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Dr Craig Beall

Dr Craig Beall

Research Fellow

+44 (0)1392 408209

RILD Building 4.06

Follow on Twitter @Craig_Beall

Techniques
Electrophysiology
Western blotting
Fixed and live-cell imaging
Enzyme/kinase assays
Calcium imaging
Biosensing (Sarissa probes)

Upcoming Talks
14th October 2017: Sidmouth Science Festival: "How our brains love sugar; in health and disease"

Invited talks/seminars/media engagement
• Oct 2016: Diabetes UK Exeter group
• Oct 2016: JDRF Discovery Day; Eden Project
• Sept 2016: Diabetes UK Torbay group
• May 2016: Diabetes UK Gifts in Wills; Royal Albert Memorial Museum
• Nov 2015: BBC Radio Devon; Hypoglycaemia awareness week radio interview
• July 2015: Diabetes UK Legacies: Plymouth Aquarium
• Mar 2015: Diabetes UK South West Volunteering conference
• May 2015: Pint of Science Exeter; Beautiful minds team leader and presenter
• Oct 2014: JDRF Patrons event; Armorers Hall, London

Honours and Awards

• 2016: University of Exeter Above and Beyond Award for Collaboration
• 2012: College of Medicine Staff Poster Prize (1st prize)
• 2011: College of Medicine Staff Poster Prize (1st prize)
• 2003: Awarded Carl Zeiss Prize for Best Laboratory-Based Honours Project and short-listed for the UK-wide Science, Engineering and Technology Student of the Year Award
• 2000: Awarded Schering Group award for Academic Excellence and Dedication to Course (Fife College)

Professional Memberships

• Physiological society (2003-)
• Diabetes UK (2011-)
• Society for Endocrinology (2011-)
• British Society for Neuroendocrinology (2011-)
• British Pharmacological Society (2014-)

Qualifications

  • PhD
  • BSc(Hons) First Class

Career

Dr Craig Beall completed his degree in Pharmacology (BSc Hons; University of Dundee) in 2003 before obtaining a Wellcome Trust Prize Studentship to undertake doctoral studies in the laboratory of Prof Mike Ashford, University of Dundee. Doctoral studies focused on mechanisms of glucose sensing in pancreatic beta cells and hypothalamic neurons, with a particular focus on AMP-activated protein kinase and ATP-sensitive K+ channels.

Following a year in at the University of Liverpool investigating the role of K+ channels in skeletal muscle insulin sensitivity, Dr Beall moved back to the University of Dundee to work with Professors Rory McCrimmon and Prof Ashford to focus on mechanisms of hypoglycaemia detection. Dr Beall was a recipient of a Juvenile Diabetes Research Foundation postdoctoral fellowship (2010-2013) to develop and establish an in vitro model for investigating the mechanisms of hypothalamic glucose sensing.

Links

Research

Research interests

The Beall laboratory is interested in the complex adaptive responses to acute and recurrent hypoglycaemia, which is still a frequent concern for people with type 1 and advanced (insulin-treated) type 2 diabetes. The lab focuses on deciphering the neuronal and glial responses to hypoglycaemia and the communication between both cell types. 

Working with Dr Kate Ellacott, we are also interested in astrocyte-neuron communication during energy excess, such as a high fat diet and whether astrocytes play in a role in regulating feeding behaviour.

In collaboration with Prof Andrew Randall and Dr Ritchie Williamson, we are investigating how glucose variation alters signalling processes in human neural cells and how this relates to dementia risk.

In collaboration with Dr Benjamin Wall, we are examining the pathways that are altered in muscle by glucose/lipid variation and how this may relate to aging and diabetes-induced anabolic resistance (the inability to make enough muscle protein to maintain strength and function).

Current Staff (as DoS/line manager):
Julia Vlachaki-Walker, P/T MPhil student/research technician (Diabetes UK)
Paul Weightman Potter, PhD student (Mary Kinross Charitable Trust)
Ana Miguel Cruz, PhD student (UEMS/CLES)
Dr Yasaman Malekizadeh, postdoctoral research associate (JDRF)
Aimes Somes (U/G laboratory-based project student; 2016-17)
 

Second/Co-supervisor:
Lisa Logie (PhD student; University of Dundee)
Dr Lydia Hanna (postdoctoral researcher)
Dr Nadia Hammad (research technician)
Josephine Robb (Masters student)
Alastair MacDonald (PhD student)
Nicole Morrissey (PhD student)
Benjamin Hall (PhD student)

Alumni:
Jade Shoulder, associate researcher
Dr Ashley Nicholls (research assistant. Currently a postdoc at the University of Cambridge)
Amrinder Malhi (British Society for Neuroendocrinology funded summer studentship; 2015; currently an intern at the International Diabetes Federation, London)
Dr Amy Cameron (visiting postdoctoral research fellow; Society for Endocrinology; 2015-16)
Jennie Gabriel (Society for Endocrinology funded summer student; 2014, currently studying for a PhD studying dementia at the University of Dundee).

Research projects

  • Does an orally active brain permeable AMPK activator amplify the counterregulatory response to hypoglycaemia in a model of type 1 diabetes; JDRF Innovative Grant (2017-2018)
  • The role of astroytes in the homeostatic control of food intake; MRC project grant (2016-2019)
  • Does acute and recurrent insulin-induced hypoglycaemia alter DNA methylation in human neural cells? Novo Nordisk Research Foundation UK; (2016-2017)
  • Defining the role of hypothalamic astroglia in the regulation of the homeostatic control of food intake; GW4 MRC doctoral training partnership (2016-2019)
  • Targeting the hypothalamic purinergic system for the regulation of whole body energy homeostasis; Diabetes UK (2013-2018)
  • Impact of diabetes glucose variability on neural signalling in human brain cells - relationship to dementia risk; Mary Kinross Charitable Trust PhD studentship; collaboration with Prof A Randall, Exeter (2015-2018)
  • Mechanisms of muscle anabolic resistance in diabetes and ageing; UEMS PhD studentship; collaboration with Dr B Wall, Exeter (2016-2019)

Grants/Funding

  • Mary Kinross Charitable Trust PhD Studentship (2015-2018; £85,500)
  • British Society for Neuroendocrinology Summer Studentship (Amrinder Malhi; summer 2015; £1,120)
  • Diabetes UK RD Lawrence Fellowship (2013-2018; £436,584)
  • Society for Endocrinology Early Career Grant (2014-2015; £9,720)
  • Society for Endocrinology Summer Studentship (Jennie Gabriel; summer 2014; £2,850)
  • Anonymous Trust (PI; Co-I: Professors Ashford & McCrimmon, University of Dundee, 2014-2015; £10,000)
  • British Society for Neuroendocrinology (PI; 2013-2014; £4,970)
  • Tenovus Scotland (PI; Co-I: Professors Ashford & Mccrimmon, 013-2014; £12,000)
  • Anonymous Trust (2012-2013; £10,000)
  • Juvenile Diabetes Research Foundation Postdoctoral Fellowship (2010-2013; $154,000)

Research networks

Collaborations:

Dr Kate Ellacott (University of Exeter; neural mechanisms of energy sensing)
Professor Andy Randall (University of Exeter; glucose variability and dementia risk; neuronal Katp channels)
Dr Ritchie Williamson (University of Bradford; glucose variability and dementia risk)
Prof Tony Pickering (University of Bristol; neural mechanisms of energy sensing)
Dr Graham Rena (University of Dundee; regulation of hepatic physiology by metformin)
Dr Benjamin Wall (University of Exeter; muscle anabolic resistance)
Drs Emma Dempster and Aaron Jeffries (University of Exeter; regulation of DNA methylation by glucose variation)
Professor Rory McCrimmon (University of Dundee; neural mechanisms of energy sensing)
Professor Mike Ashford (University of Dundee; neural mechanisms of energy sensing)

Anyone interested in working in the Beall laboratory, either undergraduate, postgraduate or postdoctoral, please get in touch with Dr Beall.

Research grants

  • 2016 Medical Research Council
    Title: The role of hypothalamic astrocytes in the homeostatic regulation of feeding behaviour
  • 2016 Medical Research Council
    GW4 MRC Doctoral Training Partnership PhD Studentship Title: Defining the contribution of hypothalamic astroglia to the homeostatic regulation of food intake
  • 2016 Juvenile Diabetes Research Foundation
    Title: Does an orally active, brain permeable AMPK activator improve hypoglycemia counterregulation in type 1 diabetes?

Links


Key publications | Publications by category | Publications by year

Key publications


Vlachaki Walker JM, Robb JL, Cruz AM, Malhi A, Weightman Potter PG, Ashford ML, McCrimmon RJ, Ellacott KL, Beall C (In Press). AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner. Diabetes, Obesity and Metabolism
Dadak S, Beall C, Vlachaki Walker JM, Soutar MPM, McCrimmon RJ, Ashford MLJ (2017). Oleate induces KATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge. Neuroscience, 346, 29-42. Abstract.  Author URL.  Full text.
Walker JMV, Malhi A, Hardy H, Chilton J, Beall C (2016). A769662 regulates intracellular calcium and extracellular ATP independent of AMPK. DIABETIC MEDICINE, 33, 50-50. Author URL.
Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJK, Savinko T, Wong AKF, et al (2016). Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res, 119(5), 652-665. Abstract.  Author URL.  Full text.
Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, et al (2016). Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metab, 23(5), 821-836. Abstract.  Author URL.  Full text.
Haythorne E, Hamilton DL, Findlay JA, Beall C, McCrimmon RJ, Ashford MLJ (2016). Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons. Neuropharmacology, 111, 212-222. Abstract.  Author URL.  Full text.

Publications by category


Journal articles

Vlachaki Walker JM, Robb JL, Cruz AM, Malhi A, Weightman Potter PG, Ashford ML, McCrimmon RJ, Ellacott KL, Beall C (In Press). AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner. Diabetes, Obesity and Metabolism
Dadak S, Beall C, Vlachaki Walker JM, Soutar MPM, McCrimmon RJ, Ashford MLJ (2017). Oleate induces KATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge. Neuroscience, 346, 29-42. Abstract.  Author URL.  Full text.
Walker JMV, Malhi A, Hardy H, Chilton J, Beall C (2016). A769662 regulates intracellular calcium and extracellular ATP independent of AMPK. DIABETIC MEDICINE, 33, 50-50. Author URL.
Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJK, Savinko T, Wong AKF, et al (2016). Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res, 119(5), 652-665. Abstract.  Author URL.  Full text.
Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, et al (2016). Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metab, 23(5), 821-836. Abstract.  Author URL.  Full text.
Haythorne E, Hamilton DL, Findlay JA, Beall C, McCrimmon RJ, Ashford MLJ (2016). Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons. Neuropharmacology, 111, 212-222. Abstract.  Author URL.  Full text.
Walker JV, Ashford MLJ, McCrimmon RJ, Beall C (2016). Exposure of astrocytes to recurrent low glucose delays AMPK phosphorylation and alters ATP and lactate release. DIABETIC MEDICINE, 33, 54-54. Author URL.
Beall C, Walker JMV, Ashford MLJ, McCrimmon RJ (2015). A critical role for AMP-activated protein kinase in regulation of gliotransmitter release from astrocytes. DIABETIC MEDICINE, 32, 62-62. Author URL.
Cameron AR, Morrison V, McNeilly AD, Forteath C, Beall C, Stewart CA, Balfour DJK, Sutherland CD, Sakamoto K, Fagerholm SC, et al (2015). Anti-inflammatory effects of metformin. DIABETIC MEDICINE, 32, 54-55. Author URL.
Cameron A, Forteath C, Beall C, Rena G (2015). Anti-inflammatory effects of metformin and their relationship to the therapeutic action of the drug. Endocrine Abstracts
Walker JV, Ashford M, McCrimmon R, Beall C (2015). Characterisation of the astrocytic response to acute and recurrent hypoglycaemia. Endocrine Abstracts
Walker JMV, Gabriel J, Ashford MLJ, McCrimmon RJ, Beall C (2015). Modulation of astrocytic lactate release during hypoglycaemia by AMP-activated protein kinase and noradrenaline. DIABETIC MEDICINE, 32, 62-63. Author URL.
Hamilton DL, Beall C, Jeromson S, Chevtzoff C, Cuthbertson DJ, Ashford MLJ (2014). Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle. J Physiol Sci, 64(1), 13-20. Abstract.  Author URL.
Beall C, Watterson KR, McCrimmon RJ, Ashford MLJ (2013). AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels. J Bioenerg Biomembr, 45(3), 229-241. Abstract.  Author URL.
Beall C, Haythorne E, Fan X, Du Q, Jovanovic S, Sherwin RS, Ashford MLJ, McCrimmon RJ (2013). Continuous hypothalamic K(ATP) activation blunts glucose counter-regulation in vivo in rats and suppresses K(ATP) conductance in vitro. Diabetologia, 56(9), 2088-2092. Abstract.  Author URL.
Ashford M, Beall C, McCrimmon R (2012). Hypoglycaemia: exercise for the brain?. J Neuroendocrinol, 24(10), 1365-1366. Abstract.  Author URL.
Beall C, Hamilton DL, Gallagher J, Logie L, Wright K, Soutar MP, Dadak S, Ashford FB, Haythorne E, Du Q, et al (2012). Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. Diabetologia, 55(9), 2432-2444. Abstract.  Author URL.  Full text.
Beall C, Ashford ML, McCrimmon RJ (2012). The physiology and pathophysiology of the neural control of the counterregulatory response. Am J Physiol Regul Integr Comp Physiol, 302(2), R215-R223. Abstract.  Author URL.
Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford MLJ (2010). Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J, 429(2), 323-333. Abstract.  Author URL.  Full text.

Conferences

Piipari K, Beall C, Al-Qassab H, Smith MA, Carling D, Viollet B, Ashford MLJ, Withers DJ (2010). Key Role of AMP-Activated Protein Kinase in Pancreatic Beta Cell Glucose-Sensing and Whole Body Glucose Homeostasis.  Author URL.

Publications by year


In Press

Vlachaki Walker JM, Robb JL, Cruz AM, Malhi A, Weightman Potter PG, Ashford ML, McCrimmon RJ, Ellacott KL, Beall C (In Press). AMP-activated protein kinase activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner. Diabetes, Obesity and Metabolism

2017

Dadak S, Beall C, Vlachaki Walker JM, Soutar MPM, McCrimmon RJ, Ashford MLJ (2017). Oleate induces KATP channel-dependent hyperpolarization in mouse hypothalamic glucose-excited neurons without altering cellular energy charge. Neuroscience, 346, 29-42. Abstract.  Author URL.  Full text.

2016

Walker JMV, Malhi A, Hardy H, Chilton J, Beall C (2016). A769662 regulates intracellular calcium and extracellular ATP independent of AMPK. DIABETIC MEDICINE, 33, 50-50. Author URL.
Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJK, Savinko T, Wong AKF, et al (2016). Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status. Circ Res, 119(5), 652-665. Abstract.  Author URL.  Full text.
Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martínez de Morentin PB, et al (2016). Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Cell Metab, 23(5), 821-836. Abstract.  Author URL.  Full text.
Haythorne E, Hamilton DL, Findlay JA, Beall C, McCrimmon RJ, Ashford MLJ (2016). Chronic exposure to KATP channel openers results in attenuated glucose sensing in hypothalamic GT1-7 neurons. Neuropharmacology, 111, 212-222. Abstract.  Author URL.  Full text.
Walker JV, Ashford MLJ, McCrimmon RJ, Beall C (2016). Exposure of astrocytes to recurrent low glucose delays AMPK phosphorylation and alters ATP and lactate release. DIABETIC MEDICINE, 33, 54-54. Author URL.

2015

Beall C, Walker JMV, Ashford MLJ, McCrimmon RJ (2015). A critical role for AMP-activated protein kinase in regulation of gliotransmitter release from astrocytes. DIABETIC MEDICINE, 32, 62-62. Author URL.
Cameron AR, Morrison V, McNeilly AD, Forteath C, Beall C, Stewart CA, Balfour DJK, Sutherland CD, Sakamoto K, Fagerholm SC, et al (2015). Anti-inflammatory effects of metformin. DIABETIC MEDICINE, 32, 54-55. Author URL.
Cameron A, Forteath C, Beall C, Rena G (2015). Anti-inflammatory effects of metformin and their relationship to the therapeutic action of the drug. Endocrine Abstracts
Walker JV, Ashford M, McCrimmon R, Beall C (2015). Characterisation of the astrocytic response to acute and recurrent hypoglycaemia. Endocrine Abstracts
Walker JMV, Gabriel J, Ashford MLJ, McCrimmon RJ, Beall C (2015). Modulation of astrocytic lactate release during hypoglycaemia by AMP-activated protein kinase and noradrenaline. DIABETIC MEDICINE, 32, 62-63. Author URL.

2014

Hamilton DL, Beall C, Jeromson S, Chevtzoff C, Cuthbertson DJ, Ashford MLJ (2014). Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle. J Physiol Sci, 64(1), 13-20. Abstract.  Author URL.

2013

Beall C, Watterson KR, McCrimmon RJ, Ashford MLJ (2013). AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channels. J Bioenerg Biomembr, 45(3), 229-241. Abstract.  Author URL.
Beall C, Haythorne E, Fan X, Du Q, Jovanovic S, Sherwin RS, Ashford MLJ, McCrimmon RJ (2013). Continuous hypothalamic K(ATP) activation blunts glucose counter-regulation in vivo in rats and suppresses K(ATP) conductance in vitro. Diabetologia, 56(9), 2088-2092. Abstract.  Author URL.

2012

Ashford M, Beall C, McCrimmon R (2012). Hypoglycaemia: exercise for the brain?. J Neuroendocrinol, 24(10), 1365-1366. Abstract.  Author URL.
Beall C, Hamilton DL, Gallagher J, Logie L, Wright K, Soutar MP, Dadak S, Ashford FB, Haythorne E, Du Q, et al (2012). Mouse hypothalamic GT1-7 cells demonstrate AMPK-dependent intrinsic glucose-sensing behaviour. Diabetologia, 55(9), 2432-2444. Abstract.  Author URL.  Full text.
Beall C, Ashford ML, McCrimmon RJ (2012). The physiology and pathophysiology of the neural control of the counterregulatory response. Am J Physiol Regul Integr Comp Physiol, 302(2), R215-R223. Abstract.  Author URL.

2010

Piipari K, Beall C, Al-Qassab H, Smith MA, Carling D, Viollet B, Ashford MLJ, Withers DJ (2010). Key Role of AMP-Activated Protein Kinase in Pancreatic Beta Cell Glucose-Sensing and Whole Body Glucose Homeostasis.  Author URL.
Beall C, Piipari K, Al-Qassab H, Smith MA, Parker N, Carling D, Viollet B, Withers DJ, Ashford MLJ (2010). Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia. Biochem J, 429(2), 323-333. Abstract.  Author URL.  Full text.

Administrative responsibilities

Academic lead for the UEMS Postgraduate Journal Club (2016 - present)

Academic lead for Summer Vacation Scholarship Competition (2017-present)


Committee/panel activities

January 2017- present: Diabetes UK Clinical Studies Group (CSG5): Long term self-management & glycaemic control

2017-2018 University of Exeter Medical School Senate Representative (elected)


International recognition, such as international research collaborations, visiting research posts in overseas institutions, involvement at senior levels in international research associations, acting as referee for national and international research councils.

March 2017: JDRF Strategies to Prevent and Treat Hypoglycemia Unawareness Workshop; New York.


Workshops organised

January 2017: Agilent Seahorse users workshop - Univeristy of Exeter

BMBS Year 2: LSRC Excitotoxicity, neurotoxicity and neurodegeneration in Parkinsons Disease and related diseases

BMBS Year 1: Problem-based learning facilitator (BMBS)

Medical Sciences Year 2: Foundations in Neuroscience - Journal club/science communications facilitator

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