Elyas S, Wedge N, Mounce L, Henley W, James M, Shore AC (2021). Evaluation of microalbuminuria as a prognostic indicator after a TIA or minor stroke in an outpatient setting: the prognostic role of microalbuminuria in TIA evolution (ProMOTE) study. BMJ Open, 11(9), e043253-e043253. Abstract.
Maskery MP, Holscher C, Jones SP, Price CI, Strain WD, Watkins CL, Werring DJ, Emsley HCA (2021). Glucagon-like peptide-1 receptor agonists as neuroprotective agents for ischemic stroke: a systematic scoping review. Journal of Cerebral Blood Flow and Metabolism, 41(1), 14-30. Abstract.
Meertens R, Knapp KM, Strain WD, Casanova F, Ball S, Fulford J, Thorn C (2021). In vivo Measurement of Intraosseous Vascular Haemodynamic Markers in Human Bone Tissue Utilising Near Infrared Spectroscopy. Frontiers in Physiology, 12 Abstract.
Aizawa K, Casanova F, Gates PE, Mawson DM, Gooding KM, Strain WD, Östling G, Nilsson J, Khan F, Colhoun HM, et al (2021). Reservoir-Excess Pressure Parameters Independently Predict Cardiovascular Events in Individuals with Type 2 Diabetes. Hypertension, 78(1), 40-50. Abstract.
Shiri T, Evans M, Talarico CA, Morgan AR, Mussad M, Buck PO, McEwan P, Strain WD (2021). Vaccinating Adolescents and Children Significantly Reduces COVID-19 Morbidity and Mortality across all Ages: a Population-Based Modeling Study Using the UK as an Example. Vaccines, 9(10), 1180-1180. Abstract.
Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract. Author URL.
Banerjee A, Benedetto V, Gichuru P, Burnell J, Antoniou S, Schilling RJ, Strain WD, Ryan R, Watkins C, Marshall T, et al (2020). Adherence and persistence to direct oral anticoagulants in atrial fibrillation: a population-based study. Heart, 106(2), 119-126. Abstract. Author URL.
Bain SC, Bakhai A, Evans M, Green A, Menown I, Strain WD (2020). An update to: Pharmacological treatment for type 2 diabetes integrating findings from cardiovascular outcome trials: an expert consensus in the UK. <i>Diabet Med</i> 2019; 36: 1063-1071. DIABETIC MEDICINE, 37(8), 1405-1407. Author URL.
Masoli JAH, Delgado J, Pilling L, Strain D, Melzer D (2020). Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality. Age Ageing, 49(5), 807-813. Abstract. Author URL.
Rao M, Strain WD, Jankowski J, Davies A, English PMB, Friedman E, McKeown H, Sethi S (2020). Development and Presentation of an Objective Risk Stratification Tool for healthcare workers when dealing with the COVID-19 pandemic in the UK: Risk modelling based on hospitalisation and mortality statistics compared to epidemiological data. Abstract.
Strain WD, Paldánius PM (2020). Effect of clinical inertia and trial participation in younger and older adults with diabetes having comorbidities and progressive complications. Diabetes Research and Clinical Practice, 166 Abstract.
Williams J, Gilchrist M, Fraser D, Strain D, Shore A (2020). P1161CUTANEOUS MICROCIRCULATORY DYSFUNCTION IN PERITONEAL DIALYSIS PATIENTS. Nephrology Dialysis Transplantation, 35(Supplement_3).
Aizawa K, Casanova F, Mawson D, Gooding K, Elyas S, Adingupu D, Strain D, Gates P, Shore A (2020). P17 Comparisons of Carotid-femoral Pulse Wave Velocity Obtained from the Surface-distance Measurement and from the Population-derived Distance Formula: Associations with Macro- and Microvascular Alterations in Older Adults. Artery Research, 25(Suppl 1), s60-s60.
McKenzie CA, Page VJ, Strain WD, Blackwood B, Ostermann M, Taylor D, Spronk PE, McAuley DF (2020). Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol. Syst Rev, 9(1). Abstract. Author URL.
Bowman K, Jones L, Masoli J, Mujica-Mota R, Strain D, Butchart J, Valderas JM, Fortinsky RH, Melzer D, Delgado J, et al (2020). Predicting incident delirium diagnoses using data from primary-care electronic health records. Age Ageing, 49(3), 374-381. Abstract. Author URL.
Macdougall C, Dangerfield P, Katz D, Strain WD (2020). The impact of COVID-19 on Medical education and Medical Students. How and when can they return to placements?. MedEdPublish, 9, 159-159. Abstract.
Albury C, Strain WD, Brocq SL, Logue J, Lloyd C, Tahrani A, Language Matters working group (2020). The importance of language in engagement between health-care professionals and people living with obesity: a joint consensus statement. Lancet Diabetes Endocrinol, 8(5), 447-455. Abstract. Author URL.
Williams J, Gilchrist M, Strain D, Fraser D, Shore A (2020). The systemic microcirculation in dialysis populations. Microcirculation, 27(5). Abstract. Author URL.
Strain WD, Tsang C, Hurst M, McEwan P, Unadkat M, Meadowcroft S, Shardlow R, Evans M (2020). What Next After Metformin in Type 2 Diabetes? Selecting the Right Drug for the Right Patient. DIABETES THERAPY, 11(6), 1381-1395. Author URL.
Strain D, Kar P (2019). 'One-size-fits-all' treatment targets harm frail older patients with diabetes. Clinical Pharmacist, 11(5).
PALDÁNIUS PM, STRAIN WD (2019). 1276-P: Effect of Trial Participation on Metabolic Parameters in People with Progressive Diabetic Complications. Diabetes, 68(Supplement_1).
Masoli J, Correa Delgado J, Bowman K, Strain W, Henley W, Melzer D (2019). Association of blood pressure with clinical outcomes in older adults with chronic kidney disease. Age and Ageing
RESTART Collaboration (2019). Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial. Lancet, 393(10191), 2613-2623. Abstract. Author URL.
Al-Shahi Salman R, Minks DP, Mitra D, Rodrigues MA, Bhatnagar P, du Plessis JC, Joshi Y, Dennis MS, Murray GD, Newby DE, et al (2019). Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial. Lancet Neurol, 18(7), 643-652. Abstract. Author URL.
Dennis M, Mead G, Forbes J, Graham C, Hackett M, Hankey GJ, House A, Lewis S, Lundström E, Sandercock P, et al (2019). Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial. The Lancet, 393(10168), 265-274. Abstract.
Bain SC, Bakhai A, Evans M, Green A, Menown I, Strain WD (2019). Pharmacological treatment for Type 2 diabetes integrating findings from cardiovascular outcome trials: an expert consensus in the UK. Diabet Med, 36(9), 1063-1071. Abstract. Author URL.
Strain WD, McEwan P, Howitt H, Meadowcroft S (2019). Retrospective Database Analysis Evaluating the Clinical Outcomes of Changing Treatment of People with Type 2 Diabetes Mellitus (T2DM) from Other DPP-4 Inhibitor Therapy to Alogliptin in a Primary Care Setting. Diabetes Ther, 10(4), 1499-1507. Abstract. Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Östling G, Khan F, Colhoun HM, Palombo C, et al (2018). 3.2 Reservoir Pressure Integral is Independently Associated with the Reduction in Renal Function in an Older Population. Artery Research, 24(1), 72-73.
van Zuydam NR, Ahlqvist E, Sandholm N, Deshmukh H, Rayner NW, Abdalla M, Ladenvall C, Ziemek D, Fauman E, Robertson NR, et al (2018). A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects with Type 2 Diabetes. Diabetes, 67(7), 1414-1427. Abstract. Author URL.
Strain WD, Paldánius PM (2018). Diabetes, cardiovascular disease and the microcirculation. Cardiovasc Diabetol, 17(1). Abstract. Author URL.
Gates PE, Gurung A, Mazzaro L, Aizawa K, Elyas S, Strain WD, Shore AC, Shandas R (2018). Measurement of Wall Shear Stress Exerted by Flowing Blood in the Human Carotid Artery: Ultrasound Doppler Velocimetry and Echo Particle Image Velocimetry. Ultrasound Med Biol, 44(7), 1392-1401. Abstract. Author URL.
Zirk-Sadowski J, Masoli JA, Delgado J, Hamilton W, Strain WD, Henley W, Melzer D, Ble A (2018). Proton-Pump Inhibitors and Long-Term Risk of Community-Acquired Pneumonia in Older Adults. J Am Geriatr Soc, 66(7), 1332-1338. Abstract. Author URL.
Soto C, Strain WD (2018). Tackling clinical inertia: Use of coproduction to improve patient engagement. J Diabetes, 10(12), 942-947. Abstract. Author URL.
Al-Shahi Salman R, Dennis MS, Murray GD, Innes K, Drever J, Dinsmore L, Williams C, White PM, Whiteley WN, Sandercock PAG, et al (2018). The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: Study protocol for a randomised controlled trial. Trials, 19(1). Abstract.
Strain WD, Hope SV, Green A, Kar P, Valabhji J, Sinclair AJ (2018). Type 2 diabetes mellitus in older people: a brief statement of key principles of modern day management including the assessment of frailty. A national collaborative stakeholder initiative. Diabet Med, 35(7), 838-845. Abstract. Author URL.
Meertens RM, Casanova F, Knapp KM, Thorn C, Strain WD (2018). Use of Near-Infrared Systems for Investigations of Hemodynamics in Human in Vivo Bone Tissue: a Systematic Review. Journal of Orthopaedic Research
Strain WD, Cos X, Prünte C (2017). Considerations for management of patients with diabetic macular edema: Optimizing treatment outcomes and minimizing safety concerns through interdisciplinary collaboration. Diabetes Res Clin Pract, 126, 1-9. Abstract. Author URL.
Strain WD, Paldánius PM (2017). Dipeptidyl Peptidase-4 Inhibitor Development and Post-authorisation Programme for Vildagliptin – Clinical Evidence for Optimised Management of Chronic Diseases Beyond Type 2 Diabetes. European Endocrinology, 13(02), 62-62. Abstract.
Gurung A, Gates PE, Mazzaro L, Fulford J, Zhang F, Barker AJ, Hertzberg J, Aizawa K, Strain WD, Elyas S, et al (2017). Echo Particle Image Velocimetry for Estimation of Carotid Artery Wall Shear Stress: Repeatability, Reproducibility and Comparison with Phase-Contrast Magnetic Resonance Imaging. Ultrasound Med Biol, 43(8), 1618-1627. Abstract. Author URL.
strain WD, Abhijit A, Paldanius PM (2017). Individualizing treatment targets for elderly patients with type 2 diabetes: factors influencing clinical decision making in the 24-week, randomized INTERVAL study. Aging
Hope SV, Knight BA, Shields BM, Hill AV, Choudhary P, Strain WD, McDonald TJ, Jones AG (2017). Random non-fasting C-peptide testing can identify patients with insulin-treated type 2 diabetes at high risk of hypoglycaemia. Diabetologia
Ziemssen F, Cruess A, Dunger-Baldauf C, Margaron P, Snow H, Strain WD (2017). Ranibizumab in Diabetic Macular Oedema – a Benefit–risk Analysis of Ranibizumab 0.5 mg PRN Versus Laser Treatment. European Endocrinology, 13(02), 91-91. Abstract.
Epstein KA, Viscoli CM, Spence JD, Young LH, Inzucchi SE, Gorman M, Gerstenhaber B, Guarino PD, Dixit A, Furie KL, et al (2017). Smoking cessation and outcome after ischemic stroke or TIA. Neurology, 89(16), 1723-1729. Abstract. Author URL.
Casanova F, Adingupu DD, Adams F, Gooding KM, Looker HC, Aizawa K, Dove F, Elyas S, Belch JJF, Gates PE, et al (2017). The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control. Cardiovasc Diabetol, 16(1). Abstract. Author URL.
Vencio S, Paldánius PM, Blüher M, Giannella-Neto D, Caiado-Vencio R, Strain WD (2017). Understanding the barriers and improving care in type 2 diabetes: Brazilian perspective in time to do more in diabetes. Diabetology and Metabolic Syndrome, 9(1). Abstract.
Strain WD, Smith C (2016). Cardiovascular Outcome Studies in Diabetes: How Do We Make Sense of These New Data?. Diabetes Ther, 7(2), 175-185. Abstract. Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Shore AC, Strain WD, Gates PE (2016). Echogenicity of the Common Carotid Artery Intima-Media Complex in Stroke. Ultrasound Med Biol, 42(5), 1130-1137. Abstract. Author URL.
Williams J, Gilchrist M, Strain D (2016). Glucose dysregulation and its effect on peritoneal dialysis patients. Journal of Kidney Care, 1(2), 58-61.
Elyas S, Shore AC, Kingwell H, Keenan S, Boxall L, Stewart J, James MA, Strain WD (2016). Microalbuminuria could improve risk stratification in patients with TIA and minor stroke. Ann Clin Transl Neurol, 3(9), 678-683. Abstract. Author URL.
Delgado J, Masoli JAH, Bowman K, Strain WD, Kuchel GA, Walters K, Lafortune L, Brayne C, Melzer D, Ble A, et al (2016). Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals. Journal of the American Geriatrics Society, 65(5), 995-1003. Abstract.
Kernan WN, Viscoli CM, Furie KL, Young LH, Inzucchi SE, Gorman M, Guarino PD, Lovejoy AM, Peduzzi PN, Conwit R, et al (2016). Pioglitazone after Ischemic Stroke or Transient Ischemic Attack. New England Journal of Medicine, 374(14), 1321-1331.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Strain WD, Shore AC, Gates PE (2016). Reactivity to low-flow as a potential determinant for brachial artery flow-mediated vasodilatation. Physiol Rep, 4(12). Abstract. Author URL.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The Effects of Lumbar Sympathectomy on Bone and Soft Tissue Haemodynamics of the Leg recorded using Near Infrared Spectroscopy: a Case Report. Journal of Biomedical Engineering and Informatics, 3, 28-32.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu DD, Gooding KM, Strain WD, Park CM, Parker KH, Gates PE, et al (2016). [PP.11.05] RESERVOIR-PRESSURE ANALYSIS IN TYPE 2 DIABETES INDIVIDUALS WITH CARDIOVASCULAR DISEASE. Journal of Hypertension, 34(Supplement 2), e178-e178.
Jones LC, Strain WD, Sword J, Ostrowski C (2015). 53. THE CORRELATION BETWEEN PATIENTS, PATIENT'S RELATIVES AND HEALTHCARE PROFESSIONALS INTERPRETATION OF QUALITY OF LIFE - a PROSPECTIVE STUDY. Age and Ageing, 44(suppl 1), i16-i16.
Meertens RM, Strain WD, Knapp KM (2015). A Review of the Mechanisms, Diagnosis and Preventative Treatment of Osteoporotic Fragility Fractures in Patients with Type 2 Diabetes Mellitus. Journal of Endocrinology and Metabolism, Volume 5(Number 1-2), 157-162. Abstract.
Packer M, McMurray JJV, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, et al (2015). Angiotensin Receptor Neprilysin Inhibition Compared with Enalapril on the Risk of Clinical Progression in Surviving Patients with Heart Failure. Circulation, 131(1), 54-61. Abstract.
Adingupu DD, Thorn CE, Casanova F, Elyas S, Gooding K, Gilchrist M, Aizawa K, Gates PE, Shore AC, Strain DW, et al (2015). Blood Oxygen Saturation After Ischemia is Altered with Abnormal Microvascular Reperfusion. Microcirculation, 22(4), 294-305. Abstract. Author URL.
Elyas S, Adingupu D, Aizawa K, Shore AC, Strain WD, Gates PE (2015). Cerebral hemodynamics in patients with large vessel disease stroke and lacunar stroke. INTERNATIONAL JOURNAL OF STROKE, 10, 368-368. Author URL.
(2015). Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. The Lancet, 385(9968), 617-628.
Goncalves I, Bengtsson E, Colhoun HM, Shore AC, Palombo C, Natali A, Edsfeldt A, Dunér P, Fredrikson GN, Björkbacka H, et al (2015). Elevated Plasma Levels of MMP-12 Are Associated with Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects with Type 2 Diabetes. Arterioscler Thromb Vasc Biol, 35(7), 1723-1731. Abstract. Author URL.
Aizawa. K, Casanova F, Mawson D, Elyas S, Adingupu D, Gooding K, Strain D, Shore A, Gates P (2015). P3.5 TYPE 2 DIABETES EXACERBATES CAROTID ARTERY ECHOGENICITY AND CENTRAL ARTERY STIFFNESS IN MIDDLE-AGED AND OLDER INDIVIDUALS. Artery Research, 12(C), 11-11.
Palmer D, Strain WD, Webb B (2014). 242. Turning of the Tide: Does Tidemark Advancement Perpetuate Osteoarthritis. Rheumatology, 53(suppl_1), i150-i150.
McMurray JJV, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, et al (2014). Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure. New England Journal of Medicine, 371(11), 993-1004.
Strain WD, Blüher M, Paldánius P (2014). Clinical inertia in individualising care for diabetes: is there time to do more in type 2 diabetes?. Diabetes Ther, 5(2), 347-354. Abstract. Author URL.
McMurray JJV, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau J, Shi VC, Solomon SD, Swedberg K, et al (2014). Dual angiotensin receptor and neprilysin inhibition as an alternative to angiotensin‐converting enzyme inhibition in patients with chronic systolic heart failure: rationale for and design of the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failure trial (PARADIGM‐HF). European Journal of Heart Failure, 15(9), 1062-1073. Abstract.
McCluskey L, Jagger O, Strain WD (2014). Hypoglycemia associated with impaired mobility and diminished confidence in an elderly person with type 2 diabetes. Diabetic Hypoglycemia, 7(1), 11-14. Abstract.
Jones LC, Sword J, Strain WD, Ostrowski C (2014). P083: the correlation between patients, patient's relatives and healthcare professionals interpretation of quality of life – a prospective study. European Geriatric Medicine, 5, S108-S108.
Aizawa K, Elyas S, Adingpu D, Shore A, Strain D, Gates P (2014). P3.10 REACTIVITY TO LOW-FLOW IN THE BRACHIAL ARTERY: a POTENTIAL DETERMINANT FOR FLOW-MEDIATED DILATORY RESPONSE. Artery Research, 8(4), 138-138.
Strain WD, Cos X, Hirst M, Vencio S, Mohan V, Vokó Z, Yabe D, Blüher M, Paldánius PM (2014). Time to do more: addressing clinical inertia in the management of type 2 diabetes mellitus. Diabetes Res Clin Pract, 105(3), 302-312. Abstract. Author URL.
Gurung A, Mazzaro L, Gates PE, Strain D, Shore AC, Shandas R (2013). Abstract 246: Echo Particle Image Velocimetry Generates Wall Shear Stress Biomarkers with Higher Accuracy than Doppler: Clinical Studies on 24 Healthy and 12 Tia Subjects. Arteriosclerosis Thrombosis and Vascular Biology, 33(suppl_1).
Strain WD, Hughes AD, Mayet J, Wright AR, Kooner J, Chaturvedi N, Shore AC (2013). Attenuated systemic microvascular function in men with coronary artery disease is associated with angina but not explained by atherosclerosis. Microcirculation, 20(7), 670-677. Abstract. Author URL.
Gosling O, Morgan-Hughes G, Iyengar S, Strain W, Loader R, Shore A, Roobottom C (2013). Computed tomography to diagnose coronary artery disease: a reduction in radiation dose increases applicability. Clinical Radiology, 68(4), 340-345. Abstract.
Gosling O, Morgan-Hughes G, Iyengar S, Strain W, Loader R, Shore A, Roobottom C (2013). Computed tomography to diagnose coronary artery disease: a reduction in radiation dose increases applicability. Clin Radiol, 68(4), 340-345. Abstract. Author URL.
Hope SV, Strain WD (2013). Hypoglycemia in the elderly. Diabetic Hypoglycemia, 6(1), 3-10. Abstract.
Strain WD, Lukashevich V, Kothny W, Hoellinger MJ, Paldánius PM (2013). Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study. The Lancet, 382(9890), 409-416. Abstract.
Strain WD, Lukashevich V, Kothny W, Hoellinger M-J, Paldánius PM (2013). Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study. Lancet, 382(9890), 409-416. Abstract. Author URL.
Adingupu DD, Elyas S, Casanova F, Gates PE, Shore AC, Strain WD (2013). Microvascular autoregulatory response to ischaemia and pulse pressure. JOURNAL OF HUMAN HYPERTENSION, 27(10), 652-653. Author URL.
Adingupu DD, Thorn C, Casanova F, Elyas S, Gates PE, Strain WD, Shore AC (2013). Microvascular autoregulatory response to ischaemia in the skin and association with mean blood oxygen saturation. JOURNAL OF HUMAN HYPERTENSION, 27(10), 640-641. Author URL.
Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2013). P2.17 ECHOGENICITY OF THE COMMON CAROTID ARTERY INTIMA-MEDIA COMPLEX IN STROKE. Artery Research, 7(3-4), 123-123.
Elyas S, Adingupu D, Thorn C, Gates PE, Shore AC, Strain WD (2013). Skin microvascular function is impaired in patients with small vessel disease stroke but not in patients with large vessel disease stroke when compared to healthy controls. CEREBROVASCULAR DISEASES, 35, 521-521. Author URL.
Adingupu DD, Elyas S, Thorn CE, Gates PE, Shore AC, Strain WD (2013). The prevalence of abnormal microvascular response (peaks) in stroke or transient ischaemic attack (TIA) patients compared with Controls and association with impaired sympathetic activity. CEREBROVASCULAR DISEASES, 35, 547-547. Author URL.
Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2012). Brachial Artery Low Flow-Mediated Constriction in Individuals with Increased Cardiovascular Risk. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 44, 585-585. Author URL.
Foster J, Baillie PA, Strain WD (2012). Hypoglycemia precipitating prolonged QT interval and myocardial ischemia in a patient with coronary heart disease and renal failure. Diabetic Hypoglycemia, 4(3), 9-11. Abstract.
Park C, Bathula R, Shore AC, Tillin T, Strain WD, Chaturvedi N, Hughes AD (2012). Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors. Atherosclerosis, 221(2), 503-507. Abstract.
Park C, Bathula R, Shore AC, Tillin T, Strain WD, Chaturvedi N, Hughes AD (2012). Impaired post-ischaemic microvascular hyperaemia in Indian Asians is unexplained by diabetes or other cardiovascular risk factors. Atherosclerosis, 221(2), 503-507. Abstract. Author URL.
Strain WD, Adingupu DD, Shore AC (2012). Microcirculation on a large scale: techniques, tactics and relevance of studying the microcirculation in larger population samples. Microcirculation, 19(1), 37-46. Abstract. Author URL.
Aizawa K, Elyas S, Adingupu DD, Shore AC, Strain WD, Gates PE (2012). P4.17 INFLUENCE OF ESTIMATED WALL SHEAR RATE INDICES ON CAROTID ARTERY INTIMA-MEDIA THICKNESS AND INTIMA-MEDIA COMPLEX ECHOGENICITY. Artery Research, 6(4), 188-188.
Elyas S, Majekolagbe D, D'Abate F, Aizawa K, Gates PE, Shore AC, Strain WD (2012). PREVALENCE OF SKIN MICROVASCULAR AUTOREGULATORY DYSFUNCTION IN PATIENTS WHO SUFFER STROKE OR TIA COMPARED TO THE GENERAL POPULATION. AGE AND AGEING, 41, 81-81. Author URL.
Thompson D, Thornes J, Woods J, Khan A, Kreppel S, Palmer D, Phillips S, Shamsuddin N, Solman J, Strain WD, et al (2012). SODIUM DYSREGULATION AND ITS ASSOCIATION WITH MORTALITY. AGE AND AGEING, 41, 37-37. Author URL.
Shamsuddin N, Solman J, Khan A, Kreppel S, Palmer D, Phillips S, Thompson D, Thornes J, Woods J, Strain WD, et al (2012). THE RELATIONSHIP BETWEEN HYPONATRAEMIA AND LENGTH OF STAY IN ELDERLY CARE PATIENTS. AGE AND AGEING, 41, 42-42. Author URL.
(2012). The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. The Lancet, 379(9834), 2352-2363.
Aizawa K, Gates PE, Strain WD, Gosling OE, Mazzaro L, Zhang F, Barker AJ, Fulford J, Shore AC, Bellenger NG, et al (2011). Arterial Wall Shear Stress Measurement in Vivo Using Echo Particle Image Velocimetry (Echo PIV). MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 43(5), 743-744. Author URL.
Zhang F, Lanning C, Mazzaro L, Barker AJ, Gates PE, Strain WD, Fulford J, Gosling OE, Shore AC, Bellenger NG, et al (2011). In vitro and preliminary in vivo validation of echo particle image velocimetry in carotid vascular imaging. Ultrasound Med Biol, 37(3), 450-464. Abstract. Author URL.
Aizawa K, Elyas S, D’Abate F, Majekolagbe D, Shore AC, Strain WD, Gates PE (2011). P8.08 THE RELATIONSHIP BETWEEN BRACHIAL ARTERY FLOW-MEDIATED DILATION AND SHEAR RATE IN INDIVIDUALS WITH INCREASED CARDIOVASCULAR RISK. Artery Research, 5(4), 184-184.
Strain WD, Elyas S, Gates PE, Shore AC (2010). Age-related change in endothelial and microvessel function and therapeutic consequences. Reviews in Clinical Gerontology, 20(3), 161-170. Abstract.
Strain WD, Shore AC, Melzer D (2010). Albumin:creatinine ratio predicts mortality after stroke: analysis of the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc, 58(12), 2434-2435. Author URL.
Strain WD, Chaturvedi N, Hughes A, Nihoyannopoulos P, Bulpitt CJ, Rajkumar C, Shore AC (2010). Associations between cardiac target organ damage and microvascular dysfunction: the role of blood pressure. J Hypertens, 28(5), 952-958. Abstract. Author URL.
Strain WD, Hughes AD, Mayet J, Wright AR, Kooner J, Chaturvedi N, Shore AC (2010). Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent. BMC Cardiovasc Disord, 10 Abstract. Author URL.
Mahal S, Strain WD, Martinez-Perez ME, Thom SAM, Chaturvedi N, Hughes AD (2009). Comparison of the retinal microvasculature in European and African-Caribbean people with diabetes. Clin Sci (Lond), 117(6), 229-236. Abstract. Author URL.
Gates PE, Strain WD, Shore AC (2009). Human endothelial function and microvascular ageing. Exp Physiol, 94(3), 311-316. Abstract. Author URL.
Zhang F, Barker AJ, Gates PE, Strain WD, Fulford J, Mazzaro L, Shore AC, Bellenger NG, Lanning C, Shandas R, et al (2009). Noninvasive wall shear stress measurements in human carotid artery using echo particle image velocimetry: Initial clinical studies. Proceedings - IEEE Ultrasonics Symposium, 562-565. Abstract.
Todd DM, Strain WD (2007). Ethnic differences in infants and maternal outcomes in gestational diabetes. DIABETIC MEDICINE, 24, 19-19. Author URL.
Strain WD, Chaturvedi N, Dockery F, Shiff R, Shore AC, Bulpitt CJ, Rajkumar C (2006). Increased arterial stiffness in Europeans and African Caribbeans with type 2 diabetes cannot be accounted for by conventional cardiovascular risk factors. Am J Hypertens, 19(9), 889-896. Abstract. Author URL.
AShore, Bulpitt C, Chaturvedi N, Strain W (2005). Albumin excretion rate and cardiovascular risk: could the association be explained by early microvascular dysfunction. Diabetes, 54(6), 1816-1822.
Strain WD, Chaturvedi N, Bulpitt CJ, Rajkumar C, Shore AC (2005). Albumin excretion rate and cardiovascular risk: could the association be explained by early microvascular dysfunction?. Diabetes, 54(6), 1816-1822. Abstract. Author URL.
Strain WD, Chaturvedi N, Nihoyannopoulos P, Bulpitt CJ, Rajkumar C, Shore AC (2005). Differences in the association between type 2 diabetes and impaired microvascular function among Europeans and African Caribbeans. Diabetologia, 48(11), 2269-2277. Abstract. Author URL.
Strain WD, Chaturvedi N, Shore A, Cruickshank JK, Heagerty AM (2005). Ethnic differences in microvascular structure and function [3] (multiple letters). Journal of Hypertension, 23(7), 1434-1436.
Strain WD, Chaturvedi N, Shore A (2005). Ethnic differences in microvascular structure and function. J Hypertens, 23(7), 1434-1435. Author URL.
Strain WD, Chaturvedi N, Leggetter S, Nihoyannopoulos P, Rajkumar C, Bulpitt CJ, Shore AC (2005). Ethnic differences in skin microvascular function and their relation to cardiac target-organ damage. J Hypertens, 23(1), 133-140. Abstract. Author URL.
Strain D, Bulpitt C, Chaturvedi N, Leggetter S (2004). Ethnic differences in vascular stiffness and relations to hypertensive target organ damage. Journal of Hypertension, 22(9), 1731-1737.
Chaturvedi N, Rajkumar C, Strain WD, Nihoyannopoulos P, Shore AC, Bulpitt CJ (2004). P-440: Ethnic differences in central and augmentation index; do they account for differing susceptibility to left ventricular hypertrophy. American Journal of Hypertension, 17(S1), 195a-195a.
Strain WD (2004). The use of recombinant human B-type natriuretic peptide (nesiritide) in the management of acute decompensated heart failure. Int J Clin Pract, 58(11), 1081-1087. Abstract. Author URL.
Strain W (2004). Who are we hurting? the hesitation by people of color. Positively aware : the monthly journal of the Test Positive Aware Network, 15(4), 23-24.
Strain WD, Lye M (2002). Chronic pain, bereavement and overdose in a depressed elderly woman. Age Ageing, 31(3), 218-219. Author URL.
Strain WD, Chaturvedi N (2002). The renin-angiotensin-aldosterone system and the eye in diabetes. J Renin Angiotensin Aldosterone Syst, 3(4), 243-246. Abstract. Author URL.
Gill G, Swift AC, Jones A, Strain D, Weston PJ (2001). Severe adrenal suppression by steroid nasal drops. J R Soc Med, 94, 350-351.
Chapters
Strain D (2018). Personalised care and research. In (Ed) The Art and Science of Personalising Care with Older People with Diabetes, 175-186.
Conferences
Zirk-Sadowski J, Masoli JAH, delgado J, Strain W, Hamilton W, Henley W, Melzer D, Ble A (In Press). Risks of Longer Term Proton Pump Inhibitor Exposure in 228,752 Older Adults. International Congress of the European Union Geriatric Society. Abstract.
Thompson JY, Nnate DA, Mussad M, Carroll S, Buck P, Strain WD, Banerjee A, Van de Velde N (2022). A SYSTEMATIC REVIEW OF THE IMPACT OF VACCINATION ON LONG COVID. Author URL.
Jordan AN, Aizawa K, Gooding KM, Llewellyn D, Casanova F, Mawson DM, Gates PE, Adingupu DD, Elyas S, Hope SV, et al (2022). ARTERIAL HAEMODYNAMIC PARAMETERS LINKED TO ARTERIAL PULSATILITY, EXCESS WAVE PROPAGATION AND COGNITIVE FUNCTION. Author URL.
Jordan AN, Aizawa K, Gooding KM, Llewellyn D, Casanova F, Mawson DM, Gates PE, Adingupu DD, Elyas S, Hope SV, et al (2022). ARTERIAL HAEMODYNAMIC PARAMETERS LINKED TO ARTERIAL PULSATILITY, EXCESS WAVE PROPAGATION AND COGNITIVE FUNCTION. Author URL.
Jordan AN, Aizawa K, Gooding KM, Llewellyn D, Casanova F, Mawson DM, Gates PE, Adingupu DD, Elyas S, Hope S, et al (2022). Arterial haemodynamic parameters linked to arterial pulsatility, excess wave propagation and cognitive function. European Society of Hypertension. 17th - 20th Jun 2022. Abstract.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Khan F, Colhoun HM, Palombo C, et al (2021). ELEVATED EXCESS PRESSURE INTEGRAL IS ASSOCIATED WITH VASCULAR BIOMARKERS OF SUBCLINICAL ATHEROSCLEROSIS IN OLDER ADULTS. Author URL.
Williams J, Gilchrist M, Fraser D, Strain D, Shore A (2020). CUTANEOUS MICROCIRCULATORY DYSFUNCTION IN PERITONEAL DIALYSIS PATIENTS. Author URL.
Strain WD, Holst AG, Rasmussen S, Saevereid HA, James MA (2020). Effects of liraglutide and semaglutide on stroke subtypes in patients with type 2 diabetes: a post hoc analysis of the LEADER, SUSTAIN 6 and PIONEER 6 trials. Author URL.
Strain WD, Holst AG, Rasmussen S, Saevereid HA, James MA (2020). Effects of liraglutide and semaglutide on stroke subtypes in patients with type 2 diabetes: a post hoc analysis of the LEADER, SUSTAIN 6 and PIONEER 6 trials. Author URL.
Meertens R, Knapp K, Casanova F, Ball S, Strain W (2020). Near infrared spectroscopy for the investigation of vascular haemodynamics in human bone in vivo. Bone Research Society Annual Meeting. 6th - 8th Jul 2020.
Meertens R, Knapp K, Casanova F, Ball S, Fulford J, Merson S, Strain W (2020). Sex-based differences in vascular haemodynamics at the proximal tibia. European Congress of Radiology. 15th - 19th Jul 2020.
Khumalo J, Abdulle M, Almurairi A, Kazimi A, Asiri M, Fulford J, Strain WD, Knapp KM (2020). Short-term intra- and inter-operator precision errors of radiofrequency echographic multispectrometry bone density measurements at the lumbar spine using the Echolight scanner. United Kingdom Imaging and Oncology. 1st - 31st Jul 2020. Abstract.
Foreshaw G, Hauser L, Mucha A, Thompson B, Syan G, Rao S, English P, Strain WD (2020). The benefit of GP-based practice pharmacists in tackling clinical inertia in people with type 2 diabetes. Author URL.
Meertens R, Knapp K, Casanova F, Ball S, Fulford J, Merson S, Strain W (2020). Vascular measurements of the proximal tibia and their associations with bone mineral density. European Congress of Radiology. 15th - 19th Jul 2020.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Khan F, Colhoun HM, Palombo C, et al (2019). ALTERED CENTRAL HAEMODYNAMIC PARAMETERS DERIVED FROM RESERVOIR PRESSURE ANALYSIS: ASSOCIATION WITH BIOMARKERS OF TARGET ORGAN DAMAGE IN OLDER ADULTS. Author URL.
Meertens RM, Knapp KM, Casanova F, Ball SE, Strain WD (2019). Exploring the potential relationships between microvascular haemodynamics and density in bone: a feasibility study utilising near infrared spectroscopy. UKIO 2019. 10th - 12th Jun 2019.
Maskery M, Emsley H, Holscher C, Jones S, Watkins C, Price CI, Strain WD, Werring D (2019). Glucagon like peptide-1 receptor agonists as neuroprotective agents for stroke: a systematic review of pre-clinical studies. Author URL.
Strain WD, McEwan P, Howitt H, Meadowcroft SB (2018). Evaluating clinical outcomes of changing type 2 diabetes patients from other DPP-4 inhibitor therapy to alogliptin in a primary care setting. Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Strain WD, Gates PE, Ostling G, Nilsson J, Khan F, Colhoun HM, et al (2018). PARAMETERS DERIVED FROM RESERVOIR PRESSURE ANALYSIS INDEPENDENTLY PREDICT CARDIOVASCULAR EVENTS IN a MULTI-CENTRE STUDY OF INDIVIDUALS WITH TYPE 2 DIABETES. Author URL.
Masoli JAH, Zirk-Sadowski J, Strain WD, Hamilton W, Delgado J, Henley W, Melzer D, Ble A (2018). QUESTIONING THE SAFETY OF WIDESPREAD PPI PRESCRIBING IN OLDER ADULTS. Author URL.
Casanova F, Adingupu DD, Gooding KM, Aizawa K, Gates PE, Elyas S, Shore AC, Strain DW (2017). Association Between Renal Function and Matrix Metalloproteinases in Type 2 Diabetes. Author URL.
Lim WF, Chivers N, Connolly A, Strain WD (2017). CLINICAL EFFECTIVENESS OF CORTRAK (ENTERAL ACCESS SYSTEM) AT ROYAL DEVON AND EXETER. Author URL.
Strain WD (2017). Cost effectiveness of insulin sparing treatment regimens early in Type 2 diabetes: real world data using a clinical practice database. Author URL.
Jones LC, Attwood D, Strain WD (2017). DOES PREVENTATIVE OUTPATIENT COMPREHENSIVE GERIATRICS ASSESSMENT REDUCE HOSPITAL ADMISSIONS? a SYSTEMATIC REVIEW. Author URL.
Hope SV, Knight BA, Shields BM, Hill A, Choudhary P, Strain WD, Hattersley AT, McDonald TJ, Jones G (2017). RANDOM NON-FASTING C-PEPTIDE CAN BE USED AS a RISK ASSESSMENT TOOL FOR HYPOGLYCAEMIA IN ELDERLY NSULIN-TREATED PATIENTS WITH TYPE 2 DIABETES. Author URL.
Aizawa K, Casanova F, Mawson DM, Gooding KM, Park CM, Elyas S, Adingupu DD, Strain WD, Parker KH, Gates PE, et al (2017). RESERVOIR-PRESSURE ANALYSIS PREDICTS CARDIOVASCULAR EVENTS IN INDIVIDUALS WITH TYPE 2 DIABETES: a SINGLE-CENTRE STUDY. Author URL.
Meertens RM, Casanova F, Strain WD, Knapp K, Thorn C (2017). The use of near-infrared systems for investigations of microvascular haemodynamics in human in vivo bone tissue: a systematic review. International Society of Oxygen Transfer to Tissue Annual Meeting 2017. 19th - 23rd Aug 2017.
Strain WD (2016). A Real-World Cost-Effectiveness Analysis of an Insulin Sparing Treatment Regimen. Author URL.
Strain WD (2016). Cost effectiveness of insulin sparing treatment regimes in type 2 diabetes: data from a real world clinical database. Author URL.
Hope SV, Knight BA, Shields BM, Strain WD, Hattersley AT, Choudhary P, Jones AG (2016). Low c-peptide is associated with high glycaemic variability and hypoglycaemia in insulin-treated patients with Type 2 diabetes. Author URL.
Meertens R, Knapp K, Strain D, Casanova F (2016). NEAR INFRARED SPECTROSCOPY: a POTENTIAL TOOL FOR ASSESSING HAEMODYNAMIC MARKERS OF THE MICROVASCULAR BLOOD SUPPLY WITHIN BONE TISSUE. Author URL.
Aizawa K, Casanova F, Mawson D, Elyas S, Adingupu DD, Gooding KM, Strain WD, Park CM, Parker KH, Gates PE, et al (2016). RESERVOIR-PRESSURE ANALYSIS IN TYPE 2 DIABETES INDIVIDUALS WITH CARDIOVASCULAR DISEASE. Author URL.
Meertens RM, Knapp KM, Strain WD, Casanova F (2016). The use of near infrared spectroscopy (NIRS) as a diagnostic tool to measure microvascular haemodynamics in bone tissue. National Osteoporosis Society 2016. 7th - 9th Nov 2016.
Al-Rubeyi S, Farah W, Furmully M, Meertens R, Shepherd J, Green D, Strain WD, Knapp KM (2016). Vitamin D deficiency and insufficiency in the radiography population: Are we at risk?. Abstract.
Elyas SP, Adingupu D, Aizawa K, Shore AC, Strain WD, Gates PE (2015). Cerebral haemodynamics are different in patients with and without cerebral white matter hyperintensities. Author URL.
Strain WD, Paldanius PM (2015). Clinical Inertia Affects Younger and Older Adults with T2DM Equally, with or Without CKD. Author URL.
Strain WD, Paldanius PM (2015). Clinical inertia affects younger and older adults with type 2 diabetes mellitus equally, with or without CKD. Author URL.
Hope SV, McDonald TJ, Hill AV, Strain WD, Hattersley AT (2015). Low c-peptide is associated in insulin-treated patients with hypoglycaemia unawareness as well as hypoglycaemia frequency. Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson D, Shore AC, Strain WD, Gates PE (2015). PP.20.26.
Strain WD, Brown JD (2014). B12 Deficiency is Under-Diagnosed and Associated with Increased Pulse Pressure in People with Type 2 Diabetes. Author URL.
Clark C, Casanova F, Gooding K, Pamphilon N, Aizawa K, Mawson D, Adingupu D, Ball C, Worthington F, Elyas S, et al (2014). Inter-arm blood pressure difference and differences in arterial stiffness. Author URL.
Elyas S, Shore AC, James MA, Peters A, Eastwood H, Keenan S, Stewart J, Strain WD (2014). Microalbuminuria could predict critical carotid artery stenosis in patients presenting with TIA and minor strokes. Author URL.
Hope SV, Taylor PJ, Shields BM, Oram RA, Chakera AJ, Strain WD, Hattersley AT (2014). Non-specific symptoms associated with hypoglycaemia in the elderly are common in patients treated with metformin only, as well as those treated with insulin or sulphonylureas. Author URL.
Palmer D, Strain WD, Webb B (2014). TURNING OF THE TIDE: DOES TIDEMARK ADVANCEMENT PERPETUATE OSTEOARTHRITIS. Author URL.
Gooding KM, Shore AC, Mawson D, Ball CI, Pitt A, Aizawa K, Strain WD (2013). A pilot study investigating whether dipeptidyl peptidase-IV inhibition alters vascular function in obese men. Author URL.
Aizawa K, Elyas S, Adingupu DD, Casanova F, Gooding KM, Mawson DM, Shore AC, Strain WD, Gates PE (2013). Carotid artery intima-media echogenicity and aortic stiffness in healthy middle-aged and older humans. Author URL.
Strain WD, Lukashevich V, Kothny W, Hoellinger M-J, Paldanius P (2013). INdividualised Treatment targets for EldeRly patients using Vildagliptin Add-on or Lone therapy (INTERVAL) study. Author URL.
Strain WD, Elyas S, Gooding K, Eastwood H, Keenan S, Stewart J, James MA, Shore AC (2013). Microalbuminuria could improve risk prediction of stroke in patients with TIA and minor stroke: the Prognostic Markers of TIA Evolution (ProMOTE) pilot study. Author URL.
Elyas S, Shore AC, Eastwood H, Keenan S, Stewart J, Strain WD (2013). Microalbuminuria could improve risk prediction of stroke in patients with transient ischaemic attacks and minor strokes. Author URL.
Hope SV, Jones AG, Shepherd M, Shields B, Strain D, McDonald T, Knight BA, Hattersley AT (2013). Urinary C-peptide creatinine ratio to detect absolute insulin deficiency in type 2 diabetes. Author URL.
Majekolagbe D, Strain WD, Gates PE, Elyas S, Thorn C, Shore A (2011). Post occlusive microvascular autoregulatory dysfunction is not associated with endothelium dependent or independent vasodilatation. Author URL.
Gosling OE, Iyengar S, Loader R, Morgan-Hughes G, Strain WD, Roobottom C (2011). RADIATION DOSES TRENDS FROM CARDIAC CT USING a CARDIAC SPECIFIC CONVERSION FACTOR: SYSTEM UNDERSTANDING & AN OPTIMISATION STRATEGY SIGNIFICANTLY REDUCES THE DOSE TO THE PATIENTS IN a CLINICAL SERVICE. Author URL.
Whiteman M, Strain WD, Whatmore JL, Gooding K, Ball C, Mawson D, Tooke JE, Shore AC (2011). Sex differences in the association between plasma levels of the novel vasodilatory gas hydrogen sulfide, adiposity and micro- and macrovascular function in vivo. Author URL.
Zhang F, Gates PE, Barker AJ, Strain WD, Gosling OE, Mazzaro L, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2010). A Novel Ultrasound-Based Vascular Profiling Technique (Echo Particle Image Velocimetry): Clinical Validation in 28 Human Subjects and Associations with Age. Author URL.
Zhang F, Gates PE, Strain WD, Gosling OE, Mazzaro L, Barker AJ, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2009). A Novel Ultrasound-based Wall Shear Stress Biomarker (Echo Particle Image Velocimetry) to Generate Hemodynamic Vascular Profiles in Carotid Arteries: Clinical Studies on 16 Healthy Subjects. Author URL.
Strain WD, Chaturvedi NC, Rajkumar C, Bulpitt CJ, Nihoyannopoulos P, Hughes AD, Shore AC (2009). Are Ethnic Differences in Left Ventricular Concentric Remodelling in Those with Diabetes Due to Differences in Microvascular Function?. Author URL.
Strain WD, Shore AC, Melzer D (2009). DOES ALBUMIN CREATININE RATIO ADD PROGNOSTIC INFORMATION AFTER a STROKE? DATA FROM NHANES III. Author URL.
Strain WD, Shore AC, Melzer D (2009). Does Albumin Creatinine Ratio Add Prognostic Information After a Stroke? Data from NHANES III. Author URL.
Gates PE, Zhang F, Strain WD, Gosling OE, Mazzaro L, Barker AJ, Fulford J, Shore AC, Bellenger NG, Lanning C, et al (2009). ECHO PARTICLE IMAGE VELOCIMETRY (ECHO PIV): a NOVEL ULTRASOUND-BASED METHOD FOR THE IN VIVO MEASUREMENT OF WALL SHEAR STRESS IN HUMAN CAROTID ARTERIES. Author URL.
Zhang F, Barker AJ, Gates PE, Strain WD, Fulford J, Mazzaro L, Shore AC, Bellenger NG, Lanning C, Shandas R, et al (2009). In vivo validation of echo particle image velocimetry (Echo PIV) in human carotid arteries using phase-contrast MRI.
Strain WD, Chaturvedi NC, Rajkumar C, Bulpitt CJ, Nihoyannopoulos P, Hughes AD, Shore AC (2009). MICROVASCULAR DYSFUNCTION IS ASSOCIATED WITH CONCENTRIC REMODELLING AND LEFT ATRIAL SIZE INDEPENDENT OF BLOOD PRESSURE AND CARDIOVASCULAR RISK FACTORS. Author URL.
Strain WD, Gilbert KL, Macleod KM, Fulford J, Shore AC, Stokes KA (2009). The effects of suppression of endogenous insulin on hepatic and quadriceps glycogen stores after 60 min of submaximal exercise in healthy adult males. Author URL.
Strain WD, Harman K, Leitch S, Forsythe E (2008). Albumin:creatinine ratio at presentation predicts mortality and functional outcomes after stroke. Author URL.
Strain WD, Chaturvedi N, Rajkumar C, Bulpitt C, Shore AC (2006). Microvascular functional abnormalities are associated left ventricular hypertrophy. Author URL.
Chaturvedi N, Rajkumar C, Strain WD, Nihoyannopoulos P, Shore AC, Bulpitt CJ (2004). Ethnic differences in central and augmentation index; Do they account for differing susceptibility to left ventricular hypertrophy. Author URL.
Chaturvedi N, Bulpitt CJ, Leggetter S, Schiff R, Nihoyannopoulos P, Strain WD, Shore AC, Rajkumar C (2004). Ethnic differences in vascular stiffness and relations to hypertensive target organ damage. Abstract. Author URL.
Debney MT, Hughes AD, Thom SAM, Strain WD, Chaturvedi N (2004). Explanations for the elevated stroke risk in south Asians. Author URL.
Strain WD, Chaturvedi N, Shore AC, Bulpitt CJ, Rajkumar C (2004). Pulse wave velocity is worse, but systemic arterial compliance is better in African Caribbeans compared to Europeans; the breaking of "natural confounders". Author URL.
Strain WD, Chaturvedi N, Shore AC, Bulpitt CJ, Rajkumar C (2004). The effects of diabetes on arterial stiffness in a bi-ethnic populations. Author URL.
Strain WD, Chaturvedi NC, Rajkumar C, Nihoyannopoulos P, Bulpitt CJ, Shore AC (2003). Ethnic differences in microvasculature in diabetes: a possible explanation for the greater vulnerability of people of Black African descent to vascular target organ damage. Author URL.
Strain WD, Chaturvedi N, Rajkumar C, Bulpitt CJ, Nihoyannopoulos P, Shore AC (2003). Ethnic differences in microvasculature: a possible explanation for the greater vulnerability of people of Black African descent to hypertensive target organ damage. Author URL.
External Engagement and Impact
Committee/panel activities
Chair of the British Medical Association Medical Academic Staff Committee
Chair of BMA Board of Science
Medical Advisor to Action for ME
Member of BMA Council
Editorial responsibilities
Associate Editor to Diabetes Medicine responsible for older adults
