Rupert Payne
Professor of Primary Care and Clinical Pharmacology
R.A.Payne@exeter.ac.uk
5705
Smeall building JS105
Smeall Building, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK
Overview
Rupert Payne is a senior academic GP and clinical pharmacologist. He undertook his medical training and PhD in Edinburgh, and subsequently held a NIHR clinical lectureship in Cambridge and clinical senior lecturer position in Bristol.
He leads a programme of applied health service research focused on improving the safety and quality of medication use in primary car. He has a particular interest in improving how we measure, evaluate and manage polypharmacy, and has methodological expertise in pharmacoepidemiology, electronic health records, and data science. He is an active member of the Exeter Collaboration for Academic Primary Care (APEx).
He is co-Chair of the Society of Academic Primary Care, and practises clinically as a GP in North Somerset.
Qualifications
- MBChB (Edin)
- PhD (Edin)
- MRCGP
- FRCPE
- FBPhS
- FHEA
Links
Research
Research interests
Rupert leads a programme of applied health service research focused on improving the safety and quality of medicines use in primary care. He has worked with a wide range of quantitative and qualitative methodologies, and has particular expertise in pharmacoepidemiology, electronic health records, and data science.
Rupert has a particular interest in improving how we measure, evaluate and manage polypharmacy. He co-authored an influential King’s Fund report on this subject, and chaired the Research and Evidence section of the recent Department of Health National Overprescribing Review. He currently leads a large NIHR-funded clinical trial (IMPPP) evaluating a complex intervention for improving the management of polypharmacy, combining pharmacist-led structure medication review, collaborative working, informatics and approaches to increase clinician engagement. Rupert is also currently developing a novel Inappropriate Polypharmacy Score to address limitations in current approaches to assessing polypharmacy.
Rupert recently led development of the Cambridge Multimorbidity Score, an increasingly widely used tool for quantifying multimorbidity using routine health records, as well as the Bristol Medication Review model, which outlines a flexible, patient-centred approach to structured medication review. He has also published on a range of other topics related to medications and health services, including deprescribing, pharmacovigilance, sustainability, continuity of care, multimorbidity, and cardiovascular disease.
Publications
Journal articles
Payne RA (2024). Polypharmacy and deprescribing. Medicine (United Kingdom), 52(1), 36-39. Abstract.
Alexander GC, Budnitz D, Hughes C, Maas R, Mair A, McDonald EG, Meid AD, Payne R, Seidling HM, Shakir S, et al (2024). Proceedings of the International Ambulatory Drug Safety Symposium: Munich, Germany, June 2023. Drug Saf, 47(1), 103-111. Author URL.
Heuvelman H, Davies NM, Ben-Shlomo Y, Emond A, Evans J, Gunnell D, Liebling R, Morris R, Payne R, Storey C, et al (2023). Antidepressants in pregnancy: applying causal epidemiological methods to understand service-use outcomes in women and long-term neurodevelopmental outcomes in exposed children. Health Technol Assess, 27(15), 1-83. Abstract. Author URL.
North T-L, Harrison S, Bishop DC, Wootton RE, Carter AR, Richardson TG, Payne RA, Salisbury C, Howe LD (2023). Educational inequality in multimorbidity: causality and causal pathways. A mendelian randomisation study in UK Biobank. BMC Public Health, 23(1). Abstract. Author URL.
Edwards PJ, Sellers GM, Leach I, Holt L, Ridd MJ, Payne RA, Barnes RK (2023). Ideas, concerns, expectations, and effects on life (ICEE) in GP consultations: an observational study using video-recorded UK consultations. BJGP Open, 7(4). Abstract. Author URL.
Wade J, Humphrys E, Realpe AX, Gaunt DM, Burt J, Sheppard JP, Lown M, Temple E, Lowe R, Fraser R, et al (2023). Informed consent in randomised controlled trials: further development and evaluation of the participatory and informed consent (PIC) measure. Trials, 24(1). Abstract.
Davies J, Read J, Kruger D, Crisp N, Lamb N, Dixon M, Everington S, Hollins S, Moncrieff J, Giurca BC, et al (2023). Politicians, experts, and patient representatives call for the UK government to reverse the rate of antidepressant prescribing. BMJ, 383 Author URL.
Koshiaris C, Archer L, Lay-Flurrie S, Snell KI, Riley RD, Stevens R, Banerjee A, Usher-Smith JA, Clegg A, Payne RA, et al (2023). Predicting the risk of acute kidney injury: Derivation and validation of STRATIFY-AKI. British Journal of General Practice, 73(733).
Sheppard J, Koshiaris C, Stevens R, Lay-Flurrie S, Banerjee A, Bellows B, Clegg A, Hobbs R, Payne R, Swain S, et al (2023). THE ASSOCIATION BETWEEN ANTIHYPERTENSIVE TREATMENT AND SERIOUS ADVERSE EVENTS BY PREVIOUS HISTORY OF ADVERSE EVENTS: AN OBSERVATIONAL COHORT STUDY. Journal of Hypertension, 41(Suppl 3).
Sheppard JP, Koshiaris C, Stevens R, Lay-Flurrie S, Banerjee A, Bellows BK, Clegg A, Hobbs FDR, Payne RA, Swain S, et al (2023). The association between antihypertensive treatment and serious adverse events by age and frailty: a cohort study. PLoS medicine, 20(4). Abstract.
Hodkinson A, Zghebi SS, Kontopantelis E, Grigoroglou C, Ashcroft DM, Hann M, Chew-Graham CA, Payne RA, Little P, de Lusignan S, et al (2023). The association of strong opioids and antibiotics prescribing with general practitioner burnout. British Journal of General Practice, 73(733).
Naughton M, Payne RA (2023). The fight against climate change in primary care: a prescription for change. Fam Pract, 40(3), 508-510. Author URL.
McDonagh S, Cross R, Masoli J, Konya J, Abel G, Sheppard J, Jakubowski B, Bhanu C, Fordham J, Turner K, et al (2023). UNDERSTANDING MEASUREMENT OF POSTURAL HYPOTENSION: a NATIONWIDE SURVEY OF PRIMARY CARE PRACTICE IN ENGLAND. Journal of Hypertension, 41(Suppl 3).
Clark C, McDonagh S, Cross R, Masoli J, Konya J, Abel G, Sheppard J, Jakubowski B, Bhanu C, Fordham J, et al (2023). Understanding Measurement of postural hypotension: a nationwide survey of primary care practice in England. Br J Gen Pract, 73(suppl 1). Abstract. Author URL.
Winn E, Kissane M, Merriel SW, Brain T, Silverwood VA, Whitehead IO, Howe LD, Payne RA, Duncan P, Primary Care Academic Collaborative (PACT), et al (2023). Using the Primary care Academic CollaboraTive to explore the characteristics and healthcare use of older housebound patients in England: protocol for a retrospective observational study and clinician survey (the CHiP study). BJGP Open, 7(4). Abstract. Author URL.
Bansal N, Hudda M, Payne RA, Smith DJ, Kessler D, Wiles N (2022). Antidepressant use and risk of adverse outcomes: population-based cohort study. BJPsych Open, 8(5). Abstract. Author URL.
Tammes P, Payne RA, Salisbury C (2022). Association between continuity of primary care and both prescribing and adherence of common cardiovascular medications: a cohort study among patients in England. BMJ Open, 12(9). Abstract.
Oliver-Williams C, Stevens D, Payne RA, Wilkinson IB, Smith GCS, Wood A (2022). Association between hypertensive disorders of pregnancy and later risk of cardiovascular outcomes. BMC Med, 20(1). Abstract. Author URL.
Thygesen JH, Tomlinson C, Hollings S, Mizani MA, Handy A, Akbari A, Banerjee A, Cooper J, Lai AG, Li K, et al (2022). COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records. The Lancet Digital Health, 4(7), e542-e557. Abstract.
Jowett S, Kodabuckus S, Ford GA, Hobbs FDR, Lown M, Mant J, Payne R, McManus RJ, Sheppard JP, OPTiMISE investigators, et al (2022). Cost-Effectiveness of Antihypertensive Deprescribing in Primary Care: a Markov Modelling Study Using Data from the OPTiMISE Trial. Hypertension, 79(5), 1122-1131. Abstract. Author URL.
Archer L, Koshiaris C, Lay-Flurrie S, Snell KIE, Riley RD, Stevens R, Banerjee A, Usher-Smith JA, Clegg A, Payne RA, et al (2022). Development and external validation of a risk prediction model for falls in patients with an indication for antihypertensive treatment: retrospective cohort study. BMJ, 379 Abstract. Author URL.
Payne RA, Blair PS, Caddick B, Chew-Graham CA, Dreischulte T, Duncan LJ, Guthrie B, Mann C, Parslow RM, Round J, et al (2022). Improving Medicines use in People with Polypharmacy in Primary Care (IMPPP): Protocol for a multicentre cluster randomised trial comparing a complex intervention for medication optimization against usual care. NIHR Open Research, 2, 54-54. Abstract.
Payne RA, Blair PS, Caddick B, Chew-Graham CA, Dreischulte T, Duncan LJ, Guthrie B, Mann C, Parslow RM, Round J, et al (2022). Improving Medicines use in People with Polypharmacy in Primary Care (IMPPP): Protocol for a multicentre cluster randomised trial comparing a complex intervention for medication optimization against usual care. NIHR open research, 2 Abstract.
Zhou AY, Zghebi SS, Hodkinson A, Hann M, Grigoroglou C, Ashcroft DM, Esmail A, Chew-Graham CA, Payne R, Little P, et al (2022). Investigating the links between diagnostic uncertainty, emotional exhaustion, and turnover intention in General Practitioners working in the United Kingdom. Front Psychiatry, 13 Abstract. Author URL.
Culeddu G, Su L, Cheng Y, Pereira DIA, Payne RA, Powell JJ, Hughes DA (2022). Novel oral iron therapy for iron deficiency anaemia: How to value safety in a new drug?. British Journal of Clinical Pharmacology, 88(3), 1347-1357. Abstract.
McCahon D, Duncan P, Payne R, Horwood J (2022). Patient perceptions and experiences of medication review: qualitative study in general practice. BMC Prim Care, 23(1). Abstract. Author URL.
Scott L, Redaniel MT, Booker M, Payne RA, Tilling K (2022). Regression discontinuity analysis for pharmacovigilance: statin example reflected trial findings showing little evidence of harm. Journal of Clinical Epidemiology, 141, 121-131. Abstract.
Fisk M, Zecharia A, Payne R, Okorie M, Alexander S, Baker E, Cremers S (2022). Sustainable medicines development and use: Our collective responsibility for action to mitigate the natural world crisis. Br J Clin Pharmacol, 88(7), 3013-3015. Author URL.
Fellenor J, Britten N, Courtenay M, Payne RA, Valderas J, Denholm R, Duncan P, McCahon D, Tatnell L, Fitzgerald R, et al (2021). A multi-stakeholder approach to the co-production of the research agenda for medicines optimisation. BMC Health Services Research, 21(1). Abstract.
Albasri A, Hattle M, Koshiaris C, Dunnigan A, Paxton B, Fox SE, Smith M, Archer L, Levis B, Payne RA, et al (2021). Association between antihypertensive treatment and adverse events: systematic review and meta-analysis. The BMJ, 372 Abstract.
Hamilton F, Arnold D, Payne R (2021). Association of prior lymphopenia with mortality in pneumonia: a cohort study in UK primary care. Br J Gen Pract, 71(703), e148-e156. Abstract. Author URL.
Sheppard JP, Lown M, Burt J, Ford GA, Hobbs FDR, Little P, Mant J, Payne RA, McManus RJ (2021). Blood Pressure Changes Following Antihypertensive Medication Reduction, by Drug Class and Dose Chosen for Withdrawal: Exploratory Analysis of Data from the OPTiMISE Trial. Frontiers in Pharmacology, 12 Abstract.
McCahon D, Denholm RE, Huntley AL, Dawson S, Duncan P, Payne RA (2021). Development of a model of medication review for use in clinical practice: Bristol medication review model. BMC Medicine, 19(1). Abstract.
Arnold DT, Hamilton FW, Morris TT, Suri T, Morley A, Frost V, Vipond IB, Medford AR, Payne RA, Muir P, et al (2021). Epidemiology of pleural empyema in English hospitals and the impact of influenza. European Respiratory Journal, 57(6). Abstract.
Kuberska K, Scheibl F, Sinnott C, Sheppard JP, Lown M, Williams M, Payne RA, Mant J, McManus RJ, Burt J, et al (2021). GPs' mindlines on deprescribing antihypertensives in older patients with multimorbidity: a qualitative study in English general practice. British Journal of General Practice, 71(708), E498-E507. Abstract.
Hayward S, Hole B, Denholm R, Duncan P, Morris JE, Fraser SDS, Payne RA, Roderick P, Chesnaye NC, Wanner C, et al (2021). International prescribing patterns and polypharmacy in older people with advanced chronic kidney disease: Results from the European Quality study. Nephrology Dialysis Transplantation, 36(3), 503-511. Abstract.
Gangannagaripalli J, Porter I, Davey A, Ricci Cabello I, Greenhalgh J, Anderson R, Briscoe S, Hughes C, Payne R, Cockcroft E, et al (2021). STOPP/START interventions to improve medicines management for people aged 65 years and over: a realist synthesis. Health Services and Delivery Research, 9(23), 1-118. Abstract.
Walker L, Bennett F, Scourfield A, Payne R (2021). The future of clinical pharmacology in the NHS. Prescriber, 32(2), 20-23.
Dambha-Miller H, Griffin SJ, Young D, Watkinson P, Tan PS, Clift AK, Payne RA, Coupland C, Hopewell JC, Mant J, et al (2021). The use of primary care big data in understanding the pharmacoepidemiology of COVID-19: a consensus statement from the COVID-19 primary care database consortium. Annals of Family Medicine, 19(2), 135-140. Abstract.
Duncan P, Payne RA, Merriel S (2020). A new collaborative model of primary care research: could it provide trainees and clinicians with more opportunities to get involved?. British Journal of General Practice, 70(698), 430-431.
Hamilton F, Arnold D, Henley W, Payne RA (2020). Aspirin reduces cardiovascular events in patients with pneumonia: a prior event rate ratio analysis in a large primary care database. European Respiratory Journal, 57(2), 2002795-2002795. Abstract.
Zhu Y, Edwards D, Mant J, Payne RA, Kiddle S (2020). Characteristics, service use and mortality of clusters of multimorbid patients in England: a population-based study. BMC Medicine, 18(1). Abstract.
Sheppard JP, Payne RA (2020). Deprescribing antihypertensives in patients with multimorbidity. Prescriber, 31(10), 16-19.
Payne RA, Mendonca SC, Elliott MN, Saunders CL, Edwards DA, Marshall M, Roland M (2020). Development and validation of the Cambridge Multimorbidity Score. CMAJ, 192(5), E107-E114. Abstract.
Harshfield A, Abel GA, Barclay S, Payne RA (2020). Do GPs accurately record date of death? a UK observational analysis. BMJ Support Palliat Care, 10(3). Abstract. Author URL.
Sheppard JP, Burt J, Lown M, Temple E, Lowe R, Fraser R, Allen J, Ford GA, Heneghan C, Hobbs FDR, et al (2020). Effect of Antihypertensive Medication Reduction vs Usual Care on Short-term Blood Pressure Control in Patients with Hypertension Aged 80 Years and Older: the OPTIMISE Randomized Clinical Trial. JAMA - Journal of the American Medical Association, 323(20), 2039-2051. Abstract.
Sheppard JP, Lown M, Burt J, Temple E, Lowe R, Ashby H, Todd O, Allen J, Ford GA, Fraser R, et al (2020). Generalizability of Blood Pressure Lowering Trials to Older Patients: Cross-Sectional Analysis. J Am Geriatr Soc, 68(11), 2508-2515. Abstract. Author URL.
Denholm R, Morris R, Purdy S, Payne R (2020). Impact of emergency hospital admissions on patterns of primary care prescribing: a retrospective cohort analysis of electronic records in England. Br J Gen Pract, 70(695), e399-e405. Abstract. Author URL.
Payne RA (2020). Polypharmacy and deprescribing. Medicine (United Kingdom), 48(7), 468-471. Abstract.
Denholm R, Thom H, Hollingworth W, Payne R (2020). Uptake of direct oral anticoagulants in primary care: an ecological and economic study. BJGP Open, 4(2). Abstract.
Denholm R, Thom H, Hollingworth W, Payne R (2020). Uptake of direct oral anticoagulants in primary care: an ecological and economic study. BJGP Open, 4(2). Abstract. Author URL.
Zhu Y, Edwards D, Kiddle S, Payne R (2019). Characteristics and outcomes of clusters of multimorbid patients in UK general practice. European Journal of Public Health, 29(Supplement_4).
Morton K, MacNeill S, Sanderson E, Dixon P, King A, Jenkins S, Metcalfe C, Shaw A, Chalder M, Benger J, et al (2019). Evaluation of 'care bundles' for patients with chronic obstructive pulmonary disease (COPD): a multisite study in the UK. BMJ Open Respir Res, 6(1). Abstract. Author URL.
Sheppard J, Burt J, Lown M, Temple E, Lowe R, Todd O, Ford G, Hobbs FDR, Little P, Mant J, et al (2019). P2649Do these data apply to me? Examining the applicability of trials assessing strategies for optimal management of blood pressure to older patients in UK primary care. European Heart Journal, 40(Supplement_1).
Denholm R, Morris R, Payne R (2019). Polypharmacy patterns in the last year of life in patients with dementia. Eur J Clin Pharmacol, 75(11), 1583-1591. Abstract. Author URL.
Tammes P, Payne RA, Salisbury C, Chalder M, Purdy S, Morris RW (2019). The impact of a named GP scheme on continuity of care and emergency hospital admission: a cohort study among older patients in England, 2012-2016. BMJ Open, 9(9). Abstract. Author URL.
Linton MJ, Jones T, Owen-Smith A, Payne RA, Coast J, Glynn J, Hollingworth W (2018). Breaking bread: Examining the impact of policy changes in access to state-funded provisions of gluten-free foods in England. BMC Medicine, 16(1). Abstract.
Rhodes KM, Turner RM, Payne RA, White IR (2018). Computationally efficient methods for fitting mixed models to electronic health records data. Statistics in Medicine, 37(29), 4557-4570. Abstract.
Mossakowska TJ, Saunders CL, Corbett J, MacLure C, Winpenny EM, Dujso E, Payne RA (2018). Current and future cardiovascular disease risk assessment in the European Union: an international comparative study. European Journal of Public Health, 28(4), 748-754. Abstract.
Burt J, Elmore N, Campbell SM, Rodgers S, Avery AJ, Payne RA (2018). Developing a measure of polypharmacy appropriateness in primary care: Systematic review and expert consensus study. BMC Medicine, 16(1). Abstract.
King S, Miani C, Exley J, Larkin J, Kirtley A, Payne RA (2018). Impact of issuing longer- versus shorter-duration prescriptions: a systematic review. British Journal of General Practice, 68(669), e286-e292. Abstract.
Martin A, Payne R, Wilson EC (2018). Long-Term Costs and Health Consequences of Issuing Shorter Duration Prescriptions for Patients with Chronic Health Conditions in the English NHS. Appl Health Econ Health Policy, 16(3), 317-330. Abstract. Author URL.
Sheppard JP, Burt J, Lown M, Temple E, Benson J, Ford GA, Heneghan C, Hobbs FDR, Jowett S, Little P, et al (2018). OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE): protocol for a randomised controlled non-inferiority trial. BMJ Open, 8(9). Abstract. Author URL.
Cherskov A, Pohl A, Allison C, Zhang H, Payne RA, Baron-Cohen S (2018). Polycystic ovary syndrome and autism: a test of the prenatal sex steroid theory. Translational Psychiatry, 8(1). Abstract.
Cassell A, Edwards D, Harshfield A, Rhodes K, Brimicombe J, Payne R, Griffin S (2018). The epidemiology of multimorbidity in primary care: a retrospective cohort study. Br J Gen Pract, 68(669), e245-e251. Abstract. Author URL.
Browne J, Edwards DA, Rhodes KM, Brimicombe DJ, Payne RA (2017). Association of comorbidity and health service usage among patients with dementia in the UK: a population-based study. BMJ Open, 7(3). Abstract.
Van Vugt VA, Van Der Horst HE, Payne RA, Maarsingh OR (2017). Chronic vertigo: Treat with exercise, not drugs. BMJ (Online), 358
Miani C, Martin A, Exley J, Doble B, Wilson E, Payne R, Avery A, Meads C, Kirtley A, Jones MM, et al (2017). Clinical effectiveness and cost-effectiveness of issuing longer versus shorter duration (3-month vs. 28-day) prescriptions in patients with chronic conditions: systematic review and economic modelling. Health Technol Assess, 21(78), 1-128. Abstract. Author URL.
Duncan P, Duerden M, Payne RA (2017). Deprescribing: a primary care perspective. European Journal of Hospital Pharmacy, 24(1), 37-42. Abstract.
Usher-Smith JA, Winther LR, Shefer GS, Silarova B, Payne RA, Griffin SJ (2017). Factors Associated with Engagement with a Web-Based Lifestyle Intervention Following Provision of Coronary Heart Disease Risk: Mixed Methods Study. J Med Internet Res, 19(10). Abstract. Author URL.
Wilson CL, Rhodes KM, Payne RA (2017). Financial incentives improve recognition but not treatment of cardiovascular risk factors in severe mental illness. PLoS ONE, 12(6). Abstract.
Doble B, Payne R, Harshfield A, Wilson ECF (2017). Retrospective, multicohort analysis of the Clinical Practice Research Datalink (CPRD) to determine differences in the cost of medication wastage, dispensing fees and prescriber time of issuing either short (<60 days) or long (≥60 days) prescription lengths in primary care for common, chronic conditions in the UK. BMJ Open, 7(12). Abstract. Author URL.
Abel GA, Barclay ME, Payne RA (2016). Adjusted indices of multiple deprivation to enable comparisons within and between constituent countries of the UK including an illustration using mortality rates. BMJ Open, 6(11), e012750-e012750.
Payne RA (2016). The epidemiology of polypharmacy. Clinical Medicine, Journal of the Royal College of Physicians of London, 16(5), 465-469. Abstract.
Mercer SW, Payne RA, Nicholl BI, Morrison J (2015). Authors' reply to Lewis and Bray. BMJ (Online), 351
Paddison CA, Saunders CL, Abel GA, Payne RA, Adler AI, Graffy JP, Roland MO (2015). How do people with diabetes describe their experiences in primary care? Evidence from 85,760 patients with self-reported diabetes from the English General Practice Patient Survey. Diabetes Care, 38(3), 469-475. Abstract.
Sinnott C, Mercer SW, Payne RA, Duerden M, Bradley CP, Byrne M (2015). Improving medication management in multimorbidity: Development of the MultimorbiditY COllaborative Medication Review and DEcision Making (MY COMRADE) intervention using the Behaviour Change Wheel. Implementation Science, 10(1). Abstract.
Silarova B, Lucas J, Butterworth AS, Di Angelantonio E, Girling C, Lawrence K, Mackintosh S, Moore C, Payne RA, Sharp SJ, et al (2015). Information and Risk Modification Trial (INFORM): Design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour. BMC Public Health, 15(1). Abstract.
Payne R, Duerden M (2015). Polypharmacy - appropriate, problematic or both?. Prescriber, 26(4), 31-34. Abstract.
Mercer SW, Payne RA, Nicholl BI, Morrison J (2015). Risk of intracranial haemorrhage linked to co-Treatment with antidepressants and NSAIDs. BMJ (Online), 351
Paddison CAM, Saunders CL, Abel GA, Payne RA, Campbell JL, Roland M (2015). Why do patients with multimorbidity in England report worse experiences in primary care? Evidence from the General Practice Patient Survey. BMJ Open, 5(3). Abstract. Author URL.
Appleton SC, Abel GA, Payne RA (2014). Cardiovascular polypharmacy is not associated with unplanned hospitalisation: evidence from a retrospective cohort study. BMC Fam Pract, 15, 58-58. Abstract.
Mukherjee M, Gupta R, Farr A, Heaven M, Stoddart A, Nwaru BI, Fitzsimmons D, Chamberlain G, Bandyopadhyay A, Fischbacher C, et al (2014). Estimating the incidence, prevalence and true cost of asthma in the UK: secondary analysis of national stand-alone and linked databases in England, Northern Ireland, Scotland and Wales-a study protocol. BMJ Open, 4(11). Abstract. Author URL.
Payne RA, Abel GA, Avery AJ, Mercer SW, Roland MO (2014). Is polypharmacy always hazardous? a retrospective cohort analysis using linked electronic health records from primary and secondary care. Br J Clin Pharmacol, 77(6), 1073-1082. Abstract.
Payne RA, Avery AJ, Duerden M, Saunders CL, Simpson CR, Abel GA (2014). Prevalence of polypharmacy in a Scottish primary care population. Eur J Clin Pharmacol, 70(5), 575-581. Abstract.
Payne RA, Abel GA, Avery AJ, Mercer SW, Roland MO (2014). Response to: assessing the harms of polypharmacy requires careful interpretation and consistent definitions. Br J Clin Pharmacol, 78(3), 672-673.
Tomlinson LA, Abel GA, Chaudhry AN, Tomson CR, Wilkinson IB, Roland MO, Payne RA (2013). ACE inhibitor and angiotensin receptor-II antagonist prescribing and hospital admissions with acute kidney injury: a longitudinal ecological study. PLoS One, 8(11), e78465-e78465. Abstract.
Payne RA, Abel GA, Simpson CR, Maxwell SR (2013). Association between prescribing of cardiovascular and psychotropic medications and hospital admission for falls or fractures. Drugs Aging, 30(4), 247-254. Abstract.
Nagraj S, Abel G, Paddison C, Payne R, Elliott M, Campbell J, Roland M (2013). Changing practice as a quality indicator for primary care: Analysis of data on voluntary disenrollment from the English GP Patient Survey. BMC Family Practice, 14 Abstract.
Teoh WL, Price JF, Williamson RM, Payne RA, Van Look LAF, Reynolds RM (2013). Erratum: Metabolic parameters associatedwith arterial stiffness in older adults withType 2 diabetes: the edinburgh type 2 diabetes study (Journal of Hypertension (2013) 31 (1010-1017)). Journal of Hypertension, 31(7).
Payne RA, Webb DJ (2013). Letter by payne and webb regarding article, "agreement among cardiovascular disease risk calculators". Circulation, 128(21).
Teoh WL, Price JF, Williamson RM, Payne RA, Van Look LAF, Reynolds RM, Frier BM, Wilkinson IB, Webb DJ, Strachan MWJ, et al (2013). Metabolic parameters associated with arterial stiffness in older adults with Type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Journal of Hypertension, 31(5), 1010-1017. Abstract.
Tomlinson LA, Riding AM, Payne RA, Abel GA, Tomson CR, Wilkinson IB, Roland MO, Chaudhry AN (2013). The accuracy of diagnostic coding for acute kidney injury in England - a single centre study. BMC Nephrol, 14, 58-58. Abstract.
Payne RA, Abel GA, Guthrie B, Mercer SW (2013). The effect of physical multimorbidity, mental health conditions and socioeconomic deprivation on unplanned admissions to hospital: a retrospective cohort study. CMAJ, 185(5), E221-E228. Abstract.
Payne RA, Abel GA, Simpson CR (2012). A retrospective cohort study assessing patient characteristics and the incidence of cardiovascular disease using linked routine primary and secondary care data. BMJ Open, 2(2), e000723-e000723. Abstract.
Payne RA (2012). Cardiovascular risk. British Journal of Clinical Pharmacology, 74(3), 396-410. Abstract.
Tomlinson LA, Payne RA, Abel GA, Chaudhry AN, Tomson CR, Wilkinson IB, Roland MO (2012). Relation between national changes in prescription of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers and admissions with acute kidney injury. The Lancet, 380
Payne RA (2011). Augmentation index for stratifying progression of chronic kidney disease. American Journal of Hypertension, 24(7).
El Turabi A, Payne R (2011). Ethnicity and hypertension: not as black and white as NICE makes out. BMJ, 343 Author URL.
Payne RA, Avery AJ (2011). Polypharmacy: One of the greatest prescribing challenges in general practice. British Journal of General Practice, 61(583), 83-84.
Payne RA (2011). Prescribing safety: the case of inappropriate medicines. British Journal of General Practice, 61(590), 542-543.
Payne RA, Wilkinson IB, Webb DJ (2010). Arterial stiffness and hypertension: Emerging concepts. Hypertension, 55(1), 9-14.
Payne RA, Lilitkarntakul P, Dhaun N, Melville V, Asai T, Goddard J, Webb DJ (2010). Renal dysfunction does not affect the peripheral-to-central arterial pressure transfer function. Hypertension, 56(6), 1083-1088. Abstract.
Payne RA, Webb DJ, Maxwell SRJ (2009). Assessing cardiovascular risk. Correction and transparency of BNF risk charts. BMJ, 338 Author URL.
Payne RA (2009). Augmenting the assessment of marfan syndrome. American Journal of Hypertension, 22(9).
Payne RA, Maxwell SR (2009). Deprivation-based risk scores: the re-emergence of postcode prescribing in the UK?. J Cardiovasc Med (Hagerstown), 10(2), 157-160. Abstract. Author URL.
Payne RA, Oliver JJ, Bain M, Elders A, Bateman DN (2009). Patterns and predictors of re-admission to hospital with self-poisoning in Scotland. Public Health, 123(2), 134-137. Abstract. Author URL.
Payne RA, Webb DJ (2008). Peripheral augmentation index: Shouldering the central pressure load. Hypertension, 51(1), 37-38.
Payne RA, Teh CH, Webb DJ, Maxwell SRJ (2007). A generalized arterial transfer function derived at rest underestimates augmentation of central pressure after exercise. Journal of Hypertension, 25(11), 2266-2272. Abstract.
Payne RA, Hilling-Smith RC, Webb DJ, Maxwell SR, Denvir MA (2007). Augmentation index assessed by applanation tonometry is elevated in Marfan syndrome. Journal of Cardiothoracic Surgery, 2(1). Abstract.
Payne RA, Isnardi D, Andrews PJD, Maxwell SRJ, Webb DJ (2007). Similarity between the suprasystolic wideband external pulse wave and the first derivative of the intra-arterial pulse wave. British Journal of Anaesthesia, 99(5), 653-661. Abstract.
Payne RA, Webb DJ (2006). Arterial blood pressure and stiffness in hypertension: is arterial structure important?. Hypertension, 48(3), 366-367.
Payne RA, Symeonides CN, Webb DJ, Maxwell SRJ (2006). Pulse transit time measured from the ECG: an unreliable marker of beat-to-beat blood pressure. Journal of Applied Physiology, 100(1), 136-141. Abstract.
Maxwell SRJ, Payne RA, Murray GD, Webb DJ (2006). Selectivity of NSAIDs for COX-2 and cardiovascular outcome. British Journal of Clinical Pharmacology, 62(2), 243-245. Abstract.
Conferences
Sheppard J, Lown M, Burt J, Temple E, Ford G, Hobbs R, Little P, Mant J, Payne R, McManus R, et al (2021). OPTIMAL DRUGS FOR MEDICATION REDUCTION: SECONDARY ANALYSIS OF THE OPTIMISE MEDICATION REDUCTION TRIAL. Author URL.
Sheppard J, Burt J, Lown M, Temple E, Lowe R, Fraser R, Allen J, Ford G, Heneghan C, Hobbs R, et al (2021). SHORT-TERM SAFETY OF ANTIHYPERTENSIVE MEDICATION REDUCTION IN MULTI-MORBID PATIENTS WITH MILD HYPERTENSION: THE OPTIMISE RANDOMISED CONTROLLED NON-INFERIORITY TRIAL. Author URL.
Oliver-Williams C, Stevens D, Payne R, Wilkinson I, Smith G, Wood A (2019). ASSOCIATION BETWEEN HYPERTENSIVE DISORDERS OF PREGNANCY AND LATER RISK OF CARDIOVASCULAR OUTCOMES. Author URL.
Zhu Y, Edwards D, Payne RA, Kiddle S (2019). Characteristics, service use, and mortality of clusters of multimorbid patients in England: a population-based study. Author URL.
Arnold D, Hamilton F, Morris T, Payne R, Maskell N (2019). S12 the changes in incidence and management of pleural empyema in England over the last decade. Pleural disease: not so benign.
Harshfield A, Payne R, Barclay S (2018). 93 Patterns of general practice prescribing in the last year of life. Poster presentations.
Silarova B, Sharp SJ, Usher-Smith JA, Lucas J, Payne RA, Shefer G, Moore C, Girling C, Lawrence K, Tolkien Z, et al (2016). Effect of Communicating Phenotypic and Genetic Risk of Coronary Heart Disease Alongside Web-based Lifestyle Advice - the Inform Randomized Clinical Trial. Author URL.
Bond S, Payne R, Wilson E, Chowdry A, Caskey F, Wheeler D, Hiemstra T (2015). Using the UK renal registry for a clinical trial in dialysis patients: the example of SIMPLIFIED. Author URL.
Payne RA, Symeonides CN, Webb DJ, Maxwell SR (2004). Pulse transit time measured from the ECG as a marker of exercise blood pressure. Author URL.
External Engagement and Impact
Committee/panel activities
- Co-chair, Society of Academic Primary Care
- Expert clinical advisor, Royal College of General Practitioners
- Member, MHRA Pharmacovigilance Expert Advisory Group
Editorial responsibilities
- Consultant Editor, Prescriber
- Associate Editor, British Journal of Clinical Pharmacology
