Epidemiology and Public Health group - Publications

Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo CL, Atkins JL, Lewis JR, Duong T, Hong S, Biggs ML, Luan J, Sarnowski C, Lunetta KL, Tanaka T, Wojczynski MK, Cvejkus R, Nethander M, Ghasemi S, Yang J, Zillikens MC, Walter S, Sicinski K, Kague E, Ackert-Bicknell CL, Arking DE, Windham BG, Boerwinkle E, Grove ML, Graff M, Spira D, Demuth I, van der Velde N, de Groot LCPGM, Psaty BM, Odden MC, Fohner AE, Langenberg C, Wareham NJ, Bandinelli S, van Schoor NM, Huisman M, Tan Q, Zmuda J, Mellström D, Karlsson M, Bennett DA, Buchman AS, De Jager PL, Uitterlinden AG, Völker U, Kocher T, Teumer A, Rodriguéz-Mañas L, García FJ, Carnicero JA, Herd P, Bertram L, Ohlsson C, Murabito JM, Melzer D, Kuchel GA, Ferrucci L, Karasik D, Rivadeneira F, Kiel DP, Pilling LC. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women. Nat Commun. 2021 Jan 28;12(1):654. doi: 10.1038/s41467-021-20918-w.
PMID: 33510174

Bowden J, Pilling LC, Türkmen D, Kuo CL, Melzer D. The Triangulation WIthin a STudy (TWIST) framework for causal inference within pharmacogenetic research. PLoS Genet. 2021 Sep 8;17(9):e1009783. doi: 10.1371/journal.pgen.1009783. eCollection 2021 Sep.
PMID: 34495953

Atkins JL, Jylhävä J, Pedersen NL, Magnusson PK, Lu Y, Wang Y, Hägg S, Melzer D, Williams DM, Pilling LC. A genome-wide association study of the frailty index highlights brain pathways in ageing. Aging Cell. 2021 Sep;20(9):e13459. doi: 10.1111/acel.13459. Epub 2021 Aug 25.
PMID: 34431594

Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Tignanelli C, Kuchel GA, Melzer D, Beckman KB, Levine ME. Biological Aging Predicts Vulnerability to COVID-19 Severity in UK Biobank Participants. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):e133-e141. doi: 10.1093/gerona/glab060.
PMID: 33684206

Delgado J, Jones L, Bradley MC, Allan LM, Ballard C, Clare L, Fortinsky RH, Hughes CM, Melzer D. Potentially inappropriate prescribing in dementia, multi-morbidity and incidence of adverse health outcomes. Age Ageing. 2021 Feb 26;50(2):457-464. doi: 10.1093/ageing/afaa147.
PMID: 32946561

Atkins JL, Pilling LC, Heales CJ, Savage S, Kuo CL, Kuchel GA, Steffens DC, Melzer D. Hemochromatosis Mutations, Brain Iron Imaging, and Dementia in the UK Biobank Cohort. J Alzheimers Dis. 2021;79(3):1203-1211. doi: 10.3233/JAD-201080.
PMID: 33427739

Kuo CL, Pilling LC, Atkins JL, Fortinsky RH, Kuchel GA, Melzer D. APOE e4 genotypes increase risk of delirium during COVID-19 related hospitalizations: evidence from a large United Kingdom cohort. J Gerontol A Biol Sci Med Sci. 2021 Jun 25:glab184. doi: 10.1093/gerona/glab184. Online ahead of print.
PMID: 34171089

Pilling LC, Türkmen D, Fullalove H, Atkins JL, Delgado J, Kuo CL, Kuchel GA, Ferrucci L, Bowden J, Masoli JAH, Melzer D. Analysis of CYP2C19 genetic variants with ischaemic events in UK patients prescribed clopidogrel in primary care: a retrospective cohort study. BMJ Open. 2021 Dec 13;11(12):e053905. doi: 10.1136/bmjopen-2021-053905.
PMID: 34903548

2020

Pilling LC, Jones LC, Masoli JAH, Delgado J, Atkins JL, Bowden J, Fortinsky RH, Kuchel GA, Melzer D. Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants. J Am Geriatr Soc. 2021 Feb;69(2):365-372. doi: 10.1111/jgs.16853. Epub 2020 Oct 5.
PMID: 33017050

Atkins JL, Pilling LC, Masoli JAH, Kuo CL, Shearman JD, Adams PC, Melzer D. Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy. JAMA. 2020 Nov 24;324(20):2048-2057. doi: 10.1001/jama.2020.21566.
PMID: 33231665

Colicino E, Marioni R, Ward-Caviness C, Gondalia R, Guan W, Chen B, Tsai PC, Huan T, Xu G, Golareh A, Schwartz J, Vokonas P, Just A, Starr JM, McRae AF, Wray NR, Visscher PM, Bressler J, Zhang W, Tanaka T, Moore AZ, Pilling LC, Zhang G, Stewart JD, Li Y, Hou L, Castillo-Fernandez J, Spector T, Kiel DP, Murabito JM, Liu C, Mendelson M, Assimes T, Absher D, Tsaho PS, Lu AT, Ferrucci L, Wilson R, Waldenberger M, Prokisch H, Bandinelli S, Bell JT, Levy D, Deary IJ, Horvath S, Pankow J, Peters A, Whitsel EA, Baccarelli A. Blood DNA methylation sites predict death risk in a longitudinal study of 12, 300 individuals. Aging (Albany NY). 2020 Jul 22;12(14):14092-14124. doi: 10.18632/aging.103408. Epub 2020 Jul 22.
PMID: 32697766

Atkins JL, Masoli JAH, Delgado J, Pilling LC, Kuo CL, Kuchel GA, Melzer D. Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort. J Gerontol A Biol Sci Med Sci. 2020 Jul 20:glaa183. doi: 10.1093/gerona/glaa183. Online ahead of print.
PMID: 32687551

Tian Q, Pilling LC, Atkins JL, Melzer D, Ferrucci L. The relationship of parental longevity with the aging brain-results from UK Biobank. Geroscience. 2020 Jul 15. doi: 10.1007/s11357-020-00227-8. Online ahead of print.
PMID: 32671621

Kuo CL, Pilling LC, Liu Z, Atkins JL, Levine M. Genetic associations for two biological age measures point to distinct aging phenotypes. medRxiv. 2020 Jul 12:2020.07.10.20150797. doi: 10.1101/2020.07.10.20150797. Preprint.
PMID: 32676622

Kuo CL, Pilling LC, Atkins JC, Masoli J, Delgado J, Tignanelli C, Kuchel G, Melzer D, Beckman KB, Levine M. COVID-19 severity is predicted by earlier evidence of accelerated aging. medRxiv. 2020 Jul 11:2020.07.10.20147777. doi: 10.1101/2020.07.10.20147777. Preprint.
PMID: 32676624

Kuo CL, Melzer D. Response to Comment on "ApoE e4e4 genotype and mortality with COVID-19 in UK Biobank" by Kuo et al. J Gerontol A Biol Sci Med Sci. 2020 Aug 14:glaa198. doi: 10.1093/gerona/glaa198. Online ahead of print.
PMID: 32797154

Chia-Ling Kuo, Luke C Pilling, Janice L Atkins, Jane A H Masoli, João Delgado, George A Kuchel, David Melzer. ApoE e4e4 Genotype and Mortality With COVID-19 in UK Biobank. J Gerontol A Biol Sci Med Sci. 2020 Jul 4;glaa169. doi: 10.1093/gerona/glaa169. Online ahead of print.
PMID: 32623451

Atkins JL, Wannamathee SG. Sarcopenic obesity in ageing: cardiovascular outcomes and mortality. Br J Nutr. 2020 Jun 18:1-12. doi: 10.1017/S0007114520002172. Online ahead of print.
PMID: 32616084

Kuo CL, Pilling LC, Atkins JL, Kuchel GA, Melzer D. ApoE e2 and aging-related outcomes in 379,000 UK Biobank participants. Aging (Albany NY). 2020 Jun 8;12. doi: 10.18632/aging.103405. Online ahead of print.
PMID: 32511104

Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D. APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort. J Gerontol A Biol Sci Med Sci. 2020 May 26:glaa131. doi: 10.1093/gerona/glaa131. Online ahead of print.
PMID: 32451547

Bowman K, Jones L, Masoli J, Mujica-Mota R, Strain D, Butchart J, Valderas JM, Fortinsky RH, Melzer D, Delgado J. Predicting incident delirium diagnoses using data from primary-care electronic health records. Age Ageing. 2020 Apr 27;49(3):374-381. doi: 10.1093/ageing/afaa006.
PMID: 32239180

Masoli JAH, Delgado J, Pilling L, Strain D, Melzer D. Blood pressure in frail older adults: associations with cardiovascular outcomes and all-cause mortality. Age Ageing. 2020 Mar 5:afaa028. doi: 10.1093/ageing/afaa028. Online ahead of print.
PMID: 32133525

Haque S, Ames RM, Moore K, Pilling LC, Peters LL, Bandinelli S, Ferrucci L, Harries LW. circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan. Geroscience. 2020 Feb;42(1):183-199. doi: 10.1007/s11357-019-00120-z. Epub 2019 Dec 6.
PMID: 31811527

Delgado J, Bowman K, Clare L. Potentially inappropriate prescribing in dementia: a state-of-the-art review since 2007. BMJ Open. 2020 Jan 2;10(1):e029172. doi: 10.1136/bmjopen-2019-029172.
PMID: 31900263

Newman AB, Kritchevsky SB, Guralnik JM, Cummings SR, Salive M, Kuchel GA, Schrack J, Morris MC, Weir D, Baccarelli A, Murabito JM, Ben-Shlomo Y, Espeland MA, Kirkland J, Melzer D, Ferrucci L. Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology. J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):77-86. doi: 10.1093/gerona/glz230.
PMID: 31722007

Melzer D, Pilling LC, Ferrucci L. The genetics of human ageing. Nat Rev Genet. 2020 Feb;21(2):88-101. doi: 10.1038/s41576-019-0183-6. Epub 2019 Nov 5. Review.
PMID: 31690828

2019

Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries LW, Pilling LC, Melzer D. Corrigendum to: The Longevity-Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects. J Gerontol A Biol Sci Med Sci. 2019 Nov 29. pii: glz268. doi: 10.1093/gerona/glz268. [Epub ahead of print] No abstract available.
PMID: 31783406

Atkins JL, Delgado J, Melzer D. Life's Simple 7 likely to be associated with dementia risk reduction in both midlife and older age groups. BMJ. 2019 Sep 12;366:l5491. doi: 10.1136/bmj.l5491.
PMID: 31515223

Kuo CL, Pilling LC, Kuchel GA, Ferrucci L, Melzer D. Telomere length and aging-related outcomes in humans: A Mendelian randomization study in 261,000 older participants. Aging Cell. 2019 Aug 24:e13017. doi: 10.1111/acel.13017. [Epub ahead of print]
PMID: 31444995

Kuo CL, Joaquim M, Kuchel GA, Ferrucci L, Harries L, Pilling LC, Melzer D. The Longevity Associated Sh2b3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects. J Gerontol A Biol Sci Med Sci. 2019 Aug 20. pii: glz191. doi: 10.1093/gerona/glz191. [Epub ahead of print]
PMID: 31428775

Lee BP, Pilling LC, Bandinelli S, Ferrucci L, Melzer D, Harries LW. The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood. Biogerontology. 2019 Oct;20(5):649-663. doi: 10.1007/s10522-019-09819-0. Epub 2019 Jul 10.
PMID: 31292793

Kositsawat J, Kuo CL, Barry L, Melzer D, Bandinelli S, Ferrucci L, Wu R, Kuchel GA. Interaction between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-year Follow-up Data of Older Adults from InCHIANTI. J Gerontol A Biol Sci Med Sci. 2019 Jul 6. pii: glz165. doi: 10.1093/gerona/glz165. [Epub ahead of print]
PMID: 31282535

Odden MC, Melzer D. Machine Learning in Aging Research. J Gerontol A Biol Sci Med Sci. 2019 Mar 22. pii: glz074. doi: 10.1093/gerona/glz074. [Epub ahead of print]
PMID: 30903146

Masoli JAH, Delgado J, Bowman K, Strain WD, Henley W, Melzer D. Association of blood pressure with clinical outcomes in older adults with chronic kidney disease. Age Ageing. 2019 Feb 28. pii: afz006. doi: 10.1093/ageing/afz006. [Epub ahead of print]
PMID: 30824915 

Jones G, Pilling LC, Kuo CL, Kuchel G, Ferrucci L, Melzer D. Sarcopenia and variation in the Human Leukocyte Antigen complex. J Gerontol A Biol Sci Med Sci. 2019 Feb 17. pii: glz042. doi: 10.1093/gerona/glz042. [Epub ahead of print]
PMID: 30772894

Bowman K, Jones L, Pilling LC, Delgado J, Kuchel GA, Ferrucci L, Fortinsky RH, Melzer D. Vitamin D levels and risk of delirium: A mendelian randomization study in the UK Biobank. Neurology. 2019 Feb 15. pii: 10.1212/WNL.0000000000007136. doi: 10.1212/WNL.0000000000007136. [Epub ahead of print]
PMID: 30770424

Bowman K, Thambisetty M, Kuchel GA, Ferrucci L, Melzer D. Obesity and Longer Term Risks of Dementia in 65-74 Year Olds. Age Ageing. 2019 Feb 6. doi: 10.1093/ageing/afz002. [Epub ahead of print]
PMID: 30726871

Tamosauskaite J, Atkins JL, Pilling LC, Kuo CL, Kuchel GA, Ferrucci L, Melzer D. Hereditary Hemochromatosis Associations with Frailty, Sarcopenia and Chronic Pain: Evidence from 200,975 Older UK Biobank Participants. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):337-342. doi: 10.1093/gerona/gly270.
PMID: 30657865

Pilling LC, Tamosauskaite J, Jones G, Wood AR, Jones L, Kuo CL, Kuchel GA, Ferrucci L, Melzer D. Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank. BMJ. 2019 Jan 16;364:k5222. doi: 10.1136/bmj.k5222.
PMID: 30651232

2018

Masoli JAH, Pilling LC, Kuchel GA, Melzer D. Clinical Outcomes of CADASIL-Associated NOTCH3 Mutations in 451,424 European Ancestry Community Volunteers. Transl Stroke Res. 2018 Oct 18: doi: 10.1007/s12975-018-0671-6. [Epub ahead of print] No abstract available.
PMID: 30338453

Pilling LC, Atkins JL, Kuchel GA, Ferrucci L, Melzer D. Red cell distribution width and common disease onsets in 240,477 health volunteers followed for up to 9 years. PLoS One. 2018 Sep 13;13(9):e0203504. doi: 10.1371/journal/pone.0203504. eCollection 2018.
PMID: 30212481

Atkins JL, Delgado J, Pilling LC, Bowman K, Masoli JAH, Kuchel GA, Ferrucci L, Melzer D. Impact of Low Cardiovascular Risk Profiles on Geriatric Outcomes: Evidence From 421,000 Participants in Two Cohorts. J Gerontol A Biol Sci Med Sci. 2018 May 21. doi: 10.1093/gerona/gly083. [Epub ahead of print]
PMID: 29982474

Zirk-Sadowski J, Masoli JA, Delgado J, Hamilton W, Strain WD, Henley W, Melzer D, Ble A. Proton-Pump Inhibitors and Long-Term Risk of Community-Acquired Pneumonia in Older Adults. J Am Geriatr Soc. 2018 Jul;66(7):1332-1338. doi: 10.111/jgs. 15385. Epub 2018 Apr 20.
PMID: 29676433

Latorre E, Pilling LC, Lee BP, Bandinelli S, Melzer D, Ferrucci L, Harries LW. The VEGFA₁₆₅b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease. Clin Sci (Lond). 2018 Jan 12. pii: CS20171556. doi: 10.1042/CS20171556. [Epub ahead of print]
PMID: 29330351

Delgado J, Bowman K, Ble A, Masoli J, Han Y, Henley W, Welsh S, Kuchel GA, Ferrucci L, Melzer D. Blood Pressure Trajectories in the 20 Years Before Death. JAMA Intern Med. 2018 Jan 1;178(1):93-99. doi: 10.1001/jamainternmed.2017.7023.
PMID: 29204655

2017

Pilling LC, Kuo CL, Sicinski K, Tamosauskaite J, Kuchel GA, Harries LW, Herd P, Wallace R, Ferrucci L, Melzer D. Human longevity: 25 genetic loci associated in 389,166 UK biobank participants. Aging (Albany NY). 2017 Dec 6;9(12):2504-2520. doi: 10.18632/aging.101334.
PMID: 29227965

Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, Harries LW. Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol. 2017 Oct 17;18(1):31. doi: 10.1186/s12860-017-0147-7.
PMID: 29041897

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo CL, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Murray A, Weedon MN, Harries LW, Kuchel GA, Ferrucci L, Frayling TM, Melzer D. Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One. 2017 Sep 28;12(9):e0185083. doi: 10.1371/journal.pone.0185083. eCollection 2017.
PMID: 28957414

Bowman K, Melzer D. Reply to WG Thompson. Am J Clin Nutr. 2017 Sep;106(3):959. doi: 10.3945/ajcn.117.162115.
PMID: 28864591

Bowman K, Atkins JL, Delgado J, Kos K, Kuchel GA, Ble A, Ferrucci L, Melzer D. Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants. Am J Clin Nutr. 2017 Jul;106(1):130-135. doi: 10.3945/ajcn.116.147157. Epub 2017 May 31.
PMID: 28566307

Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D, Henley WE. Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review. J Clin Epidemiol. 2017 Jul;87:23-34. doi: 10.1016/j.jclinepi.2017.04.022. Epub 2017 Apr 28. Review.
PMID: 28460857

Smallwood MJ, Ble A, Melzer D, Winyard PG, Benjamin N, Shore AC, Gilchrist M. Relationship Between Urinary Nitrate Excretion and Blood Pressure in the InChianti Cohort. Am J Hypertens. 2017 Jul 1;30(7):707-712. doi: 10.1093/ajh/hpx035.
PMID: 28430835

Lee BP, Burić I, George-Pandeth A, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Melzer D, Harries LW. MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Sci Rep. 2017 Mar 17;7:44620. doi: 10.1038/srep44620.
PMID: 28304372

Zirk-Sadowski J, Masoli JA, Strain WD, Delgado J, Henley W, Hamilton W, Melzer D, Ble A. Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients. Am J Gastroenterol. 2017 Mar;112(3):520-523. doi: 10.1038/ajg.2016.584.
PMID: 28270664

2016

Huan T, Joehanes R, Schurmann C, Schramm K, Pilling LC, et al. A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking. Hum Mol Genet. 2016 Nov 1;25(21):4611-4623. doi: 10.1093/hmg/ddw288.
PMID: 28158590

Delgado J, Masoli JAH, Bowman K, Strain WD, Kuchel GA, Walters K, Lafortune L, Brayne C, Melzer D, Ble A; As part of the Ageing Well Programme of the NIHR School for Public Health Research, England. Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals. J Am Geriatr Soc. 2017 May;65(5):995-1003. doi: 10.1111/jgs.14712. Epub 2016 Dec 30.
PMID: 28039870

Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, et al. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol. 2016 Dec 12;17(1):255.
PMID: 27955697

Tanaka T, Dutta A, Pilling LC, Xue L, Lunetta KL, Murabito JM, Bandinelli S, Wallace R, Melzer D, Ferrucci L. Genome-wide Association Study of Parental Life Span. J Gerontol A Biol Sci Med Sci. 2016 Nov 5. pii: glw206. [Epub ahead of print]
PMID: 27816938

Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, et al. Epigenetic Signatures of Cigarette Smoking. Circ Cardiovasc Genet. 2016 Oct;9(5):436-447. Epub 2016 Sep 20.
PMID: 27651444

Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, et al. DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging (Albany NY). 2016 Sep 28;8(9):1844-1865. doi: 10.18632/aging.101020.
PMID: 27690265

Chen BH, Hivert MF, Peters MJ, Pilling LC, Hogan JD, et al. Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations. Diabetes. 2016 Dec;65(12):3794-3804. Epub 2016 Sep 13.
PMID: 27625022

McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR, et al. A reference panel of 64,976 haplotypes for genotype imputation. Nat Genet. 2016 Oct;48(10):1279-83. doi: 10.1038/ng.3643. Epub 2016 Aug 22.
PMID: 27548312

Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine JM, Kuchel GA, Ferrucci L, Melzer D. Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up In 186,000 U.K. Biobank Participants. J Am Coll Cardiol. 2016 Aug 23;68(8):874-5. doi: 10.1016/j.jacc.2016.05.072.
PMID: 27539182

Bowman K, Delgado J, Henley WE, Masoli JA, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel GA, Ble A, Melzer D; as part of the Ageing Well Programme of the NIHR School for Public Health Research, England. Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):203-209. doi: 10.1093/gerona/glw147. Epub 2016 Aug 4.
PMID: 27492450

Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW. Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell. 2016 Oct;15(5):903-13. doi: 10.1111/acel.12499. Epub 2016 Jun 30.
PMID: 27363602

Ble A, Hughes PM, Delgado J, Masoli JA, Bowman K, Zirk-Sadowski J, Mujica Mota RE, Henley WE, Melzer D. Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: A Quasi-Experimental Study. J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):243-250. doi: 10.1093/gerona/glw082. Epub 2016 May 4.
PMID: 27146371

Ruth KS, Perry JR, Henley WE, Melzer D, Weedon MN, Murray A. Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study. Sci Rep. 2016 Apr 20;6:24710. doi: 10.1038/srep24710.
PMID: 27094806

Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, et al. Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY). 2016 Mar;8(3):547-60.
PMID: 27015805

2015

Ble A, Masoli JA, Barry HE, Winder RE, Tavakoly B, Henley WE, Kuchel GA, Valderas JM, Melzer D, Richards SH. Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12. BMC Geriatr. 2015 Nov 5;15:146. doi: 10.1186/s12877-015-0143-8.
PMID: 26542116

Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, et al. The transcriptional landscape of age in human peripheral blood. Nat Commun. 2015 Oct 22;6:8570. doi: 10.1038/ncomms9570.
PMID: 26490707

Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, et al. Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics. 2016 Jan;48(1):1-11. doi: 10.1152/physiolgenomics.00054.2015. Epub 2015 Oct 20.
PMID: 26487704

Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, et al. Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol. 2015 Jun 16;70:37-45. doi: 10.1016/j.exger.2015.05.012. [Epub ahead of print]
PMID: 26087330

Westra HJ, Arends D, Esko T, Peters MJ, Schurmann C, et al. Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet. 2015 May 8;11(5):e1005223. doi: 10.1371/journal.pgen.1005223. eCollection 2015.
PMID: 25955312

Hardcastle AC, Mounce LTA, Richards SH, Bachmann MO, Clark A, Henley WE, Campbell JL, Melzer D, Steel N. The dynamics of quality: a national panel study of evidence-based standards. Southampton (UK): NIHR Journals Library; 2015 Mar.
PMID: 25834881

Huan T, Esko T, Peters MJ, Pilling LC, Schramm K, et al. A meta-analysis of gene expression signatures of blood pressure and hypertension. PLoS Genet. 2015 Mar 18;11(3):e1005035. doi: 10.1371/journal.pgen.1005035. eCollection 2015.
PMID: 25785607

Holly AC, Grellscheid S, van de Walle P, Dolan D, Pilling LC, Daniels DJ, von Zglinicki T, Ferrucci L, Melzer D, Harries LW. Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts. Biogerontology. 2015 Aug;16(4):423-34. doi: 10.1007/s10522-015-9560-5. Epub 2015 Feb 21.
PMID: 25700689

Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, et al. DNA methylation of lipid-related genes affects blood lipid levels. Circ Cardiovasc Genet. 2015 Apr;8(2):334-42. doi: 10.1161/CIRCGENETICS.114.000804. Epub 2015 Jan 12.
PMID: 25583993

Littlejohns TJ, Kos K, Henley WE, Cherubini A, Ferrucci L, Lang IA, Langa KM, Melzer D, Llewellyn DJ. Serum leptin and risk of cognitive decline in elderly italians. J Alzheimers Dis. 2015;44(4):1231-9. doi: 10.3233/JAD-141836
PMID: 25502764

2014

Mounce LT, Steel N, Hardcastle AC, Henley WE, Bachmann MO, Campbell JL, Clark A, Melzer D, Richards SH. Patient characteristics predicting failure to receive indicated care for type 2 diabetes. Diabetes Res Clin Pract. 2015 Feb;107(2):247-58. doi: 10.1016/j.diabres.2014.11.009. Epub 2014 Dec 3.
PMID: 25533855

Blackwell J, Harries LW, Pilling LC, Ferrucci L, Jones A, Melzer D. Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise. J Physiol Sci. 2015 Jan;65(1):145-50. doi: 10.1007/s12576-014-0350-7. Epub 2014 Nov 13.
PMID: 25391587

Wood AR, Tuke MA, Nalls M, Hernandez D, Gibbs JR, et al. Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes. Hum Mol Genet. 2015 Mar 1;24(5):1504-12. doi: 10.1093/hmg/ddu560. Epub 2014 Nov 6.
PMID: 25378555

Steel N, Hardcastle AC, Bachmann MO, Richards SH, Mounce LT, Clark A, Lang I, Melzer D, Campbell J. Economic inequalities in burden of illness, diagnosis and treatment of five long-term conditions in England: panel study. BMJ Open. 2014 Oct 24;4(10):e005530. doi: 10.1136/bmjopen-2014-005530.
PMID: 25344482

Lin H, Joehanes R, Pilling LC, Dupuis J, Lunetta KL, et al Whole Blood Gene Expression and Interleukin-6 Levels. Genomics. 2014 Oct 10. pii: S0888-7543(14)00195-5. doi: 10.1016/j.ygeno.2014.10.003. [Epub ahead of print]
PMID: 25311648

Wood AR, Tuke MA, Nalls MA, Hernandez DG, Bandinelli S, Singleton AB, Melzer D, Ferrucci L, Frayling TM, Weedon MN. Another explanation for apparent epistasis. Nature. 2014 Oct 2;514(7520):E3-5. doi: 10.1038/nature13691. No abstract available.
PMID: 25279928

Melzer D, Tavakoly B, Winder RE, Masoli JA, Henley WE, Ble A, Richards SH. Much more medicine for the oldest old: trends in UK electronic clinical records. Age Ageing. 2014 Aug 7. pii: afu113. [Epub ahead of print]
PMID: 25103030

Steel N, Hardcastle AC, Clark A, Mounce LT, Bachmann MO, Richards SH, Henley WE, Campbell JL, Melzer D. Self-reported quality of care for older adults from 2004 to 2011: a cohort study. Age Ageing. 2014 Sep;43(5):716-20. doi: 10.1093/ageing/afu091. Epub 2014 Jul 11.
PMID: 25015897

Holly AC, Pilling LC, Hernandez D, Lee BP, Singleton A, Ferrucci L, Melzer D, Harries LW. Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mech Ageing Dev. 2014 Jan;135:50-6. doi: 10.1016/j.mad.2014.01.005. Epub 2014 Jan 23.
PMID: 24463145

Cipelli R, Harries L, Okuda K, Yoshihara S, Melzer D, Galloway T. Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells. Reproduction. 2014 Mar 2;147(4):419-26. doi: 10.1530/REP-13-0423. Print 2014.
PMID: 24231368

2013

Tyrrell J, Galloway TS, Abo-Zaid G, Melzer D, Depledge MH, Osborne NJ. High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010. PLoS One. 2013 Nov 11;8(11):e77546. doi: 10.1371/journal.pone.0077546. eCollection 2013.
PMID: 24244278

Dutta A, Henley W, Robine JM, Llewellyn D, Langa KM, Wallace RB, Melzer D. Aging children of long-lived parents experience slower cognitive decline. Alzheimers Dement. 2013 Nov 6. pii: S1552-5260(13)02496-5. doi: 10.1016/j.jalz.2013.07.002. [Epub ahead of print]
PMID: 24210527

Westra HJ, Peters MJ, Esko T, Yaghootkar H, Schurmann C, et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet. 2013 Oct;45(10):1238-43. doi: 10.1038/ng.2756. Epub 2013 Sep 8.
PMID: 24013639

Tyrrell J, Melzer D, Henley W, Galloway TS, Osborne NJ. Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010. Environ Int. 2013 Jul 23;59C:328-335. [Epub ahead of print]
PMID: 23892225

Fletcher T, Galloway TS, Melzer D, Holcroft P, Cipelli R, Pilling LC, Mondal D, Luster M, Harries LW. Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans. Environ Int. 2013 Jul;57-58:2-10. Epub 2013 Apr 24.
PMID: 23624243

Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW. Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev. 2013 Jun 6. [Epub ahead of print]
PMID: 23747814

Wood AR, Perry JR, Tanaka T, Hernandez DG, Zheng HF, et al. Imputation of variants from the 1000 Genomes Project modestly improves know associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation. PLoS One. 2013 May 16;8(5):e64343. Print 2013.
PMID: 23696881

Dutta A, Henley W, Robine JM, Langa KM, Wallace RB, Melzer D. Longer lived parents: protective associations with cancer incidence and overall mortality. J Gerontol A Biol Sci Med Sci. 2013 May 16. [Epub ahead of print]
PMID: 23685624

Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, et al. Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet. 2013 May 15;22(10):2119-27. Epub 2013 Jan 12.
PMID: 23314186

Hek K, Demirkan A, Lahti J, Terracciano A, Teumer A, et al. A genome-wide association study of depressive symptoms. Biol Psychiatry. 2013 Apr 1;73(7):667-78. Epub 2013 Jan 3.
PMID: 23290196

Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW. Towards a gene expression biomarker set for human biological age. Aging Cell. 2013 Apr;12(2):234-6. Epub 2013 Jan 30.
PMID: 23311345

Dutta A, Henley W, Pilling LC, Wallace RB, Melzer D. Uric acid measurement improves prediction of cardiovascular mortality in later life. J Am Geriatr Soc. 2013 Mar;61(3):319-26.
PMID: 23496291

Antoniou EE, Dutta A, Langa KM, Melzer D, Llewelllyn D. Personality profile of the children of long-lived parents. J Gerontol B Psychol Sci Soc Sci. 2013 Feb 18. [Epub ahead of print]
PMID: 23419869

2012

Stephan BC, Hunter S, Harris D, Llewellyn DJ, Siervo M, Matthews FE, Brayne C. The neuropathological profile of mild cognitive impairment (MCI): a systematic review. Mol Psychiatry. 2012 Nov;17(11):1056-76. Epub 2011 Dec 6.
PMID: 22143004

Melzer D, Gates P, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, Grainger D, Galloway TS. Urinary bisphenol A concentration and angiography-defined coronary artery stenosis.PLoS One. 2012;7(8):e43378. Epub 2012 Aug 15.
PMID: 22916252

Harries LW, Fellows AD, Pilling LC, Hernandez D, Singleton A, Bandinelli S, Guralnik J, Powell J, Ferrucci L, Melzer D. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mech Ageing Dev. 2012 Aug;133(8):556-62. Epub 2012 Jul 16.
PMID: 22813852

Harries LW, Bradley-Smith RM, Llewellyn DJ, Pilling LC, Fellows A, Henley W, Hernandez D, Guralnik JM, Bandinelli S, Singleton A, Ferrucci L, Melzer D. Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults. Rejuvenation Res. 2012 Aug;15(4):395-404. Epub 2012 May 18.
PMID: 22607625

Pilling LC, Harries LW, Powell J, Llewellyn DJ, Ferrucci L, Melzer D. Genomics and successful aging: grounds for renewed optimism? J Gerontol A Biol Sci Med Sci. 2012. May;67(5):511-9. Epub 2012 Mar 27.
PMID: 22454374

Soni M, Kos K, Lang IA, Jones K, Melzer D, Llewellyn DJ. Vitamin D and cognitive function. Scand J Clin Lab Invest Suppl. 2012 Apr;243:79-82.
PMID: 22536767

Harries LW, Pilling LC, Hernandez LD, Bradley-Smith R, Henley W, Singleton AB, Guralnik JM, Bandinelli S, Ferrucci L, Melzer D. CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength. Aging Cell. 2012 Apr;11(2):262-268. doi: 10.1111/j.1474-9726.2011.00782.x. Epub 2012 Jan 13.
PMID: 22152057

Melzer D, Osborne NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Luben R, Khaw KT, Wareham NJ, Galloway TS. Urinary Bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women. Circulation. 2012 Mar 27;125(12):1482-90. Epub 2012 Feb 21.
PMID: 22354940

Murabito JM, White CC, Kavousi M, Sun YV, Feitosa MF, et al. Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies. Circ Cardiovasc Genet. 2012 Feb 1;5(1):100-12. Epub 2011 Dec 23.
PMID: 22199011

Stolk L, Perry JR, Chasman DI, He C, Mangino M, et al. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet. 2012 Jan 22;44(3):260-8. doi: 10.1038/ng.1051.
PMID: 22267201

2011

Melzer D, Harries L, Cipelli R, Henley W, Money C, McCormack P, Young A, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Galloway T. Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults. Environ Health Perspect. 2011 Dec;119(12):1788-93. Epub 2011 Aug 10.
PMID: 21831745                   

Wills M, Akbar A, Beswick M, Bosch JA, Caruso C, et al. Report from the Second Cytomegalovirus and Immunosenescence Workshop. Immun Ageing. 2011 Oct 28;8(1):10. [Epub ahead of print] 
PMID: 22035114

Wood AR, Hernandez DG, Nalls MA, Yaghootkar H, Gibbs JR, et al. Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association. Hum Mol Genet. 2011 Oct 15;20(20):4082-92. Epub 2011 Jul 28. 
PMID: 21798870

Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JR, et al. Genetic determinants of serum testosterone concentrations in men. PLoS Genet. 2011 Oct;7(10):e1002313. Epub 2011 Oct 6. 
PMID: 21998597

Dutta A, Henley W, Lang IA, Murray A, Guralnik J, Wallace RB, Melzer D. The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction. Circ Cardiovasc Genet. 2011 Oct;4(5):542-8. Epub 2011 Aug 18. 
PMID: 21852414

Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, et al. Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell. 2011 Oct;10(5):868-78. doi: 10.1111/j.1474-9726.2011.00726.x. Epub 2011 Jul 19. 
PMID: 21668623

Melzer D, Galloway T. Bisphenol A and adult disease: making sense of fragmentary data and competing inferences. Ann Intern Med. 2011 Sep 20;155(6):392-4. 
PMID: 21930858

Dickens AP, Lang IA, Langa KM, Kos K, Llewellyn DJ. Vitamin D, cognitive dysfunction and dementia in older adults. CNS Drugs. 2011 Aug;25(8):629-39. doi: 10.2165/11593080-000000000-00000. 
PMID: 21790207

Lang IA, Llewellyn DJ, Hubbard RE, Langa KM, Melzer D. Income and the midlife peak in common mental disorder prevalence. Psychol Med. 2011 Jul;41(7):1365-72. Epub 2010 Dec 10. 
PMID: 21144109

Nalls MA, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, et al. Multiple loci are associated with white blood cell phenotypes. PLoS Genet. 2011 Jun;7(6):e1002113. Epub 2011 Jun 30. 
PMID: 21738480

Dutta A, Henley W, Lang I, Llewellyn D, Guralnik J, Wallace RB, Melzer D. Predictors of extraordinary survival in the Iowa established populations for epidemiologic study of the elderly: cohort follow-up to "extinction". J Am Geriatr Soc. 2011 Jun;59(6):963-71. doi: 10.1111/j.1532-5415.2011.03451.x. Epub 2011 Jun 7. 
PMID: 21649635

Zhai G, Teumer A, Stolk L, Perry JR, Vandenput L, et al. Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. PLoS Genet. 2011 Apr;7(4):e1002025. Epub 2011 Apr 14.
PMID: 21533175

Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Potter GG, Langa KM. Neuropsychiatric symptoms and the risk of institutionalization and death: the aging, demographics, and memory study. J Am Geriatr Soc. 2011 Mar;59(3):473-81. doi: 10.1111/j.1532-5415.2011.03314.x. 
PMID: 21391937

Fisher GG, Franks MM, Plassman BL, Brown SL, Potter GG, Llewellyn D, Rogers MA, Langa KM.Caring for individuals with dementia and cognitive impairment, not dementia: findings from the aging, demographics, and memory study. J Am Geriatr Soc. 2011 Mar;59(3):488-94. doi: 10.1111/j.1532-5415.2010.03304.x. 
PMID:  21391939

Simanek AM, Dowd JB, Pawelec G, Melzer D, Dutta A, Aiello AE. Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States. PLoS One. 2011 Feb 17;6(2):e16103. 
PMID: 21379581

Rice NE, Lang IA, Henley W, Melzer D. Common health predictors of early retirement: findings from the English Longitudinal Study of Ageing. Age Ageing. 2011 Jan;40(1):54-61. 
PMID: 21148324

Llewellyn DJ, Lang IA, Langa KM, Melzer D. Vitamin D and cognitive impairment in the elderly U.S. population. J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):59-65. Epub 2010 Nov 1. 
PMID: 21041201

2010

Strain WD, Shore AC, Melzer D. Albumin:creatinine ratio predicts mortality after stroke: analysis of the Third National Health and Nutrition Examination Survey. J Am Geriatr Soc. 2010 Dec;58(12):2434-5. doi: 10.1111/j.1532-5415.2010.03158.x. 
PMID: 21143450

Galloway T, Cipelli R, Guralnik J, Ferrucci L, Bandinelli S, Corsi AM, Money C, McCormack P, Melzer D. Daily bisphenol A excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study.  Environ Health Perspect. 2010 Nov;118(11):1603-8. 
PMID: 20797929

Zivin K, Llewellyn DJ, Lang IA, Vijan S, Kabeto MU, Miller EM, Langa KM. Depression among older adults in the United States and England. Am J Geriatr Psychiatry. 2010 Nov;18(11):1036-44. 
PMID: 20808088

Cluett C, Brayne C, Clarke R, Evans G, Matthews F, et al. Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiol Aging. 2010 Sep;31(9):1563-8. Epub 2008 Oct 9. 
PMID: 18848371

Llewellyn DJ, Lang IA, Langa KM, Muniz-Terrera G, Phillips CL, Cherubini A, Ferrucci L, Melzer D.Vitamin D and risk of cognitive decline in elderly persons. Arch Intern Med. 2010 Jul 12;170(13):1135-41. 
PMID: 20625021

Llewellyn DJ, Lang IA, Matthews FE, Plassman BL, Rogers MA, Morgenstern LB, Fisher GG, Kabeto MU, Langa KM. Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. Alzheimers Res Ther. 2010 Jun 24;2(3):19. 
PMID: 20576093

Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS. Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey. Environ Health Perspect. 2010 May;118(5):686-92. Epub 2010 Jan 7. 
PMID: 20089479

Rice NE, Lang IA, Henley W, Melzer D. Baby boomers nearing retirement: the healthiest generation? Rejuvenation Res. 2010 Feb;13(1):105-14. 
PMID: 20230284

Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010 Feb;42(2):105-16. Epub 2010 Jan 17. Erratum in: Nat Genet. 2010 May;42(5):464. 
PMID: 20081858

Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):377-81. Epub 2009 Nov 25. 
PMID: 19942592

Dalton HR, Bendall RP, Pritchard C, Henley W, Melzer D. National mortality rates from chronic liver disease and consumption of alcohol and pig meat. Epidemiol Infect. 2010 Feb;138(2):174-82. Epub 2009 Jun 29. 
PMID: 19563698

Okura T, Plassman BL, Steffens DC, Llewellyn DJ, Potter GG, Langa KM. Prevalence of neuropsychiatric symptoms and their association with functional limitations in older adults in the United States: the aging, demographics, and memory study. J Am Geriatr Soc. 2010 Feb;58(2):330-7. Epub 2010 Jan 26. 
PMID: 20374406

Llewellyn DJ, Langa KM, Friedland RP, Lang IA. Serum albumin concentration and cognitive impairment. Curr Alzheimer Res. 2010 Feb;7(1):91-6. 
PMID: 20205675

Melzer D, Rice NE, Lewis C, Henley WE, Galloway TS. Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06. PLoS One. 2010 Jan 13;5(1):e8673. 
PMID: 20084273

2009

Richards JB, Waterworth D, O'Rahilly S, Hivert MF, Loos RJ, et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009 Dec;5(12):e1000768. Epub 2009 Dec 11. 
PMID: 20011104

Thomas K, Rafiq S, Frayling TM, Ebrahim S, Kumari M, Gallacher J, Ferrucci L, Bandinelli S, Wallace RB, Melzer D, Martin RM, Ben-Shlomo Y. Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis. J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1177-82. Epub 2009 Jul 24. 
PMID: 19633236

Potter GG, Plassman BL, Burke JR, Kabeto MU, Langa KM, Llewellyn DJ, Rogers MA, Steffens DC.Cognitive performance and informant reports in the diagnosis of cognitive impairment and dementia in African Americans and whites. Alzheimers Dement. 2009 Nov;5(6):445-53. 
PMID: 19896583

Kapur N, Hutchinson P, Berry E, Hawkins K, Llewellyn D, Wilson B. Executive dysfunction in a case of transoral-frontal self-inflicted gunshot injury. Brain Inj. 2009 Nov;23(12):985-9. 
PMID: 19831496

Lang IA, Hubbard RE, Andrew MK, Llewellyn DJ, Melzer D, Rockwood K. Neighborhood deprivation, individual socioeconomic status, and frailty in older adults. J Am Geriatr Soc. 2009 Oct;57(10):1776-80. Epub 2009 Sep 15. 
PMID: 19754500

Perry JR, Ferrucci L, Bandinelli S, Guralnik J, Semba RD, et al. Circulating beta-carotene levels and type 2 diabetes-cause or effect? Diabetologia. 2009 Oct;52(10):2117-21. Epub 2009 Aug 7. 
PMID: 19662379

Rice NE, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Miller MA, Kumari M, Murray A, Frayling TM, Melzer D. The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies. Int J Epidemiol. 2009 Oct;38(5):1374-9. Epub 2009 Aug 3. 
PMID: 19651761

Cluett C, Melzer D. Human genetic variations: Beacons on the pathways to successful ageing.Mech Ageing Dev. 2009 Sep;130(9):553-63. Epub 2009 Jul 4. Review. 
PMID: 19580824

Llewellyn DJ, Langa KM, Lang IA. Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol. 2009 Sep;22(3):188-95. Epub 2008 Dec 10. 
PMID: 19073839

Cluett C, McDermott MM, Guralnik J, Ferrucci L, Bandinelli S, et al. The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people. Circ Cardiovasc Genet. 2009 Aug;2(4):347-53. Epub 2009 Jun 23. 
PMID: 20031606

Murray A, Cluett C, Bandinelli S, Corsi AM, Ferrucci L, Guralnik J, Singleton A, Frayling T, Melzer D.Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people. Eur Heart J. 2009 Jul;30(14):1711-9. Epub 2009 May 12. 
PMID: 19435741

Llewellyn DJ, Matthews FE. Increasing levels of semantic verbal fluency in elderly English adults.Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2009 Jul;16(4):433-45. Epub 2009 Mar 25. 
PMID: 19319746

Langa KM, Llewellyn DJ, Lang IA, Weir DR, Wallace RB, Kabeto MU, Huppert FA. Cognitive health among older adults in the United States and in England. BMC Geriatr. 2009 Jun 25;9:23. 
PMID: 19555494

Lang IA, Melzer D. Moderate alcohol consumption in later life: time for a trial? J Am Geriatr Soc. 2009 Jun;57(6):1110-2. 
PMID: 19490244

Rogers MA, Plassman BL, Kabeto M, Fisher GG, McArdle JJ, Llewellyn DJ, Potter GG, Langa KM.Parental education and late-life dementia in the United States. J Geriatr Psychiatry Neurol. 2009 Mar;22(1):71-80. Epub 2008 Dec 10. 
PMID: 19073840

Llewellyn DJ, Lang IA, Langa KM, Naughton F, Matthews FE. Exposure to secondhand smoke and cognitive impairment in non-smokers: national cross sectional study with cotinine measurement.BMJ. 2009 Feb 12;338:b462. doi: 10.1136/bmj.b462. 
PMID: 19213767

Ferrucci L, Perry JR, Matteini A, Perola M, Tanaka T, et al. Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet. 2009 Feb;84(2):123-33. Epub 2009 Jan 29. 
PMID: 19185284

Parahyba MI, Stevens K, Henley W, Lang IA, Melzer D. Reductions in disability prevalence among the highest income groups of older Brazilians. Am J Public Health. 2009 Jan;99(1):81-6. Epub 2008 Nov 13. 
PMID: 19008509

Lang IA, Scarlett A, Guralnik JM, Depledge MH, Melzer D, Galloway TS. Age-related impairments of mobility associated with cobalt and other heavy metals: data from NHANES 1999-2004. J Toxicol Environ Health A. 2009;72(6):402-9. 
PMID: 19199147

Rafiq S, Melzer D, Weedon MN, Lango H, Saxena R, et al. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia. 2008 Dec;51(12):2205-13. Epub 2008 Oct 14. 
PMID: 18853133

Lang IA, Gibbs SJ, Steel N, Melzer D. Neighbourhood deprivation and dental service use: a cross-sectional analysis of older people in England. J Public Health (Oxf). 2008 Dec;30(4):472-8. Epub 2008 Jun 27. 
PMID: 18587145

Llewellyn DJ, Lang IA, Langa KM, Huppert FA. Cognitive function and psychological well-being: findings from a population-based cohort. Age Ageing. 2008 Nov;37(6):685-9. Epub 2008 Oct 13. 
PMID: 18852289

Yuan X, Waterworth D, Perry JR, Lim N, Song K, et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet. 2008 Oct;83(4):520-8. 
PMID: 18940312

Rice NE, Patel BD, Lang IA, Kumari M, Frayling TM, Murray A, Melzer D. Filaggrin gene mutations are associated with asthma and eczema in later life. J Allergy Clin Immunol. 2008 Oct;122(4):834-6. Epub 2008 Aug 29. 
PMID: 18760831

Lang IA, Galloway TS, Scarlett A, Henley WE, Depledge M, Wallace RB, Melzer D. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults.JAMA. 2008 Sep 17;300(11):1303-10. Epub 2008 Sep 16. 
PMID: 18799442

Steel N, Bachmann M, Maisey S, Shekelle P, Breeze E, Marmot M, Melzer D. Self reported receipt of care consistent with 32 quality indicators: national population survey of adults aged 50 or more in England. BMJ. 2008 Aug 13;337:a957. doi: 10.1136/bmj.a957. 
PMID: 18703659

Lang IA, Llewellyn DJ, Alexander K, Melzer D. Obesity, physical function, and mortality in older adults. J Am Geriatr Soc. 2008 Aug;56(8):1474-8. Epub 2008 Jul 24. 
PMID: 18662211

Panicker V, Cluett C, Shields B, Murray A, Parnell KS, et al. A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab. 2008 Aug;93(8):3075-81. Epub 2008 May 20. 
PMID: 18492748

Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Melzer D. Neighbourhood deprivation and incident mobility disability in older adults. Age Ageing. 2008 Jul;37(4):403-10. Epub 2008 May 16. 
PMID: 18487260

Steel N, Clark A, Lang IA, Wallace RB, Melzer D. Racial disparities in receipt of hip and knee joint replacements are not explained by need: the Health and Retirement Study 1998-2004. J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):629-34. 
PMID: 18559639

Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 2008 May 9;4(5):e1000072. 
PMID: 18464913

Freathy RM, Timpson NJ, Lawlor DA, Pouta A, Ben-Shlomo Y, et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.Diabetes. 2008 May;57(5):1419-26. Epub 2008 Mar 17. 
PMID: 18346983

Stevens KN, Lang IA, Guralnik JM, Melzer D. Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing. Age Ageing. 2008 May;37(3):300-5. Epub 2008 Feb 12. Erratum in: Age Ageing. 2009 Jan;38(1):134. Age Ageing. 2008 Sep;37(5):610. 
PMID: 18270246

Llewellyn DJ, Naughton F. Antipsychotic-induced weight gain in patients with schizophrenia. JAMA. 2008 Apr 23;299(16):1898-9; author reply 1899-900. 
PMID: 18430905

Llewellyn DJ, Lang IA, Xie J, Huppert FA, Melzer D, Langa KM. Framingham Stroke Risk Profile and poor cognitive function: a population-based study. BMC Neurol. 2008 Apr 22;8:12. 
PMID: 18430227

Melzer D. Genetic polymorphisms and human aging: association studies deliver. Rejuvenation Res. 2008 Apr;11(2):523-6. 
PMID: 18341427

Melzer D, Hogarth S, Liddell K, Ling T, Sanderson S, Zimmern RL. Genetic tests for common diseases: new insights, old concerns. BMJ. 2008 Mar 15;336(7644):590-3. 
PMID: 18340074

Lang IA, Llewellyn DJ, Langa KM, Wallace RB, Huppert FA, Melzer D. Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing.  J Am Geriatr Soc. 2008 Feb;56(2):191-8. Epub 2007 Dec 24. 
PMID: 18179489

Hogarth S, Javitt G, Melzer D. The current landscape for direct-to-consumer genetic testing: legal, ethical, and policy issues. Annu Rev Genomics Hum Genet. 2008;9:161-82. 
PMID: 18767961

Llewellyn DJ. The psychology of risk taking: toward the integration of psychometric and neuropsychological paradigms. Am J Psychol. 2008 Fall;121(3):363-76. Review. 
PMID: 18792715

2007

Lang IA, Guralnik JM, Melzer D. Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weight. J Am Geriatr Soc. 2007 Nov;55(11):1836-41. 
PMID: 17979901

Lang IA, Rice NE, Wallace RB, Guralnik JM, Melzer D. Smoking cessation and transition into retirement: analyses from the English Longitudinal Study of Ageing. Age Ageing. 2007 Nov;36(6):638-43. Epub 2007 Sep 28. 
PMID: 17906305

Rafiq S, Frayling TM, Murray A, Hurst A, Stevens K, Weedon MN, Henley W, Ferrucci L, Bandinelli S, Corsi AM, Guralnik JM, Melzer D. A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun. 2007 Oct;8(7):552-9. Epub 2007 Aug 2. 
PMID: 17671508

Lang I, Gardener E, Huppert FA, Melzer D. Was John Reid right? Smoking, class, and pleasure: a population-based cohort study in England. Public Health. 2007 Jul;121(7):518-24. Epub 2007 Mar 2.
PMID: 17337283

Rafiq S, Stevens K, Hurst AJ, Murray A, Henley W, Weedon MN, Bandinelli S, Corsi AM, Guralnik JM, Ferruci L, Melzer D, Frayling TM. Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels. Genes Immun. 2007 Jun;8(4):344-51. Epub 2007 Apr 19.
PMID: 17443229

Melzer D, Frayling TM, Murray A, Hurst AJ, Harries LW, et al. A common variant of the p16(INK4a) genetic region is associated with physical function in older people. Mech Ageing Dev. 2007 May-Jun;128(5-6):370-7. Epub 2007 Mar 27. 
PMID: 17459456

Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.Science. 2007 May 11;316(5826):889-94. Epub 2007 Apr 12. 
PMID: 17434869

Lang I, Wallace RB, Huppert FA, Melzer D. Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence. Age Ageing. 2007 May;36(3):256-61. Epub 2007 Mar 12. 
PMID: 17353234

Jagger C, Matthews R, Melzer D, Matthews F, Brayne C; MRC CFAS. Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS). Int J Epidemiol. 2007 Apr;36(2):358-65. Epub 2007 Jan 25. 
PMID: 17255347

Melzer D, Hurst AJ, Frayling T. Genetic variation and human aging: progress and prospects. J Gerontol A Biol Sci Med Sci. 2007 Mar;62(3):301-7. 
PMID: 17389728

Frayling TM, Rafiq S, Murray A, Hurst AJ, Weedon MN, Henley W, Bandinelli S, Corsi AM, Ferrucci L, Guralnik JM, Wallace RB, Melzer D. An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people. J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):73-8. 
PMID: 17301041

Lang I, Guralnik J, Wallace RB, Melzer D. What level of alcohol consumption is hazardous for older people? Functioning and mortality in U.S. and English national cohorts. J Am Geriatr Soc. 2007 Jan;55(1):49-57. 
PMID: 17233685

Hogarth S, Liddell K, Ling T, Sanderson S, Zimmern R, Melzer D. Closing the gaps--enhancing the regulation of genetic tests using responsive regulation. Food Drug Law J. 2007;62(4):831-48. 
PMID: 18557232