Disease, Diagnostics and Therapeutics
Module title | Disease, Diagnostics and Therapeutics |
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Module code | CSC2012 |
Academic year | 2020/1 |
Credits | 30 |
Module staff | Dr Alex Clarke (Lecturer) Dr Clare Gallon (Convenor) |
Duration: Term | 1 | 2 | 3 |
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Duration: Weeks | 11 | 11 | 1 |
Number students taking module (anticipated) | 172 |
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Module description
This module examines current knowledge of key pathophysiological mechanisms that underpin human disease, alongside key techniques used in the diagnosis, monitoring and treatment of disease. Small group learning and structured supporting sessions are used to provide scientific ‘trigger’ scenarios that introduce key transferable concepts within the setting of illustrative important diseases. In this module we support and encourage you to develop personal skills such as questioning, problem-solving, explaining and communication in addition to the development of your scientific knowledge.
Module aims - intentions of the module
This module promotes an integrated understanding of core human pathophysiological concepts and healthcare technologies and laboratory tests, using illustrative diseases. The module also explores key examples of where science has been translated successfully into clinical practice.
Intended Learning Outcomes (ILOs)
ILO: Module-specific skills
On successfully completing the module you will be able to...
- 1. Explain selected core integrated biomolecular and biomedical science principles underpinning human health and illustrative diseases.
- 2. Outline the key scientific principles underpinning the prevention, diagnosis and management of important diseases..
- 3. Identify the key principles and challenges for healthcare planning and delivery, including the development and implementation of new health technologies.
ILO: Discipline-specific skills
On successfully completing the module you will be able to...
- 4. Explain key concepts of physiological and pathophysiological processes in health and disease
- 5. With limited guidance, apply skills of critical thinking, problem-formulation and problem-solving to clinical science practice
ILO: Personal and key skills
On successfully completing the module you will be able to...
- 6. With limited guidance, apply skills of critical thinking, problem-formulation and problem-solving to clinical science practice.
- 7. With limited guidance, manage time, workload, ambiguity, change and stress effectively
- 8. Effectively communicate and discuss scientific principles, using visual aids where appropriate.
- 9. With limited guidance, demonstrate professional competence in communicating effectively with fellow scientists.
Syllabus plan
The module provides learning opportunities around key medical science concepts, using important human disease triggers. Teaching involves Structured Small Group Learning and structured workshops/tutorials, to demonstrate key scientific principles using physical and electronic resources. The scientific basis of associated healthcare technologies employed in the prevention, diagnosis and management of illustrative diseases will also be explored.
Whilst the module’s precise content may vary from year to year, a list of the main topics is as follows:
Autonomic nervous system
Somatic nervous system
Muscle contraction mechanism and signalling (smooth, cardiac, skeletal)
Second messenger signalling (e.g. HIF, NF-kappa B, tyrosine kinase receptors, Hedgehog signalling, PI3K/AKT, Wnt, GPCR)
Acid-base balance
Atherosclerosis
Lab techniques (PCR, WB, IHC, ELISA)
Sensitivity and specificity of diagnostic tests
Inherited heart disease
Action potentials
Bacterial infections
Immune response (activation and propagation)
Vaccines
Anti-Inflammatory medications
Cell cycle regulation and checkpoint control
Glucose handling in the body
Recombinant protein production
Hypothalamus-Pituitary-Thyroid axis
Renin-Angiotensin-Aldosterone system
Blood pressure regulation
Haemostasis
Skin disorders
Immune tolerance and autoimmunity
Layers of the skin
Protein degradation
Cell Death
Senescence
Nociception
Central nervous system neurotransmission (monoamine and amino acid)
Nervous system disorders and clinical intervention
Learning activities and teaching methods (given in hours of study time)
Scheduled Learning and Teaching Activities | Guided independent study | Placement / study abroad |
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59.5 | 240.5 | 0 |
Details of learning activities and teaching methods
Category | Hours of study time | Description |
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Scheduled Learning and Teaching Activities | 35 | Expert-facilitated, small group learning sessions delivered synchronously using online video conferencing. |
Scheduled Learning and Teaching Activities | 4 | Optional e-resource coursework assessment troubleshooting drop-ins delivered synchronously using online video conferencing. |
Scheduled Learning and Teaching Activities | 7 | Revision and e-resource coursework workshops & module induction lecture delivered as short pre-recorded videos and supported by asynchronous Q&A by discussion board. |
Scheduled Learning and Teaching Activities | 6 | Disease specific workshops delivered as short pre-recorded videos and supported by asynchronous Q&A by discussion board. |
Scheduled Learning and Teaching Activities | 7.5 | Active application workshops delivered as online worksheets , supported by short asynchronous videos and asynchronous Q&A on discussion forum. |
Guided independent study | 20 | Watching asynchronous module specific web-based video recordings supported by online quizzes as preparation for small group learning. |
Guided independent study | 220.5 | Session preparation, self-directed learning using on-line resources, e-resource creation & peer marking, revision |
Formative assessment
Form of assessment | Size of the assessment (eg length / duration) | ILOs assessed | Feedback method |
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Online MCQ Knowledge Tests | 160 questions | 1-2,6-7 | Online |
E-resourse assessment | 1 group submission (max 6 PowerPoint slides each) | 1-5, 7 | Written (Tutor) |
Example SAQ | 2 questions | 1-5, 8, 9 | Online |
Summative assessment (% of credit)
Coursework | Written exams | Practical exams |
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45 | 55 | 0 |
Details of summative assessment
Form of assessment | % of credit | Size of the assessment (eg length / duration) | ILOs assessed | Feedback method |
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SAQ Examination | 55 | 3 hour | 1-8 | Written |
e-resourses | 35 | 2 x submissions (max. 6 PowerPoint slides equivalent each). Peer marking engagement with 4 individual e-resources (individual activity) (2 feedback comments per e-resource) submitted on time | 1-9 | Written (Tutor & Peer) |
e-resource and concept map portfolio | 10 | 2 x group submissions (1 portfolio per term comprising a group concept map and associated e-resources for each of 5 triggers per term). Group peer marking of 2 group portfolios (minimum 2 feedback comments per portfolio) | 1-9 | Written (Peer Group) |
Details of re-assessment (where required by referral or deferral)
Original form of assessment | Form of re-assessment | ILOs re-assessed | Timescale for re-assessment |
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SAQ Examination | SAQ Examination 3 hours. See note below. | 1-8 | Referral/deferral period |
e-resources | e-resource(s) (max. 6 PowerPoint slides equivalent each). | 1-9 | Referral/deferral period |
e-resource and concept map portfolio | Individual assessment of 1 group portfolio | 1-9 | Referral/deferral period |
Re-assessment notes
Please also refer to the TQA section on general Referral/Deferral guidelines: http://as.exeter.ac.uk/academic-policy-standards/tqa-manual/aph/consequenceoffailure/
If you have been referred in the module because of the failure in the in-course e-resource, you will need to re-submit the e-resource element(s) that achieved less than 40% on first submission, during the referral/deferral period.
Indicative learning resources - Basic reading
The recommended texts, e-resources and other supporting resources for the module are posted on electronic learning environment
Indicative learning resources - Web based and electronic resources
https://vle.exeter.ac.uk/course/view.php?id=9083
Indicative learning resources - Other resources
An up to date reading list of specific texts will be provided on the module web page.
Credit value | 30 |
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Module ECTS | 15 |
Module pre-requisites | CSC1005 Integrated Human Physiology |
Module co-requisites | None |
NQF level (module) | 5 |
Available as distance learning? | No |
Origin date | 24/05/2016 |
Last revision date | 11/08/2020 |