Publications by category
Journal articles
Reynolds JNJ, Avvisati R, Dodson PD, Fisher SD, Oswald MJ, Wickens JR, Zhang Y-F (2022). Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum.
Nature Communications,
13(1).
Abstract:
Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum
AbstractDopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny projection neurons (SPNs). Since phasic dopamine activity also encodes other behavioural variables, it is unclear how postsynaptic neurons identify which dopamine event is to induce long-term plasticity. Additionally, it is unknown how phasic dopamine released from arborised axons can potentiate targeted striatal synapses through volume transmission. To examine these questions we manipulated striatal cholinergic interneurons (ChIs) and dopamine neurons independently in two distinct in vivo paradigms. We report that long-term potentiation (LTP) at corticostriatal synapses with SPNs is dependent on the coincidence of pauses in ChIs and phasic dopamine activation, critically accompanied by SPN depolarisation. Thus, the ChI pause defines the time window for phasic dopamine to induce plasticity, while depolarisation of SPNs constrains the synapses eligible for plasticity.
Abstract.
Zhang Y-F, Cragg SJ (2021). Revisiting dopamine-acetylcholine imbalance in Parkinson’s disease: Glutamate co-transmission as an exciting partner in crime. Neuron, 109(7), 1070-1071.
Hitier M, Zhang Y-F, Sato G, Besnard S, Zheng Y, Smith PF (2021). Stratification of hippocampal electrophysiological activation evoked by selective electrical stimulation of different angular and linear acceleration sensors in the rat peripheral vestibular system. Hearing Research, 403, 108173-108173.
Hitier M, Zhang Y-F, Sato G, Besnard S, Zheng Y, Smith PF (2020). The effects of selective electrical stimulation of the rat cochlea on hippocampal field potentials. Hearing Research, 395, 108023-108023.
Condon MD, Platt NJ, Zhang Y-F, Roberts BM, Clements MA, Vietti-Michelina S, Tseu M-Y, Brimblecombe KR, Threlfell S, Mann EO, et al (2019). Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
Nature Communications,
10(1).
Abstract:
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter
AbstractMesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing release probability and axonal activity in determining short‐term plasticity of dopamine release, using fast‐scan cyclic voltammetry in the ex vivo mouse striatum. We show that brief short‐term facilitation and longer short term depression are only weakly dependent on the level of initial release, i.e. are release insensitive. Rather, short-term plasticity is strongly determined by mechanisms which govern axonal activation, including K+‐gated excitability and the dopamine transporter, particularly in the dorsal striatum. We identify the dopamine transporter as a master regulator of dopamine short‐term plasticity, governing the balance between release‐dependent and independent mechanisms that also show region‐specific gating.
Abstract.
Hitier M, Sato G, Zhang Y-F, Besnard S, Smith PF (2018). Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus. Neuroscience Letters, 677, 60-64.
Zhang Y-F, Reynolds JNJ, Cragg SJ (2018). Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron, 98(5), 918-925.e3.
Hitier M, Sato G, Zhang Y-F, Zheng Y, Besnard S, Smith PF (2018). Vestibular-related eye movements in the rat following selective electrical stimulation of the vestibular sensors. Journal of Comparative Physiology A, 204(9-10), 835-847.
Zhang Y-F, Cragg SJ (2017). Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations?. Frontiers in Systems Neuroscience, 11
Hitier M, Sato G, Zhang Y-F, Zheng Y, Besnard S, Smith PF, Curthoys IS (2016). Anatomy and surgical approach of rat’s vestibular sensors and nerves. Journal of Neuroscience Methods, 270, 1-8.
Kosillo P, Zhang Y-F, Threlfell S, Cragg SJ (2016). Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cerebral Cortex, 26(11), 4160-4169.
Publications by year
2022
Reynolds JNJ, Avvisati R, Dodson PD, Fisher SD, Oswald MJ, Wickens JR, Zhang Y-F (2022). Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum.
Nature Communications,
13(1).
Abstract:
Coincidence of cholinergic pauses, dopaminergic activation and depolarisation of spiny projection neurons drives synaptic plasticity in the striatum
AbstractDopamine-dependent long-term plasticity is believed to be a cellular mechanism underlying reinforcement learning. In response to reward and reward-predicting cues, phasic dopamine activity potentiates the efficacy of corticostriatal synapses on spiny projection neurons (SPNs). Since phasic dopamine activity also encodes other behavioural variables, it is unclear how postsynaptic neurons identify which dopamine event is to induce long-term plasticity. Additionally, it is unknown how phasic dopamine released from arborised axons can potentiate targeted striatal synapses through volume transmission. To examine these questions we manipulated striatal cholinergic interneurons (ChIs) and dopamine neurons independently in two distinct in vivo paradigms. We report that long-term potentiation (LTP) at corticostriatal synapses with SPNs is dependent on the coincidence of pauses in ChIs and phasic dopamine activation, critically accompanied by SPN depolarisation. Thus, the ChI pause defines the time window for phasic dopamine to induce plasticity, while depolarisation of SPNs constrains the synapses eligible for plasticity.
Abstract.
2021
Zhang Y-F, Cragg SJ (2021). Revisiting dopamine-acetylcholine imbalance in Parkinson’s disease: Glutamate co-transmission as an exciting partner in crime. Neuron, 109(7), 1070-1071.
Hitier M, Zhang Y-F, Sato G, Besnard S, Zheng Y, Smith PF (2021). Stratification of hippocampal electrophysiological activation evoked by selective electrical stimulation of different angular and linear acceleration sensors in the rat peripheral vestibular system. Hearing Research, 403, 108173-108173.
2020
Hitier M, Zhang Y-F, Sato G, Besnard S, Zheng Y, Smith PF (2020). The effects of selective electrical stimulation of the rat cochlea on hippocampal field potentials. Hearing Research, 395, 108023-108023.
2019
Condon MD, Platt NJ, Zhang Y-F, Roberts BM, Clements MA, Vietti-Michelina S, Tseu M-Y, Brimblecombe KR, Threlfell S, Mann EO, et al (2019). Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter.
Nature Communications,
10(1).
Abstract:
Plasticity in striatal dopamine release is governed by release-independent depression and the dopamine transporter
AbstractMesostriatal dopaminergic neurons possess extensively branched axonal arbours. Whether action potentials are converted to dopamine output in the striatum will be influenced dynamically and critically by axonal properties and mechanisms that are poorly understood. Here, we address the roles for mechanisms governing release probability and axonal activity in determining short‐term plasticity of dopamine release, using fast‐scan cyclic voltammetry in the ex vivo mouse striatum. We show that brief short‐term facilitation and longer short term depression are only weakly dependent on the level of initial release, i.e. are release insensitive. Rather, short-term plasticity is strongly determined by mechanisms which govern axonal activation, including K+‐gated excitability and the dopamine transporter, particularly in the dorsal striatum. We identify the dopamine transporter as a master regulator of dopamine short‐term plasticity, governing the balance between release‐dependent and independent mechanisms that also show region‐specific gating.
Abstract.
2018
Hitier M, Sato G, Zhang Y-F, Besnard S, Smith PF (2018). Effects of electrical stimulation of the rat vestibular labyrinth on c-Fos expression in the hippocampus. Neuroscience Letters, 677, 60-64.
Zhang Y-F, Reynolds JNJ, Cragg SJ (2018). Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine Modulation. Neuron, 98(5), 918-925.e3.
Hitier M, Sato G, Zhang Y-F, Zheng Y, Besnard S, Smith PF (2018). Vestibular-related eye movements in the rat following selective electrical stimulation of the vestibular sensors. Journal of Comparative Physiology A, 204(9-10), 835-847.
2017
Zhang Y-F, Cragg SJ (2017). Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations?. Frontiers in Systems Neuroscience, 11
2016
Hitier M, Sato G, Zhang Y-F, Zheng Y, Besnard S, Smith PF, Curthoys IS (2016). Anatomy and surgical approach of rat’s vestibular sensors and nerves. Journal of Neuroscience Methods, 270, 1-8.
Kosillo P, Zhang Y-F, Threlfell S, Cragg SJ (2016). Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cerebral Cortex, 26(11), 4160-4169.
