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Dr. Nicholas Clifton

Dr. Nicholas Clifton

Senior Research Fellow

 RILD Building 

 

University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK

Overview

Dr Nicholas Clifton is a Senior Research Fellow at the University of Exeter Medical School funded by a Career Development Award from the Medical Research Council. He leads research focused on patterns of gene expression and their association with psychiatric disorders. He uses tissue- or cell-specific RNA sequencing and ribosomal profiling to track expression dynamics across development and apply these data to questions about genetic risk through bioinformatics.

Dr Clifton has a background in Neuroscience, which he studied at the University of Nottingham before undertaking a Wellcome Trust Integrative Neuroscience PhD in the Neuroscience & Mental Health Research Institute at Cardiff University. He went on to take up an Early-Career Research Fellowship and a Research Fellowship at Cardiff before acquiring his Career Development Award.

Qualifications

  • Associate Fellow of the Higher Education Academy
  • PhD Integrative Neuroscience, Cardiff University
  • MSci Hons Neuroscience, University of Nottingham

Research

Research interests

Dr Clifton studies how genetic risk factors for psychiatric disorders such as schizophrenia influence biological systems in the brain as it develops. The goal of his current research is to understand when and where locally translated synaptic genes contribute to susceptibility to schizophrenia.

Publications

Key publications | Publications by category | Publications by year

Publications by category


Journal articles

Clifton NE, Bosworth ML, Haan N, Rees E, Holmans PA, Wilkinson LS, Isles AR, Collins MO, Hall J (2022). Developmental disruption to the cortical transcriptome and synaptosome in a model of <i>SETD1A</i> loss-of-function. Human Molecular Genetics Abstract.  Full text.
Clifton NE, Collado-Torres L, Burke EE, Pardinas AF, Harwood JC, Di Florio A, Walters JTR, Owen MJ, O'Donovan MC, Weinberger DR, et al (2021). Developmental Profile of Psychiatric Risk Associated with Voltage-Gated Cation Channel Activity. BIOLOGICAL PSYCHIATRY, 90(6), 399-408. Author URL.
Clifton NE, Rees E, Holmans PA, Pardiñas AF, Harwood JC, Di Florio A, Kirov G, Walters JTR, O’Donovan MC, Owen MJ, et al (2021). Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry, 26(7), 2977-2990. Abstract.
Notter T, Schalbetter SM, Clifton NE, Mattei D, Richetto J, Thomas K, Meyer U, Hall J (2021). Neuronal activity increases translocator protein (TSPO) levels. MOLECULAR PSYCHIATRY, 26(6), 2025-2037. Author URL.
Clifton NE, Thomas KL, Wilkinson LS, Hall J, Trent S (2020). FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability. Complex Psychiatry, 6(1-2), 5-19.
Morgan SE, Seidlitz J, Whitaker KJ, Romero-Garcia R, Clifton NE, Scarpazza C, van Amelsvoort T, Marcelis M, van Os J, Donohoe G, et al (2019). Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes. Proc Natl Acad Sci U S A, 116(19), 9604-9609. Abstract.  Author URL.
Clifton NE, Hannon E, Harwood JC, Di Florio A, Thomas KL, Holmans PA, Walters JTR, O’Donovan MC, Owen MJ, Pocklington AJ, et al (2019). Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry, 9(1). Abstract.
Clifton NE, Trent S, Thomas KL, Hall J (2019). Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity. Complex Psychiatry, 5(3), 147-161. Abstract.
Sykes L, Clifton NE, Hall J, Thomas KL (2018). Regulation of the Expression of the Psychiatric Risk Gene &lt;b&gt;&lt;i&gt;Cacna1c&lt;/i&gt;&lt;/b&gt; during Associative Learning. Complex Psychiatry, 4(3), 149-157. Abstract.
Clifton NE, Thomas KL, Hall J (2018). The effect of ketamine on the consolidation and extinction of contextual fear memory. JOURNAL OF PSYCHOPHARMACOLOGY, 32(2), 156-162. Author URL.
Clifton NE, Cameron D, Trent S, Sykes LH, Thomas KL, Hall J (2017). Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning. NEURAL PLASTICITY, 2017 Author URL.
Clifton NE, Pocklington AJ, Scholz B, Rees E, Walters JTR, Kirov G, O'Donovan MC, Owen MJ, Wilkinson LS, Thomas KL, et al (2017). Schizophrenia copy number variants and associative learning. Molecular Psychiatry, 22(2), 178-182. Abstract.
Clifton NE, Morisot N, Girardon S, Millan MJ, Loiseau F (2013). Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine. PSYCHOPHARMACOLOGY, 225(3), 579-594. Author URL.

Publications by year


In Press

Clifton NE, Collado-Torres L, Burke EE, Pardiñas AF, Harwood JC, Di Florio A, Walters JTR, Owen MJ, O’Donovan MC, Weinberger DR, et al (In Press). Developmental profile of psychiatric risk associated with voltage-gated cation channel activity.  Abstract.
Clifton NE, Rees E, Holmans PA, Pardiñas AF, Harwood JC, Di Florio A, Kirov G, Walters JTR, O’Donovan MC, Owen MJ, et al (In Press). Genetic association of FMRP targets with psychiatric disorders.  Abstract.

2022

Clifton NE, Bosworth ML, Haan N, Rees E, Holmans PA, Wilkinson LS, Isles AR, Collins MO, Hall J (2022). Developmental disruption to the cortical transcriptome and synaptosome in a model of <i>SETD1A</i> loss-of-function. Human Molecular Genetics Abstract.  Full text.

2021

Clifton NE, Collado-Torres L, Burke EE, Pardinas AF, Harwood JC, Di Florio A, Walters JTR, Owen MJ, O'Donovan MC, Weinberger DR, et al (2021). Developmental Profile of Psychiatric Risk Associated with Voltage-Gated Cation Channel Activity. BIOLOGICAL PSYCHIATRY, 90(6), 399-408. Author URL.
Clifton NE, Rees E, Holmans PA, Pardiñas AF, Harwood JC, Di Florio A, Kirov G, Walters JTR, O’Donovan MC, Owen MJ, et al (2021). Genetic association of FMRP targets with psychiatric disorders. Molecular Psychiatry, 26(7), 2977-2990. Abstract.
Notter T, Schalbetter SM, Clifton NE, Mattei D, Richetto J, Thomas K, Meyer U, Hall J (2021). Neuronal activity increases translocator protein (TSPO) levels. MOLECULAR PSYCHIATRY, 26(6), 2025-2037. Author URL.

2020

Clifton NE, Thomas KL, Wilkinson LS, Hall J, Trent S (2020). FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability. Complex Psychiatry, 6(1-2), 5-19.

2019

Morgan SE, Seidlitz J, Whitaker KJ, Romero-Garcia R, Clifton NE, Scarpazza C, van Amelsvoort T, Marcelis M, van Os J, Donohoe G, et al (2019). Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes. Proc Natl Acad Sci U S A, 116(19), 9604-9609. Abstract.  Author URL.
Clifton NE, Hannon E, Harwood JC, Di Florio A, Thomas KL, Holmans PA, Walters JTR, O’Donovan MC, Owen MJ, Pocklington AJ, et al (2019). Dynamic expression of genes associated with schizophrenia and bipolar disorder across development. Translational Psychiatry, 9(1). Abstract.
Clifton NE, Trent S, Thomas KL, Hall J (2019). Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity. Complex Psychiatry, 5(3), 147-161. Abstract.

2018

Morgan SE, Seidlitz J, Whitaker K, Romero-Garcia R, Clifton NE, Scarpazza C, van Amelsvoort T, Marcelis M, van Os J, Donohoe G, et al (2018). Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes.
Clifton NE, Hannon E, Di Florio A, Thomas KL, Holmans PA, Walters JT, O’Donovan MC, Owen MJ, Pocklington AJ, Hall J, et al (2018). Dynamic expression of risk genes for schizophrenia and bipolar disorder across development.
Sykes L, Clifton NE, Hall J, Thomas KL (2018). Regulation of the Expression of the Psychiatric Risk Gene &lt;b&gt;&lt;i&gt;Cacna1c&lt;/i&gt;&lt;/b&gt; during Associative Learning. Complex Psychiatry, 4(3), 149-157. Abstract.
Clifton NE, Thomas KL, Hall J (2018). The effect of ketamine on the consolidation and extinction of contextual fear memory. JOURNAL OF PSYCHOPHARMACOLOGY, 32(2), 156-162. Author URL.

2017

Clifton NE, Cameron D, Trent S, Sykes LH, Thomas KL, Hall J (2017). Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning. NEURAL PLASTICITY, 2017 Author URL.
Clifton NE, Pocklington AJ, Scholz B, Rees E, Walters JTR, Kirov G, O'Donovan MC, Owen MJ, Wilkinson LS, Thomas KL, et al (2017). Schizophrenia copy number variants and associative learning. Molecular Psychiatry, 22(2), 178-182. Abstract.

2013

Clifton NE, Morisot N, Girardon S, Millan MJ, Loiseau F (2013). Enhancement of social novelty discrimination by positive allosteric modulators at metabotropic glutamate 5 receptors: adolescent administration prevents adult-onset deficits induced by neonatal treatment with phencyclidine. PSYCHOPHARMACOLOGY, 225(3), 579-594. Author URL.

Nick_Clifton Details from cache as at 2022-07-01 21:24:08

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