COLLEGE OF MEDICINE AND HEALTH
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Dr Adam Smith

Laboratory Manager / Postdoctoral Research Fellow

 01392 406753

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Adam graduated in Medical Sciences at the University of Exeter College of Medicine and Health, in 2014, this was where he found a particular interest in genetics and neurology. He spent a year as an associate genetic technician for the Royal Devon and Exeter Genetic NHS service as part of his degree. Since then he has undertaken a PhD under the supervision of Dr Katie Lunnon and Professor Jonathan Mill. This work defined the extent of various epigenetic changes in the ANK1 gene in Alzheimer’s disease, relating this information to both levels of gene expression and characteristic measures of disease stage. He completed my PhD in June 2017 and his first postdoc within the same team which looked to explore the epigenetic similarities between Alzheimer's and Parkinson's disease, ending in March 2020. He is now laboratory manager for the Dementia Genomics group and is involved in many studies including the epigenetic regulation of mitochondria in Dementia.

Qualifications

  • BSc (Hons) Medical Science
  • PhD (Medical Studies)

Research

Research projects

  • Overlap in epigenetic profiles of different Dementias, specifically Alzheimer’s disease and Parkinson’s disease.
  • The contribution of epigenetic marks to mitochondrial disfunction in Alzheimer’s disease.

 


Grants/Funding

  • 08/2019                      Pyrosequencer for quantitative DNA modification profiling in Dementia (Co-Applicant) ARUK
  • 12/2018                      Functional characterization of ANK1 in mouse brain (PI) ARUK Network Centre
  • 03/2018                      Identifying specific epigenetic signatures for dementia (Co-Applicant)     BRACE         
  • 05/2015                      Optimising flow cytometry to allow cell specific analyses in post-mortem dementia brain. (PI)        ARUK Network Centre     
  • 09/2014                      PhD Studentship Functional characterisation of ANK1, a novel gene implicated (Co-Applicant) BRACE

Teaching

Supervision / Group

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