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 Sian Grace

Sian Grace

PhD Student

 RILD Building Level 3

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Sian completed her MSc degree at the University of the West of England (Bristol) in 2015 where she specialized in blood sciences. Following her interest in autoimmune disorders, she took up a technician role in the European Islet Autoantibody Reference Laboratory based in the Diabetes and Metabolism group at the University of Bristol. Sian subsequently moved into a research technician role specializing in developing novel non-radioactive high-throughput methods for the detection of these islet autoantibodies.

Sian joined the University of Exeter in September 2019 after being awarded an E3 PhD Studentship. Sian’s PhD research; working with Dr Angus Jones; is focused on improving adult diagnosis of Type 1 Diabetes using islet autoantibodies.

Qualifications

  • MSc Biomedical Sciences (Blood Sciences)
  • BSc Applied Biomedical Sciences (Clinical)

Grants/Funding:

  • E3 PhD Studentship

Research

Research interests

Previously Sian has been involved in the development of novel luciferase based assay systems for the detection of islet autoantibodies. Her research involved creating small volume, multiplexed and alternative format assays with enhanced sensitivity and specificity.

Her PhD with Dr Angus Jones will involve improving the clinical utility of islet autoantibodies with a focus on improving classification and diagnosis of diabetes in adults.

Research projects

Current Projects:

  • Improving Adult Diagnosis of Type 1 Diabetes using Islet Autoantibodies

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Grace SL, Bowden J, Walkey HC, Kaur A, Misra S, Shields BM, McKinley TJ, Oliver NS, McDonald TJ, Johnston DG, et al (2022). Islet Autoantibody Level Distribution in Type 1 Diabetes and Their Association with Genetic and Clinical Characteristics. J Clin Endocrinol Metab, 107(12), e4341-e4349. Abstract.  Author URL.
Grace SL, Cooper A, Jones AG, McDonald TJ (2021). Zinc transporter 8 autoantibody testing requires age-related cut-offs. BMJ Open Diabetes Research & Care, 9(1), e002296-e002296. Abstract.

Conferences

Grace SL, Cooper A, Jones AG, McDonald TJ (2020). Zinc transporter 8 autoantibody testing requires age-specific cut-offs.  Author URL.

Publications by year


In Press

Wyatt RC, Grace SL, Brigatti C, Marzinotto I, Gillard BT, Shoemark D, Chandler K, Achenbach P, Piemonti L, Long AE, et al (In Press). Improved specificity of glutamate decarboxylase 65 autoantibody measurement using luciferase-based immunoprecipitation system (LIPS) assays.  Abstract.

2023

Grace SL (2023). Improving diagnosis of adult-onset diabetes using islet autoantibodies.  Abstract.

2022

Grace SL, Bowden J, Walkey HC, Kaur A, Misra S, Shields BM, McKinley TJ, Oliver NS, McDonald TJ, Johnston DG, et al (2022). Islet Autoantibody Level Distribution in Type 1 Diabetes and Their Association with Genetic and Clinical Characteristics. J Clin Endocrinol Metab, 107(12), e4341-e4349. Abstract.  Author URL.

2021

Grace SL, Bowden J, Walkey HC, Kaur A, Misra S, Shields BM, McKinley TJ, Oliver NS, McDonald T, Johnston DG, et al (2021). Islet autoantibody level distributions in type 1 diabetes and their association with genetic and clinical characteristics.
Grace SL, Cooper A, Jones AG, McDonald TJ (2021). Zinc transporter 8 autoantibody testing requires age-related cut-offs. BMJ Open Diabetes Research & Care, 9(1), e002296-e002296. Abstract.

2020

Grace SL, Cooper A, Jones AG, McDonald TJ (2020). Zinc transporter 8 autoantibody testing requires age-specific cut-offs.  Author URL.

Sian_Grace Details from cache as at 2023-09-30 17:58:28

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Teaching

Supervision / Group

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