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University of Exeter Medical School

Professor Noel Morgan

Professor Noel Morgan

Professor of Endocrine Pharmacology; Director - Institute of Biomedical & Clinical Science

 01392 408300

 RILD Building 4.10


University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK


Professor Morgan has a background in cellular pharmacology and his research career has focussed principally on the (patho)physiology of the pancreatic beta-cell in the context of both type 1 and type 2 diabetes. Within the University of Exeter Medical School he leads a team studying the regulation of beta-cell function and viability with the aim to understand how dysfunction and loss of viability lead to clinical disease. His research team are custodians of a unique and extensive biobank of pancreas samples collected from children and young people who, sadly, died soon after the diagnosis of type 1 diabetes. Using these samples, the team has made important contributions to the understanding of insulitis (a process of immune-mediated attack) in human pancreas and to the role of a group of common viruses (enteroviruses) as potential mediators of beta-cell loss in type 1 diabetes. They have also discovered that type 1 diabetes is not a single disease but, rather, they have identified two distinct forms (or "endotypes") which can be differentiated in various ways, including by age at diagnosis. This information will be important to inform the design of therapies aimed to halt the progression of type 1 diabetes using a precision diabetes approach, in future.

Noel also serves as Director of the Institute of Biomedical and Clinical Science and is involved in developing the strategic vision of the Institute as well as the achievement of its research mission. This involves resource allocation, strategic planning, recruitment, undertaking staff appraisals and facilitation of the career aspirations of staff at all levels.

Broad research specialisms

His team's research specialisms include the monitoring and assessment of cell function and viability using in vitro approaches; the manipulation of intracellular signalling pathways using both pharmacological and molecular biological approaches; and the application of digital pathology and immunological methods to understand disease pathology in histological samples.


  • B.Sc. (Hons)
  • Ph.D.


Noel Morgan began his research career studying islet biology at University of Leicester and then undertook postdoctoral work on the hormonal control of liver glycogenolysis at Vanderbilt University (Nashville, TN). He subsequently developed an independent research programme in islet biology while on the faculty of Keele University (UK). Noel was awarded an inaugural Albert E. Renold Fellowship of EASD in 1990 to work in the laboratory of Robert J Lefkowitz (2012 Nobel laureate) at Duke University, Durham, NC studying adrenoceptor signalling in beta-cells. He was appointed to a Personal Chair at Keele University in 1993 and moved to University of Exeter, in 2002, as Professor of Endocrine Pharmacology. At Exeter, his group has pursued parallel studies on signaling mechanisms regulating β-cell function and viability as well as factors that underlie the loss of β-cells in type 1 diabetes. In 2017, Noel was awarded the prestigious Dorothy Hodgkin Lectureship by Diabetes UK in recogntion of his work.

Secretary contact details: Nikki Archer, +44 (0) 1392 408215


Research group links

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Research interests

Professor Morgan's team has research interests which centre around the mechanisms that lead to beta-cell dysfunction and death in both type 1 and type 2 diabetes. Their work in type 1 diabetes makes use of a unique cohort of pancreas samples recovered from patients who died soon after diagnosis, to study the natural history of the disease. They are investigating the immune cell composition of the infiltrate that is associated with beta-cell loss (known as “insulitis”) and are also studying the possible involvement of an enteroviral infection as a mediator of islet autoimmunty. The anti-viral mechanisms that become activated in beta-cells during such infections are a particular focus of investigation.

In addition, they employ cell culture models to study the role of fatty acids as regulators of beta-cell viability. Patients with type 2 diabetes often have elevated levels of long chain free fatty acids and these can cause beta-cell death. Their work has revealed that the effects of such molecules on viability are influenced greatly by the chain length and degree of unsaturation of the fatty acid molecules. Indeed, it is evident that long chain saturated species are frequently cytotoxic whereas the equivalent long chain unsaturates (both mono- and poly-) are well tolerated and can even be cytoprotective. They are currently studying the mechanisms involved.

A third area of interest is the signalling pathways used by anti-inflammatory cytokines, such as interleukin-4 and interleukin-13 to promote beta-cell viability. These molecules regulate the activity of a family of transcription factors (STATs) and they are examining exactly how various STAT isoforms become activated and the mechanisms that then lead to improved viability. In parallel, they are also studying the pro-apoptotic actions of other STAT family members to understand how these proteins cause differential effects on beta-cell viability.

Professor Morgan gives an overview of his research in the video below, in a joint presentation with Kyle Wedgwood, filmed at the Living Systems Institute Symposium 2016.

Research projects

  • Beta-cell enteroviral infection and the progression of type 1 diabetes in humans
  • Role of pathogen recognition receptors and anti-viral response pathways in the response of islets cells to enteroviral infection
  • Immune cell subsets as mediators of the selective demise of beta-cells in human type 1 diabetes
  • Endotypes of type 1 diabetes
  • Factors influencing the uptake and disposition of long chain fatty acids in pancreatic beta-cells
  • Mechanisms involved in the cytoprotective actions of unsaturated fatty acids in beta-cells
  • The role of STAT molecules as regulators of beta-cell viability during exposure to pro- and anti-inflammatory cytokines


2017-2021     MRC. Type 1 diabetes genetic risk and persistent beta cell enteroviral infection - a lethal combination? £392000. (Co-I; Dr Sarah Richardson (PI) and Prof Lorna Harries (Co-I)).

2017-2020     Diabetes UK. Characterisation of immune cell interactions in the insulitic infiltrate of patients with recent-onset Type 1 diabetes. £164000. (PI)

2017-2020         JDRF. The JDRF nPOD-Virus Group: Towards Vaccine Development. $144000. (Co-I).

2017-2021     Norman Family Trust. Enteroviral infection in human beta cells: a possible causative factor in type 1 diabetes. £90000. (Co-I).

2018-2021     JDRF Strategic Research Award: Phenotype and specificity of the islet inflammation in Type 1 diabetes: $349630. (Co-I).

2019-2021     Research England – Expanding Excellence in England award for establishment of a Diabetes Centre of Excellence. £6million to University of Exeter (Co-PI).

2019-2020     EFSD/JDRF/Lilly European Programme in Type 1 Diabetes Research: SIRP alpha, a novel regulator of beta-cell viability. €99,500 (PI).

2019-2022     INNODIA & INNODIA-HARVEST a multi-partner joint programme within EU Horizon 2020. Total award – Euro 6 million (Euro 100000 to University of Exeter) (Co-PI).

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Journal articles

Wakeling M, Owens NDL, Hopkinson JR, Johnson MB, Houghton JAL, Dastamani A, Flaxman CS, Wyatt RC, Hewat TI, Hopkins JJ, et al (In Press). A novel disease mechanism leading to the expression of a disallowed gene in the pancreatic beta-cell identified by non-coding, regulatory mutations controlling HK1. Nature Genetics Abstract.
Morgan N (In Press). Temporal Regulation of interferon signalling in human EndoC-betaH1 cells. Journal of Molecular Endocrinology
Morgan NG (2024). Insulitis in human type 1 diabetes: lessons from an enigmatic lesion. Eur J Endocrinol, 190(1), R1-R9. Abstract.  Author URL.
Torabi F, Vadakekolathu J, Wyatt R, Leete P, Tombs MA, Richardson CC, Boocock DJ, Turner MD, Morgan NG, Richardson SJ, et al (2023). Differential expression of genes controlling lymphocyte differentiation and migration in two distinct endotypes of type 1 diabetes. Diabet Med, 40(9). Abstract.  Author URL.
Boldison J, Hopkinson JR, Davies J, Pearson JA, Leete P, Richardson S, Morgan NG, Wong FS (2023). Gene expression profiling in NOD mice reveals that B cells are highly educated by the pancreatic environment during autoimmune diabetes. Diabetologia, 66(3), 551-566. Abstract.
Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, et al (2023). Gene expression signature predicts rate of type 1 diabetes progression. eBioMedicine, 92 Abstract.
Redondo MJ, Morgan NG (2023). Heterogeneity and endotypes in type 1 diabetes mellitus. Nat Rev Endocrinol, 19(9), 542-554. Abstract.  Author URL.
Russell MA, Richardson SJ, Morgan NG (2023). The role of the interferon/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes. Front Endocrinol (Lausanne), 14 Abstract.  Author URL.
Carr ALJ, Inshaw JRJ, Flaxman CS, Leete P, Wyatt RC, Russell LA, Palmer M, Prasolov D, Worthington T, Hull B, et al (2022). Circulating C-Peptide Levels in Living Children and Young People and Pancreatic β-Cell Loss in Pancreas Donors Across Type 1 Diabetes Disease Duration. Diabetes, 71(7), 1591-1596. Abstract.
Krogvold L, Leete P, Mynarek IM, Russell MA, Gerling IC, Lenchik NI, Mathews C, Richardson SJ, Morgan NG, Dahl-Jørgensen K, et al (2022). Detection of Antiviral Tissue Responses and Increased Cell Stress in the Pancreatic Islets of Newly Diagnosed Type 1 Diabetes Patients: Results from the DiViD Study. Frontiers in Endocrinology, 13 Abstract.
Sioofy-Khojine A-B, Richardson SJ, Locke JM, Oikarinen S, Nurminen N, Laine A-P, Downes K, Lempainen J, Todd JA, Veijola R, et al (2022). Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage. Diabetologia, 65(10), 1701-1709. Abstract.
Thomas P, Arden C, Corcoran J, Hacker C, Welters HJ, Morgan NG (2022). Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells. Nutr Diabetes, 12(1). Abstract.  Author URL.
Morgan NG, Richardson SJ, Powers AC, Saunders DC, Brissova M (2022). Images from the Exeter Archival Diabetes Biobank Now Accessible via Pancreatlas. Diabetes Care, 45(12), e174-e175.
Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG (2022). Temporal regulation of interferon signalling in human EndoC-βH1 cells. J Mol Endocrinol, 69(2), 299-313. Abstract.  Author URL.
Rodriguez-Calvo T, Chen Y-C, Verchere CB, Haataja L, Arvan P, Leete P, Richardson SJ, Morgan NG, Qian W-J, Pugliese A, et al (2021). Altered β-Cell Prohormone Processing and Secretion in Type 1 Diabetes. Diabetes, 70(5), 1038-1050. Abstract.  Author URL.
Leete P, Morgan NG (2021). Footprints of Immune Cells in the Pancreas in Type 1 Diabetes; to "B" or Not to "B": is That Still the Question?. Front Endocrinol (Lausanne), 12 Abstract.  Author URL.
Weider T, Richardson SJ, Morgan NG, Paulsen TH, Dahl-Jørgensen K, Hammerstad SS (2021). HLA Class I Upregulation and Antiviral Immune Responses in Graves Disease. J Clin Endocrinol Metab, 106(4), e1763-e1774. Abstract.  Author URL.
Korpos É, Kadri N, Loismann S, Findeisen CR, Arfuso F, Burke GW, Richardson SJ, Morgan NG, Bogdani M, Pugliese A, et al (2021). Identification and characterisation of tertiary lymphoid organs in human type 1 diabetes. Diabetologia, 64(7), 1626-1641. Abstract.  Author URL.
Chaffey JR, Young J, Leslie KA, Partridge K, Akhbari P, Dhayal S, Hill JL, Wedgwood KCA, Burnett E, Russell MA, et al (2021). Investigation of the utility of the 1.1B4 cell as a model human beta cell line for study of persistent enteroviral infection. Sci Rep, 11(1). Abstract.  Author URL.
Thomas P, Leslie KA, Welters HJ, Morgan NG (2021). Long-chain saturated fatty acid species are not toxic to human pancreatic β-cells and may offer protection against pro-inflammatory cytokine induced β-cell death. NUTRITION & METABOLISM, 18(1). Author URL.
Colli ML, Ramos-Rodríguez M, Nakayasu ES, Alvelos MI, Lopes M, Hill JLE, Turatsinze J-V, Coomans de Brachène A, Russell MA, Raurell-Vila H, et al (2020). An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells. Nat Commun, 11(1). Abstract.  Author URL.
White MG, Maheshwari RR, Anderson SJ, Berlinguer-Palmini R, Jones C, Richardson SJ, Rotti PG, Armour SL, Ding Y, Krasnogor N, et al (2020). In Situ Analysis Reveals That CFTR is Expressed in Only a Small Minority of β-Cells in Normal Adult Human Pancreas. J Clin Endocrinol Metab, 105(5), 1366-1374. Abstract.  Author URL.
Battaglia M, Ahmed S, Anderson MS, Atkinson MA, Becker D, Bingley PJ, Bosi E, Brusko TM, DiMeglio LA, Evans-Molina C, et al (2020). Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes. Diabetes Care, 43(1), 5-12. Abstract.  Author URL.
Thomas P, Leslie KA, Welters HJ, Morgan NG (2020). Long-chain Saturated Fatty Acid Species Are Not Toxic to Human Pancreatic Β-cells and May Offer Protection Against Pro-inflammatory Cytokine Induced β-cell Death.  Abstract.
Armour SL, Anderson SJ, Richardson SJ, Ding Y, Carey C, Lyon J, Maheshwari RR, Al-Jahdami N, Krasnogor N, Morgan NG, et al (2020). Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes is Associated with Increased Islet α-Cell Number. Endocrinology, 161(4). Abstract.  Author URL.
Leete P, Oram RA, McDonald TJ, Shields BM, Ziller C, TIGI study team, Hattersley AT, Richardson SJ, Morgan NG (2020). Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis. Diabetologia, 63(6), 1258-1267. Abstract.  Author URL.
Khilji MS, Bresson SE, Verstappen D, Pihl C, Andersen PAK, Agergaard JB, Dahlby T, Bryde TH, Klindt K, Nielsen CK, et al (2020). The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets. Am J Physiol Endocrinol Metab, 318(6), E892-E900. Abstract.  Author URL.
Akhbari P, Richardson SJ, Morgan NG (2020). Type 1 Diabetes: Interferons and the Aftermath of Pancreatic Beta-Cell Enteroviral Infection. Microorganisms, 8(9), 1419-1419. Abstract.
Weider T, Richardson SJ, Morgan NG, Paulsen TH, Dahl-Jørgensen K, Hammerstad SS (2020). Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis. Thyroid, 30(3), 432-442. Abstract.  Author URL.
Viloria K, Nasteska D, Briant LJB, Heising S, Larner DP, Fine NHF, Ashford FB, da Silva Xavier G, Ramos MJ, Hasib A, et al (2020). Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion. Cell Rep, 31(11). Abstract.  Author URL.
Jeffery N, Richardson S, Chambers D, Morgan NG, Harries LW (2019). Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns. Hum Mol Genet, 28(16), 2763-2774. Abstract.  Author URL.
Dhayal S, Zummo FP, Anderson MW, Thomas P, Welters HJ, Arden C, Morgan NG (2019). Differential effects of saturated and unsaturated fatty acids on autophagy in pancreatic β-cells. J Mol Endocrinol, 63(4), 285-296. Abstract.  Author URL.
Bahal S, Houssen ME, Manson A, Lorenzo L, Russell MA, Morgan NG, Tahami F, Grigoriadou S (2019). Evidence that a STAT3 Mutation Causing Hyper IgE Syndrome Leads to Repression of Transcriptional Activity. Case Reports Immunol, 2019 Abstract.  Author URL.
Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, et al (2019). HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells from Donors with Type 1 Diabetes. Diabetes, 68(5), 988-1001. Abstract.  Author URL.
Basile G, Kulkarni RN, Morgan NG (2019). How, When, and Where Do Human β-Cells Regenerate?. Curr Diab Rep, 19(8). Abstract.  Author URL.
Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Lloyd RE, Morgan NG, Pugliese A, et al (2019). Large enteroviral vaccination studies to prevent type 1 diabetes should be well founded and rely on scientific evidence. Reply to Skog O, Klingel K, Roivainen M et al [letter]. Diabetologia, 62(6), 1100-1103. Author URL.
King R, Hill JL, Saha B, Tong Y, Strutt BJ, Russell MA, Morgan NG, Richardson SJ, Hill DJ (2019). Offspring of Mice Exposed to a Low-Protein Diet in Utero Demonstrate Changes in mTOR Signaling in Pancreatic Islets of Langerhans, Associated with Altered Glucagon and Insulin Expression and a Lower β-Cell Mass. Nutrients, 11(3). Abstract.  Author URL.
Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, et al (2019). Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes. Diabetologia, 62(5), 744-753. Abstract.  Author URL.
Leslie KA, Russell MA, Taniguchi K, Richardson SJ, Morgan NG (2019). The transcription factor STAT6 plays a critical role in promoting beta cell viability and is depleted in islets of individuals with type 1 diabetes. Diabetologia, 62(1), 87-98. Abstract.  Author URL.
Viloria K, Nasteska D, Larner D, Fine N, Ashford F, Heising S, Xavier GDS, Briant L, Flaxman C, Morgan N, et al (2019). Vitamin D-binding protein is required for the maintenance of [alpha]-cell identity and function. Endocrine Abstracts
Viloria K, Nasteska D, Briant LJB, Heising S, Larner D, Fine NHF, Ashford FB, Silva Xavier GD, Ramos MJ, Manning Fox JE, et al (2019). Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion.  Abstract.
Russell MA, Pigors M, Houssen ME, Manson A, Kelsell D, Longhurst H, Morgan NG (2018). A novel de novo activating mutation in STAT3 identified in a patient with common variable immunodeficiency (CVID). Clin Immunol, 187, 132-136. Abstract.  Author URL.
Holm LJ, Krogvold L, Hasselby JP, Kaur S, Claessens LA, Russell MA, Mathews CE, Hanssen KF, Morgan NG, Koeleman BPC, et al (2018). Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia, 61(7), 1650-1661. Abstract.  Author URL.
Vecchio F, Lo Buono N, Stabilini A, Nigi L, Dufort MJ, Geyer S, Rancoita PM, Cugnata F, Mandelli A, Valle A, et al (2018). Abnormal neutrophil signature in the blood and pancreas of presymptomatic and symptomatic type 1 diabetes. JCI Insight, 3(18). Abstract.  Author URL.
Shields B, McDonald T, Oram R, Hill A, Hudson M, Leete P, Pearson E, Richardson S, Morgan N, Hattersley A, et al (2018). C-peptide decline in type 1 diabetes has two phases: an initial exponential fall and a subsequent stable phase. Diabetes Care
Oikarinen M, Laiho JE, Oikarinen S, Richardson SJ, Kusmartseva I, Campbell-Thompson M, Morgan NG, Pugliese A, Tauriainen S, Toniolo A, et al (2018). Detection of enterovirus protein and RNA in multiple tissues from nPOD organ donors with type 1 diabetes.  Abstract.
Richardson SJ, Morgan NG (2018). Enteroviral infections in the pathogenesis of type 1 diabetes: new insights for therapeutic intervention. Current Opinion in Pharmacology, 43, 11-19.
Morgan NG, Richardson SJ (2018). Fifty years of pancreatic islet pathology in human type 1 diabetes: insights gained and progress made. Diabetologia, 61(12), 2499-2506.
Kronenberg-Versteeg D, Eichmann M, Russell MA, Ru AD, Hehn B, Yusuf N, Veelen PAV, Richardson SJ, Morgan NG, Lemberg MK, et al (2018). Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 diabetes. Diabetes, 67(4), 687-696. Abstract.
Colli ML, Hill JLE, Marroquí L, Chaffey J, Dos Santos RS, Leete P, Coomans de Brachène A, Paula FMM, Op de Beeck A, Castela A, et al (2018). PDL1 is expressed in the islets of people with type 1 diabetes and is up-regulated by interferons-α and-γ via IRF1 induction. EBioMedicine, 36, 367-375. Abstract.  Author URL.
Ifie E, Russell MA, Dhayal S, Leete P, Sebastiani G, Nigi L, Dotta F, Marjomäki V, Eizirik DL, Morgan NG, et al (2018). Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells. Diabetologia, 61(11), 2344-2355.
Saarimäki-Vire J, Balboa D, Russell MA, Saarikettu J, Kinnunen M, Keskitalo S, Malhi A, Valensisi C, Andrus C, Eurola S, et al (2017). An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation. Cell Rep, 19(2), 281-294. Abstract.  Author URL.
Morgan NG (2017). Bringing the human pancreas into focus: new paradigms for the understanding of Type 1 diabetes. Diabet Med, 34(7), 879-886. Abstract.  Author URL.
Busse N, Paroni F, Richardson SJ, Laiho JE, Oikarinen M, Frisk G, Hyöty H, de Koning E, Morgan NG, Maedler K, et al (2017). Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes. Oncotarget, 8(8), 12620-12636. Abstract.  Author URL.
Willcox A, Richardson SJ, Walker LSK, Kent SC, Morgan NG, Gillespie KM (2017). Germinal centre frequency is decreased in pancreatic lymph nodes from individuals with recent-onset type 1 diabetes. Diabetologia, 60(7), 1294-1303. Abstract.
Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, et al (2017). Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?. Diabetologia, 60(4), 753-755.
Dharmadhikari G, Stolz K, Hauke M, Morgan NG, Varki A, de Koning E, Kelm S, Maedler K (2017). Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes. Sci Rep, 7 Abstract.  Author URL.
Wagner FF, Lundh M, Kaya T, McCarren P, Zhang Y-L, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, et al (2016). An Isochemogenic Set of Inhibitors to Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection. ACS Chem Biol, 11(2), 363-374. Abstract.  Author URL.
Morgan N, Richardson S (2016). Changing perspectives on the progression of type 1 diabetes. Practical Diabetes, 33(4), 118-120.
Leete P, Willcox A, Krogvold L, Dahl-Jørgensen K, Foulis AK, Richardson SJ, Morgan NG (2016). Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes. Diabetes, 65(5), 1362-1369. Abstract.  Author URL.
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, et al (2016). Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59(11), 2448-2458. Abstract.  Author URL.
Corcoran J, Petrov P, Whatmore J, Winlove P, Morgan NG (2016). Molecular analysis of the uptake and disposition of long chain fatty acids (LCFA) in beta cells. DIABETIC MEDICINE, 33, 81-81. Author URL.
Laiho JE, Oikarinen M, Richardson SJ, Frisk G, Nyalwidhe J, Burch TC, Morris MA, Oikarinen S, Pugliese A, Dotta F, et al (2016). Relative sensitivity of immunohistochemistry, multiple reaction monitoring mass spectrometry, in situ hybridization and PCR to detect Coxsackievirus B1 in A549 cells. Journal of Clinical Virology, 77, 21-28.
Wedgwood KCA, Richardson SJ, Morgan NG, tsaneva-atanasova K (2016). Spatiotemporal dynamics of insulitis in human type 1 diabetes. Frontiers in Physiology Abstract.
Ferru-Clément R, Spanova M, Dhayal S, Morgan NG, Hélye R, Becq F, Hirose H, Antonny B, Vamparys L, Fuchs PFJ, et al (2016). Targeting surface voids to counter membrane disorders in lipointoxication-related diseases. J Cell Sci, 129(12), 2368-2381. Abstract.  Author URL.
Krogvold L, Edwin B, Buanes T, Frisk G, Skog O, Anagandula M, Korsgren O, Undlien D, Eike MC, Richardson SJ, et al (2015). Detection of a low-grade enteroviral infection in the islets of langerhans of living patients newly diagnosed with type 1 diabetes. Diabetes, 64(5), 1682-1687. Abstract.  Author URL.
Marroqui L, Lopes M, dos Santos RS, Grieco FA, Roivainen M, Richardson SJ, Morgan NG, Op de Beeck A, Eizirik DL (2015). Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells. Elife, 4 Abstract.  Author URL.
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2015). Erratum. Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes. Diabetes 2014;63:3835-3845. Diabetes, 64(9). Author URL.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia Abstract.
Taniguchi K, Russell MA, Richardson SJ, Morgan NG (2015). The subcellular distribution of cyclin-D1 and cyclin-D3 within human islet cells varies according to the status of the pancreas donor. Diabetologia, 58(9), 2056-2063. Abstract.
Flanagan SE, Haapaniemi E, Russell MA, Caswell R, Allen HL, De Franco E, McDonald TJ, Rajala H, Ramelius A, Barton J, et al (2014). Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease. Nat Genet, 46(8), 812-814. Abstract.  Author URL.
Arif S, Leete P, Nguyen V, Marks K, Nor NM, Estorninho M, Kronenberg-Versteeg D, Bingley PJ, Todd JA, Guy C, et al (2014). Blood and islet phenotypes indicate immunological heterogeneity in type 1 diabetes. Diabetes, 63(11), 3835-3845. Abstract.  Author URL.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry? Reply to Hansson SF, Korsgren S, Pontén F et al [letter]. Diabetologia, 57(3), 647-649. Author URL.
Morgan NG, Richardson SJ (2014). Enteroviruses as causative agents in type 1 diabetes: loose ends or lost cause?. Trends Endocrinol Metab, 25(12), 611-619. Abstract.  Author URL.
Richardson SJ, Leete P, Dhayal S, Russell MA, Oikarinen M, Laiho JE, Svedin E, Lind K, Rosenling T, Chapman N, et al (2014). Evaluation of the fidelity of immunolabelling obtained with clone 5D8/1, a monoclonal antibody directed against the enteroviral capsid protein, VP1, in human pancreas. Diabetologia, 57(2), 392-401. Abstract.
Stone VM, Dhayal S, Brocklehurst KJ, Lenaghan C, Sörhede Winzell M, Hammar M, Xu X, Smith DM, Morgan NG (2014). GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans. Diabetologia, 57(6), 1182-1191. Abstract.  Author URL.
Morgan NG, Leete P, Foulis AK, Richardson SJ (2014). Islet inflammation in human type 1 diabetes mellitus. IUBMB Life, 66(11), 723-734. Abstract.  Author URL.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus. Endocrine Pathology, 25(1), 80-92. Abstract.
Richardson SJ, Morgan NG, Foulis AK (2014). Pancreatic pathology in type 1 diabetes mellitus. Endocr Pathol, 25(1), 80-92. Abstract.  Author URL.
Bjursell M, Xu X, Admyre T, Böttcher G, Lundin S, Nilsson R, Stone VM, Morgan NG, Lam YY, Storlien LH, et al (2014). The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120. PLoS One, 9(12). Abstract.  Author URL.
Russell MA, Morgan NG (2014). The impact of anti-inflammatory cytokines on the pancreatic β-cell. Islets, 6(3). Abstract.  Author URL.
Russell MA, Cooper AC, Dhayal S, Morgan NG (2013). Differential effects of interleukin-13 and interleukin-6 on Jak/STAT signaling and cell viability in pancreatic β-cells. Islets, 5(2), 95-105. Abstract.  Author URL.
Richardson SJ, Leete P, Bone AJ, Foulis AK, Morgan NG (2013). Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1. Diabetologia, 56(1), 185-193. Abstract.
Lind K, Richardson SJ, Leete P, Morgan NG, Korsgren O, Flodström-Tullberg M (2013). Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon Treated Primary Human Pancreatic Islets. Journal of virology
Anagandula M, Richardson SJ, Oberste MS, Sioofy-Khojine A-B, Hyöty H, Morgan NG, Korsgren O, Frisk G (2013). Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway. Journal of Medical Virology
Caton PW, Richardson SJ, Kieswich J, Bugliani M, Holland ML, Marchetti P, Morgan NG, Yaqoob MM, Holness MJ, Sugden MC, et al (2013). Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Diabetologia, 1-10.
Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ, Morgan NG, Eizirik DL (2012). Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia, 55(9), 2417-2420. Abstract.
Lundh M, Christensen DP, Damgaard Nielsen M, Richardson SJ, Dahllöf MS, Skovgaard T, Berthelsen J, Dinarello CA, Stevenazzi A, Mascagni P, et al (2012). Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children. Diabetologia, 1-11.
Stone VM, Dhayal S, Smith DM, Lenaghan C, Brocklehurst KJ, Morgan NG (2012). The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. Br J Pharmacol, 165(8), 2758-2770. Abstract.  Author URL.
Keane DC, Takahashi HK, Dhayal S, Morgan NG, Curi R, Newsholme P (2011). Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clin Sci (Lond), 120(5), 195-206. Abstract.  Author URL.
Russell MA, Morgan NG (2011). Conditional expression of the FTO gene product in rat INS-1 cells reveals its rapid turnover and a role in the profile of glucose-induced insulin secretion. Clin Sci (Lond), 120(9), 403-413. Abstract.  Author URL.
Reers C, Hauge-Evans AC, Morgan NG, Willcox A, Persaud SJ, Jones PM (2011). Downregulation of proliferation does not affect the secretory function of transformed β-cell lines regardless of their anatomical configuration. Islets, 3(3), 80-88. Abstract.
Johnstone KA, Diakogiannaki E, Dhayal S, Morgan NG, Harries LW (2011). Dysregulation of Hnf1b gene expression in cultured beta-cells in response to cytotoxic fatty acid. JOP, 12(1), 6-10. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2011). Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes. Diabetologia, 54(9), 2417-2420. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Morgan NG, Foulis AK (2011). Immunopathology of the human pancreas in type-I diabetes. Semin Immunopathol, 33(1), 9-21. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Pharmacological characterization of the cytoprotective effects of polyunsaturated fatty acids in insulin-secreting BRIN-BD11 cells. Br J Pharmacol, 162(6), 1340-1350. Abstract.  Author URL.
Dhayal S, Morgan NG (2011). Structure-activity relationships influencing lipid-induced changes in eIF2α phosphorylation and cell viability in BRIN-BD11 cells. FEBS Lett, 585(14), 2243-2248. Abstract.  Author URL.
Lidder P, Flanagan D, Fleming S, Russell M, Morgan N, Wheatley T, Rahamin J, Shaw S, Lewis S (2010). Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr, 103(11), 1635-1641. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2010). Evidence of increased islet cell proliferation in patients with recent-onset type 1 diabetes. Diabetologia, 53, 2020-2028.
Russell MA, Morgan NG (2010). Expression and functional roles of guanylate cyclase isoforms in BRIN-BD11 β-cells. Islets, 2(6), 374-382. Abstract.  Author URL.
Persaud SJ, Arden C, Bergsten P, Bone AJ, Brown J, Dunmore S, Harrison M, Hauge-Evans A, Kelly C, King A, et al (2010). Pseudoislets as primary islet replacements for research: Report on a symposium at King's College London, London UK. Islets, 2(4), 236-239. Abstract.
Garin I, Edghill EL, Akerman I, Rubio-Cabezas O, Rica I, Locke JM, Maestro MA, Alshaikh A, Bundak R, Del Castillo G, et al (2010). Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 107(7), 3105-3110. Abstract.
Dhayal S, Morgan NG (2010). The significance of GPR119 agonists as a future treatment for type 2 diabetes. Drug News Perspect, 23(7), 418-424. Abstract.  Author URL.
Morgan NG, Dhayal S (2010). Unsaturated fatty acids as cytoprotective agents in the pancreatic beta-cell. Prostaglandins Leukot Essent Fatty Acids, 82(4-6), 231-236. Abstract.  Author URL.
Richardson SJ, Willcox A, Hilton DA, Tauriainen S, Hyoty H, Bone AJ, Foulis AK, Morgan NG (2010). Use of antisera directed against dsRNA to detect viral infections in formalin-fixed paraffin-embedded tissue. J Clin Virol, 49(3), 180-185. Abstract.  Author URL.
Willcox A, Richardson SJ, Bone AJ, Foulis AK, Morgan NG (2009). Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol, 155(2), 173-181. Abstract.  Author URL.
Morgan NG (2009). Fatty acids and beta-cell toxicity. Curr Opin Clin Nutr Metab Care, 12(2), 117-122. Abstract.  Author URL.
Morgan NG, Dhayal S (2009). G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell. Biochem Pharmacol, 78(12), 1419-1427. Abstract.  Author URL.
Kaminski A, Welters HJ, Kaminski ER, Morgan NG (2009). Human and rodent pancreatic beta-cells express IL-4 receptors and IL-4 protects against beta-cell apoptosis by activation of the PI3K and JAK/STAT pathways. Biosci Rep, 30(3), 169-175. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). Islet-associated macrophages in type 2 diabetes. Diabetologia, 52(8), 1686-1688. Author URL.
Morgan NG, Diakogiannaki E, Russell MA (2009). The incubation and monitoring of cell viability in primary rat islets of Langerhans and pancreatic beta-cell lines. Methods Mol Biol, 560, 53-64. Abstract.  Author URL.
Richardson SJ, Willcox A, Bone AJ, Foulis AK, Morgan NG (2009). The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes. Diabetologia, 52(6), 1143-1151. Abstract.  Author URL.
Diakogiannaki E, Welters HJ, Morgan NG (2008). Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol, 197(3), 553-563. Abstract.  Author URL.
Farn RD, Morgan NG, Ramsden CA (2008). Preparation of analogues of efaroxan and KU14R as potential imidazoline receptor subtype 3 ligands. Journal of Heterocyclic Chemistry, 45(3), 887-896. Abstract.
Ravanan R, Wong SF, Morgan NG, Mathieson PW, Smith RM (2007). Inhalation of glutamic acid decarboxylase 65-derived peptides can protect against recurrent autoimmune but not alloimmune responses in the non-obese diabetic mouse. Clin Exp Immunol, 148(2), 368-372. Abstract.  Author URL.
Newsholme P, Keane D, Welters HJ, Morgan NG (2007). Life and death decisions of the pancreatic beta-cell: the role of fatty acids. Clin Sci (Lond), 112(1), 27-42. Abstract.  Author URL.
Diakogiannaki E, Dhayal S, Childs CE, Calder PC, Welters HJ, Morgan NG (2007). Mechanisms involved in the cytotoxic and cytoprotective actions of saturated versus monounsaturated long-chain fatty acids in pancreatic beta-cells. J Endocrinol, 194(2), 283-291. Abstract.  Author URL.
Kaminski A, Kaminski ER, Morgan NG (2007). Pre-incubation with interleukin-4 mediates a direct protective effect against the loss of pancreatic beta-cell viability induced by proinflammatory cytokines. Clin Exp Immunol, 148(3), 583-588. Abstract.  Author URL.
Diakogiannaki E, Welters HJ, Eickelmann P, Morgan NG (2007). The unsaturated fatty acid, palmitoleate, inhibits the expression of the ER-stress-associated pro-apoptotic factor CHOP-10/GADD153 in pancreatic beta-cells. DIABETIC MEDICINE, 24, 10-11. Author URL.
Tarasov AI, Welters HJ, Senkel S, Ryffel GU, Hattersley AT, Morgan NG, Ashcroft FM (2006). A Kir6.2 mutation causing neonatal diabetes impairs electrical activity and insulin secretion from INS-1 beta-cells. Diabetes, 55(11), 3075-3082. Abstract.  Author URL.
Welters HJ, Senkel S, Klein-Hitpass L, Erdmann S, Thomas H, Harries LW, Pearson ER, Bingham C, Hattersley AT, Ryffel GU, et al (2006). Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cells. J Endocrinol, 190(1), 171-181. Abstract.  Author URL.
NMorgan, Diakogiannaki E, Mordue J, Welters H (2006). Differential protective effects of palmitoleic acid and cAMP on caspase activation and cell viability in pancreatic b-cells exposed to pamitate. APOPTOSIS, 11(7), 1231-1238.
Harries LW, Ellard S, Stride A, Morgan NG, Hattersley AT (2006). Isomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes. Hum Mol Genet, 15(14), 2216-2224. Abstract.  Author URL.
Taylor JP, Jackson DA, Morgan NG, Chan SLF (2006). Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process. Biochem Biophys Res Commun, 349(2), 809-815. Abstract.  Author URL.
(2004). 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia, 47(Suppl 1), A1-A464. Author URL.
Welters HJ, Smith SA, Tadayyon M, Scarpello JHB, Morgan NG (2004). Evidence that protein kinase Cdelta is not required for palmitate-induced cytotoxicity in BRIN-BD11 beta-cells. J Mol Endocrinol, 32(1), 227-235. Abstract.  Author URL.
Welters HJ, McBain SC, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Expression and functional activity of PPARgamma in pancreatic beta cells. Br J Pharmacol, 142(7), 1162-1170. Abstract.  Author URL.
Prell GD, Martinelli GP, Holstein GR, Matulić-Adamić J, Watanabe KA, Chan SLF, Morgan NG, Haxhiu MA, Ernsberger P (2004). Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A, 101(37), 13677-13682. Abstract.  Author URL.
Kaminski A, Gao H, Morgan NG (2004). Involvement of the cGMP signalling pathway in the regulation of viability in insulin-secreting BRIN-BD11 cells. FEBS Lett, 559(1-3), 118-124. Abstract.  Author URL.
Welters HJ, Tadayyon M, Scarpello JHB, Smith SA, Morgan NG (2004). Mono-unsaturated fatty acids protect against beta-cell apoptosis induced by saturated fatty acids, serum withdrawal or cytokine exposure. FEBS Lett, 560(1-3), 103-108. Abstract.  Author URL.
Yang Y, Zhang S, Jones G, Morgan N, El Haj AJ (2004). Phosphorylcholine-containing polymers for use in cell encapsulation. Artif Cells Blood Substit Immobil Biotechnol, 32(1), 91-104. Abstract.  Author URL.
Squires PE, Hills CE, Rogers GJ, Garland P, Farley SR, Morgan NG (2004). The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells. Eur J Pharmacol, 501(1-3), 31-39. Abstract.  Author URL.
Cooper EJ, Hudson AL, Parker CA, Morgan NG (2003). Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol, 482(1-3), 189-196. Abstract.  Author URL.
Gao H, Mourtada M, Morgan NG (2003). Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells. JOP, 4(3), 117-124. Abstract.  Author URL.
McBain SC, Morgan NG (2003). Functional effects of expression of wolframin-antisense transcripts in BRIN-BD11 beta-cells. Biochem Biophys Res Commun, 307(3), 684-688. Abstract.  Author URL.
Elliott J, Scarpello JHB, Morgan NG (2002). Differential effects of genistein on apoptosis induced by fluoride and pertussis toxin in human and rat pancreatic islets and RINm5F cells. J Endocrinol, 172(1), 137-143. Abstract.  Author URL.
Kowluru A, Morgan NG (2002). GTP-binding proteins in cell survival and demise: the emerging picture in the pancreatic beta-cell. Biochem Pharmacol, 63(6), 1027-1035. Abstract.  Author URL.
Chan SLF, Monks LK, Gao H, Deaville P, Morgan NG (2002). Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell. Br J Pharmacol, 136(1), 31-36. Abstract.  Author URL.
Chan SL, Mourtada M, Morgan NG (2001). Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan. Diabetes, 50(2), 340-347. Abstract.  Author URL.
Elliott J, Scarpello JH, Morgan NG (2001). Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic beta-cell line, RINm5F. Br J Pharmacol, 132(1), 119-126. Abstract.  Author URL.
Morgan NG, Chan SL (2001). Imidazoline binding sites in the endocrine pancreas: can they fulfil their potential as targets for the development of new insulin secretagogues?. Curr Pharm Des, 7(14), 1413-1431. Abstract.  Author URL.
Trigwell SM, Radford PM, Page SR, Loweth AC, James RF, Morgan NG, Todd I (2001). Islet glutamic acid decarboxylase modified by reactive oxygen species is recognized by antibodies from patients with type 1 diabetes mellitus. Clin Exp Immunol, 126(2), 242-249. Abstract.  Author URL.
Clews J, Morgan NG, Ramsden CA (2001). Preparation of novel 2-(benzo[<i>b</i>]furan-2-yl)-1<i>H</i>-imidazolines for photoaffinity labelling and affinity isolation of imidazoline binding proteins. JOURNAL OF HETEROCYCLIC CHEMISTRY, 38(2), 519-521. Author URL.
Clews J, Morgan NG, Ramsden CA (2001). Preparation of the I<sub>3</sub> imidazoline receptor antagonist KU14R and related 2,3-dihydrobenzo[<i>b</i>]furan derivatives. SYNTHESIS-STUTTGART(10), 1546-1550. Author URL.
Loweth AC, Watts K, McBain SC, Williams GT, Scarpello JH, Morgan NG (2000). Dissociation between Fas expression and induction of apoptosis in human islets of Langerhans. Diabetes Obes Metab, 2(1), 57-60. Abstract.  Author URL.
Mourtada M, Elliott J, Smith SA, Morgan NG (2000). Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells. Naunyn Schmiedebergs Arch Pharmacol, 361(2), 146-154. Abstract.  Author URL.
(1999). 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999. Diabetologia, 42(Suppl 1), A1-A330. Author URL.
Monks LK, Cosgrove KE, Dunne MJ, Ramsden CA, Morgan NG, Chan SL (1999). Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as a ligand. FEBS Lett, 447(1), 61-64. Abstract.  Author URL.
Pizzinat N, Chan SL, Remaury A, Morgan NG, Parini A (1999). Characterization of monoamine oxidase isoforms in human islets of Langerhans. Life Sci, 65(4), 441-448. Abstract.  Author URL.
Pelé-Tounian A, Chan SL, Rondu F, Le Bihan G, Giroix MH, Lamouri A, Touboul E, Pfeiffer B, Manechez D, Renard P, et al (1999). Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats. Eur J Pharmacol, 377(1), 81-87. Abstract.  Author URL.
Parker CA, Hudson AL, Nutt DJ, Dillon MP, Eglen RM, Chan SL, Morgan NG, Crosby J (1999). Extraction of active clonidine-displacing substance from bovine lung and comparison with clonidine-displacing substance extracted from other tissues. Eur J Pharmacol, 378(2), 213-221. Abstract.  Author URL.
Morgan NG (1999). Imidazoline receptors: new targets for antihyperglycaemic drugs. Expert Opin Investig Drugs, 8(5), 575-584. Abstract.  Author URL.
Mourtada M, Chan SL, Smith SA, Morgan NG (1999). Multiple effector pathways regulate the insulin secretory response to the imidazoline RX871024 in isolated rat pancreatic islets. Br J Pharmacol, 127(5), 1279-1287. Abstract.  Author URL.
Eglen RM, Hudson AL, Kendall DA, Nutt DJ, Morgan NG, Wilson VG, Dillon MP (1998). 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. Trends Pharmacol Sci, 19(9), 381-390. Abstract.  Author URL.
El-Mansoury AM, Morgan NG (1998). Activation of protein kinase C modulates alpha2-adrenergic signalling in rat pancreatic islets. Cell Signal, 10(9), 637-643. Abstract.  Author URL.
Chan SL, Pallett AL, Clews J, Ramsden CA, Chapman JC, Kane C, Dunne MJ, Morgan NG (1998). Characterisation of new efaroxan derivatives for use in purification of imidazoline-binding sites. Eur J Pharmacol, 355(1), 67-76. Abstract.  Author URL.
Mourtada M, Smith SA, Morgan NG (1998). Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans. Eur J Pharmacol, 350(2-3), 251-258. Abstract.  Author URL.
Loweth AC, Williams GT, James RF, Scarpello JH, Morgan NG (1998). Human islets of Langerhans express Fas ligand and undergo apoptosis in response to interleukin-1beta and Fas ligation. Diabetes, 47(5), 727-732. Abstract.  Author URL.
Loweth AC, Morgan NG (1998). Methods for the study of NO-induced apoptosis in cultured cells. Methods Mol Biol, 100, 311-320. Author URL.
Chan SL, Morgan NG (1998). Sigma receptor ligands and imidazoline secretagogues mediate their insulin secretory effects by activating distinct receptor systems in isolated islets. Eur J Pharmacol, 350(2-3), 267-272. Abstract.  Author URL.
Chan SL, Pallett AL, Morgan NG (1997). Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch Pharmacol, 356(6), 763-768. Abstract.  Author URL.
Chan SL, Perrett CW, Morgan NG (1997). Differential expression of alpha 2-adrenoceptor subtypes in purified rat pancreatic islet A- and B-cells. Cell Signal, 9(1), 71-78. Abstract.  Author URL.
Loweth AC, Williams GT, Scarpello JH, Morgan NG (1997). Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15. FEBS Lett, 400(3), 285-288. Abstract.  Author URL.
Chan SL, Pallett AL, Clews J, Ramsden CA, Morgan NG (1997). Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with sigma receptors. Eur J Pharmacol, 323(2-3), 241-244. Abstract.  Author URL.
Mourtada M, Smith SA, Morgan NG (1997). Insulin secretagogues with an imidazoline structure inhibit arginine-induced secretion from isolated glucagon secretion from isolated rat islets of Langerhans. Biochem Biophys Res Commun, 236(1), 162-166. Abstract.  Author URL.
Mourtada M, Brown CA, Smith SA, Piercy V, Chan SL, Morgan NG (1997). Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion. Br J Pharmacol, 121(4), 799-805. Abstract.  Author URL.
Di Matteo MA, Loweth AC, Thomas S, Mabley JG, Morgan NG, Thorpe JR, Green IC (1997). Superoxide, nitric oxide, peroxynitrite and cytokine combinations all cause functional impairment and morphological changes in rat islets of Langerhans and insulin secreting cell lines, but dictate cell death by different mechanisms. Apoptosis, 2(2), 164-177. Abstract.  Author URL.
Chan SL, Atlas D, James RF, Morgan NG (1997). The effect of the putative endogenous imidazoline receptor ligand, clonidine-displacing substance, on insulin secretion from rat and human islets of Langerhans. Br J Pharmacol, 120(5), 926-932. Abstract.  Author URL.
Loweth AC, Scarpello JH, Morgan NG (1996). A specific inhibitor of cytosolic phospholipase A2 activity, AACOCF3, inhibits glucose-induced insulin secretion from isolated rat islets. Biochem Biophys Res Commun, 218(2), 423-427. Abstract.  Author URL.
Lacey RJ, Chan SL, Cable HC, James RF, Perrett CW, Scarpello JH, Morgan NG (1996). Expression of alpha 2- and beta-adrenoceptor subtypes in human islets of Langerhans. J Endocrinol, 148(3), 531-543. Abstract.  Author URL.
Loweth AC, Williams GT, Scarpello JH, Morgan NG (1996). Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic beta-cells. Exp Cell Res, 229(1), 69-76. Abstract.  Author URL.
Morgan NG, Pallett AL, Mourtada M, Chan SLF, Clews J, Ramsden CA (1996). Synthesis and characterisation of KU14R a novel antagonist of the pancreatic islet imidazoline binding site. DIABETOLOGIA, 39, 456-456. Author URL.
Cable HC, el-Mansoury A, Morgan NG (1995). Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells. Biochem J, 307 ( Pt 1)(Pt 1), 169-174. Abstract.  Author URL.
Morgan NG, Chan SL, Brown CA, Tsoli E (1995). Characterization of the imidazoline binding site involved in regulation of insulin secretion. Ann N Y Acad Sci, 763, 361-373. Author URL.
Chan SL, Brown CA, Scarpello KE, Morgan NG (1995). Pancreatic beta-cells express an imidazoline binding site that is distinct from I1 and I2 sites. Ann N Y Acad Sci, 763, 153-156. Author URL.
Loweth AC, Scarpello JH, Morgan NG (1995). Phospholipase A2 expression in human and rodent insulin-secreting cells. Mol Cell Endocrinol, 112(2), 177-183. Abstract.  Author URL.
Tsoli E, Chan SL, Morgan NG (1995). The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans. Eur J Pharmacol, 284(1-2), 199-203. Abstract.  Author URL.
Loweth AC, Scarpello JH, Morgan NG (1994). A comparison of cytosolic phospholipase A2 expression in human islets of Langerhans and rodent insulin-secreting cells. Biochem Soc Trans, 22(4). Author URL.
Chan SL, Brown CA, Scarpello KE, Morgan NG (1994). The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites. Br J Pharmacol, 112(4), 1065-1070. Abstract.  Author URL.
Morgan NG, Cable HC, Newcombe NR, Williams GT (1994). Treatment of cultured pancreatic B-cells with streptozotocin induces cell death by apoptosis. Biosci Rep, 14(5), 243-250. Abstract.  Author URL.
Brown CA, Chan SL, Stillings MR, Smith SA, Morgan NG (1993). Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080. Br J Pharmacol, 110(3), 1017-1022. Abstract.  Author URL.
Lacey RJ, Cable HC, James RF, London NJ, Scarpello JH, Morgan NG (1993). Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans. J Endocrinol, 138(3), 555-563. Abstract.  Author URL.
Brown CA, Morgan NG (1993). Control of insulin secretion by imidazolines in rat pancreatic islets. Biochem Soc Trans, 21(2). Author URL.
Brown CA, Loweth AC, Smith SA, Morgan NG (1993). Stimulation of insulin secretion by imidazoline compounds is not due to interaction with non-adrenoceptor idazoxan binding sites. Br J Pharmacol, 108(2), 312-317. Abstract.  Author URL.
Chan SL, Brown CA, Morgan NG (1993). Stimulation of insulin secretion by the imidazoline alpha 2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site. Eur J Pharmacol, 230(3), 375-378. Abstract.  Author URL.
Lacey RJ, Scarpello JH, Morgan NG (1992). Evidence that the presence of arginine can lead to overestimation of glucagon levels measured by radioimmunoassay. Clin Chim Acta, 210(3), 211-219. Author URL.
Berrow NS, Milligan G, Morgan NG (1992). Immunological characterization of the guanine-nucleotide binding proteins Gi and Go in rat islets of Langerhans. J Mol Endocrinol, 8(2), 103-108. Abstract.  Author URL.
Berrow NS, Hurst RD, Chan SL, Morgan NG (1992). Immunoprecipitation of a pertussis toxin substrate of the G(o) family from rat islets of Langerhans. Biosci Rep, 12(2), 95-100. Abstract.  Author URL.
Chan SL, Stillings MR, Morgan NG (1991). Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128. Biochem Biophys Res Commun, 176(3), 1545-1551. Abstract.  Author URL.
Lacey RJ, Berrow NS, Scarpello JH, Morgan NG (1991). Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat. Br J Pharmacol, 103(3), 1824-1828. Abstract.  Author URL.
Chan SL, Dunne MJ, Stillings MR, Morgan NG (1991). The alpha 2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells. Eur J Pharmacol, 204(1), 41-48. Abstract.  Author URL.
Lacey RJ, Berrow NS, London NJ, Lake SP, James RF, Scarpello JH, Morgan NG (1990). Differential effects of beta-adrenergic agonists on insulin secretion from pancreatic islets isolated from rat and man. J Mol Endocrinol, 5(1), 49-54. Abstract.  Author URL.
Hurst RD, Morgan NG (1990). Evidence for differential effects of noradrenaline and somatostatin on intracellular messenger systems in rat islets of Langerhans. J Mol Endocrinol, 4(3), 231-237. Abstract.  Author URL.
Berrow NS, Morgan NG (1990). Evidence for the presence of low molecular mass GTP-binding proteins in rat islets of Langerhans. Biochem Soc Trans, 18(3), 485-486. Author URL.
Chan SL, Morgan NG (1990). Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels. Eur J Pharmacol, 176(1), 97-101. Abstract.  Author URL.
Morgan NG, Hurst RD, Berrow NS, Montague W (1989). Calcium handling by stimulated islets of Langerhans. Biochem Soc Trans, 17(1), 64-66. Author URL.
Hurst RD, Chan SL, Morgan NG (1989). Effects of benextramine on the adrenergic inhibition of insulin secretion in isolated rat pancreatic islets. J Mol Endocrinol, 2(2), 99-105. Abstract.  Author URL.
Chan SL, Morgan NG (1989). Effects of phenoxybenzamine on insulin secretion from isolated rat islets of Langerhans. Biosci Rep, 9(2), 223-230. Abstract.  Author URL.
Hurst RD, Morgan NG (1989). Intracellular events responsible for the inhibition of insulin secretion by somatostatin. Biochem Soc Trans, 17(6), 1085-1086. Author URL.
Morgan NG, Hurst RD (1988). Dissociation between intracellular calcium mobilization and insulin secretion in isolated rat islets of Langerhans. FEBS Lett, 227(2), 153-156. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1987). Mechanisms involved in intracellular calcium mobilization in isolated rat islets of Langerhans. Biochem J, 244(3), 669-674. Abstract.  Author URL.
Montague W, Morgan NG, Rumford GM, Prince CA (1985). Effect of glucose on polyphosphoinositide metabolism in isolated rat islets of Langerhans. Biochem J, 227(2), 483-489. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Effects of noradrenaline on 45Ca2+ efflux from isolated rat islets of Langerhans. Biosci Rep, 5(12), 1053-1060. Abstract.  Author URL.
Morgan NG, Short CD, Rumford GM, Montague W (1985). Effects of the calcium-channel agonist CGP 28392 on insulin secretion from isolated rat islets of Langerhans. Biochem J, 231(3), 629-634. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Studies on the mechanism by which melittin stimulates insulin secretion from isolated rat islets of Langerhans. Biochim Biophys Acta, 845(3), 526-532. Abstract.  Author URL.
Morgan NG, Montague W (1985). Studies on the mechanism of inhibition of glucose-stimulated insulin secretion by noradrenaline in rat islets of Langerhans. Biochem J, 226(2), 571-576. Abstract.  Author URL.
Morgan NG, Rumford GM, Montague W (1985). Studies on the role of inositol trisphosphate in the regulation of insulin secretion from isolated rat islets of Langerhans. Biochem J, 228(3), 713-718. Abstract.  Author URL.
Morgan NG, Charest R, Blackmore PF, Exton JH (1984). Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism. Proc Natl Acad Sci U S A, 81(13), 4208-4212. Abstract.  Author URL.
Morgan NG, Montague W (1984). Stimulation of insulin secretion from isolated rat islets of Langerhans by melittin. Biosci Rep, 4(8), 665-671. Abstract.  Author URL.
Morgan NG, Blackmore PF, Exton JH (1983). Age-related changes in the control of hepatic cyclic AMP levels by alpha 1- and beta 2-adrenergic receptors in male rats. J Biol Chem, 258(8), 5103-5109. Abstract.  Author URL.
Morgan NG, Exton JH, Blackmore PF (1983). Angiotensin II inhibits hepatic cAMP accumulation induced by glucagon and epinephrine and their metabolic effects. FEBS Lett, 153(1), 77-80. Abstract.  Author URL.
Morgan NG, Waynick LE, Exton JH (1983). Characterisation of the alpha 1-adrenergic control of hepatic cAMP in male rats. Eur J Pharmacol, 96(1-2), 1-10. Abstract.  Author URL.
Morgan NG, Blackmore PF, Exton JH (1983). Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP. J Biol Chem, 258(8), 5110-5116. Abstract.  Author URL.
Morgan NG, Shipp CC, Exton JH (1983). Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin. FEBS Lett, 163(2), 277-281. Abstract.  Author URL.
Morgan NG, Shuman EA, Exton JH, Blackmore PF (1982). Stimulation of hepatic glycogenolysis by alpha 1- and beta 2-adrenergic agonists. Evidence against short term agonist-induced desensitization of the responses. J Biol Chem, 257(23), 13907-13910. Abstract.  Author URL.
Morgan NG, Montague W (1982). Studies on the interaction of staphylococcal delta-haemolysin with isolated islets of Langerhans. Biochem J, 204(1), 111-125. Abstract.  Author URL.
Morgan NG, Fitzhugh AJ, Montague W (1981). The effect of staphylococcal delta-haemolysin on the secretory activity of the pancreatic beta-cell. Biosci Rep, 1(2), 135-140. Abstract.  Author URL.
Ducommun Y, Morgan NG, Montague W (1979). Subcellular distribution of protein kinase activities in mammalian islets of Langerhans [proceedings]. Biochem Soc Trans, 7(5), 913-915. Author URL.

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External Engagement and Impact

Committee/panel activities

Diabetes UK Research Committee.

International Member, Ministry of Higher Education and Science Pharmacology Committee,
Danish Agency for Higher Education and Science.

Consortium member: INNODIA & INNODIA-HARVEST - Horizonn 2020 prgrammes of the EU.

Approved Investigator, JDRF Network of Pancreaic Organ Donors (nPOD); USA.

Editorial responsibilities

Invited lectures

Media Coverage

Interviews on:
BBC News; Sky News; BBC Radio 5 live; BBC Local Radio (Devon & Cornwall); BBC Radio Wales, Times Radio, BBC Radio 4.

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  • Plenary lecturer; Academic tutor, Special Study Unit Convenor.
  • Director of Postgraduate Research; Chair of Research Degrees Committee.

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Supervision / Group

Postdoctoral researchers

  • Pia Leete
  • Mark Russell

Postgraduate researchers

  • Kaiyven Afi Leslie
  • Pouria Akhbari
  • Mohammad Baity
  • Jessica Chaffey
  • Shalinee Dhayal
  • Christine Flaxman
  • Jessica Hill
  • Pia Leete
  • Katie Partridge
  • Mark Russell

Research Technicians

  • Christine Flaxman

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