Loading content
Dr Mick Craig

Dr Mick Craig

Senior Research Fellow

7415

Hatherly Neurobiology

Dr Mick Craig is a neurophysiologist interested in how interneurons can control synchronous neuronal network activity, and how different brain regions coordinate their activity across long distances. While comprising only a small percentage of cortical neurons, inhibitory interneurons play a fundamental role in coordinating and pacing the rhythm of neuronal oscillations. Mick's previous work has included studying slow oscillations in sensory and entorhinal cortices, and faster rhythms (gamma oscillations and sharp-wave ripples) in the hippocampus.

The research in Mick's group uses a combination of behavioural, in vivo and in vitro electrophysiological and optogenetic methods to understand the cellular circuitry through which different brain regions communicate across long distances. They are also interested in studying how these long-range projections are disrupted in psychiatric and neurodegenerative disorders.

Want to join us!? We currently have 3 PhD projects being advertised:

  • EPSRC-funded project to use computational neuroscience to study network activity in the brain, with James Rankin as lead supervisor. Click here for more info.
  • BBSRC-funded project to use genetic tools, electrophysiology, optogenetics & behaviour to study pyramidal cell subtypes in the subiculum. Click here for more info.
  • MRC-funded project to use optogenetics, electrophysiology and behaviour to study inputs to the retrosplenial cortex in early Alzheimer's disease. Click here for more info.

Qualifications

2006 MSci (hons), University of Glasgow
2011 DPhil, University of Oxford

Career

Dr Mick Craig completed his undergraduate degree in Neuroscience at the University of Glasgow in 2006. This degree included a year in the pharmaceutical industry, where he carried out schizophrenia research at Merck, Sharp and Dohme in Harlow, Essex. He then moved to the University of Oxford to study on a four year Wellcome Trust DPhil in the OXION programme, working with Prof Ole Paulsen and Dr Louise Upton, graduating in 2011.

In the final year of Mick's doctoral studies, Prof Paulsen moved to the University of Cambridge to take up the Chair of Physiology, so once Mick completed his DPhil, he spent a few months in Cambridge before moving to the National Institutes of Health (Bethesda, USA) in 2011, to work as a Postdoctoral Visiting Fellow in the group of Dr Chris McBain.

Mick moved back to the UK in early 2016 to establish his research group at the University of Exeter on a Research Fellowship funded by the Vandervell Foundation.

Research

Research interests

My research group aims to determine how long-range connections allow different regions of the brain to synchronise their activity, with a particular focus on interactions between various nuclei making up the Papez circuit (such as the prefrontal cortex, entorhinal cortex, hippocampus and subiculum). We are also interested in understanding how inhibitory interneurons can control rhythmic network activity: although interneurons make up only a minority of cortical neurons, they play a fundamental role in coordinating and pacing the activity of principal cells. We approach these questions by using a combination of behavioural, electrophysiological (in vitro and in vivo), optogenetic and viral tracing techniques.

Our principle aim is to discover the laminar and cellular specificity of long-range connections between different circuits, as this knowledge is essential if we are to learn why different conditions, such as dementia or schizophrenia, can affect the same circuits in the brain but have remarkably different symptoms. As well as studying the connectivity within the Papez circuit in healthy conditions, we are also carrying out a number of projects using animal models of Alzheimer's disease, as well as rare genetic variants (CNVs) that increase an individual's susceptibly to psychiatric illness.

If you are interested in neural circuits and want to join our rapidly growing team of neurophysiologists in Exeter, please get in touch. 

Research Team
Dr Lilya Andrianova, Postdoctoral Research Associate (BBSRC)
Erica Brady, PhD student (MRC)
Darren Walsh, Postdoctoral Research Associate (UEMS)

 

Research grants

  • 2017 Medical Research Council
    Title: Circuit mechanisms of disrupted neuronal network function in Alzheimer’s disease. GW4 DTP PhD Studentship to Erica Brady. Role: Lead supervisor
  • 2017 Alzheimer Research UK
    Title: Functional consequences of impaired gamma frequency oscillations in mouse models of dementia. Role: Co-I. (PI: Dr Jon Brown)
  • 2017 Alzheimer Research UK
    Title: Improving Neurotransmission through the Brain’s Memory Centres: A Pharmacogenetic Approach to Treating Dementia. Role: PI
  • 2017 Royal Society
    Partnering Award with South Dartmoor Community College (Role: Academic Lead; School lead: Mr Stephen McGeever)
  • 2016 BBSRC
    Title: Investigating the role of the thalamic nucleus reuniens in relaying prefrontal cortex input to the hippocampus. Role: PI
  • 2016 Alzheimer Research UK
    Title: Contribution to the purchase of a Ti-Sapphire laser to enable establishment of multiphoton fluorescence imaging facility. Role: Co-I (PI: Prof Andy Randall)
  • 2016 Wellcome Trust
    Title: A multiphoton imaging facility for in vitro and in vivo studies of CNS function and disease. Role: Co-I. (PI: Prof Andy Randall)

Key publications | Publications by category | Publications by year

Key publications


Xiao M, Xu D, Craig MT, Pelkey KA, Chien C, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, et al (2017). NPTX2 and cognitive dysfunction in Alzheimer’s Disease. eLife, 6 Abstract.  Author URL.  Full text.
Craig MT, McBain CJ (2015). Fast gamma oscillations are generated intrinsically in CA1 without the involvement of fast-spiking basket cells. Journal of Neuroscience, 35(8), 3616-3624. Abstract.  Full text.
Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, et al (2015). Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Neuron, 85(6), 1257-1272. Abstract.  Full text.
Craig MT, Mayne EW, Bettler B, Paulsen O, Mcbain CJ (2013). Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity. Journal of Physiology, 591(4), 835-843. Abstract.  Full text.
Chittajallu R, Craig MT, Mcfarland A, Yuan X, Gerfen S, Tricoire L, Erkkila B, Barron SC, Lopez CM, Liang BJ, et al (2013). Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT<inf>3A</inf>R expression. Nature Neuroscience, 16(11), 1598-1607. Abstract.  Full text.

Publications by category


Journal articles

Chittajallu R, Wester JC, Craig MT, Barksdale E, Yuan XQ, Akgül G, Fang C, Collins D, Hunt S, Pelkey KA, et al (In Press). Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells. Nat Commun, 8(1). Abstract.  Author URL.  Full text.
Pelkey KA, Chittajallu R, Craig MT, Tricoire L, Wester JC, McBain CJ (2017). Hippocampal GABAergic Inhibitory Interneurons. Physiol Rev, 97(4), 1619-1747. Abstract.  Author URL.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang Y-X, Craig MT, Dong L, Petralia RS, McBain CJ, et al (2017). Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development. Neuron
Xiao M, Xu D, Craig MT, Pelkey KA, Chien C, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, et al (2017). NPTX2 and cognitive dysfunction in Alzheimer’s Disease. eLife, 6 Abstract.  Author URL.  Full text.
Craig MT, McBain CJ (2015). Fast gamma oscillations are generated intrinsically in CA1 without the involvement of fast-spiking basket cells. Journal of Neuroscience, 35(8), 3616-3624. Abstract.  Full text.
Craig MT, McBain CJ (2015). Navigating the circuitry of the brain's GPS system: Future challenges for neurophysiologists. Hippocampus, 25(6), 736-743. Author URL.
Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, et al (2015). Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Neuron, 85(6), 1257-1272. Abstract.  Full text.
Craig MT, McBain CJ (2014). The emerging role of GABA<inf>B</inf> receptors as regulators of network dynamics: Fast actions from a 'slow' receptor?. Current Opinion in Neurobiology, 26, 15-21. Abstract.
Matta JA, Pelkey KA, Craig MT, Chittajallu R, Jeffries BW, McBain CJ (2013). Developmental origin dictates interneuron AMPA and NMDA receptor subunit composition and plasticity. Nat Neurosci, 16(8), 1032-1041. Abstract.  Author URL.
Craig MT, Mayne EW, Bettler B, Paulsen O, Mcbain CJ (2013). Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity. Journal of Physiology, 591(4), 835-843. Abstract.  Full text.
Mayne EW, Craig MT, Mcbain CJ, Paulsen O (2013). Dopamine suppresses persistent network activity via D1-like dopamine receptors in rat medial entorhinal cortex. European Journal of Neuroscience, 37(8), 1242-1247. Abstract.  Full text.
Chittajallu R, Craig MT, Mcfarland A, Yuan X, Gerfen S, Tricoire L, Erkkila B, Barron SC, Lopez CM, Liang BJ, et al (2013). Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT<inf>3A</inf>R expression. Nature Neuroscience, 16(11), 1598-1607. Abstract.  Full text.
Rodríguez-Moreno A, González-Rueda A, Banerjee A, Upton AL, Craig MT, Paulsen O (2013). Presynaptic Self-Depression at Developing Neocortical Synapses. Neuron, 77(1), 35-42. Abstract.

Publications by year


In Press

Chittajallu R, Wester JC, Craig MT, Barksdale E, Yuan XQ, Akgül G, Fang C, Collins D, Hunt S, Pelkey KA, et al (In Press). Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells. Nat Commun, 8(1). Abstract.  Author URL.  Full text.

2017

Pelkey KA, Chittajallu R, Craig MT, Tricoire L, Wester JC, McBain CJ (2017). Hippocampal GABAergic Inhibitory Interneurons. Physiol Rev, 97(4), 1619-1747. Abstract.  Author URL.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang Y-X, Craig MT, Dong L, Petralia RS, McBain CJ, et al (2017). Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development. Neuron
Xiao M, Xu D, Craig MT, Pelkey KA, Chien C, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, et al (2017). NPTX2 and cognitive dysfunction in Alzheimer’s Disease. eLife, 6 Abstract.  Author URL.  Full text.

2015

Craig MT, McBain CJ (2015). Fast gamma oscillations are generated intrinsically in CA1 without the involvement of fast-spiking basket cells. Journal of Neuroscience, 35(8), 3616-3624. Abstract.  Full text.
Craig MT, McBain CJ (2015). Navigating the circuitry of the brain's GPS system: Future challenges for neurophysiologists. Hippocampus, 25(6), 736-743. Author URL.
Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, et al (2015). Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. Neuron, 85(6), 1257-1272. Abstract.  Full text.

2014

Craig MT, McBain CJ (2014). The emerging role of GABA<inf>B</inf> receptors as regulators of network dynamics: Fast actions from a 'slow' receptor?. Current Opinion in Neurobiology, 26, 15-21. Abstract.

2013

Matta JA, Pelkey KA, Craig MT, Chittajallu R, Jeffries BW, McBain CJ (2013). Developmental origin dictates interneuron AMPA and NMDA receptor subunit composition and plasticity. Nat Neurosci, 16(8), 1032-1041. Abstract.  Author URL.
Craig MT, Mayne EW, Bettler B, Paulsen O, Mcbain CJ (2013). Distinct roles of GABAB1a- and GABAB1b-containing GABAB receptors in spontaneous and evoked termination of persistent cortical activity. Journal of Physiology, 591(4), 835-843. Abstract.  Full text.
Mayne EW, Craig MT, Mcbain CJ, Paulsen O (2013). Dopamine suppresses persistent network activity via D1-like dopamine receptors in rat medial entorhinal cortex. European Journal of Neuroscience, 37(8), 1242-1247. Abstract.  Full text.
Chittajallu R, Craig MT, Mcfarland A, Yuan X, Gerfen S, Tricoire L, Erkkila B, Barron SC, Lopez CM, Liang BJ, et al (2013). Dual origins of functionally distinct O-LM interneurons revealed by differential 5-HT<inf>3A</inf>R expression. Nature Neuroscience, 16(11), 1598-1607. Abstract.  Full text.
Rodríguez-Moreno A, González-Rueda A, Banerjee A, Upton AL, Craig MT, Paulsen O (2013). Presynaptic Self-Depression at Developing Neocortical Synapses. Neuron, 77(1), 35-42. Abstract.

BSc Medical Sciences:

  • Neuropharmacology CSC4009 (Lecturer) 

Back | Edit Profile