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Dr Andrew Wood

Dr Andrew Wood

Research Fellow in Statistical Genetics

6330

Medical School Building 

I am statistical geneticist interested in the analysis of population-based studies to investigate the role of genetic variation inolved in aetiology of common diseases and variation on quantiative traits. My phenotypic interests include type 2 diabetes, glycemic traits, anthropometric traits and gene expression levels. In addition I am also interested in the underlying genetic architecture of complex traits and models underlying specific genetic associations.

I apply the latest statistical/computational analysis methods and technologies (inc. whole-genome sequencing) to "Big Data" sets to elucidate the role of genetics for complex traits. I am also interested in the development of computational and statistical methods used in the analysis of genetic and phenotypic data (e.g. metaheuristic-based methods).

Qualifications

2009-2013: PhD - Next Generation Genome-wide Association Studies for Complex Human Quantitative Traits, Peninsula College of Medicine and Dentistry

2006-2007: MRes Bioinformatics, University of Exeter

2003-2006: BSc (hons) Computer Science (2:1)

 

Career

Conference Presentations:

Platform: "Detecting deviation from polygenic modes of inheritance in the extreme
tails of human complex traits", Probabilistic Modeling in Genomics 2016, University of Oxford.

Platform: "Imputation of rare variants from the new Haplotype Reference Consortium identifies associations missed by 1000 Genomes", American Society of Human Genetics, 9th October 2015, Baltimore, USA,

Platform: "Analysis of variants obtained through whole-genome sequencing provides an alternative explanation to apparent epistasis", American Society of Human Genetics, 21st October 2014, San Diego, USA,

Platform: "An alternative explanation to apparent epistasis", The 1000 Genomes Project and Beyond, 25th June 2014, Churchill College, Cambridge, UK,

Platform: "Low-pass whole-genome sequencing in Europeans identifies multiple low frequency-large effect associations", American Society of Human Genetics, 23rd October 2013, Boston, USA

Poster: "Deep whole-genome sequencing in pedigrees to quantify the contribution of private variants to type 2 diabetes and related metabolic traits", Genomics of Common Disease, Keble College, Oxford, 9th September 2013.

Poster: "Low-pass whole-genome sequencing in Europeans identifies multiple low frequency-large effect associations", Genomics of Common Disease, Keble College, Oxford, 8th September 2013.

Poster: "Defining the role of common variation in the genomic and biological architecture of adult human height", Genomics of Common Disease, Keble College, Oxford, 8th September 2013.

Platform: "Deep whole-genome sequencing in pedigrees to quantify the contribution of low frequency, rare and private variants to Type 2 Diabetes and related glycemic traits", EASD-SDDG, 3rd May 2013, Malmo, Sweden.

Poster: "1000 Genomes imputation identifies low frequency-large effect circulating biomarker associations undetected by HapMap based imputation", American Society of Human Genetics, 7th November 2012, San Francisco, USA.

Platform: "Genome-wide association studies (GWAS) for height variations: where are we now?", Symposium, European Society of Paediatric Endocrinology, 22nd September 2012, Leipzig, Germany.

Platform: "1000 Genomes Imputation Identifies Low-Frequency, Large-Effect Biomarker Associations", 1000 Genomes Community Meeting, 13th July 2012, Ann Arbor, Michigan, USA.

Platform: "Deep sequencing to identify variants associated with diabetes and diabetes related traits", European Society of Human Genetics, 23rd June 2012, Nuremberg, Germany.

Platform: "Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association", Lenna Peltonen School of Human Genetics", Tuesday 9th August 2011, Sanger Institute, Hinxton, Cambridge, UK.

Poster: "Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association", Genomics of Common Diseases, August 2011, Sanger Institute, Hinxton, Cambridge, UK.

Platform: "Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association", American Society of Human Genetics, Wednesday 13th October 2011, Montreal, Canada.

Poster: "Common genetic variants associated with fasting glucose in Europeans have similar effects in South Asian individuals from Pakistan", American Society of Human Genetics, Washington D.C., USA.

Platform: "Complete Genomics: the Exeter experience", Complete Genomics Forum, 12th October 2010, San Francisco, USA.

Research

Research interests

I am statistical geneticist interested in the analysis of population-based studies to investigate the role of genetic variation inolved in aetiology of common diseases and variation on quantiative traits. My phenotypic interests include type 2 diabetes, glycemic traits, anthropometric traits and gene expression levels. 

I apply the latest statistical/computational analysis methods and technologies (inc. whole-genome sequencing) to further the understanding. I am also interested in the development of computational and statistical methods used in the analysis of genetic data.

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (In Press). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics Full text.
Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, et al (In Press). The genetic architecture of type 2 diabetes. Nature, 536(7614), 41-47. Abstract.  Author URL.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol Abstract.  Author URL.  Full text.
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, et al (2017). Rare and low-frequency coding variants alter human adult height. Nature, 542(7640), 186-190. Abstract.  Author URL.  Full text.
McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, et al (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet, 48(10), 1279-1283. Abstract.  Author URL.  Full text.
Chen G-B, Lee SH, Robinson MR, Trzaskowski M, Zhu Z-X, Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, et al (2016). Across-cohort QC analyses of GWAS summary statistics from complex traits. Eur J Hum Genet, 25(1), 137-146. Abstract.  Author URL.
Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NMG, et al (2016). Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA, 315(11), 1129-1129. Full text.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.  Full text.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.  Full text.
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.  Full text.
Kilpeläinen TO, Carli JFM, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, et al (2016). Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun, 7 Abstract.  Author URL.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Almeida M, Blondell L, Peralta JM, Kent JW, Jun G, Teslovich TM, Fuchsberger C, Wood AR, Manning AK, Frayling TM, et al (2016). Independent test assessment using the extreme value distribution theory. BMC Proc, 10(Suppl 7), 245-249. Abstract.  Author URL.
Blangero J, Teslovich TM, Sim X, Almeida MA, Jun G, Dyer TD, Johnson M, Peralta JM, Manning A, Wood AR, et al (2016). Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19. BMC Proc, 10(Suppl 7), 71-77. Abstract.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet Abstract.  Author URL.  Full text.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.  Full text.
Yaghootkar H, Stancáková A, Freathy RM, Vangipurapu J, Weedon MN, Xie W, Wood AR, Ferrannini E, Mari A, Ring SM, et al (2015). Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion. Diabetes, 64(6), 2279-2285. Abstract.  Author URL.  Full text.
Pers TH, Karjalainen JM, Chan Y, Westra H-J, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, et al (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun, 6 Abstract.  Author URL.
Westra H-J, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, et al (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet, 11(5). Abstract.  Author URL.
Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, et al (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523(7561), 459-462. Abstract.  Author URL.
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, et al (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47(12), 1415-1425. Abstract.
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, et al (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet, 47(12), 1415-1425. Abstract.  Author URL.
Reppe S, Wang Y, Thompson WK, McEvoy LK, Schork AJ, Zuber V, LeBlanc M, Bettella F, Mills IG, Desikan RS, et al (2015). Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci. PLoS ONE, 10(12). Abstract.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, et al (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206. Abstract.  Author URL.  Full text.
Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Esko T, Wood AR, Yang J, et al (2015). Mendelian randomization study of height and risk of colorectal cancer. Int J Epidemiol, 44(2), 662-672. Abstract.  Author URL.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, et al (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196. Abstract.  Author URL.  Full text.
Robinson MR, Hemani G, Medina-Gomez C, Mezzavilla M, Esko T, Shakhbazov K, Powell JE, Vinkhuyzen A, Berndt SI, Gustafsson S, et al (2015). Population genetic differentiation of height and body mass index across Europe. Nature Genetics, 47(11), 1357-1361. Abstract.
Robinson MR, Hemani G, Medina-Gomez C, Mezzavilla M, Esko T, Shakhbazov K, Powell JE, Vinkhuyzen A, Berndt SI, Gustafsson S, et al (2015). Population genetic differentiation of height and body mass index across Europe. Nature Genetics Abstract.
Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW (2015). Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes, 64(4), 1484-1491. Abstract.  Author URL.  Full text.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract.  Author URL.  Full text.
Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM, Weedon MN, et al (2014). Another explanation for apparent epistasis. Nature, 514(7520), E3-E5. Author URL.  Full text.
Almasy L, Dyer TD, Peralta JM, Jun G, Wood AR, Fuchsberger C, Almeida MA, Kent JW, Fowler S, Blackwell TW, et al (2014). Data for Genetic Analysis Workshop 18: human whole genome sequence, blood pressure, and simulated phenotypes in extended pedigrees. BMC Proc, 8(Suppl 1). Abstract.  Author URL.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, et al (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46(11), 1173-1186. Abstract.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, et al (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet, 46(11), 1173-1186. Abstract.  Author URL.  Full text.
Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MCY, Prokopenko I, et al (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. NATURE GENETICS, 46(3), 234-+. Author URL.
Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R, Ferreira T, Fall T, Graff M, Justice AE, et al (2014). Quality control and conduct of genome-wide association meta-analyses. Nat Protoc, 9(5), 1192-1212. Abstract.  Author URL.
Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, Manning AK, Hartl C, Agarwala V, et al (2014). Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 111(36), 13127-13132. Abstract.
Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, et al (2013). Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Medicine, 10(2). Abstract.  Full text.
Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, et al (2013). Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes, 62(6), 2141-2150. Abstract.  Author URL.
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45(5), 501-512. Abstract.
Wood AR, Perry JRB, Tanaka T, Hernandez DG, Zheng H-F, Melzer D, Gibbs JR, Nalls MA, Weedon MN, Spector TD, et al (2013). Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One, 8(5). Abstract.  Author URL.  Full text.
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics, 9(6). Abstract.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract.  Author URL.  Full text.
Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, et al (2012). A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genetics, 8(7). Abstract.  Full text.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, et al (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491-501. Abstract.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu Y-H, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, et al (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics
Morris AP, Ferreira T, Mahajan A, Prokopenko I, Kumar A, Lagou V, Lindgren CM, Rayner NW, Wiltshire S, Dimas AS, et al (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981-990. Abstract.
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, et al (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. NATURE GENETICS, 44(9), 981-+. Author URL.
Islam M, Jafar TH, Wood AR, De Silva NMG, Caulfield M, Chaturvedi N, Frayling TM (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. Diabetologia, 1-12.
Islam M, Jafar TH, Wood AR, De Silva NMG, Caulfield M, Chaturvedi N, Frayling TM (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. DIABETOLOGIA, 55(8), 2193-2204. Author URL.
Scott RA, Chu AY, Grarup N, Manning AK, Hivert M-F, Shungin D, Toenjes A, Yesupriya A, Barnes D, Bouatia-Naji N, et al (2012). No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels. DIABETES, 61(5), 1291-1296. Author URL.
Dastani Z, Hivert MF, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, et al (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genetics, 8(3). Abstract.
Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.  Full text.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen M-H, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, et al (2011). Multiple Loci Are Associated with White Blood Cell Phenotypes. PLOS GENETICS, 7(6). Author URL.
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Maegi R, et al (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. NATURE GENETICS, 42(11), 937-U53. Author URL.
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, et al (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467(7317), 832-838. Abstract.  Author URL.
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Maegi R, et al (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. NATURE GENETICS, 42(11), 949-U160. Author URL.
ANDREW W, ANDREW NV (1948). Age changes in the deep cervical lymph nodes of 100 Wistar Institute rats. Am J Anat, 82(1), 105-165. Author URL.

Conferences

van Leeuwen N, Wood AR, Jackson A, Jonsson A, Wang N, Smith U, Vilarino LB, Stancakova A, Walker M, Hanson R, et al (2015). A genome wide association study of IVGTT based measures of first phase insulin secretion reveals new physiology of known and novel variants.  Author URL.

Publications by year


In Press

Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (In Press). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics Full text.
Frayling TM, Tyrrell J (In Press). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal Full text.
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, et al (In Press). The genetic architecture of type 2 diabetes. Nature, 536(7614), 41-47. Abstract.  Author URL.

2017

Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol Abstract.  Author URL.  Full text.
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, et al (2017). Rare and low-frequency coding variants alter human adult height. Nature, 542(7640), 186-190. Abstract.  Author URL.  Full text.

2016

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, Teumer A, Kang HM, Fuchsberger C, Danecek P, Sharp K, et al (2016). A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet, 48(10), 1279-1283. Abstract.  Author URL.  Full text.
Chen G-B, Lee SH, Robinson MR, Trzaskowski M, Zhu Z-X, Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, et al (2016). Across-cohort QC analyses of GWAS summary statistics from complex traits. Eur J Hum Genet, 25(1), 137-146. Abstract.  Author URL.
Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, Cavadino A, Paternoster L, Armstrong LL, De Silva NMG, et al (2016). Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA, 315(11), 1129-1129. Full text.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract.  Author URL.  Full text.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract.  Author URL.  Full text.
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract.  Author URL.  Full text.
Kilpeläinen TO, Carli JFM, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, et al (2016). Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. Nat Commun, 7 Abstract.  Author URL.
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract.  Author URL.
Almeida M, Blondell L, Peralta JM, Kent JW, Jun G, Teslovich TM, Fuchsberger C, Wood AR, Manning AK, Frayling TM, et al (2016). Independent test assessment using the extreme value distribution theory. BMC Proc, 10(Suppl 7), 245-249. Abstract.  Author URL.
Blangero J, Teslovich TM, Sim X, Almeida MA, Jun G, Dyer TD, Johnson M, Peralta JM, Manning A, Wood AR, et al (2016). Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19. BMC Proc, 10(Suppl 7), 71-77. Abstract.  Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet Abstract.  Author URL.  Full text.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract.  Author URL.  Full text.

2015

van Leeuwen N, Wood AR, Jackson A, Jonsson A, Wang N, Smith U, Vilarino LB, Stancakova A, Walker M, Hanson R, et al (2015). A genome wide association study of IVGTT based measures of first phase insulin secretion reveals new physiology of known and novel variants.  Author URL.
Yaghootkar H, Stancáková A, Freathy RM, Vangipurapu J, Weedon MN, Xie W, Wood AR, Ferrannini E, Mari A, Ring SM, et al (2015). Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion. Diabetes, 64(6), 2279-2285. Abstract.  Author URL.  Full text.
Pers TH, Karjalainen JM, Chan Y, Westra H-J, Wood AR, Yang J, Lui JC, Vedantam S, Gustafsson S, Esko T, et al (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun, 6 Abstract.  Author URL.
Westra H-J, Arends D, Esko T, Peters MJ, Schurmann C, Schramm K, Kettunen J, Yaghootkar H, Fairfax BP, Andiappan AK, et al (2015). Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet, 11(5). Abstract.  Author URL.
Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I, Nutile T, Jackson AU, Schurmann C, Smith AV, Zhang W, et al (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523(7561), 459-462. Abstract.  Author URL.
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, et al (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47(12), 1415-1425. Abstract.
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, et al (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet, 47(12), 1415-1425. Abstract.  Author URL.
Reppe S, Wang Y, Thompson WK, McEvoy LK, Schork AJ, Zuber V, LeBlanc M, Bettella F, Mills IG, Desikan RS, et al (2015). Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci. PLoS ONE, 10(12). Abstract.
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, et al (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518(7538), 197-206. Abstract.  Author URL.  Full text.
Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Esko T, Wood AR, Yang J, et al (2015). Mendelian randomization study of height and risk of colorectal cancer. Int J Epidemiol, 44(2), 662-672. Abstract.  Author URL.
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH, Fischer K, Justice AE, et al (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518(7538), 187-196. Abstract.  Author URL.  Full text.
Robinson MR, Hemani G, Medina-Gomez C, Mezzavilla M, Esko T, Shakhbazov K, Powell JE, Vinkhuyzen A, Berndt SI, Gustafsson S, et al (2015). Population genetic differentiation of height and body mass index across Europe. Nature Genetics, 47(11), 1357-1361. Abstract.
Robinson MR, Hemani G, Medina-Gomez C, Mezzavilla M, Esko T, Shakhbazov K, Powell JE, Vinkhuyzen A, Berndt SI, Gustafsson S, et al (2015). Population genetic differentiation of height and body mass index across Europe. Nature Genetics Abstract.
Locke JM, Hysenaj G, Wood AR, Weedon MN, Harries LW (2015). Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes, 64(4), 1484-1491. Abstract.  Author URL.  Full text.
Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, Lin H, Xu CS, Li Q, Shen J, Jun G, et al (2015). Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet, 24(5), 1504-1512. Abstract.  Author URL.  Full text.

2014

Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM, Weedon MN, et al (2014). Another explanation for apparent epistasis. Nature, 514(7520), E3-E5. Author URL.  Full text.
Almasy L, Dyer TD, Peralta JM, Jun G, Wood AR, Fuchsberger C, Almeida MA, Kent JW, Fowler S, Blackwell TW, et al (2014). Data for Genetic Analysis Workshop 18: human whole genome sequence, blood pressure, and simulated phenotypes in extended pedigrees. BMC Proc, 8(Suppl 1). Abstract.  Author URL.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, et al (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46(11), 1173-1186. Abstract.
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K, Luan J, Kutalik Z, et al (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet, 46(11), 1173-1186. Abstract.  Author URL.  Full text.
Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD, Ng MCY, Prokopenko I, et al (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. NATURE GENETICS, 46(3), 234-+. Author URL.
Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R, Ferreira T, Fall T, Graff M, Justice AE, et al (2014). Quality control and conduct of genome-wide association meta-analyses. Nat Protoc, 9(5), 1192-1212. Abstract.  Author URL.
Majithia AR, Flannick J, Shahinian P, Guo M, Bray MA, Fontanillas P, Gabriel SB, Manning AK, Hartl C, Agarwala V, et al (2014). Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proceedings of the National Academy of Sciences of the United States of America, 111(36), 13127-13132. Abstract.

2013

Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, et al (2013). Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts. PLoS Medicine, 10(2). Abstract.  Full text.
Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, Paananen J, et al (2013). Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes, 62(6), 2141-2150. Abstract.  Author URL.
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL, Croteau-Chonka DC, Day FR, et al (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45(5), 501-512. Abstract.
Wood AR, Perry JRB, Tanaka T, Hernandez DG, Zheng H-F, Melzer D, Gibbs JR, Nalls MA, Weedon MN, Spector TD, et al (2013). Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One, 8(5). Abstract.  Author URL.  Full text.
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T, Mägi R, Li S, et al (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics, 9(6). Abstract.
Morrison FS, Locke JM, Wood AR, Tuke M, Pasko D, Murray A, Frayling T, Harries LW (2013). The splice site variant rs11078928 may be associated with a genotype-dependent alteration in expression of GSDMB transcripts. BMC Genomics, 14 Abstract.  Author URL.  Full text.

2012

Coviello AD, Haring R, Wellons M, Vaidya D, Lehtimäki T, Keildson S, Lunetta KL, He C, Fornage M, Lagou V, et al (2012). A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation. PLoS Genetics, 8(7). Abstract.  Full text.
Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, Nambi V, Lamina C, Schillert A, Coassin S, Bis JC, et al (2012). Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circulation: Cardiovascular Genetics, 5(1), 100-112. Abstract.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, et al (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics, 44(5), 491-501. Abstract.
Estrada K, Styrkarsdottir U, Evangelou E, Hsu Y-H, Duncan EL, Ntzani EE, Oei L, Albagha OME, Amin N, Kemp JP, et al (2012). Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nature Genetics
Morris AP, Ferreira T, Mahajan A, Prokopenko I, Kumar A, Lagou V, Lindgren CM, Rayner NW, Wiltshire S, Dimas AS, et al (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44(9), 981-990. Abstract.
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, et al (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. NATURE GENETICS, 44(9), 981-+. Author URL.
Islam M, Jafar TH, Wood AR, De Silva NMG, Caulfield M, Chaturvedi N, Frayling TM (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. Diabetologia, 1-12.
Islam M, Jafar TH, Wood AR, De Silva NMG, Caulfield M, Chaturvedi N, Frayling TM (2012). Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis. DIABETOLOGIA, 55(8), 2193-2204. Author URL.
Scott RA, Chu AY, Grarup N, Manning AK, Hivert M-F, Shungin D, Toenjes A, Yesupriya A, Barnes D, Bouatia-Naji N, et al (2012). No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels. DIABETES, 61(5), 1291-1296. Author URL.
Dastani Z, Hivert MF, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, et al (2012). Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genetics, 8(3). Abstract.

2011

Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, Harries LW, Chong S, Moore M, Weedon MN, Guralnik JM, et al (2011). Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet, 20(20), 4082-4092. Abstract.  Author URL.  Full text.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract.  Author URL.
Nalls MA, Couper DJ, Tanaka T, van Rooij FJA, Chen M-H, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, et al (2011). Multiple Loci Are Associated with White Blood Cell Phenotypes. PLOS GENETICS, 7(6). Author URL.

2010

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Allen HL, Lindgren CM, Luan J, Maegi R, et al (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. NATURE GENETICS, 42(11), 937-U53. Author URL.
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, Willer CJ, Jackson AU, Vedantam S, Raychaudhuri S, et al (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467(7317), 832-838. Abstract.  Author URL.
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Maegi R, et al (2010). Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. NATURE GENETICS, 42(11), 949-U160. Author URL.

1948

ANDREW W, ANDREW NV (1948). Age changes in the deep cervical lymph nodes of 100 Wistar Institute rats. Am J Anat, 82(1), 105-165. Author URL.

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