University of Exeter Medical School

Dr Pamela Bowman

Dr Pamela Bowman

Academic Clinical Lecturer in Clinical Genetics

 P.Bowman@exeter.ac.uk

 01392 408325

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

I am an Academic Clinical Lecturer in Clinical Genetics with an interest in neonatal diabetes and precision treatment of monogenic neurodevelopmental disorders.  I am based in Professor Hattersley's clinical and monogenic diabetes research teams for academic work and in the Clinical Gentics department at the RDUH NHS Trust for clinical work.  

Qualifications

University Education

King’s College Cambridge University (2001-2004): MA medical sciences class 2:1 (cellular and genetic pathology, immunology and physiology). Dissertation on prognostic markers and therapeutic strategies in prostate cancer.

Imperial College London (2004-2007): MBBS with Distinction in clinical science and clinical practice.

University of Exeter (2017 – 2019): MSc in Genomic Medicine with Distinction

University of Exeter (2015 – 2020): PhD Fellowship ‘Assessing the glycaemic and CNS response to sulphonylureas in patients with KCNJ11 mutations’, Diabetes UK Sir George Alberti Clinical Research Training Fellowship.  Pass with no corrections.

Prizes/Awards/Distinctions

Postgraduate

Diabetes UK Young Investigator Award (£1000).  8th March 2019.  Awarded for best oral presentation by investigator under 35 years of age at Diabetes UK National APC, Liverpool 2019. 

Devon & Exeter Medical Society Postgraduate Prize for junior doctors (£500) June 2017.  Awarded for best presentation of research from doctors up to Registrar level in the South West Peninsula – ‘Precision Medicine at it’s best: The impact of KCNJ11 mutations and response to treatment with sulphonylureas.’

Academy of Medical Sciences South West Regional Poster and Presentation Prize, clinical category (£250) May 2017. ‘Sulphonylureas are a highly effective long-term treatment for KCNJ11 neonatal diabetes: The first 10-year follow-up study of a large international cohort.’

Gillian Page Research Prize 2015, Royal College of Psychiatrists Child and Adolescent Faculty (£500). Essay – ‘Characterising the psychiatric and neuropsychological phenotype in children with KCNJ11 neonatal diabetes.’

Core Psychiatric Trainee of the Year 2013, Royal College of Psychiatrists (£300, book vouchers).  Ceremony held at Royal Society of Medicine, London, on 14th November 2013.

Outstanding F2 trainee 2008/2009 (£50).  Awarded by Royal Devon and Exeter NHS Foundation Trust based on portfolio and supervisors’ recommendations.

Devon & Exeter Medical Society Postgraduate Prize for junior doctors (£1000) March 2009.  Awarded for best presentation of research from doctors up to Registrar level in the South West Peninsula – ‘Developing a novel simple test of insulin secretion.


Undergraduate

J&V Shaw Memorial Prize 2002 (£50).  Awarded for best coursework in year group at Cambridge University in Preparing for Patients module.

Rowe Prize King’s College Cambridge 2004.  Awarded by Council of King’s College to persons showing an original, creative and enthusiastic approach to their subject.

Dr Cockburn Scholarship 2004-2007 (£300/year).  Awarded by Imperial College London for outstanding performance at interview.

Frederick Bird Prize 2006.  Awarded by Imperial College London for performance in Obstetrics and Gynaecology final examination.

Merits: MBBS Part 3 written examinations in General Medicine and General Surgery (2003), MBBS Part 5 written examinations in Paediatrics and Psychiatry (2006)

Distinctions: MBBS Part 5 written examinations in Pathology (2006), MBBS Part 6 written examinations in clinical practice and clinical science (2007).

Postgraduate Examinations
MRCPCH Part 1a 12/05/09, 1b 07/09/10, Part 2 written 12/04/11, Part 2 clinical 21/06/11
MRCPsych Paper 1 24/7/12, Paper 2 09/10/12, Paper 3 16/04/13, CASC 20/01/2015

Career

Current
Academic Clinical Lecturer in Clinical Genetics (August 2021-current)

Academic
Postdoctoral clinical research fellow, University of Exeter (June 2020 – August 2021)
Clinical research fellow (OOPR), University of Exeter (September 2014 – September 2020)

Clinical
Specialty Training
Core trainee in Psychiatry (CT3), Devon Partnership NHS Trust (September 2020 – May 2021)
NIHR Academic Clinical Fellow in Psychiatry (CT2), Devon Partnership NHS Trust (September 2013 – August 2014)
Core trainee in Psychiatry, Devon Partnership NHS Trust (CT1) (August 2011 – August 2013)
NIHR Academic Clinical Fellow / ST1 in Paediatrics, RD&E NHS Foundation Trust (May 2010 – July 2011)

Foundation Training
FY2 Academic Medicine RD&E NHS FT (August 2008 – July 2009) Diabetes / endocrinology, acute medicine, research
FY1 South Devon Healthcare NHS Trust (August 2007 – August 2008) Vascular / general surgery, endocrinology / general medicine, paediatrics

Research group links

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Research

Research interests

Neonatal diabetes, monogenic diabetes, neurodevelopmental disorders, precision medicine 

Research projects

Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome.  Clinicaltrials.gov identifier NCT05751525.

Research grants

  • 2017 Humane Society
    'Roadmaps to human biology-based disease research' review article grant
  • 2016 Diabetes UK
    Diabetes UK Sir George Alberti Clinical Research Training Fellowship

Links


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Publications

Journal articles

Bowman P, Patel KA, McDonald TJ, Holst JJ, Hartmann B, Leveridge M, Shields BM, Hammersley S, Spaull SR, Knight BA, et al (2023). Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. J Diabetes Investig, 14(12), 1378-1382. Abstract.  Author URL.
Bowman P, Mathews F, Barbetti F, Shepherd MH, Sanchez J, Piccini B, Beltrand J, Letourneau-Freiberg LR, Polak M, Greeley SAW, et al (2021). Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients with Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes. Diabetes Care, 44(1), 35-42. Abstract.  Author URL.
Barash G, Bassan H, Ayelet L, Benyamini L, Heyman E, Bowman P, Barash G (2021). Novel Perspectives of Super-High Dose Glybenclamide in an Infant with DEND Syndrome. Journal of the Endocrine Society, 5(Supplement_1), a453-a453.
Barash G, Bassan H, Livne A, Benyamini L, Heyman E, Bowman P, Rachmiel M (2021). Novel perspectives of super-high dose sulfonylurea and high-dose oral prednisolone in an infant with DEND syndrome due to V64M heterozygote KCNJ11 mutation. Acta Diabetol, 58(12), 1665-1672. Abstract.  Author URL.
Novak A, Bowman P, Kraljevic I, Tripolski M, Houghton JAL, De Franco E, Shepherd MH, Skrabic V, Patel KA (2020). Transient Neonatal Diabetes: an Etiologic Clue for the Adult Diabetologist. Can J Diabetes, 44(2), 128-130.  Author URL.
De Franco E, Saint‐Martin C, Brusgaard K, Knight Johnson AE, Aguilar‐Bryan L, Bowman P, Arnoux J, Larsen AR, Sanyoura M, Greeley SAW, et al (2020). Update of variants identified in the pancreatic β‐cell K. <sub>ATP</sub>. channel genes. <i>KCNJ11</i>. and. <i>ABCC8</i>. in individuals with congenital hyperinsulinism and diabetes. Human Mutation, 41(5), 884-905.
Bowman P, Day J, Torrens L, Shepherd MH, Knight BA, Ford TJ, Flanagan SE, Chakera A, Hattersley AT, Zeman A, et al (2019). Cognitive, Neurological, and Behavioral Features in Adults with KCNJ11 Neonatal Diabetes. Diabetes Care, 42(2), 215-224. Abstract.  Author URL.
Bowman P, McDonald TJ, Knight BA, Flanagan SE, Leveridge M, Spaull SR, Shields BM, Hammersley S, Shepherd MH, Andrews RC, et al (2019). Patterns of postmeal insulin secretion in individuals with sulfonylurea-treated KCNJ11 neonatal diabetes show predominance of non-K ATP -channel pathways. BMJ Open Diabetes Research and Care, 7(1). Abstract.
Bowman P, Sulen Å, Barbetti F, Beltrand J, Svalastoga P, Codner E, Tessmann EH, Juliusson PB, Skrivarhaug T, Pearson ER, et al (2018). Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study. Lancet Diabetes Endocrinol, 6(8), 637-646. Abstract.  Author URL.
Bowman P, Flanagan SE, Hattersley AT (2018). Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity. JOURNAL OF DIABETES RESEARCH, 2018  Author URL.
Bowman P, Hattersley AT, Knight BA, Broadbridge E, Pettit L, Reville M, Flanagan SE, Shepherd MH, Ford TJ, Tonks J, et al (2017). Neuropsychological impairments in children with KCNJ11 neonatal diabetes. Diabet Med, 34(8), 1171-1173.  Author URL.
Clissold RL, Shaw-Smith C, Turnpenny P, Bunce B, Bockenhauer D, Kerecuk L, Waller S, Bowman P, Ford T, Ellard S, et al (2016). Chromosome 17q12 microdeletions but not intragenic HNF1B mutations link developmental kidney disease and psychiatric disorder. Kidney Int, 90(1), 203-211. Abstract.  Author URL.
Bowman P, Broadbridge E, Knight BA, Pettit L, Flanagan SE, Reville M, Tonks J, Shepherd MH, Ford TJ, Hattersley AT, et al (2016). Psychiatric morbidity in children with KCNJ11 neonatal diabetes. Diabet Med, 33(10), 1387-1391. Abstract.  Author URL.
Bowman P, Broadbridge E, Knight BA, Pettit L, Flanagan SE, Reville M, Tonks J, Shepherd MH, Ford TJ, Hattersley AT, et al (2016). Specific psychiatric disorders can be identified using systematic assessment in patients with <i>KCNJ11</i> neonatal diabetes. DIABETIC MEDICINE, 33, 172-173.  Author URL.
Bowman P, Knight BA, Petit L, Broadbridge E, Reville MC, Ford TJ, Tonks J, Hattersley AT (2015). Characterising the neuropsychological and psychiatric impact of potassium channel mutations on patients and their families: implications for clinical practice. DIABETIC MEDICINE, 32, 185-185.  Author URL.
Bowman P, Osborne NJ, Sturley R, Vaidya B (2012). Carbimazole embryopathy: implications for the choice of antithyroid drugs in pregnancy. QJM, 105(2), 189-193. Abstract.  Author URL.
Bowman P, Flanagan SE, Edghill EL, Damhuis A, Shepherd MH, Paisey R, Hattersley AT, Ellard S (2012). Heterozygous ABCC8 mutations are a cause of MODY. Diabetologia, 55(1), 123-127. Abstract.  Author URL.
Bowman P, Quinn M (2012). Question 1: Should steroids be used to treat abdominal pain caused by Henoch-Schonlein purpura?. Arch Dis Child, 97(11), 999-1000.  Author URL.
Thomas NJ, Shields BM, Besser REJ, Jones AG, Rawlingson A, Goodchild E, Leighton C, Bowman P, Shepherd M, Knight BA, et al (2012). The impact of gender on urine C-peptide creatinine ratio interpretation. Ann Clin Biochem, 49(Pt 4), 363-368. Abstract.  Author URL.
Bowman P, McDonald TJ, Shields BM, Knight BA, Hattersley AT (2012). Validation of a single-sample urinary C-peptide creatinine ratio as a reproducible alternative to serum C-peptide in patients with Type 2 diabetes. Diabet Med, 29(1), 90-93. Abstract.  Author URL.
Bowman P, Vaidya B (2011). Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy. J Thyroid Res, 2011 Abstract.  Author URL.
Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman P, Oram RA, Knight BA, Hattersley AT (2011). Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. Diabet Med, 28(9), 1034-1038. Abstract.  Author URL.
McDonald TJ, Knight BA, Shields BM, Bowman P, Salzmann MB, Hattersley AT (2009). Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide. Clin Chem, 55(11), 2035-2039. Abstract.  Author URL.

Conferences

Bowman P, Patel KA, McDonald TJ, Knight BA, Leveridge M, Flanagan SE, Hammersley S, Shepherd MH, Andrews RC, Hattersley AT, et al (2019). Physiological assessment of individuals with sulphonylurea-treated KCNJ11 permanent neonatal diabetes following carbohydrate and protein meals shows markedly reduced KATP mediated insulin secretion but relatively intact non-KATP pathways.  Author URL.
Bowman P, Shepherd MH, McDonald TJ, Andrews RC, Spaull SR, Statton S, Hammersley S, Leveridge M, Shields BM, Flanagan SE, et al (2018). Excess insulin secretion with a high protein meal in sulphonylurea treated KCNJ11 neonatal diabetes patients shows the limitations of amplifying insulin secretion pathways.  Author URL.
Bowman P, Sulen A, Barbetti F, Beltrand J, Polak M, Iafusco D, Svalastoga P, Skrivarhaug T, Klimes I, Codner E, et al (2017). SULPHONYLUREAS ARE a HIGHLY EFFECTIVE AND SAFE LONG-TERM TREATMENT FOR NEONATAL DIABETES DUE TO KCNJ11 MUTATIONS: THE FIRST 10-YEAR FOLLOW-UP STUDY OF a LARGE INTERNATIONAL COHORT.  Author URL.
Bowman P, Shepherd MH, Babiker T, Flanagan SE, Houghton JAL, Mathews F, Patel KA, Thomas NJ, Ellard S, Hattersley AT, et al (2017). Sulphonylureas are a highly effective long-term treatment for <i>KCNJ11</i> neonatal diabetes: the first 10 year follow-up study of a large international cohort.  Author URL.
Day JO, Torrens L, Bowman P, Shepherd M, Chakera A, Hattersley AT, Zeman AJ (2016). <i>KCNJ11</i> mutations can result in severe cognitive and behavioural problems as well as neonatal diabetes: evaluation of seven adult patients.  Author URL.
Day J, Torrens L, Bowman P, Shepherd M, Chakera A, Hattersley A, Zeman A (2016). KCNJ11 MUTATIONS CAUSE SEVERE NEUROPSYCHOLOGICAL DEFICITS.  Author URL.
Shields BM, McDonald TJ, Bowman P, Jones AG, Besser REJ, Wensley KJ, Githens-Mazer G, Knight BA, Hattersley AT (2010). Urinary C-Peptide Creatinine Ratio (UCPCR) is a Reliable Measure of Endogenous Insulin Secretion, Even in Patients with Renal Impairment.  Author URL.

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Office Hours:

Monday - Friday 9-5pm, half time research and half time clinical practice

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