Dr Robin Beaumont
Research Fellow
R.Beaumont@exeter.ac.uk
RILD Building Level 3
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK
Overview
I am a Research Fellow in the Genetics of Complex Traits Group. My main area of research is on development of analysis methods to understand the maternal and foetal genetic contributions to birth weight. A key area of my work is performing large-scale genome wide association studies (GWAS) and meta-analysis within the Early Growth Genetics (EGG) consortium which has resulted in publications in Nature (2016), Nature Genetics (2019) and Human Molecular Genetics (2018) and has identified 190 regions of the genome with are robustly associated with birth weight.
Links
- Early Growth Genetics (EGG) Consortium
- Genetics of Complex Traits Group, University of Exeter Medical School
Publications
Journal articles
Beaumont RN, Mayne IK, Freathy R, Wright C (In Press). Common genetic variants with fetal effects on birth weight are enriched for proximity to genes implicated in rare developmental disorders. Human Molecular Genetics
Beaumont R, Kotecha SJ, Wood AR, Knight BA, Sebert S, McCarthy MI, Hattersley AT, Järvelin M-R, Timpson NJ, Freathy RM, et al (In Press). Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies. PLoS Genetics Abstract.
Oram RA, Weedon M, Wood A, Beaumont R, Tyrrell J (In Press). Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident
Diagnosis. Diabetes Care
Jones SE, van Hees VT, Mazzotti DR, Marques-Vidal P, Sabia S, van der Spek A, Dashti HS, Engmann J, Kocevska D, Tyrrell J, et al (In Press). Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Nature Communications Abstract.
Freathy RM, Beaumont RN, Horikoshi M, McCarthy MI (In Press). How can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?. Current Diabetes Reports
Green H, Weedon M (In Press). Hyperglycemia is a causal risk factor for upper limb pathologies. International Journal of Epidemiology Abstract.
Wright C, Tuke M, Frayling T, Weedon M, Murray A, Tyrrell J, Ruth K, Beaumont R, Wood A (In Press). Large copy number variants in UK Biobank caused by clonal haematopoiesis may confound penetrance estimates. American Journal of Human Genetics
Kingdom R, Tuke M, Wood A, Beaumont R, Frayling T, Weedon M, Wright C (In Press). Rare genetic variants in genes and loci linked to dominant monogenic developmental disorders cause milder related phenotypes in the general population. American Journal of Human Genetics Abstract.
D'Urso S, Moen G-H, Hwang L-D, Hannigan LJ, Corfield EC, Ask H, Johannson S, Njølstad PR, Beaumont RN, Freathy RM, et al (2024). Intrauterine Growth and Offspring Neurodevelopmental Traits: a Mendelian Randomization Analysis of the Norwegian Mother, Father and Child Cohort Study (MoBa). JAMA Psychiatry, 81(2), 144-156. Abstract. Author URL.
Thompson WD, Reynolds RM, Beaumont RN, Warrington NM, Tyrrell J, Wood AR, Evans DM, McDonald TJ, Hattersley AH, Freathy RM, et al (2024). Maternal plasma cortisol's effect on offspring birth weight: a Mendelian Randomisation study. BMC Pregnancy Childbirth, 24(1). Abstract. Author URL.
Solé-Navais P, Flatley C, Steinthorsdottir V, Vaudel M, Juodakis J, Chen J, Laisk T, LaBella AL, Westergaard D, Bacelis J, et al (2023). Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight. Nat Genet, 55(7). Author URL.
Casanova F, O'Loughlin J, Karageorgiou V, Beaumont RN, Bowden J, Wood AR, Tyrrell J (2023). Effects of physical activity and sedentary time on depression, anxiety and well-being: a bidirectional Mendelian randomisation study. BMC Med, 21(1). Abstract. Author URL.
McBride N, Fernández-Sanlés A, Arab MA, Bond TA, Zheng J, Magnus MC, Corfield EC, Clayton GL, Hwang L-D, Beaumont RN, et al (2023). Effects of the maternal and fetal proteome on birth weight: a Mendelian randomization analysis. medRxiv Abstract. Author URL.
Solé-Navais P, Flatley C, Steinthorsdottir V, Vaudel M, Juodakis J, Chen J, Laisk T, LaBella AL, Westergaard D, Bacelis J, et al (2023). Genetic effects on the timing of parturition and links to fetal birth weight. Nat Genet, 55(4), 559-567. Abstract. Author URL.
Hawkes G, Beaumont RN, Tyrrell J, Power GM, Wood A, Laakso M, Fernandes Silva L, Boehnke M, Yin X, Richardson TG, et al (2023). Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood. Diabetologia, 66(8), 1472-1480. Abstract. Author URL.
Harlow CE, Patel VV, Waterworth DM, Wood AR, Beaumont RN, Ruth KS, Tyrrell J, Oguro-Ando A, Chu AY, Frayling TM, et al (2023). Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk. Hum Mol Genet, 32(3), 496-505. Abstract. Author URL.
Beaumont RN, Flatley C, Vaudel M, Wu X, Chen J, Moen G-H, Skotte L, Helgeland Ø, Solé-Navais P, Banasik K, et al (2023). Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics, 55(11), 1807-1819. Abstract.
Hawkes G, Yengo L, Vedantam S, Marouli E, Beaumont RN, GIANT Consortium, Tyrrell J, Weedon MN, Hirschhorn J, Frayling TM, et al (2023). Identification and analysis of individuals who deviate from their genetically-predicted phenotype. PLoS Genet, 19(9). Abstract. Author URL.
Hawkes G, Yengo L, Vedantam S, Marouli E, Beaumont RN, GIANT Consortium, Tyrrell J, Weedon MN, Hirschhorn J, Frayling TM, et al (2023). Identification and analysis of individuals who deviate from their genetically-predicted phenotype. bioRxiv Abstract. Author URL.
Ruth KS, Beaumont RN, Locke JM, Tyrrell J, Crandall CJ, Hawkes G, Frayling TM, Prague JK, Patel KA, Wood AR, et al (2023). Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records. BMC Med Genomics, 16(1). Abstract. Author URL.
Decina CS, Hopkins R, Bowden J, Shields BM, Lawlor DA, Warrington NM, Evans DM, Freathy RM, Beaumont RN (2023). Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study. Int J Epidemiol, 52(1), 178-189. Abstract. Author URL.
Shekari S, Stankovic S, Gardner EJ, Hawkes G, Kentistou KA, Beaumont RN, Mörseburg A, Wood AR, Prague JK, Mishra GD, et al (2023). Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency. Nat Med, 29(7), 1692-1699. Abstract. Author URL.
Haulder M, Hughes AE, Beaumont RN, Knight BA, Hattersley AT, Shields BM, Freathy RM (2022). Assessing whether genetic scores explain extra variation in birthweight, when added to clinical and anthropometric measures. BMC Pediatrics, 22(1). Abstract.
Nongmaithem SS, Beaumont RN, Dedaniya A, Wood AR, Ogunkolade B-W, Hassan Z, Krishnaveni GV, Kumaran K, Potdar RD, Sahariah SA, et al (2022). Babies of South Asian and European Ancestry Show Similar Associations with Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns. Diabetes, 71(4), 821-836. Abstract. Author URL.
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Correction: Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2022). Corrigendum to: a genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Human Molecular Genetics, 31(9).
Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS, Wood AR, Beaumont RN, et al (2022). Detection and characterization of male sex chromosome abnormalities in the UK Biobank study. Genet Med, 24(9), 1909-1919. Abstract. Author URL.
Martin S, Tyrrell J, Thomas EL, Bown MJ, Wood AR, Beaumont RN, Tsoi LC, Stuart PE, Elder JT, Law P, et al (2022). Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation. eLife, 11 Abstract.
Beaumont RN, Wright CF (2022). Estimating diagnostic noise in panel-based genomic analysis. Genet Med, 24(10), 2042-2050. Abstract. Author URL.
Vogelezang S, Bradfield JP, Vogelezang S, Bradfield JP, Johansson S, Stergiakouli E, Thiering E, Pennell CE, Ahluwalia TS, Karhunen V, et al (2022). Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. BMC Medical Genomics, 15(1). Abstract.
Harlow CE, Gandawijaya J, Bamford RA, Martin E-R, Wood AR, van der Most PJ, Tanaka T, Leonard HL, Etheridge AS, Innocenti F, et al (2022). Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic predictor for EPO-increasing therapies. Am J Hum Genet, 109(9), 1638-1652. Abstract. Author URL.
Pervjakova N, Moen G-H, Borges M-C, Ferreira T, Cook JP, Allard C, Beaumont RN, Canouil M, Hatem G, Heiskala A, et al (2022). Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes. Hum Mol Genet, 31(19), 3377-3391. Abstract. Author URL.
Cannon S, Clissold R, Sukcharoen K, Tuke M, Hawkes G, Beaumont RN, Wood AR, Gilchrist M, Hattersley AT, Oram RA, et al (2022). Recurrent 17q12 microduplications contribute to renal disease but not diabetes. Journal of Medical Genetics, 60(5), 491-497. Abstract.
Mirshahi UL, Colclough K, Wright CF, Wood AR, Beaumont RN, Tyrrell J, Laver TW, Stahl R, Golden A, Goehringer JM, et al (2022). Reduced penetrance of MODY-associated HNF1A/HNF4A variants but not GCK variants in clinically unselected cohorts. Am J Hum Genet, 109(11), 2018-2028. Abstract. Author URL.
Weedon MN, Jones SE, Lane JM, Lee J, Ollila HM, Dawes A, Tyrrell J, Beaumont RN, Partonen T, Merikanto I, et al (2022). The impact of Mendelian sleep and circadian genetic variants in a population setting. PLoS Genet, 18(9). Abstract. Author URL.
Cresswell M, Casanova F, Beaumont RN, Wood AR, Ronan N, Hilton MP, Tyrrell J (2022). Understanding Factors That Cause Tinnitus: a Mendelian Randomization Study in the UK Biobank. Ear Hear, 43(1), 70-80. Abstract. Author URL.
Nongmaithem SS, Beaumont RN, Dedaniya A, Wood AR, Ogunkolade B-W, Hassan Z, Krishnaveni GV, Kumaran K, Potdar RD, Sahariah SA, et al (2021). Associations of genetic scores for birth weight with newborn size and later Anthropometric traits and cardiometabolic risk markers in South Asians. Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens DM, Knight BA, Evans DM, et al (2021). Fetal alleles predisposing to metabolically favorable adiposity are associated with higher birth weight. Human Molecular Genetics, 31(11), 1762-1775. Abstract.
Martin S, Cule M, Basty N, Tyrrell J, Beaumont RN, Wood AR, Frayling TM, Sorokin E, Whitcher B, Liu Y, et al (2021). Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease. Diabetes, 70(8), 1843-1856. Abstract. Author URL.
Ruth K, Beaumont RN, Frayling TM, Joaquim MDR, Shekari S, Tyrrell J, Wood AR, Murray A (2021). Genetic insights into biological mechanisms governing human ovarian ageing. Nature Abstract.
Tyrrell J, Zheng J, Beaumont R, Hinton K, Richardson TG, Wood AR, Davey Smith G, Frayling TM, Tilling K (2021). Genetic predictors of participation in optional components of UK Biobank. Nat Commun, 12(1). Abstract. Author URL.
Heald AH, Martin S, Fachim H, Green HD, Young KG, Malipatil N, Siddals K, Cortes G, Tyrrell J, Wood AR, et al (2021). Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile. Diabetic Medicine, 38(9). Abstract.
Casanova F, O'Loughlin J, Martin S, Beaumont RN, Wood AR, Watkins ER, Freathy RM, Hagenaars SP, Frayling TM, Yaghootkar H, et al (2021). Higher adiposity and mental health: causal inference using Mendelian randomization. Hum Mol Genet, 30(24), 2371-2382. Abstract. Author URL.
Moen G-H, Beaumont RN, Grarup N, Sommer C, Shields BM, Lawlor DA, Freathy RM, Evans DM, Warrington NM (2021). Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight. Int J Epidemiol, 50(1), 179-189. Abstract. Author URL.
Anderson EL, Richmond RC, Jones SE, Hemani G, Wade KH, Dashti HS, Lane JM, Wang H, Saxena R, Brumpton B, et al (2021). Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis. Int J Epidemiol, 50(3), 817-828. Abstract. Author URL.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2021). Mendelian randomization to investigate the link between TSH and thyroid cancer. Endocrine-Related Cancer, 28(9), L11-L14. Abstract.
O'Loughlin J, Casanova F, Jones SE, Hagenaars SP, Beaumont RN, Freathy RM, Watkins ER, Vetter C, Rutter MK, Cain SW, et al (2021). Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health. Mol Psychiatry, 26(11), 6305-6316. Abstract. Author URL.
Casanova F, Wood AR, Yaghootkar H, Beaumont RN, Jones SE, Gooding KM, Aizawa K, Strain WD, Hattersley AT, Khan F, et al (2020). A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function. Diabetes, 69(5), 1072-1082. Abstract. Author URL.
Duckworth A, Gibbons MA, Beaumont RN, Wood AR, Almond H, Lunnon K, Lindsay MA, Scotton CJ, Tyrrell J (2020). A Mendelian randomisation study of smoking causality in IPF compared with COPD. Abstract.
Green HD, Jones A, Evans JP, Wood AR, Beaumont RN, Tyrrell J, Frayling TM, Smith C, Weedon MN (2020). A genome wide association study of frozen shoulder identifies a common variant of <i>WNT7B</i> and diabetes as causal risk factors. Abstract.
Sharp SA, Jones SE, Kimmitt RA, Weedon MN, Halpin AM, Wood AR, Beaumont RN, King S, van Heel DA, Campbell PM, et al (2020). A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care. Alimentary Pharmacology & Therapeutics, 52(7), 1165-1173. Abstract.
Lin S, Green HD, Hendy P, Heerasing NM, Chanchlani N, Hamilton B, Walker GJ, Heap GA, Hobart J, Martin RJ, et al (2020). Clinical Features and Genetic Risk of Demyelination Following Anti-TNF Treatment. J Crohns Colitis, 14(12), 1653-1661. Abstract. Author URL.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Does Obesity Cause Thyroid Cancer? a Mendelian Randomization Study. J Clin Endocrinol Metab, 105(7), e2398-e2407. Abstract. Author URL.
Duckworth A, Gibbons MA, Allen RJ, Almond H, Beaumont RN, Wood AR, Lunnon K, Lindsay MA, Wain LV, Tyrrell J, et al (2020). Evidence that Telomere Length is Causal for Idiopathic Pulmonary Fibrosis but not Chronic Obstructive Pulmonary Disease: a Mendelian Randomisation Study. Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (2020). Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight. Abstract.
Green HD, Beaumont RN, Wood AR, Hamilton B, Jones SE, Goodhand JR, Kennedy NA, Ahmad T, Yaghootkar H, Weedon MN, et al (2020). Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study. International Journal of Epidemiology, 49(4), 1270-1281. Abstract.
Thompson WD, Beaumont RN, Kuang A, Warrington NM, Ji Y, Tyrrell J, Wood AR, Scholtens D, Knight BA, Evans DM, et al (2020). Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile. Abstract.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). Mendelian randomization supports a causative effect of TSH on thyroid carcinoma. Endocr Relat Cancer, 27(10), 551-559. Abstract. Author URL.
Vogelezang S, Bradfield JP, Ahluwalia TS, Curtin JA, Lakka TA, Grarup N, Scholz M, van der Most PJ, Monnereau C, Stergiakouli E, et al (2020). Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet, 16(10). Abstract. Author URL.
Fussey JM, Beaumont RN, Wood AR, Vaidya B, Smith J, Tyrrell J (2020). RETRACTION: Mendelian randomization supports a causative effect of TSH on thyroid carcinoma. Endocr Relat Cancer, 27(11). Author URL.
Schnurr TM, Morgen CS, Borisevich D, Beaumont RN, Engelbrechtsen L, Ängquist L, Have CT, Freathy RM, Smith GD, Nohr EA, et al (2020). The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood. Sci Rep, 10(1). Abstract. Author URL.
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, et al (2020). Using human genetics to understand the disease impacts of testosterone in men and women. Nature Medicine, 26(2), 252-258.
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, et al (2019). A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio. Hum Mol Genet, 28(24), 4197-4207. Abstract. Author URL.
Wright CF, West B, Tuke M, Jones SE, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Frayling TM, et al (2019). Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting. American Journal of Human Genetics, 104(2), 275-286. Abstract.
Thompson WD, Tyrrell J, Borges MC, Beaumont RN, Knight BA, Wood AR, Ring SM, Hattersley AT, Freathy RM, Lawlor DA, et al (2019). Association of maternal circulating 25(OH)D and calcium with birth weight: a mendelian randomisation analysis. PLoS Medicine, 16
Lane JM, Jones SE, Dashti HS, Wood AR, Aragam KG, van Hees VT, Strand LB, Winsvold BS, Wang H, Bowden J, et al (2019). Biological and clinical insights from genetics of insomnia symptoms. Nature Genetics Abstract.
Howe LD, Kanayalal R, Beaumont RN, Davies AR, Frayling TM, Harrison S, Jones SE, Sassi F, Wood AR, Tyrrell J, et al (2019). Effects of body mass index on relationship status, social contact, and socioeconomic position: Mendelian Randomization study in UK Biobank. Abstract.
Kwasniok F, Beaumont R, Thuburn J (2019). Erratum to Vortex dynamics of stratospheric sudden warmings: a reanalysis data study using PV contour integral diagnostics (Quarterly Journal of the Royal Meteorological Society, (2019), 145, 720, (1013-1033), 10.1002/qj.3474). Quarterly Journal of the Royal Meteorological Society, 145(724). Abstract.
Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modasli E, Celis-Morales C, Ferguson L, Vie G, Palmer T, Fritsche L, et al (2019). Evidence of a causal relationship between body mass index and psoriasis: a mendelian randomization study. PLoS Medicine
Bovijn J, Jackson L, Censin J, Chen CY, Laisk T, Laber S, Ferreira T, Pulit SL, Glastonbury CA, Smoller JW, et al (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104(1), 157-163. Abstract.
Green HD, Beaumont RN, Thomas A, Hamilton B, Wood AR, Sharp S, Jones SE, Tyrrell J, Walker G, Goodhand J, et al (2019). Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis. J Crohns Colitis, 13(12), 1578-1582. Abstract. Author URL.
Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, Staiger H, Thomas EL, Atabaki-Pasdar N, Campbell A, Tyrrell J, Jones SE, et al (2019). Genome-Wide and Abdominal MRI Data Provide Evidence That a Genetically Determined Favorable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease, and Hypertension. Diabetes, 68(1), 207-219. Abstract. Author URL.
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, et al (2019). Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms. Nature Communications Abstract.
Schafmayer C, Harrison JW, Buch S, Lange C, Reichert MC, Hofer P, Cossais F, Kupcinskas J, von Schönfels W, Schniewind B, et al (2019). Genome-wide association analysis of diverticular disease points towards neuromuscular, connective tissue and epithelial pathomechanisms. Gut, 68(5), 854-865. Abstract. Author URL.
Dashti HS, Jones SE, Wood AR, Lane JM, van Hees VT, Wang H, Rhodes JA, Song Y, Patel K, Anderson SG, et al (2019). Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates. Nat Commun, 10(1). Abstract. Author URL.
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S, Hao K, Feenstra B, et al (2019). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet, 51(5), 804-814. Abstract. Author URL.
Pulit SL, Stoneman C, Morris AP, Wood AR, Glastonbury CA, Tyrrell J, Yengo L, Ferreira T, Marouli E, Ji Y, et al (2019). Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. Hum Mol Genet, 28(1), 166-174. Abstract. Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Mosaic Turner syndrome shows reduced penetrance in an adult population study. Genet Med, 21(4), 877-886. Abstract. Author URL.
Tuke MA, Ruth KS, Wood AR, Beaumont RN, Tyrrell J, Jones SE, Yaghootkar H, Turner CLS, Donohoe ME, Brooke AM, et al (2019). Response to Prakash et al. Genet Med, 21(8), 1884-1885. Author URL.
Kikas T, Rull K, Beaumont RN, Freathy RM, Laan M (2019). The Effect of Genetic Variation on the Placental Transcriptome in Humans. Frontiers in Genetics
Middeldorp CM, Felix JF, Mahajan A, McCarthy MI (2019). The early growth genetics (Egg) and early genetics and lifecourse epidemiology (eagle) consortia: Design, results and future prospects. European Journal of Epidemiology, 34(3), 279-300. Abstract.
Tyrrell J, Mulugeta A, Wood AR, Zhou A, Beaumont RN, Tuke MA, Jones SE, Ruth KS, Yaghootkar H, Sharp S, et al (2019). Using genetics to understand the causal influence of higher BMI on depression. Int J Epidemiol, 48(3), 834-848. Abstract. Author URL.
Liu X, Helenius D, Skotte L, Beaumont RN, Wielscher M, Geller F, Juodakis J, Mahajan A, Bradfield JP, Lin FTJ, et al (2019). Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration. Nat Commun, 10(1). Abstract. Author URL.
Kwasniok F, Beaumont R, Thuburn J (2019). Vortex dynamics of stratospheric sudden warmings: a reanalysis data study using PV contour integral diagnostics. Quarterly Journal of the Royal Meteorological Society, 145(720), 1013-1033. Abstract.
Frayling TM (2018). A Common Allele in FGF21 Associated with Sugar Intake is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure. Cell Reports, 23(2), 327-336.
Hughes AE, Nodzenski M, Beaumont RN, Talbot O, Shields BM, Scholtens DM, Knight BA, Lowe WL, Hattersley AT, Freathy RM, et al (2018). Fetal Genotype and Maternal Glucose Have Independent and Additive Effects on Birth Weight. Diabetes, 67(5), 1024-1029. Abstract. Author URL.
Nielsen JB, Fritsche LG, Zhou W, Teslovich TM, Holmen OL, Gustafsson S, Gabrielsen ME, Schmidt EM, Beaumont R, Wolford BN, et al (2018). Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. Am J Hum Genet, 102(1), 103-115. Abstract. Author URL.
Beaumont RN, Warrington NM, Cavadino A, Tyrrell J, Nodzenski M, Horikoshi M, Geller F, Myhre R, Richmond RC, Paternoster L, et al (2018). Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet, 27(4), 742-756. Abstract. Author URL.
Warrington NM, Richmond R, Fenstra B, Myhre R, Gaillard R, Paternoster L, Wang CA, Beaumont RN, Das S, Murcia M, et al (2018). Maternal and fetal genetic contribution to gestational weight gain. Int J Obes (Lond), 42(4), 775-784. Abstract. Author URL.
Macé A, Tuke MA, Deelen P, Kristiansson K, Mattsson H, Nõukas M, Sapkota Y, Schick U, Porcu E, Rüeger S, et al (2017). CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits. Nat Commun, 8(1). Abstract. Author URL.
Tyrrell J, Wood AR, Ames RM, Yaghootkar H, Beaumont RN, Jones SE, Tuke MA, Ruth KS, Freathy RM, Davey Smith G, et al (2017). Gene-obesogenic environment interactions in the UK Biobank study. Int J Epidemiol, 46(2), 559-575. Abstract. Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid A, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2017). Quantifying the extent to which index event biases influence large genetic association studies. Hum Mol Genet, 26(5), 1018-1030. Abstract. Author URL.
Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo C-L, Ruth KS, Tuke MA, Yaghootkar H, et al (2017). Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. PLoS One, 12(9). Abstract. Author URL.
Beaumont R, Kwasniok F, Thuburn J (2017). Vortex erosion in a shallow water model of the polar vortex. Dynamics of Atmospheres and Oceans, 78, 137-151.
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A, Tuke MA, Hayward C, et al (2016). Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Diabetes, 65(8), 2448-2460. Abstract. Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Jones SE, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Weedon MN, Frayling TM, et al (2016). Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health. Hum Reprod, 31(2), 473-481. Abstract. Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Hu Y, Teder-Laving M, Hayward C, et al (2016). Genome-wide association analyses in 128,266 individuals identifies new morningness and sleep duration loci. PLoS Genetics
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, et al (2016). Genome-wide associations for birth weight and correlations with adult disease. Nature, 538(7624), 248-252. Abstract. Author URL.
Frayling TM, Tyrrell J, Jones SE, Beaumont R, Astley CM, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, et al (2016). Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank. British Medical Journal
Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016). Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY), 8(3), 547-560. Abstract. Author URL.
Wood AR, Tyrrell J, Beaumont R, Jones SE, Tuke MA, Ruth KS, GIANT consortium, Yaghootkar H, Freathy RM, Murray A, et al (2016). Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. Diabetologia, 59(6), 1214-1221. Abstract. Author URL.
Conferences
Beaumont R, Wright C (2023). Estimating diagnostic noise in panel-based genomic analysis. Author URL.
McBride N, Fernandes-Sanles A, Al-Arab M, Zheng J, Beaumont RN, Bond T, Gaunt T, Freathy R, Lawlor DA, Borges MC, et al (2023). Exploring the effects of the maternal and fetal proteome on birth weight. Author URL.
McBride N, Fernandes-Sanles A, Al-Arab M, Zheng J, Beaumont RN, Bond T, Gaunt T, Freathy R, Lawlor DA, Borges MC, et al (2023). Exploring the effects of the maternal and fetal proteome on birth weight. Author URL.
Hughes AE, Kuang A, Lim B, Fore R, Hatem G, Allard C, Morris AP, Lawlor DA, Beaumont RN, Lowe WLJ, et al (2022). A multi-ancestry genome-wide association study of umbilical cord insulin and c-peptide levels will form the basis of an important future bioresource. Author URL.
McBride N, Fernandez-Sanles A, Al Arab M, Beaumont RN, Zheng CJ, Gaunt T, Bond T, Freathy RM, Lawlor DA, Borges MC, et al (2022). Exploring the Effects of the Maternal and Fetal Proteome on Birthweight: a Mendelian Randomization Study. Author URL.
Hughes AE, Lim B, Beaumont RN, Hattersley AT, Lawlor DA, Freathy RM (2022). Fetal genetics is a critical determinant of fetal growth that is independent of maternal glucose and fetal insulin in individuals of South Asian ancestry. Author URL.
Haulder MH, Hughes AEH, Beaumont RNB, Lim BL, Leirer DL, Hattersley ATH, Shields BMS, Freathy RMF (2022). Lower birthweight of South Asian babies compared with Europeans is not explained by variation in contributions of a fetal genetic score, maternal glycemia or other basic maternal characteristics. Author URL.
Patel K, Mirshahi U, Colclough K, Wright C, Wood A, Beaumont R, Laver T, Stahl R, Golden A, Goehringer J, et al (2022). Penetrance of MODY is substantially lower in clinically unselected cohort: important implications for opportunistic genomic testing. Author URL.
Haulder M, Hughes AE, Beaumont RN, Knight BA, Hattersley AT, Shields BM, Freathy RM (2021). Genetic scores explain variation in birthweight that is not captured by measured clinical variables such as maternal glucose. Author URL.
Casanova F, Jones S, O'Loughlin J, Beaumont R, Wood A, Bowden J, Tyrrell J (2021). PHYSICAL ACTIVITY AND MENTAL HEALTH: a MENDELIAN RANDOMIZATION STUDY. Author URL.
Sharp S, Jones S, Kimmitt R, Weedon M, Halpin A, Wood A, King S, Beaumont R, Hagopian W, Turner J, et al (2019). DEVELOPMENT AND CLINICAL VALIDATION OF a GENETIC RISK SCORE FOR COELIAC DISEASE. Author URL.
Tyrrell J, Mulugeta A, Wood A, Zhou A, Beaumont R, Tuke M, Jones S, Ruth K, Yaghootkar H, Lewis C, et al (2019). DOES HIGH BMI IN THE ABSENCE OF METABOLIC CONSEQUENCES CAUSE DEPRESSION?. Author URL.
Sharp SA, Jones SE, Kimmitt RA, Weedon MN, Halpin A, Wood AR, King S, Beaumont RN, Hagopian WA, Turner JM, et al (2019). Development of a genetic risk score for coeliac disease and validation in a clinical diagnostic setting. Author URL.
Ruth KS, Beaumont RN, Tyrrell J, Wood AR, Jones SE, Weedon MN, Frayling TM, Murray A (2019). Genetic signals for use of hormone replacement therapy in post-menopausal women suggest potential drug targets and reflect changes in health practice. Author URL.
Kikas T, Rull K, Beaumont RN, Freathy RM, Laan M (2019). Human placental expression quantitative trait loci (eQTL) identified among genetic variants linked to complex traits and disease susceptibility. Author URL.
Green H, Beaumont R, Jones S, Yaghootkar H, Wood A, Goodhand J, Kennedy N, Ahmad T, Frayling T, Weedon M, et al (2019). MODIFIABLE RISK FACTORS FOR GASTRO-OESOPHAGAL REFLUX DISEASE: a MENDELIAN RANDOMISATION STUDY. Author URL.
Wright CF, Tuke MA, West B, Jones S, Patel K, Laver TW, Beaumont RN, Tyrrell J, Wood AR, Murray A, et al (2019). Using UK Biobank to assess the pathogenicity, penetrance and expressivity of monogenic disease variants. Author URL.
Tyrrell J, Yaghootkar H, Jones SE, Beaumont R, Wood AR, Tuke MA, Ruth KS, Andrews RC, Frayling TM (2018). Broad changes in body mass index between age 10 and adulthood are associated with type 2 diabetes risk independently of adult body mass index. Author URL.
Yaghootkar H, Ji Y, Yiorkas AM, Tyrrell J, Jones SE, Beaumont R, Wood AR, Blakemore AIF, Bell JD, Frayling TM, et al (2018). Carrying more 'favourable adiposity' genetic factors is associated with higher adiposity but lower ectopic fat and lower risk of Type 2 diabetes. Author URL.
Yaghootkar H, Ji Y, Yiorkas AM, Frau F, Mook-Kanamori D, De Mutsert R, Tyrrell J, Jones SE, Beaumont R, Wood AR, et al (2018). Genome-Wide and Abdominal Imaging Data Characterizes Common Alleles Associated with Higher BMI and Subcutaneous Fat but Less Liver Fat and Lower Risk of Type 2 Diabetes. Author URL.
Beaumont RN, Warrington NM, Horikoshi M, Day FR, Ong KK, McCarthy MI, Perry JRB, Freathy RM, Evans DM (2018). Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic disease. Author URL.
Wood AR, Jones SE, Richmond R, Ahmad S, Yaghootkar H, Beaumont R, Ruth KS, Tuke M, Murray A, Freathy RM, et al (2018). Physical Inactivity and Sleep Inefficiency Accentuate the Genetic Risk of Obesity. Author URL.
Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Birth weight is not just influenced by maternal glycaemia: there is an independent effect of fetal genetics, which has a similar impact to maternal fasting plasma glucose. Author URL.
Hughes AE, Beaumont RN, Knight BA, Shields B, Freathy RM, Hattersley AT (2017). Fetal genetics impacts on risk of macrosomia independently of maternal hyperglycaemia. Author URL.
Yaghootkar H, Ji Y, Tyrrell J, Jones SE, Beaumont R, Tuke MA, Ruth KS, Freathy RM, Wood AR, Murray A, et al (2017). Identification of alleles associated with higher body fat percentage but lower risk of type 2 diabetes. Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames RM, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). Gene-obesogenic environment interactions in the UK Biobank study. Author URL.
Yaghootkar H, Lotta L, Tyrrell J, Smit R, Jones S, Donnelly L, Beaumont R, Campbell A, Tuke M, Hayward C, et al (2016). Genetic Evidence for a Link between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease. Author URL.
Jones SE, Tyrrell J, Wood AR, Beaumont R, Ruth K, Tuke M, Yaghootkar H, Teder-Laving M, Hayward C, Roenneberg T, et al (2016). Genetic Studies of Sleep and Morningness and Their Relationship with Obesity and Type 2 Diabetes. Author URL.
Tyrrell J, Yaghootkar H, Beaumont R, Jones SE, Ames R, Tuke MA, Ruth KS, Kutalik Z, Freathy RM, Murray A, et al (2016). High Risk Obesogenic Environments Accentuate Genetic Susceptibility to Obesity. Author URL.
Tyrrell J, Jones SE, Beaumont R, Astley C, Lovell R, Yaghootkar H, Tuke M, Ruth KS, Freathy RM, Hirschhorn JN, et al (2016). Higher BMI Leads to Lower Socioeconomic Status: a Mendelian Randomisation Study in the UK Biobank. Author URL.
Yaghootkar H, Bancks MP, Jones SE, McDaid AF, Beaumont R, Donnelly L, Wood AR, Campbell A, Tyrrell J, Hocking LJ, et al (2016). Quantifying the Extent to Which Index Event Biases Influence Large Genetic Association Studies. Author URL.
Horikoahi M, Day FR, Perry JRB, Hottenga J-J, Li-Gao R, Beaumont R, Warrington NM, Timpson NJ (2015). Large scale genome-wide association study for birth weight identifies 13 novel loci and reveals genetic links with a variety of adult metabolic and anthropometric traits. Author URL.
