Cancer diagnosis and detection

The Cancer Theme portfolio builds on more than two decades of internationally recognized and impactful research. It conducts qualitative, quantitative and mixed methods research primarily related to the diagnosis and detection of symptomatic cancer through primary and community care. Initially this was identifying who should be tested for possible cancer and was followed by studying how and where testing should be conducted. Our focus now extends to studying:

cancer screening;
the added value of genetic information; and
the use of new technologies to screen higher-risk patients and asymptomatic populations.

The Cancer Theme’s vision is to inform (inter)national policy and clinical practice through impactful research to improve early cancer diagnosis and patient outcomes through the study of asymptomatic and symptomatic populations and incorporating genetic data.

We are a multidisciplinary team of clinicians and researchers with backgrounds in statistics, health services and public health research, allied health care professions, general practice, psychology and biological/biomedical sciences. We attract a wide portfolio of funders, including NIHR, cancer charities, philanthropy and industrial partners.

The aims are:

To conduct research to identify how best to reduce inequalities in testing for suspected cancer in symptomatic patients presenting to primary care
To conduct research to identify how best to screen for cancer in higher-risk patients and asymptomatic populations
To investigate the value of adding genetic information to symptom information to facilitate the early diagnosis of cancer

Theme Leadership

Professor Richard Neal - Co-Lead

Dr Sarah Price - Co-Lead

Projects

Flagship projects

Title	Funder	Amount £	Project/ Programme/ Fellowship	Exeter lead investigator
NHS-Galleri A randomised, controlled trial to assess the clinical utility of a multi-cancer early detection (MCED) test for population screening in the United Kingdom (UK) when added to standard of care	GRAIL Bio UK Ltd.		Clinical Trial	Richard Neal
ERICA Electronic Risk Assessment for Cancer	Gillings Family Foundation	£2,000,000	Project	Willie Hamilton
CD3: Cancer Data Driven Detection	The Cancer Data Driven Detection programme is jointly supported by CRUK, NIHR, EPSRC, HDR UK & ADR UK	£10 million	Programme	Gary Abel
SPOCC The SPOtting Cancer among Comorbidities programme. Supporting clinical decision making in patients with symptoms of cancer and pre-existing conditions.	NIHR	£1,435,226	Programme Grant	Gary Abel
CanTest The CanTest Collaborative: Cancer Testing at the Right place, right time, by your family doctor	CRUK	£2 million	Catalyst Award	Willie Hamilton
Cancer Learn Understanding inequalities in cancer diagnostic outcomes for people with learning disabilities	NIHR	£1,190,144	Programme Grant	Luke Mounce

Other current active projects

Other current active projects

Title	Funder	Amount £	Project/ Programme/ Fellowship	Exeter lead investigator
The MODE Study: Non-cancer diagnoses and their potential for missed opportunities in symptomatic cancer diagnosis: a mixed methods study	NIHR	£537,123	Project	Sarah Price, Richard Neal
AI intelligent triage for lower gastrointestinal tumours across West Yorkshire	Innovate UK	£984,838	Project	Richard Neal
MEDLEY Methods of Early Detection of Lung CancEr in PrimarY Care	NIHR Health Technology Assessment	£1,237,085	Project	Richard Neal
ThinkCancer!: A pragmatic randomised controlled phase III trial of a novel behavioural intervention for primary care teams to promote earlier cancer diagnosis with embedded process and economic evaluation	Cancer Research UK	£1.3 million	Trial	Richard Neal
CANDETECT: Accelerating detection of upper gastro-intestinal (UGI) cancers using a multi-cancer early detection platform in primary care	Cancer Research UK	£2.59 million	Early Detection and Diagnosis Programme Grant.	Richard Neal
The Yorkshire Lung Screening Trial	Yorkshire Cancer Research	£9.6 million	Trial	Richard Neal
Saving Lives - Improving the Early Diagnosis of Cancer using Platelet Count	Philanthropic funding	£411,111		Sarah Bailey

Other recently completed projects

Other recently completed projects

	End date	Funder	Amount £	Project/ Programme/ Fellowship	Exeter lead investigator
COLOFIT Optimal use of Faecal Immunochemical Testing for patients with symptoms of possible colorectal cancer	October 2024	NIHR	£757,064	Health Technology Assessment	Willie Hamilton
OSCA A mixed-methods study of attendance for suspected cancer investigations in people with anxiety and/or depression	September 2024	NIHR School for Primary Care Research	£98,500	Project	Sarah Price & Luke Mounce
Understanding and identifying ways to optimise cancer recognition, referral, and management for people with dementia in primary and community care: a qualitative interview study	2024	Research for Patient Benefit, NIHR	£153,000	Project	Richard Neal
Can community pharmacy improve early cancer detection in deprived areas? Systematic review update and survey of community pharmacy staff	2024	NIHR School for Primary Care Research	£97,000	Project	Judit Konya, Richard Neal
Improving the NHS Urgent Referral Pathways for Cancer using an Affordable Blood Test for Cancer.	2022	Small Business Research Initiative	£902,000	Project	Richard Neal
Evaluation of biomarkers and imaging for the detection of intra-thoracic cancers - systematic reviews to inform the development of an accelerated platform for early diagnosis in primary care	2023	NIHR School for Primary Care Research	£120,000	Primer Award	Richard Neal
Development of a myeloma case-finding approach for higher-risk patients: analysis of routine blood tests.	2022	Cancer Research UK	£77,000	Primer Award	Richard Neal
YKST Yorkshire Kidney Screening Trial – a Yorkshire Lung Screening Trial sub-study.	2023	Yorkshire Cancer Research	£600,000	Trial	Richard Neal
iDxLung - integrating non-invasive diagnostics into NHSE Lung Health Checks in Wessex and Yorkshire	2023	Innovate UK	£1 million		Richard Neal
Lung Cancer Diagnosis Measurement Instrument	2021	Gordon & Betty Moore Foundation (US)	$500,000		Richard Neal
A Machine Learning/AI Cancer Rule-Out Test for the NHS Two Week Wait Pathway (Pinpoint Data Analytics).		MRC/ LEP Procurement Innovate UK	£123,000 £344,000		Richard Neal
PRU2 Policy Research Unit in Cancer Awareness, Screening and Early Diagnosis, Department of Health & Social Care	2023	Department of Health and Social Care	£5 million		Willie Hamilton Richard Neal
The effect of adding a personalised smoking cessation intervention to a lung cancer screening programme.	2022	Yorkshire Cancer Research	£913,000		Richard Neal
Developing and feasibility testing an Acceptance and Commitment Therapy (ACT) intervention for improving medication-taking behaviour in women with early stage invasive breast cancer - the ACTION trial	2021	Yorkshire Cancer Research	£375,000		Richard Neal

Publications

Flagship publications

1.	Neal RD, Johnson P, Clarke CA, Hamilton SA, Zhang N, Kumar H, Swanton C, Sasieni P. Cell-free DNA based multi-cancer early detection test in an asymptomatic screening population (NHS-Galleri): design of a pragmatic, prospective, randomised, controlled trial. Cancers 2022;14(19):4818 doi: 10.3390/cancers14194818
2.	Neal RD et al. Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Br J Cancer 2015; 112:S92-S107 https://doi.org/10.1038/bjc.2015.48
3.	Merriel SWD, Akter N, Zakkak N, Swann R, McPhail S, Rubin G, Lyratzopoulos G, Abel G. Factors affecting prostate cancer detection through asymptomatic prostate-specific antigen testing in primary care in England: evidence from the 2018 National Cancer Diagnosis Audit. Br J Gen Pract 2025 https://bjgp.org/content/early/2025/02/24/BJGP.2024.0376
4.	Mounce LTA, Calitri R, Hamilton W, Rafiq M, Emery JD, Giannakeas V, Kotsopoulos J, Bailey SER. Improving the clinical utility of platelet count for cancer detection in primary care: a cohort study in England, Canada and Australia. Cancers; 2024, 16(17): 3074 https://www.mdpi.com/2072-6694/16/17/3074
5.	Down L, Barlow M, Bailey SER, Mounce LTA, Merriel SWD, Watson J, Martins T. Association between patient ethnicity and prostate cancer diagnosis following a prostate-specific antigen test: a cohort study of 730,000 men in primary care in the UK. BMC Medicine 2024, 22 https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03283-5
6.	Green H, Merriel SWD, Oram RA, Ruth KS, Tyrrell J, Jones SE, Thirlwell C, Weedon MN, Bailey SER. Applying a genetic risk score for prostate cancer to men with lower urinary tract symptoms in primary care to predict prostate cancer diagnosis: a cohort study in the UK Biobank. Br J Cancer 2022 https://www.nature.com/articles/s41416-022-01918-z
7.	Bailey SER, Abel GA, Atkins A, Byford R, Davies S-J, Mays J, McDonald TL, Miller J, Neck C, Renninson J, Thomas P, Walter FM, Warren S, Hamilton W. Diagnostic performance of a faecal immunochemical test for patients with low-risk symptoms of colorectal cancer in primary care: an evaluation in the South West of England. Br J Cancer 2021; 124:1231-1236 https://www.nature.com/articles/s41416-020-01221-9
8.	Martins T, Abel G, Ukoumunne OC, Mounce LTA, Price S, Lyratzopoulos, Chinegwundoh F, Hamilton W. Ethnic inequalities in routes to diagnosis of cancer: a population-based UK cohort study. Br J Cancer 2022; 127:863-871 https://www.nature.com/articles/s41416-022-01847-x
9.	Stewart GD, Godoy A, Farquhar F, Kitt J, Cartledge J, Kimuli M, Shinkins B, Burbidge S, Burge SW, Caglic I, Collins E, Crosbie PAJ, Eckert C, Fraser S, Hancock N, Iball GR, Marshall C, Masson G, Neal RD, Rogerson S, Rossi SH, Smith A, Sharp SJ, Simmonds I, Wallace T, Ward M, Callister MEJ, Usher-Smith JA. Abdominal non-contrast computed tomography scanning to screen for kidney cancer and other abdominal pathology within community-based computed tomography screening for lung cancer: results of the Yorkshire Kidney Screening Trial. European Urology in press
10.	Crosbie PAJ, Gabe R, Simmonds I, Hancock N, Alexandris P, Kennedy M, Rogerson S, Baldwin D, Booton R, Bradley C, Darby M, Franks K, Lindop J, Janes SM, Møller H, Murray RL, Neal RD, Quaife SL, Upperton S, Shinkins B, Tharmanathan P, Callister MEJ. Participation in community-based lung cancer screening: the Yorkshire Lung Screening Trial (YLST). European Respiratory Journal 2022 doi: 10.1183/13993003.00483-2022

Recent publications

Recent publications

Friedrich B, Renzi C, Mitchinson L et al. Symptom Attribution, Help Seeking and Willingness to Undergo Diagnostic Investigations for Bowel Cancer Symptoms in People With Anxiety and/or Depression-A Vignette Study. Psychooncology. 2025;34(4):e70151.
Ayaz-Shah AA, Neal RD, Lloyd KE et al. GPs' acceptability and feasibility for using point-of-care tests for cancer in primary care: a qualitative interview study. BJGP Open. 2025:BJGPO.2024.0191.
Ricciardi GE, Pennisi F, Von Wagner C et al. Attribution of colorectal cancer symptoms to medications for pre-existing chronic conditions: a secondary analysis of a vignette study in England. J Public Health (Oxf). 2025:fdaf014.
Abel GA, Hays RD, Campbell JL, Elliott MN. The Use of External Anchors When Examining Differences in Scale Performance in Patient Experience Surveys. Med Care. 2025;63(4):311-316.
Sexton V, Grimley C, Dale J et al. Safety and accuracy of digitally supported primary and secondary urgent care telephone triage in England: an observational study using routine data. BMC Med Inform Decis Mak. 2025;25(1):52.
Almatrafi A, Gabe R, Beeken RJ et al. Impact of frailty and comorbidity on initial response to lung cancer screening invitation and low-dose CT screening uptake: Findings from the Yorkshire Lung Screening Trial. J Med Screen. 2025:9691413251315087.
Swanton C, Bachtiar V, Mathews C et al. NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants. Clin Trials. 2025;22(2):227-238.
Dobson C, Biran A, Rees C et al. Practitioner perspectives on symptomatic faecal immunochemical testing: a qualitative interview study. Br J Gen Pract. 2025:BJGP.2024.0358.
Rafiq M, White B, Barclay M et al. A UK population-based case-control study of blood tests before cancer diagnosis in patients with non-specific abdominal symptoms. Br J Cancer. 2025;132(5):450-461.
Crooks CJ, West J, Jones J et al. COLOFIT: Development and Internal-External Validation of Models Using Age, Sex, Faecal Immunochemical and Blood Tests to Optimise Diagnosis of Colorectal Cancer in Symptomatic Patients. Aliment Pharmacol Ther. 2025;61(5):852-864.
Bradley SH, Neal RD, Callister ME et al. General practice chest X-ray rate is associated with earlier lung cancer diagnosis and reduced all-cause mortality: a retrospective observational study. Br J Gen Pract. 2025:BJGP.2024.0466.
Bradley SH, Baldwin D, Bhartia BSK et al. Achieving earlier diagnosis of symptomatic lung cancer. Br J Gen Pract. 2024;75(750):40-43.
Gabe R, Crosbie PAJ, Vulkan D et al. Prospective Evaluation of Lung Cancer Screening Eligibility Criteria and Lung Cancer Detection in the Yorkshire Lung Screening Trial. J Thorac Oncol. 2025;20(4):425-436.
Harnan S, Hamilton J, Simpson E et al. Faecal immunochemical tests for patients with symptoms suggestive of colorectal cancer: An updated systematic review and multiple-threshold meta-analysis of diagnostic test accuracy studies. Colorectal Dis. 2024;27(1):e17255.
Martins T, Down L, Samuels A et al. Understanding ethnic inequalities in cancer diagnostic intervals: a cohort study of patients presenting suspected cancer symptoms to GPs in England. Br J Gen Pract. 2025:BJGP.2024.0518.
Pennisi F, Ricciardi GE, von Wagner C et al. Impact of Self-Reported Long-Term Mental Health Morbidity on Help-Seeking and Diagnostic Testing for Bowel-Related Cancer Symptoms: A Vignette Study. Cancer Med. 2024;13(23):e70426.
Sussex J, Atherton H, Abel G et al. Supporting Patients' Use of Digital Services in Primary Health Care in England: Synthesis of Evidence From a Mixed Methods Study of "Digital Facilitation". JMIR Hum Factors. 2024;11:e52516.
Fletcher E, Campbell JL, Pitchforth E et al. Association between cancer risk assessment tool use and GP consultation duration: an observational study. Br J Gen Pract. 2025:BJGP.2024.0135.
Burns A, Fletcher E, Shephard E et al. Clinical decision making and risk appraisal using electronic risk assessment tools (eRATs) for cancer diagnosis: A qualitative study of GP experiences. BJGP Open. 2024:BJGPO.2024.0243.
Streeter AJ, Rodgers LR, Masoli J et al. Correction: Real-world effectiveness of pneumococcal vaccination in older adults: Cohort study using the UK Clinical Practice Research Datalink. PLoS One. 2024;19(11):e0314373.
Sasieni P, Smittenaar R, Hubbell E et al. Correction: Modelled mortality benefits of multi-cancer early detection screening in England. Br J Cancer. 2024;131(12):1942-1944.
Rees C, Hamilton W. Bowel cancer prevention: are we missing an opportunity?. Lancet Gastroenterol Hepatol. 2024;9(12):1080.
Moore S, Price S, Dongo G et al. Clinical risk factors for pancreatic cancer: protocol for an umbrella review. BMJ Open. 2024;14(11):e089008.
Akter N, Lyratzopoulos G, Swann R et al. Variation in the use of primary care-led investigations prior to a cancer diagnosis: analysis of the National Cancer Diagnosis Audit. BMJ Qual Saf. 2024:bmjqs-2024-017264.
Abel GA, Agniel D, Elliott MN. The good, the bad and the ugly: What do we really do when we identify the best and the worst organisations?. BMJ Qual Saf. 2024;34(1):53-61.
Nicholson BD, Virdee P, Aveyard P et al. Prioritising primary care patients with unexpected weight loss for cancer investigation: diagnostic accuracy study (update). BMJ. 2024;387:e080199.
Hamad W, Grigore B, Walford H et al. Biomarkers Suitable for Early Detection of Intrathoracic Cancers in Primary Care: A Systematic Review. Cancer Epidemiol Biomarkers Prev. 2025;34(1):19-34.
Merriel SW, Akter N, Zakkak N et al. Factors affecting prostate cancer detection through asymptomatic prostate-specific antigen testing in primary care in England: evidence from the 2018 National Cancer Diagnosis Audit. Br J Gen Pract. 2025:BJGP.2024.0376.
Mizel ML, Haas A, Adams JL et al. County-level racial bias is associated with worse care for white and especially black older US adults: a cross-sectional observational study. BMJ Qual Saf. 2024:bmjqs-2024-017430.
Nankervis H, Huntley AL, Whiting P et al. Communicating blood test results in primary care: a mixed-methods systematic review. Br J Gen Pract. 2025;75(753):e222-e231.
Sundar S, Agarwal R, Davenport C et al. Risk-prediction models in postmenopausal patients with symptoms of suspected ovarian cancer in the UK (ROCkeTS): a multicentre, prospective diagnostic accuracy study. Lancet Oncol. 2024;25(10):1371-1386.
Merriel SWD, Buttle P, Price SJ et al. Early economic evaluation of magnetic resonance imaging for prostate cancer detection in primary care. BJUI Compass. 2024;5(9):855-864.
Abel G, Atherton H, Sussex J et al. Current experience and future potential of facilitating access to digital NHS primary care services in England: the Di-Facto mixed-methods study. Health Soc Care Deliv Res. 2024;12(32):1-197.
Papoutsi C, Abel G, Iglesias C et al. Evaluating video and hybrid group consultations in general practice: mixed-methods, participatory study protocol (TOGETHER 2). NIHR Open Res. 2024;4:30.
Mounce LTA, Calitri R, Hamilton W et al. Improving the Clinical Utility of Platelet Count for Cancer Detection in Primary Care: A Cohort Study in England, Canada, and Australia. Cancers (Basel). 2024;16(17):3074.
Stewart GD, Godoy A, Farquhar F et al. Abdominal Noncontrast Computed Tomography Scanning to Screen for Kidney Cancer and Other Abdominal Pathology Within Community-based Computed Tomography Screening for Lung Cancer: Results of the Yorkshire Kidney Screening Trial. Eur Urol. 2024:S0302-2838(24)02567-3.
Barlow M, Down L, Mounce LTA et al. The diagnostic performance of CA-125 for the detection of ovarian cancer in women from different ethnic groups: a cohort study of English primary care data. J Ovarian Res. 2024;17(1):173.
Mitchinson L, von Wagner C, Blyth A et al. Clinical decision-making on lung cancer investigations in primary care: a vignette study. BMJ Open. 2024;14(8):e082495.
Winder R, Campbell JL, Akter N et al. Exploring How Patients Are Supported to Use Online Services in Primary Care in England Through "Digital Facilitation": Survey Study. J Med Internet Res. 2024;26:e56528.
Mallabar-Rimmer B, Merriel SWD, Webster AP et al. Colorectal cancer risk stratification using a polygenic risk score in symptomatic primary care patients-a UK Biobank retrospective cohort study. Eur J Hum Genet. 2024;32(11):1456-1464.
Save T, Neal RD, Round T. A multi-cancer early detection (MCED) test: clinical update for GPs. Br J Gen Pract. 2024;74(745):380-382.
Moore SF, Abel GA, Mounce LT. Challenges of diagnosing rare cancers in primary care. Br J Gen Pract. 2024;74(745):340-341.
Sullivan SA, Morris R, Kounali D et al. External validation of a prognostic model to improve prediction of psychosis: a retrospective cohort study in primary care. Br J Gen Pract. 2024;74(749):e854-e860.
Atherton H, Eccles A, Poltawski L et al. Investigating Patient Use and Experience of Online Appointment Booking in Primary Care: Mixed Methods Study. J Med Internet Res. 2024;26:e51931.
Price S, Bailey S, Hamilton W et al. The effects of the first UK lockdown for the COVID-19 pandemic on primary-care-recorded cancer and type-2 diabetes mellitus records: A population-based quasi-experimental time series study. Cancer Epidemiol. 2024;91:102605.
Parsons J, Abel G, Bryce C et al. Supporting patients with a mental health diagnosis to use online services in primary care. A qualitative interview study. Digit Health. 2024;10:20552076241255637.
Hiscock J, Law RJ, Brain K et al. Hidden systems in primary care cancer detection: an embedded qualitative intervention development study. Br J Gen Pract. 2024;74(745):e544-e551.
Masud N, Hamilton W, Tarasenko Y. Prevalence of Cigarette Smoking, E-cigarette Use, and Dual Use Among Urban and Rural Women During the Peripartum Period, PRAMS 2015-2020. Public Health Rep. 2024;139(6):708-716.
Graham CD, Ellison R, Hall LH et al. A pilot randomised controlled trial of acceptance and commitment therapy for medication decision-making and quality of life in women with breast cancer: The ACTION trial. Psychooncology. 2024;33(5):e6349.
Bradley SH, Jones D, Wood S et al. Diagnosing cancer in English community pharmacies. BMJ. 2024;385:e077087.
Kapadia P, Zimolzak AJ, Upadhyay DK et al. Development and Implementation of a Digital Quality Measure of Emergency Cancer Diagnosis. J Clin Oncol. 2024;42(21):2506-2515.
Chen G, Barlow M, Down L et al. Exploring ethnic differences in the distribution of blood test results in healthy adult populations to inform earlier cancer detection: a systematic review. Fam Pract. 2024;41(5):638-648.
Ortiz AP, Hospedales CJ, Méndez-Lázaro PA et al. Protecting Caribbean patients diagnosed with cancer from compounding disasters. Lancet Oncol. 2024;25(5):e217-e224.
di Martino E, Honey S, Bradley SH et al. Understanding GPs' referral decisions for younger patients with symptoms of cancer: a qualitative interview study. Br J Gen Pract. 2024;74(743):e387-e392.
Murray RL, Alexandris P, Baldwin D et al. Uptake and 4-week quit rates from an opt-out co-located smoking cessation service delivered alongside community-based low-dose computed tomography screening within the Yorkshire Lung Screening Trial. Eur Respir J. 2024;63(4):2301768.
Bradley SH, Shinkins B, Abel G, Callister MEJ. Interpreting diagnostic accuracy studies based on retrospective routinely collected data. J Clin Epidemiol. 2024;170:111359.
Merriel SW, Archer S, Forster AS et al. Acceptability of magnetic resonance imaging for prostate cancer diagnosis with patients and GPs: a qualitative interview study. Br J Gen Pract. 2024;74(745):e527-e533.
Barlow M, Hamilton W, Bailey SER. The Clinical Value of Pre-Diagnostic Thrombocytosis for the Detection of Lung Cancer in Primary Care. Cancers (Basel). 2024;16(6):1154.
Campbell J, Atherton H, Abel G, Sussex J. Digital facilitation: supporting the use of NHS digital and online services. Br J Gen Pract. 2024;74(741):150-151.
Down L, Barlow M, Bailey SER et al. Association between patient ethnicity and prostate cancer diagnosis following a prostate-specific antigen test: a cohort study of 730,000 men in primary care in the UK. BMC Med. 2024;22(1):82.
Watson J, Hamilton W, Salisbury C, Banks J. Doctor-patient communication about blood tests: Qualitative interview study in general practice. Ann Fam Med. 2022;20(Suppl 1):2858.
Hamilton W. Leukaemia diagnosis and primary care. Br J Gen Pract. 2024;74(739):54-55.
Khan AZ, Lavu D, Knowles L, Neal RD. Pain syndromes in Parkinson's disease: an update for general practice. Br J Gen Pract. 2024;74(739):90-92.
Abel G, Froud R, Pitchforth E et al. Informing the development of a scoring system for National Health Service Clinical Impact Awards; a Delphi process and simulated scoring exercise. JRSM Open. 2024;15(1):20542704231217887.
Cocco P, Smith AF, Neal RD, Shinkins B. The National Health Service urgent cancer referral pathway for suspected urological cancers: early economic evaluation of a risk prediction test. Int J Technol Assess Health Care. 2024;40(1):e9.
Khan N, Pitchforth E, Winder R et al. What helps patients access web-based services in primary care? Free-text analysis of patient responses to the Di-Facto questionnaire. BMC Prim Care. 2024;25(1):20.
Khan AZ, Lavu D, Neal RD. Parkinson's disease: a scoping review of the quantitative and qualitative evidence of its diagnostic accuracy in primary care. Br J Gen Pract. 2024;74(741):e227-e232.
Little P, Bradbury K, Stuart B et al. Digital intervention (Renewed) to support symptom management, wellbeing, and quality of life among cancer survivors in primary care: a randomised controlled trial. Br J Gen Pract. 2025:BJGP.2023.0262.
Willis TA, Neal RD, Walter FM, Foy R. Priorities for implementation research on diagnosing cancer in primary care: a consensus process. BMC Health Serv Res. 2023;23(1):1308.
Hamilton W, Bailey SER. Colorectal cancer in symptomatic patients: How to improve the diagnostic pathway. Best Pract Res Clin Gastroenterol. 2023;66:101842.
Hampton JS, Kenny RPW, Rees CJ et al. The performance of FIT-based and other risk prediction models for colorectal neoplasia in symptomatic patients: a systematic review. EClinicalMedicine. 2023;64:102204.
Logan RPH, Hamilton W. Editorial: Less is more for colorectal cancer diagnosis - FIT leads the way. Aliment Pharmacol Ther. 2023;58(7):725-726.
O'Dowd EL, Merriel SWD, Cheng VWT et al. Clinical trials in cancer screening, prevention and early diagnosis (SPED): a systematic mapping review. BMC Cancer. 2023;23(1):820.
Hamilton W, Price S. Targeting diagnostic interventions for oesophageal cancer. Lancet Reg Health Eur. 2023;32:100716.
Koo MM, Mounce LTA, Rafiq M et al. Guideline concordance for timely chest imaging after new presentations of dyspnoea or haemoptysis in primary care: a retrospective cohort study. Thorax. 2024;79(3):236-244.
Bradley C, Alexandris P, Baldwin DR et al. Measuring spirometry in a lung cancer screening cohort highlights possible underdiagnosis and misdiagnosis of COPD. ERJ Open Res. 2023;9(4):00203-2023.
Moore SF, Price SJ, Bostock J et al. Incidence of 'Low-Risk but Not No-Risk' Features of Cancer Prior to High-Risk Feature Occurrence: An Observational Cohort Study in Primary Care. Cancers (Basel). 2023;15(15):3936.
Cranfield BM, Abel GA, Swann R et al. Pre-Referral Primary Care Blood Tests and Symptom Presentation before Cancer Diagnosis: National Cancer Diagnosis Audit Data. Cancers (Basel). 2023;15(14):3587.
Hamilton W, Turabi N, Harrison S. Cancer care has not caused waiting lists to mushroom. BMJ. 2023;382:1692.
Bowcock S, Atkin C, Iqbal G et al. Presenting Symptoms in Newly Diagnosed Myeloma, Relation to Organ Damage, and Implications for Symptom-Directed Screening: A Secondary Analysis from the Tackling Early Morbidity and Mortality in Myeloma (TEAMM) Trial. Cancers (Basel). 2023;15(13):3337.
Edwards L, Pickett J, Ashcroft DM et al. UK research data resources based on primary care electronic health records: review and summary for potential users. BJGP Open. 2023;7(3):BJGPO.2023.0057.
Nankervis H, Huntley A, Whiting P et al. Blood test result communication in primary care: mixed-methods systematic review protocol. BJGP Open. 2023;7(4):BJGPO.2023.0105.
Martins T, Ukoumunne OC, Lyratzopoulos G et al. Are There Ethnic Differences in Recorded Features among Patients Subsequently Diagnosed with Cancer? An English Longitudinal Data-Linked Study. Cancers (Basel). 2023;15(12):3100.
Jones D, Ali OM, Honey S et al. Patients' views on the decision to investigate cancer symptoms in older adults: a qualitative interview study in primary care. Br J Gen Pract. 2023;73(733):e597-e604.
Snudden CM, Calanzani N, Archer S et al. Can we do better? A qualitative study in the East of England investigating patient experience and acceptability of using the faecal immunochemical test in primary care. BMJ Open. 2023;13(6):e072359.
Treadgold BM, Campbell JL, Abel GA et al. Investigating Clinical Excellence and Impact Awards (INCEA): a qualitative study into how current assessors and other key stakeholders define and score excellence. BMJ Open. 2023;13(6):e068602.
Swann R, McPhail S, Abel GA et al. National Cancer Diagnosis Audits for England 2018 versus 2014: a comparative analysis. Br J Gen Pract. 2023;73(733):e566-e574.
Zhou Y, Singh H, Hamilton W et al. Improving the diagnostic process for patients with possible bladder and kidney cancer: a mixed-methods study to identify potential missed diagnostic opportunities. Br J Gen Pract. 2023;73(733):e575-e585.
Shaw B, Walter FM, Hamilton W, Martins T. Symptom appraisal and help seeking in males with symptoms of possible prostate cancer: a qualitative study with an ethnically diverse sample in London. Br J Gen Pract. 2023;73(732):e502-e510.
Sexton V, Atherton H, Dale J, Abel G. Clinician-led secondary triage in England's urgent care delivery: a cross-sectional study. Br J Gen Pract. 2023;73(731):e427-e434.
Merriel SWD, Hall R, Walter FM et al. Systematic Review and Narrative Synthesis of Economic Evaluations of Prostate Cancer Diagnostic Pathways Incorporating Prebiopsy Magnetic Resonance Imaging. Eur Urol Open Sci. 2023;52:123-134.
Blumenfeld TJ, Politi J, Croker S et al. Corrigendum to 'Long-Term Results of Delta Ceramic-On-Ceramic Total Hip Arthroplasty' [Arthroplasty Today Volume 13, February 2022, Pages 130-135]. Arthroplast Today. 2023;21:101141.
Sasieni P, Smittenaar R, Hubbell E et al. Modelled mortality benefits of multi-cancer early detection screening in England. Br J Cancer. 2023;129(1):72-80.
Prado MG, Kessler LG, Au MA et al. Symptoms and signs of lung cancer prior to diagnosis: case-control study using electronic health records from ambulatory care within a large US-based tertiary care centre. BMJ Open. 2023;13(4):e068832.
Hamilton W, Mounce L, Abel GA et al. Protocol for a pragmatic cluster randomised controlled trial assessing the clinical effectiveness and cost-effectiveness of Electronic RIsk-assessment for CAncer for patients in general practice (ERICA). BMJ Open. 2023;13(3):e065232.
Chang WH, Neal RD, Forster MD, Lai AG. Cumulative burden of 144 conditions, critical care hospitalisation and premature mortality across 26 adult cancers. Nat Commun. 2023;14(1):1484.
Parsons J, Abel G, Mounce LT, Atherton H. The changing face of missed appointments. Br J Gen Pract. 2023;73(728):134-135.
Bailey SE, Butler CA, Katsampouris E et al. Determining the role of genetic risk scores in symptomatic cancer detection. Br J Gen Pract. 2023;73(728):106-107.
Smith L, Carmichael J, Cook G et al. Development and Internal Validation of a Risk Prediction Model to Identify Myeloma Based on Routine Blood Tests: A Case-Control Study. Cancers (Basel). 2023;15(3):975.
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