RILD Building IBD Pharmacogenetics,3rd floor
University of Exeter Medical School, RILD Building, RD&E Hospital Wonford, Barrack Road, Exeter, EX2 5DW, UK
Neil is a PhD researcher working with Dr. Mike Weedon and Dr. Tariq Ahmad in the IBD Pharmacogenetics and bioinformatics department. He has been working as a paediatric doctor for the past three years and developed an interest in inflammatory bowel disease (IBD).
He graduated from medicine in 2013 from the University of Birmingham and did a one-year intercalated degree in Biomedical Healthcare and Ethics at the University of Leeds in 2009. He is near completion of his part-time MSc in Epidemiology (distance) from the London School of Hygiene and Tropical Medicine which will hopefully put him in good steed for the next three years.
Having spent the last five years in North and East London, Neil is excited for his move down to the south-west and hopefully has some more time for climbing and cycling.
My PhD, funded by the charity Crohn’s and Colitis UK and the University of Exeter, aims to understand the response of patients with IBD to anti-TNF therapy, such as infliximab and adalimumab.
Immunogenicity to anti-TNF therapy is a major cause of loss of response, treatment discontinuation, and hypersensitivity reactions and currently cannot be predicted prior to treatment. We aim to develop a stratified approach to the prediction and prevention of immunogenicity that will benefit patients by delivering more durable, safe and cost-effective anti-TNF therapy. To achieve this we aim to:
- Explore analytical aspects of anti-drug antibody measurement for which there is current uncertainty.
- Investigate patient- and treatment-specific factors that predict an individual's risk of developing immunogenicity.
- Refine existing and explore novel strategies to mitigate this risk.
We will employ the latest multi-omic technologies and statistical approaches to identify predictive factors and mechanisms of immunogenicity using clinical data and samples from the Personalised Anti-TNF Therapy in Crohn’s Disease (PANTs) biorepository. The output of this work will be a simple predictive clinical decision tool to be used before starting anti-TNF therapy to minimise the impact of immunogenicity.
I have a longstanding interest in critical appraisal and regularly teach students and doctors about quantitative and qualitative research methods, though my personal research is largely quantitative-based.
External Engagement and Impact
Associate Editor (research and reviews) – Canadian Medical Association Journal