Professor William Henley
Professor of Medical Statistics
W.E.Henley@exeter.ac.uk
6088
+44 (0) 1392 726088
Overview
William Henley is Professor of Medical Statistics at the University of Exeter Medical School. He leads medical statistics across the Medical School, and is Head of the Health Statistics Group.
Qualifications
- BA (Hons) Mathematics (University of Oxford)
- MSc Statistics with Applications in Medicine (University of Southampton)
- PhD Applied Statistics (The Open University)
Career
William has worked as an applied statistician for over 20 years and has broad experience of statistical consultancy in academia and industry. He received his undergraduate training in Mathematics at the University of Oxford, before studying for a PhD at the Open University on statistical methods for credit scoring, under the supervision of Professor David Hand. William has held postdoctoral positions in statistical epidemiology at the University of Oxford and the Animal Health Trust. Prior to joining the University of Exeter, he was Associate Professor (Reader) in Statistics in the Centre for Health and Environmental Statistics at Plymouth University. In 2010, he was seconded to the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care for the South West Peninsula (PenCLAHRC). He was appointed to a Chair in Medical Statistics at UEMS in May 2012.
Research group links
Research
Research interests
- Analysis of longitudinal, multilevel and survival data
- Quasi-experimental analytic methods for strengthening causal inference from observational studies
- Design and analysis of cohort and other epidemiological studies
- Epidemiology of ageing, disability and chronic disease
- Statistical methods in bioinformatics
A current focus of his research is on the development and application of methodology for evaluating medical treatments using observational patient data. His collaborations include providing statistical leadership for the Exeter component of the Healthy Ageing theme of the NIHR National School for Public Health. Another growing area of research interest is the development of a statistical framework for treatment stratification for chronic diseases such as type 2 diabetes.
Prof Henley gives an overview of his research into ways of using data to measure the effectiveness and safety of medical treatments, in the video below.
Publications
Journal articles
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D, Henley W (In Press). Adjusting for unmeasured confounding in non-randomised longitudinal studies: a methodological review. Journal of Clinical Epidemiology
Parker C, Tejerina-Arreal M, Henley W, Goodman R, Logan S, Ford T (In Press). Are children with unrecognised psychiatric disorders being excluded from school? a secondary analysis of the British Child and Adolescent Mental Health Surveys 2004 and 2007. Psychological Medicine
Rodgers LR, weedon MN, Henley WE, Hattersley AT, Shields BM (In Press). Cohort profile for the MASTERMIND study: Using the Clinical Practice Research Datalink (CPRD) to investigate stratification of response to treatment in patients with Type 2 diabetes. BMJ Open
Dennis J, Shields B, Jones A, Pearson E, Hattersley A, Henley W (In Press). Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: a joint modelling approach. Clinical Epidemiology
Byng R, Kirkpatrick T, Lennox C, Warren FC, Anderson R, Brand SL, Callaghan L, Carroll L, Durcan G, Gill L, et al (In Press). Evaluation of a complex intervention for prisoners
with common mental health problems, near to and
after release: the Engager randomised
controlled trial. British Journal of Psychiatry Abstract.
Williams A, Henley W, Frank J (In Press). Impact of abolishing prescription fees in Scotland on hospital admissions and prescribed medicines: an interrupted time series evaluation. BMJ Open Abstract.
Creese B, Khan Z, Henley W, O'Dwyer S, Corbett A, Vasconcelos Da Silva M, Mills K, Wright N, Testad I, Aarsland D, et al (In Press). Loneliness, physical activity and mental health during Covid-19: a longitudinal analysis of depression and anxiety in adults over 50 between 2015 and 2020. International Psychogeriatrics
Trick LV, Watkins E, Henley W, Gandhi M, Dickens CM (In Press). Perservative negative thinking predicts depression in people with acute coronary syndrome. General Hospital Psychiatry
Zirk-Sadowski J, Masoli J, Strain WD, Delgado J, Henley W, Hamilton W, Melzer D, Ble A (In Press). Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients. The American Journal of Gastroenterology (Elsevier)
Streeter A, Rodgers LR, Hamilton F, Masoli JAH, Ble A, Hamilton WT, Henley W (In Press). Real-world effectiveness of pneumococcal vaccination in older adults: cohort study using the UK Clinical Practice Research Datalink. PLoS ONE
Ford TJ, Parker C, Salim J, Goodman R, Logan S, Henley W (In Press). The Relationship between Exclusion from School and Mental Health: a Secondary Analysis of the British Child and Adolescent Mental Health Surveys 2004 and 2007. Psychological Medicine
Dennis J, Henley W, McGovern A, Farmer A, Sattar N, Holman R, Pearson E, Hattersley A, Shields B, Jones AG, et al (In Press). Time trends in prescribing of type 2 diabetes drugs, glycemic response and risk factors: a retrospective analysis of primary care data, 2010-2017 Running title: Prescribing and patient outcomes in type 2 diabetes. Diabetes, Obesity and Metabolism
McGovern A, Shields B, Hattersley A, Pearson E, Jones AG (In Press). What to do with diabetes therapies when HbA1c lowering is inadequate: add, switch, or continue? a MASTERMIND study. BMC Medicine
Ford TJ, Paget A, Parker C, Heron J, Logan S, Henley W, EMOMND A (In Press). Which children and young people are excluded from school? Findings from a large British birth cohort study, the Avon Longitudinal Study of Parents and Children (ALSPAC). Child: Care, Health and Development
McDermid J, Henley W, Corbett A, Williams G, Fossey J, Clare L, Fox C, Aarsland D, Khan Z, Soto M, et al (2024). Impact of the iWHELD digital person-centered care program on quality of life, agitation and psychotropic medications in people with dementia living in nursing homes during the COVID-19 pandemic: a randomized controlled trial. Alzheimers Dement, 20(3), 1797-1806. Abstract. Author URL.
Rayman G, Page E, Hodgson S, Henley W, WR Briggs T, Gray WK (2024). Improving the outcomes for people with diabetes undergoing surgery: an observational study of the Improving the Peri-operative Pathway of People with Diabetes (IP3D) intervention. Diabetes Research and Clinical Practice, 207, 111062-111062.
Price D, Henley W, Cançado J, Fabbri L, Kerstjens H, Papi A, Roche N, Şen E, Singh D, Vogelmeier C, et al (2024). Risk of Pneumonia in Patients with COPD Initiating Fixed Dose Inhaled Corticosteroid (ICS) / Long-Acting Bronchodilator (LABD) Formulations Containing Extrafine Beclometasone Dipropionate versus Patients Initiating LABD Without ICS. Pragmatic and Observational Research, Volume 15, 1-16.
Watkins LV, Ashby S, Hanna J, Henley W, Laugharne R, Shankar R (2023). An evidence-based approach to provide essential and desirable components to develop surveys on Sudden Unexpected Death in Epilepsy (SUDEP) for doctors: a focused review. Seizure, 106, 14-21. Abstract. Author URL.
Walker S, Goodfellow H, Pookarnjanamorakot P, Murray E, Bindman J, Blandford A, Bradbury K, Cooper B, Hamilton FL, Hurst JR, et al (2023). Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study. BMJ Open, 13(6), e069217-e069217. Abstract.
Perez-de-Llano L, Scelo G, Canonica GW, Chen W, Henley W, Larenas-Linnemann D, Peters MJ, Pfeffer PE, Tran TN, Ulrik CS, et al (2023). Impact of pre-biologic impairment on meeting domain-specific biologic responder definitions in patients with severe asthma. Ann Allergy Asthma Immunol Abstract. Author URL.
Sun JJ, Watkins L, Henley W, Laugharne R, Angus-Leppan H, Sawhney I, Shahidi MM, Purandare K, Eyeoyibo M, Scheepers M, et al (2023). Mortality risk in adults with intellectual disabilities and epilepsy: an England and Wales case-control study. J Neurol, 270(7), 3527-3536. Abstract. Author URL.
Lennard S, Henley W, McLean B, Thompson T, Jadav M, Laugharne R, Shankar R (2023). Risk characteristics of alcohol and/or drug misuse in repeat emergency department attendees for seizures: a case–control study. Journal of Neurology, 270(10), 4914-4921.
Tromans S, Henley W, Summers I, Bilkey D, Datson J, Doherty N, Morpeth L, Benbow S, Jelbert R, Roy A, et al (2023). The psychological and social impact of the digital self-support system 'Brain in Hand' on autistic people: prospective cohort study in England and Wales. BJPsych Open, 9(3). Abstract. Author URL.
Byng R, Lennox C, Kirkpatrick T, Quinn C, Anderson R, Brand SL, Callaghan L, Carroll L, Durcan G, Gill L, et al (2022). Development and evaluation of a collaborative care intervention for male prison leavers with mental health problems: the Engager research programme. Programme Grants for Applied Research, 10(8), 1-46. Abstract.
Murray E, Goodfellow H, Bindman J, Blandford A, Bradbury K, Chaudhry T, Fernandez-Reyes D, Gomes M, Hamilton FL, Heightman M, et al (2022). Development, deployment and evaluation of digitally enabled, remote, supported rehabilitation for people with long COVID-19 (Living with COVID-19 Recovery): protocol for a mixed-methods study. BMJ Open, 12(2), e057408-e057408. Abstract.
Sun JJ, Perera B, Henley W, Angus-Leppan H, Sawhney I, Watkins L, Purandare KN, Eyeoyibo M, Scheepers M, Lines G, et al (2022). Epilepsy related multimorbidity, polypharmacy and risks. in adults with intellectual disabilities: a national study. Journal of Neurology, 269(5), 2750-2760.
Sun JJ, Perera B, Henley W, Angus-Leppan H, Sawhney I, Watkins L, Purandare KN, Eyeoyibo M, Scheepers M, Lines G, et al (2022). Epilepsy related multimorbidity, polypharmacy and risks in adults with intellectual disabilities: a national study (Jan, 10.1007/s00415-021-10938-3, 2022). JOURNAL OF NEUROLOGY, 269(5), 2761-2761. Author URL.
Streeter AJ, Rodgers LR, Hamilton F, Masoli JAH, Blé A, Hamilton WT, Henley WE (2022). Influenza vaccination reduced myocardial infarctions in United Kingdom older adults: a prior event rate ratio study. Journal of Clinical Epidemiology, 151, 122-131.
Price DB, Henley W, Cançado JED, Fabbri LM, Kerstjens HA, Papi A, Roche N, Şen E, Singh D, Vogelmeier CF, et al (2022). Interclass Difference in Pneumonia Risk in COPD Patients Initiating Fixed Dose Inhaled Treatment Containing Extrafine Particle Beclometasone versus Fine Particle Fluticasone [Corrigendum]. International Journal of Chronic Obstructive Pulmonary Disease, 17, 489-490.
Price DB, Henley W, Cançado JED, Fabbri LM, Kerstjens HAM, Papi A, Roche N, Şen E, Singh D, Vogelmeier CF, et al (2022). Interclass Difference in Pneumonia Risk in COPD Patients Initiating Fixed Dose Inhaled Treatment Containing Extrafine Particle Beclometasone versus Fine Particle Fluticasone. Int J Chron Obstruct Pulmon Dis, 17, 355-370. Abstract. Author URL.
Weston L, Rybczynska-Bunt S, Quinn C, Lennox C, Maguire M, Pearson M, Stirzaker A, Durcan G, Stevenson C, Graham J, et al (2022). Interrogating intervention delivery and participants’ emotional states to improve engagement and implementation: a realist informed multiple case study evaluation of Engager. PLOS ONE, 17(7), e0270691-e0270691. Abstract.
Shields BM, Dennis JM, Angwin CD, Warren F, Henley WE, Farmer AJ, Sattar N, Holman RR, Jones AG, Pearson ER, et al (2022). Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study. Nature Medicine, 29(2), 376-383.
Lennard S, Henley W, McLean B, Allard J, Parrett M, Jadav M, Laugharne R, Shankar R (2022). Seizures and emergency department: characteristics and factors of repeat adult attendees. Journal of Neurology, 269(7), 3770-3778.
Watkins LV, Henley W, Sun JJ, Perera B, Angus-Leppan H, Sawhney I, Purandare K, Eyeoyibo M, Scheepers M, Lines G, et al (2022). Tackling increased risks in older adults with intellectual disability and epilepsy: Data from a national multicentre cohort study. Seizure: European Journal of Epilepsy, 101, 15-21.
Ross JAD, Barron E, McGough B, Valabhji J, Daff K, Irwin J, Henley WE, Murray E (2022). Uptake and impact of the English National Health Service digital diabetes prevention programme: observational study. BMJ Open Diabetes Res Care, 10(3). Abstract. Author URL.
Dennis JM, Young KG, McGovern AP, Mateen BA, Vollmer SJ, Simpson MD, Henley WE, Holman RR, Sattar N, Pearson ER, et al (2021). Derivation and validation of a type 2 diabetes treatment selection algorithm for SGLT2-inhibitor and DPP4-inhibitor therapies based on glucose-lowering efficacy: cohort study using trial and routine clinical data. Abstract.
Strain WD, Elyas S, Wedge N, Mounce L, Henley W, James M, Shore AC (2021). Evaluation of microalbuminuria as a prognostic indicator after a TIA or minor stroke in an outpatient setting: the prognostic role of microalbuminuria in TIA evolution (ProMOTE) study. BMJ Open, 11(9), e043253-e043253. Abstract.
Rodgers LR, Streeter AJ, Lin N, Hamilton W, Henley WE (2021). Impact of influenza vaccination on amoxicillin prescriptions in older adults: a retrospective cohort study using primary care data. PLOS ONE, 16(1), e0246156-e0246156. Abstract.
Perera B, Chen J, Korb L, Borakati A, Courtenay K, Henley W, Tromans S, Shankar R (2021). Patterns of comorbidity and psychopharmacology in adults with intellectual disability and attention deficit hyperactivity disorder: an UK national cross-sectional audit. Expert Opinion on Pharmacotherapy, 22(8), 1071-1078.
Mostazir M, Taylor G, Henley WE, Watkins ER, Taylor RS (2021). Per-Protocol analyses produced larger treatment effect sizes than intention to treat: a meta-epidemiological study. J Clin Epidemiol, 138, 12-21. Abstract. Author URL.
McCabe J, McLean B, Henley W, Harris C, Cheatle K, Ashby S, Shankar R (2021). Sudden Unexpected Death in Epilepsy (SUDEP) and seizure safety: Modifiable and non-modifiable risk factors differences between primary and secondary care. Epilepsy & Behavior, 115, 107637-107637.
Hamilton F, Arnold D, Henley W, Payne RA (2020). Aspirin reduces cardiovascular events in patients with pneumonia: a prior event rate ratio analysis in a large primary care database. European Respiratory Journal, 57(2), 2002795-2002795. Abstract.
Perera B, Laugharne R, Henley W, Zabel A, Lamb K, Branford D, Courtanay K, Alexander R, Purandare K, Wijeratne A, et al (2020). COVID-19 deaths in people with intellectual disability in the UK and Ireland: descriptive study. BJPsych Open, 6(6). Abstract.
Tejerina-Arreal M, Parker C, Paget A, Henley W, Logan S, Emond A, Ford T (2020). Child and adolescent mental health trajectories in relation to exclusion from school from the Avon Longitudinal Study of Parents and Children. Child and Adolescent Mental Health, 25(4), 217-223. Abstract.
Allard J, Lawthom C, Henley W, Mclean B, Hudson S, Tittensor P, Rajakulendran S, Ellawela S, Pace A, Shankar R, et al (2020). Eslicarbazepine acetate response in intellectual disability population versus general population. Acta Neurologica Scandinavica, 143(3), 256-260.
Allard J, Henley W, Snoeijen‐Schouwenaars F, Ool J, Tan I, Jurgen Schelhaas H, Majoie MHJM, Hudson S, McLean B, Shankar R, et al (2020). European perspective of perampanel response in people with Intellectual Disability. Acta Neurologica Scandinavica, 142(3), 255-259.
Burrows L, Lennard S, Hudson S, McLean B, Jadav M, Henley W, Sander JW, Shankar R (2020). Exploring epilepsy attendance at the emergency department and interventions which may reduce unnecessary attendances: a scoping review. Seizure, 76, 39-46. Abstract. Author URL.
Allard J, Henley W, Mclean B, Sellers A, Hudson S, Rajakulendran S, Pace A, Pashley S, Maguire M, Mohan M, et al (2020). Lacosamide in the general population and in people with intellectual disability: Similar responses?. Seizure, 76, 161-166.
Rodgers LR, Dennis JM, Shields BM, Mounce L, Fisher I, Hattersley AT, Henley WE (2020). Prior event rate ratio adjustment produced estimates consistent with randomized trial: a diabetes case study. Journal of Clinical Epidemiology, 122, 78-86.
McGovern AP, Hogg M, Shields BM, Sattar NA, Holman RR, Pearson ER, Hattersley AT, Jones AG, Dennis JM (2020). Risk factors for genital infections in people initiating SGLT2 inhibitors and their impact on discontinuation. BMJ Open Diabetes Research & Care, 8(1), e001238-e001238. Abstract.
Sun JJ, Perera B, Henley W, Ashby S, Shankar R (2020). Seizure and Sudden Unexpected Death in Epilepsy (SUDEP) characteristics in an urban UK intellectual disability service. Seizure, 80, 18-23.
Xiao Z, Henley W, Boyle C, Gao Y, Dillon J (2020). The Face Mask and the Embodiment of Stigma. Abstract. Author URL.
Angwin C, Jenkinson C, Jones A, Jennison C, Henley W, Farmer A, Sattar N, Holman RR, Pearson E, Shields B, et al (2020). TriMaster: randomised double-blind crossover study of a DPP4 inhibitor, SGLT2 inhibitor and thiazolidinedione as second-line or third-line therapy in patients with type 2 diabetes who have suboptimal glycaemic control on metformin treatment with or without a sulfonylurea—a MASTERMIND study protocol. BMJ Open, 10(12), e042784-e042784. Abstract.
Baker J, Libretto T, Henley W, Zeman A (2019). A Longitudinal Study of Epileptic Seizures in Alzheimer's Disease. Front Neurol, 10 Abstract. Author URL.
Mostazir M, Taylor RS, Henley W, Watkins E (2019). An overview of statistical methods for handling nonadherence to intervention protocol in randomized control trials: a methodological review. J Clin Epidemiol, 108, 121-131. Abstract. Author URL.
Masoli J, Correa Delgado J, Bowman K, Strain W, Henley W, Melzer D (2019). Association of blood pressure with clinical outcomes in older adults with chronic kidney disease. Age and Ageing
Dennis JM, Shields BM, Henley WE, Jones AG, Hattersley AT (2019). Clusters provide a better holistic view of type 2 diabetes than simple clinical features - Authors' reply. Lancet Diabetes Endocrinol, 7(9). Author URL.
Dennis J, Shields B, Henley W, Jones A, Hattersley A (2019). Disease progression and treatment response in data-driven subgroups of type 2 diabetes compared to models based on simple clinical features: an evaluation using clinical trial data. Lancet Diabetes and Endocrinology
Murray E, Daff K, Lavida A, Henley W, Irwin J, Valabhji J (2019). Evaluation of the digital diabetes prevention programme pilot: uncontrolled mixed-methods study protocol. BMJ Open, 9(5). Abstract. Author URL.
Sharpe RA, Machray KE, Fleming LE, Taylor T, Henley W, Chenore T, Hutchcroft I, Taylor J, Heaviside C, Wheeler BW, et al (2019). Household energy efficiency and health: Area-level analysis of hospital admissions in England. Environment International, 133 Abstract.
Cocksedge KA, Guliani J, Henley W, Anderson T, Roberts S, Reed L, Skinnard D, Fisher S, Chapman B, Willcox J, et al (2019). Local radio to promote mental health awareness: a public health initiative. BJPsych Open, 5(4). Abstract.
Ford T, Kenchington R, Norman S, Hancock J, Smalley A, Henley W, Russell G, Hayes J, Logan S (2019). The agreement between the referrer, practitioner and research diagnosis of autistic spectrum conditions among children attending child and adolescent mental health services. European Child and Adolescent Psychiatry, 28(9), 1253-1264. Abstract.
Baker J, Libretto T, Henley W, Zeman A (2019). The prevalence and clinical features of epileptic seizures in a memory clinic population. Seizure, 71, 83-92.
Lines G, Henley W, Winterhalder R, Shankar R (2018). Awareness, attitudes, skills and training needs of psychiatrists working with adults with intellectual disability in managing epilepsy. Seizure, 63, 105-112. Abstract. Author URL.
Delgado J, Bowman K, Ble A, Masoli J, Han Y, Henley W, Welsh S, Kuchel GA, Ferrucci L, Melzer D, et al (2018). Blood Pressure Trajectories in the 20 Years Before Death. JAMA Intern Med, 178(1), 93-99. Abstract. Author URL.
Shankar R, Henley W, Boland C, Laugharne R, McLean BN, Newman C, Hanna J, Ashby S, Walker MC, Sander JW, et al (2018). Decreasing the risk of sudden unexpected death in epilepsy: structured communication of risk factors for premature mortality in people with epilepsy. Eur J Neurol, 25(9), 1121-1127. Abstract. Author URL.
Jalihal V, Shankar R, Henley W, Parrett M, Tittensor P, McLean BN, Ahmed A, Sander JW (2018). Eslicarbazepine acetate as a replacement for levetiracetam in people with epilepsy developing behavioral adverse events. Epilepsy and Behavior, 80, 365-369. Abstract.
Kirkpatrick T, Lennox C, Taylor R, Anderson R, Maguire M, Haddad M, Michie S, Owens C, Durcan G, Stirzaker A, et al (2018). Evaluation of a complex intervention (Engager) for prisoners with common mental health problems, near to and after release: study protocol for a randomised controlled trial. BMJ Open, 8(2). Abstract. Author URL.
Longridge R, Norman S, Henley W, Newlove Delgado T, Ford T (2018). Investigating the agreement between the clinician and research diagnosis of attention deficit hyperactivity disorder and how it changes over time; a clinical cohort study. Child and Adolescent Mental Health, 24(2), 133-141. Abstract.
Dennis J, Shields B, Hill A, Knight B, McDonald T, Rodgers L, Weedon M, Henley W, Sattar N, Holman R, et al (2018). Precision medicine in Type 2 diabetes: Clinical markers of insulin resistance are associated with altered short- and long-term glycemic response to DPP-4 inhibitor therapy. Diabetes Care
Mounce LTA, Campbell JL, Henley WE, Tejerina Arreal MC, Porter I, Valderas JM (2018). Predicting Incident Multimorbidity. Ann Fam Med, 16(4), 322-329. Abstract. Author URL.
Zirk-Sadowski J, Masoli JA, Delgado J, Hamilton W, Strain WD, Henley W, Melzer D, Ble A (2018). Proton-Pump Inhibitors and Long-Term Risk of Community-Acquired Pneumonia in Older Adults. J Am Geriatr Soc, 66(7), 1332-1338. Abstract. Author URL.
Young C, Shankar R, Henley W, Rose A, Cheatle K, Sander JW (2018). SUDEP and seizure safety communication: Assessing if people hear and act. Epilepsy Behav, 86, 200-203. Abstract. Author URL.
Dennis JM, Henley WE, Weedon MN, Lonergan M, Rodgers LR, Jones AG, Hamilton WT, Sattar N, Janmohamed S, Holman RR, et al (2018). Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: a Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data. Diabetes Care, 41(9), 1844-1853. Abstract. Author URL.
Shankar R, Rowe C, Van Hoorne A, Henley W, Laugharne R, Cox D, Pande R, Roy A, Sander JW (2018). Under representation of people with epilepsy and intellectual disability in research. PLoS One
Gopalakrishna G, Langendam M, Scholten R, Bossuyt P, Leeflang M, Noel-Storr A, Thomas J, Marshall I, Wallace B, Whiting P, et al (2017). Erratum to: Methods for evaluating medical tests and biomarkers. Diagn Progn Res, 1 Abstract. Author URL.
Allard J, Shankar R, Henley W, Brown A, McLean B, Jadav M, Parrett M, Laugharne R, Noble AJ, Ridsdale L, et al (2017). Frequency and factors associated with emergency department attendance for people with epilepsy in a rural UK population. Epilepsy and Behavior, 68, 192-195. Abstract.
Burt J, Campbell J, Abel G, Aboulghate A, Ahmed F, Asprey A, Barry H, Beckwith J, Benson J, Boiko O, et al (2017). Improving patient experience in primary care: a multimethod programme of research on the measurement and improvement of patient experience. Programme Grants for Applied Research, 5(9), 1-452. Abstract.
Alsubaie M, Abbbott R, Dunn BD, Dickens C, Keil T, Henley W, Kuyken W (2017). Mechanisms of action in mindfulness-based cognitive therapy (MBCT) and mindfulness-based stress reduction (MBSR) in people with physical and/or psychological conditions: a systematic review. Clinical Psychology Review, 55, 74-91.
Bowman K, Delgado J, Henley WE, Masoli JA, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel GA, Ble A, et al (2017). Obesity in Older People with and Without Conditions Associated with Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol a Biol Sci Med Sci, 72(2), 203-209. Abstract. Author URL.
Shankar R, Henley W, Wehner T, Wiggans C, McLean B, Pace A, Mohan M, Sadler M, Doran Z, Hudson S, et al (2017). Perampanel in the general population and in people with intellectual disability: Differing responses. Seizure, 49, 30-35. Abstract. Author URL.
Ble A, Hughes PM, Delgado J, Masoli JA, Bowman K, Zirk-Sadowski J, Mujica Mota RE, Henley WE, Melzer D (2017). Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: a Quasi-Experimental Study. J Gerontol a Biol Sci Med Sci, 72(2), 243-250. Abstract. Author URL.
Pettit S, Qureshi A, Lee W, Stirzaker A, Gibson A, Henley W, Byng R (2017). Variation in referral and access to new psychological therapy services by age: an empirical quantitative study. Br J Gen Pract, 67(660), e453-e459. Abstract. Author URL.
Norman SM, Ford T, Henley W, Goodman R (2016). A comparison of parent reported outcome with experience of services. Journal of Children's Services, 11(2), 157-169. Abstract.
Hunter JG, Madden RG, Stone AM, Osborne N, Wheeler B, Vine L, Dickson A, Barlow M, Lewis J, Bendall RP, et al (2016). Coastal clustering of HEV; Cornwall, UK. Eur J Gastroenterol Hepatol, 28(3), 323-327. Abstract. Author URL.
Mounce LTA, Barry HE, Calitri R, Henley WE, Campbell J, Roland M, Richards S (2016). Establishing the validity of English GP Patient Survey items evaluating out-of-hours care. BMJ Qual Saf, 25(11), 842-850. Abstract. Author URL.
Ruth KS, Perry JRB, Henley WE, Melzer D, Weedon MN, Murray A (2016). Events in Early Life are Associated with Female Reproductive Ageing: a UK Biobank Study. Sci Rep, 6 Abstract. Author URL.
Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, et al (2016). Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics, 48(1), 1-11. Abstract. Author URL.
Lin NX, Henley WE (2016). Prior event rate ratio adjustment for hidden confounding in observational studies of treatment effectiveness: a pairwise Cox likelihood approach. Statistics in Medicine, 35(28), 5149-5169. Abstract.
Eyre V, Lang CC, Smith K, Jolly K, Davis R, Hayward C, Wingham J, Abraham C, Green C, Warren FC, et al (2016). Rehabilitation Enablement in Chronic Heart Failure-a facilitated self-care rehabilitation intervention in patients with heart failure with preserved ejection fraction (REACH-HFpEF) and their caregivers: rationale and protocol for a single-centre pilot randomised controlled trial. BMJ Open, 6(10). Abstract. Author URL.
Jones AG, Lonergan M, Henley WE, Pearson ER, Hattersley AT, Shields BM (2016). Should Studies of Diabetes Treatment Stratification Correct for Baseline HbA1c?. PLoS One, 11(4). Abstract. Author URL.
Abel A, Hayes AM, Henley W, Kuyken W (2016). Sudden gains in cognitive-behavior therapy for treatment-resistant depression: Processes of change. J Consult Clin Psychol, 84(8), 726-737. Abstract. Author URL.
Parker C, Marlow R, Kastner M, May F, Mitrofan O, Henley W, Ford T (2016). The "supporting kids, avoiding problems" (SKIP) study: Relationships between school exclusion, psychopathology, development and attainment - Case control study. Journal of Children's Services, 11(2), 91-110. Abstract.
Littlejohns TJ, Kos K, Henley WE, Kuźma E, Llewellyn DJ (2016). Vitamin D and Dementia. J Prev Alzheimers Dis, 3(1), 43-52. Abstract. Author URL.
Kuźma E, Soni M, Littlejohns TJ, Ranson JM, van Schoor NM, Deeg DJH, Comijs H, Chaves PHM, Kestenbaum BR, Kuller LH, et al (2016). Vitamin D and Memory Decline: Two Population-Based Prospective Studies. J Alzheimers Dis, 50(4), 1099-1108. Abstract. Author URL.
Littlejohns TJ, Kos K, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Kestenbaum BR, Kuller LH, Langa KM, et al (2016). Vitamin D and Risk of Neuroimaging Abnormalities. PLoS One, 11(5). Abstract. Author URL.
Ble A, Masoli JAH, Barry HE, Winder RE, Tavakoly B, Henley WE, Kuchel GA, Valderas JM, Melzer D, Richards SH, et al (2015). Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12. BMC Geriatr, 15 Abstract. Author URL.
Steel N, Hardcastle AC, Bachmann MO, Richards SH, Mounce LTA, Clark A, Lang I, Melzer D, Campbell JL (2015). Economic inequalities in burden of illness, diagnosis and treatment of five long-term conditions in England: panel study. BMJ Open, 4(10). Abstract.
Metcalf BS, Hosking J, Henley WE, Jeffery AN, Mostazir M, Voss LD, Wilkin TJ (2015). Erratum to: Physical activity attenuates the mid-adolescent peak in insulin resistance but by late adolescence the effect is lost: a longitudinal study with annual measures from 9-16 years (EarlyBird 66). Diabetologia, 58(12). Author URL.
Metcalf BS, Hosking J, Jeffery AN, Henley WE, Wilkin TJ (2015). Exploring the Adolescent Fall in Physical Activity: a 10-yr Cohort Study (EarlyBird 41). Med Sci Sports Exerc, 47(10), 2084-2092. Abstract. Author URL.
Williams AJ, Wyatt KM, Williams CA, Logan S, Henley WE (2015). Exploring the Potential of a School Impact on Pupil Weight Status: Exploratory Factor Analysis and Repeat Cross-Sectional Study of the National Child Measurement Programme. PLoS One, 10(12). Abstract. Author URL.
Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying S-X, et al (2015). Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol, 70, 37-45. Abstract. Author URL.
Melzer D, Tavakoly B, Winder RE, Masoli JAH, Henley WE, Ble A, Richards SH (2015). Much more medicine for the oldest old: trends in UK electronic clinical records. Age Ageing, 44(1), 46-53. Abstract. Author URL.
Mounce LTA, Steel N, Hardcastle AC, Henley WE, Bachmann MO, Campbell JL, Melzer D, Richards SH (2015). Patient characteristics predicting failure to receive indicated care for type 2 diabetes. Diabetes Research and Clinical Practice, 107(2), 247-258. Abstract.
Metcalf BS, Hosking J, Henley WE, Jeffery AN, Mostazir M, Voss LD, Wilkin TJ (2015). Physical activity attenuates the mid-adolescent peak in insulin resistance but by late adolescence the effect is lost: a longitudinal study with annual measures from 9-16 years (EarlyBird 66). Diabetologia, 58(12), 2699-2708. Abstract. Author URL.
Metcalf B, Hosking J, Henley W, Jeffery A, Mostazir M, Voss L, Wilkin T (2015). Research: Report: Physical Activity Attenuates Insulin Resistance, by Late Adolescence Effect is Lost. Children and Young People Now, 2015(20), 35-35.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2015). Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis, 44(4), 1231-1239. Abstract. Author URL.
Hardcastle AC, Mounce LTA, Richards SH, Bachmann MO, Clark A, Henley WE, Campbell JL, Melzer D, Steel N (2015). The dynamics of quality: a national panel study of evidence-based standards. Health Services and Delivery Research, 3(11), 1-128. Abstract.
Ble A, Delgado J, Bowman K, Masoli JA, Streeter A, Henley W, Melzer D (2015). USING ELECTRONIC MEDICAL RECORDS TO ESTIMATE THE EFFECTIVENESS OF STATINS IN PREVENTING CARDIOVASCULAR DISEASE AND ALL-CAUSE MORTALITY IN PEOPLE 75 AND OLDER. GERONTOLOGIST, 55, 26-26. Author URL.
Delgado J, Ble A, Bowman K, Masoli JA, Streeter A, Henley W, Melzer D (2015). USING ELECTRONIC MEDICAL RECORDS TO ESTIMATE THE EFFECTIVENESS OF STATINS IN PREVENTING THE INCIDENCE\ ONSET OF DEMENTIA IN PEOPLE 75 AND OLDER. GERONTOLOGIST, 55, 26-26. Author URL.
Paget A, Parker C, Henley W, Heron J, Ford T, Emond A (2015). Which children and young people are excluded from school? Findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). Lancet, 385 Suppl 1 Abstract. Author URL.
Masoli J, Winder R, Tavakoly B, Henley W, Ble A, Richards S, Melzer D (2014). 63. OVERDIAGNOSING AND MISSING THE POINT?. Age and Ageing, 43(suppl 2), ii19-ii19.
Williams AJ, Wyatt KM, Williams CA, Logan S, Henley WE (2014). A repeated cross-sectional study examining the school impact on child weight status. Prev Med, 64(100), 103-107. Abstract. Author URL.
Dutta A, Henley W, Robine JM, Llewellyn D, Langa KM, Wallace RB, Melzer D (2014). Aging children of long-lived parents experience slower cognitive decline. Alzheimer's and Dementia, 10(5), S315-S322. Abstract.
Anderson LJ, Henley W, Wyatt KM, Nikolaou V, Waldek S, Hughes DA, Lachmann RH, Logan S (2014). Effectiveness of enzyme replacement therapy in adults with late-onset Pompe disease: results from the NCS-LSD cohort study. J Inherit Metab Dis, 37(6), 945-952. Abstract. Author URL.
Jones AG, Shields BM, Hyde CJ, Henley WE, Hattersley AT (2014). Identifying good responders to glucose lowering therapy in type 2 diabetes: implications for stratified medicine. PLoS One, 9(10). Abstract. Author URL.
Last A, Henley W, Norman S, Goodman R, Ford T (2014). Innovations in Practice: Feasibility of the development and well-being assessment as an adjunct to clinical assessment in child and adolescent mental health services. Child and Adolescent Mental Health, 19(2), 142-146. Abstract.
Anderson LJ, Wyatt KM, Henley W, Nikolaou V, Waldek S, Hughes DA, Pastores GM, Logan S (2014). Long-term effectiveness of enzyme replacement therapy in Fabry disease: results from the NCS-LSD cohort study. J Inherit Metab Dis, 37(6), 969-978. Abstract. Author URL.
Anderson LJ, Henley W, Wyatt KM, Nikolaou V, Hughes DA, Waldek S, Logan S (2014). Long-term effectiveness of enzyme replacement therapy in adults with Gaucher disease: results from the NCS-LSD cohort study. J Inherit Metab Dis, 37(6), 953-960. Abstract. Author URL.
Anderson LJ, Henley W, Wyatt KM, Nikolaou V, Waldek S, Hughes DA, Pastores GM, Logan S (2014). Long-term effectiveness of enzyme replacement therapy in children with Gaucher disease: results from the NCS-LSD cohort study. J Inherit Metab Dis, 37(6), 961-968. Abstract. Author URL.
Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ (2014). SERUM LEPTIN AND RISK OF COGNITIVE DECLINE IN ELDERLY ITALIANS: a PROSPECTIVE COHORT STUDY. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 68, A4-A4. Author URL.
Steel N, Hardcastle AC, Clark A, Mounce LTA, Bachmann MO, Richards SH, Henley WE, Campbell JL, Melzer D (2014). Self-reported quality of care for older adults from 2004 to 2011: a cohort study. Age Ageing, 43(5), 716-720. Abstract. Author URL.
Henley WE, Anderson LJ, Wyatt KM, Nikolaou V, Anderson R, Logan S (2014). The NCS-LSD cohort study: a description of the methods and analyses used to assess the long-term effectiveness of enzyme replacement therapy and substrate reduction therapy in patients with lysosomal storage disorders. J Inherit Metab Dis, 37(6), 939-944. Abstract. Author URL.
Zahra D, Qureshi A, Henley W, Taylor R, Quinn C, Pooler J, Hardy G, Newbold A, Byng R (2014). The work and social adjustment scale: reliability, sensitivity and value. Int J Psychiatry Clin Pract, 18(2), 131-138. Abstract. Author URL.
Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PHM, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al (2014). Vitamin D and the risk of dementia and Alzheimer disease. Neurology, 83(10), 920-928. Abstract. Author URL.
Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ (2013). Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int, 59, 328-335. Abstract. Author URL.
Lin NX, Logan GS, Henley WE (2013). Bias and sensitivity analysis when estimating treatment effects from the Cox Model with omitted covariates. Biometrics
Lin NX, Logan S, Henley WE (2013). Bias and sensitivity analysis when estimating treatment effects from the cox model with omitted covariates. Biometrics, 69(4), 850-860. Abstract.
Ford T, Last A, Henley W, Norman S, Guglani S, Kelesidi K, Martin AM, Moran P, Latham-Cork H, Goodman R, et al (2013). Can standardized diagnostic assessment be a useful adjunct to clinical assessment in child mental health services? a randomized controlled trial of disclosure of the Development and Well-Being Assessment to practitioners. Social Psychiatry and Psychiatric Epidemiology, 48(4), 583-593. Abstract.
Harrison A, Scobie L, Crossan C, Parry R, Johnston P, Stratton J, Dickinson S, Ellis V, Hunter JG, Prescott OR, et al (2013). Hepatitis E seroprevalence in recipients of renal transplants or haemodialysis in southwest England: a case-control study. Journal of Medical Virology, 85(2), 266-271. Abstract.
Dutta A, Henley W, Robine J-M, Langa KM, Wallace RB, Melzer D (2013). Longer lived parents: protective associations with cancer incidence and overall mortality. J Gerontol a Biol Sci Med Sci, 68(11), 1409-1418. Abstract. Author URL.
Metcalf B, Henley W, Wilkin T (2013). Republished research: effectiveness of intervention on physical activity of children: systematic review and meta-analysis of controlled trials with objectively measured outcomes (EarlyBird 54). Br J Sports Med, 47(4). Author URL.
Shields BM, Henley W, Besser REJ, Hattersley AT, Ludvigsson J (2013). Response to Comment on: Besser et al. Lessons from the Mixed-Meal Tolerance Test: Use of 90-Minute and Fasting C-Peptide in Pediatric Diabetes. Diabetes Care 2013;36:195-201. DIABETES CARE, 36(12), E222-E222. Author URL.
Williams AJ, Henley WE, Williams CA, Hurst AJ, Logan S, Wyatt KM (2013). Systematic review and meta-analysis of the association between childhood overweight and obesity and primary school diet and physical activity policies. International Journal of Behavioural Nutrition and Physical Activity, 10
Mann J, Henley W, O'Mahen H, Ford T (2013). The reliability and validity of the Everyday Feelings Questionnaire in a clinical population. Journal of Affective Disorders, 148(2-3), 406-410. Abstract.
Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW, et al (2013). Towards a gene expression biomarker set for human biological age. Aging Cell, 12(2), 324-326. Abstract.
Dutta A, Henley W, Pilling LC, Wallace RB, Melzer D (2013). Uric acid measurement improves prediction of cardiovascular mortality in later life. J Am Geriatr Soc, 61(3), 319-326. Abstract. Author URL.
Metcalf B, Henley W, Wilkin T (2012). Authors' reply to Symonds. BMJ, 345
Harries LW, Pilling LC, Hernandez LDG, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D, et al (2012). CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell, 11(2), 262-268. Abstract. Author URL.
Hartley C, Donaldson D, Smith KC, Henley W, Lewis TW, Blott S, Mellersh C, Barnett KC (2012). Congenital keratoconjunctivitis sicca and ichthyosiform dermatosis in 25 Cavalier King Charles spaniel dogs. Part I: clinical signs, histopathology, and inheritance. Vet Ophthalmol, 15(5), 315-326. Abstract. Author URL.
Melzer D, Gates P, Osborn NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, et al (2012). Correction: Urinary Bisphenol a Concentration and Angiography-Defined Coronary Artery Stenosis. PLoS One, 7(11). Abstract. Author URL.
Metcalf B, Henley W, Wilkin T (2012). Effectiveness of intervention on physical activity of children: Systematic review and meta-analysis of controlled trials with objectively measured outcomes (EarlyBird 54). BMJ (Online), 345(7876). Abstract.
Keane FE, Gompels M, Bendall RP, Drayton R, Jennings L, Black J, Baragwanath G, Lin NX, Henley WE, Ngui S-L, et al (2012). Hepatitis E virus coinfection in patients with HIV infection. HIV MEDICINE, 13(1), 83-88. Author URL.
Metcalf B, Henley W, Wilkin T (2012). Keeping the customer satisfied reply. BMJ-BRITISH MEDICAL JOURNAL, 345 Author URL.
Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, et al (2012). Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res, 15(4), 395-404. Abstract. Author URL.
Melzer D, Dutta A, Henley W, Langa K, Wallace RB, Robine J (2012). MIDDLE-AGED OFFSPRING OF LONG LIVED PARENTS IN HRS. GERONTOLOGIST, 52, 414-414. Author URL.
Wyatt K, Henley W, Anderson L, Anderson R, Nikolaou V, Stein K, Klinger L, Hughes D, Waldek S, Lachmann R, et al (2012). The effectiveness and cost-effectiveness of enzyme and substrate replacement therapies: a longitudinal cohort study of people with lysosomal storage disorders. HEALTH TECHNOLOGY ASSESSMENT, 16(39), V-+. Author URL.
Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Luben R, Khaw K-T, Wareham NJ, et al (2012). Urinary bisphenol a concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation, 125(12), 1482-1490. Abstract. Author URL.
Melzer D, Gates P, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, et al (2012). Urinary bisphenol a concentration and angiography-defined coronary artery stenosis. PLoS One, 7(8). Abstract. Author URL.
Goodwin VA, Richards SH, Henley W, Ewings P, Taylor AH, Campbell JL (2011). An exercise intervention to prevent falls in people with Parkinson's disease: a pragmatic randomised controlled trial. Journal of Neurology, Neurosurgery and Psychiatry, 82(11), 1232-1238. Abstract.
Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, et al (2011). Bisphenol a exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect, 119(12), 1788-1793. Abstract. Author URL.
Rice NE, Lang IA, Henley W, Melzer D (2011). Common health predictors of early retirement: findings from the English Longitudinal Study of Ageing. Age Ageing, 40(1), 54-61. Abstract. Author URL.
Metcalf BS, Hosking J, Jeffery AN, Voss LD, Henley W, Wilkin TJ (2011). Fatness leads to inactivity, but inactivity does not lead to fatness: a longitudinal study in children (EarlyBird 45). Arch Dis Child, 96(10), 942-947. Abstract. Author URL.
Dalton HR, Bendall RP, Rashid M, Ellis V, Ali R, Ramnarace R, Stableforth W, Headdon W, Abbott R, McLaughlin C, et al (2011). Host risk factors and autochthonous hepatitis E infection. Eur J Gastroenterol Hepatol, 23(12), 1200-1205. Abstract. Author URL.
Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, et al (2011). Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell, 10(5), 868-878. Abstract. Author URL.
Hoyle MW, Henley W (2011). Improved curve fits to summary survival data: application to economic evaluation of health technologies. BMC Med Res Methodol, 11 Abstract. Author URL.
Dutta A, Henley W, Lang I, Llewellyn D, Guralnik J, Wallace RB, Melzer D (2011). Predictors of extraordinary survival in the Iowa established populations for epidemiologic study of the elderly: cohort follow-up to "extinction". J Am Geriatr Soc, 59(6), 963-971. Abstract. Author URL.
MacKichan F, Paterson C, Henley WE, Britten N (2011). Self-care in people with long term health problems: a community based survey. BMC Fam Pract, 12 Abstract. Author URL.
Dutta A, Henley W, Lang IA, Murray A, Guralnik J, Wallace RB, Melzer D (2011). The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet, 4(5), 542-548. Abstract. Author URL.
Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS (2010). Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey. Environ Health Perspect, 118(5), 686-692. Abstract. Author URL.
Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS (2010). Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. PLoS One, 5(1). Abstract. Author URL.
Rice NE, Lang IA, Henley W, Melzer D (2010). Baby boomers nearing retirement: the healthiest generation?. Rejuvenation Res, 13(1), 105-114. Abstract. Author URL.
Hosking J, Henley W, Metcalf BS, Jeffery AN, Voss LD, Wilkin TJ (2010). Changes in resting energy expenditure and their relationship to insulin resistance and weight gain: a longitudinal study in pre-pubertal children (EarlyBird 17). Clin Nutr, 29(4), 448-452. Abstract. Author URL.
Dalton HR, Bendall RP, Pritchard C, Henley W, Melzer D (2010). National mortality rates from chronic liver disease and consumption of alcohol and pig meat. Epidemiol Infect, 138(2), 174-182. Abstract. Author URL.
Cluett C, Brayne C, Clarke R, Evans G, Matthews F, Rubinsztein DC, Huppert F, Llewellyn DJ, Rice N, Henley W, et al (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging, 31(9), 1563-1568. Abstract. Author URL.
Murray RC, Deaton CM, Smith NC, Henley WE, Marlin DJ (2009). Neither age nor osteoarthritis is associated with synovial fluid antioxidant disturbance or depletion in the horse. Comparative Exercise Physiology, 6(3), 121-128. Abstract.
Parahyba MI, Stevens K, Henley W, Lang IA, Melzer D (2009). Reductions in disability prevalence among the highest income groups of older Brazilians. Am J Public Health, 99(1), 81-86. Abstract. Author URL.
Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, Miljkovic I, Zmuda JM, Li R, Tranah G, Harris T, et al (2009). The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet, 2(4), 347-353. Abstract. Author URL.
Melzer D, Perry JRB, Hernandez D, Corsi A-M, Stevens K, Rafferty I, Lauretani F, Murray A, Gibbs JR, Paolisso G, et al (2008). A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet, 4(5). Abstract. Author URL.
Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D (2008). Association of urinary bisphenol a concentration with medical disorders and laboratory abnormalities in adults. JAMA, 300(11), 1303-1310. Abstract. Author URL.
Ellis J, Logan S, Pumphrey R, Tan HK, Henley W, Edwards V, Moy R, Gilbert R (2008). Inequalities in provision of the Disability Living Allowance for Down syndrome. Arch Dis Child, 93(1), 14-16. Abstract. Author URL.
Edwards DS, Coyne K, Dawson S, Gaskell RM, Henley WE, Rogers K, Wood JLN (2008). Risk factors for time to diagnosis of feline upper respiratory tract disease in UK animal adoption shelters. Prev Vet Med, 87(3-4), 327-339. Abstract. Author URL.
Ellis JM, Tan HK, Gilbert RE, Muller DPR, Henley W, Moy R, Pumphrey R, Ani C, Davies S, Edwards V, et al (2008). Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial. BMJ, 336(7644), 594-597. Abstract. Author URL.
Blissitt KJ, Raisis AL, Adams VJ, Rogers KH, Henley WE, Young LE (2008). The effects of halothane and isoflurane on cardiovascular function in dorsally recumbent horses undergoing surgery. VETERINARY ANAESTHESIA AND ANALGESIA, 35(3), 208-219. Author URL.
Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, Henley W, Ferrucci L, Bandinelli S, Corsi A-M, et al (2007). A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun, 8(7), 552-559. Abstract. Author URL.
Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, Bandinelli S, Corsi A-M, Ferrucci L, Guralnik JM, et al (2007). An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol a Biol Sci Med Sci, 62(1), 73-78. Abstract. Author URL.
Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, et al (2007). Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun, 8(4), 344-351. Abstract. Author URL.
Johnson MS, Martin MWS, Henley W (2007). Results of pacemaker implantation in 104 dogs. JOURNAL OF SMALL ANIMAL PRACTICE, 48(1), 4-11. Author URL.
Henley WE, Rogers K, Harkins L, Wood JLN (2006). A comparison of survival models for assessing risk of racehorse fatality. Prev Vet Med, 74(1), 3-20. Abstract. Author URL.
Sparkes AH, Rogers K, Henley WE, Gunn-Moore DA, May JM, Gruffydd-Jones TJ, Bessant C (2006). A questionnaire-based study of gestation, parturition and neonatal mortality in pedigree breeding cats in the UK. J Feline Med Surg, 8(3), 145-157. Abstract. Author URL.
Scase TJ, Edwards D, Miller J, Henley W, Smith K, Blunden A, Murphy S (2006). Canine mast cell tumors: correlation of apoptosis and proliferation markers with prognosis. J Vet Intern Med, 20(1), 151-158. Abstract. Author URL.
Platt S, Freeman J, di Stefani A, Wieczorek L, Henley W (2006). Prevalence of unilateral and bilateral deafness in border collies and association with phenotype. J Vet Intern Med, 20(6), 1355-1362. Abstract. Author URL.
Deaton CM, Brown-Feltner H, Henley WE, Roberts CA, Lekeux P, Schroter RC, Marlin DJ (2006). The effect of inspired gas density on pulmonary artery transmural pressure and exercise induced pulmonary haemorrhage. Equine veterinary journal. Supplement(36), 490-494. Abstract.
Raisis AL, Blissitt KJ, Henley W, Rogers K, Adams V, Young LE (2005). The effects of halothane and isoflurane on cardiovascular function in laterally recumbent horses. Br J Anaesth, 95(3), 317-325. Abstract. Author URL.
Crouch CF, Daly J, Henley W, Hannant D, Wilkins J, Francis MJ (2005). The use of a systemic prime/mucosal boost strategy with an equine influenza ISCOM vaccine to induce protective immunity in horses. Veterinary Immunology and Immunopathology, 108(3-4), 345-355. Abstract.
Verheyen KLP, Henley WE, Price JS, Wood JLN (2005). Training-related factors associated with dorsometacarpal disease in young Thoroughbred racehorses in the UK. Equine Vet J, 37(5), 442-448. Abstract. Author URL.
Wood JLN, Lakhani KH, Henley WE (2004). An epidemiological approach to prevention and control of three common heritable diseases in canine pedigree breeds in the United Kingdom. Vet J, 168(1), 14-27. Abstract. Author URL.
Daly JM, Yates PJ, Newton JR, Park A, Henley W, Wood JLN, Davis-Poynter N, Mumford JA (2004). Evidence supporting the inclusion of strains from each of the two co-circulating lineages of H3N8 equine influenza virus in vaccines. Vaccine, 22(29-30), 4101-4109. Abstract. Author URL.
Johnson MS, Martin M, Edwards D, French A, Henley W (2004). Pulmonic stenosis in dogs: Balloon dilation improves clinical outcome. Journal of Veterinary Internal Medicine, 18(5), 656-662. Abstract.
Park AW, Wood JLN, Daly JM, Newton JR, Glass K, Henley W, Mumford JA, Grenfell BT (2004). The effects of strain heterology on the epidemiology of equine influenza in a vaccinated population. Proc Biol Sci, 271(1548), 1547-1555. Abstract. Author URL.
Edwards DS, Henley WE, Ely ER, Wood JLN (2004). Vaccination and ill-health in dogs: a lack of temporal association and evidence of equivalence. Vaccine, 22(25-26), 3270-3273. Abstract. Author URL.
Edwards DS, Henley WE, Harding EF, Dobson JM, Wood JLN (2003). Breed incidence of lymphoma in a UK population of insured dogs. Vet Comp Oncol, 1(4), 200-206. Abstract. Author URL.
Henley WE, Wood JLN (2003). One hundred and one Dalmatians - the importance of being 'Patch'?. Veterinary Journal, 166(2), 105-106.
Ghani AC, Henley WE, Donnelly CA, Mayer S, Anderson RM (2002). Response to comments on the comparison of the effectiveness of non-nucleoside reverse transcriptase inhibitor and protease inhibitor-containing regimens using observational databases [6]. AIDS, 16(2), 302-303.
Ghani AC, Henley WE, Donnelly CA, Mayer S, Anderson RM (2001). Comparison of the effectiveness of non-nucleoside reverse transcriptase inhibitor-containing and protease inhibitor-containing regimens using observational databases. AIDS, 15(9), 1133-1142. Abstract.
Henley WE, Hand DJ (1997). Construction of a k-nearest-neighbour credit-scoring system. IMA Journal of Management Mathematics, 8(4), 305-321. Abstract.
Hand DJ, Henley WE (1997). Statistical classification methods in consumer credit scoring: a review. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY, 160, 523-541. Author URL.
Henley WE, Hand DJ (1996). A k-nearest-neighbour classifier for assessing consumer credit risk. Journal of the Royal Statistical Society Series D: the Statistician, 45(1), 77-95. Abstract.
Hand DJ, Henley WE (1993). Can reject inference ever work?. IMA Journal of Management Mathematics, 5(1), 45-55. Abstract.
Conferences
Zirk-Sadowski J, Masoli JAH, delgado J, Strain W, Hamilton W, Henley W, Melzer D, Ble A (In Press). Risks of Longer Term Proton Pump Inhibitor Exposure in 228,752 Older Adults. International Congress of the European Union Geriatric Society. Abstract.
Masoli JAH, Correa Delgado J, Bowman K, Ble A, Han Y, Henley W, welsh S, kuchel G, ferrucci L, Melzer D, et al (In Press). Twenty Year Blood Pressure Trajectories in 46,634 Older Patients. International Congress of the European Union Geriatric Society. Abstract.
Sellers A, Allard J, Henley W, McLean B, Shankar R (2023). 10 years of findings evaluating response of People with Intellectual Disability to Anti-Seizure Medications & Treatments. Author URL.
Streeter AJ, Henley W (2023). Adjusting for unmeasured confounding bias in the statin treatment options during vaccination against flu (STOPFlu) study: an application of the prior event rate ratio pairwise method. Author URL.
Henley W, Streeter AJ (2023). Statins may modulate the effectiveness of the flu vaccine according to the type of respiratory outcome: Results from the statin treatment options during vaccination against influenza (STOPFlu) study. Author URL.
Streeter AJ, Walker SJ, Rodgers L, Shelley A, Wellaway I, Hamilton F, Hamilton W, Henley W (2022). Assessing the effect of statin use on influenza vaccine effectiveness: a prior event rate ratio analysis in primary care data. Author URL.
Price DB, Henley W, Carter V, Skinner D, Alexander L, Vella R, Papi A, Fabbri LM, Kerstjens HAM, Roche N, et al (2022). Predicting Pneumonia Events in COPD Patients Using Medical Records. B21. BASIC, CLINICAL, AND TRANSLATIONAL COPD STUDIES: THE ONGOING HUNT FOR UNDERLYING MECHANISMS AND THERAPEUTIC TARGETS.
Price D, Henley W, Carter V, Skinner D, Vella R, Papi A, Fabbri LM, Kerstjens HA, Roche N, Singh D, et al (2021). Late Breaking Abstract - Comparing pneumonia risk in COPD patients initiating Fixed Dose Combination (FDC) inhaler comprising extrafine beclometasone dipropionate versus fluticasone. Airway pharmacology and treatment.
Price D, Henley W, Carter V, Skinner D, Vella R, Papi A, Fabbri LM, Kerstjens HA, Roche N, Singh D, et al (2021). Late Breaking Abstract - Pneumonia risk in COPD patients initiating extrafine Fixed Dose Combination (FDC) with beclometasone dipropionate (ef-FDC-BDP) versus long-acting bronchodilators (LABD). Airway pharmacology and treatment.
Dennis JM, Donnelly LA, Henley WE, Jones AG, McGovern AP, Sattar N, Holman RR, Pearson ER, Hattersley AT, Shields BM, et al (2020). Development of a decision aid for primary care to predict the best glucose-lowering treatment after metformin for people with type 2 diabetes. Author URL.
Murray E, Valabhji J, Lavida A, Henley W, Daff K, Irwin J, Brownlee L, McGough B (2019). A National Digital Diabetes Prevention Programme: Feasible, acceptable and effective?. Author URL.
Dennis JM, Henley W, Jones A, McGovern A, Pearson E, Hattersley A, Shields B (2019). Precision medicine in type 2 diabetes: harnessing individual-level trial data alongside routine care records to identify predictors of response to SGLT2 inhibitors and DPP4 inhibitors. Author URL.
Dennis JM, Shields BM, Henley WE, Jones AG, Hattersley AT (2019). Using trial data to test the proposed 5 novel subgroups of diabetes from Ahlqvist et al. derived from cluster analysis: simple clinical measures markedly outperform the 5 subgroups to predict drug response and diabetes progression. Author URL.
Dennis JM, Henley WE, Weedon MN, Rodgers LR, Jones AG, Pearson ER, Hattersley AT, Shields BM (2018). Are the new drugs better? Changing UK prescribing of Type 2 diabetes medications and effects on HbA1c and weight, 2010 to 2016. Author URL.
Streeter AJ, Henley WE (2018). Evidence from a quasi-experimental study for the effectiveness of the influenza vaccination against myocardial infarction in UK adults aged at least 65 y. Author URL.
Masoli JAH, Zirk-Sadowski J, Strain WD, Hamilton W, Delgado J, Henley W, Melzer D, Ble A (2018). QUESTIONING THE SAFETY OF WIDESPREAD PPI PRESCRIBING IN OLDER ADULTS. Author URL.
Henley WE, Streeter AJ (2018). Real-world effectiveness of influenza vaccination in older adults in the UK from 1997-2012: a quasi-experimental cohort study. Author URL.
Williams AJ, Henley W, Frank J (2018). The results and challenges of using administrative health data within a natural experimental evaluation of the abolition of prescription fees in Scotland.
Dennis JM, Shields BM, Henley WE, Jones AG, Hattersley AT (2018). Trial data show the proposed 5 diabetes subgroups from cluster analysis do predict drug response and diabetes progression but simple clinical measures are stronger predictors. Author URL.
Dennis JM, Henley WE, Weedon MN, Lonergan M, Rodgers LR, Jones AG, Sattar NA, Holman RR, Pearson ER, Hattersley AT, et al (2017). A calculator to predict durability of HbA<sub>1c</sub> response with DPP4 inhibitors, sulfonylureas and thiazolidinediones: a MASTERMIND precision medicine study. Author URL.
Hunt HA, Hyde CJ (2017). An overview of systematic reviews summarising the accuracy of brief cognitive assessments for identifying dementia in primary care. Methods for Evaluating Medical Tests and Biomarkers. 19th - 20th Jul 2016. Abstract.
Dennis JM, Shields BM, Henley WE, Knight BA, McDonald TJ, Hill AV, Weedon MN, Rodgers LR, Hattersley AT, Jones AG, et al (2017). Clinical markers of insulin resistance predict reduced glycaemic response with DPP4-inhibitors: a MASTERMIND stratified medicine study. Author URL.
Dennis JM, Henley WE, Weedon M, Lonergan M, Jones AG, Sattar N, Holman RR, Pearson ER, Hattersley AT, Shields BM, et al (2017). Development of an online risk calculator to predict durability of good glycaemic control with sulfonylurea and thiazolidinedione therapy: a MASTERMIND stratified medicine study. Author URL.
Streeter AJ, Masoli JAH, Ble A, Melzer D, Henley WE (2017). Pneumococcal Vaccine Effectiveness and its Interaction with Age: a UK Population Based Study in Older Adults. Author URL.
Shields BM, Dennis J, Henley W, Weedon M, Lonergan M, Rodgers L, Jones A, Sattar N, Holman R, Pearson E, et al (2017). Predictors of response to SGLT2-inhibitors and DPP4-inhibitors. Author URL.
Shields B, Dennis J, Henley W, Weedon M, Lonergan M, Jones A, Sattar N, Holman R, Pearson E, Hattersley A, et al (2017). Predictors of response to SGLT2-inhibitors and DPP4-inhibitors: a MASTERMIND stratified medicine study. Author URL.
Allard J, Shankar R, Henley W, Brown A, McLean B, Jadev M, Parrett M, Laugharne R, Noble A, Ridsdale L, et al (2017). WHAT DRIVES ED ATTENDANCE IN PEOPLE WITH EPILEPSY. Author URL.
Shields BM, Dennis JM, Henley W, Weedon M, Lonergan M, Rodgers L, Jones AG, Holman RR, Pearson ER, Hattersley AT, et al (2016). Personalising therapy in type 2 diabetes: the effect of BMI and sex on glycaemic response and side effects to sulphonylureas and thiazolidinediones. Author URL.
Dennis JM, Henley WE, Weedon MN, Lonergan M, Rodgers LR, Jones AG, Holman RR, Pearson ER, Hattersley AT, Shields BM, et al (2016). Personalizing Therapy in Type 2 Diabetes: the Effect of BMI and Gender on Response and Side Effects to Sulfonylureas and Thiazolidinediones. Author URL.
Dennis JM, Hattersley AT, Henley WE, Jones AG, Pearson ER, Shields BM (2016). Stratification using gender and body mass index (BMI) can predict side-effect risk in people with Type 2 diabetes initiating thiazolidinediones but not sulphonylureas: a MASTERMIND study. Author URL.
Shields B, Dennis J, Rodgers L, Jones A, Lonergan M, Henley W, Holman R, Pearson E, Hattersley A (2016). Stratification using gender and body mass index (BMI) results in better glycaemic control for longer: a MASTERMIND study. Author URL.
Dennis JM, Hattersley AT, Weedon M, Angwin C, Rodgers L, Pearson ER, Henley WE, Shields BM (2015). Development of oedema is associated with an improved glycaemic response in patients initiating thiazolidinediones: a MASTERMIND study. Author URL.
Kuzma E, Littlejohns TJ, Soni M, Chaves PHM, Kestenbaum BR, Kuller LH, Lopez OL, Becker JT, Langa KM, Henley WE, et al (2015). O2‐03‐01: Vitamin D and decline in global cognition and memory in the cardiovascular health study.
Littlejohns TJ, Kos K, Henley WE, Annweiler C, Beauchet O, Chaves PHM, Lang IA, Kuller LH, Langa KM, Lopez OL, et al (2015). O2‐03‐02: Vitamin D and the risk of developing neuroimaging abnormalities.
Lourida I, Kuzma E, Henley WE, Thompson-Coon J, Dickens CM, Langa KM, Llewellyn DJ (2015). P1‐255: Lifestyle, treatment, and cognitive decline in elderly diabetics.
Shields BM, Lonergan M, Dennis J, Jones A, Rogers L, Weedon M, Donnelly L, Holman R, Henley W, Pearson E, et al (2015). Patient characteristics are associated with treatment response to second line glucose lowering therapy: a MASTERMIND study. Author URL.
Dennis JM, Hattersley AT, Weedon M, Angwin CD, Rodgers L, Pearson ER, Henley WE, Shields BM (2015). Patients who develop oedema on initiating thiazolidinedione therapy have an improved glycaemic response: a MASTERMIND study. Author URL.
Jones AG, Lonergan M, Rodgers LR, Henley WE, Pearson EW, Hattersley AT, Shields BM (2015). Studies of diabetes treatment stratification should correct for baseline HbA1c: a MASTERMIND study. Author URL.
Masoli J, Winder R, Tavakoly B, Henley W, Ble A, Richards S, Melzer D (2014). OVERDIAGNOSING AND MISSING THE POINT?. Author URL.
Ble A, Masoli JAH, Barry HE, Winder RE, Tavakoly B, Henley WE, Valderas J, Melzer D, Richards SH (2014). P429: Potentially harmful prescribing in older UK Patients: What drugs matter?.
Llewellyn D, Lang I, Langa K, Henley W (2013). O2–13–02: Assessing long‐term postoperative cognitive decline using conventional and quasi‐experimental approaches: a Monte Carlo simulation study.
Littlejohns T, Soni M, Annweiler C, Chaves P, Fried L, Kestenbaum B, Lang I, Langa K, Lopez O, Kos K, et al (2013). P4–394: Vitamin D and incident Alzheimer's disease in the Cardiovascular Health Cognition Study.
Hunter J, Madden R, Stone A, Osborne N, Wheeler B, Barlow M, Bendall R, Lin N, Henley W, Gaze W, et al (2012). HEPATITIS E (HEV) IN SOUTH WEST ENGLAND. GEOGRAPHICAL, ENVIRONMENTAL AND SOCIAL FACTORS: a CASE CONTROL STUDY. Author URL.
Madden RG, Harrison A, Scobie L, Crossan C, Hunter JG, Parry R, Johnston P, Stratton J, Dickinson S, Bendall R, et al (2012). HEV IN RENAL TRANSPLANT AND HAEMODIALYSIS PATIENTS. Author URL.
Madden RG, Hunter JG, Stone AM, Thornton C, Barlow M, Lewis J, Bendall R, Lin N, Henley W, Dalton HR, et al (2012). LOCALLY ACQUIRED HEPATITIS E. GEOGRAPHICAL CLUSTERING AND ENVIRONMENTAL FACTORS: a NESTED CASE CONTROL STUDY. Author URL.
Llewellyn DJ, Kos K, Langa KM, Ferrucci L, Henley WE, Lang IA, Clarke R, Chiu H, Li J, Cherubini A, et al (2010). P4‐056: Association of Serum Leptin Levels with Cognitive Decline is Dependent on Body Mass Index.
