Journal articles
Whear R, Bethel A, Abbott R, Rogers M, Orr N, Manzi S, Ukoumunne OC, Stein K, Coon JT (2022). Systematic reviews of convalescent plasma in COVID-19 continue to be poorly conducted and reported: a systematic review. Journal of Clinical Epidemiology, 151, 53-64.
Manzi S, Chalk D, Day J, Pearson M, Lang I, Stein K, Pitt M (2017). A novel modelling and simulation capacity development initiative for the National Health Service. BMJ Simulation and Technology Enhanced Learning, 4(2), 97-98.
Chalk D, Manzi S, Britten N, Kluettgens B, Magura R, Valderas J (2017). Can agent-based simulation be used as a tool to support polypharmacy prescribing practice?.
BMJ Simulation and Technology Enhanced Learning,
3(3), 94-98.
Abstract:
Can agent-based simulation be used as a tool to support polypharmacy prescribing practice?
ObjectiveWe sought to develop a simulation modelling method to help better understand the complex interplay of factors that lead to people with type 2 diabetes and asthma not taking all of their medication as prescribed when faced with multiple medications (polypharmacy).Research design and methodsIn collaboration with polypharmacy patients, general practitioners, pharmacists and polypharmacy researchers, we developed a map of factors that directly and indirectly affect somebody’s decision to take their medication as prescribed when faced with multiple type 2 diabetes and asthma medications. We then translated these behavioural influences into logical rules using data from the literature and developed a proof-of-concept agent-based simulation model that captures the medicine-taking behaviours of those with type 2 diabetes and asthma taking multiple medications and which predicts both the clinical effectiveness and rates of adherence for different combinations of medications.ConclusionsThe model we have developed could be used as a prescription support tool or a way of estimating medicine-taking behaviour in cost-effectiveness analyses.
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Manzi S, Nichols A, Richardson J (2016). A comparison of waste compositions at health and social care facilities.
British Journal of Healthcare Management,
22(9), 469-474.
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A comparison of waste compositions at health and social care facilities
Sustainability is an issue for both healthcare and social care organisations. Understanding the similarities and differences between healthcare and social care waste compositions, especially the amounts of potentially recyclable waste, can help target waste reduction strategies more effectively. A waste audit was undertaken at four health and social care sites in the South West of England. A comparison was made between the waste compositions of healthcare clinical and domestic waste streams and those of social care sites. Over a three-month period, 115 bags of waste (69 clinical and 46 domestic waste bags) were weighed and the contents catalogued. A greater number of items and unique item types were found on average at the healthcare site in comparison to the social care sites. The domestic waste streams at all four sites contained high proportions of potentially recyclable wastes. The clinical waste stream of the healthcare site also contained the highest proportion of potentially recyclable waste (66%). The differences in the amounts of potentially recyclable waste between the four study sites demonstrate the importance of understanding the composition of the different waste streams to inform the design of effective and impactful interventions.
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Manzi S, Nichols A, Richardson J (2016). A study of health and social care waste management behaviour.
British Journal of Healthcare Management,
22(7), 360-366.
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A study of health and social care waste management behaviour
Understanding waste management behaviour requires a range of data collection approaches. Observational studies collecting qualitative data are as useful as quantitative studies for understanding behaviour. Previous studies have examined quantities of waste being disposed of, who disposed of the waste, and the material composition of the waste, however, attention to the motivations and reasoning behind the disposal of the waste has been limited. The study was conducted at one healthcare site and three social care sites in the South West of England from 1 May to 31 July 2012. Data were collected by overt observation using photographs, diagrammatic sketches, field notes and digitally recorded informal discussions with employees responsible for disposing of waste. Three primary themes were evident in the data; communication; influence of the environment on the employee; how employees think about waste management. Ensuring that the environment facilitates appropriate waste management behaviour can help improve waste segregation and recycling rates. Clear and visible communication of waste management information will help remind employees how best to dispose of waste. Understanding how employees think about waste management can inform the development of interventions to improve overall waste management practice.
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Richardson J, Grose J, Manzi S, Mills I, Moles DR, Mukonoweshuro R, Nasser M, Nichols A (2016). What's in a bin: a case study of dental clinical waste composition and potential greenhouse gas emission savings.
Br Dent J,
220(2), 61-66.
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What's in a bin: a case study of dental clinical waste composition and potential greenhouse gas emission savings.
BACKGROUND: Dental practices have a unique position as dental staff use a high number of dental materials and instruments on a daily basis. It is unclear how dentists' and dental care professionals' choices and behaviours around selecting and using materials impact on the amount of unnecessary waste production. Although there are a number of articles exploring the quality and quantity of waste in dental practices, there are no studies on organisational strategies to decrease unnecessary waste. There is no clear economic analysis of the impact on associated cost to dental practices which consequently can affect the access of dental care for disadvantaged groups. METHODS: This study used an audit approach to explore the potential for sustainability in dental practice by measuring the nature and quantity of dental clinical waste, and assessing the feasibility of measuring the financial costs and potential carbon savings in the management of dental clinical waste. CONCLUSIONS: the data from our study would appear to support the view that it is possible to reduce carbon emissions and increase profitability. Successful implementation of an environmentally sustainable approach to waste management will be dependent on the practicalities involved and the financial incentives for adopting such practices.
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Richardson J, Grose J, Manzi S, Mills I, Moles DR, Mukonoweshuro R, Nasser M, Nichols A (2016). What's in a bin?. BDJ Team, 3(5).
Manzi S, Nichols A, Richardson J (2014). A non-participant observational study of health and social care waste disposal behaviour in the South West of England.
J Health Serv Res Policy,
19(4), 231-235.
Abstract:
A non-participant observational study of health and social care waste disposal behaviour in the South West of England.
INTRODUCTION: the National Health Service in England has a large carbon footprint. Waste production and disposal contributes to this carbon footprint and costs the National Health Service England over £82 million per annum. This study builds on existing work regarding health care waste management in the United Kingdom where the potential for recycling has begun to be studied. The study focuses on a private hospital and social care organizations, and provides a more detailed study of the behaviour of individuals across a variety of waste management systems. METHODS: the study was an overt observational study at four health and social care sites in the South West of England. Systematic observations were made of the waste disposed of by employees in which the observer recorded: a description of the waste item; the bin into which the waste was placed; the type of employee who disposed of the waste; the material the waste comprised and the appropriateness of the disposal behaviour. RESULTS: the domestic waste bin was found to be most commonly used by employees to dispose of waste (51%), and the materials observed being disposed of most often were paper (26%), organic wastes (19%) and plastic (19%). There were significant differences between the four sites indicating that the activities performed at each site may have been influencing the waste being disposed of. CONCLUSION: it was concluded that the transfer of waste from the domestic waste stream to the recycling waste stream should be a central focus for the design of new health and social care waste management systems. Employees will require guidance and training in identifying and classifying waste materials for recycling.
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Harris CM, Waddington J, Biscione V, Manzi S (2014). Manual choice reaction times in the rate-domain.
Front Hum Neurosci,
8Abstract:
Manual choice reaction times in the rate-domain.
Over the last 150 years, human manual reaction times (RTs) have been recorded countless times. Yet, our understanding of them remains remarkably poor. RTs are highly variable with positively skewed frequency distributions, often modeled as an inverse Gaussian distribution reflecting a stochastic rise to threshold (diffusion process). However, latency distributions of saccades are very close to the reciprocal Normal, suggesting that "rate" (reciprocal RT) may be the more fundamental variable. We explored whether this phenomenon extends to choice manual RTs. We recorded two-alternative choice RTs from 24 subjects, each with 4 blocks of 200 trials with two task difficulties (easy vs. difficult discrimination) and two instruction sets (urgent vs. accurate). We found that rate distributions were, indeed, very close to Normal, shifting to lower rates with increasing difficulty and accuracy, and for some blocks they appeared to become left-truncated, but still close to Normal. Using autoregressive techniques, we found temporal sequential dependencies for lags of at least 3. We identified a transient and steady-state component in each block. Because rates were Normal, we were able to estimate autoregressive weights using the Box-Jenkins technique, and convert to a moving average model using z-transforms to show explicit dependence on stimulus input. We also found a spatial sequential dependence for the previous 3 lags depending on whether the laterality of previous trials was repeated or alternated. This was partially dissociated from temporal dependency as it only occurred in the easy tasks. We conclude that 2-alternative choice manual RT distributions are close to reciprocal Normal and not the inverse Gaussian. This is not consistent with stochastic rise to threshold models, and we propose a simple optimality model in which reward is maximized to yield to an optimal rate, and hence an optimal time to respond. We discuss how it might be implemented.
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Nichols A, Manzi S (2014). Physical space and its impact on waste management in the neonatal care setting.
Journal of Infection Prevention,
15(4), 134-138.
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Physical space and its impact on waste management in the neonatal care setting
This paper reports an investigation intended to obtain some understanding of how the working environment might influence the practice and knowledge of those involved in the management of healthcare waste. The National Health Service (NHS) has a continuing waste problem, and the way it manages waste harms the environment and consumes resources. It has been estimated that the carbon footprint of the NHS in England is approximately 20 million tons of CO2e. It has been suggested that better waste segregation could lead to more effective recycling, saving up to 42,000 tonnes of CO2. This qualitative study employed non-participant observation and semi-structured interviews. The interviews were carried out with the key informants within the participating neonatal intensive care unit. Findings from this study indicate that space and the physical arrangement of the environment are significant and influential factors in clinical practice. Where the clinical environment is not supportive, poor infection control and waste management practice is likely to occur. However, proximity of staff caused by a lack of physical space might facilitate situated learning and a collective development of knowledge in practice. The implementation of sustainable waste management practices would be more likely to succeed in an environment that facilitates correct waste segregation.
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Conferences
Whear R, Bethel A, Abbott R, Rogers M, Orr N, Manzi S, Ukoumunne O, Stein K, Coon JT (2022). P58 We need to talk about solutions looking through the lens of evidence syntheses of convalescent plasma therapy: a systematic review. SSM Annual Scientific Meeting.
Pearn K, Manzi S, Winterton L (2018). Visualisation of the service use for individual clients with a Personality Disorder at Devon Partnership Trust to support clinical decision making. ORAHS 2018. 30th Jul - 3rd Aug 2018.
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Visualisation of the service use for individual clients with a Personality Disorder at Devon Partnership Trust to support clinical decision making
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Manzi S, Chalk D, Pearson M, Day J, Stein K, Lang I, Pitt M (2016). Opening the black box: Combining agent based simulation and realism in intervention development.
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Opening the black box: Combining agent based simulation and realism in intervention development
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Chalk D, Manzi S (2016). THe hospital discharge game : a game theory-inspired workshop to encourage cooperation between health and social care organisations.
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THe hospital discharge game : a game theory-inspired workshop to encourage cooperation between health and social care organisations
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