University of Exeter Medical School

Professor Albert Basson

Professor Albert Basson

Professor of Neuroscience and Epigenetics

 M.A.Basson@exeter.ac.uk

 

Overview

Albert is Professor of Neuroscience and Epigenetics at the University of Exeter. He graduated with a BSc, BSc(Hons) and MSc in Biochemistry from the University of Pretoria, South Africa and obtained his PhD in Immunology from the University of Cambridge. After post-doctoral research in Molecular Immunology at the National Institute for Medical Research (Mill Hill) with Rose Zamoyska, he trained in developmental biology and genetics at the Mount Sinai School of Medicine in New York with Jonathan Licht, King’s College London with Ivor Mason and UCSF with Gail Martin as a recipient of a Wellcome Trust International Prize Travelling Fellowship.

He started his own research group at King’s College London in 2006. Prior to joining Exeter, he was Professor of Developmental Neurobiology in the Centre for Craniofacial and Regenerative Biology and the MRC Centre for Neurodevelopmental Disorders at King’s College London. His research has been supported by research grants from the Wellcome Trust, MRC, Simons Foundation Autism Research Initiative (SFARI), and the CHARGE Syndrome Foundation. Postgraduate students in his laboratory have been funded by the Wellcome Trust, MRC, BBSRC, SFARI, and the Anatomical Society and 12 students have completed their PhDs under his supervision. Research in his laboratory has provided insights into the mechanisms responsible for developmental birth defects, syndromes and neurodevelopmental disorders and has been published in top international journals.

His research in Exeter aims to understand how dysregulation of the epigenome affects the development and function of the brain. His group studies a number of rare genetic disorders caused by mutations in genes that encode chromatin regulators and seek to understand how epigenomic changes cause age-associated cognitive decline. Their long-term goals are to provide fundamental insights into the epigenetic mechanisms that underlie neurodevelopmental disorders and cognitive decline and to determine if targeting these mechanisms can provide novel therapeutic possibilities.

Qualifications

  • PGCAP (King’s College London)
  • PhD (Cantab) - Immunology
  • MSc (University of Pretoria) - Biochemistry
  • BSc (Hons) (University of Pretoria) - Biochemistry
  • BSc (University of Pretoria) - Biochemistry

Research group links

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Research

Research interests

Over 30% of known gene mutations that cause severe brain disorders in the human population affect genes that encode chromatin modifying or remodelling factors. The Basson lab primarily uses mouse models to understand how these mutations affect brain development and function to cause these disorders.

They are interested in specific structural brain abnormalities e.g. brain overgrowth and cerebellar hypoplasia and neuropsychiatric conditions like intellectual disability, autism and psychosis (schizophrenia).

Dysregulation of the epigenome is also associated with age-associated cognitive decline and dementia. His group is studying how reversible modification of chromatin regulates learning and memory throughout the life course to understand how chromatin abnormalities can cause cognitive decline associated with ageing.

Their long-term goals are to provide fundamental insights into the epigenetic mechanisms that underlie neurodevelopmental disorders and cognitive decline and to ask if targeting these mechanisms can provide novel therapeutic possibilities.

Research projects

A current focus is on factors that either methylate (me) chromatin at a specific amino acid residue (K4) on histone 3 (H3), or factors that “read” these H3K4me modifications and are recruited to H3K4-modified sites in the genome. These factors are implicated in a range of neurodevelopmental disorders, which include CHARGE syndrome, caused by CHD7 mutations, autism and intellectual disability caused by mutations in CHD8, KMT2A and KDM5B, and Kabuki syndrome and schizophrenia caused by mutation of KMT2D. We work closely with clinical geneticists to identify and characterise new genes associated with related disorders, as well as those specifically associated with cerebellar defects e.g. PRDM13.

Specific projects:

  • The role of the lysine demethylase KDM5B in ASD, intellectual disability and hippocampus-dependent learning and memory.
  • Dissecting cell type-specific epigenomic changes that underlie age-associated cognitive decline.
  • Pre-synaptic functions of the autism-associated factor CHD8.
  • Understanding the functions of CHD7 in development of the neocortex.
  • Rare chromatinopathies: New disorders, convergent epigenetic mechanisms and treatments.

Links


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Publications

Journal articles

Hu X, Xiao W, Lei Y, Green A, Lee X, Maradana MR, Gao Y, Xie X, Wang R, Chennell G, et al (2023). Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrier. Nature Communications, 14(1). Abstract.
Donovan APA, Rosko L, Ellegood J, Redhead Y, Green JBA, Lerch JP, Huang JKK, Basson MA (2023). Pervasive cortical and white matter anomalies in a mouse model for CHARGE syndrome. JOURNAL OF ANATOMY, 243(1), 51-65. Author URL.
Kerschbamer E, Arnoldi M, Tripathi T, Pellegrini M, Maturi S, Erdin S, Salviato E, Di Leva F, Sebestyen E, Dassi E, et al (2022). CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing. NUCLEIC ACIDS RESEARCH, 50(22), 12809-12828. Author URL.
Oates S, Absoud M, Goyal S, Bayley S, Baulcomb J, Sims A, Riddett A, Allis K, Brasch-Andersen C, Balasubramanian M, et al (2021). <i>ZMYND11</i> variants are a novel cause of centrotemporal and generalised epilepsies with neurodevelopmental disorder. CLINICAL GENETICS, 100(4), 412-429. Author URL.
Whittaker DE, Oleari R, Gregory LC, Le Quesne-Stabej P, Williams HJ, Torpiano JG, Formosa N, Cachia MJ, Field D, Lettieri A, et al (2021). A recessive <i>PRDM13</i> mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia. JOURNAL OF CLINICAL INVESTIGATION, 131(24). Author URL.
Zerbi V, Pagani M, Markicevic M, Matteoli M, Pozzi D, Fagiolini M, Bozzi Y, Galbusera A, Scattoni M, Provenzano G, et al (2021). Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes. MOLECULAR PSYCHIATRY, 26(12), 7610-7620. Author URL.
Ellingford RA, Panasiuk MJ, de Meritens ER, Shaunak R, Naybour L, Browne L, Basson MA, Andreae LC (2021). Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated <i>Chd8</i> haploinsufficient mice. MOLECULAR PSYCHIATRY, 26(7), 3614-3624. Author URL.
Hurley S, Mohan C, Suetterlin P, Ellingford R, Riegman KLH, Ellegood J, Caruso A, Michetti C, Brock O, Evans R, et al (2021). Distinct, dosage-sensitive requirements for the autism-associated factor CHD8 during cortical development. MOLECULAR AUTISM, 12(1). Author URL.
Gileadi TE, Swamy AK, Hore Z, Horswell S, Ellegood J, Mohan C, Mizuno K, Lundebye A-K, Giese KP, Stockinger B, et al (2021). Effects of Low-Dose Gestational TCDD Exposure on Behavior and on Hippocampal Neuron Morphology and Gene Expression in Mice. ENVIRONMENTAL HEALTH PERSPECTIVES, 129(5). Author URL.
Badodi S, Pomella N, Zhang X, Rosser G, Whittingham J, Niklison-Chirou MV, Lim YM, Brandner S, Morrison G, Pollard SM, et al (2021). Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation. NATURE COMMUNICATIONS, 12(1). Author URL.
Ahmed M, Moon R, Prajapati RS, James E, Basson MA, Streit A (2021). The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration. COMMUNICATIONS BIOLOGY, 4(1). Author URL.
Kelly E, Meng F, Fujita H, Morgado F, Kazemi Y, Rice LC, Ren C, Escamilla CO, Gibson JM, Sajadi S, et al (2020). Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits. Nat Neurosci, 23(9), 1102-1110. Abstract.  Author URL.
Saric N, Selby M, Ramaswamy V, Kool M, Stockinger B, Hogstrand C, Williamson D, Marino S, Taylor MD, Clifford SC, et al (2020). The AHR pathway represses TGFβ-SMAD3 signalling and has a potent tumour suppressive role in SHH medulloblastoma. SCIENTIFIC REPORTS, 10(1). Author URL.
Gutierrez-Barragan D, Basson MA, Panzeri S, Gozzi A (2019). Infraslow State Fluctuations Govern Spontaneous fMRI Network Dynamics. CURRENT BIOLOGY, 29(14), 2295-+. Author URL.
Vaquero M, Cuesta S, Anerillas C, Altes G, Ribera J, Basson MA, Licht JD, Egea J, Encinas M (2019). Sprouty1 Controls Genitourinary Development via its N-Terminal Tyrosine. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 30(8), 1398-1411. Author URL.
Suetterlin P, Hurley S, Mohan C, Riegman KLH, Pagani M, Caruso A, Ellegood J, Galbusera A, Crespo-Enriquez I, Michetti C, et al (2018). Altered Neocortical Gene Expression, Brain Overgrowth and Functional Over-Connectivity in <i>Chd8</i> Haploinsufficient Mice. CEREBRAL CORTEX, 28(6), 2192-2206. Author URL.
Kasah S, Oddy C, Basson MA (2018). Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes. JOURNAL OF ANATOMY, 233(6), 755-769. Author URL.
Janecka M, Mill J, Basson MA, Goriely A, Spiers H, Reichenberg A, Schalkwyk L, Fernandes C (2017). Advanced paternal age effects in neurodevelopmental disorders-review of potential underlying mechanisms. Transl Psychiatry, 7(1). Abstract.  Author URL.
Donovan APA, Yu T, Ellegood J, Riegman KLH, de Geus C, van Ravenswaaij-Arts C, Fernandes C, Lerch JP, Basson MA (2017). Cerebellar Vermis and Midbrain Hypoplasia Upon Conditional Deletion of <i>Chd7</i> from the Embryonic Mid-Hindbrain Region. FRONTIERS IN NEUROANATOMY, 11 Author URL.
Badodi S, Dubuc A, Zhang X, Rosser G, Jaeger MDC, Kameda-Smith MM, Morrissy AS, Guilhamon P, Suetterlin P, Li X-N, et al (2017). Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma. CELL REPORTS, 21(10), 2772-2784. Author URL.
Whittaker DE, Kasah S, Donovan APA, Ellegood J, Riegman KLH, Volk HA, McGonnell I, Lerch JP, Basson MA (2017). Distinct cerebellar foliation anomalies in a <i>CHD7</i> haploinsufficient mouse model of CHARGE syndrome. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS, 175(4), 465-477. Author URL.
Ahmed MU, Maurya AK, Cheng L, Jorge EC, Schubert FR, Maire P, Basson MA, Ingham PW, Dietrich S (2017). Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility. Developmental Biology, 430(1), 90-104. Abstract.
Whittaker DE, Riegman KLH, Kasah S, Mohan C, Yu T, Sala BP, Hebaishi H, Caruso A, Marques AC, Michetti C, et al (2017). The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression. JOURNAL OF CLINICAL INVESTIGATION, 127(3), 874-887. Author URL.
Donovan APA, Basson MA (2017). The neuroanatomy of autism - a developmental perspective. JOURNAL OF ANATOMY, 230(1), 4-15. Author URL.
Balasooriya GI, Johnson J-A, Basson MA, Rawlins EL (2016). An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium. DEVELOPMENTAL CELL, 37(1), 85-97. Author URL.
Jones KM, Saric N, Russell JP, Andoniadou CL, Scambler PJ, Basson MA (2015). CHD7 Maintains Neural Stem Cell Quiescence and Prevents Premature Stem Cell Depletion in the Adult Hippocampus. STEM CELLS, 33(1), 196-210. Author URL.
Basson MA, van Ravenswaaij-Arts C (2015). Functional Insights into Chromatin Remodelling from Studies on CHARGE Syndrome. TRENDS IN GENETICS, 31(10), 600-611. Author URL.
Magnani D, Hasenpusch-Theil K, Benadiba C, Yu T, Basson MA, Price DJ, Lebrand C, Theil T (2014). <i>Gli3</i> Controls Corpus Callosum Formation by Positioning Midline Guideposts During Telencephalic Patterning. CEREBRAL CORTEX, 24(1), 186-198. Author URL.
Dyer C, Blanc E, Hanisch A, Roehl H, Otto GW, Yu T, Basson MA, Knight R (2014). A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain. DEVELOPMENT, 141(1), 63-72. Author URL.
Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD (2014). Coordinated activity of <i>Spry1</i> and <i>Spry2</i> is required for normal development of the external genitalia. DEVELOPMENTAL BIOLOGY, 386(1), 1-11. Author URL.
Jackson A, Kasah S, Mansour SL, Morrow B, Basson MA (2014). Endoderm-specific deletion of Tbx1 reveals an FGF-independent role for Tbx1 in pharyngeal apparatus morphogenesis. Dev Dyn, 243(9), 1143-1151. Abstract.  Author URL.
Clegg JM, Conway CD, Howe KM, Price DJ, Mason JO, Turnbull JE, Basson MA, Pratt T (2014). Heparan Sulfotransferases Hs6st1 and Hs2st Keep Erk in Check for Mouse Corpus Callosum Development. JOURNAL OF NEUROSCIENCE, 34(6), 2389-2401. Author URL.
Basson MA, Wingate RJ (2013). Congenital hypoplasia of the cerebellum: developmental causes and behavioral consequences. FRONTIERS IN NEUROANATOMY, 7 Author URL.
Yu T, Meiners LC, Danielsen K, Wong MTY, Bowler T, Reinberg D, Scambler PJ, van Ravenswaaij-Arts CMA, Basson MA (2013). Deregulated FGF and homeotic gene expression underlies cerebellar vermis hypoplasia in CHARGE syndrome. ELIFE, 2 Author URL.
Pitera JE, Woolf AS, Basson MA, Scambler PJ (2012). <i>Sprouty1</i> Haploinsufficiency Prevents Renal Agenesis in a Model of Fraser Syndrome. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 23(11), 1790-1796. Author URL.
Simrick S, Szumska D, Gardiner JR, Jones K, Sagar K, Morrow B, Bhattacharya S, Basson MA (2012). Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling. DEVELOPMENTAL DYNAMICS, 241(8), 1310-1324. Author URL.
Gardiner JR, Jackson AL, Gordon J, Lickert H, Manley NR, Basson MA (2012). Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis. DEVELOPMENT, 139(18), 3456-3466. Author URL.
Economou AD, Ohazama A, Porntaveetus T, Sharpe PT, Kondo S, Basson MA, Gritli-Linde A, Cobourne MT, Green JBA (2012). Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate. NATURE GENETICS, 44(3), 348-U163. Author URL.
Collins S, Waickman A, Basson A, Kupfer A, Licht JD, Horton MR, Powell JD (2012). Regulation of CD4⁺ and CD8⁺ effector responses by Sprouty-1. PLoS One, 7(11). Abstract.  Author URL.
Basson MA (2012). Signaling in Cell Differentiation and Morphogenesis. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 4(6). Author URL.
Macia A, Gallel P, Vaquero M, Gou-Fabregas M, Santacana M, Maliszewska A, Robledo M, Gardiner JR, Basson MA, Matias-Guiu X, et al (2012). Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma. ONCOGENE, 31(35), 3961-3972. Author URL.
Chakkalakal JV, Jones KM, Basson MA, Brack AS (2012). The aged niche disrupts muscle stem cell quiescence. NATURE, 490(7420), 355-+. Author URL.
Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan KM, Allen S, Basson MA, Francis-West P, Irvine KD (2011). Characterization of a <i>Dchs1</i> mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. DEVELOPMENT, 138(5), 947-957. Author URL.
Porntaveetus T, Otsuka-Tanaka Y, Basson MA, Moon AM, Sharpe PT, Ohazama A (2011). Expression of fibroblast growth factors (Fgfs) in murine tooth development. JOURNAL OF ANATOMY, 218(5), 534-543. Author URL.
Simrick S, Lickert H, Basson MA (2011). Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo. DEVELOPMENTAL BIOLOGY, 358(1), 147-155. Author URL.
Yu T, Yaguchi Y, Echevarria D, Martinez S, Basson MA (2011). Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. DEVELOPMENT, 138(14), 2957-2968. Author URL.
Akbulut S, Reddi AL, Aggarwal P, Ambardekar C, Canciani B, Kim MKH, Hix L, Vilimas T, Mason J, Basson MA, et al (2010). Sprouty Proteins Inhibit Receptor-mediated Activation of Phosphatidylinositol-specific Phospholipase C. MOLECULAR BIOLOGY OF THE CELL, 21(19), 3487-3496. Author URL.
Shea KL, Xiang W, LaPorta VS, Licht JD, Keller C, Basson MA, Brack AS (2010). Sprouty1 Regulates Reversible Quiescence of a Self-Renewing Adult Muscle Stem Cell Pool during Regeneration. CELL STEM CELL, 6(2), 117-129. Author URL.
Yaguchi Y, Yu T, Ahmed MU, Berry M, Mason I, Basson MA (2009). Fibroblast Growth Factor (FGF) Gene Expression in the Developing Cerebellum Suggests Multiple Roles for FGF Signaling During Cerebellar Morphogenesis and Development. DEVELOPMENTAL DYNAMICS, 238(8), 2058-2072. Author URL.
Randall V, McCue K, Roberts C, Kyriakopoulou V, Beddow S, Barrett AN, Vitelli F, Prescott K, Shaw-Smith C, Devriendt K, et al (2009). Great vessel development requires biallelic expression of <i>Chd7</i> and <i>Tbx1</i> in pharyngeal ectoderm in mice. JOURNAL OF CLINICAL INVESTIGATION, 119(11), 3301-3310. Author URL.
Rozen EJ, Schmidt H, Dolcet X, Basson MA, Jain S, Encinas M (2009). Loss of Sprouty1 Rescues Renal Agenesis Caused by Ret Mutation. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 20(2), 255-259. Author URL.
Calmont A, Ivins S, Van Bueren KL, Papangeli I, Kyriakopoulou V, Andrews WD, Martin JF, Moon AM, Illingworth EA, Basson MA, et al (2009). Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating <i>Gbx2</i> expression in the pharyngeal ectoderm. DEVELOPMENT, 136(18), 3173-3183. Author URL.
Klein OD, Lyons DB, Balooch G, Marshall GW, Basson MA, Peterka M, Boran T, Peterkova R, Martin GR (2008). An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. DEVELOPMENT, 135(2), 377-385. Author URL.
Parravicini V, Field A-C, Tomlinson PD, Basson MA, Zamoyska R (2008). Itch<SUP>-/-</SUP>αβ and γδ T cells independently contribute to autoimmunity in Itchy mice. BLOOD, 111(8), 4273-4282. Author URL.
Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, et al (2008). MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. NATURE, 456(7224), 980-U83. Author URL.
Basson MA, Echevarria D, Ahn CP, Sudarov A, Joyner AL, Mason IJ, Martinez S, Martin GR (2008). Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development. DEVELOPMENT, 135(5), 889-898. Author URL.
Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, Costantini FD, Wilson PD, Mason IJ, Licht JD (2006). Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. DEVELOPMENTAL BIOLOGY, 299(2), 466-477. Author URL.
Mason JM, Morrison DJ, Basson MA, Licht JD (2006). Sprouty proteins: Multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends in Cell Biology, 16(1), 45-54. Abstract.
Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, et al (2005). Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Developmental Cell, 8(2), 229-239. Abstract.
Lin W, Jing N, Basson MA, Dierich A, Licht J, Ang SL (2005). Synergistic activity of Sef and Sprouty proteins in regulating the expression of Gbx2 in the mid-hindbrain region. Genesis (United States), 41(3), 110-115. Abstract.
Zamoyska R, Basson A, Filby A, Legname G, Lovatt M, Seddon B (2003). The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation. Immunol Rev, 191, 107-118. Abstract.  Author URL.
Basson MA, Zamoyska R (2001). Insights into T-cell development from studies using transgenic and knockout mice. Applied Biochemistry and Biotechnology - Part B Molecular Biotechnology, 18(1), 11-23. Abstract.
Basson MA, Zamoyska R (2000). The CD4/CD8 lineage decision: Integration of signalling pathways. Immunology Today, 21(10), 509-514. Abstract.
Basson MA, Bommhardt U, Cole MS, Tso JY, Zamoyska R (1998). Cd3 ligation on immature thymocytes generates antagonist-like signals appropriate for CD8 lineage commitment, independently of T cell receptor specificity. Journal of Experimental Medicine, 187(8), 1249-1260. Abstract.

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External Engagement and Impact

Awards

2009:                Royal Society International Travel Grant

2001-2003:        Wellcome Trust International Prize Travelling Fellowship

1992-1995:        Cambridge Overseas Trust Local Examinations Syndicate Scholarship

                        Overseas Research Students Award, United Kingdom

                        Emmanuel College External Research Scholarship

                        Cambridge Philosophical Society Studentship

1986-1992:        Standard Bank Scholarship

                        University of Pretoria Merit Bursaries

                        Academic Colours of the University of Pretoria


Committee/panel activities

  • Director, MRC Epigenomics Rare Diseases Node

Editorial responsibilities

  • Editorial Board: Cells, since 2020
  • Guest Associate editor: Transcription and Translation Defects in Neurocognitive and Neurobehavioral Disorders: Towards Accurate Diagnostics and Novel Therapeutics, Frontiers in Molecular Biosciences (2020)
  • Guest Associate editor: Topic on chromatin remodeling in neurodevelopmental disorders, Frontiers in Molecular Neuroscience (2016-17)

Invited lectures

  • 2022-09-07-09:   Neurodevelopmental Disorders Conference including a Helmsmoortel van der Aa syndrome patient community day, University of Antwerp, Belgium, Invited speaker.
  • 2022-06-14:       Nuffield Department of Clinical Neurosciences, University of Oxford, Invited seminar.
  • 2022-05-20:      Korean Society for Brain and Neural Sciences (KSBNS) Annual Meeting, Invited speaker.
  • 2022-05-18:      Korea Advanced Institute of Science and Technology (KAIST), Invited speaker.
  • 2022-05-17:       Yonsei University, Seoul, Korea, Invited speaker.
  • 2020-07-12:       FENS 2020, Glasgow, UK (Virtual), Invited speaker.
  • 2019-09-02:       23rd ESN Biennial meeting, Milan, Italy, Invited speaker.
  • 2019-08-06:       Gordon Research Conference on Genome Architecture in Cell Fate and Disease, Hong Kong, Talk selected from abstracts.
  • 2019-03-28:       Division of Evolution and Genomic Sciences and Centre for Genomic Medicine, University of Manchester, Invited seminar.
  • 2019-01-14:       Chromatin Biology Symposium, University of Michigan, Ann Arbor, USA, Invited speaker.
  • 2018-11-06:       Society for Neuroscience annual meeting, San Diego, CA, USA. Selected talk and Chair of Nanosymposium: Autism: From Genetic Models to Insight.
  • 2018-10-19:       CHARGE family support group professional day and conference, Birmingham, UK, Invited speaker.
  • 2018-09-03:       Epigenetics in the nervous system: development and disease conference, Stockholm, Sweden, unable to attend due to family tragedy.
  • 2018-07-24:       Anatomical Society Summer meeting on Human Cerebral Cortex Development, University of Oxford, Short talk.
  • 2017-07-31:       UFHealth Cancer Centre seminar, University of Florida, Gainesville, USA, Invited seminar.
  • 2017-07-27:       13th International CHARGE syndrome conference, Orlando Florida, USA, Plenary speaker.

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Teaching

NEU3001

NEU3008

NEU1909

NEUM002

NEUM006

R-SSU

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