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 Mark Carew

Mark Carew

Lecturer in Biomedical Science (Education & Scholarship)

 College House G.03

 

College House, University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2LU, UK

Overview

Originally a cell biologist (calcium signaling), Mark’s post-doctoral research was at Cambridge (epithelial chloride transport) and the National Institute of Environmental Health Sciences in North Carolina (cystic fibrosis). He taught physiology and pharmacology at Kingston University for many years. His research, and that of his PhD students, was on a variety of topics including the anti-proliferative actions of phytochemicals. In between academic roles, he has worked in medical communications as a medical writer for pharmaceutical company clients

Qualifications

  • 2015 Senior Fellow of the Higher Education Academy
  • 2005 PGHCE, Kingston University
  • 1995 PhD, University of Cambridge
  • 1991 BSc (Hons), King’s College, University of London

Research

Research interests

Mark is actively engaged in a variety of educational research projects. His Microlearning Medical Sciences with Daily Questions research study seeks to evaluate the educational impact of daily tweet-sized questions to students learning pharmacology and other medical sciences.  He also supervises projects developing traditional card games to help students learn physiology and pharmacology.

Research projects

  • Microlearning Medical Sciences with Daily Questions (2022-23)

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Easa N, Alany RG, Carew M, Vangala A (2019). A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade. DRUG DISCOVERY TODAY, 24(2), 440-451. Author URL.
Carew M (2018). Using a word game to test physiology comprehension. ADVANCES IN PHYSIOLOGY EDUCATION, 42(3), 464-465. Author URL.
Aldhaher A, Langat M, Ndunda B, Chirchir D, Midiwo JO, Njue A, Schwikkard S, Carew M, Mulholland D (2017). Diterpenoids from the roots of Croton dichogamus Pax. PHYTOCHEMISTRY, 144, 1-8. Author URL.
Abdelkader H, Pierscionek B, Carew M, Wu Z, Alany RG (2015). Critical appraisal of alternative irritation models: three decades of testing ophthalmic pharmaceuticals. BRITISH MEDICAL BULLETIN, 113(1), 59-71. Author URL.
Waheed A, Ludtmann MHR, Pakes N, Robery S, Kuspa A, Dinh C, Baines D, Williams RSB, Carew MA (2014). Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 ( polycystin-2)dependent manner. BRITISH JOURNAL OF PHARMACOLOGY, 171(10), 2659-2670. Author URL.
Polycarpou E, Meira LB, Carrington S, Tyrrell E, Modjtahedi H, Carew MA (2013). Resveratrol 3-O-D-glucuronide and resveratrol 4 '-O-D-glucuronide inhibit colon cancer cell growth: Evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. MOLECULAR NUTRITION & FOOD RESEARCH, 57(10), 1708-1717. Author URL.
Waheed A, Barker J, Barton SJ, Owen CP, Ahmed S, Carew MA (2012). A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cells. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 47(2), 464-473. Author URL.
Young JS, Matharu R, Carew MA, Fry CH (2012). Inhibition of stretching-evoked ATP release from bladder mucosa by anticholinergic agents. BJU INTERNATIONAL, 110(8B), E397-E401. Author URL.
Tyrrell E, Brawn P, Carew M, Greenwood I (2011). An expedient conversion of alpha-amino acids into Weinreb amides using COMU (R) as a coupling agent. TETRAHEDRON LETTERS, 52(3), 369-372. Author URL.
Waheed A, Barker J, Barton SJ, Khan G-M, Najm-us-Saqib Q, Hussain M, Ahmed S, Owen C, Carew MA (2011). Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells. JOURNAL OF ETHNOPHARMACOLOGY, 137(3), 1189-1196. Author URL.
Ganbold M, Barker J, Ma R, Jones L, Carew M (2010). Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. J Ethnopharmacol, 131(2), 396-403. Abstract.  Author URL.
Ribeiro CMP, Paradiso AM, Carew MA, Shears SB, Boucher RC (2005). Cystic fibrosis airway epithelial Ca-i(2+) signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(11), 10202-10209. Author URL.
Ho MWY, Yang XN, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, et al (2002). Regulation of Ins(3,4,5,6)P-4 signaling by a reversible kinase/phosphatase. CURRENT BIOLOGY, 12(6), 477-482. Author URL.
Carew MA, Thorn P (2000). Carbachol-stimulated chloride secretion in mouse colon: evidence of a role for autocrine prostaglandin E-2 release. EXPERIMENTAL PHYSIOLOGY, 85(1), 67-72. Author URL.
Carew MA, Yang XN, Schultz C, Shears SB (2000). myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(35), 26906-26913. Author URL.
Yang X, Rudolf M, Carew MA, Yoshida M, Nerreter V, Riley AM, Chung SK, Bruzik KS, Potter BV, Schultz C, et al (1999). Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem, 274(27), 18973-18980. Abstract.  Author URL.
Ferguson AV, Bicknell RJ, Carew MA, Mason WT (1997). Dissociated adult rat subfornical organ neurons maintain membrane properties and angiotensin responsiveness for up to 6 days. NEUROENDOCRINOLOGY, 66(6), 409-415. Author URL.
Carew MA, Thorn P (1996). Identification of CIC-2-like chloride currents in pig pancreatic acinar cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 433(1-2), 84-90. Author URL.
CAREW MA, MASON WT (1995). CONTROL OF CA2+ ENTRY INTO RAT LACTOTROPHS BY THYROTROPIN-RELEASING-HORMONE. JOURNAL OF PHYSIOLOGY-LONDON, 486(2), 349-360. Author URL.
CAREW MA, WU ML, LAW GJ, TSENG YZ, MASON WT (1994). EXTRACELLULAR ATP ACTIVATES CALCIUM-ENTRY AND MOBILIZATION VIA P-2U-PURINOCEPTORS IN RAT LACTOTROPHS. CELL CALCIUM, 16(3), 227-235. Author URL.
CAREW MA, PALEOLOG EM, PEARSON JD (1992). THE ROLES OF PROTEIN-KINASE-C AND INTRACELLULAR CA2+ IN THE SECRETION OF VONWILLEBRAND-FACTOR FROM HUMAN VASCULAR ENDOTHELIAL-CELLS. BIOCHEMICAL JOURNAL, 286, 631-635. Author URL.
PALEOLOG EM, CAREW MA, PEARSON JD (1991). EFFECTS OF TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 ON VONWILLEBRAND-FACTOR SECRETION FROM HUMAN VASCULAR ENDOTHELIAL-CELLS. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 60(1-2), 279-285. Author URL.

Conferences

Carew MA, Ermolayeva E, Goddard CA, Thorn P (1998). PGE(2) release from unstimulated epithelial cells of the mouse descending colon is an autocrine regulator of cellular cAMP.  Author URL.
Carew MA, Thorn P (1996). An inwardly rectifying chloride current sensitive to extracellular osmolality is present in pig pancreatic acinar cells.  Author URL.
CAREW MA, MASON WT (1993). STIMULATION OF CALCIUM (MANGANESE) INFLUX IN SINGLE, IDENTIFIED RAT LACTOTROPHS BY THYROTROPIN-RELEASING-HORMONE (TRH) AND THAPSIGARGIN.  Author URL.

Publications by year


2019

Easa N, Alany RG, Carew M, Vangala A (2019). A review of non-invasive insulin delivery systems for diabetes therapy in clinical trials over the past decade. DRUG DISCOVERY TODAY, 24(2), 440-451. Author URL.

2018

Carew M (2018). Using a word game to test physiology comprehension. ADVANCES IN PHYSIOLOGY EDUCATION, 42(3), 464-465. Author URL.

2017

Aldhaher A, Langat M, Ndunda B, Chirchir D, Midiwo JO, Njue A, Schwikkard S, Carew M, Mulholland D (2017). Diterpenoids from the roots of Croton dichogamus Pax. PHYTOCHEMISTRY, 144, 1-8. Author URL.

2015

Abdelkader H, Pierscionek B, Carew M, Wu Z, Alany RG (2015). Critical appraisal of alternative irritation models: three decades of testing ophthalmic pharmaceuticals. BRITISH MEDICAL BULLETIN, 113(1), 59-71. Author URL.

2014

Waheed A, Ludtmann MHR, Pakes N, Robery S, Kuspa A, Dinh C, Baines D, Williams RSB, Carew MA (2014). Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a TRPP2 ( polycystin-2)dependent manner. BRITISH JOURNAL OF PHARMACOLOGY, 171(10), 2659-2670. Author URL.

2013

Polycarpou E, Meira LB, Carrington S, Tyrrell E, Modjtahedi H, Carew MA (2013). Resveratrol 3-O-D-glucuronide and resveratrol 4 '-O-D-glucuronide inhibit colon cancer cell growth: Evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. MOLECULAR NUTRITION & FOOD RESEARCH, 57(10), 1708-1717. Author URL.

2012

Waheed A, Barker J, Barton SJ, Owen CP, Ahmed S, Carew MA (2012). A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cells. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 47(2), 464-473. Author URL.
Young JS, Matharu R, Carew MA, Fry CH (2012). Inhibition of stretching-evoked ATP release from bladder mucosa by anticholinergic agents. BJU INTERNATIONAL, 110(8B), E397-E401. Author URL.

2011

Tyrrell E, Brawn P, Carew M, Greenwood I (2011). An expedient conversion of alpha-amino acids into Weinreb amides using COMU (R) as a coupling agent. TETRAHEDRON LETTERS, 52(3), 369-372. Author URL.
Waheed A, Barker J, Barton SJ, Khan G-M, Najm-us-Saqib Q, Hussain M, Ahmed S, Owen C, Carew MA (2011). Novel acylated steroidal glycosides from Caralluma tuberculata induce caspase-dependent apoptosis in cancer cells. JOURNAL OF ETHNOPHARMACOLOGY, 137(3), 1189-1196. Author URL.

2010

Ganbold M, Barker J, Ma R, Jones L, Carew M (2010). Cytotoxicity and bioavailability studies on a decoction of Oldenlandia diffusa and its fractions separated by HPLC. J Ethnopharmacol, 131(2), 396-403. Abstract.  Author URL.

2005

Ribeiro CMP, Paradiso AM, Carew MA, Shears SB, Boucher RC (2005). Cystic fibrosis airway epithelial Ca-i(2+) signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 280(11), 10202-10209. Author URL.

2002

Ho MWY, Yang XN, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, et al (2002). Regulation of Ins(3,4,5,6)P-4 signaling by a reversible kinase/phosphatase. CURRENT BIOLOGY, 12(6), 477-482. Author URL.

2000

Carew MA, Thorn P (2000). Carbachol-stimulated chloride secretion in mouse colon: evidence of a role for autocrine prostaglandin E-2 release. EXPERIMENTAL PHYSIOLOGY, 85(1), 67-72. Author URL.
Carew MA, Yang XN, Schultz C, Shears SB (2000). myo-inositol 3,4,5,6-tetrakisphosphate inhibits an apical calcium-activated chloride conductance in polarized monolayers of a cystic fibrosis cell line. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(35), 26906-26913. Author URL.

1999

Yang X, Rudolf M, Carew MA, Yoshida M, Nerreter V, Riley AM, Chung SK, Bruzik KS, Potter BV, Schultz C, et al (1999). Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. J Biol Chem, 274(27), 18973-18980. Abstract.  Author URL.

1998

Carew MA, Ermolayeva E, Goddard CA, Thorn P (1998). PGE(2) release from unstimulated epithelial cells of the mouse descending colon is an autocrine regulator of cellular cAMP.  Author URL.

1997

Ferguson AV, Bicknell RJ, Carew MA, Mason WT (1997). Dissociated adult rat subfornical organ neurons maintain membrane properties and angiotensin responsiveness for up to 6 days. NEUROENDOCRINOLOGY, 66(6), 409-415. Author URL.

1996

Carew MA, Thorn P (1996). An inwardly rectifying chloride current sensitive to extracellular osmolality is present in pig pancreatic acinar cells.  Author URL.
Carew MA, Thorn P (1996). Identification of CIC-2-like chloride currents in pig pancreatic acinar cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 433(1-2), 84-90. Author URL.

1995

CAREW MA, MASON WT (1995). CONTROL OF CA2+ ENTRY INTO RAT LACTOTROPHS BY THYROTROPIN-RELEASING-HORMONE. JOURNAL OF PHYSIOLOGY-LONDON, 486(2), 349-360. Author URL.

1994

CAREW MA, WU ML, LAW GJ, TSENG YZ, MASON WT (1994). EXTRACELLULAR ATP ACTIVATES CALCIUM-ENTRY AND MOBILIZATION VIA P-2U-PURINOCEPTORS IN RAT LACTOTROPHS. CELL CALCIUM, 16(3), 227-235. Author URL.

1993

CAREW MA, MASON WT (1993). STIMULATION OF CALCIUM (MANGANESE) INFLUX IN SINGLE, IDENTIFIED RAT LACTOTROPHS BY THYROTROPIN-RELEASING-HORMONE (TRH) AND THAPSIGARGIN.  Author URL.

1992

CAREW MA, PALEOLOG EM, PEARSON JD (1992). THE ROLES OF PROTEIN-KINASE-C AND INTRACELLULAR CA2+ IN THE SECRETION OF VONWILLEBRAND-FACTOR FROM HUMAN VASCULAR ENDOTHELIAL-CELLS. BIOCHEMICAL JOURNAL, 286, 631-635. Author URL.

1991

PALEOLOG EM, CAREW MA, PEARSON JD (1991). EFFECTS OF TUMOR-NECROSIS-FACTOR AND INTERLEUKIN-1 ON VONWILLEBRAND-FACTOR SECRETION FROM HUMAN VASCULAR ENDOTHELIAL-CELLS. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 60(1-2), 279-285. Author URL.

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