University of Exeter Medical School

Professor Paul Winyard

Professor Paul Winyard

Professor (E&R)

 P.G.Winyard@exeter.ac.uk

 2919

 +44 (0) 1392 722919

 Medical School Building G12

 

Medical School Building, St Luke's Campus, Magdalen Road, Exeter, EX1 2LU, UK

Overview

Qualifications

BSc (Hons) Biochemistry, Cardiff University, Wales

MSc Chemistry, University of Gothenburg, Sweden

PhD Chemical Pathology, University of Birmingham, England

Links

Research group links

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Publications

Books

Jacob C, Kirsch G, Slusarenko A, Winyard PG, Burkholz T (2014). Recent advances in redox active plant and microbial products: from basic chemistry to widespread applications in medicine and agriculture. Abstract.
Whiteman M, Moore PK (eds)(2009). Is hydrogen sulfide a regulator of nitric oxide bioavailability in the vasculature?. Weinheim, Germany, Wiley-VCH.
Jacob C (2009). Redox Signaling and Regulation in Biology and Medicine. Weinheim, Germany, Wiley-VCH.
Winyard PG, Willoughby DA (2003). Inflammation Protocols., Humana Press.
Winyard PG, Blake DR, Evans CH (2000). Free radicals and inflammation., Birkhäuser. Abstract.
Blake D, Winyard PG (1995). Immunopharmacology of free radical species., Academic Pr. Abstract.

Journal articles

Jordan JB, Smallwood MJ, Smerdon GR, Winyard PG (2024). Cellular Pre-Adaptation to the High O2 Concentration Used in Standard Cell Culture Confers Resistance to Subsequent H2O2-Induced Cell Death. Antioxidants, 13(3), 269-269. Abstract.
Kyriakou S, Demosthenous N, Amery T, Stewart KJ, Winyard PG, Franco R, Pappa A, Panayiotidis MI (2024). Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via its N-Acetylated Cysteine Conjugated form in Malignant Melanoma. Antioxidants, 13(1), 82-82. Abstract.
Owen EJ, Heylen RA, Stewart K, Winyard PG, Jenkins ATA (2024). The multi-factorial modes of action of urease in the pathogenesis of incontinence associated dermatitis. Skin Health and Disease Abstract.
Kyriakou S, Potamiti L, Demosthenous N, Amery T, Stewart K, Winyard PG, Franco R, Pappa A, Panayiotidis MI (2023). A Naturally Derived Watercress Flower-Based Phenethyl Isothiocyanate-Enriched Extract Induces the Activation of Intrinsic Apoptosis via Subcellular Ultrastructural and Ca2+ Efflux Alterations in an in Vitro Model of Human Malignant Melanoma. Nutrients, 15(18). Abstract.  Author URL.
Strollo R, Vinci C, Man YKS, Bruzzaniti S, Piemonte E, Alhamar G, Briganti SI, Malandrucco I, Tramontana F, Fanali C, et al (2023). Autoantibody and T cell responses to oxidative post-translationally modified insulin neoantigenic peptides in type 1 diabetes. Diabetologia, 66(1), 132-146. Abstract.  Author URL.
Owen EJ, Heylen RA, Stewart K, Winyard PG, Jenkins ATA (2023). Detecting and monitoring incontinence associated dermatitis: Does impedance spectroscopy have a part to play?. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 095441192311591-095441192311591. Abstract.
L’Heureux JE, van der Giezen M, Winyard PG, Jones AM, Vanhatalo A (2023). Localisation of nitrate-reducing and highly abundant microbial communities in the oral cavity. PLOS ONE, 18(12), e0295058-e0295058. Abstract.
Tabish TA, Crabtree MJ, Townley HE, Winyard PG, Lygate CA (2023). Nitric Oxide Releasing Nanomaterials for Cardiovascular Applications. JACC Basic to Translational Science
Cocksedge SP, Causer AJ, Winyard PG, Jones AM, Bailey SJ (2023). Oral Temperature and pH Influence Dietary Nitrate Metabolism in Healthy Adults. Nutrients, 15(3), 784-784. Abstract.
Wei C, Vanhatalo A, Kadach S, Stoyanov Z, Abu-Alghayth M, Black MI, Smallwood MJ, Rajaram R, Winyard PG, Jones AM, et al (2023). Reduction in blood pressure following acute dietary nitrate ingestion is correlated with increased red blood cell S-nitrosothiol concentrations. Nitric Oxide, 138-139, 1-9. Abstract.  Author URL.
Kyriakou S, Tragkola V, Alghol H, Anestopoulos I, Amery T, Stewart K, Winyard PG, Trafalis DT, Franco R, Pappa A, et al (2022). Evaluation of Bioactive Properties of Lipophilic Fractions of Edible and Non-Edible Parts of Nasturtium officinale (Watercress) in a Model of Human Malignant Melanoma Cells. Pharmaceuticals, 15(2). Abstract.
McGrattan AM, Stephan BCM, Shannon OM, Mazidi M, Gilchrist M, Smallwood M, Winyard P, McMahon N, Blekkenhorst LC, Mohan D, et al (2022). Independent and interactive associations of dietary nitrate and salt intake with blood pressure and cognitive function: a cross-sectional analysis in the InCHIANTI study. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 73(4), 491-502.  Author URL.
Nice R, Goodhand JR, Kennedy N, Ahmad T, Winyard P, McDonald TJ (2022). P196 Pre-treatment antibodies to infliximab and adalimumab are common but are not associated with anti-TNF treatment failure. Journal of Crohn's and Colitis, 16(Supplement_1), i256-i256.
Kyriakou S, Michailidou K, Amery T, Stewart K, Winyard PG, Trafalis DT, Franco R, Pappa A, Panayiotidis MI (2022). Polyphenolics, glucosinolates and isothiocyanates profiling of aerial parts of Nasturtium officinale (Watercress). Frontiers in Plant Science, 13
Hajibandeh S, Hajibandeh S, Marshall MJ, Smart NJ, Winyard PG, Hyde C, Shaw AM, Daniels IR (2021). Biomarkers for diagnosis of acute appendicitis in adults. Cochrane Database of Systematic Reviews, 2021(10). Abstract.
Vanhatalo A, L'Heureux JE, Kelly J, Blackwell JR, Wylie LJ, Fulford J, Winyard PG, Williams DW, van der Giezen M, Jones AM, et al (2021). Network analysis of nitrate-sensitive oral microbiome reveals interactions with cognitive function and cardiovascular health across dietary interventions. Redox Biology, 41, 101933-101933.
Abu-Alghayth M, Vanhatalo A, Wylie LJ, McDonagh STJ, Thompson C, Kadach S, Kerr P, Smallwood MJ, Jones AM, Winyard PG, et al (2021). S-nitrosothiols, and other products of nitrate metabolism, are increased in multiple human blood compartments following ingestion of beetroot juice. Redox Biology, 43, 101974-101974.
Riddell A, Kirkwood J, Smallwood M, Winyard P, Knight B, Steer K, Puddicombe L, Romanczuk L, Shore A, Gilchrist M, et al (2020). P1612CAN THE URINARY NITRATE TO CREATININE RATIO BE USED AS a MARKER FOR KIDNEY TRANSPLANT REJECTION?. Nephrology Dialysis Transplantation, 35(Supplement_3).
Williams JK, Smallwood MJ, Benjamin N, D'Souza RJ, Shore AC, Winyard PG, Gilchrist M (2020). Renal nitrate clearance in chronic kidney disease. Nitric Oxide, 97, 16-19.
Riddell A, Kirkwood J, Smallwood M, Winyard P, Knight B, Romanczuk L, Shore A, Gilchrist M (2020). Urinary nitrate concentration as a marker for kidney transplant rejection. BMC Nephrol, 21(1). Abstract.  Author URL.
Tabish TA, Pranjol MZI, Horsell D, Rahat A, Whatmore JL, Winyard PG, Zhang S (2019). Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As a Novel Anti-Metastatic Enzyme Cancer Therapy. Cancers, 3, 1-20.
Knight AR, Taylor EL, Lukaszewski R, Jensen KT, Jones HE, Carré JE, Isupov MN, Littlechild JA, Bailey SJ, Brewer E, et al (2018). A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells. Free Radical Biology and Medicine, 120, 246-254. Abstract.
Ferguson DCJ, Smerdon GR, Harries LW, Dodd NJF, Murphy MP, Curnow A, Winyard PG (2018). Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia. Free Radical Biology and Medicine, 126, 322-333. Abstract.
Ali M, Tabish TA, Scotton C, Ferguson D, Liangxu L, Veen A, Lowry S, Jabeen F, Ali M, Winyard P, et al (2018). Biocompatibility and toxicity of graphene quantum dots for potential application in photodynamic therapy. Nanomedicine, 1-16.
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, et al (2018). Corrigendum to “European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)” (Redox Biol. (2017) 13 (94–162)(S2213231717303373)(10.1016/j.redox.2017.05.007)). Redox Biology, 14, 694-696. Abstract.
Tabish TA, Zhang S, Winyard PG (2018). Developing the next generation of graphene-based platforms for cancer therapeutics: the potential role of reactive oxygen species. Redox Biology, 15, 34-40. Abstract.
Tabish TA, Lin L, Ali M, Jabeen F, Iqbal R, Horsell DW, Winyard PG, Zhang S (2018). Investigating the bioavailability of graphene quantum dots in lung tissues via fourier transform infrared spectroscopy. Interface Focus, 8(3). Abstract.
Tabish TA, Pranjol MZI, Jabeen F, Abdullah T, Latif A, Khalid A, Ali M, Hayat H, Winyard PG, Whatmore JL, et al (2018). Investigation into the toxic effects of graphene nanopores on lung cancer cells and biological tissues. Applied Materials Today, 12, 389-401. Abstract.
Dewhurst-Trigg R, Yeates T, Blackwell JR, Thompson C, Linoby A, Morgan PT, Clarke I, Connolly LJ, Wylie LJ, Winyard PG, et al (2018). Lowering of blood pressure after nitrate-rich vegetable consumption is abolished with the co-ingestion of thiocyanate-rich vegetables in healthy normotensive males. Nitric Oxide - Biology and Chemistry, 74, 39-46. Abstract.
Vanhatalo A, Blackwell JR, L'Heureux JE, Williams DW, Smith A, van der Giezen M, Winyard PG, Kelly J, Jones AM (2018). Nitrate-responsive oral microbiome modulates nitric oxide homeostasis and blood pressure in humans. Free Radical Biology and Medicine, 124, 21-30. Abstract.
Smallwood MJ, Nissim A, Knight AR, Whiteman M, Haigh R, Winyard PG (2018). Oxidative stress in autoimmune rheumatic diseases. Free Radical Biology and Medicine, 125, 3-14. Abstract.
Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, et al (2017). European contribution to the study of ROS: a summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biology, 13, 94-162. Abstract.
Smyth E, Solomon A, Birrell MA, Smallwood MJ, Winyard PG, Tetley TD, Emerson M (2017). Influence of inflammation and nitric oxide upon platelet aggregation following deposition of diesel exhaust particles in the airways. British Journal of Pharmacology, 174(13), 2130-2139. Abstract.
Bailey SJ, Blackwell JR, Wylie LJ, Emery A, Taylor E, Winyard PG, Jones AM (2017). Influence of iodide ingestion on nitrate metabolism and blood pressure following short-term dietary nitrate supplementation in healthy normotensive adults. Nitric Oxide, 63, 13-20. Abstract.  Author URL.
Szabó-Taylor K, Tóth E, Balogh AM, Sódar BW, Kádár L, Pálóczi K, Fekete N, Németh A, Osteikoetxea X, Vukman KV, et al (2017). Monocyte activation drives preservation of membrane thiols by promoting release of oxidised membrane moieties via extracellular vesicles. Free Radical Biology and Medicine, 108, 56-65. Abstract.
Smallwood MJ, Ble A, Melzer D, Winyard PG, Benjamin N, Shore AC, Gilchrist M (2017). Relationship between urinary nitrate excretion and blood pressure in the in Chianti Cohort. American Journal of Hypertension, 30(7), 707-712. Abstract.
Smyth E, Solomon A, Birrell MA, Smallwood MJ, Winyard PG, Tetley TD, Emerson M (2017). Response to ‘Effects of diesel exhaust particles on coagulation’. British Journal of Pharmacology, 174(22).
FALK K, JOVALL P, WINYARD P (2016). ChemInform Abstract: PROTON NMR STUDIES OF a TETRASACCHARIDE WHICH IS a RECEPTOR FOR UROPATHOGENIC E. COLI BACTERIA. ChemInform, 14(3), no-no.
Shepherd AI, Wilkerson DP, Fulford J, Winyard PG, Benjamin N, Shore AC, Gilchrist M (2016). Effect of nitrate supplementation on hepatic blood flow and glucose homeostasis: a double-blind, placebo-controlled, randomized control trial. Am J Physiol Gastrointest Liver Physiol, 311(3), G356-G364. Abstract.  Author URL.
Bailey SJ, Blackwell JR, Wylie LJ, Holland T, Winyard PG, Jones AM (2016). Improvement in blood pressure after short-term inorganic nitrate supplementation is attenuated in cigarette smokers compared to non-smoking controls. Nitric Oxide, 61, 29-37. Abstract.  Author URL.
Dogra Y, Ferguson DCJ, Dodd NJF, Smerdon GR, Curnow A, Winyard PG (2016). The hydroxypyridinone iron chelator CP94 increases methyl-aminolevulinate-based photodynamic cell killing by increasing the generation of reactive oxygen species. Redox Biol, 9, 90-99. Abstract.  Author URL.
Bailey SJ, Blackwell JR, Williams E, Vanhatalo A, Wylie LJ, Winyard PG, Jones AM (2016). Two weeks of watermelon juice supplementation improves nitric oxide bioavailability but not endurance exercise performance in humans. Nitric Oxide, 59, 10-20.
Siervo M, Lara J, Jajja A, Sutyarjoko A, Ashor AW, Brandt K, Qadir O, Mathers JC, Benjamin N, Winyard PG, et al (2015). Ageing modifies the effects of beetroot juice supplementation on 24-hour blood pressure variability: an individual participant meta-analysis. Nitric Oxide, 47, 97-105. Abstract.  Author URL.
Marshall MJ, Smart NJ, Hyde C, Winyard PG, Shaw AM, Daniels IR (2015). Biomarkers for diagnosis of acute appendicitis in adults. COCHRANE DATABASE OF SYSTEMATIC REVIEWS(3).  Author URL.
Ahmed U, Anwar A, Savage RS, Costa ML, Mackay N, Filer A, Raza K, Watts RA, Winyard PG, Tarr J, et al (2015). Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health. Sci Rep, 5 Abstract.  Author URL.
Harvey HM, Gross AJ, Brooksby P, Downard AJ, Green SJ, Winlove CP, Benjamin N, Winyard PG, Whiteman M, Hammond JL, et al (2015). Boron-Doped Diamond Dual-Plate Deep-Microtrench Device for Generator-Collector Sulfide Sensing. Electroanalysis, 27(11), 2645-2653. Abstract.
Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R, Cheng D, Knight AR, Taylor EL, Oettrich J, Ruskovska T, et al (2015). Clinical Relevance of Biomarkers of Oxidative Stress. Antioxid Redox Signal, 23(14), 1144-1170. Abstract.  Author URL.
Wightman EL, Haskell-Ramsay CF, Thompson KG, Blackwell JR, Winyard PG, Forster J, Jones AM, Kennedy DO (2015). Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Physiol Behav, 149, 149-158. Abstract.  Author URL.
Shepherd AI, Gilchrist M, Winyard PG, Jones AM, Hallmann E, Kazimierczak R, Rembialkowska E, Benjamin N, Shore AC, Wilkerson DP, et al (2015). Effects of dietary nitrate supplementation on the oxygen cost of exercise and walking performance in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled crossover trial. Free Radic Biol Med, 86, 200-208. Abstract.  Author URL.
Bailey SJ, Blackwell JR, Lord T, Vanhatalo A, Winyard PG, Jones AM (2015). L-Citrulline supplementation improves O<inf>2</inf> uptake kinetics and high-intensity exercise performance in humans. Journal of Applied Physiology, 119(4), 385-395. Abstract.
James PE, Willis GR, Allen JD, Winyard PG, Jones AM (2015). Nitrate pharmacokinetics: Taking note of the difference. Nitric Oxide, 48, 44-50. Abstract.  Author URL.
Gross AJ, Holmes S, Dale SEC, Smallwood MJ, Green SJ, Peter Winlove C, Benjamin N, Winyard PG, Marken F (2015). Nitrite/nitrate detection in serum based on dual-plate generator-collector currents in a microtrench. Talanta, 131, 228-235. Abstract.
Affourtit C, Bailey SJ, Jones AM, Smallwood MJ, Winyard PG (2015). On the mechanism by which dietary nitrate improves human skeletal muscle function. Front Physiol, 6 Abstract.  Author URL.
Taylor EL, Armstrong KR, Perrett D, Hattersley AT, Winyard PG (2015). Optimisation of an advanced oxidation protein products assay: its application to studies of oxidative stress in diabetes mellitus. Oxidative Medicine and Cellular Longevity, 2015 Abstract.
Szabó-Taylor K, Ryan B, Osteikoetxea X, Szabó TG, Sódar B, Holub M, Németh A, Pálóczi K, Pállinger É, Winyard P, et al (2015). Oxidative and other posttranslational modifications in extracellular vesicle biology. Seminars in Cell and Developmental Biology, 40, 8-16. Abstract.
Szabó-Taylor K, Ryan B, Osteikoetxea X, Szabó TG, Sódar B, Holub M, Németh A, Pálóczi K, Pállinger É, Winyard P, et al (2015). Oxidative and other posttranslational modifications in extracellular vesicle biology. Semin Cell Dev Biol, 40, 8-16. Abstract.  Author URL.
McDonagh STJ, Wylie LJ, Winyard PG, Vanhatalo A, Jones AM (2015). The Effects of Chronic Nitrate Supplementation and the Use of Strong and Weak Antibacterial Agents on Plasma Nitrite Concentration and Exercise Blood Pressure. Int J Sports Med, 36(14), 1177-1185. Abstract.  Author URL.
Shepherd AI, Wilkerson DP, Dobson L, Kelly J, Winyard PG, Jones AM, Benjamin N, Shore AC, Gilchrist M (2015). The effect of dietary nitrate supplementation on the oxygen cost of cycling, walking performance and resting blood pressure in individuals with chronic obstructive pulmonary disease: a double blind placebo controlled, randomised control trial. Nitric Oxide, 48, 31-37. Abstract.  Author URL.
Burska AN, Hunt L, Boissinot M, Strollo R, Ryan BJ, Vital E, Nissim A, Winyard PG, Emery P, Ponchel F, et al (2014). Autoantibodies to posttranslational modifications in rheumatoid arthritis. Mediators Inflamm, 2014 Abstract.  Author URL.
Hammond JL, Gross AJ, Estrela P, Iniesta J, Green SJ, Winlove CP, Winyard PG, Benjamin N, Marken F (2014). Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor. Anal Chem, 86(14), 6748-6752. Abstract.  Author URL.
Vanhatalo A, Jones AM, Blackwell JR, Winyard PG, Fulford J (2014). Dietary nitrate accelerates postexercise muscle metabolic recovery and O2 delivery in hypoxia. J Appl Physiol (1985), 117(12), 1460-1470. Abstract.  Author URL.
Gilchrist M, Winyard PG, Fulford J, Anning C, Shore AC, Benjamin N (2014). Dietary nitrate supplementation improves reaction time in type 2 diabetes: development and application of a novel nitrate-depleted beetroot juice placebo. Nitric Oxide, 40, 67-74. Abstract.  Author URL.
Kelly J, Vanhatalo A, Bailey SJ, Wylie LJ, Tucker C, List S, Winyard PG, Jones AM (2014). Dietary nitrate supplementation: effects on plasma nitrite and pulmonary O2 uptake dynamics during exercise in hypoxia and normoxia. Am J Physiol Regul Integr Comp Physiol, 307(7), R920-R930. Abstract.
Lo Faro ML, Fox B, Whatmore JL, Winyard PG, Whiteman M (2014). Hydrogen sulfide and nitric oxide interactions in inflammation. Nitric Oxide, 41, 38-47. Abstract.  Author URL.
Kirkham PA, Whiteman M, Winyard PG, Caramori G, Gordon F, Ford PA, Barnes PJ, Adcock IM, Chung KF (2014). Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD. Eur Respir J, 43(5), 1504-1506.  Author URL.
Ryan BJ, Nissim A, Winyard PG (2014). Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases. Redox Biol, 2, 715-724. Abstract.  Author URL.
Apostoli GL, Solomon A, Smallwood MJ, Winyard PG, Emerson M (2014). Role of inorganic nitrate and nitrite in driving nitric oxide-GMP-mediated inhibition of platelet aggregation <i>in vitro</i> and <i>in vivo</i>. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 12(11), 1880-1889.  Author URL.
Le Trionnaire S, Perry A, Szczesny B, Szabo C, Winyard PG, Whatmore JL, Wood ME, Whiteman M (2014). The synthesis and functional evaluation of a mitochondria-targeted hydrogen sulfide donor, (10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl) triphenylphosphonium bromide (AP39). MedChemComm, 5(6), 728-736. Abstract.
Strollo R, Ponchel F, Malmström V, Rizzo P, Bombardieri M, Wenham CY, Landy R, Perret D, Watt F, Corrigall VM, et al (2013). Autoantibodies to posttranslationally modified type II collagen as potential biomarkers for rheumatoid arthritis. Arthritis and Rheumatism, 65(7), 1702-1712.
Wylie LJ, Kelly J, Bailey SJ, Blackwell JR, Skiba PF, Winyard PG, Jeukendrup AE, Vanhatalo A, Jones AM (2013). Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985), 115(3), 325-336. Abstract.  Author URL.
Eggleton P, Nissim A, Ryan BJ, Whiteman M, Winyard PG (2013). Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens. Free Radic Biol Med, 57, 79-91. Abstract.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Eggleton P, Smerdon GR (2013). Different oxygen treatment pressures alter inflammatory gene expression in human endothelial cells. Undersea and Hyperbaric Medicine, 40(2), 115-123. Abstract.
Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin N (2013). Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes. Free Radic Biol Med, 60, 89-97. Abstract.  Author URL.
Kelly J, Fulford J, Vanhatalo A, Blackwell JR, French O, Bailey SJ, Gilchrist M, Winyard PG, Jones AM (2013). Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults. Am J Physiol Regul Integr Comp Physiol, 304(2), R73-R83. Abstract.  Author URL.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Kendall AC, Whatmore JL, Winyard PG, Smerdon GR, Eggleton P (2013). Hyperbaric oxygen treatment reduces neutrophil-endothelial adhesion in chronic wound conditions through S-nitrosation. Wound Repair and Regeneration, 21(6), 860-868. Abstract.
Fulford J, Winyard PG, Vanhatalo A, Bailey SJ, Blackwell JR, Jones AM (2013). Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions. Pflugers Archiv European Journal of Physiology, 465(4), 517-528. Abstract.
Fulford J, Winyard PG, Vanhatalo A, Bailey SJ, Blackwell JR, Jones AM (2013). Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions. Pflugers Arch, 465(4), 517-528. Abstract.  Author URL.
Li L, Fox B, Keeble J, Salto-Tellez M, Winyard PG, Wood ME, Moore PK, Whiteman M (2013). The complex effects of the slow-releasing hydrogen sulfide donor GYY4137 in a model of acute joint inflammation and in human cartilage cells. J Cell Mol Med, 17(3), 365-376. Abstract.  Author URL.
Marut W, Jamier V, Kavian N, Servettaz A, Eggleton P, Winyard PG, Anwar A, Nicco C, Jacob C, Chéreau C, et al (2013). The natural organosulfur compound dipropyltetrasulfide prevents HOCL-induced systemic sclerosis in the mouse. Arthritis Research and Therapy Abstract.
Akcay YD, Sagin FG, Aksu K, Keser G, Taylor E, Knight I, Winyard PG, Sozmen EY (2012). A panel of oxidative stress assays does not provide supplementary diagnostic information in Behcet's disease patients. Journal of Inflammation, 9 Abstract.
Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing. FREE RADICAL BIOLOGY AND MEDICINE, 53, S127-S127.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Ferguson D, Eggleton P (2012). Different oxygen treatment pressures alter oxygen responses and redox signalling gene expression in human endothelial cells. FREE RADICAL BIOLOGY AND MEDICINE, 53, S166-S166.  Author URL.
Fox B, Schantz J-T, Haigh R, Wood ME, Moore PK, Viner N, Spencer JPE, Winyard PG, Whiteman M (2012). Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?. J Cell Mol Med, 16(4), 896-910. Abstract.  Author URL.
Szabó-Taylor K, Eggleton P, Turner CAL, Lo Faro ML, Tarr JM, Tóth S, Whiteman M, Haigh RC, Littlechild JA, Winyard PG, et al (2012). Lymphocytes from rheumatoid arthritis patients have elevated levels of intracellular peroxiredoxin 2, and a greater frequency of cells with exofacial peroxiredoxin 2, compared with healthy human lymphocytes. The International Journal of Biochemistry and Cell Biology, 44(8), 1223-1231. Abstract.
Stamp LK, Khalilova I, Tarr JM, Senthilmohan R, Turner R, Haigh RC, Winyard PG, Kettle AJ (2012). Myeloperoxidase and oxidative stress in rheumatoid arthritis. Rheumatology (Oxford), 51(10), 1796-1803. Abstract.  Author URL.
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil NM, Amarrelli A, Al-Kashi A, Winyard PG, Chernajovsky Y, et al (2012). Targeting therapeutics to arthritic joints by antibody specific to post-translationally modified collagen type II. Annals of the Rheumatic Diseases, 71(Suppl 1), A7.2-A7.
Bailey SJ, Vanhatalo A, Winyard PG, Jones AM (2012). The nitrate-nitrite-nitric oxide pathway: its role in human exercise physiology. European Journal of Sport Science, 12(4), 309-320. Abstract.
Subang MC, Fatah R, Bright C, Blanco P, Berenstein M, Wu Y, Podhajcer OL, Winyard PG, Chernajovsky Y, Gould D, et al (2011). A novel hybrid promoter responsive to pathophysiological and pharmacological regulation. Journal of Molecular Medicine, 1-11.
Lansley KE, Winyard PG, Bailey SJ, Vanhatalo A, Wilkerson DP, Blackwell JR, Gilchrist M, Benjamin N, Jones AM (2011). Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc, 43(6), 1125-1131. Abstract.  Author URL.
Winyard PG, Spickett CM, Griffiths HR (2011). Analysis of radicals and radical reaction products in cell signalling and biomolecular damage: the long hard road to gold-standard measures. Biochem Soc Trans, 39(5), 1217-1220. Abstract.  Author URL.
Kendall AC, Whatmore JL, Harries LW, Winyard PG, Smerdon GR, Eggleton P (2011). Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions. Experimental Cell Research Abstract.
Vanhatalo A, Fulford J, Bailey SJ, Blackwell JR, Winyard PG, Jones AM (2011). Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia. Journal of Physiology Abstract.
Lansley KE, Winyard PG, Fulford J, Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Gilchrist M, Benjamin N, Jones AM, et al (2011). Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study. J Appl Physiol (1985), 110(3), 591-600. Abstract.  Author URL.
Eggleton P, Bremer E, Tarr J, De Bruyn M, Helfrich W, Kendall K, Haigh R, Viner N, Winyard PG (2011). Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects. Arthritis research and therapy
Eggleton P, Bremer E, Tarr JM, de Bruyn M, Helfrich W, Kendall A, Haigh RC, Viner NJ, Winyard PG (2011). Frequency of Th17 CD20+ cells in the peripheral blood of rheumatoid arthritis patients is higher compared to healthy subjects. Arthritis Res Ther, 13(6). Abstract.  Author URL.
Whiteman M, Winyard PG (2011). Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising. Expert Reviews in Clinical Pharmacology, 4, 13-32. Abstract.
Bailey SJ, Winyard PG, Blackwell JR, Vanhatalo A, Lansley KE, Dimenna FJ, Wilkerson DP, Campbell IT, Jones AM (2011). Influence of N-acetylcysteine administration on pulmonary O₂ uptake kinetics and exercise tolerance in humans. Respir Physiol Neurobiol, 175(1), 121-129. Abstract.  Author URL.
Winyard PG, Ryan B, Eggleton P, Nissim A, Taylor E, Lo Faro ML, Burkholz T, Szabó-Taylor KE, Fox B, Viner N, et al (2011). Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans, 39(5), 1226-1232. Abstract.  Author URL.
Haskell CF, Thompson K, Jones AM, Blackwell JR, Winyard PG, Forster J, Kennedy DO (2011). Nitrate-rich beetroot juice modulates cerebral blood flow and cognitive performance in humans. Appetite, 57(2), 560-560.
Jones AM, Bailey SJ, Vanhatalo A, Fulford J, Gilchrist M, Benjamin N, Winyard PG (2011). Reply to Lundberg, Larsen, and Weitzberg. J Appl Physiol (1985), 111(2).  Author URL.
Schneider T, Baldauf A, Ba LA, Jamier V, Khairan K, Sarakbi M-B, Reum N, Schneider M, Röseler A, Becker K, et al (2011). Selective antimicrobial activity associated with sulfur nanoparticles. J Biomed Nanotechnol, 7(3), 395-405. Abstract.  Author URL.
Winyard PG (2010). A Mechanism of Release of Calreticulin from Cells During Apoptosis. JOURNAL OF MOLECULAR BIOLOGY, 401, 799-812.
Tarr JM, Young PJ, Morse R, Shaw DJ, Haigh R, Petrov PG, Johnson SJ, Winyard PG, Eggleton P (2010). A mechanism of release of calreticulin from cells during apoptosis. J Mol Biol, 401(5), 799-812. Abstract.
Bailey SJ, Winyard PG, Vanhatalo A, Blackwell JR, DiMenna FJ, Wilkerson DP, Jones AM (2010). Acute L-arginine supplementation reduces the O2 cost of moderate-intensity exercise and enhances high-intensity exercise tolerance. J Appl Physiol (1985), 109(5), 1394-1403. Abstract.  Author URL.
Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM (2010). Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol, 299(4), R1121-R1131. Abstract.  Author URL.
Eggleton P, Harries L, Alberigo G, Wordsworth P, Viner N, Haigh R, Donnelly S, Jones H, Chikanza I, O Conner T, et al (2010). Changes in Apoptotic Gene Expression in Lymphocytes from Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Compared with Healthy Lymphocytes. Journal of Clinical Immunology, 30, 649-658-649-658.
Eggleton P, Harries LW, Alberigo G, Wordsworth P, Viner N, Haigh R, Donnelly S, Jones HW, O Conner TWE, Thomson AER, et al (2010). Changes in apoptotic gene expression in lymphocytes from rheumatoid arthritis and systemic lupus erythematosus patients compared with healthy lymphocytes. Journal of Clinical Immunology, 30(5), 649-658. Abstract.
Whiteman M, Haigh R, Tarr JM, Gooding KM, Shore AC, Winyard PG (2010). Detection of hydrogen sulfide in plasma and knee-joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation. Ann N Y Acad Sci, 1203, 146-150. Abstract.  Author URL.
Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM (2010). Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol (1985), 109(1), 135-148. Abstract.  Author URL.
Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM (2010). Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. (vol 109, pg 135, 2010). JOURNAL OF APPLIED PHYSIOLOGY, 109(3), 943-943.  Author URL.
Gilchrist M, Winyard PG, Benjamin N (2010). Dietary nitrate--good or bad?. Nitric Oxide, 22(2), 104-109. Abstract.  Author URL.
Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM (2010). Errtum: Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans (Journal of Applied Physiology (2010) 109 (135-148)). Journal of Applied Physiology, 109(3).
Tarr JM, Winyard PG (2010). Extracellular Calreticulin is Present in the Joints of Patients with Rheumatoid Arthritis and Inhibits FasL (CD95L)-Mediated Apoptosis of T Cells. Arthritis and Rheumatism, 62, 2919-2929.
Tarr JM, Winyard PG, Ryan B, Harries LW, Haigh R, Viner N, Eggleton P (2010). Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)-mediated apoptosis of T cells. Arthritis Rheum, 62(10), 2919-2929. Abstract.  Author URL.
Hughes C, Faurholm B, Dell Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D, Subang C, Al-Kashi A, et al (2010). Human single-chain variable fragment that specifically targets arthritic cartilage. Arthritis & Rheumatism, 62, 1007-1016.
Whiteman M, Winyard PG (2010). Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising. Expert Rev Clin Pharmacol, 4(1).
Whiteman M, Haigh R, Haas M, Moore PK, Gooding KM, Shore AC, Winyard PG (2010). Hydrogen sulphide and clinical indices of inflammation in rheumatoid arthritis. Ann NY Acad Sci
Holmgren A (2010). Redox Signaling and Regulation in Biology and Medicine. Edited by Claus Jacob and Paul G. Winyard. ChemBioChem, 11(3), 436-436.
Benjamin N, Bailey SJ, Vanhatalo A, Winyard P, Jones AM (2009). Beware of the pickle: health effects of nitrate intake Reply. JOURNAL OF APPLIED PHYSIOLOGY, 107(5), 1678-1678.  Author URL.
Whiteman M, Dogra Y, Winyard PG, Armstrong JS (2009). Detection and measurement of reactive oxygen intermediates in mitochondria and cells. Methods Mol Biol, 476, 28-49. Abstract.  Author URL.
Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM (2009). Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol (1985), 107(4), 1144-1155. Abstract.  Author URL.
Shaw FL, Winyard PG, Smerdon GR, Bryson PJ, Moody AJ, Eggleton P (2009). Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules. Clin Biochem, 42(6), 467-476. Abstract.  Author URL.
Benjamin N, Bailey SJ, Vanhatalo A, Winyard P, Jones AM (2009). Reply to Derave and Taes. Journal of Applied Physiology, 107(5).
(2009). Rheumatoid Arthritis - Aetiopathogenesis and Animal Models [20-36]. Rheumatology, 48(Supplement 1), i35-i40.
Curnow A, Dogra Y, Winyard PG, Campbell S (2009). Using iron chelating agents to enhance dermatological PDT.
Akcaya YD, Knight IA, Taylor EL, Aksuc K, Winyard PG (2008). Assessment of plasma S-nitrosothiol concentration by electron paramagnetic resonance spectrometry and plasma nitrotyrosine levels by ELISA in Behcet's disease. Journal of the International Federation of Clinical Chemistry, 18(4).
Eggleton P, Haigh R, Winyard PG (2008). Consequence of neo-antigenicity of the 'altered self'. Rheumatology (Oxford), 47(5), 567-571. Abstract.  Author URL.
Winyard PG, Knight IA, Shaw FL, Rocks SA, Davies CA, Eggleton P, Haigh R, Whiteman M, Benjamin N (2008). Determination of S-nitrosothiols in biological and clinical samples using electron paramagnetic resonance spectrometry with spin trapping. Methods Enzymol, 441, 151-160. Abstract.  Author URL.
Pattison DJ, Winyard PG (2008). Dietary antioxidants in inflammatory arthritis: do they have any role in etiology or therapy?. Nature Reviews Rheumatology, 4(11), 590-596. Abstract.  Author URL.
Glantzounis GK, Rocks SA, Sheth H, Knight I, Salacinski HJ, Davidson BR, Winyard PG, Seifalian AM (2007). Formation and role of plasma S-nitrosothiols in liver ischemia-reperfusion injury. Free Radic Biol Med, 42(6), 882-892. Abstract.  Author URL.
Holley JE, Newcombe J, Winyard PG, Gutowski NJ (2007). Peroxiredoxin V in multiple sclerosis lesions: predominant expression by astrocytes. Mult Scler, 13(8), 955-961. Abstract.  Author URL.
Christen S, Cattin I, Knight I, Winyard PG, Blum JW, Elsasser TH (2007). Plasma S-nitrosothiol status in neonatal calves: ontogenetic associations with tissue-specific S-nitrosylation and nitric oxide synthase. Exp Biol Med (Maywood), 232(2), 309-322. Abstract.  Author URL.
PWinyard, Glantzounis G, Knight I, Rocks S (2007). The increased formation of S-nitrosothiols following liver ischaemia-reperfusion injury. Free Radical Biology and Medicine, 42(6), 882-892.
Jacob C, Knight I, Winyard PG (2006). Aspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways. Biol Chem, 387(10-11), 1385-1397.
Jacob C, Knight I, Winyard PG (2006). Aspects of the biological redox chemistry of cysteine: from simple redox responses to sophisticated signalling pathways. Biol Chem, 387(10-11), 1385-1397. Abstract.  Author URL.
Tarr JM, Eggleton P, Winyard PG (2006). Nitric oxide and the regulation of apoptosis in tumour cells. Curr Pharm Des, 12(34), 4445-4468. Abstract.  Author URL.
Young P, Szestakowska D, Morse R, Winyard PG, Eggleton P, Johnson S (2006). Purification of human native and recombinant domains of calreticulin: structural and functional implications. Calcium Binding Proteins, 1, 160-169.
O'Shaughnessy MC, Vetsika E-K, Inglis JJ, Carleson J, Haigh R, Kidd BL, Winyard PG (2006). The effect of substance P on nitric oxide release in a rheumatoid arthritis model. Inflamm Res, 55(6), 236-240. Abstract.  Author URL.
PWinyard, Corrigall V, Fatah R, Nissim A (2005). Generation of neoantigenic epitopes after posttranslational modification of type II collagen by factors present within the inflamed joint. Arthritis & Rheumatism, 52(12), 3829-3838.
Nissim A, Winyard PG, Corrigall V, Fatah R, Perrett D, Panayi G, Chernajovsky Y (2005). Generation of neoantigenic epitopes after posttranslational modification of type II collagen by factors present within the inflamed joint. Arthritis Rheum, 52(12), 3829-3838. Abstract.  Author URL.
PWinyard, Davies C, Hicks S, Rocks S (2005). Measurement of S-nitrosothiols in extracellular fluids from healthy human volunteers and rheumatoid arthritis patients, using electron paramagnetic resonance spectrometry. Free Radical Biology and Medicine, 39(7), 937-948.
Rocks SA, Davies CA, Hicks SL, Webb AJ, Klocke R, Timmins GS, Johnston A, Jawad ASM, Blake DR, Benjamin N, et al (2005). Measurement of S-nitrosothiols in extracellular fluids from healthy human volunteers and rheumatoid arthritis patients, using electron paramagnetic resonance spectrometry. Free Radic Biol Med, 39(7), 937-948. Abstract.  Author URL.
Winyard PG, Moody CJ, Jacob C (2005). Oxidative activation of antioxidant defence. Trends Biochem Sci, 30(8), 453-461. Abstract.  Author URL.
Guo R, D'Cruz D, Rocks S, Alba P, Ferro L, Winyard PG (2003). AN OXIDANT IN THE SERUM AND URINE FROM PATIENTS WITH CONNECTIVE TISSUE DISEASES. RHEUMATOLOGY, 42, 78-78.  Author URL.
Dai L, Claxson A, Marklund SL, Feakins R, Yousaf N, Chernajovsky Y, Winyard PG (2003). Amelioration of antigen-induced arthritis in rats by transfer of extracellular superoxide dismutase and catalase genes. Gene Ther, 10(7), 550-558. Abstract.  Author URL.
Davies CA, Rocks SA, O'Shaughnessy MC, Perrett D, Winyard PG (2003). Analysis of nitrite and nitrate in the study of inflammation. Methods Mol Biol, 225, 305-320.  Author URL.
Petropoulou P, Zhang Z, Curtis MA, Johnson NW, Hughes FJ, Winyard PG (2003). Measurement of both native and inactivated forms of alpha1 proteinase inhibitor in human inflammatory extracellular fluids. J Clin Periodontol, 30(9), 795-801. Abstract.  Author URL.
Hamilton L, Nielsen BR, Davies CA, Symons MCR, Winyard PG (2003). Purity of different preparations of sodium 3,5-dibromo-4-nitrosobenzenesulphonate and their applicability for EPR spin trapping. Free Radic Res, 37(1), 41-49. Abstract.  Author URL.
Chernajovsky Y, Winyard PG, Kabouridis PS (2002). Advances in understanding the genetic basis of rheumatoid arthritis and osteoarthritis: implications for therapy. Am J Pharmacogenomics, 2(4), 223-234. Abstract.  Author URL.
Harris MN, Burchiel SW, Winyard PG, Engen JR, Mobarak CD, Timmins GS (2002). Determining the site of spin trapping of the equine myoglobin radical by combined use of EPR, electrophoretic purification, and mass spectrometry. Chem Res Toxicol, 15(12), 1589-1594. Abstract.  Author URL.
Rocks SA, Scott G, Symons MCR, Winyard PG (2002). ELECTRON PARAMAGNETIC RESONANCE SPECTROMETRY OF HIGH SPIN IRON (III) IN OSTEOARTHRITIC SYNOVIUM. RHEUMATOLOGY, 41, 124-124.  Author URL.
Guo R, Davies CA, Nielsen BR, Hamilton L, Symons MCR, Winyard PG (2002). Reaction of the spin trap 3,5-dibromo-4-nitrosobenzene sulfonate with human biofluids. Biochim Biophys Acta, 1572(1), 133-142. Abstract.  Author URL.
O'Shaughnessy MC, Vetsika E-K, Dai L, Scott G, Kidd BL, Winyard PG (2002). SUBSTANCE P INCREASES NITRIC OXIDE PRODUCTION IN HUMAN SYNOVIOCYTES. RHEUMATOLOGY, 41, 64-64.  Author URL.
Dai L, O'Shaughnessy MC, Gould D, Claxson A, Marklund S, Kidd B, Chernajovsky Y, Winyard PG (2002). SUPPRESSION OF INFLAMMATION BY ANTIOXIDANT GENE THERAPY IN AN ANTIGEN-INDUCED ARTHRITIS MODEL. RHEUMATOLOGY, 41, 34-34.  Author URL.
Davies CA, Klocke R, Rocks SA, Jawad ASM, Symons MCR, Blake DR, Winyard PG (2002). THE NITROSYLATION OF THIOLS IS ELEVATED IN RHEUMATOID ARTHRITIS. RHEUMATOLOGY, 41, 64-64.  Author URL.
Davies CA, Nielsen BR, Timmins G, Hamilton L, Brooker A, Guo R, Symons MC, Winyard PG (2001). Characterization of the radical product formed from the reaction of nitric oxide with the spin trap 3,5-dibromo-4-nitrosobenzene sulfonate. Nitric Oxide, 5(2), 116-127. Abstract.  Author URL.
Gilston V, Williams MA, Newland AC, Winyard PG (2001). Hydrogen peroxide and tumour necrosis factor-alpha induce NF-kappaB-DNA binding in primary human T lymphocytes in addition to T cell lines. Free Radic Res, 35(6), 681-691. Abstract.  Author URL.
Ellis L, Gilston V, Soo CC, Morris CJ, Kidd BL, Winyard PG (2000). Activation of the transcription factor NF-kappaB in the rat air pouch model of inflammation. Ann Rheum Dis, 59(4), 303-307. Abstract.  Author URL.
Dai L, Lamb DJ, Leake DS, Kus ML, Jones HW, Morris CJ, Winyard PG (2000). Evidence for oxidised low density lipoprotein in synovial fluid from rheumatoid arthritis patients. Free Radic Res, 32(6), 479-486. Abstract.  Author URL.
Ali NN, Gilston V, Winyard PG (1999). Activation of NF-kappaB in human osteoblasts by stimulators of bone resorption. FEBS Lett, 460(2), 315-320. Abstract.  Author URL.
Nazhat NB, Saadalla-Nazhat RA, Fairburn K, Jones P, Blake DR, Nielsen BR, Symons MC, Winyard PG (1999). Nitrite determination in human plasma and synovial fluid using reactions of nitric oxide with 3, 5-dibromo-4-nitrosobenzenesulphonate (DBNBS). Biochim Biophys Acta, 1427(2), 276-286. Abstract.  Author URL.
Davies CA, Perrett D, Zhang Z, Nielsen BR, Blake DR, Winyard PG (1999). Simultaneous analysis of nitrite, nitrate and the nicotinamide nucleotides by capillary electrophoresis: Application to biochemical studies and human extracellular fluids. Electrophoresis, 20(10), 2111-2117.
Davies CA, Perrett D, Zhang Z, Nielsen BR, Blake DR, Winyard PG (1999). Simultaneous analysis of nitrite, nitrate and the nicotinamide nucleotides by capillary electrophoresis: application to biochemical studies and human extracellular fluids. Electrophoresis, 20(10), 2111-2117. Abstract.  Author URL.
Zhang Z, Blake DR, Stevens CR, Kanczler JM, Winyard PG, Symons MC, Benboubetra M, Harrison R (1998). A reappraisal of xanthine dehydrogenase and oxidase in hypoxic reperfusion injury: the role of NADH as an electron donor. Free Radic Res, 28(2), 151-164. Abstract.  Author URL.
Zhang Z, Naughton D, Winyard PG, Benjamin N, Blake DR, Symons MCR (1998). Erratum: Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: a potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity (Biochemical and Biophysical Research Communications (1998) 249, 3 (767-772)). Biochemical and Biophysical Research Communications, 251(2).
Zhang Z, Naughton D, Winyard PG, Benjamin N, Blake DR, Symons MCR (1998). Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: a potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity (vol 249, pg 767, 1998). BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 251(2), 667-667.  Author URL.
Zhang Z, Naughton D, Winyard PG, Benjamin N, Blake DR, Symons MC (1998). Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: a potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity. Biochem Biophys Res Commun, 249(3), 767-772. Abstract.  Author URL.
Jones HW, Bailey R, Zhang Z, Dunne KA, Blake DR, Cox NL, Morris CJ, Winyard PG (1998). Inactivation of antithrombin III in synovial fluid from patients with rheumatoid arthritis. Ann Rheum Dis, 57(3), 162-165. Abstract.  Author URL.
Dai L, Zhang Z, Winyard PG, Gaffney K, Jones H, Blake DR, Morris CJ (1997). A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid. Free Radic Biol Med, 22(4), 705-710. Abstract.  Author URL.
Winyard PG, Blake DR (1997). Antioxidants, redox-regulated transcription factors, and inflammation. Adv Pharmacol, 38, 403-421.  Author URL.
Zhang Z, Naughton DP, Blake DR, Benjamin N, Stevens CR, Winyard PG, Symons MC, Harrison R (1997). Human xanthine oxidase converts nitrite ions into nitric oxide (NO). Biochem Soc Trans, 25(3).  Author URL.
Gilston V, Jones HW, Soo CC, Coumbe A, Blades S, Kaltschmidt C, Baeuerle PA, Morris CJ, Blake DR, Winyard PG, et al (1997). NF-kappa B activation in human knee-joint synovial tissue during the early stage of joint inflammation. Biochem Soc Trans, 25(3).  Author URL.
Montagnier L, Olivier R, Pasquier C (1997). Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases.
Edmonds SE, Winyard PG, Guo R, Kidd B, Merry P, Langrish-Smith A, Hansen C, Ramm S, Blake DR (1997). Putative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis. Results of a prospective placebo controlled double blind trial. Ann Rheum Dis, 56(11), 649-655. Abstract.  Author URL.
Blake DR, Stevens CR, Sahinoglu T, Ellis G, Gaffney K, Edmonds S, Benboubetra M, Harrison R, Jawed S, Kanczler J, et al (1997). Xanthine oxidase: four roles for the enzyme in rheumatoid pathology. Biochem Soc Trans, 25(3), 812-816.  Author URL.
Marok R, Winyard PG, Coumbe A, Kus ML, Gaffney K, Blades S, Mapp PI, Morris CJ, Blake DR, Kaltschmidt C, et al (1996). Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum, 39(4), 583-591. Abstract.  Author URL.
Winyard PG, Blake DR (1996). Antioxidants, Redox-Regulated Transcription Factors, and Inflammation. Advances in Pharmacology, 38(C), 403-421.
Dai L, Winyard PG, Zhang Z, Blake DR, Morris CJ (1996). Ascorbate promotes low density lipoprotein oxidation in the presence of ferritin. Biochim Biophys Acta, 1304(3), 223-228. Abstract.  Author URL.
Thorne SA, Abbot SE, Winyard PG, Blake DR, Mills PG (1996). Extent of oxidative modification of low density lipoprotein determines the degree of cytotoxicity to human coronary artery cells. Heart, 75(1), 11-16. Abstract.  Author URL.
Frears ER, Zhang Z, Blake DR, O'Connell JP, Winyard PG (1996). Inactivation of tissue inhibitor of metalloproteinase-1 by peroxynitrite. FEBS Lett, 381(1-2), 21-24. Abstract.  Author URL.
Thorne SA, Abbot SE, Stevens CR, Winyard PG, Mills PG, Blake DR (1996). Modified low density lipoprotein and cytokines mediate monocyte adhesion to smooth muscle cells. Atherosclerosis, 127(2), 167-176. Abstract.  Author URL.
Petropoulou P, Winyard PG, Zhang Z, Hughes FJ, Curtis MA, Johnson NW (1996). Molecular mechanisms of alpha 1-antitrypsin inactivation in chronic adult periodontitis. JOURNAL OF DENTAL RESEARCH, 75(5), 1154-1154.  Author URL.
Morris R, Winyard PG, Brass LF, Blake DR, Morris CJ (1996). Thrombin receptor expression in rheumatoid and osteoarthritic synovial tissue. Ann Rheum Dis, 55(11), 841-843. Abstract.  Author URL.
Lodge JK, Sadler PJ, Kus ML, Winyard PG (1995). Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. Biochim Biophys Acta, 1256(2), 130-140. Abstract.  Author URL.
Roselaar SE, Nazhat NB, Winyard PG, Jones P, Cunningham J, Blake DR (1995). Detection of oxidants in uremic plasma by electron spin resonance spectroscopy. Kidney Int, 48(1), 199-206. Abstract.  Author URL.
Harris G, Bashir S, Winyard PG (1994). 7,8-Dihydro-8-oxo-2'-deoxyguanosine present in DNA is not simply an artefact of isolation. Carcinogenesis, 15(2), 411-413. Abstract.  Author URL.
Winyard PG, Morris CJ, Winrow VR, Zaidi M, Blake DR (1994). Free radical pathways in the inflammatory response. , 28(C), 361-383.
Chidwick K, Zhang Z, Stanworth DR, Asmar G, Blake DR, Winyard PG (1994). Mechanisms of alpha 1-antitrypsin inactivation in arthritic joints: comment on the article by Abbink et al. Arthritis Rheum, 37(1), 150-151.  Author URL.
McKay IA, Winyard P, Leigh IM, Bustin SA (1994). Nuclear transcription factors: potential targets for new modes of intervention in skin disease. Br J Dermatol, 131(5), 591-597. Abstract.  Author URL.
Zhang Z, Winyard PG, Chidwick K, Murphy G, Wardell M, Carrell RW, Blake DR (1994). Proteolysis of human native and oxidised alpha 1-proteinase inhibitor by matrilysin and stromelysin. Biochim Biophys Acta, 1199(2), 224-228. Abstract.  Author URL.
Chidwick K, Whichelow CE, Zhang Z, Fairburn K, Sachs JA, Blake DR, Winyard PG (1994). Relationship between alpha 1-antitrypsin inactivation and tumor necrosis factor alpha concentration in the synovial fluid of patients with rheumatoid arthritis. Arthritis Rheum, 37(12), 1723-1726. Abstract.  Author URL.
KUS ML, FAIRBURN K, MORRIS CJ, BLAKE DR, WINYARD PG (1994). THE ROLE OF OXIDATIVELY MODIFIED LDL IN RHEUMATOID-ARTHRITIS. JOURNAL OF CELLULAR BIOCHEMISTRY, 269-269.  Author URL.
Blake DR, Winyard PG, Marok R (1994). The Contribution of Hypoxia-Reperfusion Injury to Inflammatory Synovitis: the Influence of Reactive Oxygen Intermediates on the Transcriptional Control of Inflammation. Ann N Y Acad Sci, 723(1), 308-317.  Author URL.
Blake DR, Winyard PG, Marok R (1994). The contribution of hypoxia-reperfusion injury to inflammatory synovitis: the influence of reactive oxygen intermediates on the transcriptional control of inflammation. Ann N Y Acad Sci, 723, 308-317.  Author URL.
Morris R, Winyard PG, Blake DR, Morris CJ (1994). Thrombin in inflammation and healing: relevance to rheumatoid arthritis. Ann Rheum Dis, 53(1), 72-79.  Author URL.
Edmonds SE, Blake DR, Morris CJ, Winyard PG (1993). An imaginative approach to synovitis--the role of hypoxic reperfusion damage in arthritis. J Rheumatol Suppl, 37, 26-31. Abstract.  Author URL.
Winrow VR, Winyard PG, Morris CJ, Blake DR (1993). Free radicals in inflammation: second messengers and mediators of tissue destruction. Br Med Bull, 49(3), 506-522. Abstract.  Author URL.
Zhang Z, Farrell AJ, Blake DR, Chidwick K, Winyard PG (1993). Inactivation of synovial fluid alpha 1-antitrypsin by exercise of the inflamed rheumatoid joint. FEBS Lett, 321(2-3), 274-278. Abstract.  Author URL.
Bashir S, Harris G, Denman MA, Blake DR, Winyard PG (1993). Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases. Ann Rheum Dis, 52(9), 659-666. Abstract.  Author URL.
Fairburn K, Stevens CR, Winyard PG, Kus M, Ward RJ, Cunningham J, Zaidi M, Blake DR (1993). Oxidative stress and its control: a pathogenetic role in inflammatory joint disease. Biochem Soc Trans, 21(2), 371-375.  Author URL.
Winyard PG, Tatzber F, Esterbauer H, Kus ML, Blake DR, Morris CJ (1993). Presence of foam cells containing oxidised low density lipoprotein in the synovial membrane from patients with rheumatoid arthritis. Ann Rheum Dis, 52(9), 677-680. Abstract.  Author URL.
Fairburn K, Grootveld M, Ward RJ, Abiuka C, Kus M, Williams RB, Winyard PG, Blake DR (1992). Alpha-tocopherol, lipids and lipoproteins in knee-joint synovial fluid and serum from patients with inflammatory joint disease. Clin Sci (Lond), 83(6), 657-664. Abstract.  Author URL.
Winyard PG, Faux SP, Smith AJ, Davies JE, Chipman JK (1992). Bleomycin-induced unscheduled DNA synthesis in non-permeabilized human and rat hepatocytes is not paralleled by 8-oxo-7,8-dihydrodeoxyguanosine formation. Biochem Pharmacol, 44(7), 1255-1260. Abstract.  Author URL.
WINYARD PG, BLAKE DR, CHIDWICK K, ZHANG Z (1992). INACTIVE ALPHA-1 ANTITRYPSIN IN RHEUMATOID SYNOVIAL-FLUID - OXIDATION, PROTEOLYSIS, OR COMPLEX-FORMATION - REPLY. ANNALS OF THE RHEUMATIC DISEASES, 51(8), 1023-1023.  Author URL.
Stanworth DR, Dawes PT, Winyard PG, Blake DR, Chidwick K, Zhang Z (1992). Inactive α<inf>1</inf> antitrypsin in rheumatoid synovial fluid: Oxidation, proteolysis, or complex formation? [4]. Annals of the Rheumatic Diseases, 51(8), 1022-1023.
Bucurenci N, Blake DR, Chidwick K, Winyard PG (1992). Inhibition of neutrophil superoxide production by human plasma alpha 1-antitrypsin. FEBS Lett, 300(1), 21-24. Abstract.  Author URL.
SIMMONDS NJ, BASHIR S, HARRIS G, LEE JCW, WINYARD PG, BLAKE DR, RAMPTON DS (1992). REACTIVE OXYGEN METABOLITES DAMAGE DNA IN INFLAMMATORY BOWEL-DISEASE. GUT, 33(2), S1-S1.  Author URL.
Fairburn K, Grootveld M, Ward RJ, Abiuka C, Kus M, Williams RB, Winyard PG, Blake DR (1992). α-Tocopherol, lipids and lipoproteins in knee-joint synovial fluid and serum from patients with inflammatory joint disease. Clinical Science, 83(6), 657-664. Abstract.
Chidwick K, Winyard PG, Zhang Z, Farrell AJ, Blake DR (1991). Inactivation of the elastase inhibitory activity of alpha 1 antitrypsin in fresh samples of synovial fluid from patients with rheumatoid arthritis. Ann Rheum Dis, 50(12), 915-916. Abstract.  Author URL.
Winyard PG, Zhang Z, Chidwick K, Blake DR, Carrell RW, Murphy G (1991). Proteolytic inactivation of human alpha 1 antitrypsin by human stromelysin. FEBS Lett, 279(1), 91-94. Abstract.  Author URL.
Merry P, Smith E, Stevens C, Winyard P, Blake DR (1991). Synovial fluid polymorphs and the oxygen paradox. Rheumatology (United Kingdom), 30
Zhang Z, Winyard PG, Chidwick K, Farrell A, Pemberton P, Carrell RW, Blake DR (1990). Increased proteolytic cleavage of alpha 1-antitrypsin (alpha 1-proteinase inhibitor) in knee-joint synovial fluid from patients with rheumatoid arthritis. Biochem Soc Trans, 18(5), 898-899.  Author URL.
Griffiths HR, Lunec J, Diplock AT, Winyard PG, Perrett D, Blake DR, Harris G, Chipman JK, Dodd NJF, Dalgarno BG, et al (1990). Protein fluorescence: its generation and measurement. Analytical Proceedings, 27(8), 222-229.
Winyard PG, Hider RC, Brailsford S, Drake AF, Lunec J, Blake DR (1989). Effects of oxidative stress on some physiochemical properties of caeruloplasmin. Biochem J, 258(2), 435-445. Abstract.  Author URL.
Winyard PG, Arundell LA, Blake DR (1989). Lipoprotein oxidation and induction of ferroxidase activity in stored human extracellular fluids. Free Radic Res Commun, 5(4-5), 227-235. Abstract.  Author URL.
MERRY P, WINYARD PG, MORRIS CJ, GROOTVELD M, BLAKE DR (1989). OXYGEN FREE-RADICALS, INFLAMMATION, AND SYNOVITIS - THE CURRENT STATUS. ANNALS OF THE RHEUMATIC DISEASES, 48(10), 864-870.  Author URL.
Pall H, Blake DR, Winyard P, Lunec J, Williams A, Good PA, Kritzinger EE, Cornish A, Hider RC (1989). Ocular toxicity of desferrioxamine--an example of copper promoted auto-oxidative damage?. Br J Ophthalmol, 73(1), 42-47. Abstract.  Author URL.
Merry P, Winyard PG, Morris CJ, Grootveld M, Blake DR (1989). Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status. Ann Rheum Dis, 48(10), 864-870.  Author URL.
Winkles J, Jones AF, Winyard P, Blake DR, Lunec J (1988). An automated method for the kinetic measurement of ferroxidase activity. Ann Clin Biochem, 25 ( Pt 3), 250-254. Abstract.  Author URL.
Winyard PG, Hider RC, Lunec J, Drake AF, Blake DR (1988). Role of oxidative modification in the lability of ceruloplasmin. Basic Life Sci, 49, 341-345.  Author URL.
Winyard PG, Blake DR, Chirico S, Gutteridge JM, Lunec J (1987). Mechanism of exacerbation of rheumatoid synovitis by total-dose iron-dextran infusion: in-vivo demonstration of iron-promoted oxidant stress. Lancet, 1(8524), 69-72. Abstract.  Author URL.
Pall HS, Williams AC, Blake DR, Winyard P, Chirico S, Brailsford S (1987). Movement disorder associated with abnormal copper metabolism and decreased blood antioxidants. J Neurol Neurosurg Psychiatry, 50(9), 1234-1235.  Author URL.
Winyard PG, Pall H, Lunec J, Blake DR (1987). Non-caeruloplasmin-bound copper ('phenanthroline copper') is not detectable in fresh serum or synovial fluid from patients with rheumatoid arthritis. Biochem J, 247(1), 245-246.  Author URL.
WINYARD PG, BRAILSFORD S, LUNEC J, BLAKE DR (1987). SECRETION OF CERULOPLASMIN BY THE RHEUMATOID SYNOVIAL-MEMBRANE AND LIVER. BRITISH JOURNAL OF RHEUMATOLOGY, 26, 21-22.  Author URL.
Pall H, Blake DR, Good PA, Winyard P, Williams AC (1986). Copper chelation and the neuro-ophthalmic toxicity of desferrioxamine. Lancet, 2(8518).  Author URL.
Pall HS, Williams AC, Blake DR, Winyard P, Lunec J (1986). Lipid peroxidation and Parkinson's disease. Lancet, 2(8511), 870-871.  Author URL.
Brailsford S, Lunec J, Winyard P, Blake DR (1985). A possible role for ferritin during inflammation. Free Radic Res Commun, 1(2), 101-109. Abstract.  Author URL.
Blake DR, Winyard P, Lunec J, Williams A, Good PA, Crewes SJ, Gutteridge JM, Rowley D, Halliwell B, Cornish A, et al (1985). Cerebral and ocular toxicity induced by desferrioxamine. Q J Med, 56(219), 345-355. Abstract.  Author URL.
Blake DR, Winyard P, Scott DG, Brailsford S, Blann A, Lunec J (1985). Endothelial cell cytotoxicity in inflammatory vascular diseases--the possible role of oxidised lipoproteins. Ann Rheum Dis, 44(3), 176-182. Abstract.  Author URL.
Gutteridge JM, Winyard PG, Blake DR, Lunec J, Brailsford S, Halliwell B (1985). The behaviour of caeruloplasmin in stored human extracellular fluids in relation to ferroxidase II activity, lipid peroxidation and phenanthroline-detectable copper. Biochem J, 230(2), 517-523. Abstract.  Author URL.
Winyard P, Lunec J, Brailsford S, Blake D (1984). Action of free radical generating systems upon the biological and immunological properties of caeruloplasmin. Int J Biochem, 16(12), 1273-1278. Abstract.  Author URL.
Falk KE, Jovall PA, Winyard P (1982). Proton NMR studies of a tetrasaccharide which is a receptor for uropathogenic E. coli bacteria. Acta Chem Scand B, 36(8), 558-560.  Author URL.

Chapters

Winyard PG (In Press). Key Stages in the Acute Inflammatory Response and Their Relevance as Therapeutic Targets Introduction to Part 1. In  (Ed) Inflammation Protocols, Humana Press, 3-6.
Trenam CW, Winyard PG, Morris CJ, Blake DR (2018). Iron-Promoted Oxidative Damage in Rheumatic Diseases. In  (Ed) Iron and Human Disease, Taylor & Francis, 395-418.
Trenam CW, Winyard PG, Morris CJ, Blake DR (2018). Iron-promoted oxidative damage in rheumatic diseases. In  (Ed) Iron and Human Disease, 395-418. Abstract.
Ryan B, Lo Faro ML, Whiteman M, Winyard PG (2016). Reactive Oxygen Species. In Parnham M (Ed) Compendium of Inflammatory Diseases, Basel: Springer.
Ryan BJ, Lo Faro ML, Whiteman M, Winyard PG (2015). Reactive Oxygen Species. In  (Ed) Encyclopedia of Inflammatory Diseases, Springer Nature, 1-6.
Jacob C, Burkholz T, Kirsch G, Slusarenko A, Winyard PG (2014). Introduction. In  (Ed) , 1-11. Abstract.
Jacob C, Burkholz T, Kirsch G, Slusarenko A, Winyard PG (2014). Introduction. In  (Ed) Recent Advances in Redox Active Plant and Microbial Products, Springer Nature, 1-11.
Jacob C, Burkholz T, Kirsch G, Slusarenko A, Winyard PG (2014). Some personal conclusions. In  (Ed) Recent Advances in Redox Active Plant and Microbial Products: from Basic Chemistry to Widespread Applications in Medicine and Agriculture, 471-475. Abstract.
Szabó-Taylor KE, Nagy G, Eggleton P, Winyard PG (2013). Oxidative Stress in Rheumatoid Arthritis. In Alcaraz MJ (Ed) Studies on Arthritis and Joint Disorders, Oxidative Stress in Applied Basic Research and Clinical Practice, Springer Science+Business Media, 145-167. Abstract.
Prichard A, Kinna R (2012). Introduction. In Prichard A, Kinna R, Pinta S, Berry D (Eds.) Libertarian Socialism: Politics in Black and Red, Houndmills: Palgrave, 1-17.
Kendall A, Smerdon G, Harries LW, Winyard PG, Eggleton P, Whatmore J (2011). Hyperbaric Oxygen Therapy and chronic wound healing. In Middleton JE (Ed) Wound Healing: Process, Phases and Promoting, Nova Publishers, 145-177.
Jacob C, Winyard PG (2009). Introduction. In  (Ed) Redox Signaling and Regulation in Biology and Medicine, Wiley, 1-11.
Jacob C, Winyard PG (2009). Introduction. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: Wiley-VCH, 1-13.
Pye A, Dogra Y, Tyrrell J, Winyard PG, Curnow A (2009). Photodynamic therapy with aminolevulinic acid and iron chelators: a clinical example of redox signaling. In Jacob C, Winyard PG, Wiley-VCH (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: , 351-372.
Jacob C, Winyard PG (2009). Preface. In  (Ed) .
Davies C, Blake D, Winyard P (2009). Radicals and Inflammation. In  (Ed) Environmental Stressors in Health and Disease, CRC Press.
Szabo K, Gutowski NJ, Holley JE, Littlechild JA, Winyard P (2009). Redox Control in Human Disease with a Special Emphasis on the Peroxiredoxin-Based Antioxidant System. In Jacob C, Winyard PG (Eds.) Redox signaling and regulation in biology and medicine, Vch Verlagsgesellschaft Mbh, 409-431. Abstract.
Szabo KE, Gutowski NJ, Holley JE, Littlechild JA, Winyard PG (2009). Redox control in human disease with a special emphasis on the peroxiredoxin-based antioxidant system. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: Wiley-VCH, 447-472.
Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxierdoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim, Germany: Wiley-VCH.
Szabo KE, Line K, Eggleton P, Littlechild JA, Winyard PG (2009). Structure and function of the human peroxiredoxin-based antioxidant system: the interplay between peroxiredoxins, thioredoxins, thioredoxin reductases, sulfiredoxins and sestrins. In Jacob C, Winyard PG (Eds.) Redox Signaling and Regulation in Biology and Medicine, Weinheim: Wiley-VCH-Verlag, 151-192.
Whiteman M, Dogra Y, Winyard PG, Armstrong JS (2007). Detection and measurement of reactive oxygen intermediates in mitochondria and cells. In Hancock J (Ed) Redox Signal Transduction, Methods in Molecular Biology, New Jersey, USA: Humana Press.
Taylor EL, Winyard PG (2007). S-nitrosothiols and disease. In Bahir M, Matata (Eds.) Oxidative Stress: Clinical and Biomedical Implications, Nova Press.
Winyard PG (2003). Key Stages in the acute inflammatory response and their relevance as therapeutic targets. In Winyard PG, Willoughby D (Eds.) Inflammation Protocols, Totowa, USA: Hymana Press, 3-6.
Davies CA, Blake DR, Winyard PG (2001). Radicals and inflammation: mediators and modulators. In Fuchs J, Packer L (Eds.) Enviromental Stressors:Effects on Lung, Skin, Eye and Immune System Function, New York: Marcel Dekker, 17-52.
Blake DR, Bodamyali T, Stevens CR, Winyard PG (2000). Free radicals and pathology: current concepts. In  (Ed) Free Radicals and Inflammation, Birkhäuser Basel, 17-19.
Gilston V, Blake DR, Winyard PG (2000). Inflammatory mediators, free radicals and gene transcription. In  (Ed) Free Radicals and Inflammation, Birkhäuser Basel, 83-98.
Blake DR, Bodamyali T, Stevens CR, Winyard PG (2000). Introduction. In  (Ed) Free Radicals and Inflammation, Springer Nature, 1-9.
Bodamyali T, Stevens CR, Blake DR, Winyard PG (2000). Reactive oxygen/nitrogen species and acute inflammation: a physiological process. In  (Ed) Free Radicals and Inflammation, Birkhäuser Basel, 11-16.
Winyard PG, Zhang Z, Blake DR (1998). Free radicals in rheumatoid arthritis: redox regulation of gene transcription and proteolytic tissue destruction. In Thomas CE, Kalyanaraman B (Eds.) Oxygen radicals and the disease process, CRC.
Winyard PG, Zhang Z, Blake DR (1997). Free radicals in rheumatoid arthritis: redox regulation of gene transcription and proteolytic tissue desctruction. In Thomas CE, Kalyanaraman B (Eds.) Oxygen Radicals and the Disease Process, Amsterdam: Harwood Academic Publishers.
(1997). The Rheumatoid Joint: Redox-Paradox?. In  (Ed) Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases, CRC Press, 533-562.
Zhang Z, Frears E, Blake DR, Winyard PG (1996). Inactivation of alpha-1-proteinase inhibitor by the simultaneous generation of nitric oxide and superoxide. In Packer L, Traber MG, Xin W (Eds.) , New York: Taylor & Francis, 359-366.  Author URL.
Kus ML, Fairburn K, Blake D, Winyard PG (1995). 7 a Vascular Basis for Free Radical Involvement in Inflammatory Joint Disease. In  (Ed) Immunopharmacology of Free Radical Species, Elsevier, 97-112.
Kus ML, Fairburn K, Blake D, Winyard PG (1995). A Vascular Basis for Free Radical Involvement in Inflammatory Joint Disease. In  (Ed) Immunopharmacology of Free Radical Species, Elsevier, 97-112.
Blake D, Winyard PG (1995). Preface. In  (Ed) Immunopharmacology of Free Radical Species, Elsevier.
Winyard PG, Morris CJ, Winrow VR, Zaidi M, Blake DR (1994). Chapter 15 Free radical pathways in the inflammatory response. In  (Ed) Free Radical Damage and its Control, Elsevier, 361-383.
Winyard PG, Perrett D, Harris G, Blake DR (1992). The role of toxic oxygen species in inflammation with special reference to DNA damage. In  (Ed) Biochemistry of Inflammation, Springer Netherlands, 109-129.
Winyard PG, Hider RC, Lunec J, Drake AF, Blake DR (1988). Role of Oxidative Modification in the Lability of Ceruloplasmin. In  (Ed) Oxygen Radicals in Biology and Medicine, Springer Nature, 341-345.
Blake DR, Lunec J, Winyard PG, Brailsford S (1986). Iron, free radicals and chronic inflammation. In Moll JMH, Sturrock RD (Eds.) Recent advances in rheumatology.
Blake DR, Lunec J, Brailsford S, Winyard PG, Bacon PA (1985). Oxygen free radicals and inflammatory joint disease. In Decker J, Scott T (Eds.) Perspectives in rheumatology 1984.

Conferences

Nice R, Goodhand JR, Kennedy N, Ahmad T, Winyard P, McDonald TJ (2022). Pre-treatment antibodies to infliximab and adalimumab are common but are not associated with anti-TNF treatment failure.  Author URL.
Riddell A, Kirkwood J, Smallwood M, Winyard P, Knight B, Steer K, Puddicombe L, Romanczuk L, Shore A, Gilchrist M, et al (2020). CAN THE URINARY NITRATE TO CREATININE RATIO BE USED AS a MARKER FOR KIDNEY TRANSPLANT REJECTION?.  Author URL.
Stewart K, Winyard P (2020). Watercress and the gut.  Author URL.
Ferguson D, Perry A, Wood ME, Winyard PG, Whiteman M (2014). Potentiation of Methyl Aminolevulinate (MAL)-Induced Photodynamic Therapy (PDT) Killing of Skin Cancer Cells by Mitochondria-Targeted Hydrogen Sulfide (H<sub>2</sub>S) Donors.  Author URL.
Fox B, Holland T, Wood ME, Winyard PG, Whiteman M (2013). Comparing the differential effects of novel, slow-release H<sub>2</sub>S donors on inflammatory mediators and cell proliferation in human joint and immune cells.  Author URL.
Lo Faro ML, Whatmore J, More J, Whiteman M, Winyard PG (2013). Is hydrogen sulfide involved in mediating functional effects of dietary nitrate ingestion in humans?.  Author URL.
Whiteman M, Perry A, Le Trionnaire S, Whatmore JL, Ahmed T, Fox B, Kerr P, Haigh R, Winyard PG, Wood ME, et al (2013). Modulation of inflammatory and vascular signalling by novel slow release and mitochondria-targeted H<sub>2</sub>S donors.  Author URL.
Ferguson D, Smerdon GR, Eggleton P, Curnow A, Winyard PG (2012). Altering oxygen concentrations to enhance the efficacy of PpIX-based photodynamic cell killing.
Fox B, Perry A, Winyard P, Wood ME, Whiteman M (2012). Characterising the effect of novel slow-release H<sub>2</sub>S donors on pro-inflammatory enzyme activity in human cartilage cells.  Author URL.
Fox B, Holland T, Perry A, Winyard PG, Wood ME, Whiteman M (2012). Defining the Effect of Novel Slow-Release H<sub>2</sub>S Donors on Pro-Inflammatory Mediators and Enzymes in Human Joint Cells.  Author URL.
Winyard PG, Nissim A, Whiteman M, Eggleton P (2012). Measurement of serum autoantibodies against oxidatively modified autoantigens in human autoimmune diseases.
Le Trionnaire S, Perry A, Whatmore JL, Winyard PG, Wood ME, Whiteman M (2012). Mitochondria-Targeted Slow Release Hydrogen Donors: a Novel Link to an Old 'tail'?.  Author URL.
Lo Faro ML, Whatmore J, More J, Wood ME, Whiteman M, Winyard PG (2012). Mutual regulation of <SUP>•</SUP>NO/H<sub>2</sub>S bioavailability and cell signalling in the cardiovascular system.  Author URL.
Fox B, Li L, Keeble J, Winyard P, Wood M, Moore P, Whiteman M (2012). The complex effects of a slow-releasing hydrogen sulifde donor (GYY4137) in a model of inflammatory arthritis and in primary human cartilage cells.  Author URL.
Smallwood MJ, Jewell SA, Petrov PG, Winlove CP, Eggleton P, Winyard PG (2012). The role of phosphatidylserine externalisation and oxidation in C1q-dependent apoptotic cell clearance.
Gilchrist M, Winyard PG, Shore AC, Benjamin N (2011). Dietary nitrate fails to lower blood pressure in patients with type 2 diabetes.  Author URL.
Bailey SJ, Fulford J, Vanhatalo A, Winyard P, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM (2011). Dietary nitrate supplementation enhances muscle efficiency during knee-extensor exercise in humans.
Eggleton P, Tarr JM, Winyard PG, Haigh R, Viner N (2011). FREQUENCY OF TH17 CD20+CELLS IN THE BLOOD OF RHEUMATOID ARTHRITIS PATIENTS IS HIGHER COMPARED TO HEALTHY CONTROL SUBJECTS.  Author URL.
Whiteman M (2011). HYDROGEN SULFIDE AND NITRIC OXIDE INTERACTIONS IN INFLAMMATION.  Author URL.
Eggleton P, Ryan B, Brown S, Johnson S, Viner N, Nissim A, Isenberg D, Haigh R, Winyard P (2011). POST-TRANSLATIONAL MODIFICATIONS OF C1Q LEAD TO ANTIGENICITY AND BREAKDOWN OF IMMUNE TOLERANCE IN SYSTEMIC LUPUS ERYTHEMATOSUS.  Author URL.
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Al-Kashi A, Winyard P, Chernajovsky Y, Nissim A (2011). Targeting therapeutics to arthritic joints.  Author URL.
Gutowski N, Winyard PG, Szabo-Taylor K, Holley JE (2010). ALTERED PEROXIREDOXIN ANTIOXIDANT ENZYME EXPRESSION IN ACTIVATED AND QUIESCENT HUMAN ASTROCYTES.  Author URL.
Lo Faro ML, Burkholz T, Whiteman M, Winyard PG (2010). Hydrogen Sulfide and Nitric Oxide Cross-talk: Evidence for Hydrogen Sulfide Mediated Nitric Oxide Production from Nitrite.  Author URL.
Gutowski NJ, Holley JE, Szabo-Taylor K, Winyard PG (2010). Modification of peroxiredoxin antioxidant enzyme expression in activated and quiescent human astrocytes in vitro.  Author URL.
Ryan B, Eggleton P, Brown S, Viner N, Nissim A, Isenberg D, Haigh R, Winyard PG (2010). Oxidative and Nitrative Modification of C1q Affects its Structure, Function and Antigenicity in Systemic Lupus Erythematosus.  Author URL.
Szabo-Taylor KE, Lo Faro ML, Eggleton P, Turner CAL, Tarr JM, Haigh RC, Littlechild JA, Whiteman M, Winyard PG (2010). Peroxiredoxin 2 in Human Inflammatory Joint Disease.  Author URL.
Taylor E, Armstrong K, Hattersley A, Winyard P (2009). Advanced oxidation protein products are elevated in hypertensive individuals.  Author URL.
Eggleton P, Haigh R, Viner N, Donnelly S, Harries LW, Alberigo G, Winyard PG (2009). DIFFERENCES IN APOPTOSIS GENE EXPRESSION IN LYMPHOCYTES FROM SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) AND RHEUMATOID ARTHRITIS (RA) PATIENTS.  Author URL.
Tarr JM, Szabo K, Haigh RC, Viner NJ, Eggleton P, Winyard PG (2009). DOES TREATMENT WITH RITUXIMAB INDUCE APOPTOSIS IN T LYMPHOCYTES?.  Author URL.
Whiteman M, Tarr J, Moore PK, Haigh R, Winyard PG (2009). ELEVATED SYNOVIAL FLUID LEVELS OF HYDROGEN SULFIDE (H2S) IN RHEUMATOID ARTHRITIS: CORRELATION WITH DISEASE ACTIVITY AND OTHER CLINICAL INFLAMMATORY INDICES.  Author URL.
Turner CA, Szabo KE, Haigh R, Tarr J, Littlechild JA, Eggleton P, Winyard PG (2009). EXPRESSION OF THE PEROXIREDOXIN-BASED ANTIOXIDANT SYSTEM IN PERIPHERAL BLOOD LYMPHOCYTES IN RHEUMATOID ARTHRITIS.  Author URL.
Whiteman M, Haigh R, Winyard P (2009). Hydrogen Sulfide in Plasma and Knee-Joint Synovial Fluid from Rheumatoid Arthritis Patients: Relation to Clinical and Laboratory Measures of Inflammation.  Author URL.
Ryan B, Winyard PG, Viner N, Haigh R, Haas M, Nissim A, Isenberg D, Eggleton P (2009). OXIDATIVE MODIFICATIONS TO C1Q INCREASE THE SENSITIVITY OF AN ANTI-C1Q ELISA IN THE DIAGNOSIS OF SYSTEMIC LUPUS ERYTHEMATOSUS.  Author URL.
Gutowski NJ, Watson EL, Holley JE, Winyard PG, Littlechild JA (2009). Peroxiredoxin II: an antioxidant with therapeutic potential in multiple sclerosis?.  Author URL.
Curnow A, Dogra P, Winyard P, Campbell S (2009). Using iron chelating agents to enhance dermatological PDT. Photodynamic Therapy - Back to the Future. Abstract.
Moody J, Winyard PG (2008). Bioanalysis in Oxidative Stress. Biochemical Society Transactions. 2nd - 3rd Apr 2008.
Szabo K, Tarr J, Eggleton P, Line K, Ryan B, Aksu K, Akcay Y, Haigh R, Littlechild J, Winyard P, et al (2008). Extracellular peroxiredoxin II in rheumatoid arthritis and other autoimmune conditions.  Author URL.
Tarr JM, Haas M, Haigh R, Eggleton P, Winyard PG (2008). Measurement of calreticulin in plasma and synovial fluid from rheumatoid arthritis patients.  Author URL.
Ryan B, Szestakowska D, Viner N, Haigh R, Haas M, Nissim A, Isenberg D, Winyard P, Eggleton P (2007). Autoantibodies target oxidatively modified proteins of the C1q/calreticulin/CD91 apoptotic pathway in systemic lupus erythematosus.  Author URL.
Dogra Y, Curnow A, Winyard P (2007). Mechanisms of cell death induced by dermatological protoporphyrin IX-induced photodynamic therapy.  Author URL.
Winyard PG, Eggleton P, Jones HW, Thomson AER, O'Connor TWE, Gruska AM, Chikanza IC, Williams MA, Harries L (2006). Apoptotic activity in patients with rheumatoid arthritis and systemic lupus erythematosus.  Author URL.
Eggleton P, Szestakowska D, Winyard PG, Viner N, Nissim A (2006). Generation of neo-antigenic epitopes recognised by autoimmune sera after the post-translational modification of human C1q by free radicals.  Author URL.
Winyard PG, Nissim A, Davies C, Rocks S, Benjamin N (2006). Nitrosative stress in the inflamed joints of rheumatoid arthritis patients.  Author URL.
Ahmed N, Ahmed U, Thornalley PJ, Watts R, Tarr J, Haigh R, Winyard P (2006). Profound increase in proteolytic products of glycated and oxidised proteins in synovial fluid and plasma in osteoarthritis and rheumatoid arthritis, corrected by TNF-α antibody therapy in rheumatoid arthritis.  Author URL.
Szestakowska D, Young P, Morse R, Viner N, Isenberg D, Nissim A, Eggleton P, Winyard P (2006). Role of oxidative protein modifications in the generation of neoantigens recognised by lupus patient sera.  Author URL.
Shaw FL, Eggleton P, Moody AJ, Smerdon GR, Bryson PJ, Winyard P (2006). The effect of hyperbaric oxygen on platelet S-nitrosothiol release and aggregation.  Author URL.
Tarr J, Eggleton P, Haigh R, Winyard P (2006). The effect of nitric oxide on the apoptosis of Jurkat T cells.  Author URL.
Nissim A, Winyard P, Davis C, Cohen G, Chernajovsky Y (2005). Development of human antibody fragments against collagen type II autoantigens in rheumatoid arthritis, using phage display libraries.  Author URL.
Holley J, Newcombe J, Winyard P, Gutowski N (2005). Localisation of peroxiredoxin v in multiple sclerosis lesions.  Author URL.
Glantzounis GK, Hafez T, Yang W, Rocks SA, Salacinski H, Sheth H, Parks HG, Fuller B, Winyard PG, Seifalian AM, et al (2005). N-Acetylcysteine reduces liver warm ischaemia-reperfusion injury via modulation of nitric oxide metabolism.  Author URL.
O'Shaughnessy M, Vetsika EK, Inglis J, Carleson J, Haigh R, Kidd B, Winyard P (2005). Role of nitric oxide in the pro-inflammatory effects of substance P.  Author URL.
Rocks S, Davies C, Hicks S, Webb A, Klocke R, Timmins G, Johnston A, Jawad A, Blake D, Benjamin N, et al (2005). Validation and clinical applications of a new EPR assay for plasma S-nitrosothiols.  Author URL.
Glantzounis GK, Hafez T, Wang WX, Rocks S, Salacinski H, Sheth H, Parkes H, Fuller B, Winyard P, Seifalian A, et al (2004). Continuous infusion of N-acetylcysteine improves cellular energy production and decreases plasma S-nitrosothiols following liver ischemia-reperfusion injury.  Author URL.
Nissim A, Winyard P, Fatah R, Perrett D, Chernajovsky Y, Panayi G, Corrigall V (2004). Generation of neo-antigenic epitopes after the post-translational modification of type II collagen by factors present within the inflamed joint.  Author URL.
Glantzounis GK, Rocks S, Sheth H, Salacinski HJ, Davidson BR, Winyard PG, Seifalian AM (2004). Increased formation of nitrosothiols following warm liver ischaemia reperfusion injury.  Author URL.
Gutowski NJ, Holley JE, Newcombe J, Winyard PG (2004). Peroxiredoxin V changes in multiple sclerosis.  Author URL.
Glantzounis GK, Rocks SA, Sheth H, Salacinski HJ, Davidson BR, Winyard PG, Seifalian AM (2003). Measurement of nitrosothiols by electron paramagnetic resonance spectroscopy in an experimental lobar liver ischemia-reperfusion model.  Author URL.
Golledge P, Knight CJ, Davies CA, Perrett D, Winyard PG (2002). Balloon injury impairs intravascular production of nitric oxide during percutaneous transluminal coronary angioplasty in man.  Author URL.
Guo R, Neilson B, Davies C, D'Cruz D, Winyard P (2002). Detection of a novel oxidising species in the plasma of SLE patients using the spin trap DBNBS.  Author URL.
Guo R, D'Cruz D, Davies C, Rocks S, Golledge P, Alba P, Ferro L, Winyard P (2002). Detection of a novel urinary oxidant as a diagnostic indicator of active nephritis in patients with connective tissue disease.  Author URL.
Golledge P, Rocks S, Davies CA, Knight CJ, Winyard PG (2002). Detection of free radical production during coronary angioplasty using EPR and PBN spin trapping.  Author URL.
Timmins GS, Harris M, Burchiel S, Winyard P, Engen J, Mobarak C (2002). The myoglobin radical produced upon reaction with hydrogen peroxide is at TYR-103: Determination by combined use of EPR, electrophoretic purification, and mass spectrometry.  Author URL.
Gilston V, Jones HW, Soo CC, Coumbe A, Blades S, Kaltschmidt C, Baeuerle PA, Morris CJ, Blake DR, Winyard PG, et al (1997). NF-κB activation in human knee-joint synovial tissue during the early stage of joint inflammation.
ASMAR G, CHIDWICK K, SMITH EC, ZHANG Z, ARCHER JR, BLAKE DR, WINYARD PG (1992). DETERMINATION OF CLEAVED ALPHA-1-ANTITRYPSIN IN ARTHRITIC SYNOVIAL-FLUIDS AND SERA BY AN ENZYME-LINKED-IMMUNOSORBENT-ASSAY (ELISA).  Author URL.
WINYARD PG, BLAKE DR, PALL H, LUNEC J (1987). NON-CERULOPLASMIN-BOUND COPPER (PHENANTHROLINE COPPER) IS NOT DETECTABLE IN FRESH SERUM OR SYNOVIAL-FLUID FROM PATIENTS WITH RHEUMATOID-ARTHRITIS (RA).  Author URL.
WINYARD PG, BLAKE DR, CHIRICO S, WINKLES J, ROBINSON RH, GUTTERIDGE J, LUNEC J (1986). BIOCHEMICAL-CHANGES ASSOCIATED WITH IRON DEXTRAN MEDIATED SYNOVITIS IN RHEUMATOID-ARTHRITIS.  Author URL.
WINYARD PG, BLAKE DR, GUTTERIDGE JMC, BRAILSFORD S, LUNEC J (1986). COPPER, LIPID-PEROXIDATION AND CYTOTOXIC FACTORS.  Author URL.
BRAILSFORD S, BLAKE D, LUNEC J, GILBEY S, WINYARD P (1985). SYNOVIAL MACROPHAGE DYSFUNCTION IN RHEUMATOID-ARTHRITIS.  Author URL.
BLAKE DR, BRAILSFORD S, WINYARD P, LUNEC J (1984). A ROLE FOR EXTRACELLULAR FERRITIN IN INFLAMMATION.  Author URL.
WINYARD P, BLAKE D, RIDLEY J, BRAILSFORD S, BLANN A, LUNEC J (1984). CERULOPLASMIN INFLAMMATORY JOINT DISEASE.  Author URL.
SCOTT DGI, BLAKE DR, BLANN A, SALMON M, BRAILSFORD S, WINYARD P, BACON PA (1984). THE ROLE OF LYMPHOCYTES AND SERUM FACTORS IN VASCULITIC DISEASES.  Author URL.
BLAKE DR, SCOTT DGI, WINYARD P, BACON PA, LUNEC J (1983). CERULOPLASMIN, FERROXIDASE ACTIVITY AND NECROTIZING VASCULITIS.  Author URL.
BLAKE DR, WINYARD P, SCOTT DGI, LUNEC J, BACON PA (1983). OXIDIZED LIPOPROTEINS AND NECROTIZING ARTERITIS.  Author URL.
FALK KE, JOVALL PA, WINYARD P (1982). MICELLAR SYSTEMS FOR HIGH-RESOLUTION PROTON MAGNETIC-RESONANCE SPECTROSCOPY OF GLYCOSPHINGOLIPIDS.  Author URL.

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