Promoting healthy ageing using C. elegans
C. elegans is a small (1 mm) worm that offers several practical and scientific advantages that make it an excellent model of human ageing, and of muscle health.
Using a range of genetic and molecular techniques, our lab uses C. elegans in several research projects, including:
- High-throughput screen of novel drug compounds using our new microfluidic culturing device, the NemaLife (in collaboration with Prof. Siva Vanapalli, Texas Tech University, US).
- Establishing the efficacy and mechanisms of mitochondrial hydrogen sulfide for improving health across the lifespan.
- Investigating novel therapeutics for primary mitochondrial diseases.
- Examining the causes of and new therapeutics for Duchenne Muscular Dystrophy.
Funded by the Biotechnology and Biological Sciences Research Council, the US Army, the United Mitochondrial Disease Foundation and the Northcott Devon Medical Foundation.