COLLEGE OF MEDICINE AND HEALTH
Medicine, Nursing and Allied Health Professions

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Dr Pamela Bowman

Dr Pamela Bowman

Clinical Research Fellow

 01392 408325

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Currently undertaking research in neonatal diabetes funded by a Diabetes UK Sir George Alberti Clinical Research Training Fellowship. 

Qualifications

MBBS MA(Cantab) MSc (Dist) PhD MRCPCH MRCPsych

Research group links

Research

Research interests

Neonatal diabetes, monogenic diabetes, paediatric liaison psychiatry, neurodevelopmental disorders

Research projects

The FoND study - Assessing the Effect of Food Composition on Postprandial Insulin Secretion in Neonatal Diabetes (FoND) - ClinicalTrials.gov Identifier: NCT02921906

Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes (SuResponsKIR) - ClinicalTrials.gov Identifier: NCT02624817

Research grants

  • 2017 Humane Society
    'Roadmaps to human biology-based disease research' review article grant
  • 2016 Diabetes UK
    Diabetes UK Sir George Alberti Clinical Research Training Fellowship

Links


Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Novak A, Bowman P, Kraljevic I, Tripolski M, Houghton JAL, De Franco E, Shepherd MH, Skrabic V, Patel KA (2020). Transient Neonatal Diabetes: an Etiologic Clue for the Adult Diabetologist. Can J Diabetes, 44(2), 128-130. Author URL.
De Franco E, Saint‐Martin C, Brusgaard K, Knight Johnson AE, Aguilar‐Bryan L, Bowman P, Arnoux J, Larsen AR, Sanyoura M, Greeley SAW, et al (2020). Update of variants identified in the pancreatic β‐cell K. ATP. channel genes. KCNJ11. and. ABCC8. in individuals with congenital hyperinsulinism and diabetes. Human Mutation, 41(5), 884-905. Full text.
Bowman P, Day J, Torrens L, Shepherd MH, Knight BA, Ford TJ, Flanagan SE, Chakera A, Hattersley AT, Zeman A, et al (2019). Cognitive, Neurological, and Behavioral Features in Adults with KCNJ11 Neonatal Diabetes. Diabetes Care, 42(2), 215-224. Abstract.  Author URL.  Full text.
Bowman P, McDonald TJ, Knight BA, Flanagan SE, Leveridge M, Spaull SR, Shields BM, Hammersley S, Shepherd MH, Andrews RC, et al (2019). Patterns of postmeal insulin secretion in individuals with sulfonylurea-treated KCNJ11 neonatal diabetes show predominance of non-K ATP -channel pathways. BMJ Open Diabetes Research and Care, 7(1). Abstract.  Full text.
Bowman P, Sulen Å, Barbetti F, Beltrand J, Svalastoga P, Codner E, Tessmann EH, Juliusson PB, Skrivarhaug T, Pearson ER, et al (2018). Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study. Lancet Diabetes Endocrinol, 6(8), 637-646. Abstract.  Author URL.  Full text.
Bowman P, Flanagan SE, Hattersley AT (2018). Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity. JOURNAL OF DIABETES RESEARCH Author URL.  Full text.
Bowman P, Hattersley AT, Knight BA, Broadbridge E, Pettit L, Reville M, Flanagan SE, Shepherd MH, Ford TJ, Tonks J, et al (2017). Neuropsychological impairments in children with KCNJ11 neonatal diabetes. Diabet Med, 34(8), 1171-1173. Author URL.  Full text.
Clissold RL, Shaw-Smith C, Turnpenny P, Bunce B, Bockenhauer D, Kerecuk L, Waller S, Bowman P, Ford T, Ellard S, et al (2016). Chromosome 17q12 microdeletions but not intragenic HNF1B mutations link developmental kidney disease and psychiatric disorder. Kidney Int, 90(1), 203-211. Abstract.  Author URL.  Full text.
Bowman P, Broadbridge E, Knight BA, Pettit L, Flanagan SE, Reville M, Tonks J, Shepherd MH, Ford TJ, Hattersley AT, et al (2016). Psychiatric morbidity in children with KCNJ11 neonatal diabetes. Diabet Med, 33(10), 1387-1391. Abstract.  Author URL.  Full text.
Bowman P, Broadbridge E, Knight BA, Pettit L, Flanagan SE, Reville M, Tonks J, Shepherd MH, Ford TJ, Hattersley AT, et al (2016). Specific psychiatric disorders can be identified using systematic assessment in patients with KCNJ11 neonatal diabetes. DIABETIC MEDICINE, 33, 172-173. Author URL.
Bowman P, Knight BA, Petit L, Broadbridge E, Reville MC, Ford TJ, Tonks J, Hattersley AT (2015). Characterising the neuropsychological and psychiatric impact of potassium channel mutations on patients and their families: implications for clinical practice. DIABETIC MEDICINE, 32, 185-185. Author URL.
Bowman P, Osborne NJ, Sturley R, Vaidya B (2012). Carbimazole embryopathy: implications for the choice of antithyroid drugs in pregnancy. QJM, 105(2), 189-193. Abstract.  Author URL.
Bowman P, Flanagan SE, Edghill EL, Damhuis A, Shepherd MH, Paisey R, Hattersley AT, Ellard S (2012). Heterozygous ABCC8 mutations are a cause of MODY. Diabetologia, 55(1), 123-127. Abstract.  Author URL.
Bowman P, Quinn M (2012). Question 1: Should steroids be used to treat abdominal pain caused by Henoch-Schonlein purpura?. Arch Dis Child, 97(11), 999-1000. Author URL.
Thomas NJ, Shields BM, Besser REJ, Jones AG, Rawlingson A, Goodchild E, Leighton C, Bowman P, Shepherd M, Knight BA, et al (2012). The impact of gender on urine C-peptide creatinine ratio interpretation. Ann Clin Biochem, 49(Pt 4), 363-368. Abstract.  Author URL.
Bowman P, McDonald TJ, Shields BM, Knight BA, Hattersley AT (2012). Validation of a single-sample urinary C-peptide creatinine ratio as a reproducible alternative to serum C-peptide in patients with Type 2 diabetes. Diabet Med, 29(1), 90-93. Abstract.  Author URL.
Bowman P, Vaidya B (2011). Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy. J Thyroid Res, 2011 Abstract.  Author URL.  Full text.
Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman P, Oram RA, Knight BA, Hattersley AT (2011). Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. Diabet Med, 28(9), 1034-1038. Abstract.  Author URL.
McDonald TJ, Knight BA, Shields BM, Bowman P, Salzmann MB, Hattersley AT (2009). Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide. Clin Chem, 55(11), 2035-2039. Abstract.  Author URL.

Conferences

Bowman P, Patel KA, McDonald TJ, Knight BA, Leveridge M, Flanagan SE, Hammersley S, Shepherd MH, Andrews RC, Hattersley AT, et al (2019). Physiological assessment of individuals with sulphonylurea-treated KCNJ11 permanent neonatal diabetes following carbohydrate and protein meals shows markedly reduced KATP mediated insulin secretion but relatively intact non-KATP pathways.  Author URL.
Bowman P, Shepherd MH, McDonald TJ, Andrews RC, Spaull SR, Statton S, Hammersley S, Leveridge M, Shields BM, Flanagan SE, et al (2018). Excess insulin secretion with a high protein meal in sulphonylurea treated KCNJ11 neonatal diabetes patients shows the limitations of amplifying insulin secretion pathways.  Author URL.
Bowman P, Sulen A, Barbetti F, Beltrand J, Polak M, Iafusco D, Svalastoga P, Skrivarhaug T, Klimes I, Codner E, et al (2017). SULPHONYLUREAS ARE a HIGHLY EFFECTIVE AND SAFE LONG-TERM TREATMENT FOR NEONATAL DIABETES DUE TO KCNJ11 MUTATIONS: THE FIRST 10-YEAR FOLLOW-UP STUDY OF a LARGE INTERNATIONAL COHORT.  Author URL.
Bowman P, Shepherd MH, Babiker T, Flanagan SE, Houghton JAL, Mathews F, Patel KA, Thomas NJ, Ellard S, Hattersley AT, et al (2017). Sulphonylureas are a highly effective long-term treatment for KCNJ11 neonatal diabetes: the first 10 year follow-up study of a large international cohort.  Author URL.
Day J, Torrens L, Bowman P, Shepherd M, Chakera A, Hattersley A, Zeman A (2016). KCNJ11 MUTATIONS CAUSE SEVERE NEUROPSYCHOLOGICAL DEFICITS.  Author URL.
Day JO, Torrens L, Bowman P, Shepherd M, Chakera A, Hattersley AT, Zeman AJ (2016). KCNJ11 mutations can result in severe cognitive and behavioural problems as well as neonatal diabetes: evaluation of seven adult patients.  Author URL.
Shields BM, McDonald TJ, Bowman P, Jones AG, Besser REJ, Wensley KJ, Githens-Mazer G, Knight BA, Hattersley AT (2010). Urinary C-Peptide Creatinine Ratio (UCPCR) is a Reliable Measure of Endogenous Insulin Secretion, Even in Patients with Renal Impairment.  Author URL.

Publications by year


2020

Bowman P (2020). Assessing the glycaemic and CNS response to sulphonylurea therapy in patients with KCNJ11 mutations.  Abstract.  Full text.
Novak A, Bowman P, Kraljevic I, Tripolski M, Houghton JAL, De Franco E, Shepherd MH, Skrabic V, Patel KA (2020). Transient Neonatal Diabetes: an Etiologic Clue for the Adult Diabetologist. Can J Diabetes, 44(2), 128-130. Author URL.
De Franco E, Saint‐Martin C, Brusgaard K, Knight Johnson AE, Aguilar‐Bryan L, Bowman P, Arnoux J, Larsen AR, Sanyoura M, Greeley SAW, et al (2020). Update of variants identified in the pancreatic β‐cell K. ATP. channel genes. KCNJ11. and. ABCC8. in individuals with congenital hyperinsulinism and diabetes. Human Mutation, 41(5), 884-905. Full text.

2019

Bowman P, Day J, Torrens L, Shepherd MH, Knight BA, Ford TJ, Flanagan SE, Chakera A, Hattersley AT, Zeman A, et al (2019). Cognitive, Neurological, and Behavioral Features in Adults with KCNJ11 Neonatal Diabetes. Diabetes Care, 42(2), 215-224. Abstract.  Author URL.  Full text.
Bowman P, McDonald TJ, Knight BA, Flanagan SE, Leveridge M, Spaull SR, Shields BM, Hammersley S, Shepherd MH, Andrews RC, et al (2019). Patterns of postmeal insulin secretion in individuals with sulfonylurea-treated KCNJ11 neonatal diabetes show predominance of non-K ATP -channel pathways. BMJ Open Diabetes Research and Care, 7(1). Abstract.  Full text.
Bowman P, Patel KA, McDonald TJ, Knight BA, Leveridge M, Flanagan SE, Hammersley S, Shepherd MH, Andrews RC, Hattersley AT, et al (2019). Physiological assessment of individuals with sulphonylurea-treated KCNJ11 permanent neonatal diabetes following carbohydrate and protein meals shows markedly reduced KATP mediated insulin secretion but relatively intact non-KATP pathways.  Author URL.

2018

Bowman P, Sulen Å, Barbetti F, Beltrand J, Svalastoga P, Codner E, Tessmann EH, Juliusson PB, Skrivarhaug T, Pearson ER, et al (2018). Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study. Lancet Diabetes Endocrinol, 6(8), 637-646. Abstract.  Author URL.  Full text.
Bowman P, Shepherd MH, McDonald TJ, Andrews RC, Spaull SR, Statton S, Hammersley S, Leveridge M, Shields BM, Flanagan SE, et al (2018). Excess insulin secretion with a high protein meal in sulphonylurea treated KCNJ11 neonatal diabetes patients shows the limitations of amplifying insulin secretion pathways.  Author URL.
Bowman P, Flanagan SE, Hattersley AT (2018). Future Roadmaps for Precision Medicine Applied to Diabetes: Rising to the Challenge of Heterogeneity. JOURNAL OF DIABETES RESEARCH Author URL.  Full text.

2017

Bowman P, Hattersley AT, Knight BA, Broadbridge E, Pettit L, Reville M, Flanagan SE, Shepherd MH, Ford TJ, Tonks J, et al (2017). Neuropsychological impairments in children with KCNJ11 neonatal diabetes. Diabet Med, 34(8), 1171-1173. Author URL.  Full text.
Bowman P, Sulen A, Barbetti F, Beltrand J, Polak M, Iafusco D, Svalastoga P, Skrivarhaug T, Klimes I, Codner E, et al (2017). SULPHONYLUREAS ARE a HIGHLY EFFECTIVE AND SAFE LONG-TERM TREATMENT FOR NEONATAL DIABETES DUE TO KCNJ11 MUTATIONS: THE FIRST 10-YEAR FOLLOW-UP STUDY OF a LARGE INTERNATIONAL COHORT.  Author URL.
Bowman P, Shepherd MH, Babiker T, Flanagan SE, Houghton JAL, Mathews F, Patel KA, Thomas NJ, Ellard S, Hattersley AT, et al (2017). Sulphonylureas are a highly effective long-term treatment for KCNJ11 neonatal diabetes: the first 10 year follow-up study of a large international cohort.  Author URL.

2016

Clissold RL, Shaw-Smith C, Turnpenny P, Bunce B, Bockenhauer D, Kerecuk L, Waller S, Bowman P, Ford T, Ellard S, et al (2016). Chromosome 17q12 microdeletions but not intragenic HNF1B mutations link developmental kidney disease and psychiatric disorder. Kidney Int, 90(1), 203-211. Abstract.  Author URL.  Full text.
Day J, Torrens L, Bowman P, Shepherd M, Chakera A, Hattersley A, Zeman A (2016). KCNJ11 MUTATIONS CAUSE SEVERE NEUROPSYCHOLOGICAL DEFICITS.  Author URL.
Day JO, Torrens L, Bowman P, Shepherd M, Chakera A, Hattersley AT, Zeman AJ (2016). KCNJ11 mutations can result in severe cognitive and behavioural problems as well as neonatal diabetes: evaluation of seven adult patients.  Author URL.
Bowman P, Broadbridge E, Knight BA, Pettit L, Flanagan SE, Reville M, Tonks J, Shepherd MH, Ford TJ, Hattersley AT, et al (2016). Psychiatric morbidity in children with KCNJ11 neonatal diabetes. Diabet Med, 33(10), 1387-1391. Abstract.  Author URL.  Full text.
Bowman P, Broadbridge E, Knight BA, Pettit L, Flanagan SE, Reville M, Tonks J, Shepherd MH, Ford TJ, Hattersley AT, et al (2016). Specific psychiatric disorders can be identified using systematic assessment in patients with KCNJ11 neonatal diabetes. DIABETIC MEDICINE, 33, 172-173. Author URL.

2015

Bowman P, Knight BA, Petit L, Broadbridge E, Reville MC, Ford TJ, Tonks J, Hattersley AT (2015). Characterising the neuropsychological and psychiatric impact of potassium channel mutations on patients and their families: implications for clinical practice. DIABETIC MEDICINE, 32, 185-185. Author URL.

2012

Bowman P, Osborne NJ, Sturley R, Vaidya B (2012). Carbimazole embryopathy: implications for the choice of antithyroid drugs in pregnancy. QJM, 105(2), 189-193. Abstract.  Author URL.
Bowman P, Flanagan SE, Edghill EL, Damhuis A, Shepherd MH, Paisey R, Hattersley AT, Ellard S (2012). Heterozygous ABCC8 mutations are a cause of MODY. Diabetologia, 55(1), 123-127. Abstract.  Author URL.
Bowman P, Quinn M (2012). Question 1: Should steroids be used to treat abdominal pain caused by Henoch-Schonlein purpura?. Arch Dis Child, 97(11), 999-1000. Author URL.
Thomas NJ, Shields BM, Besser REJ, Jones AG, Rawlingson A, Goodchild E, Leighton C, Bowman P, Shepherd M, Knight BA, et al (2012). The impact of gender on urine C-peptide creatinine ratio interpretation. Ann Clin Biochem, 49(Pt 4), 363-368. Abstract.  Author URL.
Bowman P, McDonald TJ, Shields BM, Knight BA, Hattersley AT (2012). Validation of a single-sample urinary C-peptide creatinine ratio as a reproducible alternative to serum C-peptide in patients with Type 2 diabetes. Diabet Med, 29(1), 90-93. Abstract.  Author URL.

2011

Bowman P, Vaidya B (2011). Suspected Spontaneous Reports of Birth Defects in the UK Associated with the Use of Carbimazole and Propylthiouracil in Pregnancy. J Thyroid Res, 2011 Abstract.  Author URL.  Full text.
Jones AG, Besser REJ, McDonald TJ, Shields BM, Hope SV, Bowman P, Oram RA, Knight BA, Hattersley AT (2011). Urine C-peptide creatinine ratio is an alternative to stimulated serum C-peptide measurement in late-onset, insulin-treated diabetes. Diabet Med, 28(9), 1034-1038. Abstract.  Author URL.

2010

Shields BM, McDonald TJ, Bowman P, Jones AG, Besser REJ, Wensley KJ, Githens-Mazer G, Knight BA, Hattersley AT (2010). Urinary C-Peptide Creatinine Ratio (UCPCR) is a Reliable Measure of Endogenous Insulin Secretion, Even in Patients with Renal Impairment.  Author URL.

2009

McDonald TJ, Knight BA, Shields BM, Bowman P, Salzmann MB, Hattersley AT (2009). Stability and reproducibility of a single-sample urinary C-peptide/creatinine ratio and its correlation with 24-h urinary C-peptide. Clin Chem, 55(11), 2035-2039. Abstract.  Author URL.

Pamela_Bowman Details from cache as at 2020-08-06 20:20:47

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