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Dr Thomas Ridler

Dr Thomas Ridler

Associate Lecturer in Neuroscience

 6752

 01392 726752

 Hatherly D12

 

Hatherly Building, University of Exeter, Prince of Wales Road, Exeter, EX4 4PS, UK

Overview

Tom received an undergraduate masters (MSci) in ‘Neuroscience with study in industry’ from the University of Bristol, during which time he spent a year working at Eli Lilly on new drug targets for cognitive impairment in Alzheimer’s and Schizophrenia. He moved to Exeter as a PhD student under the supervision of Dr Jon Brown and Prof Andrew Randall after which he took up a role as a postdoctoral researcher in the Exeter applied Neurophysiology group investigating entorhinal cortex dysfunction in rodent models of dementia. In 2020 he was appointed associate lecturer in Neuroscience.

Qualifications

  • MSci Neuroscience with study in industry (University of Bristol)
  • PhD Medical Studies (University of Exeter)

Research

Research interests

Tom is interested in how neurological diseases such as Alzheimer’s disease and Epilepsy produce changes to neuronal networks that ultimately affect cognitive processes. He uses in vivo electrophysiological recordings to measure the activity of neurons from awake-behaving mice, either at the level of single-cells or through large-scale neuronal networks. His current work focuses on the medial entorhinal cortex, one of the first areas to be affected by Alzheimer’s disease pathology, which is essential for processing spatial information.

 

Publications

Walsh, C., Ridler, T., Garrido, M.G., Witton, J., Randall, A.D., Brown, J.T., (2021). Beta bursting in the retrosplenial cortex is a neurophysiological correlate of environmental novelty which is disrupted in a mouse model of Alzheimer’s disease. bioRxiv 2021.04.26.441462. 

Ridler, T., Witton, J., Phillips, K. G., Randall, A. D. and Brown, J. T. (2020) Impaired speed encoding and reduced grid cell periodicity in a mouse model of tauopathy. Elife, Nov 26;9:e59045. doi: 10.7554/eLife.59045. PMID: 33242304.

Creaser, J, Lin, C , Ridler, T, Brown, JT,  D’Souza, W, Seneviratne, S, Cook, M,  Terry JR, Tsaneva-Atanasova, K (2020) Domino-like transient dynamics at seizure onset in epilepsy. PLOS Comput. Biol. 16(9): e1008206.

Ridler, T. Matthews P, Phillips KG, Randall AD, Brown JT. (2018) Initiation and slow propagation of epileptiform activity from ventral to dorsal medial entorhinal cortex is constrained by an inhibitory gradient. J Physiol, 2018; 596(11) 2251-2266. 

Booth, CA.*, Ridler T.* Murray, T. K., Ward, M. A., de Groot, E., Goodfellow, M., Phillips, K. G., Randall, A. D., & Brown, J. T. (2016) Electrical and Network Neuronal Properties Are Preferentially Disrupted in Dorsal, But Not Ventral, Medial Entorhinal Cortex in a Mouse Model of Tauopathy. J Neurosci, 2016; 36  *equal contributions

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