Overview
Clare is the Director of Education and Student Experience for undergraduate Biomedical Sciences programmes and joined the Medical School in November 2011. She is involved in teaching on the Medicine, Neuroscience, Sport and Exercise Medical Sciences and Medical Sciences degree programmes.
Qualifications
2001 BSc(Hons) Medical Biochemistry, University of Birmingham
2005 PhD Biochemistry, University of Birmingham
2013 PCAP - Postgraduate Certificate in Academic Practice, University of Exeter
2014 FHEA - Fellow of the Higher Education Academy
2024 SFHEA - Advance HE Senior Fellow
MRSB Member of the Royal Society of Biology
Career
Before joining the Medical School in Novermber 2011, Clare was involved in cardiovascular science research, with a particular focus on the molecular mechanisms of cardiac muscle contractile regulation. After undertaking her undergraduate dissertation project and PhD in this field, she was a postdoctoral researcher in cardiovascular research laboratories in the College of Veterinary Medicine, Washington State University, Pullman, USA (2004-2006), the National Heart and Lung Insitute, Imperial College London (2006-2008), the Research Department of Metabolism and Experimental Therapeutics, University College London (2008-2009) and the MRC Clinical Sciences Centre, Imperial College London (2009-2011).
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Publications
Journal articles
Bayliss CR, Jacques AM, Leung M-C, Ward DG, Redwood CS, Gallon CE, Copeland O, McKenna WJ, Dos Remedios C, Marston SB, et al (2013). Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.
Cardiovasc Res,
97(3), 500-508.
Abstract.
Author URL.
Gollapudi SK, Gallon CE, Chandra M (2013). The tropomyosin binding region of cardiac troponin T modulates crossbridge recruitment dynamics in rat cardiac muscle fibers.
Journal of Molecular Biology,
425(9), 1565-1581.
Abstract.
Dyer EC, Jacques AM, Hoskins AC, Ward DG, Gallon CE, Messer AE, Kaski JP, Burch M, Kentish JC, Marston SB, et al (2009). Functional analysis of a unique troponin c mutation, GLY159ASP, that causes familial dilated cardiomyopathy, studied in explanted heart muscle.
Circ Heart Fail,
2(5), 456-464.
Abstract.
Author URL.
Messer AE, Gallon CE, McKenna WJ, Dos Remedios CG, Marston SB (2009). The use of phosphate-affinity SDS-PAGE to measure the cardiac troponin I phosphorylation site distribution in human heart muscle.
Proteomics Clin Appl,
3(12), 1371-1382.
Abstract.
Author URL.
Gallon CE (2008). Current techniques for the study of troponin I phosphorylation in human heart.
J Muscle Res Cell Motil,
29(6-8), 169-172.
Abstract.
Author URL.
Jacques AM, Copeland O, Messer AE, Gallon CE, King K, McKenna WJ, Tsang VT, Marston SB (2008). Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle.
J Mol Cell Cardiol,
45(2), 209-216.
Abstract.
Author URL.
Jacques AM, Briceno N, Messer AE, Gallon CE, Jalilzadeh S, Garcia E, Kikonda-Kanda G, Goddard J, Harding SE, Watkins H, et al (2008). The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy.
Cardiovasc Res,
79(3), 481-491.
Abstract.
Author URL.
Gallon CE (2008). Troponin C. Alias: Contractile calcium switch.
Calcium Binding Proteins,
3(1).
Abstract.
Gallon CE, Tschirgi ML, Chandra M (2006). Differences in myofilament calcium sensitivity in rat psoas fibers reconstituted with troponin T isoforms containing the alpha- and beta-exons.
Arch Biochem Biophys,
456(2), 127-134.
Abstract.
Author URL.
Patchell VB, Gallon CE, Evans JS, Gao Y, Perry SV, Levine BA (2005). The regulatory effects of tropomyosin and troponin-I on the interaction of myosin loop regions with F-actin.
J Biol Chem,
280(15), 14469-14475.
Abstract.
Author URL.
Ward DG, Brewer SM, Calvert MJ, Gallon CE, Gao Y, Trayer IP (2004). Characterization of the interaction between the N-terminal extension of human cardiac troponin I and troponin C.
BIOCHEMISTRY,
43(13), 4020-4027.
Author URL.
Ward DG, Brewer SM, Calvert MJ, Gallon CE, Gao Y, Trayer IP (2004). Characterization of the interaction between the N-terminal extension of human cardiac troponin I and troponin C.
Biochemistry,
43(13), 4020-4027.
Abstract.
Author URL.
Ward DG, Brewer SM, Gallon CE, Gao Y, Levine BA, Trayer IP (2004). NMR and mutagenesis studies on the phosphorylation region of human cardiac troponin I.
Biochemistry,
43(19), 5772-5781.
Abstract.
Author URL.
Patchell VB, Gallon CE, Hodgkin MA, Fattoum A, Perry SV, Levine BA (2002). The inhibitory region of troponin-I alters the ability of F-actin to interact with different segments of myosin.
Eur J Biochem,
269(20), 5088-5100.
Abstract.
Author URL.
Conferences
Marston SB, Messer AE, Gallon CE, Sancho-Sollis R, Walker JW (2010). DETERMINATION OF TROPONIN I PHOSPHORYLATION SITES IN HUMAN HEART MUSCLE.
Author URL.
Bayliss CR, Messer AE, Copeland O, Gallon CE, Marston SB (2010). THIN FILAMENTS RECONSTITUTED WITH TROPONIN EXTRACTED FROM PATIENTS WITH HYPERTROPHIC OBSTRUCTIVE CARDIOMYOPATHY ARE FUNCTIONALLY ABNORMAL.
Author URL.
Garcia EA, Kanda GK, Lyon A, Gallon CE, Messer AE, O'Gara P, Marston SB, Harding SE (2008). Tonic support of contraction involving the PI3 kinase pathway in ventricular myocytes from failing human heart.
Author URL.
Jacques AM, Messer AE, Gallon CE, Tsang V, McKenna WJ, Marston SB (2007). A comparison between TnT, TnI, MyBP-C and MLC-2 phosphorylation in tissue from septal myectomies of hypertrophic obstructive cardiomyopathy patients and donor hearts.
Author URL.
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Teaching
- Cardiovascular science
- Protein biochemistry
- Case based interdisciplinary Medical Sciences
- Small group problem based learning
- Academic tutoring
Modules
2023/24
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