COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Shalinee Dhayal

Postdoctoral Research Associate

 01392 408224

 RILD Building S4.01 (Level 4)

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Shalinee Dhayal is a Postdoctoral Research Associate at University of Exeter Medical School with research interests in the field of diabetes. After obtaining her PhD from Peninsula College of Medicine and Dentistry, Universities of Exeter and Plymouth in Oct 2008, she worked as a Postdoctoral Research Fellow in the same institution. Over this period she developed interest in understanding the role of long chain fatty acids in pancreatic beta cell function and viability, particularly molecular mechanisms involved in the cytoprotective effects of unsaturated fatty acids. Her research interests also expanded in understanding the aetiology of Type 1 diabetes focusing on role of enteroviral infections in development of Type 1 diabetes. She returned after 4 year career break and resumed her research in the field of diabetes as a Postdoctoral Research Associate. Currently, along with her research contract, she is also employed as an Associate Lecturer in Medical Sciences.
 

Qualifications

  • Fellow of ASPIRE and Higher Education Academy (HEA)
  • PhD (Endocrine Pharmacology)
  • MSc (Applied Microbiology)
  • BSc (Chemistry, Zoology and Botany)

Research

Research interests

Research Projects

  • Investigating role of transcription factor STAT1 in the development of Type 1 Diabetes.
  • Investigating role of enteroviruses in the progression of type 1 diabetes using two unique cohorts of patient pancreas samples. Primarily focusing on the detection of enteroviruses within the islets and understanding the molecular signalling associated with viral infection.
  • Investigating the molecular mechanisms involved in the cytoprotective effects of long chain unsaturated fatty acids in pancreatic beta cells.

Research projects

Currently, Shalinee is investigating expression of phosphorylated form of microtubule associated protein Tau in Type 1 and Type 2 diabetes cases largely achieved using state-of-the-art imaging equipment and emerging image analysis platforms. This project exploits unique access to biobanks of human pancreatic tissue (including the Exeter Archival Diabetes Biobank (EADB) and The JDRF network of Pancreatic Organ Donors (nPOD) collection).

Grants/Funding:

  • £500 grant received from Exeter University for Researcher led initiatives (2019).
  • £5000 grant received from Sir Halley Steward Trust for performing a PCR array to investigate the cytoprotective effects of long chain unsaturated fatty acids in pancreatic beta cells (2019).
  • £500 grant received for attending a research conference from Tavistock Inner Wheel Club (2006).

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Ifie E, Russell M, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik D, Morgan N, et al (In Press). Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia Full text.
Dhayal S, Zummo FP, Anderson MW, Thomas P, Welters HJ, Arden C, Morgan NG (2019). Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells. J Mol Endocrinol, 63(4), 285-296. Abstract.  Author URL.  Full text.
Ferru-Clément R, Spanova M, Dhayal S, Morgan NG, Hélye R, Becq F, Hirose H, Antonny B, Vamparys L, Fuchs PFJ, et al (2016). Targeting surface voids to counter membrane disorders in lipointoxication-related diseases. J Cell Sci, 129(12), 2368-2381. Abstract.  Author URL.
Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG (2014). GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia, 57(6), 1182-1191. Abstract.  Author URL.  Full text.
Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.
Stone VM, Dhayal S, Smith DM, Lenaghan C, Brocklehurst KJ, Morgan NG (2012). The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. Br J Pharmacol, 165(8), 2758-2770. Abstract.  Author URL.
Keane DC, Takahashi HK, Dhayal S, Morgan NG, Curi R, Newsholme P (2011). Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clin Sci (Lond), 120(5), 195-206. Abstract.  Author URL.
Johnstone KA, Diakogiannaki E, Dhayal S, Morgan NG, Harries LW (2011). Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid. JOP, 12(1), 6-10. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells. Br J Pharmacol, 162(6), 1340-1350. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Structure-activity relationships influencing lipid-induced changes in eIF2α phosphorylation and cell viability in BRIN-BD11 cells. FEBS Lett, 585(14), 2243-2248. Abstract.  Author URL.
Dhayal S, Morgan NG (2010). The significance of GPR119 agonists as a future treatment for type 2 diabetes. Drug News Perspect, 23(7), 418-424. Abstract.  Author URL.
Morgan NG, Dhayal S (2010). Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell. Prostaglandins Leukot Essent Fatty Acids, 82(4-6), 231-236. Abstract.  Author URL.
Morgan NG, Dhayal S (2009). G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem Pharmacol, 78(12), 1419-1427. Abstract.  Author URL.
Dhayal S, Welters HJ, Morgan NG (2008). Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11. Br J Pharmacol, 153(8), 1718-1727. Abstract.  Author URL.
Morgan NG, Dhayal S, Diakogiannaki E, Welters HJ (2008). The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells. Biochem Soc Trans, 36(Pt 5), 905-908. Abstract.  Author URL.
Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG (2007). Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol, 194(2), 283-291. Abstract.  Author URL.

Publications by year


In Press

Ifie E, Russell M, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik D, Morgan N, et al (In Press). Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia Full text.

2019

Dhayal S, Zummo FP, Anderson MW, Thomas P, Welters HJ, Arden C, Morgan NG (2019). Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells. J Mol Endocrinol, 63(4), 285-296. Abstract.  Author URL.  Full text.

2016

Ferru-Clément R, Spanova M, Dhayal S, Morgan NG, Hélye R, Becq F, Hirose H, Antonny B, Vamparys L, Fuchs PFJ, et al (2016). Targeting surface voids to counter membrane disorders in lipointoxication-related diseases. J Cell Sci, 129(12), 2368-2381. Abstract.  Author URL.

2014

Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG (2014). GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia, 57(6), 1182-1191. Abstract.  Author URL.  Full text.

2013

Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.  Full text.

2012

Stone VM, Dhayal S, Smith DM, Lenaghan C, Brocklehurst KJ, Morgan NG (2012). The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. Br J Pharmacol, 165(8), 2758-2770. Abstract.  Author URL.

2011

Keane DC, Takahashi HK, Dhayal S, Morgan NG, Curi R, Newsholme P (2011). Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clin Sci (Lond), 120(5), 195-206. Abstract.  Author URL.
Johnstone KA, Diakogiannaki E, Dhayal S, Morgan NG, Harries LW (2011). Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid. JOP, 12(1), 6-10. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells. Br J Pharmacol, 162(6), 1340-1350. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Structure-activity relationships influencing lipid-induced changes in eIF2α phosphorylation and cell viability in BRIN-BD11 cells. FEBS Lett, 585(14), 2243-2248. Abstract.  Author URL.

2010

Dhayal S, Morgan NG (2010). The significance of GPR119 agonists as a future treatment for type 2 diabetes. Drug News Perspect, 23(7), 418-424. Abstract.  Author URL.
Morgan NG, Dhayal S (2010). Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell. Prostaglandins Leukot Essent Fatty Acids, 82(4-6), 231-236. Abstract.  Author URL.

2009

Morgan NG, Dhayal S (2009). G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem Pharmacol, 78(12), 1419-1427. Abstract.  Author URL.

2008

Dhayal S, Welters HJ, Morgan NG (2008). Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11. Br J Pharmacol, 153(8), 1718-1727. Abstract.  Author URL.
Morgan NG, Dhayal S, Diakogiannaki E, Welters HJ (2008). The cytoprotective actions of long-chain mono-unsaturated fatty acids in pancreatic beta-cells. Biochem Soc Trans, 36(Pt 5), 905-908. Abstract.  Author URL.

2007

Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG (2007). Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol, 194(2), 283-291. Abstract.  Author URL.

Shalinee_Dhayal Details from cache as at 2021-09-16 08:47:27

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External Engagement and Impact

Awards

Awards:

  • Patent:-Compounds or compositions for the treatment of dyslipidemias. Centre National de la Recherche Scientifique / Université de Poitiers / University of Exeter. PCT/FR2014/052546 (2016).
  • Abstract nominated for New Investigator award at the 9th conference of the international society for the study of fatty acids and lipids (ISSFAL), 2010.
  • Abstract nominated for Nick Hales Young Investigator award at Diabetes UK Annual Professional Conference, 2007. 
  • Award won for best abstract and oral presentation at Peninsula Postgraduate Health Institute Annual Research Event (March 9th-10th 2006).
  • Selected among the 11 candidates from UK for attending Lindau Nobel Laureate Meeting (2006).

Teaching

Supervise PhD students and undergraduate students on research projects.

Medical Science

Yr1 - Small group (SSGL) facilitation for Integrated human physiology

Yr1 - Literature Review Research Group (SCG) facilitation 

Yr1 - Small group facilitation for Medical Genetics

BMBS

Yr1 - Small group (PBL) facilitator

Yr1 - Biomedical Science SSU provider

Yr2 - LSRC session provider

Yr2 - Lecture provider

Supervision / Group

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